2025/08/22 更新

写真a

コバヤシ　ノブミチ
小林　宣道
所属
医学部 社会医学講座衛生学分野 教授
職名
教授
外部リンク

学位

  • 博士（医学）

研究キーワード

  • 衛生学

  • ウイルス学

  • 細菌学

研究分野

  • ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含む

学歴

  • 札幌医科大学

    - 1986年

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  • 札幌医科大学

    - 1986年

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    国名： 日本国

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所属学協会

論文

  • Isolation of <i>vanA</i>-Mediated Vancomycin-Resistant <i>Enterococcus faecalis</i> (ST1912/CC116) and <i>Enterococcus faecium</i> (ST80/CC17), <i>optrA</i>-Positive Linezolid-Resistant <i>E. faecalis</i> (ST32, ST1902) from Human Clinical Specimens in Bangladesh

    Sangjukta Roy, Meiji Soe Aung, Shyamal Kumar Paul, Md. Nazmul Alam Khan, Syeda Anjuman Nasreen, Muhammad Saiful Hasan, Nazia Haque, Tridip Kanti Barman, Jobyda Khanam, Fardousi akter sathi, Shashwata Paul, Mohammad Ibrahim Ali, Nobumichi Kobayashi

    Antibiotics   2025年3月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/antibiotics14030261

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  • Epidemiological Features of Leptospirosis and Identification of <i>Leptospira wolffii</i> as a Persistently Prevailing Species in North–Central Bangladesh

    Monira Sultana, Shyamal Kumar Paul, Syeda Anjuman Nasreen, Nazia Haque, Md. Kamrul Hasan, Arup Islam, Sultana Shabnam Nila, Afsana Jahan, Fardousi akter sathi, Tasmia Hossain, Syeda Jannatul Ferdaus, Meiji Soe Aung, Nobumichi Kobayashi

    Infectious Disease Reports   2024年7月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/idr16040049

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  • The Prevalence, Risk Factors, and Antimicrobial Resistance Determinants of <i>Helicobacter pylori</i> Detected in Dyspeptic Patients in North–Central Bangladesh

    Syeda Jannatul Ferdaus Syeda Jannatul ferdaus, Shyamal Kumar Paul, Syeda Anjuman Nasreen, Nazia Haque, Mohammad Sadekuzzaman, Mohammad Reazul Karim, Syed Mahmudul Islam, Abdullah Al Mamun, Fardousi akter sathi, Proma Basak, Rifat Binte Nahid, Suraiya Aktar, Nobumichi Kobayashi

    Infectious Disease Reports   2024年2月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/idr16020014

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  • Molecular Epidemiological Characterization of Methicillin-Resistant Staphylococcus aureus from Bloodstream Infections in Northern Japan: Increasing Trend of CC1 and Identification of ST8-SCCmec IVa USA300-Like Isolate Lacking Arginine Catabolic Mobile Element. 国際誌

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Mina Hirose, Yuuki Kimura, Kenji Kudo, Masahiko Ito, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   2023年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Methicillin-resistant Staphylococcus aureus (MRSA) is a major infectious disease pathogen, and its molecular epidemiological profile has been changing. In this study, a total of 279 MRSA isolates were collected from patients with bloodstream infection (BSI) in Hokkaido, northern main island of Japan, for a 2-year period from August 2019 to July 2021. CC5 (ST5/ST764)-MRSA-IIa (SCCmec-IIa) (47%, n = 132) and CC1 (ST1/ST2725/ST2764)-MRSA-IVa (42%, n = 116) were found to be major lineages, with CC8-MRSA-IVa being lower prevalence (5%, n = 13). CC1-MRSA-IVa showed a relatively increased proportion compared with our previous study (22%, 2017-2019). Seven isolates with SCCmec IVa (2.5%) were positive for Panton-Valentine leukocidin genes on ΦSa2usa and belonged to ST8/spa-t008/agr-I/coa-IIIa, showing genetic features of the USA300 clone. Among these isolates, six isolates harbored arginine catabolic mobile element (ACME) type I typical to the USA300 clone, while it was not detected in an isolate (strain R3-8). Whole genomic analysis of strain R3-8 revealed that its chromosome was highly similar to the USA300 strain TCH1516, but lacked ACME, carrying a plasmid genetically close to that of USA300 strains. The present study revealed increasing trend of CC1-MRSA-IV and occurrence of a novel variant of the USA300 clone among MRSA from BSI in northern Japan.

    DOI： 10.1089/mdr.2023.0203

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  • Prevalence, clonal diversity, and antimicrobial resistance of hypervirulent Klebsiella pneumoniae and Klebsiella variicola clinical isolates in northern Japan. 国際誌

    Norifumi Matsuda, Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Kenji Taniguchi, Kenji Kudo, Masahiko Ito, Nobumichi Kobayashi

    Journal of global antimicrobial resistance   35   11 - 18   2023年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    OBJECTIVES: Hypervirulent Klebsiella pneumoniae (hvKp) and Klebsiella variicola (hvKv) cause hospital/community-acquired infections, often associated with antimicrobial resistance (AMR). This study aimed to investigate the molecular epidemiology of hvKp and hvKv in northern Japan. METHODS: A total of 500 K. pneumoniae and 421 K. variicola clinical isolates collected from August to December 2021 were studied. Prevalence of virulence factor-encoding genes, wzi sequence and associated K/KL type, sequence type (ST), and beta-lactamases and their types were characterized. RESULTS: Any virulence gene (rmpA, rmpA2, peg-344, iucA, iutA, and iroB) and/or magA was detected in 25% (n = 125) of K. pneumoniae and 1% (n = 5) of K. variicola. Among these hvKp/hvKv, 22 wzi types (18 and 4 types, respectively) and 24 STs (20 and 4 STs, respectively) were identified. Sequence types of hvKp were classified into some clonal groups (CGs), among which CG35, including six STs, was the most common (n = 59; 47%), followed by CG23, and CG65. ST268 (CG35) associated with wzi95-K20 or wzi720 was the dominant lineage (n = 43, 34%), while K1:ST23/ST249 and K2:ST65/ST86 accounted for 26% and 13% of hvKp, respectively. Extended-spectrum beta-lactamase (ESBL) genes (blaCTX-M-2, blaCTX-M-3, blaCTX-M-15, and blaCTX-M-27) were detected in only ST23 and CG35 (ST268 and ST412) hvKp. No isolate was resistant to carbapenems, without detection of the ESBL gene in K. variicola. Phylogenetically, wzi was differentiated into two main clusters of K. pneumoniae and K. variicola. A major clonal group CG347 was identified in K. variicola. CONCLUSION: Clonal structures were revealed for hvKp and hvKv clinical isolates with their AMR status in northern Japan.

    DOI： 10.1016/j.jgar.2023.08.009

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  • Spread of multidrug resistance in non-PCV13/PCV20 serotypes of Streptococcus pneumoniae: A cross-sectional study ten years after the introduction of pneumococcal conjugate vaccine in Japan. 国際誌

    Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Nobuhide Ohashi, Rika Takamatsu, Sho Tsutida, Masahiko Ito, Nobumichi Kobayashi

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi   56 ( 6 )   1288 - 1292   2023年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Ten years after the introduction of the pneumococcal conjugate vaccine (PCV) in Japan, the prevalence rates of non-PCV13 and non-PCV20 serotypes among pediatric pneumococcal isolates were 94.0% and 73.7%, respectively. The predominant non-PCV13/PCV20 serotypes (15A, 35B, and 23A) were mostly multidrug-resistant (≥80.5%), exhibiting non-susceptibility to penicillin.

    DOI： 10.1016/j.jmii.2023.07.004

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  • Prevalence, clonal diversity, and antimicrobial resistance of hypervirulent Klebsiella pneumoniae and Klebsiella variicola clinical isolates in northern Japan

    Norifumi Matsuda, Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Kenji Taniguchi, Kenji Kudo, Masahiko Ito, Nobumichi Kobayashi

    Journal of Global Antimicrobial Resistance   35   11 - 18   2023年12月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.jgar.2023.08.009

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  • Genome analysis of an SCCmec element in ST9-MRSA from Myanmar with a unique mec gene complex and two ccr gene complexes (ccrA1B1 and ccrA5B7). 国際誌

    Noriko Urushibara, Meiji Soe Aung, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Nobumichi Kobayashi

    The Journal of antimicrobial chemotherapy   78 ( 7 )   1805 - 1806   2023年7月

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    記述言語：英語  

    DOI： 10.1093/jac/dkad146

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  • Genome analysis of an SCCmec element in ST9-MRSA from Myanmar with a unique mec gene complex and two ccr gene complexes (ccrA1B1 and ccrA5B7)

    Noriko Urushibara, Meiji Soe Aung, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Nobumichi Kobayashi

    Journal of Antimicrobial Chemotherapy   78 ( 7 )   1805 - 1806   2023年7月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/jac/dkad146

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  • Surveillance of Human Rotaviruses in Wuhan, China (2019–2022): Whole-Genome Analysis of Emerging DS-1-like G8P[8] Rotavirus

    Xuan Zhou, Yuanhong Wang, Nan Chen, Beibei Pang, Man-Qing Liu, cai kun, Nobumichi Kobayashi

    International Journal of Molecular Sciences   2023年7月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/ijms241512189

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  • Clonal Diversity of <i>Candida auris</i>, <i>Candida blankii</i>, and <i>Kodamaea ohmeri</i> Isolated from Septicemia and Otomycosis in Bangladesh as Determined by Multilocus Sequence Typing

    Fardousi akter sathi, Meiji Soe Aung, Shyamal Kumar Paul, Syeda Anjuman Nasreen, Nazia Haque, Sangjukta Roy, Salma Ahmed, Mohammad Monirul Alam, Shahed Khan, Mohammad Arif Rabbany, Joy Prokas Biswas, Nobumichi Kobayashi

    Journal of Fungi   2023年6月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/jof9060658

