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能正 勝彦 ノウショウ カツヒコ

所属部署名消化器内科学講座
職名講師ホームページURLhttps://kaken.nii.ac.jp/d/r/10597339.ja.html
更新日 :2017/09/13

プロフィール

研究キーワード

    大腸癌, microRNA, 下部消化管学(小腸、大腸), 大腸鋸歯状病変, メチル化, マイクロRNA, DNAメチル化, 胃癌, 分子疫学, LINE-1, 機能性RNA, miR-196a, 食道扁平上皮癌, 背景粘膜, HOTAIR, エピゲノム, SNP, DNA, 消化管癌, GIST, MCA microarray, 粘膜内癌

研究分野

  • 内科系臨床医学 / 消化器内科学
  • 腫瘍学 / がん疫学・予防
  • 腫瘍学 / 腫瘍診断学

経歴

  • 2011年
    -
    2012年
    札幌医科大学 医学部(助教)

学位

  • 医学博士(札幌医科大学大学院)

研究活動

論文

  • Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
    Song M, Nishihara R, Wang M, Chan AT, Qian ZR, Inamura K, Zhang X, Ng K, Kim SA, Mima K, Sukawa Y, Nosho K, Fuchs CS, Giovannucci EL, Wu K, Ogino S
    Gut 2015年01月 [査読有り]
  • MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.
    Ito M, Mitsuhashi K, Igarashi H, Nosho K, Naito T, Yoshii S, Takahashi H, Fujita M, Sukawa Y, Yamamoto E, Takahashi T, Adachi Y, Nojima M, Sasaki Y, Tokino T, Baba Y, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y
    International journal of cancer. Journal international du cancer 135 2507-2515 2014年12月 [査読有り]
  • Association of MicroRNA-31-5p with Clinical Efficacy of Anti-EGFR Therapy in Patients with Metastatic Colorectal Cancer.
    Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y
    Annals of surgical oncology 2014年12月 [査読有り]
  • MicroRNA-31 expression in colorectal serrated pathway progression.
    Aoki H, Nosho K, Igarashi H, Ito M, Mitsuhashi K, Naito T, Yamamoto E, Tanuma T, Nomura M, Maguchi H, Shinohara T, Suzuki H, Yamamoto H, Shinomura Y
    World journal of gastroenterology : WJG 20 12346-12349 2014年09月 [査読有り]
  • IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.
    Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y
    World journal of gastroenterology : WJG 20 10050-10061 2014年08月 [査読有り]
  • Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.
    Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y
    Journal of gastroenterology 49 1135-1144 2014年07月 [査読有り]
  • Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.
    Imamura Y, Lochhead P, Yamauchi M, Kuchiba A, Qian ZR, Liao X, Nishihara R, Jung S, Wu K, Nosho K, Wang YE, Peng S, Bass AJ, Haigis KM, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S
    Molecular cancer 13 135 2014年05月 [査読有り]
  • Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway.
    Nosho K, Igarashi H, Nojima M, Ito M, Maruyama R, Yoshii S, Naito T, Sukawa Y, Mikami M, Sumioka W, Yamamoto E, Kurokawa S, Adachi Y, Takahashi H, Okuda H, Kusumi T, Hosokawa M, Fujita M, Hasegawa T, Okita K, Hirata K, Suzuki H, Yamamoto H, Shinomura Y
    Carcinogenesis 35 776-783 2014年04月 [査読有り]
  • An updated review of gastric cancer in the next-generation sequencing era: insights from bench to bedside and vice versa.
    Yamamoto H, Watanabe Y, Maehata T, Morita R, Yoshida Y, Oikawa R, Ishigooka S, Ozawa S, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, Suzuki H, Yasuda H, Shinomura Y, Itoh F
    World journal of gastroenterology : WJG 20 3927-3937 2014年04月 [査読有り]
  • Factors associated with risk for colorectal cancer recurrence after endoscopic resection of T1 tumors.
    Yoshii S, Nojima M, Nosho K, Omori S, Kusumi T, Okuda H, Tsukagoshi H, Fujita M, Yamamoto H, Hosokawa M
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 12 292-302.e3 2014年02月 [査読有り]
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  • Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
    Song M, Nishihara R, Wang M, Chan AT, Qian ZR, Inamura K, Zhang X, Ng K, Kim SA, Mima K, Sukawa Y, Nosho K, Fuchs CS, Giovannucci EL, Wu K, Ogino S
    Gut 2015年01月 [査読有り]
  • MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.
    Ito M, Mitsuhashi K, Igarashi H, Nosho K, Naito T, Yoshii S, Takahashi H, Fujita M, Sukawa Y, Yamamoto E, Takahashi T, Adachi Y, Nojima M, Sasaki Y, Tokino T, Baba Y, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y
