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久野 篤史 クノ アツシ

所属部署名薬理学講座
職名准教授ホームページURL
更新日 :2019/03/08

プロフィール

学位

  • 医学博士(札幌医科大学)

所属学協会

  • 国際心臓研究学会
  • 米国心臓協会
  • 日本分子生物学会
  • 日本薬理学会
  • 日本循環器学会
  • 日本内科学会
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所属学協会閉じる
  • 国際心臓研究学会
  • 米国心臓協会
  • 日本分子生物学会
  • 日本薬理学会
  • 日本循環器学会
  • 日本内科学会

研究活動

論文

  • Canagliflozin, an SGLT2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats.
    Kimura Y, Kuno A, Tanno M, Sato T, Ohno K, Shibata S, Nakata K, Sugawara H, Abe K, Igaki Y, Yano T, Miki T, Miura T
    Journal of diabetes investigation 2019年01月 [査読有り]
  • Empagliflozin, an SGLT2 inhibitor, reduced the mortality rate after acute myocardial infarction with modification of cardiac metabolomes and anti-oxidants in diabetic rats.
    Oshima H, Miki T, Kuno A, Mizuno M, Sato T, Tanno M, Yano T, Nakata K, Kimura Y, Abe K, Ohwada W, Miura T
    The Journal of pharmacology and experimental therapeutics 2018年12月 [査読有り]
  • Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice.
    Kuno A, Hosoda R, Sebori R, Hayashi T, Sakuragi H, Tanabe M, Horio Y
    Scientific Reports 8(1) 15555 2018年10月 [査読有り]
  • Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice.
    Sebori R, Kuno A, Hosoda R, Hayashi T, Horio Y
    Oxidative medicine and cellular longevity 2018 9179270 2018年10月 [査読有り]
  • Does p53 Inhibition Suppress Myocardial Ischemia-Reperfusion Injury?
    Yano T, Abe K, Tanno M, Miki T, Kuno A, Miura T, Steenbergen C
    Journal of cardiovascular pharmacology and therapeutics 23(4) 350-357 2018年07月 [査読有り]
  • Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts.
    Mizuno M, Kuno A, Yano T, Miki T, Oshima H, Sato T, Nakata K, Kimura Y, Tanno M, Miura T
    Physiological Reports 6(12) e13741 2018年06月 [査読有り]
  • Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts.
    Tatekoshi Y, Tanno M, Kouzu H, Abe K, Miki T, Kuno A, Yano T, Ishikawa S, Ohwada W, Sato T, Niinuma T, Suzuki H, Miura T
    Journal of Molecular and Cellular Cardiology 119 138-146 2018年06月 [査読有り]
  • Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats.
    Ohno K, Kuno A, Murase H, Muratsubaki S, Miki T, Tanno M, Yano T, Ishikawa S, Yamashita T, Miura T
    American journal of physiology. Heart and circulatory physiology 313(6) H1130-H1142 2017年12月 [査読有り]
  • Suppression of autophagic flux contributes to cardiomyocyte death by activation of necroptotic pathways.
    Ogasawara M, Yano T, Tanno M, Abe K, Ishikawa S, Miki T, Kuno A, Tobisawa T, Muratsubaki S, Ohno K, Tatekoshi Y, Nakata K, Ohwada W, Miura T
    Journal of molecular and cellular cardiology 108 203-213 2017年07月 [査読有り]
  • Suppressed autophagic response underlies augmentation of renal ischemia/reperfusion injury by type 2 diabetes.
    Muratsubaki S, Kuno A, Tanno M, Miki T, Yano T, Sugawara H, Shibata S, Abe K, Ishikawa S, Ohno K, Kimura Y, Tatekoshi Y, Nakata K, Ohwada W, Mizuno M, Miura T
    Scientific reports 7(1) 5311 2017年07月 [査読有り]
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  • Canagliflozin, an SGLT2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats.
    Kimura Y, Kuno A, Tanno M, Sato T, Ohno K, Shibata S, Nakata K, Sugawara H, Abe K, Igaki Y, Yano T, Miki T, Miura T
    Journal of diabetes investigation 2019年01月 [査読有り]
  • Empagliflozin, an SGLT2 inhibitor, reduced the mortality rate after acute myocardial infarction with modification of cardiac metabolomes and anti-oxidants in diabetic rats.
    Oshima H, Miki T, Kuno A, Mizuno M, Sato T, Tanno M, Yano T, Nakata K, Kimura Y, Abe K, Ohwada W, Miura T
