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三浦 哲嗣 ミウラ テツジ

所属部署名循環器・腎臓・代謝内分泌内科学講座
職名教授ホームページURL
更新日 :2017/09/13

プロフィール

研究キーワード

    Cardiology, Cardiovascular Physiology, Signal Transduction, Preconditioning, Mitochondria, 循環器内科学 循環生理学

研究分野

  • 内科系臨床医学 / 循環器内科学

学位

  • 博士(医学)

学歴

  • -
    1980年
    札幌医科大学(日本)

所属学協会

  • 日本糖尿病学会
  • 日本腎臓学会
  • 日本循環制御医学会(理事)
  • 米国心臓協会 (Fellow)
  • 日本循環器学会(社員)
  • 米国心臓病学会 (Fellow)
  • ヨーロッパ心臓病学会 (Fellow)
  • 日本心不全学会(評議員)
  • 日本心電学会
  • 米国生理学会
所属学協会を全て表示する
所属学協会閉じる
  • 日本糖尿病学会
  • 日本腎臓学会
  • 日本循環制御医学会(理事)
  • 米国心臓協会 (Fellow)
  • 日本循環器学会(社員)
  • 米国心臓病学会 (Fellow)
  • ヨーロッパ心臓病学会 (Fellow)
  • 日本心不全学会(評議員)
  • 日本心電学会
  • 米国生理学会
  • 日本内科学会(評議員)
  • 心血管病理学会
  • 国際心臓研究学会日本部会(理事)

