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塚原 智英 ツカハラ トモヒデ

所属部署名病理学第一講座
職名准教授ホームページURLhttps://kaken.nii.ac.jp/d/r/20404634.ja.html
更新日 :2017/11/18

プロフィール

研究キーワード

    軟部腫瘍学, HLA/ペプチド複合体, 骨肉腫抗原, 骨, ファージディスプレイライブラリ

研究分野

  • 外科系臨床医学 / 整形外科学

経歴

  • 2013年
    札幌医科大学 医学部(助教)

研究活動

論文

  • Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells.
    Tanaka T, Okuya K, Kutomi G, Takaya A, Kajiwara T, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Hirata K, Okamoto Y, Sato N, Tamura Y
    Cancer science 106 18-24 2015年01月 [査読有り]
  • A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.
    Sugita S, Arai Y, Tonooka A, Hama N, Totoki Y, Fujii T, Aoyama T, Asanuma H, Tsukahara T, Kaya M, Shibata T, Hasegawa T
    The American journal of surgical pathology 38 1571-1576 2014年11月 [査読有り]
  • Diagnostic utility of NCOA2 fluorescence in situ hybridization and Stat6 immunohistochemistry staining for soft tissue angiofibroma and morphologically similar fibrovascular tumors.
    Sugita S, Aoyama T, Kondo K, Keira Y, Ogino J, Nakanishi K, Kaya M, Emori M, Tsukahara T, Nakajima H, Takagi M, Hasegawa T
    Human pathology 45 1588-1596 2014年08月 [査読有り]
  • Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody.
    Tsukahara T, Emori M, Murata K, Hirano T, Muroi N, Kyono M, Toji S, Watanabe K, Torigoe T, Kochin V, Asanuma H, Matsumiya H, Yamashita K, Himi T, Ichimiya S, Wada T, Yamashita T, Hasegawa T, Sato N
    The Journal of biological chemistry 289 22035-22047 2014年08月 [査読有り]
  • Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells.
    Morita R, Nishizawa S, Torigoe T, Takahashi A, Tamura Y, Tsukahara T, Kanaseki T, Sokolovskaya A, Kochin V, Kondo T, Hashino S, Asaka M, Hara I, Hirohashi Y, Sato N
    Cancer science 105 389-395 2014年04月 [査読有り]
  • [The path to innovative drug development of cancer vaccine: from discovery of tumor antigens to clinical trials].
    Torigoe T, Hirohashi Y, Tsukahara T, Kanaseki T, Kochin V, Sato N
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 37 90-95 2014年 [査読有り]
  • Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.
    Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Fujino J, Tamura Y, Tsukahara T, Kanaseki T, Kobayashi J, Sasaki T, Takahashi A, Nakamori K, Yamaguchi A, Hiratsuka H, Sato N
    Biochemical and biophysical research communications 439 96-102 2013年09月 [査読有り]
  • Immunotherapeutic benefit of α-interferon (IFNα) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients.
    Kameshima H, Tsuruma T, Kutomi G, Shima H, Iwayama Y, Kimura Y, Imamura M, Torigoe T, Takahashi A, Hirohashi Y, Tamura Y, Tsukahara T, Kanaseki T, Sato N, Hirata K
    Cancer science 104 124-129 2013年01月 [査読有り]
  • Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.
    Takahashi A, Hirohashi Y, Torigoe T, Tamura Y, Tsukahara T, Kanaseki T, Kochin V, Saijo H, Kubo T, Nakatsugawa M, Asanuma H, Hasegawa T, Kondo T, Sato N
    PloS one 8 e69095 2013年 [査読有り]
  • High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in the novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma.
    Emori M, Tsukahara T, Murase M, Kano M, Murata K, Takahashi A, Kubo T, Asanuma H, Yasuda K, Kochin V, Kaya M, Nagoya S, Nishio J, Iwasaki H, Sonoda T, Hasegawa T, Torigoe T, Wada T, Yamashita T, Sato N
    PloS one 8 e84187 2013年 [査読有り]
論文を全て表示する
論文閉じる
  • Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells.