    The Journal of pharmacology and experimental therapeutics 2018年12月 [査読有り]
  • Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice.
    Kuno A, Hosoda R, Sebori R, Hayashi T, Sakuragi H, Tanabe M, Horio Y
    Scientific Reports 8(1) 15555 2018年10月 [査読有り]
  • Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice.
    Sebori R, Kuno A, Hosoda R, Hayashi T, Horio Y
    Oxidative medicine and cellular longevity 2018 9179270 2018年10月 [査読有り]
  • Does p53 Inhibition Suppress Myocardial Ischemia-Reperfusion Injury?
    Yano T, Abe K, Tanno M, Miki T, Kuno A, Miura T, Steenbergen C
    Journal of cardiovascular pharmacology and therapeutics 23(4) 350-357 2018年07月 [査読有り]
  • Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts.
    Mizuno M, Kuno A, Yano T, Miki T, Oshima H, Sato T, Nakata K, Kimura Y, Tanno M, Miura T
    Physiological Reports 6(12) e13741 2018年06月 [査読有り]
  • Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts.
    Tatekoshi Y, Tanno M, Kouzu H, Abe K, Miki T, Kuno A, Yano T, Ishikawa S, Ohwada W, Sato T, Niinuma T, Suzuki H, Miura T
    Journal of Molecular and Cellular Cardiology 119 138-146 2018年06月 [査読有り]
  • Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats.
    Ohno K, Kuno A, Murase H, Muratsubaki S, Miki T, Tanno M, Yano T, Ishikawa S, Yamashita T, Miura T
    American journal of physiology. Heart and circulatory physiology 313(6) H1130-H1142 2017年12月 [査読有り]
  • Suppression of autophagic flux contributes to cardiomyocyte death by activation of necroptotic pathways.
    Ogasawara M, Yano T, Tanno M, Abe K, Ishikawa S, Miki T, Kuno A, Tobisawa T, Muratsubaki S, Ohno K, Tatekoshi Y, Nakata K, Ohwada W, Miura T
    Journal of molecular and cellular cardiology 108 203-213 2017年07月 [査読有り]
  • Suppressed autophagic response underlies augmentation of renal ischemia/reperfusion injury by type 2 diabetes.
    Muratsubaki S, Kuno A, Tanno M, Miki T, Yano T, Sugawara H, Shibata S, Abe K, Ishikawa S, Ohno K, Kimura Y, Tatekoshi Y, Nakata K, Ohwada W, Mizuno M, Miura T
    Scientific reports 7(1) 5311 2017年07月 [査読有り]
  • Insufficient activation of Akt upon reperfusion because of its novel modification by reduced PP2A-B55α contributes to enlargement of infarct size by chronic kidney disease.
    Tobisawa T, Yano T, Tanno M, Miki T, Kuno A, Kimura Y, Ishikawa S, Kouzu H, Nishizawa K, Yoshida H, Miura T
    Basic research in cardiology 112(3) 31 2017年05月 [査読有り]
  • Chronic Treatment With an Erythropoietin Receptor Ligand Prevents Chronic Kidney Disease-Induced Enlargement of Myocardial Infarct Size.
    Nishizawa K, Yano T, Tanno M, Miki T, Kuno A, Tobisawa T, Ogasawara M, Muratsubaki S, Ohno K, Ishikawa S, Miura T
    Hypertension (Dallas, Tex. : 1979) 68(3) 697-706 2016年09月 [査読有り]
  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
    Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RC, de la Fuente J, De Martino L, De Matteis A, De Meyer GR, De Milito A, De Santi M, de Souza W, De Tata V, De Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, Del Bello B, Del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, Der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM Jr, Doran KS, D'Orazi G, Dorn GW 2nd, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, Dunlop EA, Dunn WA Jr, Dupont N, Dupuis L, Durán RV, Durcan TM, Duvezin-Caubet S, Duvvuri U, Eapen V, Ebrahimi-Fakhari D, Echard A, Eckhart L, Edelstein CL, Edinger AL, Eichinger L, Eisenberg T, Eisenberg-Lerner A, Eissa NT, El-Deiry WS, El-Khoury V, Elazar Z, Eldar-Finkelman H, Elliott CJ, Emanuele