研究活動

論文

  • Angiotensin II receptor blockers decrease serum concentration of fatty acid-binding protein 4 in patients with hypertension.
    Furuhashi M, Mita T, Moniwa N, Hoshina K, Ishimura S, Fuseya T, Watanabe Y, Yoshida H, Shimamoto K, Miura T
    Hypertension research : official journal of the Japanese Society of Hypertension 38 252-259 2015年04月 [査読有り]
  • The combination of abdominal obesity and high-sensitivity C-reactive protein predicts new-onset hypertension in the general Japanese population: the Tanno-Sobetsu study.
    Fujii M, Ohnishi H, Saitoh S, Akasaka H, Miura T, Mori M
    Hypertension research : official journal of the Japanese Society of Hypertension 2015年03月 [査読有り]
  • Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart.
    Kouzu H, Miki T, Tanno M, Kuno A, Yano T, Itoh T, Sato T, Sunaga D, Murase H, Tobisawa T, Ogasawara M, Ishikawa S, Miura T
    Journal of molecular and cellular cardiology 80 136-145 2015年03月 [査読有り]
  • FABP4 is secreted from adipocytes by adenyl cyclase-PKA- and guanylyl cyclase-PKG-dependent lipolytic mechanisms.
    Mita T, Furuhashi M, Hiramitsu S, Ishii J, Hoshina K, Ishimura S, Fuseya T, Watanabe Y, Tanaka M, Ohno K, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Shimamoto K, Miura T
    Obesity (Silver Spring, Md.) 23 359-367 2015年02月 [査読有り]
  • Everolimus-responsive dilated cardiomyopathy in tuberous sclerosis.
    Koyama M, Yano T, Kikuchi K, Miura T
    European heart journal 2015年01月 [査読有り]
  • Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker.
    Furuhashi M, Moniwa N, Mita T, Fuseya T, Ishimura S, Ohno K, Shibata S, Tanaka M, Watanabe Y, Akasaka H, Ohnishi H, Yoshida H, Takizawa H, Saitoh S, Ura N, Shimamoto K, Miura T
    American journal of hypertension 28 15-21 2015年01月 [査読有り]
  • Reduction of endoplasmic reticulum stress inhibits neointima formation after vascular injury.
    Ishimura S, Furuhashi M, Mita T, Fuseya T, Watanabe Y, Hoshina K, Kokubu N, Inoue K, Yoshida H, Miura T
    Scientific reports 4 6943 2014年11月 [査読有り]
  • Translocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2).
    Tanno M, Kuno A, Ishikawa S, Miki T, Kouzu H, Yano T, Murase H, Tobisawa T, Ogasawara M, Horio Y, Miura T
    The Journal of biological chemistry 289 29285-29296 2014年10月 [査読有り]
  • The impact of elevation of serum uric acid level on the natural history of glomerular filtration rate (GFR) and its sex difference.
    Akasaka H, Yoshida H, Takizawa H, Hanawa N, Tobisawa T, Tanaka M, Moniwa N, Togashi N, Yamashita T, Kuroda S, Ura N, Miura T, BOREAS-CKD1 Investigators
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 29 1932-1939 2014年10月 [査読有り]
  • Disease-associated polymorphisms in 9p21 are not associated with extreme longevity.
    Congrains A, Kamide K, Hirose N, Arai Y, Oguro R, Nakama C, Imaizumi Y, Kawai T, Kusunoki H, Yamamoto H, Onishi-Takeya M, Takeya Y, Yamamoto K, Sugimoto K, Akasaka H, Saitoh S, Miura T, Awata N, Kato N, Katsuya T, Ikebe K, Gondo Y, Rakugi H
    Geriatrics & gerontology international 2014年09月 [査読有り]
論文を全て表示する
論文閉じる
  • Angiotensin II receptor blockers decrease serum concentration of fatty acid-binding protein 4 in patients with hypertension.
    Furuhashi M, Mita T, Moniwa N, Hoshina K, Ishimura S, Fuseya T, Watanabe Y, Yoshida H, Shimamoto K, Miura T
    Hypertension research : official journal of the Japanese Society of Hypertension 38 252-259 2015年04月 [査読有り]
  • The combination of abdominal obesity and high-sensitivity C-reactive protein predicts new-onset hypertension in the general Japanese population: the Tanno-Sobetsu study.
    Fujii M, Ohnishi H, Saitoh S, Akasaka H, Miura T, Mori M
    Hypertension research : official journal of the Japanese Society of Hypertension 2015年03月 [査読有り]
  • Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart.
    Kouzu H, Miki T, Tanno M, Kuno A, Yano T, Itoh T, Sato T, Sunaga D, Murase H, Tobisawa T, Ogasawara M, Ishikawa S, Miura T
    Journal of molecular and cellular cardiology 80 136-145 2015年03月 [査読有り]
  • FABP4 is secreted from adipocytes by adenyl cyclase-PKA- and guanylyl cyclase-PKG-dependent lipolytic mechanisms.
    Mita T, Furuhashi M, Hiramitsu S, Ishii J, Hoshina K, Ishimura S, Fuseya T, Watanabe Y, Tanaka M, Ohno K, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Shimamoto K, Miura T
    Obesity (Silver Spring, Md.) 23 359-367 2015年02月 [査読有り]
  • Everolimus-responsive dilated cardiomyopathy in tuberous sclerosis.
    Koyama M, Yano T, Kikuchi K, Miura T
    European heart journal 2015年01月 [査読有り]
  • Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker.
    Furuhashi M, Moniwa N, Mita T, Fuseya T, Ishimura S, Ohno K, Shibata S, Tanaka M, Watanabe Y, Akasaka H, Ohnishi H, Yoshida H, Takizawa H, Saitoh S, Ura N, Shimamoto K, Miura T
    American journal of hypertension 28 15-21 2015年01月 [査読有り]
  • Reduction of endoplasmic reticulum stress inhibits neointima formation after vascular injury.
    Ishimura S, Furuhashi M, Mita T, Fuseya T, Watanabe Y, Hoshina K, Kokubu N, Inoue K, Yoshida H, Miura T
    Scientific reports 4 6943 2014年11月 [査読有り]
  • Translocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2).
    Tanno M, Kuno A, Ishikawa S, Miki T, Kouzu H, Yano T, Murase H, Tobisawa T, Ogasawara M, Horio Y, Miura T
    The Journal of biological chemistry 289 29285-29296 2014年10月 [査読有り]
  • The impact of elevation of serum uric acid level on the natural history of glomerular filtration rate (GFR) and its sex difference.
    Akasaka H, Yoshida H, Takizawa H, Hanawa N, Tobisawa T, Tanaka M, Moniwa N, Togashi N, Yamashita T, Kuroda S, Ura N, Miura T, BOREAS-CKD1 Investigators
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 29 1932-1939 2014年10月 [査読有り]
  • Disease-associated polymorphisms in 9p21 are not associated with extreme longevity.
    Congrains A, Kamide K, Hirose N, Arai Y, Oguro R, Nakama C, Imaizumi Y, Kawai T, Kusunoki H, Yamamoto H, Onishi-Takeya M, Takeya Y, Yamamoto K, Sugimoto K, Akasaka H, Saitoh S, Miura T, Awata N, Kato N, Katsuya T, Ikebe K, Gondo Y, Rakugi H
    Geriatrics & gerontology international 2014年09月 [査読有り]
  • Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population.
    Fuseya T, Furuhashi M, Yuda S, Muranaka A, Kawamukai M, Mita T, Ishimura S, Watanabe Y, Hoshina K, Tanaka M, Ohno K, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Shimamoto K, Miura T
    Cardiovascular diabetology 13 126 2014年08月 [査読有り]
  • Does glycemic control reverse dispersion of ventricular repolarization in type 2 diabetes?
    Miki T, Tobisawa T, Sato T, Tanno M, Yano T, Akasaka H, Kuno A, Ogasawara M, Murase H, Saitoh S, Miura T
    Cardiovascular diabetology 13 125 2014年08月 [査読有り]
  • Cardiac tamponade leading to the diagnosis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a case report and review of the literature.
    Yano T, Ishimura S, Furukawa T, Koyama M, Tanaka M, Shimoshige S, Hashimoto A, Miura T
    Heart and vessels 2014年07月 [査読有り]
  • "Ballooning" patterns in takotsubo cardiomyopathy reflect different clinical backgrounds and outcomes: a BOREAS-TCM study.
    Nishida J, Kouzu H, Hashimoto A, Fujito T, Kawamukai M, Mochizuki A, Muranaka A, Kokubu N, Shimoshige S, Yuda S, Hase M, Tsuchihashi K, Miura T