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  • Antimicrobial Resistance, Virulence Factors, and Genotypes of Enterococcus faecalis and Enterococcus faecium Clinical Isolates in Northern Japan: Identification of optrA in ST480 E. faecalis 国際誌

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Mina Hirose, Kenji Kudo, Naoyuki Tsukamoto, Masahiko Ito, Nobumichi Kobayashi

    Antibiotics   12 ( 1 )   108 - 108   2023年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MDPI AG  

    Enterococcus faecalis and E. faecium are the major pathogens causing community- and healthcare-associated infections, with an ability to acquire resistance to multiple antimicrobials. The present study was conducted to determine the prevalence of virulence factors, drug resistance and its genetic determinants, and clonal lineages of E. faecalis and E. faecium clinical isolates in northern Japan. A total of 480 (426 E. faecalis and 54 E. faecium) isolates collected over a four-month period were analyzed. Three virulence factors promoting bacterial colonization (asa1, efaA, and ace) were more prevalent among E. faecalis (46–59%) than E. faecium, while a similar prevalence of enterococcal surface protein gene (esp) was found in these species. Between E. faecalis and E. faecium, an evident difference was noted for resistance to erythromycin, gentamicin, and levofloxacin and its responsible resistance determinants. Oxazolidinone resistance gene optrA and phenicol exporter gene fexA were identified in an isolate of E. faecalis belonging to ST480 and revealed to be located on a cluster similar to those of isolates reported in other Asian countries. The E. faecalis isolates analyzed were differentiated into 12 STs, among which ST179 and ST16 of clonal complex (CC) 16 were the major lineage. Nearly all the E. faecium isolates were assigned into CC17, which consisted of 10 different sequence types (STs), including a dominant ST17 containing multidrug resistant isolates and ST78 with isolates harboring the hyaluronidase gene (hyl). The present study revealed the genetic profiles of E. faecalis and E. faecium clinical isolates, with the first identification of optrA in ST480 E. faecalis in Japan.

    DOI： 10.3390/antibiotics12010108

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  • Spread of multidrug resistance in non-PCV13/PCV20 serotypes of Streptococcus pneumoniae: A cross-sectional study ten years after the introduction of pneumococcal conjugate vaccine in Japan

    Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Nobuhide Ohashi, Rika Takamatsu, Sho Tsutida, Masahiko Ito, Nobumichi Kobayashi

    Journal of Microbiology, Immunology and Infection   2023年

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.jmii.2023.07.004

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  • Genetic Characterization of <i>Staphylococcus aureus</i>, <i>Staphylococcus argenteus</i>, and Coagulase-Negative Staphylococci Colonizing Oral Cavity and Hand of Healthy Adults in Northern Japan

    Mina Hirose, Meiji Soe Aung, Yusuke Fujita, Taisei Kato, Yukito Hirose, Shoko Yahata, Atsushi Fukuda, Masato Saitoh, Noriko Urushibara, Nobumichi Kobayashi

    Pathogens   2022年7月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/pathogens11080849

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  • Multicenter Study of Carbapenemase-Producing <i>Enterobacterales</i> in Havana, Cuba, 2016&ndash;2021

    Haiyang Yu, María Karla González Molina, Yenisel Carmona Cartaya, Marcia Hart Casares, Meiji Soe Aung, Nobumichi Kobayashi, Dianelys Quiñones Pérez

    Antibiotics   2022年4月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/antibiotics11040514

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  • Bacterial Species and Antimicrobial Resistance of Clinical Isolates from Pediatric Patients in Yangon, Myanmar, 2020

    Thida San, Meiji Soe Aung, Nilar San, Myat Myint Zu Aung, Win Lei Yi Mon, Thin Ei Thazin, Nobumichi Kobayashi

    Infectious Disease Reports   2022年1月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/idr14010004

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  • Prevalence and Antimicrobial Resistance of Staphylococcus aureus and Coagulase-Negative Staphylococcus/Mammaliicoccus from Retail Ground Meat: Identification of Broad Genetic Diversity in Fosfomycin Resistance Gene fosB 査読 国際誌

    Masako Osada, Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Mina Hirose, Nobumichi Kobayashi

    pathogens   11 ( 4 )   496 - 483   2022年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Staphylococcus is a major bacterial species that contaminates retail meat products. The objective of this study was to clarify the prevalence, antimicrobial resistance and genetic determinants of Staphylococcus/Mammaliicoccus species in retail ground meat in Japan. From a total of 146 retail ground meat samples (chicken, pork, mixed beef/pork) purchased during a 5-month period, 10 S. aureus and 112 isolates of coagulase-negative staphylococcus (CoNS)/Mammaliicoccus comprising 20 species were recovered. S. aureus isolates were classified into five genetic types, i.e., coa-IIa/ST5, coa-VIc/ST352 (CC97), coa-VIIb/ST398, coa-Xa/ST15, and coa-XIc/ST9, which were all related to those of livestock-associated clones. All the staphylococcal isolates were mecA-negative and mostly susceptible to all the antimicrobials tested, except for ampicillin among S. aureus (resistance proportion; 50%). Among CoNS, the fosfomycin resistance gene fosB was prevalent (30/112; 26.8%), primarily in S. capitis, S. warneri, and S. saprophyticus. Phylogenetic analysis of fosB revealed the presence of seven clusters, showing broad diversity with 65-81% identity among different clusters. In the CoNS isolates from ground meat samples, fosB was assigned into three clusters, and S. saprophyticus harbored the most divergent fosB with three genetic groups. These findings suggested the circulation of multiple fosB-carrying plasmids among some CoNS species.

    DOI： 10.3390/pathogens11040469

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  • Clonal diversity of Clostridium perfringens human clinical isolates with various toxin gene profiles based on multilocus sequence typing and alpha-toxin (PLC) typing 国際誌

    Meiji Soe Aung, Asami Matsuda, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Norifumi Matsuda, Mayumi Nakamura, Masahiko Ito, Satoshi Habadera, Akinori Matsumoto, Mina Hirose, Nobumichi Kobayashi

    Anaerobe   72   102473 - 102473   2021年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.anaerobe.2021.102473

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  • Antimicrobial Resistance and Molecular Epidemiological Characteristics of Methicillin-Resistant and Susceptible Staphylococcal Isolates from Oral Cavity of Dental Patients and Staff in Northern Japan

    Mina Hirose, Meiji Soe Aung, Atsushi Fukuda, Shoko Yahata, Yusuke Fujita, Masato Saitoh, Yukito Hirose, Noriko Urushibara, Nobumichi Kobayashi

    Antibiotics   2021年10月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/antibiotics10111316

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  • Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh

    Snigdha Rahman Titir, Shyamal Kumar Paul, Salma Ahmed, Nazia Haque, Syeda Anjuman Nasreen, Khondoker Shoaib Hossain, Fahim Uddin Ahmad, Sultana Shabnam Nila, Jobyda Khanam, Neaz Nowsher, Abu Mohammod Mayeenuddin Al Amin, Amdad Ullah Khan, Meiji Soe Aung, Nobumichi Kobayashi

    Tropical Medicine and Infectious Disease   2021年4月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/tropicalmed6020058

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  • Clonal lineages and antimicrobial resistance of nonencapsulated Streptococcus pneumoniae in the post-pneumococcal conjugate vaccine era in Japan. 国際誌

    Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Kenji Kudo, Masahiko Ito, Ayako Sumi, Nobumichi Kobayashi

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   2021年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    OBJECTIVES: The emergence and spread of nonencapsulated Streptococcus pneumoniae (NESp) is a public health concern in the post-pneumococcal conjugate vaccine era. We analyzed the prevalence, molecular characteristics, and antimicrobial resistance of NESp responsible for non-invasive infections in northern Japan. METHODS: Among 4463 S. pneumoniae isolates collected from non-invasive infection cases during four study periods between January 2011 and January 2019, NESp isolates were identified using molecular and phenotypical methods. NESp isolates were analyzed for antimicrobial susceptibility, genotype, and virulence-associated genes. RESULTS: A total of 71 NESp isolates were identified (1.6% of all the clinical isolates) and assigned to the null capsule clade (NCC)1 (pspK+) (94.4%) or NCC2 (aliC+/aliD+) (5.6%). Five dominant sequence types (STs) were ST7502 (23.9%), ST4845 (19.7%), ST16214 (11.3%), ST11379 (9.9%), and ST7786 (7.0%). These dominant STs and all seven novel STs were related to the sporadic NESp lineage ST1106 or PMEN clone Denmark14-ST230. High non-susceptibility rates of NESp were observed for trimethoprim-sulfamethoxazole, erythromycin, and tetracycline (>92.9%), and multidrug resistance was observed in 88.7% of the NESp isolates, including all the ST7502, ST4845, and ST11379 isolates. CONCLUSIONS: The present study revealed that the dominant clonal groups of NESp were associated with a high prevalence of non-susceptibility to antimicrobials in northern Japan.