E, Emmenegger U, Engedal N, Engelbrecht AM, Engelender S, Enserink JM, Erdmann R, Erenpreisa J, Eri R, Eriksen JL, Erman A, Escalante R, Eskelinen EL, Espert L, Esteban-Martínez L, Evans TJ, Fabri M, Fabrias G, Fabrizi C, Facchiano A, Færgeman NJ, Faggioni A, Fairlie WD, Fan C, Fan D, Fan J, Fang S, Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, Felizardo TC, Feng H, Feng Y, Feng Y, Ferguson TA, Fernández ÁF, Fernandez-Barrena MG, Fernandez-Checa JC, Fernández-López A, Fernandez-Zapico ME, Feron O, Ferraro E, Ferreira-Halder CV, Fesus L, Feuer R, Fiesel FC, Filippi-Chiela EC, Filomeni G, Fimia GM, Fingert JH, Finkbeiner S, Finkel T, Fiorito F, Fisher PB, Flajolet M, Flamigni F, Florey O, Florio S, Floto RA, Folini M, Follo C, Fon EA, Fornai F, Fortunato F, Fraldi A, Franco R, Francois A, François A, Frankel LB, Fraser ID, Frey N, Freyssenet DG, Frezza C, Friedman SL, Frigo DE, Fu D, Fuentes JM, Fueyo J, Fujitani Y, Fujiwara Y, Fujiya M, Fukuda M, Fulda S, Fusco C, Gabryel B, Gaestel M, Gailly P, Gajewska M, Galadari S, Galili G, Galindo I, Galindo MF, Galliciotti G, Galluzzi L, Galluzzi L, Galy V, Gammoh N, Gandy S, Ganesan AK, Ganesan S, Ganley IG, Gannagé M, Gao FB, Gao F, Gao JX, García Nannig L, García Véscovi E, Garcia-Macía M, Garcia-Ruiz C, Garg AD, Garg PK, Gargini R, Gassen NC, Gatica D, Gatti E, Gavard J, Gavathiotis E, Ge L, Ge P, Ge S, Gean PW, Gelmetti V, Genazzani AA, Geng J, Genschik P, Gerner L, Gestwicki JE, Gewirtz DA, Ghavami S, Ghigo E, Ghosh D, Giammarioli AM, Giampieri F, Giampietri C, Giatromanolaki A, Gibbings DJ, Gibellini L, Gibson SB, Ginet V, Giordano A, Giorgini F, Giovannetti E, Girardin SE, Gispert S, Giuliano S, Gladson CL, Glavic A, Gleave M, Godefroy N, Gogal RM Jr, Gokulan K, Goldman GH, Goletti D, Goligorsky MS, Gomes AV, Gomes LC, Gomez H, Gomez-Manzano C, Gómez-Sánchez R, Gonçalves DA, Goncu E, Gong Q, Gongora C, Gonzalez CB, Gonzalez-Alegre P, Gonzalez-Cabo P, González-Polo RA, Goping IS, Gorbea C, Gorbunov NV, Goring DR, Gorman AM, Gorski SM, Goruppi S, Goto-Yamada S, Gotor C, Gottlieb RA, Gozes I, Gozuacik D, Graba Y, Graef M, Granato GE, Grant GD, Grant S, Gravina GL, Green DR, Greenhough A, Greenwood MT, Grimaldi B, Gros F, Grose C, Groulx JF, Gruber F, Grumati P, Grune T, Guan JL, Guan KL, Guerra B, Guillen C, Gulshan K, Gunst J, Guo C, Guo L, Guo M, Guo W, Guo XG, Gust AA, Gustafsson ÅB, Gutierrez E, Gutierrez MG, Gwak HS, Haas A, Haber JE, Hadano S, Hagedorn M, Hahn DR, Halayko AJ, Hamacher-Brady A, Hamada K, Hamai A, Hamann A, Hamasaki M, Hamer I, Hamid Q, Hammond EM, Han F, Han W, Handa JT, Hanover JA, Hansen M, Harada M, Harhaji-Trajkovic L, Harper JW, Harrath AH, Harris AL, Harris J, Hasler U, Hasselblatt P, Hasui K, Hawley RG, Hawley TS, He C, He CY, He F, He G, He RR, He XH, He YW, He YY, Heath JK, Hébert MJ, Heinzen RA, Helgason GV, Hensel M, Henske EP, Her C, Herman PK, Hernández A, Hernandez C, Hernández-Tiedra S, Hetz C, Hiesinger PR, Higaki K, Hilfiker S, Hill BG, Hill JA, Hill WD, Hino K, Hofius D, Hofman P, Höglinger GU, Höhfeld J, Holz MK, Hong Y, Hood DA, Hoozemans JJ, Hoppe T, Hsu C, Hsu CY, Hsu LC, Hu D, Hu G, Hu HM, Hu H, Hu MC, Hu YC, Hu ZW, Hua F, Hua Y, Huang C, Huang HL, Huang KH, Huang KY, Huang S, Huang S, Huang WP, Huang YR, Huang Y, Huang Y, Huber TB, Huebbe P, Huh WK, Hulmi JJ, Hur GM, Hurley JH, Husak Z, Hussain SN, Hussain S, Hwang JJ, Hwang S, Hwang TI, Ichihara A, Imai Y, Imbriano C, Inomata M, Into T, Iovane V, Iovanna JL, Iozzo RV, Ip NY, Irazoqui JE, Iribarren P, Isaka Y, Isakovic AJ, Ischiropoulos H, Isenberg