    Heart and vessels 2014年07月 [査読有り]
  • Inter-vendor variability of left ventricular volumes and strains determined by three-dimensional speckle tracking echocardiography.
    Yuda S, Sato Y, Abe K, Kawamukai M, Kouzu H, Muranaka A, Kokubu N, Hashimoto A, Tsuchihashi K, Watanabe N, Miura T
    Echocardiography (Mount Kisco, N.Y.) 31 597-604 2014年05月 [査読有り]
  • Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension.
    Koyama M, Furuhashi M, Ishimura S, Mita T, Fuseya T, Okazaki Y, Yoshida H, Tsuchihashi K, Miura T
    American journal of physiology. Heart and circulatory physiology 306 H1314-23 2014年05月 [査読有り]
  • Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling.
    Yano T, Ferlito M, Aponte A, Kuno A, Miura T, Murphy E, Steenbergen C
    Circulation research 114 1268-1280 2014年04月 [査読有り]
  • Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2.
    Sato T, Kobayashi T, Kuno A, Miki T, Tanno M, Kouzu H, Itoh T, Ishikawa S, Kojima T, Miura T, Tohse N
    American journal of physiology. Heart and circulatory physiology 306 H1054-65 2014年04月 [査読有り]
  • HASF, a PKC-ε activator with novel features for cardiomyocyte protection.
    Miura T
    Journal of molecular and cellular cardiology 69 1-3 2014年04月 [査読有り]
  • Comparative effects of telmisartan and valsartan as add-on agents for hypertensive patients with morning blood pressure insufficiently controlled by amlodipine monotherapy.
    Yoshida H, Akasaka H, Saitoh S, Shimamoto K, Miura T, SPEED investigators
    Hypertension research : official journal of the Japanese Society of Hypertension 37 225-231 2014年03月 [査読有り]
  • Atrial electromechanical interval may predict cardioembolic stroke in apparently low risk elderly patients with paroxysmal atrial fibrillation.
    Hoshi Y, Nozawa Y, Ogasawara M, Yuda S, Sato S, Sakasai T, Oka M, Katayama H, Sato M, Kouzu H, Nishihara M, Doi A, Nishimiya T, Miura T
    Echocardiography (Mount Kisco, N.Y.) 31 140-148 2014年02月 [査読有り]
  • Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases.
    Furuhashi M, Saitoh S, Shimamoto K, Miura T
    Clinical Medicine Insights. Cardiology 8 23-33 2014年 [査読有り]
  • Ectopic expression of fatty acid-binding protein 4 in the glomerulus is associated with proteinuria and renal dysfunction.
    Tanaka M, Furuhashi M, Okazaki Y, Mita T, Fuseya T, Ohno K, Ishimura S, Yoshida H, Miura T
    Nephron. Clinical practice 128 345-351 2014年 [査読有り]
  • Urinary excretion of fatty acid-binding protein 4 is associated with albuminuria and renal dysfunction.
    Okazaki Y, Furuhashi M, Tanaka M, Mita T, Fuseya T, Ishimura S, Watanabe Y, Hoshina K, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Shimamoto K, Miura T
    PloS one 9 e115429 2014年 [査読有り]
  • Accelerated recovery of mitochondrial membrane potential by GSK-3β inactivation affords cardiomyocytes protection from oxidant-induced necrosis.
    Sunaga D, Tanno M, Kuno A, Ishikawa S, Ogasawara M, Yano T, Miki T, Miura T
    PloS one 9 e112529 2014年 [査読有り]
  • Relation of serum adiponectin levels and obesity with breast cancer: a Japanese case-control study.
    Minatoya M, Kutomi G, Shima H, Asakura S, Otokozawa S, Ohnishi H, Akasaka H, Miura T, Mori M, Hirata K
    Asian Pacific journal of cancer prevention : APJCP 15 8325-8330 2014年 [査読有り]
  • Counts of Slackia sp. strain NATTS in intestinal flora are correlated to serum concentrations of equol both in prostate cancer cases and controls in Japanese men.
    Sugiyama Y, Nagata Y, Fukuta F, Takayanagi A, Masumori N, Tsukamoto T, Akasaka H, Ohnishi H, Saito S, Miura T, Moriyama K, Tsuji H, Akaza H, Mori M
    Asian Pacific journal of cancer prevention : APJCP 15 2693-2697 2014年 [査読有り]
  • Inflammatory myofibroblastic tumor of the heart. Overlap with IgG4-related disease?
    Kouzu H, Miki T, Mizuno M, Kimura Y, Muranaka A, Yuda S, Keira Y, Hasegawa T, Miyaki Y, Takagi N, Higami T, Miura T
    Circulation journal : official journal of the Japanese Circulation Society 78 1006-1008 2014年 [査読有り]
  • Relationship of serum isoflavone, insulin and adiponectin levels with breast cancer risk.
    Minatoya M, Kutomi G, Asakura S, Otokozawa S, Sugiyama Y, Ohnishi H, Akasaka H, Miura T, Mori M, Hirata K
    Breast cancer (Tokyo, Japan) 2013年10月 [査読有り]
  • Delayed ventricular septal perforation caused by minimal branches occlusion during coronary artery stenting.
    Fujii N, Tsuchihashi K, Nishida J, Funayama N, Takagi S, Miura T
    Cardiovascular intervention and therapeutics 28 383-387 2013年10月 [査読有り]
  • Diabetic cardiomyopathy: pathophysiology and clinical features.
    Miki T, Yuda S, Kouzu H, Miura T
    Heart failure reviews 18 149-166 2013年03月 [査読有り]
  • Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein.
    Kuno A, Hori YS, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
    The Journal of biological chemistry 288 5963-5972 2013年02月 [査読有り]
  • Assessment of left atrial deformation and synchrony by three-dimensional speckle-tracking echocardiography: comparative studies in healthy subjects and patients with atrial fibrillation.
    Mochizuki A, Yuda S, Oi Y, Kawamukai M, Nishida J, Kouzu H, Muranaka A, Kokubu N, Shimoshige S, Hashimoto A, Tsuchihashi K, Watanabe N, Miura T
    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 26 165-174 2013年02月 [査読有り]
  • Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population.
    Ishimura S, Furuhashi M, Watanabe Y, Hoshina K, Fuseya T, Mita T, Okazaki Y, Koyama M, Tanaka M, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Miura T
    PloS one 8 e81318 2013年 [査読有り]
  • Glucagon-like peptide-1 secretory function as an independent determinant of blood pressure: analysis in the Tanno-Sobetsu study.
    Yoshihara M, Akasaka H, Ohnishi H, Miki T, Furukawa T, Yuda S, Saitoh S, Miura T
    PloS one 8 e67578 2013年 [査読有り]
  • Histopathology of the pancreas in fulminant type 1 diabetes after 23-year follow-up: a case report.
    Sato T, Miki T, Murakami N, Hirohashi Y, Kouzu H, Furuhashi M, Tanno M, Yuda S, Saitoh S, Hasegawa T, Miura T
    Pathology international 62 827-829 2012年12月 [査読有り]
  • Cytoprotective regulation of the mitochondrial permeability transition pore is impaired in type 2 diabetic Goto-Kakizaki rat hearts.
    Itoh T, Kouzu H, Miki T, Tanno M, Kuno A, Sato T, Sunaga D, Murase H, Miura T
    Journal of molecular and cellular cardiology 53 870-879 2012年12月 [査読有り]
  • Trials, tribulations and speculation! Report from the 7th Biennial Hatter Cardiovascular Institute Workshop.
    Bell R, Beeuwkes R, Bøtker HE, Davidson S, Downey J, Garcia-Dorado D, Hausenloy DJ, Heusch G, Ibanez B, Kitakaze M, Lecour S, Mentzer R, Miura T, Opie L, Ovize M, Ruiz-Meana M, Schulz R, Shannon R, Walker M, Vinten-Johansen J, Yellon D
    Basic research in cardiology 107 300 2012年11月 [査読有り]
  • Effects of parental hypertension on longitudinal trends in blood pressure and plasma metabolic profile: mixed-effects model analysis.
    Mitsumata K, Saitoh S, Ohnishi H, Akasaka H, Miura T
    Hypertension 60 1124-1130 2012年11月 [査読有り]
  • Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation.