    DOI： 10.1016/j.ijid.2021.02.109

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  • Characterization of Neonatal Infections by Gram-Negative Bacilli and Associated Risk Factors, Havana, Cuba

    Arlenis Oliva, Yenisel Carmona, Elizabeth de La C. López, Roberto Álvarez, Meiji Soe Aung, Nobumichi Kobayashi, Dianelys Quiñones

    Infectious Disease Reports   2021年3月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/idr13010025

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  • Distribution of Virulence Factors and Resistance Determinants in Three Genotypes of <i>Staphylococcus argenteus</i> Clinical Isolates in Japan

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Mina Hirose, Miyo Ike, Masahiko Ito, Nobumichi Kobayashi

    Pathogens   2021年2月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/pathogens10020163

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  • Surveillance of Human Rotavirus in Wuhan, China (2011–2019): Predominance of G9P[8] and Emergence of G12

    Xuan Zhou, Yuan-Hong Wang, Bei-Bei Pang, Nan Chen, Nobumichi Kobayashi

    Pathogens   2020年10月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/pathogens9100810

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  • Drug Resistance Determinants in Clinical Isolates of Enterococcus faecalis in Bangladesh: Identification of Oxazolidinone Resistance Gene optrA in ST59 and ST902 Lineages. 国際誌

    Sangjukta Roy, Meiji Soe Aung, Shyamal Kumar Paul, Salma Ahmed, Nazia Haque, Emily Rahman Khan, Tridip Kanti Barman, Arup Islam, Sahida Abedin, Chand Sultana, Anindita Paul, Muhammad Akram Hossain, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Nobumichi Kobayashi

    Microorganisms   8 ( 8 )   2020年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Enterococcus faecalis is one of the major causes of urinary tract infection, showing acquired resistance to various classes of antimicrobials. The objective of this study was to determine the prevalence of drug resistance and its genetic determinants for E. faecalis clinical isolates in north-central Bangladesh. Among a total of 210 E. faecalis isolates, isolated from urine, the resistance rates to erythromycin, levofloxacin, and gentamicin (high level) were 85.2, 45.7, and 11.4%, respectively, while no isolates were resistant to ampicillin, vancomycin and teicoplanin. The most prevalent resistance gene was erm(B) (97%), and any of the four genes encoding aminoglycoside modifying enzyme (AME) were detected in 99 isolates (47%). The AME gene aac(6')-Ie-aph(2")-Ia was detected in 46 isolates (21.9%) and was diverse in terms of IS256-flanking patterns, which were associated with resistance level to gentamicin. Tetracycline resistance was ascribable to tet(M) (61%) and tet(L) (38%), and mutations in the quinolone resistance-determining region of both GyrA and ParC were identified in 44% of isolates. Five isolates (2.4%) exhibited non-susceptibility to linezolide (MIC, 4 μg/mL), and harbored the oxazolidinone resistance gene optrA, which was located in a novel genetic cluster containing the phenicol exporter gene fexA. The optrA-positive isolates belonged to ST59, ST902, and ST917 (CC59), while common lineages of other multiple drug-resistant isolates were ST6, ST28, CC16, and CC116. The present study first revealed the prevalence of drug resistance determinants of E. faecalis and their genetic profiles in Bangladesh.

    DOI： 10.3390/microorganisms8081240

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  • High prevalence of antimicrobial resistance in non-vaccine serotypes of non-invasive/colonization isolates of Streptococcus pneumoniae: A cross-sectional study eight years after the licensure of conjugate vaccine in Japan. 国際誌

    Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Masahiko Ito, Ayana Takahashi, Satoshi Habadera, Nobumichi Kobayashi

    Journal of infection and public health   13 ( 8 )   1094 - 1100   2020年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Multidrug resistance (MDR) in non-vaccine serotypes (NVTs)-Streptococcus pneumoniae is a global public health concern after the widespread use of pneumococcal conjugate vaccines (PCVs). The present study aimed to analyze the prevalence of serotypes and antimicrobial susceptibilities of non-invasive/colonization isolates of S. pneumoniae eight years after the introduction of PCV in Japan. METHODS: A total of 545 non-invasive pneumococcal isolates (460 children, 85 adults) obtained from July 2018 to January 2019 were studied. All isolates were tested for susceptibility to ten antimicrobials and were characterized for serotypes, penicillin binding protein (PBP) genotypes, and macrolide resistance genes. RESULTS: Among children, 95.0% of isolates belonged to non-13-valent pneumococcal conjugate vaccine (PCV13) serotypes (NVTs), with 15A (15.0%) being dominant, followed by 35B (12.2%), 23A (11.1%), 15B (9.8%), and 15C (9.6%). In contrast, serotype 3 (18.8%) was the most prevalent in adults, while 15A, 10A, and 23A were also common. Serotypes covered by PCV13 and 23-valent pneumococcal polysaccharide vaccine (PPSV23) in all the adult isolates were 25.9% and 48.2%, respectively. High resistance rates were observed against erythromycin, tetracycline, and clindamycin (≥62.4% children, ≥58.8% adults). Penicillin-resistant and penicillin-intermediate isolates represented 2.2% and 33.8% of all isolates, respectively. Most isolates of the three dominant NVTs 15A, 35B, and 23A were non-susceptible to penicillin. Overall, multiple drug resistance (MDR) was detected in 69.0% of all isolates, including dominant NVTs 15A, 35B, 23A, 15B, and 15C. Among all the isolates, 81.8% harbored at least one altered PBP genes, and erm(B), mef(A/E) and both these genes were found in 68.2%, 23.3%, and 6.8%, respectively. High prevalence (>90%) of erm(B) was observed in serogroup 15, and serotypes 23A, 33F, and 12F. CONCLUSION: The present study revealed the high prevalence of NVTs 15 and 23A, and 35B showing MDR, suggesting their spread after introduction of routine PCV immunization.

    DOI： 10.1016/j.jiph.2020.04.012

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  • Prevalence and Genetic Diversity of Staphylococcal Enterotoxin (-Like) Genes <i>sey</i>, <i>selw</i>, <i>selx</i>, <i>selz</i>, <i>sel26</i> and <i>sel27</i> in Community-Acquired Methicillin-Resistant <i>Staphylococcus aureus</i>

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi

    Toxins   2020年5月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/toxins12050347

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  • Latitudes mediate the association between influenza activity and meteorological factors: A nationwide modelling analysis in 45 Japanese prefectures from 2000 to 2018

    Ka Chun Chong, Jingbo Liang, Katherine Min Jia, Nobumichi Kobayashi, Maggie Haitian Wang, Lai Wei, Steven Yuk Fai Lau, Ayako Sumi

    Science of the Total Environment   703   2020年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier B.V.  

    DOI： 10.1016/j.scitotenv.2019.134727

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  • Novel staphylococcal cassette chromosome mec (SCCmec) type XIV (5A) and a truncated SCCmec element in SCC composite islands carrying speG in ST5 MRSA in Japan. 国際誌

    Noriko Urushibara, Meiji Soe Aung, Mitsuyo Kawaguchiya, Nobumichi Kobayashi

    The Journal of antimicrobial chemotherapy   75 ( 1 )   46 - 50   2020年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Staphylococcal cassette chromosome mec (SCCmec) elements are highly diverse and have been classified into 13 types. The arginine catabolic mobile element (ACME) is an SCC-like element harbouring an arginine deiminase pathway gene cluster (ACME-arc). ACME type I (ACME I), additionally including a spermidine/spermine-N1-acetyltransferase gene (speG), is considered to have contributed to the rapid spread of the most successful MRSA clone, USA300. OBJECTIVES: To characterize the SCC composite islands (SCC-CIs) in ST5 MRSA positive for both ACME-arc and speG. METHODS: Three ST5 MRSA strains (SC640, SC792 and SC955) collected in Hokkaido, Japan were subjected to WGS and the SCC-CIs were determined. RESULTS: The SCC-CIs consisted of four (SC640 and SC792) or three (SC955) SCC/SCC-like elements and commonly harboured both an ACME type II' and an SCC encoding speG. These SCC-CIs appear to mimic ACME I in USA300, in that they are equipped with ACME-arc and speG. The SCC-CIs of SC640 and SC792 contained novel SCCmec/SCCmec-like elements at the 3' end, whereas SC955 contained SCCmec type V. The SCCmec of SC792 carried mec complex A and ccrC1, which was determined to be novel and designated as SCCmec type XIV (5A). SC640 harboured an SCCmec-like element derived from SCCmec type XIV. It lacked most of the downstream region of the mec complex, including the left chromosomal attachment site (SCCmec XIV Δkdp/DR-L), and lost its capability for chromosomal excision, suggesting that the mecA gene is immobilized on the chromosome. CONCLUSIONS: These findings provide evidence for increasing complexity of SCC-CIs.

    DOI： 10.1093/jac/dkz406

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  • Detection and Molecular Characterization of Picobirnaviruses (PBVs) in the Mongoose: Identification of a Novel PBV Using an Alternative Genetic Code

    Alyssa Kleymann, Anne AMJ Becker, Yashpal Singh Malik, Nobumichi Kobayashi, Souvik Ghosh

    Viruses   2020年1月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/v12010099

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  • High Prevalence of CTX-M Type Extended-Spectrum Beta-Lactamase Genes and Detection of NDM-1 Carbapenemase Gene in Extraintestinal Pathogenic <i>Escherichia coli</i> in Cuba

    Dianelys Quiñones, Meiji Soe Aung, Yenisel Carmona, María Karla González, Niurka Pereda, Mercedes Hidalgo, Mayrelis Rivero, Arnaldo Zayas, Rosa del Campo, Noriko Urushibara, Nobumichi Kobayashi

    Pathogens   2020年1月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/pathogens9010065

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  • Clonal Diversity and Genetic Characteristics of Methicillin-Resistant Staphylococcus aureus Isolates from a Tertiary Care Hospital in Japan. 国際誌

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Masaaki Shinagawa, Satoshi Takahashi, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   25 ( 8 )   1164 - 1175   2019年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Molecular epidemiological characteristics were investigated for 1,041 isolates of methicillin-resistant Staphylococcus aureus (MRSA) collected in a tertiary care hospital in northern Japan for a 4-year period (2011-2014). Genotypes (staphylococcal cassette chromosome mec [SCCmec], sequence type, spa, coa, etc.) and the presence of drug resistance/virulence factor genes in the isolates were analyzed by multiplex/uniplex PCR, and PCR-direct sequencing as needed. Among these MRSA, predominant SCCmec type was IIa (87.2%), followed by IV (10.1%) and V (1.2%). The SCCmec IIa-MRSA belonged to coagulase genotype (coa) IIa and ST5/ST764, which are known as major health care-associated-MRSA (HA-MRSA) in Japan (New York/Japan clone) and its variant. Panton-Valentine leucocidine (PVL) genes were detected in only five isolates (0.5%) with genotypes ST8-SCCmec IVa/spa-t008/coa-IIIa (USA300 clone), ST6-SCCmec IVb, and ST59-SCCmec V (Taiwanese clone). Arginine catabolic mobile element (ACME) type I and II' were identified in three and five isolates of ST8-SCCmec IVa and ST764-SCCmec IIa MRSA, respectively. PVL-/ACME- isolates were classified into various STs/clonal complexes (CCs), with CC1, CC5, CC8, CC89, and CC121 being common. It was notable that SCCmec IVl was the most common among SCCmec IV subtypes, and was carried by almost half of coa-IIIa isolates (47%, 34/72) without PVL genes, which represented the novel ST8 MRSA clone spreading in Japan (i.e., "ST8/CA-MRSA/J"). Uncommon MRSA clones in Japan, ST72-SCCmec IV (South Korean clone), ST398 livestock-associated clone, and ST20 bovine-associated MRSA, were identified. Furthermore, we isolated PVL-negative ST8-SCCmec I/coa-IIIa and ST81-SCCmec V/coa-VIIa MRSA, which were considered presumptive novel clones. The present study revealed the genetic diversity of HA-MRSA, including potentially emerging clones of putative different origins.