    International journal of cancer. Journal international du cancer 135 2507-2515 2014年12月 [査読有り]
  • Association of MicroRNA-31-5p with Clinical Efficacy of Anti-EGFR Therapy in Patients with Metastatic Colorectal Cancer.
    Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y
    Annals of surgical oncology 2014年12月 [査読有り]
  • MicroRNA-31 expression in colorectal serrated pathway progression.
    Aoki H, Nosho K, Igarashi H, Ito M, Mitsuhashi K, Naito T, Yamamoto E, Tanuma T, Nomura M, Maguchi H, Shinohara T, Suzuki H, Yamamoto H, Shinomura Y
    World journal of gastroenterology : WJG 20 12346-12349 2014年09月 [査読有り]
  • IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.
    Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y
    World journal of gastroenterology : WJG 20 10050-10061 2014年08月 [査読有り]
  • Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.
    Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y
    Journal of gastroenterology 49 1135-1144 2014年07月 [査読有り]
  • Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.
    Imamura Y, Lochhead P, Yamauchi M, Kuchiba A, Qian ZR, Liao X, Nishihara R, Jung S, Wu K, Nosho K, Wang YE, Peng S, Bass AJ, Haigis KM, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S
    Molecular cancer 13 135 2014年05月 [査読有り]
  • Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway.
    Nosho K, Igarashi H, Nojima M, Ito M, Maruyama R, Yoshii S, Naito T, Sukawa Y, Mikami M, Sumioka W, Yamamoto E, Kurokawa S, Adachi Y, Takahashi H, Okuda H, Kusumi T, Hosokawa M, Fujita M, Hasegawa T, Okita K, Hirata K, Suzuki H, Yamamoto H, Shinomura Y
    Carcinogenesis 35 776-783 2014年04月 [査読有り]
  • An updated review of gastric cancer in the next-generation sequencing era: insights from bench to bedside and vice versa.
    Yamamoto H, Watanabe Y, Maehata T, Morita R, Yoshida Y, Oikawa R, Ishigooka S, Ozawa S, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, Suzuki H, Yasuda H, Shinomura Y, Itoh F
    World journal of gastroenterology : WJG 20 3927-3937 2014年04月 [査読有り]
  • Factors associated with risk for colorectal cancer recurrence after endoscopic resection of T1 tumors.
    Yoshii S, Nojima M, Nosho K, Omori S, Kusumi T, Okuda H, Tsukagoshi H, Fujita M, Yamamoto H, Hosokawa M
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 12 292-302.e3 2014年02月 [査読有り]
  • The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma.
    Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 35 973-985 2014年02月 [査読有り]
  • HER2 expression and PI3K-Akt pathway alterations in gastric cancer.
    Sukawa Y, Yamamoto H, Nosho K, Ito M, Igarashi H, Naito T, Mitsuhashi K, Matsunaga Y, Takahashi T, Mikami M, Adachi Y, Suzuki H, Shinomura Y
    Digestion 89 12-17 2014年 [査読有り]
  • A prospective study of duration of smoking cessation and colorectal cancer risk by epigenetics-related tumor classification.
    Nishihara R, Morikawa T, Kuchiba A, Lochhead P, Yamauchi M, Liao X, Imamura Y, Nosho K, Shima K, Kawachi I, Qian ZR, Fuchs CS, Chan AT, Giovannucci E, Ogino S
    American journal of epidemiology 178 84-100 2013年07月 [査読有り]
  • PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma.
    Shigaki H, Baba Y, Watanabe M, Murata A, Ishimoto T, Iwatsuki M, Iwagami S, Nosho K, Baba H
    Clinical cancer research : an official journal of the American Association for Cancer Research 19 2451-2459 2013年05月 [査読有り]
  • Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer.
    Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, Matsuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y
    World journal of gastroenterology : WJG 18 6577-6586 2012年12月 [査読有り]
  • Expression profiling of archival tumors for long-term health studies.