    Tanaka T, Okuya K, Kutomi G, Takaya A, Kajiwara T, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Hirata K, Okamoto Y, Sato N, Tamura Y
    Cancer science 106 18-24 2015年01月 [査読有り]
  • A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.
    Sugita S, Arai Y, Tonooka A, Hama N, Totoki Y, Fujii T, Aoyama T, Asanuma H, Tsukahara T, Kaya M, Shibata T, Hasegawa T
    The American journal of surgical pathology 38 1571-1576 2014年11月 [査読有り]
  • Diagnostic utility of NCOA2 fluorescence in situ hybridization and Stat6 immunohistochemistry staining for soft tissue angiofibroma and morphologically similar fibrovascular tumors.
    Sugita S, Aoyama T, Kondo K, Keira Y, Ogino J, Nakanishi K, Kaya M, Emori M, Tsukahara T, Nakajima H, Takagi M, Hasegawa T
    Human pathology 45 1588-1596 2014年08月 [査読有り]
  • Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody.
    Tsukahara T, Emori M, Murata K, Hirano T, Muroi N, Kyono M, Toji S, Watanabe K, Torigoe T, Kochin V, Asanuma H, Matsumiya H, Yamashita K, Himi T, Ichimiya S, Wada T, Yamashita T, Hasegawa T, Sato N
    The Journal of biological chemistry 289 22035-22047 2014年08月 [査読有り]
  • Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells.
    Morita R, Nishizawa S, Torigoe T, Takahashi A, Tamura Y, Tsukahara T, Kanaseki T, Sokolovskaya A, Kochin V, Kondo T, Hashino S, Asaka M, Hara I, Hirohashi Y, Sato N
    Cancer science 105 389-395 2014年04月 [査読有り]
  • [The path to innovative drug development of cancer vaccine: from discovery of tumor antigens to clinical trials].
    Torigoe T, Hirohashi Y, Tsukahara T, Kanaseki T, Kochin V, Sato N
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 37 90-95 2014年 [査読有り]
  • Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.
    Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Fujino J, Tamura Y, Tsukahara T, Kanaseki T, Kobayashi J, Sasaki T, Takahashi A, Nakamori K, Yamaguchi A, Hiratsuka H, Sato N
    Biochemical and biophysical research communications 439 96-102 2013年09月 [査読有り]
  • Immunotherapeutic benefit of α-interferon (IFNα) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients.
    Kameshima H, Tsuruma T, Kutomi G, Shima H, Iwayama Y, Kimura Y, Imamura M, Torigoe T, Takahashi A, Hirohashi Y, Tamura Y, Tsukahara T, Kanaseki T, Sato N, Hirata K
    Cancer science 104 124-129 2013年01月 [査読有り]
  • Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.
    Takahashi A, Hirohashi Y, Torigoe T, Tamura Y, Tsukahara T, Kanaseki T, Kochin V, Saijo H, Kubo T, Nakatsugawa M, Asanuma H, Hasegawa T, Kondo T, Sato N
    PloS one 8 e69095 2013年 [査読有り]
  • High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in the novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma.
    Emori M, Tsukahara T, Murase M, Kano M, Murata K, Takahashi A, Kubo T, Asanuma H, Yasuda K, Kochin V, Kaya M, Nagoya S, Nishio J, Iwasaki H, Sonoda T, Hasegawa T, Torigoe T, Wada T, Yamashita T, Sato N
    PloS one 8 e84187 2013年 [査読有り]
  • Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes.
    Takahashi A, Torigoe T, Tamura Y, Kanaseki T, Tsukahara T, Sasaki Y, Kameshima H, Tsuruma T, Hirata K, Tokino T, Hirohashi Y, Sato N
    Cell stress & chaperones 17 757-763 2012年11月 [査読有り]
  • SYT-SSX breakpoint peptide vaccines in patients with synovial sarcoma: a study from the Japanese Musculoskeletal Oncology Group.