    DOI： 10.1089/mdr.2018.0468

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  • Molecular Epidemiological Characterization of Staphylococcus argenteus Clinical Isolates in Japan: Identification of Three Clones (ST1223, ST2198, and ST2550) and a Novel Staphylocoagulase Genotype XV. 国際誌

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Seika Takahashi, Miyo Ike, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi

    Microorganisms   7 ( 10 )   2019年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Staphylococcus argenteus, a novel emerging species within Staphylococcus aureus complex (SAC), has been increasingly reported worldwide. In this study, prevalence of S. argenteus among human clinical isolates, and their clonal diversity and genetic characteristics of virulence factors were investigated in Hokkaido, the northern main island of Japan. During a four-month period starting from March 2019, twenty-four S. argenteus and 4330 S. aureus isolates were recovered from clinical specimens (the ratio of S. argenteus to S. aureus :0.0055). Half of S. argenteus isolates (n = 12) belonged to MLST sequence type (ST) 2250 and its single-locus variant, with staphylocoagulase genotype (coa-) XId, while the remaining isolates were assigned to ST2198/coa-XIV (n = 6), and ST1223 with a novel coa-XV identified in this study (n = 6). All the isolates were mecA-negative, and susceptible to all the antimicrobials tested, except for an ST2198 isolate with blaZ and an ST2250 isolate with tet(L) showing resistance to ampicillin and tetracyclines, respectively. Common virulence factors in the S. argenteus isolates were staphylococcal enterotoxin (-like) genes sey, selz, sel26, and sel27 in ST2250, selx in ST2198, and enterotoxin gene cluster (egc-1: seg-sei-sem-sen-seo) in ST1223 isolates, in addition to hemolysin genes (hla, hlb, and hld) distributed universally. Elastin binding protein gene (ebpS) and MSCRAMM family adhesin SdrE gene (sdrE) detected in all the isolates showed high sequence identity among them (> 97%), while relatively lower identity to those of S. aureus (78-92%). Phylogenetically, ebpS, sdrE, selx, sey, selw, sel26, and sel27 of S. argenteus formed clusters distinct from those of S. aureus, unlike sec, selz, tst-1, and staphylokinase gene (sak). The present study revealed the prevalence of S. argenteus among clinical isolates, and presence of three distinct S. argenteus clones (ST2250; ST2198 and ST1223) harboring different virulence factors in northern Japan. ST2198 S. argenteus, a minor clone (strain BN75-like) that had been rarely reported, was first identified in Japan as human isolates.

    DOI： 10.3390/microorganisms7100389

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  • Prevalence of Various Vaccine Candidate Proteins in Clinical Isolates of Streptococcus pneumoniae: Characterization of the Novel Pht Fusion Proteins PhtA/B and PhtA/D. 国際誌

    Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Masaaki Shinagawa, Satoshi Takahashi, Nobumichi Kobayashi

    Pathogens (Basel, Switzerland)   8 ( 4 )   2019年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Pneumococcal proteins unrelated to serotypes are considered to be candidates of antigens in next-generation vaccines. In the present study, the prevalence of vaccine candidate protein genes, along with serotypes and antimicrobial resistance determinants, was investigated in a total of 57 isolates obtained from a tertiary care hospital in Japan. All of the pediatric isolates and 76.6% of the adult isolates did not belong to PCV13 (a 13-valent pneumococcal conjugate vaccine) serotypes, and 70.2% of all isolates showed multidrug resistance. All of the isolates had ply, pavA, nanA, and nanB, and high prevalence was noted for the pspA and pspC genes (96.5% and 78.9%, respectively). Detection rates for the pneumococcal histidine triad protein (Pht) genes phtA, phtB, phtD, and phtE were 49.1%, 26.3%, 61.4%, and 100%, respectively. Two fusion-type genes, phtA/B and phtA/D, were identified, with a prevalence of 36.9% and 14.0%, respectively. These fusion types showed 78.1-90.0% nucleotide sequence identity with phtA, phtB, and phtD. The most prevalent pht profile was phtA + phtD + phtE (26.3%), followed by phtA/B + phtE (19.3%) and phtA/B + phtD + phtE (17.5%), while pht profiles including phtD and/or phtA/phtD were found in 71.9% of isolates. The present study revealed the presence of two fusion types of Pht and their unexpectedly high prevalence. These fusion types, as well as PhtA and PhtB, contained sequences similar to the B cell epitopes that have been previously reported for PhtD.

    DOI： 10.3390/pathogens8040162

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  • Prevalence and Genetic Diversity of Toxin Genes in Clinical Isolates of Clostridium perfringens: Coexistence of Alpha-Toxin Variant and Binary Enterotoxin Genes (bec/cpile). 国際誌

    Asami Matsuda, Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Mayumi Nakamura, Yuka Horino, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi

    Toxins   11 ( 6 )   2019年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Clostridium perfringens (C. perfringens) is responsible for food-borne gastroenteritis and other infectious diseases, and toxins produced by this bacterium play a key role in pathogenesis. Although various toxins have been described for C. perfringens isolates from humans and animals, prevalence of individual toxins among clinical isolates has not yet been well explored. In the present study, a total of 798 C. perfringens clinical isolates were investigated for prevalence of eight toxin genes and their genetic diversity by PCR, nucleotide sequencing, and phylogenetic analysis. Besides the alpha-toxin gene (plc) present in all the isolates, the most common toxin gene was cpe (enterotoxin) (34.2%), followed by cpb2 (beta2 toxin) (1.4%), netB (NetB) (0.3%), and bec/cpile (binary enterotoxin BEC/CPILE) (0.1%), while beta-, epsilon-, and iota-toxin genes were not detected. Genetic analysis of toxin genes indicated a high level of conservation of plc, cpe, and netB. In contrast, cpb2 was revealed to be considerably divergent, containing at least two lineages. Alpha-toxin among 46 isolates was classified into ten sequence types, among which common types were distinct from those reported for avian isolates. A single isolate with bec/cpile harbored a plc variant containing an insertion of 834-bp sequence, suggesting its putative origin from chickens.

    DOI： 10.3390/toxins11060326

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  • Association Between Pneumococcal Surface Protein A Family and Genetic/Antimicrobial Resistance Traits of Non-Invasive Pneumococcal Isolates from Adults in Northern Japan. 国際誌

    Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Satoshi Habadera, Masahiko Ito, Kenji Kudo, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   25 ( 5 )   744 - 751   2019年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Pneumococcal isolates from adult patients in northern Japan in 2016 were subjected to molecular investigation related to pneumococcal surface protein A (PspA) and drug resistance determinants. Of the 51 isolates, serotype 3/ST180 was the most prevalent (17.6%), followed by 35B (ST2755/ST558) (11.8%) and 15A (ST63/ST7874/ST13068/ST13785) (9.8%). Coverage of serotypes by 13-valent conjugate vaccine and 23-valent polysaccharide vaccine was 27.5% and 49%, respectively. All the isolates expressed PspA family 1 or 2 (51% and 49%, respectively). Each serotype was associated with either of the PspA families (e.g., serotype 3, PspA family 1; serotypes 35B and 15A, PspA family 2). Multidrug resistance (MDR) was found in 84.3% of the isolates. Minimum of one altered penicillin-binding protein gene was detected in 82.4% of isolates, indicating 25.5% non-susceptibility to penicillin. Serotypes 15A and 35B were predominant and demonstrated MDR. An isolate of serotype 15A/ST13785 (single-locus variant of ST242) was resistant to fluoroquinolones associated with double mutation in the quinolone resistance-determining regions of gyrA and parC. The present study indicates the spread of MDR pneumococci represented by isolates of serotypes 3, 15A, and 35B, and prevalence of both PspA family 1 and 2 in isolates obtained from adult patients.