JS, Ishaq M, Ishida H, Ishii I, Ishmael JE, Isidoro C, Isobe K, Isono E, Issazadeh-Navikas S, Itahana K, Itakura E, Ivanov AI, Iyer AK, Izquierdo JM, Izumi Y, Izzo V, Jäättelä M, Jaber N, Jackson DJ, Jackson WT, Jacob TG, Jacques TS, Jagannath C, Jain A, Jana NR, Jang BK, Jani A, Janji B, Jannig PR, Jansson PJ, Jean S, Jendrach M, Jeon JH, Jessen N, Jeung EB, Jia K, Jia L, Jiang H, Jiang H, Jiang L, Jiang T, Jiang X, Jiang X, Jiang X, Jiang Y, Jiang Y, Jiménez A, Jin C, Jin H, Jin L, Jin M, Jin S, Jinwal UK, Jo EK, Johansen T, Johnson DE, Johnson GV, Johnson JD, Jonasch E, Jones C, Joosten LA, Jordan J, Joseph AM, Joseph B, Joubert AM, Ju D, Ju J, Juan HF, Juenemann K, Juhász G, Jung HS, Jung JU, Jung YK, Jungbluth H, Justice MJ, Jutten B, Kaakoush NO, Kaarniranta K, Kaasik A, Kabuta T, Kaeffer B, Kågedal K, Kahana A, Kajimura S, Kakhlon O, Kalia M, Kalvakolanu DV, Kamada Y, Kambas K, Kaminskyy VO, Kampinga HH, Kandouz M, Kang C, Kang R, Kang TC, Kanki T, Kanneganti TD, Kanno H, Kanthasamy AG, Kantorow M, Kaparakis-Liaskos M, Kapuy O, Karantza V, Karim MR, Karmakar P, Kaser A, Kaushik S, 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    American journal of physiology. Heart and circulatory physiology 302(12) H2536-44 2012年06月 [査読有り]
  • Role of ER stress in ventricular contractile dysfunction in type 2 diabetes.
    Takada A, Miki T, Kuno A, Kouzu H, Sunaga D, Itoh T, Tanno M, Yano T, Sato T, Ishikawa S, Miura T
    PloS one 7(6) e39893 2012年 [査読有り]
  • Cellular and molecular effects of sirtuins in health and disease.
    Horio Y, Hayashi T, Kuno A, Kunimoto R
    Clinical science (London, England : 1979) 121(5) 191-203 2011年09月 [査読有り]
  • Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy.
    Hori YS, Kuno A, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
    The Journal of pharmacology and experimental therapeutics 338(3) 784-794 2011年09月 [査読有り]
  • A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin.
    Yang X, Xin W, Yang XM, Kuno A, Rich TC, Cohen MV, Downey JM
    British journal of pharmacology 163(5) 995-1006 2011年07月 [査読有り]
  • Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection.
    Yano T, Miki T, Tanno M, Kuno A, Itoh T, Takada A, Sato T, Kouzu H, Shimamoto K, Miura T
    Hypertension (Dallas, Tex. : 1979) 57(1) 110-115 2011年01月 [査読有り]
  • Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel.
    Terashima Y, Sato T, Yano T, Maas O, Itoh T, Miki T, Tanno M, Kuno A, Shimamoto K, Miura T
    Journal of molecular and cellular cardiology 49(5) 762-770 2010年11月 [査読有り]
  • Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells.
    Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y
    FEBS letters 584(13) 2821-2826 2010年07月 [査読有り]
  • Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
    Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, Horio Y
    The Journal of biological chemistry 285(11) 8375-8382 2010年03月 [査読有り]
  • Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts.
    Hotta H, Miura T, Miki T, Togashi N, Maeda T, Kim SJ, Tanno M, Yano T, Kuno A, Itoh T, Satoh T, Terashima Y, Ishikawa S, Shimamoto K
    Circulation research 106(1) 129-132 2010年01月 [査読有り]
  • [Anti-aging drugs].
    Kuno A, Horio Y
    Nihon rinsho. Japanese journal of clinical medicine 67(7) 1384-1388 2009年07月 [査読有り]
  • Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase C.
    Kuno A, Solenkova NV, Solodushko V, Dost T, Liu Y, Yang XM, Cohen MV, Downey JM
    American journal of physiology. Heart and circulatory physiology 295(3) H1288-H1295 2008年09月 [査読有り]