    Kawaguchi S, Tsukahara T, Ida K, Kimura S, Murase M, Kano M, Emori M, Nagoya S, Kaya M, Torigoe T, Ueda E, Takahashi A, Ishii T, Tatezaki S, Toguchida J, Tsuchiya H, Osanai T, Sugita T, Sugiura H, Ieguchi M, Ihara K, Hamada K, Kakizaki H, Morii T, Yasuda T, Tanizawa T, Ogose A, Yabe H, Yamashita T, Sato N, Wada T
    Cancer science 103 1625-1630 2012年09月 [査読有り]
  • NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax.
    Tsukahara T, Takasawa A, Murata M, Okumura K, Nakayama M, Sato N, Hasegawa T
    Diagnostic pathology 7 114 2012年08月 [査読有り]
  • ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells.
    Matsuzaki J, Torigoe T, Hirohashi Y, Kamiguchi K, Tamura Y, Tsukahara T, Kubo T, Takahashi A, Nakazawa E, Saka E, Yasuda K, Takahashi S, Sato N
    Carcinogenesis 33 996-1003 2012年05月 [査読有り]
  • [Peptide vaccination therapy for bone and soft tissue sarcoma].
    Emori M, Tsukahara T, Kawaguchi S, Wada T
    Nihon rinsho. Japanese journal of clinical medicine 69 1670-1673 2011年09月 [査読有り]
  • Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma.
    Kano M, Tsukahara T, Emori M, Murase M, Torigoe T, Kawaguchi S, Wada T, Yamashita T, Sato N
    Cancer science 102 1443-1447 2011年08月 [査読有り]
  • Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients.
    Kameshima H, Tsuruma T, Torigoe T, Takahashi A, Hirohashi Y, Tamura Y, Tsukahara T, Ichimiya S, Kanaseki T, Iwayama Y, Sato N, Hirata K
    Cancer science 102 1181-1187 2011年06月 [査読有り]
  • Prognostic significance of HLA class I expression in Ewing's sarcoma family of tumors.
    Yabe H, Tsukahara T, Kawaguchi S, Wada T, Torigoe T, Sato N, Terai C, Aoki M, Hirose S, Morioka H, Yabe H
    Journal of surgical oncology 103 380-385 2011年04月 [査読有り]
  • HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor.
    Tsukahara T, Kawaguchi S, Torigoe T, Takahashi A, Murase M, Kano M, Wada T, Kaya M, Nagoya S, Yamashita T, Sato N
    Journal of translational medicine 7 44 2009年06月 [査読有り]
  • Molecular pathological approaches to human tumor immunology.
    Sato N, Hirohashi Y, Tsukahara T, Kikuchi T, Sahara H, Kamiguchi K, Ichimiya S, Tamura Y, Torigoe T
    Pathology international 59 205-217 2009年04月 [査読有り]
  • Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma.
    Tsukahara T, Kimura S, Ichimiya S, Torigoe T, Kawaguchi S, Wada T, Yamashita T, Sato N
    Cancer science 100 47-53 2009年01月 [査読有り]
  • Clonal T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206.
    Kimura S, Kozakai Y, Kawaguchi S, Tsukahara T, Ida K, Murase M, Matsumura T, Kaya M, Torigoe T, Wada T, Sato N, Yamashita T
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society 26 271-278 2008年02月 [査読有り]
  • Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma.
    Tsukahara T, Kawaguchi S, Torigoe T, Kimura S, Murase M, Ichimiya S, Wada T, Kaya M, Nagoya S, Ishii T, Tatezaki S, Yamashita T, Sato N
    Cancer science 99 368-375 2008年02月 [査読有り]
  • Overexpression of papillomavirus binding factor in Ewing's sarcoma family of tumors conferring poor prognosis.
    Yabe H, Tsukahara T, Kawaguchi S, Wada T, Sato N, Morioka H, Yabe H
    Oncology reports 19 129-134 2008年01月 [査読有り]
  • Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system.
    Ishikura H, Ikeda H, Abe H, Ohkuri T, Hiraga H, Isu K, Tsukahara T, Sato N, Kitamura H, Iwasaki N, Takeda N, Minami A, Nishimura T
    International journal of oncology 30 461-467 2007年02月 [査読有り]
  • Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5.