    DOI： 10.1089/mdr.2018.0267

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  • Time-series analysis of geographically specific monthly number of newly registered cases of active tuberculosis in Japan

    Ayako Sumi, Nobumichi Kobayashi

    PLoS ONE   14 ( 3 )   2019年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Public Library of Science  

    DOI： 10.1371/journal.pone.0213856

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  • Molecular Epidemiological Characterization of Methicillin-Susceptible and -Resistant Staphylococcus aureus Isolated from Skin and Soft Tissue Infections in Bangladesh. 国際誌

    Nazia Haque, Meiji Soe Aung, Shyamal Kumar Paul, Md Shafikul Bari, Salma Ahmed, Santana Rani Sarkar, Sangjukta Roy, Syeda Anjuman Nasreen, Muhammad Chand Mahmud, Muhammad Akram Hossain, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   25 ( 2 )   241 - 250   2019年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Genetic background and molecular characteristics of Staphylococcus aureus collected from patients with skin and soft tissue infections were studied in the North-Central region of Bangladesh from 2015 to 2016. Among 430 clinical isolates, methicillin-resistant S. aureus (MRSA) accounted for 31% having SCCmec type IV (73%) and V (14%), and belonged mostly to coagulase (coa) genotypes IIa, IIIa, IVb, and XIa, while dominant coa type in methicillin-susceptible S. aureus (MSSA) was IIIa, followed by Va, IIa, and VIa. Panton-Valentine Leukocidin genes (pvl) were detected at higher rate in MSSA (54%) than in MRSA (24%). Based on multilocus sequence typing, pvl-positive MRSA isolates were classified into clonal complex 88 (CC88) (ST88, ST2884, ST4345), CC6 (ST6, ST4350), and CC1 (ST1, ST772), while pvl-negative MRSA into CC5, CC22, CC80, CC121, and CC672. The pvl-negative ST80 MRSA isolates had SCCmec-IVa (agr-III/coa-XIc, etd/edinB-positive, fusB-negative), indicating that they belong to the novel CC80 clade related to the European community-acquired MRSA clone. Among MSSA, genotypes ST121/spa-t645/coa-Va and ST2884 (CC88)/spa-t2393/coa-IIIa were identified in both pvl-positive and negative isolates, and all the ST772 isolates harbored pvl. All the ST121 isolates had a variant of elastin-binding protein gene (ebpS-v) with internal 180-nucleotide deletion. The present study suggested that CC88 (ST88, ST2884) and ST772 are the putative dominant lineages of pvl-positive MRSA/MSSA, while novel CC80 clade is one of the main pvl-negative MRSA lineages distributed endemically in Bangladesh.

    DOI： 10.1089/mdr.2018.0123

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  • Molecular characterization of Staphylococcus argenteus in Myanmar: identification of novel genotypes/clusters in staphylocoagulase, protein A, alpha-haemolysin and other virulence factors. 国際誌

    Meiji Soe Aung, Thida San, Nilar San, Win Mar Oo, Phyoe May Ko, Khin Thet Thet, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Nobumichi Kobayashi

    Journal of medical microbiology   68 ( 1 )   95 - 104   2019年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: Staphylococcus argenteus is a novel emerging species of coagulase-positive staphylococcus that is genetically closely related to Staphylococcus aureus. To elucidate the molecular differences in the virulence factors (staphylocoagulase, protein A, alpha-haemolysin, enterotoxin-like toxin and staphylokinase) between these staphylococcal species, S. argenteus that had recently been isolated in Myanmar (five nasal isolates and four clinical isolates) were analysed. METHODOLOGY: The nucleotide sequences of the virulence factors were determined by PCR and direct sequencing, followed by phylogenetic analysis by mega6 and multiple alignment by clustalw using the published sequence data for S. aureus and S. argenteus. RESULTS: Six S. argenteus isolates belonged to MLST sequence type (ST) 2250, while others belonged to ST4625, ST2198 and ST2854. The novel staphylocoagulase (coa) genotype XIV and the novel coa-XI subtype (XId) were identified in an ST2198 isolate and all other isolates, respectively. Among the S. argenteus isolates, the protein A and alpha-haemolysin genes showed high sequence identity (96-98 % and >99 %, respectively), while lower identity was observed between S. argenteus and S. aureus (88-91 % and 86 %, respectively), with both species showing phylogenetically distinct clusters. Similar findings were found for the staphylococcal enterotoxin (SE)-like toxin genes selw, selx and sely. In contrast, the staphylokinase genes were almost identical between these two species. All of the coa-XId isolates had a CRISPR/Cas locus at the site of orfX without having SCCmec, whereas an ST2198 isolate lacked this locus. CONCLUSION: The primary virulence factors (staphylocoagulase, protein A andalpha-haemolysin) as well as the SE-like toxins of S. argenteus were genetically discriminated from those of S. aureus, revealing the presence of the novel coa-type/subtype (coa-IXd, XIV) in S. argenteus.

    DOI： 10.1099/jmm.0.000869

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  • Prevalence and Molecular Epidemiology of Clinical Isolates of Escherichia coli and Klebsiella pneumoniae Harboring Extended-Spectrum Beta-Lactamase and Carbapenemase Genes in Bangladesh. 国際誌

    Emily Rahman Khan, Meiji Soe Aung, Shyamal Kumar Paul, Salma Ahmed, Nazia Haque, Farid Ahamed, Santana Rani Sarkar, Sangjukta Roy, Mohammad Mustafizur Rahman, Muhammad Chand Mahmud, Muhammad Akram Hossain, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   24 ( 10 )   1568 - 1579   2018年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Spread of Gram-negative bacteria producing extended-spectrum beta-lactamases (ESBLs) and carbapenemases constitutes a growing challenge in control of bacterial infections. In this study, prevalence and genetic characteristics of Escherichia coli and Klebsiella pneumoniae harboring ESBL and/or carbapenemase genes, with other beta-lactamase/resistance genes, were investigated for a total of 375 clinical isolates in Mymensingh located in north-central Bangladesh. The major ESBL gene was blaCTX-M-1 group, which was detected in 33.9% and 51.4% of E. coli and K. pneumoniae, respectively, with CTX-M-15 gene being dominant. SHV-type beta-lactamase genes, including newly identified alleles (SHV-201 and SHV-202) were detected at higher rate in K. pneumoniae (27%). Nine isolates of E. coli (3.9%) harbored carbapenemase genes; blaNDM-1 (phylogenetic group A-sequence type 2104 (A-ST2104), B2-ST73), blaNDM-5 (A-ST167, B2-ST38/ST2659-related STs), and blaNDM-7 (B1-ST101/ST224, D-ST6682). AmpC beta-lactamase genes (blaCMY-2 and blaCMY-42) were detected in E. coli, which mostly harbored blaCTX-M-15 and plasmid-mediated quinolone resistance (PMQR) determinants (aac6'-Ib-cr, qnrB, qnrS, qepA, and oqxAB). A new CMY allele (CMY-160) belonging to CMY-2 group was identified in phylogenetic group D E. coli. Among K. pneumoniae, carbapenemase gene was detected in three isolates (2%); blaNDM-1 in ST11 and ST1322, and blaOXA-181 in ST43 isolate. As well as higher rate of aac6'-Ib-cr in K. pneumoniae (39%), PMQR gene oqxAB was also commonly found among isolates analyzed. These findings indicated spread of blaNDM genes to diverse E. coli clones and emergence of blaOXA-181 in K. pneumoniae, with increased prevalence of ESBLs represented by CTX-M-15 in Bangladesh.

    DOI： 10.1089/mdr.2018.0063

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  • Prevalence of Extended-Spectrum Beta-Lactamase and Carbapenemase Genes in Clinical Isolates of Escherichia coli in Myanmar: Dominance of blaNDM-5 and Emergence of blaOXA-181. 国際誌

    Meiji Soe Aung, Nilar San, Win Win Maw, Thida San, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   24 ( 9 )   1333 - 1344   2018年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The increasing trend of Escherichia coli producing extended-spectrum beta-lactamases (ESBLs) and carbapenemases is a global public health concern. In this study, prevalence and molecular characteristics of E. coli harboring ESBL and carbapenemase genes were investigated for 426 isolates derived from various clinical specimens in a teaching hospital in Yangon, Myanmar, for the 1-year period beginning January 2016. A total of 157 isolates (36.9%) were ESBL producers and harbored CTX-M-1 group genes (146 isolates; blaCTX-M-15, blaCTX-M55) or CTX-M-9 group genes (11 isolates; blaCTX-M-14, blaCTX-M-27). Carbapenem resistance was detected in 35 isolates (8.2%), among which 26 isolates had carbapenemase genes encoding NDM-1 (2 isolates), NDM-4 (6 isolates), NDM-5 (14 isolates), NDM-7 (3 isolates), and OXA-181 (2 isolates). blaNDM-5 was identified in phylogenetic groups A, B1, and D isolates belonging to various genotypes (ST101, ST354, ST405, ST410, ST1196) associated with blaTEM-1, blaCTX-M-15, blaOXA-181, blaCMY-2, blaCMY-6, blaCMY-42, qnrB, qnrS, or aac6'-Ib-cr. While two isolates with blaOXA-181 belonged to phylogenetic group A-ST410, one isolate had also blaNDM-5, as well as blaCTX-M-15 and blaCMY-2, and the other harbored blaCMY-42 and aac6'-Ib-cr, showing different resistance patterns. Phylogenetic group B2 isolates examined were classified into mostly ST131 and had solely blaCTX-M-15 or blaCTX-M-27, harboring more virulence factors than other phylogenetic groups. The present study revealed high prevalence of ESBL genes represented by blaCTX-M-15 and dominance of blaNDM-5 among NDM genes, disseminating to various E. coli clones. Notably, carbapenemase gene encoding OXA-181 was first identified in Myanmar, suggesting its spread together with NDM genes.

    DOI： 10.1089/mdr.2017.0387

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  • Genetic diversity of pneumococcal surface protein A (PspA) in paediatric isolates of non-conjugate vaccine serotypes in Japan. 国際誌

    Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Shigeo Morimoto, Masahiko Ito, Kenji Kudo, Nobumichi Kobayashi

    Journal of medical microbiology   67 ( 8 )   1130 - 1138   2018年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: Among the pneumococcal proteins, pneumococcal surface protein A (PspA) is considered the most promising candidate for a serotype-independent vaccine. This study aimed to investigate the serotype, genetic diversity of PspA, lineage (genotype) and drug resistance traits of pneumococcal isolates from paediatric patients. METHODOLOGY: A total of 678 non-invasive pneumococcal isolates obtained from June to November 2016 were analysed. All isolates were characterized for PspA families, serotypes and macrolide resistance genes. Seventy-one representative isolates of non-vaccine serotypes (NVTs) were genetically analysed for the clade-defining region (CDR) of PspA, as well as multi-locus sequence typing (MLST). RESULTS: The detection rate of NVTs was 87.9 % (n=596), including dominant NVTs 15A (14.5 %, n=98), 35B (11.8 %, n=80), 15C (9.3 %, n=63) and 23A (9.0 %, n=61). Most isolates (96.6 %) possessed macrolide resistance genes erm(B) and/or mef(A/E). PspA families 1, 2 and 3 were detected in 42.3, 56.6 and 0.6 % of isolates, respectively. Nucleotide sequences of CDR showed high identity (90-100 %) within the same PspA clade, although the CDR identity among different PspA families ranged from 53 to 69 %. All isolates of NVTs 23A, 10A, 34, 24, 22F/22A, 33F, 23B and 38 were from PspA family 1, while NVTs 35B, 15C, 15B and 11A/11D isolates were from family 2. In contrast, genetically distinct PspAs were found in NVTs 6C and 15A. PspA family 3/clade 6 was detected in only NVT serotype 37 isolates assigned to ST447 and ST7970, showing the mucoid phenotype. CONCLUSION: The present study revealed the predominance of PspA families 1 and 2 in NVTs, and the presence of family 3 in serotype 37.