    Waldron L, Ogino S, Hoshida Y, Shima K, McCart Reed AE, Simpson PT, Baba Y, Nosho K, Segata N, Vargas AC, Cummings MC, Lakhani SR, Kirkner GJ, Giovannucci E, Quackenbush J, Golub TR, Fuchs CS, Parmigiani G, Huttenhower C
    Clinical cancer research : an official journal of the American Association for Cancer Research 18 6136-6146 2012年11月 [査読有り]
  • Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.
    Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, Imamura Y, Qian ZR, Baba Y, Shima K, Sun R, Nosho K, Meyerhardt JA, Giovannucci E, Fuchs CS, Chan AT, Ogino S
    The New England journal of medicine 367 1596-1606 2012年10月 [査読有り]
  • Submucosal hematoma is a highly suggestive finding for amyloid light-chain amyloidosis: Two case reports.
    Yoshii S, Mabe K, Nosho K, Yamamoto H, Yasui H, Okuda H, Suzuki A, Fujita M, Sato T
    World journal of gastrointestinal endoscopy 4 434-437 2012年09月 [査読有り]
  • Predictors of lymph node count in colorectal cancer resections: data from US nationwide prospective cohort studies.
    Morikawa T, Tanaka N, Kuchiba A, Nosho K, Yamauchi M, Hornick JL, Swanson RS, Chan AT, Meyerhardt JA, Huttenhower C, Schrag D, Fuchs CS, Ogino S
    Archives of surgery (Chicago, Ill. : 1960) 147 715-723 2012年08月 [査読有り]
  • Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression.
    Lin JH, Morikawa T, Chan AT, Kuchiba A, Shima K, Nosho K, Kirkner G, Zhang SM, Manson JE, Giovannucci E, Fuchs CS, Ogino S
    Cancer research 72 3020-3028 2012年06月 [査読有り]
  • Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.
    Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y
    World journal of gastroenterology : WJG 18 2745-2755 2012年06月 [査読有り]
  • Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and literature review.
    Liao X, Morikawa T, Lochhead P, Imamura Y, Kuchiba A, Yamauchi M, Nosho K, Qian ZR, Nishihara R, Meyerhardt JA, Fuchs CS, Ogino S
    Clinical cancer research : an official journal of the American Association for Cancer Research 18 2257-2268 2012年04月 [査読有り]
  • Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.
    Niinuma T, Suzuki H, Nojima M, Nosho K, Yamamoto H, Takamaru H, Yamamoto E, Maruyama R, Nobuoka T, Miyazaki Y, Nishida T, Bamba T, Kanda T, Ajioka Y, Taguchi T, Okahara S, Takahashi H, Nishida Y, Hosokawa M, Hasegawa T, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y
    Cancer research 72 1126-1136 2012年03月 [査読有り]
  • Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers.
    Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y
    Cancer science 103 252-261 2012年02月 [査読有り]
  • Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers.
    Baba Y, Nosho K, Shima K, Hayashi M, Meyerhardt JA, Chan AT, Giovannucci E, Fuchs CS, Ogino S
    Cancer 117 1399-1408 2011年04月 [査読有り]
  • Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer.
    Morikawa T, Kuchiba A, Yamauchi M, Meyerhardt JA, Shima K, Nosho K, Chan AT, Giovannucci E, Fuchs CS, Ogino S
    JAMA 305 1685-1694 2011年04月 [査読有り]
  • Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review.
    Shima K, Nosho K, Baba Y, Cantor M, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S
    International journal of cancer. Journal international du cancer 128 1080-1094 2011年03月 [査読有り]
  • STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers.
    Morikawa T, Baba Y, Yamauchi M, Kuchiba A, Nosho K, Shima K, Tanaka N, Huttenhower C, Frank DA, Fuchs CS, Ogino S
    Clinical cancer research : an official journal of the American Association for Cancer Research 17 1452-1462 2011年03月 [査読有り]
  • MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers.
    Shima K, Morikawa T, Baba Y, Nosho K, Suzuki M, Yamauchi M, Hayashi M, Giovannucci E, Fuchs CS, Ogino S
    Cancer causes & control : CCC 22 301-309 2011年02月 [査読有り]
  • Hypomethylation of the IGF2 DMR in colorectal tumors, detected by bisulfite pyrosequencing, is associated with poor prognosis.
    Baba Y, Nosho K, Shima K, Huttenhower C, Tanaka N, Hazra A, Giovannucci EL, Fuchs CS, Ogino S