    Tsukahara T, Kawaguchi S, Torigoe T, Asanuma H, Nakazawa E, Shimozawa K, Nabeta Y, Kimura S, Kaya M, Nagoya S, Wada T, Yamashita T, Sato N
    Cancer science 97 1374-1380 2006年12月 [査読有り]
  • HLA-restricted specific tumor cytolysis by autologous T-lymphocytes infiltrating metastatic bone malignant fibrous histiocytoma of lymph node.
    Tsukahara T, Kawaguchi S, Ida K, Kimura S, Tamura Y, Ikeda T, Torigoe T, Nagoya S, Wada T, Sato N, Yamashita T
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society 24 94-101 2006年01月 [査読有り]
  • A quest for therapeutic antigens in bone and soft tissue sarcoma.
    Kawaguchi S, Wada T, Tsukahara T, Ida K, Torigoe T, Sato N, Yamashita T
    Journal of translational medicine 3 31 2005年08月 [査読有り]
  • Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in lung cancer.
    Hariu H, Hirohashi Y, Torigoe T, Asanuma H, Hariu M, Tamura Y, Aketa K, Nabeta C, Nakanishi K, Kamiguchi K, Mano Y, Kitamura H, Kobayashi J, Tsukahara T, Shijubo N, Sato N
    Clinical cancer research : an official journal of the American Association for Cancer Research 11 1000-1009 2005年02月 [査読有り]
  • Phase I vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma.
    Kawaguchi S, Wada T, Ida K, Sato Y, Nagoya S, Tsukahara T, Kimura S, Sahara H, Ikeda H, Shimozawa K, Asanuma H, Torigoe T, Hiraga H, Ishii T, Tatezaki SI, Sato N, Yamashita T
    Journal of translational medicine 3 1 2005年01月 [査読有り]
  • Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor.
    Tsukahara T, Nabeta Y, Kawaguchi S, Ikeda H, Sato Y, Shimozawa K, Ida K, Asanuma H, Hirohashi Y, Torigoe T, Hiraga H, Nagoya S, Wada T, Yamashita T, Sato N
    Cancer research 64 5442-5448 2004年08月 [査読有り]
  • Crisscross CTL induction by SYT-SSX junction peptide and its HLA-A*2402 anchor substitute.
    Ida K, Kawaguchi S, Sato Y, Tsukahara T, Nabeta Y, Sahara H, Ikeda H, Torigoe T, Ichimiya S, Kamiguchi K, Wada T, Nagoya S, Hiraga H, Kawai A, Ishii T, Araki N, Myoui A, Matsumoto S, Ozaki T, Yoshikawa H, Yamashita T, Sato N
    Journal of immunology (Baltimore, Md. : 1950) 173 1436-1443 2004年07月 [査読有り]
  • Simultaneous radial closing wedge and ulnar shortening osteotomies for distal radius malunion.
    Wada T, Isogai S, Kanaya K, Tsukahara T, Yamashita T
    The Journal of hand surgery 29 264-272 2004年03月 [査読有り]
  • Recognition by cellular and humoral autologous immunity in a human osteosarcoma cell line.
    Nabeta Y, Kawaguchi S, Sahara H, Ikeda H, Hirohashi Y, Goroku T, Sato Y, Tsukahara T, Torigoe T, Wada T, Kaya M, Hiraga H, Isu K, Yamawaki S, Ishii S, Yamashita T, Sato N
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 8 554-559 2003年 [査読有り]
  • Improved generation of HLA class I/peptide tetramers.
    Sato Y, Sahara H, Tsukahara T, Kondo M, Hirohashi Y, Nabeta Y, Kawaguchi S, Ikeda H, Torigoe T, Ichimiya S, Tamura Y, Wada T, Yamashita T, Goto M, Takasu H, Sato N
    Journal of immunological methods 271 177-184 2002年12月 [査読有り]
  • Detection and induction of CTLs specific for SYT-SSX-derived peptides in HLA-A24(+) patients with synovial sarcoma.
    Sato Y, Nabeta Y, Tsukahara T, Hirohashi Y, Syunsui R, Maeda A, Sahara H, Ikeda H, Torigoe T, Ichimiya S, Wada T, Yamashita T, Hiraga H, Kawai A, Ishii T, Araki N, Myoui A, Matsumoto S, Umeda T, Ishii S, Kawaguchi S, Sato N
    Journal of immunology (Baltimore, Md. : 1950) 169 1611-1618 2002年08月 [査読有り]