  • The delta-opioid receptor agonist DADLE at reperfusion protects the heart through activation of pro-survival kinases via EGF receptor transactivation.
    Förster K, Kuno A, Solenkova N, Felix SB, Krieg T
    American journal of physiology. Heart and circulatory physiology 293(3) H1604-8 2007年09月 [査読有り]
  • Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion.
    Kuno A, Critz SD, Cui L, Solodushko V, Yang XM, Krahn T, Albrecht B, Philipp S, Cohen MV, Downey JM
    Journal of molecular and cellular cardiology 43(3) 262-271 2007年09月 [査読有り]
  • Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways.
    Cohen MV, Philipp S, Krieg T, Cui L, Kuno A, Solodushko V, Downey JM
    Journal of molecular and cellular cardiology 42(4) 842-851 2007年04月 [査読有り]
  • Total liquid ventilation provides ultra-fast cardioprotective cooling.
    Tissier R, Hamanaka K, Kuno A, Parker JC, Cohen MV, Downey JM
    Journal of the American College of Cardiology 49(5) 601-605 2007年02月 [査読有り]
  • Nicorandil opens mitochondrial K(ATP) channels not only directly but also through a NO-PKG-dependent pathway.
    Kuno A, Critz SD, Cohen MV, Downey JM
    Basic research in cardiology 102(1) 73-79 2007年01月 [査読有り]
  • Protective role of gap junctions in preconditioning against myocardial infarction.
    Miura T, Ohnuma Y, Kuno A, Tanno M, Ichikawa Y, Nakamura Y, Yano T, Miki T, Sakamoto J, Shimamoto K
    American journal of physiology. Heart and circulatory physiology 286(1) H214-21 2004年01月 [査読有り]
  • Interruption of signal transduction between G protein and PKC-epsilon underlies the impaired myocardial response to ischemic preconditioning in postinfarct remodeled hearts.
    Miki T, Miura T, Tanno M, Sakamoto J, Kuno A, Genda S, Matsumoto T, Ichikawa Y, Shimamoto K
    Molecular and cellular biochemistry 247(1-2) 185-193 2003年05月 [査読有り]
  • Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C.
    Tsuchida A, Miura T, Tanno M, Sakamoto J, Miki T, Kuno A, Matsumoto T, Ohnuma Y, Ichikawa Y, Shimamoto K
    Journal of the American College of Cardiology 40(8) 1523-1530 2002年10月 [査読有り]
  • Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning.
    Ohnuma Y, Miura T, Miki T, Tanno M, Kuno A, Tsuchida A, Shimamoto K
    American journal of physiology. Heart and circulatory physiology 283(1) H440-7 2002年07月 [査読有り]
  • Blockade of angiotensin II type 1 receptors suppressed free radical production and preserved coronary endothelial function in the rabbit heart after myocardial infarction.
    Kuno A, Miura T, Tsuchida A, Hasegawa T, Miki T, Nishino Y, Shimamoto K
    Journal of cardiovascular pharmacology 39(1) 49-57 2002年01月 [査読有り]
  • Endothelium-dependent coronary response is impaired in the myocardium at an early phase of post-infarct remodeling.
    Hasegawa T, Miura T, Tsuchida A, Miki T, Nakano A, Kuno A, Shimamoto K.
    Jpn Heart J 41(6) 743-755 2000年 [査読有り]
  • Mobile intracardiac calcinosis: a new risk of thromboembolism in patients with haemodialysed end stage renal disease.
    Tsuchihashi K, Nozawa A, Marusaki S, Moniwa N, Oh-numa Y, Kuno A, Takagi S, Takizawa H, Ura N, Shimamoto K.
    Heart 82(5) 638-640 1999年 [査読有り]
  • Sustained right ventricular dyskinesis complicated by right ventricular infarction.
    Nakata T, Hashimoto A, Kuno A,Tsuchihashi K, Yonekura S, Shimamoto K
    J Nucl Med. 38(9) 1421-1423 1997年 [査読有り]
  • Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction.
    Tsuchida A, Miura T, Miki T, Kuno A, Tanno M, Nozawa Y, Genda S, Matsumoto T, Shimamoto K.
    Basic Res Cardiol. 96(5) 446-453 [査読有り]