    Gastroenterology 139 1855-1864 2010年12月 [査読有り]
  • Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review.
    Nosho K, Baba Y, Tanaka N, Shima K, Hayashi M, Meyerhardt JA, Giovannucci E, Dranoff G, Fuchs CS, Ogino S
    The Journal of pathology 222 350-366 2010年12月 [査読有り]
  • Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer.
    Tanaka N, Huttenhower C, Nosho K, Baba Y, Shima K, Quackenbush J, Haigis KM, Giovannucci E, Fuchs CS, Ogino S
    The American journal of pathology 177 2731-2740 2010年12月 [査読有り]
  • Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia.
    Chan AT, Baba Y, Shima K, Nosho K, Chung DC, Hung KE, Mahmood U, Madden K, Poss K, Ranieri A, Shue D, Kucherlapati R, Fuchs CS, Ogino S
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 19 2777-2785 2010年11月 [査読有り]
  • NRAS mutations are rare in colorectal cancer.
    Irahara N, Baba Y, Nosho K, Shima K, Yan L, Dias-Santagata D, Iafrate AJ, Fuchs CS, Haigis KM, Ogino S
    Diagnostic molecular pathology : the American journal of surgical pathology, part B 19 157-163 2010年09月 [査読有り]
  • CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival.
    Firestein R, Shima K, Nosho K, Irahara N, Baba Y, Bojarski E, Giovannucci EL, Hahn WC, Fuchs CS, Ogino S
    International journal of cancer. Journal international du cancer 126 2863-2873 2010年06月 [査読有り]
  • HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers.
    Baba Y, Nosho K, Shima K, Irahara N, Chan AT, Meyerhardt JA, Chung DC, Giovannucci EL, Fuchs CS, Ogino S
    The American journal of pathology 176 2292-2301 2010年05月 [査読有り]
  • Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors.
    Baba Y, Huttenhower C, Nosho K, Tanaka N, Shima K, Hazra A, Schernhammer ES, Hunter DJ, Giovannucci EL, Fuchs CS, Ogino S
    Molecular cancer 9 125 2010年05月 [査読有り]
  • Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells.
    Irahara N, Nosho K, Baba Y, Shima K, Lindeman NI, Hazra A, Schernhammer ES, Hunter DJ, Fuchs CS, Ogino S
    The Journal of molecular diagnostics : JMD 12 177-183 2010年03月 [査読有り]
  • PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
    Baba Y, Nosho K, Shima K, Goessling W, Chan AT, Ng K, Chan JA, Giovannucci EL, Fuchs CS, Ogino S
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 19 822-831 2010年03月 [査読有り]
  • Negative lymph node count is associated with survival of colorectal cancer patients, independent of tumoral molecular alterations and lymphocytic reaction.
    Ogino S, Nosho K, Irahara N, Shima K, Baba Y, Kirkner GJ, Mino-Kenudson M, Giovannucci EL, Meyerhardt JA, Fuchs CS
    The American journal of gastroenterology 105 420-433 2010年02月 [査読有り]
  • A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers.
    Nosho K, Kure S, Irahara N, Shima K, Baba Y, Spiegelman D, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S
    Gastroenterology 137 1609-20.e1 2009年11月 [査読有り]
  • Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen.
    Yamaoka S, Yamamoto H, Nosho K, Taniguchi H, Adachi Y, Sasaki S, Arimura Y, Imai K, Shinomura Y
    World journal of gastroenterology : WJG 15 5579-5585 2009年11月 [査読有り]
  • Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer.
    Kure S, Nosho K, Baba Y, Irahara N, Shima K, Ng K, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 18 2765-2772 2009年10月 [査読有り]
  • Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype.
    Ogino S, Nosho K, Irahara N, Meyerhardt JA, Baba Y, Shima K, Glickman JN, Ferrone CR, Mino-Kenudson M, Tanaka N, Dranoff G, Giovannucci EL, Fuchs CS
    Clinical cancer research : an official journal of the American Association for Cancer Research 15 6412-6420 2009年10月 [査読有り]
  • Prognostic significance and molecular associations of 18q loss of heterozygosity: a cohort study of microsatellite stable colorectal cancers.