MISC

  • ビギナーズセミナー7  わかる!がん免疫とがん抗原
    塚原 智英
    日本臨床免疫学会会誌 37(4) 299-299 2014年
  • 合同シンポジウム2-5  がんワクチン創薬への道程:がん抗原の同定から臨床試験まで
    鳥越 俊彦, 廣橋 良彦, 塚原 智英, 島 宏彰, 水口 徹, 平田 公一, 佐藤 昇志
    日本臨床免疫学会会誌 36(5) 313-313 2013年
  • 中高年者の橈骨遠位端骨折変形治癒に対する矯正骨切り術 : 橈骨 closing wedge osteotomy と尺骨短縮術の併用
    和田 卓郎, 磯貝 哲, 塚原 智英, 相木 比古乃, 金谷 耕平, 青木 光広
    日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 21(2) 61-64 2004年10月
  • 手指PIP関節重度屈曲拘縮に対する手術療法の経験
    塚原 智英, 和田 卓郎, 土田 芳彦, 佐藤 攻, 磯貝 哲, 青木 光広, 石井 清一
    日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 18(5) 615-619 2002年02月
  • 手根管症候群における母指球部の知覚評価
    和田 卓郎, 磯貝 哲, 塚原 智英, 石井 清一, 青木 光広
    日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 18(5) 721-723 2002年02月
  • 難治性テニス肘のMRI所見と手術所見の検討
    青木 光広, 佐藤 攻, 塚原 智英, 和田 卓郎, 石井 清一
    日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 18(5) 728-732 2002年02月
  • 前骨間神経麻痺の自然経過と長期予後
    塚原 智英, 和田 卓郎, 北村 三穂, 青木 光広, 石井 清一
    日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 17(4) 411-413 2000年12月
  • 肩関節 antero-superior corner 損傷による前(上)方不安定症の1例
    福島 直, 岡村 健司, 木村 明彦, 塚原 智英
    関節鏡 = ARTHROSCOPY Society magazine guidance & Contribution rules 22(3) 1997年11月
MISCを全て表示する
  • ビギナーズセミナー7  わかる!がん免疫とがん抗原
    塚原 智英
    日本臨床免疫学会会誌 37(4) 299-299 2014年
  • 合同シンポジウム2-5  がんワクチン創薬への道程:がん抗原の同定から臨床試験まで
    鳥越 俊彦, 廣橋 良彦, 塚原 智英, 島 宏彰, 水口 徹, 平田 公一, 佐藤 昇志
    日本臨床免疫学会会誌 36(5) 313-313 2013年
  • 中高年者の橈骨遠位端骨折変形治癒に対する矯正骨切り術 : 橈骨 closing wedge osteotomy と尺骨短縮術の併用
    和田 卓郎, 磯貝 哲, 塚原 智英, 相木 比古乃, 金谷 耕平, 青木 光広
    日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 21(2) 61-64 2004年10月
  • 手指PIP関節重度屈曲拘縮に対する手術療法の経験
    塚原 智英, 和田 卓郎, 土田 芳彦, 佐藤 攻, 磯貝 哲, 青木 光広, 石井 清一
    日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 18(5) 615-619 2002年02月
  • 手根管症候群における母指球部の知覚評価
    和田 卓郎, 磯貝 哲, 塚原 智英, 石井 清一, 青木 光広
    日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 18(5) 721-723 2002年02月
  • 難治性テニス肘のMRI所見と手術所見の検討
    青木 光広, 佐藤 攻, 塚原 智英, 和田 卓郎, 石井 清一
    日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 18(5) 728-732 2002年02月
  • 前骨間神経麻痺の自然経過と長期予後
    塚原 智英, 和田 卓郎, 北村 三穂, 青木 光広, 石井 清一
    日本手の外科学会雑誌 = The Journal of Japanese Society for Surgery of the Hand 17(4) 411-413 2000年12月
  • 肩関節 antero-superior corner 損傷による前(上)方不安定症の1例
    福島 直, 岡村 健司, 木村 明彦, 塚原 智英
    関節鏡 = ARTHROSCOPY Society magazine guidance & Contribution rules 22(3) 1997年11月


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