    Ota H, Furuhashi M, Ishimura S, Koyama M, Okazaki Y, Mita T, Fuseya T, Yamashita T, Tanaka M, Yoshida H, Shimamoto K, Miura T
    American journal of hypertension 25 1124-1130 2012年10月 [査読有り]
  • Delayed visceral bleeding from liver injury after cardiopulmonary resuscitation.
    Kouzu H, Hase M, Kokubu N, Nishida J, Kawamukai M, Usami Y, Hirokawa N, Meguro M, Tsuchihashi K, Miura T, Asai Y, Shimamoto K
    The Journal of emergency medicine 43 e245-8 2012年10月 [査読有り]
  • Emerging beneficial roles of sirtuins in heart failure.
    Tanno M, Kuno A, Horio Y, Miura T
    Basic research in cardiology 107 273 2012年07月 [査読有り]
  • Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning.
    Miki T, Itoh T, Sunaga D, Miura T
    Cardiovascular diabetology 11 67 2012年06月 [査読有り]
  • Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes.
    Ishikawa S, Kuno A, Tanno M, Miki T, Kouzu H, Itoh T, Sato T, Sunaga D, Murase H, Miura T
    American journal of physiology. Heart and circulatory physiology 302 H2536-44 2012年06月 [査読有り]
  • Cardiac mortality assessment improved by evaluation of cardiac sympathetic nerve activity in combination with hemoglobin and kidney function in chronic heart failure patients.
    Doi T, Nakata T, Hashimoto A, Yuda S, Wakabayashi T, Kouzu H, Kaneko N, Hase M, Tsuchihashi K, Miura T
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine 53 731-740 2012年05月 [査読有り]
  • The mPTP and its regulatory proteins: final common targets of signalling pathways for protection against necrosis.
    Miura T, Tanno M
    Cardiovascular research 94 181-189 2012年05月 [査読有り]
  • Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy.
    Yamashita T, Fujimiya M, Nagaishi K, Ataka K, Tanaka M, Yoshida H, Tsuchihashi K, Shimamoto K, Miura T
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26 1559-1568 2012年04月 [査読有り]
  • Angiotensin II receptor activation in youth triggers persistent insulin resistance and hypertension--a legacy effect?
    Togashi N, Maeda T, Yoshida H, Koyama M, Tanaka M, Furuhashi M, Shimamoto K, Miura T
    Hypertension research : official journal of the Japanese Society of Hypertension 35 334-340 2012年03月 [査読有り]
  • A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration.
    Oguro R, Kamide K, Katsuya T, Akasaka H, Sugimoto K, Congrains A, Arai Y, Hirose N, Saitoh S, Ohishi M, Miura T, Rakugi H
    Experimental gerontology 47 183-187 2012年02月 [査読有り]
  • Synergistic prognostic values of cardiac sympathetic innervation with left ventricular hypertrophy and left atrial size in heart failure patients without reduced left ventricular ejection fraction: a cohort study.
    Doi T, Nakata T, Hashimoto A, Yuda S, Wakabayashi T, Kouzu H, Kaneko N, Hase M, Tsuchihashi K, Miura T
    BMJ open 2 2012年 [査読有り]
  • Role of ER stress in ventricular contractile dysfunction in type 2 diabetes.
    Takada A, Miki T, Kuno A, Kouzu H, Sunaga D, Itoh T, Tanno M, Yano T, Sato T, Ishikawa S, Miura T
    PloS one 7 e39893 2012年 [査読有り]
  • Quantitative measurement of circumferential carotid arterial strain by two-dimensional speckle tracking imaging in healthy subjects.
    Yuda S, Kaneko R, Muranaka A, Hashimoto A, Tsuchihashi K, Miura T, Watanabe N, Shimamoto K
    Echocardiography (Mount Kisco, N.Y.) 28 899-906 2011年09月 [査読有り]
  • Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy.
    Hori YS, Kuno A, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
    The Journal of pharmacology and experimental therapeutics 338 784-794 2011年09月 [査読有り]
  • Left ventricular hypertrophy causes different changes in longitudinal, radial, and circumferential mechanics in patients with hypertension: a two-dimensional speckle tracking study.
    Kouzu H, Yuda S, Muranaka A, Doi T, Yamamoto H, Shimoshige S, Hase M, Hashimoto A, Saitoh S, Tsuchihashi K, Miura T, Watanabe N, Shimamoto K
    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 24 192-199 2011年02月 [査読有り]
  • Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection.
    Yano T, Miki T, Tanno M, Kuno A, Itoh T, Takada A, Sato T, Kouzu H, Shimamoto K, Miura T
    Hypertension 57 110-115 2011年01月 [査読有り]
  • Deterioration of renal function by chronic heart failure is associated with congestion and oxidative stress in the tubulointerstitium.
    Tanaka M, Yoshida H, Furuhashi M, Togashi N, Koyama M, Yamamoto S, Yamashita T, Okazaki Y, Ishimura S, Ota H, Hasegawa T, Miura T
    Internal medicine (Tokyo, Japan) 50 2877-2887 2011年 [査読有り]
  • Lipid chaperones and metabolic inflammation.
    Furuhashi M, Ishimura S, Ota H, Miura T
    International journal of inflammation 2011 642612 2011年 [査読有り]
  • Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease.
    Furuhashi M, Ishimura S, Ota H, Hayashi M, Nishitani T, Tanaka M, Yoshida H, Shimamoto K, Hotamisligil GS, Miura T
    PloS one 6 e27356 2011年 [査読有り]
  • Erythropoietin (EPO) affords more potent cardioprotection by activation of distinct signaling to mitochondrial kinases compared with carbamylated EPO.
    Sato T, Tanno M, Miki T, Yano T, Sato T, Shimamoto K, Miura T
    Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 24 401-408 2010年12月 [査読有り]
  • Cytoskeletal proteins: hidden targets of cytoprotective signaling?
    Miura T
    Circulation journal : official journal of the Japanese Circulation Society 74 2295-2296 2010年11月 [査読有り]
  • Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel.
    Terashima Y, Sato T, Yano T, Maas O, Itoh T, Miki T, Tanno M, Kuno A, Shimamoto K, Miura T
    Journal of molecular and cellular cardiology 49 762-770 2010年11月 [査読有り]
  • Mitochondrial kinase signalling pathways in myocardial protection from ischaemia/reperfusion-induced necrosis.
    Miura T, Tanno M, Sato T
    Cardiovascular research 88 7-15 2010年10月 [査読有り]
  • Mitochondria and GSK-3beta in cardioprotection against ischemia/reperfusion injury.
    Miura T, Tanno M
    Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 24 255-263 2010年06月 [査読有り]
  • Role of the gap junction in ischemic preconditioning in the heart.
    Miura T, Miki T, Yano T
    American journal of physiology. Heart and circulatory physiology 298 H1115-25 2010年04月 [査読有り]
  • Epicardium and pericardium: a joint force for infarct repair?
    Miura T
    Journal of molecular and cellular cardiology 48 579-581 2010年04月 [査読有り]
  • Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
    Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, Horio Y
    The Journal of biological chemistry 285 8375-8382 2010年03月 [査読有り]
  • Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts.
    Hotta H, Miura T, Miki T, Togashi N, Maeda T, Kim SJ, Tanno M, Yano T, Kuno A, Itoh T, Satoh T, Terashima Y, Ishikawa S, Shimamoto K
    Circulation research 106 129-132 2010年01月 [査読有り]
  • Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition.
    Miki T, Miura T, Hotta H, Tanno M, Yano T, Sato T, Terashima Y, Takada A, Ishikawa S, Shimamoto K
    Diabetes 58 2863-2872 2009年12月 [査読有り]
  • GSK-3beta, a therapeutic target for cardiomyocyte protection.
    Miura T, Miki T
    Circulation journal : official journal of the Japanese Circulation Society 73 1184-1192 2009年07月 [査読有り]