MISC

  • レスベラトロールによる筋ジストロフィーの治療
    堀尾 嘉幸, 久野 篤史, 川村 健太郎, 堤 裕幸
    BIO Clinica 33(8) 770-775 2018年07月
  • SIRT1は老化関連タンパクPrl2C3を負に制御する(SIRT1 negatively regulates the expression of Prl2C3, a senescence-associated protein)
    堀本 浩平, 國本 梨沙, 橋本 梨沙, 上田 直弘, 細田 隆介, 久野 篤史, 山下 利春, 堀尾 嘉幸
    札幌医学雑誌 86(1-6) 63-71 2017年12月
  • 長寿遺伝子SIRT1活性化による筋ジストロフィーの治療
    久野 篤史, 川村 健太郎, 堀尾 嘉幸
    臨床薬理の進歩(38) 79-86 2017年06月
  • 筋ジストロフィーの新治療法の開発
    久野 篤史, 細田 隆介, 堀尾 嘉幸
    Medical Science Digest 42(13) 642-646 2016年12月
  • 【超高齢化時代の呼吸器診療】 基礎医学とのダイアローグ 長寿遺伝子サーチュイン
    堀尾 嘉幸, 久野 篤史, 國本 梨沙
    THE LUNG-perspectives 24(3) 303-306 2016年08月
  • 酸化ストレスによるミトコンドリア透過性遷移に対するニコランジルの効果
    須永 大介, 石川 聡子, 神津 英至, 久野 篤史, 丹野 雅也, 三木 隆幸, 三浦 哲嗣
    Therapeutic Research 34(3) 296,304-299,304 2013年03月
  • 【レスベラトロール】 レスベラトロールの筋肉・神経疾患への応用
    堀尾 嘉幸, 久野 篤史
    アンチ・エイジング医学 8(6) 906-912 2012年12月
  • 【がん疼痛の管理 アセトアミノフェンとNSAIDs】 アセトアミノフェンとNSAIDsが及ぼす副作用リスクとその対応 NSAIDsと心・脳血管障害
    久野 篤史, 三浦 哲嗣
    薬局 63(6) 2321-2326 2012年05月
  • 糖尿病心筋の心保護機構破綻の分子メカニズムにおけるSIRT1の意義
    久野 篤史
    医科学応用研究財団研究報告 31 269-271 2012年
  • 心臓老化Cardiac agingの研究 : 長寿遺伝子Sirtuinの心臓における働きと老化
    久野 篤史
    福田記念医療技術振興財団情報(24) 55-57 2011年12月
MISCを全て表示する
  • レスベラトロールによる筋ジストロフィーの治療
    堀尾 嘉幸, 久野 篤史, 川村 健太郎, 堤 裕幸
    BIO Clinica 33(8) 770-775 2018年07月
  • SIRT1は老化関連タンパクPrl2C3を負に制御する(SIRT1 negatively regulates the expression of Prl2C3, a senescence-associated protein)
    堀本 浩平, 國本 梨沙, 橋本 梨沙, 上田 直弘, 細田 隆介, 久野 篤史, 山下 利春, 堀尾 嘉幸
    札幌医学雑誌 86(1-6) 63-71 2017年12月
  • 長寿遺伝子SIRT1活性化による筋ジストロフィーの治療
    久野 篤史, 川村 健太郎, 堀尾 嘉幸
    臨床薬理の進歩(38) 79-86 2017年06月
  • 筋ジストロフィーの新治療法の開発
    久野 篤史, 細田 隆介, 堀尾 嘉幸
    Medical Science Digest 42(13) 642-646 2016年12月
  • 【超高齢化時代の呼吸器診療】 基礎医学とのダイアローグ 長寿遺伝子サーチュイン
    堀尾 嘉幸, 久野 篤史, 國本 梨沙
    THE LUNG-perspectives 24(3) 303-306 2016年08月