    Ogino S, Nosho K, Irahara N, Shima K, Baba Y, Kirkner GJ, Meyerhardt JA, Fuchs CS
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27 4591-4598 2009年09月 [査読有り]
  • Interaction of molecular markers and physical activity on mortality in patients with colon cancer.
    Meyerhardt JA, Ogino S, Kirkner GJ, Chan AT, Wolpin B, Ng K, Nosho K, Shima K, Giovannucci EL, Loda M, Fuchs CS
    Clinical cancer research : an official journal of the American Association for Cancer Research 15 5931-5936 2009年09月 [査読有り]
  • p21 expression in colon cancer and modifying effects of patient age and body mass index on prognosis.
    Ogino S, Nosho K, Shima K, Baba Y, Irahara N, Kirkner GJ, Hazra A, De Vivo I, Giovannucci EL, Meyerhardt JA, Fuchs CS
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 18 2513-2521 2009年09月 [査読有り]
  • A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis.
    Ogino S, Nosho K, Baba Y, Kure S, Shima K, Irahara N, Toyoda S, Chen L, Kirkner GJ, Wolpin BM, Chan AT, Giovannucci EL, Fuchs CS
    The American journal of gastroenterology 104 2047-2056 2009年08月 [査読有り]
  • SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
    Nosho K, Shima K, Irahara N, Kure S, Firestein R, Baba Y, Toyoda S, Chen L, Hazra A, Giovannucci EL, Fuchs CS, Ogino S
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 22 922-932 2009年07月 [査読有り]
  • A cohort study of cyclin D1 expression and prognosis in 602 colon cancer cases.
    Ogino S, Nosho K, Irahara N, Kure S, Shima K, Baba Y, Toyoda S, Chen L, Giovannucci EL, Meyerhardt JA, Fuchs CS
    Clinical cancer research : an official journal of the American Association for Cancer Research 15 4431-4438 2009年07月 [査読有り]
  • Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer.
    Baba Y, Nosho K, Shima K, Freed E, Irahara N, Philips J, Meyerhardt JA, Hornick JL, Shivdasani RA, Fuchs CS, Ogino S
    Clinical cancer research : an official journal of the American Association for Cancer Research 15 4665-4673 2009年07月 [査読有り]
  • DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
    Nosho K, Shima K, Irahara N, Kure S, Baba Y, Kirkner GJ, Chen L, Gokhale S, Hazra A, Spiegelman D, Giovannucci EL, Jaenisch R, Fuchs CS, Ogino S
    Clinical cancer research : an official journal of the American Association for Cancer Research 15 3663-3671 2009年06月 [査読有り]
  • A cohort study of p27 localization in colon cancer, body mass index, and patient survival.
    Ogino S, Shima K, Nosho K, Irahara N, Baba Y, Wolpin BM, Giovannucci EL, Meyerhardt JA, Fuchs CS
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 18 1849-1858 2009年06月 [査読有り]
  • Aurora-A expression is independently associated with chromosomal instability in colorectal cancer.
    Baba Y, Nosho K, Shima K, Irahara N, Kure S, Toyoda S, Kirkner GJ, Goel A, Fuchs CS, Ogino S
    Neoplasia (New York, N.Y.) 11 418-425 2009年05月 [査読有り]
  • Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis.
    Ogino S, Shima K, Baba Y, Nosho K, Irahara N, Kure S, Chen L, Toyoda S, Kirkner GJ, Wang YL, Giovannucci EL, Fuchs CS
    Gastroenterology 136 1242-1250 2009年04月 [査読有り]
  • PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.
    Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, Fuchs CS
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27 1477-1484 2009年03月 [査読有り]
  • CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer.
    Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Meyerhardt JA, Loda M, Giovannucci EL, Fuchs CS
    Gut 58 90-96 2009年01月 [査読有り]
  • JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype.
    Nosho K, Shima K, Kure S, Irahara N, Baba Y, Chen L, Kirkner GJ, Fuchs CS, Ogino S
    Neoplasia (New York, N.Y.) 11 87-95 2009年01月 [査読有り]
  • Cohort study of fatty acid synthase expression and patient survival in colon cancer.
    Ogino S, Nosho K, Meyerhardt JA, Kirkner GJ, Chan AT, Kawasaki T, Giovannucci EL, Loda M, Fuchs CS