  • Are treatment effects of ACEI and ARB in post-MI patients homogeneous?
    Miura T, Yuda S
    Circulation journal : official journal of the Japanese Circulation Society 73 820-821 2009年05月 [査読有り]
  • Quantitative assessment of left ventricular and left atrial functions by strain rate imaging in diabetic patients with and without hypertension.
    Muranaka A, Yuda S, Tsuchihashi K, Hashimoto A, Nakata T, Miura T, Tsuzuki M, Wakabayashi C, Watanabe N, Shimamoto K
    Echocardiography (Mount Kisco, N.Y.) 26 262-271 2009年03月 [査読有り]
  • Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in myocardial protection against ischemia/reperfusion injury.
    Miura T, Nishihara M, Miki T
    Journal of pharmacological sciences 109 162-167 2009年02月 [査読有り]
  • Roles of Cx43-associated protein kinases in suppression of gap junction-mediated chemical coupling by ischemic preconditioning.
    Naitoh K, Yano T, Miura T, Itoh T, Miki T, Tanno M, Sato T, Hotta H, Terashima Y, Shimamoto K
    American journal of physiology. Heart and circulatory physiology 296 H396-403 2009年02月 [査読有り]
  • Ser9 phosphorylation of mitochondrial GSK-3beta is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis.
    Ohori K, Miura T, Tanno M, Miki T, Sato T, Ishikawa S, Horio Y, Shimamoto K
    American journal of physiology. Heart and circulatory physiology 295 H2079-86 2008年11月 [査読有り]
  • Limitation of myocardial infarct size in the clinical setting: current status and challenges in translating animal experiments into clinical therapy.
    Miura T, Miki T
    Basic research in cardiology 103 501-513 2008年11月 [査読有り]
  • Adenine nucleotide translocator, a mitochondrial carrier protein, and fate of cardiomyocytes after ischaemia/reperfusion.
    Tanno M, Miura T
    Cardiovascular research 80 1-2 2008年10月 [査読有り]
  • Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse.
    Nishino Y, Webb IG, Davidson SM, Ahmed AI, Clark JE, Jacquet S, Shah AM, Miura T, Yellon DM, Avkiran M, Marber MS
    Circulation research 103 307-314 2008年08月 [査読有り]
  • Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion.
    Kobayashi H, Miura T, Ishida H, Miki T, Tanno M, Yano T, Sato T, Hotta H, Shimamoto K
    Clinical and experimental pharmacology & physiology 35 812-819 2008年07月 [査読有り]
  • Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients.
    Fujii N, Tsuchihashi K, Sasao H, Eguchi M, Miurakami H, Hase M, Higashiura K, Yuda S, Hashimoto A, Miura T, Ura N, Shimamoto K
    Heart and vessels 23 9-15 2008年01月 [査読有り]
  • Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection.
    Nishihara M, Miura T, Miki T, Tanno M, Yano T, Naitoh K, Ohori K, Hotta H, Terashima Y, Shimamoto K
    Journal of molecular and cellular cardiology 43 564-570 2007年11月 [査読有り]
  • Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43.
    Miura T, Yano T, Naitoh K, Nishihara M, Miki T, Tanno M, Shimamoto K
    American journal of physiology. Heart and circulatory physiology 293 H1425-31 2007年09月 [査読有り]
  • Protecting ischemic hearts by modulation of SR calcium handling.
    Tanno M, Miura T
    Cardiovascular research 75 453-454 2007年08月 [査読有り]
  • Visceral obesity in Japanese patients with metabolic syndrome: reappraisal of diagnostic criteria by CT scan.
    Eguchi M, Tsuchihashi K, Saitoh S, Odawara Y, Hirano T, Nakata T, Miura T, Ura N, Hareyama M, Shimamoto K
    Hypertension research : official journal of the Japanese Society of Hypertension 30 315-323 2007年04月 [査読有り]
  • Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1.
    Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y
    The Journal of biological chemistry 282 6823-6832 2007年03月 [査読有り]
  • Impairment of cardioprotective PI3K-Akt signaling by post-infarct ventricular remodeling is compensated by an ERK-mediated pathway.
    Miki T, Miura T, Tanno M, Nishihara M, Naitoh K, Sato T, Takahashi A, Shimamoto K
    Basic research in cardiology 102 163-170 2007年03月 [査読有り]
  • Noninvasive assessment of left atrial function by strain rate imaging in patients with hypertension: a possible beneficial effect of renin-angiotensin system inhibition on left atrial function.
    Kokubu N, Yuda S, Tsuchihashi K, Hashimoto A, Nakata T, Miura T, Ura N, Nagao K, Tsuzuki M, Wakabayashi C, Shimamoto K
    Hypertension research : official journal of the Japanese Society of Hypertension 30 13-21 2007年01月 [査読有り]
  • Impact of abnormal glucose tolerance, hypertension and other risk factors on coronary artery disease.
    Nakamura Y, Saitoh S, Takagi S, Ohnishi H, Chiba Y, Kato N, Akasaka H, Miura T, Tsuchihashi K, Shimamoto K
    Circulation journal : official journal of the Japanese Circulation Society 71 20-25 2007年01月 [査読有り]
  • Clinical pathology and treatment of renin-angiotensin system 4. Renin-angiotensin system and insulin resistance.
    Shimamoto K, Miura T
    Internal medicine (Tokyo, Japan) 46 1303-1304 2007年 [査読有り]
  • Assessment of left ventricular ejection fraction using long-axis systolic function is independent of image quality: a study of tissue Doppler imaging and m-mode echocardiography.
    Yuda S, Inaba Y, Fujii S, Kokubu N, Yoshioka T, Sakurai S, Nishizato K, Fujii N, Hashimoto A, Uno K, Nakata T, Tsuchihashi K, Miura T, Ura N, Natori H, Shimamoto K
    Echocardiography (Mount Kisco, N.Y.) 23 846-852 2006年11月 [査読有り]
  • Persistent insulin-sensitizing effects of sarpogrelate hydrochloride, a serotonin 2A receptor antagonist, in patients with peripheral arterial disease.
    Kokubu N, Tsuchihashi K, Yuda S, Hase M, Eguchi M, Wakabayashi T, Hashimoto A, Nakata T, Miura T, Ura N, Nagao K, Tsuzuki M, Wakabayashi C, Shimamoto K
    Circulation journal : official journal of the Japanese Circulation Society 70 1451-1456 2006年11月 [査読有り]
  • Long-term outcome of implanted cardioverter defibrillators in survivors of out-of-hospital cardiac arrest of cardiac origin.
    Nagahara D, Hase M, Tsuchihashi K, Kokubu N, Sakurai S, Yoshioka T, Nishizato K, Fujii N, Uno K, Miura T, Ura N, Asai Y, Shimamoto K
    Circulation journal : official journal of the Japanese Circulation Society 70 1128-1132 2006年09月 [査読有り]
  • Activation of ERK and suppression of calcineurin are interacting mechanisms of cardioprotection afforded by delta-opioid receptor activation.
    Ikeda Y, Miura T, Sakamoto J, Miki T, Tanno M, Kobayashi H, Ohori K, Takahashi A, Shimamoto K
    Basic research in cardiology 101 418-426 2006年09月 [査読有り]
  • Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta.
    Nishihara M, Miura T, Miki T, Sakamoto J, Tanno M, Kobayashi H, Ikeda Y, Ohori K, Takahashi A, Shimamoto K
    American journal of physiology. Heart and circulatory physiology 291 H748-55 2006年08月 [査読有り]
  • MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism.
    Naitoh K, Ichikawa Y, Miura T, Nakamura Y, Miki T, Ikeda Y, Kobayashi H, Nishihara M, Ohori K, Shimamoto K
    Cardiovascular research 70 374-383 2006年05月 [査読有り]
  • Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodeling.
    Miki T, Miura T, Yano T, Takahashi A, Sakamoto J, Tanno M, Kobayashi H, Ikeda Y, Nishihara M, Naitoh K, Ohori K, Shimamoto K
    The Journal of pharmacology and experimental therapeutics 317 68-75 2006年04月 [査読有り]