    DOI： 10.1099/jmm.0.000775

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  • ミャンマーの大腸菌臨床分離株におけるESBL・カルバペネマーゼ遺伝子の分布状況

    小林 宣道, アウン・メイジソウ, サン・ニラ, モウ・ウィンウィン, 川口谷 充代, 漆原 範子, 鷲見 紋子

    日本衛生学雑誌   73 ( Suppl. )   S261 - S261   2018年3月

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    記述言語：日本語   出版者・発行元：(一社)日本衛生学会  

    医中誌

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  • Species C Rotaviruses in Children with Diarrhea in India, 2010–2013: A Potentially Neglected Cause of Acute Gastroenteritis

    Nobumichi Kobayashi

    Pathogens   2018年2月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/pathogens7010023

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  • Contribution of Type II Topoisomerase Mutations to Fluoroquinolone Resistance in Enterococcus faecium from Japanese Clinical Setting. 国際誌

    Noriko Urushibara, Keisuke Suzaki, Mitsuyo Kawaguchiya, Meiji Soe Aung, Masaaki Shinagawa, Satoshi Takahashi, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   24 ( 1 )   1 - 7   2018年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    High-level fluoroquinolone resistance is conferred by the mutation of conserved serine and acidic amino acids in the quinolone resistance-determining region (QRDR) of the A subunits of the type II topoisomerases, DNA gyrase (GyrA) and topoisomerase IV (ParC). In Japan, fluoroquinolone-resistant Enterococcus faecium continues to emerge in clinical settings. We analyzed 131 Japanese E. faecium clinical isolates for susceptibility to levofloxacin (LVFX), and QRDR mutational status. The bacterial collection had a high percentage of resistance (79%) and showed elevated drug minimal inhibitory concentrations (MICs). Eighty-three isolates had single or combined mutations in gyrA and/or parC; all were resistant to LVFX. A strong correlation was evident between log-transformed MICs and the total number of QRDR mutations (r = 0.7899), confirming the involvement of QRDR mutations in drug resistance, as previously described. Three-dimensional modeling indicated that the amino acid change(s) in QRDR could disrupt the interaction between the enzymes and drugs: the most common cause of quinolone resistance. Interestingly, eight isolates had a single mutation on gyrA and exhibited significantly reduced susceptibility. These data imply that either DNA gyrase or topoisomerase IV can be the primary target of fluoroquinolones, although topoisomerase IV is commonly thought to be the primary target in gram-positive bacteria.

    DOI： 10.1089/mdr.2016.0328

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  • 北海道で分離された小児非侵襲性肺炎球菌の血清型分布の経時的変化

    川口谷 充代, 漆原 範子, 森本 茂雄, 伊藤 政彦, 工藤 兼司, 鷲見 紋子, 小林 宣道

    北海道公衆衛生学雑誌   31 ( 1特別付録 )   35 - 35   2017年11月

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    記述言語：日本語   出版者・発行元：北海道公衆衛生学会  

    医中誌

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  • Association between meteorological factors and reported cases of hand, foot, and mouth disease from 2000 to 2015 in Japan 査読

    A. Sumi, S. Toyoda, K. Kanou, T. Fujimoto, K. Mise, Y. Kohei, A. Koyama, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   145 ( 14 )   2896 - 2911   2017年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1017/S0950268817001820

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  • Prevalence and Genetic Characteristics of Staphylococcus aureus and Staphylococcus argenteus Isolates Harboring Panton-Valentine Leukocidin, Enterotoxins, and TSST-1 Genes from Food Handlers in Myanmar 査読

    Meiji Soe Aung, Thida San, Mya Mya Aye, San Mya, Win Win Maw, Khin Nyein Zan, Wut Hmone Win Htut, Mitsuyo Kawaguchiya, Noriko Urushibara, Nobumichi Kobayashi

    TOXINS   9 ( 8 )   2017年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/toxins9080241

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  • Role of meteorological conditions in reported chickenpox cases in Wuhan and Hong Kong, China 査読

    Banghua Chen, Ayako Sumi, Lei Wang, Wang Zhou, Nobumichi Kobayashi

    BMC INFECTIOUS DISEASES   17   2017年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1186/s12879-017-2640-1

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  • Molecular Characterization of Methicillin-Resistant Staphylococcus aureus from Outpatients in Northern Japan: Increasing Tendency of ST5/ST764 MRSA-IIa with Arginine Catabolic Mobile Element 査読

    Meiji Soe Aung, Mitsuyo Kawaguchiya, Noriko Urushibara, Ayako Sumi, Masahiko Ito, Kenji Kudo, Shigeo Morimoto, Shino Hosoya, Nobumichi Kobayashi

    MICROBIAL DRUG RESISTANCE   23 ( 5 )   616 - 625   2017年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1089/mdr.2016.0176

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  • 【開発途上国における感染症研究支援】バングラデシュにおける産褥期感染症に関する共同研究

    小林 宣道, アーメッド・サルマ, 鷲見 紋子, 漆原 範子, 川口谷 充代, アウン・メイジソウ

    日本衛生学雑誌   72 ( 2 )   106 - 111   2017年5月

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  • Serotype distribution, antimicrobial resistance and prevalence of pilus islets in pneumococci following the use of conjugate vaccines. 国際誌

    Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Masaaki Shinagawa, Satoshi Takahashi, Nobumichi Kobayashi

    Journal of medical microbiology   66 ( 5 )   643 - 650   2017年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: In Japan, the 7-valent pneumococcal vaccine (PCV7) was introduced in 2010 and, in 2013, the PCV7 was replaced with the 13-valent pneumococcal vaccine (PCV13). This study was conducted to investigate serotypes, antimicrobial resistance and prevalence of pilus islets in pneumococcal isolates from inpatients in a Japanese tertiary hospital. METHODOLOGY: From April 2011 to February 2016, 151 isolates [95 (18 children, 77 adults) and 56 (19 children, 37 adults) in the PCV7 and PCV13 periods, respectively] were collected. All isolates were serotyped using genetic methods and were tested for susceptibility to 18 antimicrobials. Unaltered penicillin-binding protein (PBP) genes, macrolide resistance genes and pilus islets were identified by PCR. RESULTS: Between the two periods, the prevalence of non-PCV13 serotypes was shown to increase from 50.0 to 78.9 % in children, and serotype 3 increased from 14.3 to 24.3 % in adults. Six of seven isolates from invasive diseases were assigned to non-PCV13 serotypes. Overall, multidrug resistance (MDR) was detected in 46.4 % of isolates, which included the dominant non-PCV13 serotypes 6E, 15A and 23A (prevalence≥75.0 %). gPRSP (three altered genes pbp1a, pbp2b and pbp2x) and macrolide resistance genes [erm(B) and/or mef(A/E)] were detected in 35.8 and 93.4 % of all isolates, respectively. Pilus islets [PI-1 (clade I, II and III) and/or PI-2] were found in 22.5 % (34/151) of isolates belonging to six different serotypes (19F, 23F, 19A, 6E, 15B and 35B) and 88.2 % (30/34) of these exhibited MDR. CONCLUSION: This study revealed the spread of MDR in several non-PCV13 serotypes and in isolates with pilus islets.

    DOI： 10.1099/jmm.0.000479

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  • 【開発途上国における感染症研究支援】中国・インド・フィリピン・北欧との感染症発生動向に関する共同研究

    鷲見 紋子, 小林 宣道

    日本衛生学雑誌   72 ( 2 )   112 - 122   2017年5月

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  • Whole genome analysis provides evidence for porcine- to- simian interspecies transmission of rotavirus- A 査読

    Ryan Navarro, Meiji Soe Aung, Katalina Cruz, Jennifer Ketzis, Christa Ann Gallagher, Amy Beierschmitt, Yashpal Singh Malik, Nobumichi Kobayashi, Souvik Ghosh

    INFECTION GENETICS AND EVOLUTION   49   21 - 31   2017年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.meegid.2016.12.026

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  • Multidrug Resistance in Non-PCV13 Serotypes of Streptococcus pneumoniae in Northern Japan, 2014 査読

    Mitsuyo Kawaguchiya, Noriko Urushibara, Nobumichi Kobayashi

    MICROBIAL DRUG RESISTANCE   23 ( 2 )   206 - 214   2017年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1089/mdr.2016.0054

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  • Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines 査読

    A. Sumi, E. F. O. Telan, H. Chagan-Yasutan, M. B. Piolo, T. Hattori, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   145 ( 1 )   78 - 86   2017年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1017/S095026881600203X

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  • Distribution of two distinct rotavirus B (RVB) strains in the north-central Bangladesh and evidence for reassortment event among human RVB revealed by whole genomic analysis 査読

    Meiji Soe Aung, Samsoon Nahar, Satoru Aida, Shyamal Kumar Paul, Muhammad Akram Hossain, Salma Ahmed, Nazia Haque, Souvik Ghosh, Yashpal Singh Malik, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Nobumichi Kobayashi

    INFECTION GENETICS AND EVOLUTION   47   77 - 86   2017年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.meegid.2016.11.001

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  • Collaborative Research on Puerperal Infections in Bangladesh.