  • 酸化ストレスによるミトコンドリア透過性遷移に対するニコランジルの効果
    須永 大介, 石川 聡子, 神津 英至, 久野 篤史, 丹野 雅也, 三木 隆幸, 三浦 哲嗣
    Therapeutic Research 34(3) 296,304-299,304 2013年03月
  • 【レスベラトロール】 レスベラトロールの筋肉・神経疾患への応用
    堀尾 嘉幸, 久野 篤史
    アンチ・エイジング医学 8(6) 906-912 2012年12月
  • 【がん疼痛の管理 アセトアミノフェンとNSAIDs】 アセトアミノフェンとNSAIDsが及ぼす副作用リスクとその対応 NSAIDsと心・脳血管障害
    久野 篤史, 三浦 哲嗣
    薬局 63(6) 2321-2326 2012年05月
  • 糖尿病心筋の心保護機構破綻の分子メカニズムにおけるSIRT1の意義
    久野 篤史
    医科学応用研究財団研究報告 31 269-271 2012年
  • 心臓老化Cardiac agingの研究 : 長寿遺伝子Sirtuinの心臓における働きと老化
    久野 篤史
    福田記念医療技術振興財団情報(24) 55-57 2011年12月
  • 【アンチエイジング医学 基礎・臨床研究の進歩】 臨床研究の進歩 老化抑制と健康寿命延長の方法論 薬剤によるアンチエイジング 老化抑制薬
    久野 篤史, 堀尾 嘉幸
    日本臨床 67(7) 1384-1388 2009年07月
  • 膝窩動脈アプローチにより経皮的下肢動脈形成術が可能となった大腿動脈閉塞性動脈硬化症の1例
    百石 雅哉, 久野 篤史, 中野 淳, 長谷川 亨
    道南医学会誌(40) 128-131 2005年03月
  • 甲状腺機能亢進症を伴う冠動脈攣縮性狭心症の1例
    加藤 伸郎, 久野 篤史, 百石 雅哉, 中野 淳, 長谷川 亨
    道南医学会誌(40) 131-133 2005年03月
  • 心不全を契機に初めて診断された成人発症型ネマリンミオパチーの1症例
    中野 淳, 吉岡 拓司, 百石 雅哉, 久野 篤史, 長谷川 亨, 佐藤 達郎
    心臓 37(2) 150-154 2005年02月
  • DDDペースメーカー植え込みを施行したHOCM患者の8年の経過
    吉岡 拓司, 中村 裕一, 久野 篤史, 中野 淳, 長谷川 亨
    道南医学会誌(39) 170-172 2004年04月
  • 左室流出路狭窄を呈したたこつぼ型心筋症の1例
    西里 仁男, 久野 篤史, 中野 淳, 長谷川 亨
    道南医学会誌(38) 89-91 2003年07月
  • 閉塞性肥大型心筋症に対する経皮的中隔心筋焼灼術 術後8ヵ月の効果
    久野 篤史, 西里 仁男, 中野 淳, 長谷川 亨, 榊原 亨
    道南医学会誌(38) 110-112 2003年07月
  • Bail-out stentに成功した対角枝早期複雑再狭窄病変の1例
    長尾 和彦, 老松 寛, 久野 篤史
    道南医学会誌(32) 43-44 1997年07月
  • 当院での急性冠症候群(Acute Coronary Syndrome)における冠動脈ステント植え込みの成績
    遠藤 明太, 老松 寛, 久野 篤史
    道南医学会誌(32) 58-60 1997年07月
  • 当院にて最近経験したシングルパスリードVDDペースメーカー植え込みの7例
    土井 敦, 老松 寛, 久野 篤史
    道南医学会誌(32) 38-40 1997年07月
  • 人工血管再狭窄病変に対しStent植え込みが有用であった閉塞性動脈硬化症の1例
    久野 篤史, 老松 寛, 土井 敦
    道南医学会誌(32) 41-42 1997年07月
  • Parallel wire techniqueにて静脈グラフト屈曲病変へのステント植え込みに成功した不安定狭心症の一例
    遠藤 明太, 老松 寛, 久野 篤史
    函館五稜郭病院医誌 5 91-96 1997年05月