  • Macrophage colony-stimulating factor treatment after myocardial infarction attenuates left ventricular dysfunction by accelerating infarct repair.
    Yano T, Miura T, Whittaker P, Miki T, Sakamoto J, Nakamura Y, Ichikawa Y, Ikeda Y, Kobayashi H, Ohori K, Shimamoto K
    Journal of the American College of Cardiology 47 626-634 2006年02月 [査読有り]
  • Early defibrillation and circulatory support can provide better long-term outcomes through favorable neurological recovery in patients with out-of-hospital cardiac arrest of cardiac origin.
    Hase M, Tsuchihashi K, Fujii N, Nishizato K, Kokubu N, Nara S, Kurimoto Y, Hashimoto A, Uno K, Miura T, Ura N, Asai Y, Shimamoto K
    Circulation journal : official journal of the Japanese Circulation Society 69 1302-1307 2005年11月 [査読有り]
  • Intracardiac fibroblasts, but not bone marrow derived cells, are the origin of myofibroblasts in myocardial infarct repair.
    Yano T, Miura T, Ikeda Y, Matsuda E, Saito K, Miki T, Kobayashi H, Nishino Y, Ohtani S, Shimamoto K
    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 14 241-246 2005年09月 [査読有り]
  • Development and progression of atherosclerotic disease in relation to insulin resistance and hyperinsulinemia.
    Fujiwara T, Saitoh S, Takagi S, Takeuchi H, Isobe T, Chiba Y, Miura T, Shimamoto K
    Hypertension research : official journal of the Japanese Society of Hypertension 28 665-670 2005年08月 [査読有り]
  • Strain rate imaging for noninvasive functional quantification of the left atrium: comparative studies in controls and patients with atrial fibrillation.
    Inaba Y, Yuda S, Kobayashi N, Hashimoto A, Uno K, Nakata T, Tsuchihashi K, Miura T, Ura N, Shimamoto K
    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 18 729-736 2005年07月 [査読有り]
  • Granulocyte colony stimulating factor/macrophage colony stimulating factor improves postinfarct ventricular function by suppression of border zone remodelling in rats.
    Miki T, Miura T, Nishino Y, Yano T, Sakamoto J, Nakamura Y, Ichikawa Y, Ikeda Y, Kobayashi H, Ura N, Shimamoto K
    Clinical and experimental pharmacology & physiology 31 873-882 2004年12月 [査読有り]
  • Role of microtubules in ischemic preconditioning against myocardial infarction.
    Nakamura Y, Miura T, Nakano A, Ichikawa Y, Yano T, Kobayashi H, Ikeda Y, Miki T, Shimamoto K
    Cardiovascular research 64 322-330 2004年11月 [査読有り]
  • The role of ADAM protease in the tyrosine kinase-mediated trigger mechanism of ischemic preconditioning.
    Ichikawa Y, Miura T, Nakano A, Miki T, Nakamura Y, Tsuchihashi K, Shimamoto K
    Cardiovascular research 62 167-175 2004年04月 [査読有り]
  • Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection.
    Nishino Y, Miura T, Miki T, Sakamoto J, Nakamura Y, Ikeda Y, Kobayashi H, Shimamoto K
    Cardiovascular research 61 610-619 2004年02月 [査読有り]
  • Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.
    Sakamoto J, Miura T, Shimamoto K, Horio Y
    FEBS letters 556(1/3) 281-286 2004年01月 [査読有り]
  • Protective role of gap junctions in preconditioning against myocardial infarction.
    Miura T, Ohnuma Y, Kuno A, Tanno M, Ichikawa Y, Nakamura Y, Yano T, Miki T, Sakamoto J, Shimamoto K
    American journal of physiology. Heart and circulatory physiology 286 H214-21 2004年01月 [査読有り]
  • ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart.
    Miura T, Miki T
    Current vascular pharmacology 1 251-258 2003年10月 [査読有り]
  • Role of adiponectin in insulin-resistant hypertension and atherosclerosis.
    Murakami H, Ura N, Furuhashi M, Higashiura K, Miura T, Shimamoto K
    Hypertension research : official journal of the Japanese Society of Hypertension 26(9) 705-710 2003年09月 [査読有り]
  • Myocardial response to ischemic preconditioning: is it a novel predictor of prognosis?
    Miura T
    Journal of the American College of Cardiology 42 1004-1006 2003年09月 [査読有り]
  • Does enhanced expression of the Na+-Ca2+ exchanger increase myocardial vulnerability to ischemia/reperfusion injury in rabbit hearts?
    Matsumoto T, Miura T, Miki T, Nishino Y, Nakamura Y, Shimamoto K
    Molecular and cellular biochemistry 248(1-2) 141-147 2003年06月 [査読有り]
  • Interruption of signal transduction between G protein and PKC-epsilon underlies the impaired myocardial response to ischemic preconditioning in postinfarct remodeled hearts.
    Miki T, Miura T, Tanno M, Sakamoto J, Kuno A, Genda S, Matsumoto T, Ichikawa Y, Shimamoto K
    Molecular and cellular biochemistry 247(1-2) 185-193 2003年05月 [査読有り]
  • Mitochondrial KATP channel-dependent and -independent phases of ischemic preconditioning against myocardial infarction in the rat.
    Nozawa Y, Miura T, Miki T, Ohnuma Y, Yano T, Shimamoto K
    Basic research in cardiology 98 50-58 2003年02月 [査読有り]
  • Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C.
    Tsuchida A, Miura T, Tanno M, Sakamoto J, Miki T, Kuno A, Matsumoto T, Ohnuma Y, Ichikawa Y, Shimamoto K
    Journal of the American College of Cardiology 40 1523-1530 2002年10月 [査読有り]
  • K(ATP) channel opening is an endogenous mechanism of protection against the no-reflow phenomenon but its function is compromised by hypercholesterolemia.
    Genda S, Miura T, Miki T, Ichikawa Y, Shimamoto K
    Journal of the American College of Cardiology 40 1339-1346 2002年10月 [査読有り]
  • Effects of neutral endopeptidase 24.11 inhibition on myocardial infarct size and ischemic preconditioning in rabbits.
    Nakano A, Miura T, Miki T, Nozawa Y, Ichikawa Y, Ura N, Shimamoto K
    Naunyn-Schmiedeberg's archives of pharmacology 366 335-342 2002年10月 [査読有り]
  • Hepatocyte growth factor and 24-hour ambulatory blood pressure monitoring.
    Hayashi Y, Saitoh S, Takagi S, Tuchihashi K, Miura T, Shimamoto K
    Hypertension research : official journal of the Japanese Society of Hypertension 25(5) 655-660 2002年09月 [査読有り]
  • Sonoclot coagulation analysis: new bedside monitoring for determination of the appropriate heparin dose during haemodialysis.
    Furuhashi M, Ura N, Hasegawa K, Yoshida H, Tsuchihashi K, Miura T, Shimamoto K
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 17 1457-1462 2002年08月 [査読有り]
  • Blockade of the Na+-Ca2+ exchanger is more efficient than blockade of the Na+-H+ exchanger for protection of the myocardium from lethal reperfusion injury.
    Matsumoto T, Miura T, Miki T, Genda S, Shimamoto K
    Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 16 295-301 2002年07月 [査読有り]
  • Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning.
    Ohnuma Y, Miura T, Miki T, Tanno M, Kuno A, Tsuchida A, Shimamoto K
    American journal of physiology. Heart and circulatory physiology 283 H440-7 2002年07月 [査読有り]
  • Blockade of angiotensin II type 1 receptors suppressed free radical production and preserved coronary endothelial function in the rabbit heart after myocardial infarction.
    Kuno A, Miura T, Tsuchida A, Hasegawa T, Miki T, Nishino Y, Shimamoto K
    Journal of cardiovascular pharmacology 39 49-57 2002年01月 [査読有り]
  • Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction.
    Tsuchida A, Miura T, Miki T, Kuno A, Tanno M, Nozawa Y, Genda S, Matsumoto T, Shimamoto K