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology 26 5713-5720 2008年12月 [査読有り]
  • A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer.
    Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Chan AT, Schernhammer ES, Giovannucci EL, Fuchs CS
    Journal of the National Cancer Institute 100 1734-1738 2008年12月 [査読有り]
  • Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer.
    Ogino S, Kirkner GJ, Nosho K, Irahara N, Kure S, Shima K, Hazra A, Chan AT, Dehari R, Giovannucci EL, Fuchs CS
    Clinical cancer research : an official journal of the American Association for Cancer Research 14 8221-8227 2008年12月 [査読有り]
  • LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
    Ogino S, Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS
    International journal of cancer. Journal international du cancer 122 2767-2773 2008年06月 [査読有り]
  • PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations.
    Nosho K, Kawasaki T, Ohnishi M, Suemoto Y, Kirkner GJ, Zepf D, Yan L, Longtine JA, Fuchs CS, Ogino S
    Neoplasia (New York, N.Y.) 10 534-541 2008年06月 [査読有り]
  • Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma.
    Nosho K, Yamamoto H, Takahashi T, Mikami M, Hizaki K, Maehata T, Taniguchi H, Yamaoka S, Adachi Y, Itoh F, Imai K, Shinomura Y
    Human pathology 39 767-775 2008年05月 [査読有り]
  • Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer.
    Maehata T, Taniguchi H, Yamamoto H, Nosho K, Adachi Y, Miyamoto N, Miyamoto C, Akutsu N, Yamaoka S, Itoh F
    World journal of gastroenterology : WJG 14 2702-2714 2008年05月 [査読有り]
  • CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci.
    Kawasaki T, Ohnishi M, Nosho K, Suemoto Y, Kirkner GJ, Meyerhardt JA, Fuchs CS, Ogino S
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 21 245-255 2008年03月 [査読有り]
  • Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma.
    Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Glickman JN, Chan AT, Kirkner GJ, Mino-Kenudson M, Fuchs CS, Ogino S
    BMC cancer 8 33 2008年01月 [査読有り]
  • Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.
    Nosho K, Irahara N, Shima K, Kure S, Kirkner GJ, Schernhammer ES, Hazra A, Hunter DJ, Quackenbush J, Spiegelman D, Giovannucci EL, Fuchs CS, Ogino S
    PloS one 3 e3698 2008年 [査読有り]
  • IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53.
    Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS, Ogino S
    Neoplasia (New York, N.Y.) 9 1091-1098 2007年12月 [査読有り]
  • MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer.
    Ogino S, Hazra A, Tranah GJ, Kirkner GJ, Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Meyerhardt JA, Hunter DJ, Fuchs CS
    Carcinogenesis 28 1985-1990 2007年09月 [査読有り]
  • Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer.
    Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Dehari R, Meyerhardt JA, Fuchs CS, Ogino S
    Neoplasia (New York, N.Y.) 9 569-577 2007年07月 [査読有り]
  • A case of multiple protruding and flat colorectal tumors analyzed by a cDNA array.
    Nosho K, Yamamoto H, Hamamoto Y, Goto A, Yoshida Y, Arimura Y, Endo T, Imai K
    International journal of colorectal disease 22 723-724 2007年06月 [査読有り]
  • Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers.
    Nosho K, Yamamoto H, Takahashi T, Mikami M, Taniguchi H, Miyamoto N, Adachi Y, Arimura Y, Itoh F, Imai K, Shinomura Y
    Carcinogenesis 28 1364-1370 2007年06月 [査読有り]
  • Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma.
    Imsumran A, Adachi Y, Yamamoto H, Li R, Wang Y, Min Y, Piao W, Nosho K, Arimura Y, Shinomura Y, Hosokawa M, Lee CT, Carbone DP, Imai K
    Carcinogenesis 28 947-956 2007年05月 [査読有り]
  • Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas.
    Takahashi T, Nosho K, Yamamoto H, Mikami M, Taniguchi H, Miyamoto N, Adachi Y, Itoh F, Imai K, Shinomura Y
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20 139-147 2007年01月 [査読有り]