    Nobumichi Kobayashi, Salma Ahmed, Ayako Sumi, Noriko Urushibara, Mitsuyo Kawaguchiya, Meiji Soe Aung

    Nihon eiseigaku zasshi. Japanese journal of hygiene   72 ( 2 )   106 - 111   2017年

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

    Bangladesh is considered as a high-risk country for emerging infectious diseases because of its high population density, poverty, and unhygienic conditions. Although control efforts have primarily been focused on major infectious diseases such as diarrheal diseases, tuberculosis, malaria, and HIV infection, the prevalence and impact of many local or minor infectious diseases are still unclarified in this country. In this review, we present our recent experience and outcomes of collaborative research on puerperal infection (PI), which is a poorly defined infectious disease in Bangladesh. PI is the most common complication during the perinatal period in developing countries. We investigated the incidence of individual species of aerobic bacteria causing PIs and their drug resistance, and the genetic traits of isolates during the two-year period (2010-2012). The common species of isolates from patients with PIs were Escherichia coli, Enterococcus faecalis, Staphylococcus haemolyticus, Proteus mirabilis, Staphylococcus aureus, and Klebsiella pneumoniae. A remarkable finding was the high rates of resistance to cephalosporins among Gram-negative bacteria harboring extended-spectrum beta-lactamase genes, which were associated with carbapenem resistance in a few isolates. This study defined the importance of control of antimicrobial resistance in Bangladesh, and provided suggestions for the future direction of collaborative research on infectious diseases in Bangladesh.

    DOI： 10.1265/jjh.72.106

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  • Whole genomic analysis of G2P[4] human Rotaviruses in Mymensingh, north-central Bangladesh. 国際誌

    Satoru Aida, Samsoon Nahar, Shyamal Kumar Paul, Muhammad Akram Hossain, Muhammad Rashidul Kabir, Santana Rani Sarkar, Salma Ahmed, Souvik Ghosh, Noriko Urushibara, Mitsuyo Kawaguchiya, Meiji Soe Aung, Ayako Sumi, Nobumichi Kobayashi

    Heliyon   2 ( 9 )   e00168   2016年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Rotavirus A (RVA) is a dominant causative agent of acute gastroenteritis in children worldwide. G2P[4] is one of the most common genotypes among human rotavirus (HRV) strains, and has been persistently prevalent in South Asia including Bangladesh. In the present study, whole genome sequences of a total of 16 G2P[4] HRV strains (8 strains each in 2010 and 2013) detected in Mymensingh, north-central Bangladesh were determined. These strains had typical DS-1-like genotype constellation. Most of gene segments from DS-1 genogroup exhibited high level sequence identities to each other (>98%), while slight diversity was observed for VP1, VP3, and NSP4 genes. By phylogenetic analysis, individual RNA segments were classified into one (V) or two-three lineages (V-VI or V-VII). In terms of lineages (sublineages) of 11 gene segments, the 16 Bangladeshi strains could be further classified into four clades (A-D) containing 8 lineage constellations, revealing the presence of three clades (A-C) with three lineage constellations in 2010, and a single clade (D) with four constellations in 2013. Therefore, co-existence of multiple G2P[4] HRV strains with different lineage constellations, and change in clades for the study period were demonstrated. Although amino acids in the antigenic regions on VP7 and VP4 were mostly identical to those of global G2P[4] strains after 2000, VP4 of clade D RVAs in 2013 had alanine and proline at positions 88 and 114, respectively, which are novel substitutions compared with recent global G2P[4] strains. Replacement of lineage constellations associated with unique amino acid changes in the antigenic region in VP4 suggested continuous genetic evolutionary state for emerging new G2P[4] rotavirus strains in Bangladesh.

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  • Time-series analysis of monthly age-specific numbers of newly registered cases of active tuberculosis in Japan from 1998 to 2013 査読

    Y. Kohei, A. Sumi, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   144 ( 11 )   2401 - 2414   2016年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1017/S0950268816000546

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  • Multispecies reassortant bovine rotavirus strain carries a novel simian G3-like VP7 genotype 査読

    Yashpal Singh Malik, Naveen Kumar, Kuldeep Sharma, Sharad Saurabh, Kuldeep Dhama, Minakshi Prasad, Souvik Ghosh, Krisztian Banyai, Nobumichi Kobayashi, Raj Kumar Singh

    INFECTION GENETICS AND EVOLUTION   41   63 - 72   2016年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.meegid.2016.03.023

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  • バングラデシュにおける産褥期感染症由来の大腸菌と黄色ブドウ球菌の分子疫学的解析

    小林 宣道, アーメッド・サルマ, 川口谷 充代, 漆原 範子, メイジ・ソウアウン, 鷲見 紋子

    日本衛生学雑誌   71 ( Suppl. )   S215 - S215   2016年5月

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    記述言語：英語   出版者・発行元：(一社)日本衛生学会  

    医中誌

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  • Novel Structures and Temporal Changes of Arginine Catabolic Mobile Elements in Methicillin-Resistant Staphylococcus aureus Genotypes ST5-MRSA-II and ST764-MRSA-II in Japan 査読

    Noriko Urushibara, Mitsuyo Kawaguchiya, Mayumi Onishi, Keiji Mise, Meiji Soe Aung, Nobumichi Kobayashi

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   60 ( 5 )   3119 - 3122   2016年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1128/AAC.02356-15

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  • Molecular Detection of Rickettsia felis in Humans, Cats, and Cat Fleas in Bangladesh, 2013-2014 査読

    Rajib Ahmed, Shyamal Kumar Paul, Muhammad Akram Hossain, Salma Ahmed, Muhammad Chand Mahmud, Syeda Anjuman Nasreen, Faria Ferdouse, Rumana Hasan Sharmi, Farid Ahamed, Souvik Ghosh, Noriko Urushibara, Meiji Soe Aung, Nobumichi Kobayashi

    VECTOR-BORNE AND ZOONOTIC DISEASES   16 ( 5 )   356 - 358   2016年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1089/vbz.2015.1886

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  • Whole genomic analysis of a porcine G6P[13] rotavirus strain 査読

    Souvik Ghosh, Ryan Navarro, Yashpal Singh Malik, Arve Lee Willingham, Nobumichi Kobayashi

    VETERINARY MICROBIOLOGY   180 ( 3-4 )   286 - 298   2015年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.vetmic.2015.09.017

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  • Time series analysis of reported cases of hand, foot, and mouth disease from 2010 to 2013 in Wuhan, China 査読

    Banghua Chen, Ayako Sumi, Shin'ichi Toyoda, Quan Hu, Dunjin Zhou, Keiji Mise, Junchan Zhao, Nobumichi Kobayashi

    BMC INFECTIOUS DISEASES   15   2015年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1186/s12879-015-1233-0

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  • The role of temperature in reported chickenpox cases from 2000 to 2011 in Japan 査読

    K. Harigane, A. Sumi, K. Mise, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   143 ( 12 )   2666 - 2678   2015年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1017/S095026881400363X

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  • Drug resistance and molecular epidemiology of aerobic bacteria isolated from puerperal infections in Bangladesh. 国際誌

    Salma Ahmed, Mitsuyo Kawaguchiya, Souvik Ghosh, Shyamal Kumar Paul, Noriko Urushibara, Chand Mahmud, Kamrun Nahar, Mohammad Akram Hossain, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   21 ( 3 )   297 - 306   2015年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Puerperal infection is a common complication during postnatal period in developing countries. Bacterial species, drug resistance, and genetic characteristics were investigated for a total of 470 isolates from puerperal infections in Bangladesh for a 2-year period (2010-2012). The most common species was Escherichia coli (n=98), followed by Enterococcus faecalis (n=54), Staphylococcus haemolyticus (n=33), Proteus mirabilis (n=32), Staphylococcus aureus (n=27), Klebsiella pneumoniae (n=22), and Enterobacter cloacae (n=21). S. aureus and Acinetobacter baumannii were isolated at a higher frequency from wound infections after cesarean section, while E. coli, E. cloacae, and K. pneumoniae were isolated from community-acquired endometritis and urinary tract infections. Resistance to third-generation cephalosporins was frequent for Enterobacteriacae, and was mainly mediated by blaCTX-M-1 group beta-lactamases. The CTX-M gene in E. coli from the four phylogroups was identified as blaCTX-M-15, and phylogroup B2 isolates with blaCTX-M-15 were classified into ST131 with O25b allele, harboring aac(6')-Ib-cr and various virulence factors. Carbapenemase genes blaNDM-1 and blaNDM-7 were identified in one isolate each of phylogroup A E. coli. Methicillin-resistant S. aureus isolates had type IV or V SCCmec, including isolates of ST361 (CC672), which is related to an emerging ST672 clone in the Indian subcontinent. This study revealed the recent epidemiological status of aerobic bacteria causing puerperal infections in Bangladesh, providing useful information to improve clinical practice and infection control.