    Basic research in cardiology 96 446-453 2001年09月 [査読有り]
  • Contribution of both the sarcolemmal K(ATP) and mitochondrial K(ATP) channels to infarct size limitation by K(ATP) channel openers: differences from preconditioning in the role of sarcolemmal K(ATP) channels.
    Tanno M, Miura T, Tsuchida A, Miki T, Nishino Y, Ohnuma Y, Shimamoto K
    Naunyn-Schmiedeberg's archives of pharmacology 364 226-232 2001年09月 [査読有り]
  • Mitochondrial ATP-sensitive K+ channels play a role in cardioprotection by Na+-H+ exchange inhibition against ischemia/reperfusion injury.
    Miura T, Liu Y, Goto M, Tsuchida A, Miki T, Nakano A, Nishino Y, Ohnuma Y, Shimamoto K
    Journal of the American College of Cardiology 37 957-963 2001年03月 [査読有り]
  • Infarct size limitation by bradykinin receptor activation is mediated by the mitochondrial but not by the sarcolemmal K(ATP) channel.
    Kita H, Miura T, Miki T, Genda S, Tanno M, Fukuma T, Shimamoto K
    Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 14 497-502 2000年10月 [査読有り]
  • Relationship between free radicals and adenosine in the mechanism of preconditioning: are they interrelated or independent triggers?
    Fukuma T, Miura T, Suzuki K, Tsuchida A, Nozawa Y, Shimamoto K
    Molecular and cellular biochemistry 211 51-59 2000年08月 [査読有り]
  • Cardioprotective mechanism of ischemic preconditioning is impaired by postinfarct ventricular remodeling through angiotensin II type 1 receptor activation.
    Miki T, Miura T, Tsuchida A, Nakano A, Hasegawa T, Fukuma T, Shimamoto K
    Circulation 102 458-463 2000年07月 [査読有り]
  • Roles of tyrosine kinase and protein kinase C in infarct size limitation by repetitive ischemic preconditioning in the rat.
    Tanno M, Tsuchida A, Nozawa Y, Matsumoto T, Hasegawa T, Miura T, Shimamoto K
    Journal of cardiovascular pharmacology 35 345-352 2000年03月 [査読有り]
  • Roles of mitochondrial ATP-sensitive K channels and PKC in anti-infarct tolerance afforded by adenosine A1 receptor activation.
    Miura T, Liu Y, Kita H, Ogawa T, Shimamoto K
    Journal of the American College of Cardiology 35 238-245 2000年01月 [査読有り]
  • Evidence for the delayed effect in human ischemic preconditioning: prospective multicenter study for preconditioning in acute myocardial infarction.
    Noda T, Minatoguchi S, Fujii K, Hori M, Ito T, Kanmatsuse K, Matsuzaki M, Miura T, Nonogi H, Tada M, Tanaka M, Fujiwara H
    Journal of the American College of Cardiology 34(7) 1966-1974 1999年12月 [査読有り]
  • Reperfusion arrhythmias in the murine heart: their characteristics and alteration after ischemic preconditioning.
    Sakamoto J, Miura T, Tsuchida A, Fukuma T, Hasegawa T, Shimamoto K
    Basic research in cardiology 94 489-495 1999年12月 [査読有り]
  • Chronic treatment with an ACE inhibitor, temocapril, lowers the threshold for the infarct size-limiting effect of ischemic preconditioning.
    Nozawa Y, Miura T, Tsuchida A, Kita H, Fukuma T, Shimamoto K
    Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 13 151-157 1999年04月 [査読有り]
  • Adenosine and preconditioning revisited.
    Miura T, Tsuchida A
    Clinical and experimental pharmacology & physiology 26(2) 92-99 1999年02月 [査読有り]
  • Ecto-5'-nucleotidase is not required for ischemic preconditioning in rabbit myocardium in situ.
    Miki T, Miura T, Bünger R, Suzuki K, Sakamoto J, Shimamoto K
    The American journal of physiology 275 H1329-37 1998年10月 [査読有り]
  • Effect of protein kinase C inhibitors on cardioprotection by ischemic preconditioning depends on the number of preconditioning episodes.
    Miura T, Miura T, Kawamura S, Goto M, Sakamoto J, Tsuchida A, Matsuzaki M, Shimamoto K
    Cardiovascular research 37 700-709 1998年03月 [査読有り]
  • Infarct-size limitation by preconditioning is enhanced by dipyridamole administered before but not after preconditioning: evidence for the role of interstitial adenosine level during preconditioning as a primary determinant of cardioprotection.
    Suzuki K, Miura T, Miki T, Tsuchida A, Shimamoto K
    Journal of cardiovascular pharmacology 31 1-9 1998年01月 [査読有り]
  • Infarct size limitation by a new Na(+)-H+ exchange inhibitor, Hoe 642: difference from preconditioning in the role of protein kinase C.
    Miura T, Ogawa T, Suzuki K, Goto M, Shimamoto K
    Journal of the American College of Cardiology 29(3) 693-701 1997年03月 [査読有り]
  • Captopril potentiates the myocardial infarct size-limiting effect of ischemic preconditioning through bradykinin B2 receptor activation.
    Miki T, Miura T, Ura N, Ogawa T, Suzuki K, Shimamoto K, Iimura O
    Journal of the American College of Cardiology 28(6) 1616-1622 1996年11月 [査読有り]
  • Suppression of the degradation of adenine nucleotides during ischemia may not be a sufficient mechanism for infarct size limitation by preconditioning.
    Miura T, Suzuki K, Shimamoto K, Iimura O
    Basic research in cardiology 91 425-432 1996年11月 [査読有り]
  • Activation of adenosine receptors before ischemia enhances tolerance against myocardial stunning in the rabbit heart.
    Ogawa T, Miura T, Shimamoto K, Iimura O
    Journal of the American College of Cardiology 27(1) 225-233 1996年01月 [査読有り]
  • Adenosine and bradykinin: are they independent triggers of preconditioning?
    Miura T
    Basic research in cardiology 91 20-22 1996年01月 [査読有り]
  • Suppression of reperfusion arrhythmia by ischemic preconditioning in the rat: is it mediated by the adenosine receptor, prostaglandin, or bradykinin receptor?
    Miura T, Ishimoto R, Sakamoto J, Tsuchida A, Suzuki K, Ogawa T, Shimamoto K, Iimura O
    Basic research in cardiology 90 240-246 1995年05月 [査読有り]
  • Reduction of regional contractile function by preconditioning ischemia does not play a permissive role in the infarct size-limitation by the preconditioning.
    Goto M, Miura T, Itoya M, Sakamoto J, Iimura O
    Basic research in cardiology 88 594-606 1993年11月 [査読有り]
  • Preconditioning enhances myocardial resistance to postischaemic myocardial stunning via adenosine receptor activation.
    Urabe K, Miura T, Iwamoto T, Ogawa T, Goto M, Sakamoto J, Iimura O
    Cardiovascular research 27 657-662 1993年04月 [査読有り]
  • Infarct size limitation by preconditioning: its phenomenological features and the key role of adenosine.
    Miura T, Iimura O
    Cardiovascular research 27 36-42 1993年01月 [査読有り]
  • Dipyridamole potentiates the myocardial infarct size-limiting effect of ischemic preconditioning.
    Miura T, Ogawa T, Iwamoto T, Shimamoto K, Iimura O
    Circulation 86 979-985 1992年09月 [査読有り]
  • Role of adenosine receptor activation in myocardial infarct size limitation by ischaemic preconditioning.
    Tsuchida A, Miura T, Miki T, Shimamoto K, Iimura O
    Cardiovascular research 26 456-461 1992年05月 [査読有り]
  • Does myocardial stunning contribute to infarct size limitation by ischemic preconditioning?
    Miura T, Goto M, Urabe K, Endoh A, Shimamoto K, Iimura O
    Circulation 84 2504-2512 1991年12月 [査読有り]
  • Myocardial infarct size-limiting effect of ischemic preconditioning was not attenuated by oxygen free-radical scavengers in the rabbit.
    Iwamoto T, Miura T, Adachi T, Noto T, Ogawa T, Tsuchida A, Iimura O
    Circulation 83 1015-1022 1991年03月 [査読有り]