  • Mutational analysis of beta-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours.
    Mikami M, Nosho K, Yamamoto H, Takahashi T, Maehata T, Taniguchi H, Adachi Y, Imamura A, Fujita M, Hosokawa M, Itoh F, Imai K, Shinomura Y
    European journal of cancer (Oxford, England : 1990) 42 3065-3072 2006年11月 [査読有り]
  • Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis.
    Nosho K, Yamamoto H, Mikami M, Taniguchi H, Takahashi T, Adachi Y, Imamura A, Imai K, Shinomura Y
    European journal of cancer (Oxford, England : 1990) 42 2374-2381 2006年09月 [査読有り]
  • Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.
    Taniguchi H, Yamamoto H, Hirata T, Miyamoto N, Oki M, Nosho K, Adachi Y, Endo T, Imai K, Shinomura Y
    Oncogene 24 7946-7952 2005年11月 [査読有り]
  • A case of pneumatosis cystoides intestinalis with dermatomyositis in which EUS was useful for the diagnosis.
    Nosho K, Hatakeyama K, Hamamoto Y, Goto A, Yamamoto H, Yoshida Y, Arimura Y, Endo T, Hinoda Y, Imai K
    International journal of colorectal disease 20 473-474 2005年09月 [査読有り]
  • Diaphragm disease of small intestine diagnosed by double-balloon enteroscopy.
    Nosho K, Endo T, Yoda Y, Yoshida M, Goto A, Yamashita K, Yamamoto H, Yoshida Y, Arimura Y, Hirata K, Imai K
    Gastrointestinal endoscopy 62 187-189 2005年07月 [査読有り]
  • A case of ulcerative colitis in which colitic cancer was predictable by a cDNA array analysis.
    Nosho K, Yamamoto H, Maruyama R, Goto A, Imai K
    The American journal of medicine 118 688-689 2005年06月 [査読有り]
  • A case of colorectal carcinoma in adenoma analyzed by a cDNA array.
    Nosho K, Yamamoto H, Takamaru H, Hamamoto Y, Goto A, Yoshida Y, Arimura Y, Endo T, Hirata K, Imai K
    International journal of colorectal disease 20 287-291 2005年05月 [査読有り]
  • Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis.
    Nosho K, Yoshida M, Yamamoto H, Taniguchi H, Adachi Y, Mikami M, Hinoda Y, Imai K
    Carcinogenesis 26 892-899 2005年05月 [査読有り]
  • Gigantic gastrointestinal stromal tumor in the pelvis.
    Adachi Y, Yamamoto H, Nosho K, Tanimura A, Yuasa H, Ishi Y, Imai K, Kato Y
    International journal of colorectal disease 20 196-198 2005年03月 [査読有り]
  • Genetic analysis of advanced colon cancer of 8 mm with liver metastasis.
    Nosho K, Yamamoto H, Suzuki C, Niinuma T, Satoh A, Yoshida M, Nakahara S, Goto A, Yamashita K, Yoshida Y, Adachi Y, Arimura Y, Endo T, Hirata K, Imai K
    International journal of colorectal disease 20 81-82 2005年01月 [査読有り]
  • Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma.
    Yamamoto H, Vinitketkumnuen A, Adachi Y, Taniguchi H, Hirata T, Miyamoto N, Nosho K, Imsumran A, Fujita M, Hosokawa M, Hinoda Y, Imai K
    Carcinogenesis 25 2353-2360 2004年12月 [査読有り]
  • Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis.
    Nosho K, Yamamoto H, Taniguchi H, Adachi Y, Yoshida Y, Arimura Y, Endo T, Hinoda Y, Imai K
    Clinical cancer research : an official journal of the American Association for Cancer Research 10 7950-7957 2004年12月 [査読有り]
  • Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer.
    Yamamoto H, Horiuchi S, Adachi Y, Taniguchi H, Nosho K, Min Y, Imai K
    Carcinogenesis 25 325-332 2004年03月 [査読有り]
  • Usefulness of narrow-band imaging endoscopy for diagnosis of Barrett's esophagus.
    Hamamoto Y, Endo T, Nosho K, Arimura Y, Sato M, Imai K
    Journal of gastroenterology 39 14-20 2004年01月 [査読有り]
  • [Expression of trypsin and cancer proliferation in colorectal neoplasms].
    Yamamoto H, Nosho K, Taniguchi H, Imai K
    Nihon rinsho. Japanese journal of clinical medicine 61 Suppl 7 220-224 2003年09月 [査読有り]
  • Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer.
    Yamamoto H, Iku S, Adachi Y, Imsumran A, Taniguchi H, Nosho K, Min Y, Horiuchi S, Yoshida M, Itoh F, Imai K
    The Journal of pathology 199 176-184 2003年02月 [査読有り]