講演・口頭発表

  • レスベラトロールによる筋ジストロフィー治療
    久野 篤史
    第69回 日本薬理学会北部 2018年09月21日
  • The SIRT1 activator resveratrol ameliorates dystrophic cardiomyopathy by promoting mitophagy.
    久野 篤史
    European Society of Cardiology Congress 2018 2018年08月28日
  • Restoration of impaired autophagosome clearance underlies amelioration of cardiomyopathy afforded by SIRT1 activation in dystrophin-deficient mice.
    久野 篤史
    第34回 国際心臓研究学会日本部会(ISHR2017) 2017年12月08日
  • 筋ジストロフィー心筋におけるオートファジー不全の意義
    久野 篤史
    第68回 日本薬理学会北部会 2017年09月15日
  • Role of impaired autophagy caused by aberrant activation of mTORC1 in dystrophic cardiomyopathy.
    久野 篤史
    Keystone Symposia Conference: Aging and Mechanisms of Aging-Related Disease 2017年05月15日
  • Resveratrolrestores autophagy and improves cardiac dysfunction in a mouse model of Duchenne muscular dystrophy.
    久野 篤史
    第90回 日本薬理学会年会 2017年03月15日
  • Protective roles of SIRT1 in the cardiomyocyte in doxorubicin-induce cardiotoxicity.
    久野 篤史
    第33回 国際心臓研究学会日本部会 (ISHR2016) 2016年12月17日
  • 筋ジストロフィーの心筋障害におけるオートファジー不全の意義
    久野 篤史
    第39回 日本分子生物学会 2016年11月30日
  • Impaired Autophagy Induced by Activated mTORC1 Underlies Development of Dystrophic Cardiomyopathy.
    久野 篤史
    American Heart Association Scientific Sessions 2016 2016年11月12日
  • 筋ジストロフィー心筋障害におけるオートファジー不全の意義とレスベラトロールによる治療効果
    久野 篤史
    第67回 日本薬理学会北部会 2016年09月30日
講演・口頭発表等を全て表示する
講演・口頭発表等閉じる
  • レスベラトロールによる筋ジストロフィー治療
    久野 篤史
    第69回 日本薬理学会北部 2018年09月21日
  • The SIRT1 activator resveratrol ameliorates dystrophic cardiomyopathy by promoting mitophagy.
    久野 篤史
    European Society of Cardiology Congress 2018 2018年08月28日
  • Restoration of impaired autophagosome clearance underlies amelioration of cardiomyopathy afforded by SIRT1 activation in dystrophin-deficient mice.
    久野 篤史
    第34回 国際心臓研究学会日本部会(ISHR2017) 2017年12月08日
  • 筋ジストロフィー心筋におけるオートファジー不全の意義
    久野 篤史
    第68回 日本薬理学会北部会 2017年09月15日
  • Role of impaired autophagy caused by aberrant activation of mTORC1 in dystrophic cardiomyopathy.
    久野 篤史
    Keystone Symposia Conference: Aging and Mechanisms of Aging-Related Disease 2017年05月15日
  • Resveratrolrestores autophagy and improves cardiac dysfunction in a mouse model of Duchenne muscular dystrophy.
    久野 篤史
    第90回 日本薬理学会年会 2017年03月15日
  • Protective roles of SIRT1 in the cardiomyocyte in doxorubicin-induce cardiotoxicity.
    久野 篤史
    第33回 国際心臓研究学会日本部会 (ISHR2016) 2016年12月17日
  • 筋ジストロフィーの心筋障害におけるオートファジー不全の意義
    久野 篤史
    第39回 日本分子生物学会 2016年11月30日
  • Impaired Autophagy Induced by Activated mTORC1 Underlies Development of Dystrophic Cardiomyopathy.
    久野 篤史
    American Heart Association Scientific Sessions 2016 2016年11月12日
  • 筋ジストロフィー心筋障害におけるオートファジー不全の意義とレスベラトロールによる治療効果
    久野 篤史
    第67回 日本薬理学会北部会 2016年09月30日
  • Deletion of SIRT1 in the cardiomyocyte worsens doxorubicin-induced cardiac dysfunction in mice.
    久野 篤史
    European Society of Cardiology Congress 2016 2016年08月27日
  • SIRT1 Protects against Doxorubicin Cardiotoxicity In Vivo.
    久野 篤史
    第80回 日本循環器学会 2016年03月18日

特許

  • 筋ジストロフィーを処置するための組成物
    堀尾 嘉幸, 久野 篤史, 堀 佑輔
    特願2012-5340172011年09月13日
  • 筋ジストロフィーを処置するための組成物
    堀尾 嘉幸, 久野 篤史, 堀 佑輔
    JP20110708942011年09月13日


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