競争的資金等の研究課題

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    日本学術振興会
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  • ミトコンドリア透過性遷移孔を制御する蛋白キナーゼ系の解析
    日本学術振興会
    代表者 : 三浦 哲嗣
  • 心筋細胞保護シグナルにおけるコネキシン43の役割
    日本学術振興会
    代表者 : 三浦 哲嗣
  • 心筋細胞における虚血耐性因子としてのコネキシン43の役割
    日本学術振興会
    代表者 : 三浦 哲嗣
  • 虚血心筋におけるギャップ結合の機能ならびに蛋白発現を制御する細胞情報伝達機構
    日本学術振興会
    代表者 : 三浦 哲嗣
  • 心筋虚血におけるギャップ結合の調節と細胞壊死への関与の検討
    日本学術振興会
    代表者 : 三浦 哲嗣
  • ストレス蛋白質の誘導による虚血心筋細胞障害の抑制とその機序に関する研究
    日本学術振興会
    代表者 : 三浦 哲嗣
  • Preconditioningによる虚血心筋細胞障害抑制の機序に関する研究
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受賞

  • 2012年 北海道知事賞
  • 2012年 北海道医師会賞
  • 1991年 北海道心臓協会伊藤記念研究助成
受賞を全て表示する
受賞閉じる
  • 2012年 北海道知事賞
  • 2012年 北海道医師会賞
  • 1991年 北海道心臓協会伊藤記念研究助成


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