MISC

  • miR-196aとHOTAIRの高発現は消化管間質腫瘍の悪性化に関与する
    新沼 猛, 鈴木 拓, 野島 正寛, 能正 勝彦, 山本 博幸, 高丸 博幸, 山本 英一郎, 丸山 玲緒, 信岡 隆幸, 宮嵜 安晃, 西田 俊朗, 番場 竹生, 神田 達夫, 味岡 洋一, 田口 尚弘, 岡原 聡, 高橋 宏明, 西田 靖仙, 細川 正夫, 長谷川 匡, 時野 隆至, 平田 公一, 今井 浩三, 豊田 実, 篠村 恭久
    北海道醫學雜誌 = Acta medica Hokkaidonensia 87(6) 2012年11月
  • 食事成分と癌の浸潤・転移への影響
    山本 博幸, 能正 勝彦, 須河 恭敬, 國本 浩明, 五十嵐 央祥, 住岡 幼菜, 中澤 眞由美, 佐々木 茂, 足立 靖, 篠村 恭久
    消化と吸収 34(4) 410-415 2012年04月
  • 胃粘膜にAAアミロイドの沈着を伴った全身性エリテマトーデスと強皮症の重複症候群の1症例
    小畑 俊郎, 高橋 裕樹, 能正 勝彦, 池田 幸穂, 得能 徹也, 川人 由美子, 本多 佐保, 牧口 祐介, 今井 浩三, 池田 健
    リウマチ 38(6) 810-817 1999年01月
  • シクロホスファミドパルス療法が有効であった蛋白漏出性胃腸症合併混合性結合組織病の1症例
    能正 勝彦, 高橋 裕樹, 池田 幸穂, 花井 幸恵, 水越 常徳, 村上 理絵子, 得能 徹也, 川人 由美子, 牧口 祐介, 今井 浩三, 猪俣 慎一郎, 斉藤 司, 池田 健
    リウマチ 38(6) 818-824 1999年01月
  • 腹腔内腫瘍で発症し,化学療法に抵抗性を示したCD7陽性幹細胞性リンパ腫
    高橋 徹, 花井 幸恵, 能正 勝彦, 相馬 智彦, 株本 貴史, 西村 進, 林 敏昭, 安達 正晃, 日野田 裕治, 今井 浩三
    臨床血液 39(12) 1185-1189 1998年12月
MISCを全て表示する
  • miR-196aとHOTAIRの高発現は消化管間質腫瘍の悪性化に関与する
    新沼 猛, 鈴木 拓, 野島 正寛, 能正 勝彦, 山本 博幸, 高丸 博幸, 山本 英一郎, 丸山 玲緒, 信岡 隆幸, 宮嵜 安晃, 西田 俊朗, 番場 竹生, 神田 達夫, 味岡 洋一, 田口 尚弘, 岡原 聡, 高橋 宏明, 西田 靖仙, 細川 正夫, 長谷川 匡, 時野 隆至, 平田 公一, 今井 浩三, 豊田 実, 篠村 恭久
    北海道醫學雜誌 = Acta medica Hokkaidonensia 87(6) 2012年11月
  • 食事成分と癌の浸潤・転移への影響
    山本 博幸, 能正 勝彦, 須河 恭敬, 國本 浩明, 五十嵐 央祥, 住岡 幼菜, 中澤 眞由美, 佐々木 茂, 足立 靖, 篠村 恭久
    消化と吸収 34(4) 410-415 2012年04月
  • 胃粘膜にAAアミロイドの沈着を伴った全身性エリテマトーデスと強皮症の重複症候群の1症例
    小畑 俊郎, 高橋 裕樹, 能正 勝彦, 池田 幸穂, 得能 徹也, 川人 由美子, 本多 佐保, 牧口 祐介, 今井 浩三, 池田 健
    リウマチ 38(6) 810-817 1999年01月
  • シクロホスファミドパルス療法が有効であった蛋白漏出性胃腸症合併混合性結合組織病の1症例
    能正 勝彦, 高橋 裕樹, 池田 幸穂, 花井 幸恵, 水越 常徳, 村上 理絵子, 得能 徹也, 川人 由美子, 牧口 祐介, 今井 浩三, 猪俣 慎一郎, 斉藤 司, 池田 健
    リウマチ 38(6) 818-824 1999年01月
  • 腹腔内腫瘍で発症し,化学療法に抵抗性を示したCD7陽性幹細胞性リンパ腫
    高橋 徹, 花井 幸恵, 能正 勝彦, 相馬 智彦, 株本 貴史, 西村 進, 林 敏昭, 安達 正晃, 日野田 裕治, 今井 浩三
    臨床血液 39(12) 1185-1189 1998年12月


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