    DOI： 10.1089/mdr.2014.0219

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  • High Prevalence of Genotype 6E (Putative Serotype 6E) Among Noninvasive/Colonization Isolates of Streptococcus pneumoniae in Northern Japan 査読

    Mitsuyo Kawaguchiya, Noriko Urushibara, Nobumichi Kobayashi

    MICROBIAL DRUG RESISTANCE   21 ( 2 )   209 - 214   2015年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1089/mdr.2014.0181

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  • 7価小児用肺炎球菌結合型ワクチン導入後における肺炎球菌血清型の分布状況

    川口谷 充代, 鷲見 紋子, 小林 宣道

    日本公衆衛生学会総会抄録集   73回   531 - 531   2014年10月

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    記述言語：日本語   出版者・発行元：日本公衆衛生学会  

    医中誌

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  • Seasonality of reported tuberculosis cases from 2006 to 2010 in Wuhan, China 査読

    T. Luo, A. Sumi, D. Zhou, N. Kobayashi, K. Mise, B. Yu, D. Kong, J. Wang, Q. Duan

    EPIDEMIOLOGY AND INFECTION   142 ( 10 )   2036 - 2048   2014年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1017/S0950268813003142

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  • Serotype Distribution and Susceptibility to Penicillin and Erythromycin Among Noninvasive or Colonization Isolates of Streptococcus pneumoniae in Northern Japan: A Cross-Sectional Study in the Pre-PCV7 Routine Immunization Period 査読

    Mitsuyo Kawaguchiya, Noriko Urushibara, Souvik Ghosh, Osamu Kuwahara, Shigeo Morimoto, Masahiko Ito, Kenji Kudo, Nobumichi Kobayashi

    MICROBIAL DRUG RESISTANCE   20 ( 5 )   456 - 465   2014年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1089/mdr.2013.0196

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  • Detection and genetic characterization of PVL-positive ST8-MRSA-IVa and exfoliative toxin D-positive European CA-MRSA-Like ST1931 (CC80) MRSA-IVa strains in Bangladesh. 国際誌

    Shyamal Kumar Paul, Souvik Ghosh, Mitsuyo Kawaguchiya, Noriko Urushibara, Mohammad Akram Hossain, Salma Ahmed, Chand Mahmud, Md Shariful Alam Jilani, Jalaluddin Ashraful Haq, Abdullah Akhtar Ahmed, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   20 ( 4 )   325 - 36   2014年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Severe skin lesions caused by Staphylococcus aureus infection are associated with production from bacterial cells of Panton-Valentine leukocidin (PVL), a typical virulence factor of community-acquired methicillin-resistant S. aureus (CA-MRSA), as well as other toxins represented by exfoliative toxins. Through a retrospective study of 26 S. aureus strains isolated from skin lesions of diabetic patients admitted to a hospital in Bangladesh, 2 PVL-gene-positive MRSA-IVa strains and 8 PVL-negative, exfoliative toxin D (ETD) gene (etd)-positive MRSA-IVa strains were isolated. A PVL-positive MRSA-IVa strain had a type I arginine catabolic mobile element (ACME), belonged to ST8/agr-type I/spa-type t121 (a variant of t008), and harbored blaZ, tet(K), msrA, and aph(3')-IIIa, which are mostly typical characteristics found in USA300, a predominant CA-MRSA clone in the United States. Another PVL-positive MRSA strain, belonging to ST1929 (CC88)/agr-type III/spa-type t3341, was negative for ACME, but possessed blaZ and tet(K). The etd-positive MRSA-IVa strains possessed the epidermal cell differentiation inhibitor B (EDIN-B)-encoding gene (edinB) and belonged to ST1931 (CC80)/agr-type III/spa-type t11023 (a variant of t044), which was genetic trait similar to that of the European CA-MRSA ST80 clone. However, unlike the European ST80 strains, the etd-positive MRSA strains detected in the present study harbored seb, sek, and seq, while they were negative for tet(K), aph(3')-IIIa, and fusB, showing susceptibility to fusidic acid. These findings suggested that etd-positive ST1931 MRSA strains belong to the same lineage as the European ST80 MRSA clone, evolving from a common ancestral clone via acquisition of a different pathogenicity island. This is the first report of a USA300-like MRSA-IV strain, PVL-positive ST1929 (CC88) MRSA-IV, and European ST80 CA-MRSA-like etd-positive ST1931 (CC80) MRSA-IV strains isolated in Bangladesh.

    DOI： 10.1089/mdr.2013.0153

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  • Hospital based surveillance and genetic characterization of rotavirus strains in children (&lt; 5 years) with acute gastroenteritis in Kolkata, India, revealed resurgence of G9 and G2 genotypes during 2011-2013 査読

    Satarupa Mullick, Paulami Mandal, Mukti Kant Nayak, Souvik Ghosh, Papiya De, K. Rajendran, Mihir K. Bhattacharya, Utpala Mitra, Thandavarayan Ramamurthy, Nobumichi Kobayashi, Mamta Chawla-Sarkar

    VACCINE   32   A20 - A28   2014年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.vaccine.2014.03.018

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  • Molecular Epidemiology and Genetic Evolution of the Whole Genome of G3P[8] Human Rotavirus in Wuhan, China, from 2000 through 2013 査読

    Yuan-Hong Wang, Bei-Bei Pang, Souvik Ghosh, Xuan Zhou, Tsuzumi Shintani, Noriko Urushibara, Yu-Wei Song, Ming-Yang He, Man-Qing Liu, Wei-Feng Tang, Jin-Song Peng, Quan Hu, Dun-Jin Zhou, Nobumichi Kobayashi

    PLOS ONE   9 ( 3 )   2014年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1371/journal.pone.0088850

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  • Prevalence and genetic diversity of arginine catabolic mobile element (ACME) in clinical isolates of coagulase-negative staphylococci: Identification of ACME type I variants in Staphylococcus epidermidis 査読

    Mayumi Onishi, Noriko Urushibara, Mitsuyo Kawaguchiya, Souvik Ghosh, Masaaki Shinagawa, Naoki Watanabe, Nobumichi Kobayashi

    INFECTION GENETICS AND EVOLUTION   20   381 - 388   2013年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.meegid.2013.09.018

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  • Genetic diversity of emerging Panton-Valentine leukocidine/arginine catabolic mobile element (ACME)-positive ST8 SCCmec-IVa meticillin-resistant Staphylococcus aureus (MRSA) strains and ACME-positive CC5 (ST5/ST764) MRSA strains in Northern Japan. 国際誌

    Mitsuyo Kawaguchiya, Noriko Urushibara, Souvik Ghosh, Osamu Kuwahara, Shigeo Morimoto, Masahiko Ito, Kenji Kudo, Nobumichi Kobayashi

    Journal of medical microbiology   62 ( Pt 12 )   1852 - 1863   2013年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Panton-Valentine leukocidine (PVL) is a distinctive virulence factor of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA), and arginine catabolic mobile element (ACME) is a staphylococcal genomic island that enhances fitness and the ability of bacterial cells to colonize on skin and mucous membranes. ACME is characteristically found in USA300, which is a predominant CA-MRSA clone [sequence type (ST) 8] in the USA and is spreading globally, and has also been detected in non-ST8 MRSA at low frequency. In Japan, spread of MRSA with PVL and/or ACME and their genetic traits have not yet been well characterized. In the present study, the prevalence and genetic diversity of PVL(+)/ACME(+) MRSA were investigated for 422 MRSA clinical isolates collected from outpatients in northern Japan over a period of 1 year. All the isolates were genotyped for the staphylococcal cassette chromosome mec (SCCmec) and coagulase genes (coa), and screened for PVL and ACME genes. The PVL(+)/ACME(+) isolates were studied further by genetic analysis, including single-nucleotide polymorphism (SNP) analysis based on PVL genes (lukS-PV-lukF-PV), ACME (arc and opp3 clusters) and the sarU promoter region. Among all the isolates examined, PVL genes and ACME were detected in eight (SCCmec-II, n = 1; SCCmec-IV, n = 6; SCCmec-V, n = 1) and 20 (SCCmec-II, n = 14; SCCmec-IV, n = 5; SCCmec-V, n = 1) isolates, respectively. Five isolates were found to have both PVL genes and ACME (type I), and were classified into ST8/spa-t008/agr-I/coa-IIIa, which is the same genetic traits as USA300. Fifteen PVL(-)/ACME(+) isolates had type ΔII-ACME, belonging to either ST5 or ST764 [clonal complex (CC) 5], and spa-t001, -t002 or -t3557. All the ST8 PVL(+)/ACME-I(+) MRSA had identical sequences of PVL genes (haplotype R) and ACME arc/opp3 clusters as those of USA300. In contrast, in the CC5 PVL(-)/ACME-ΔII(+) MRSA, SNPs in the arc cluster were detected in 11 sites (four haplotypes), with some different profiles of virulence/resistance factors. These results indicated single clonality of ST8 PVL(+)/ACME-I(+) MRSA and heterogeneity of CC5 PVL(-)/ACME-ΔII(+) MRSA, and suggest their potential spread in northern Japan.

    DOI： 10.1099/jmm.0.062125-0

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  • Whole genomic analyses of equine group A rotaviruses from Japan: Evidence for bovine-to-equine interspecies transmission and reassortment events 査読

    Souvik Ghosh, Koki Taniguchi, Satoru Aida, Balasubramanian Ganesh, Nobumichi Kobayashi

    Veterinary Microbiology   166 ( 3-4 )   474 - 485   2013年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：3-4  

    DOI： 10.1016/j.vetmic.2013.07.016

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  • Effect of temperature, relative humidity and rainfall on rotavirus infections in Kolkata, India 査読

    A. Sumi, K. Rajendran, T. Ramamurthy, T. Krishnan, G. B. Nair, K. Harigane, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   141 ( 8 )   1652 - 1661   2013年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1017/S0950268812002208

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  • Characterization of Enterococcus faecium with Macrolide Resistance and Reduced Susceptibility to Quinupristin/Dalfopristin in a Japanese Hospital: Detection of Extensive Diversity in erm(B)-Regulator Regions 査読

    Nayuta Isogai, Noriko Urushibara, Mitsuyo Kawaguchiya, Souvik Ghosh, Keisuke Suzaki, Naoki Watanabe, Dianelys Quinones, Nobumichi Kobayashi

    MICROBIAL DRUG RESISTANCE   19 ( 4 )   298 - 307   2013年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1089/mdr.2012.0176

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  • Whole genomic analyses of asymptomatic human G1P[6], G2P[6] and G3P[6] rotavirus strains reveal intergenogroup reassortment events and genome segments of artiodactyl origin 査読

    Souvik Ghosh, Noriko Urushibara, Mamta Chawla-Sarkar, Triveni Krishnan, Nobumichi Kobayashi

    INFECTION GENETICS AND EVOLUTION   16   165 - 173   2013年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.meegid.2012.12.019

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  • Time-series analysis of hepatitis A, B, C and e infections in a large Chinese city: Application to prediction analysis 査読

    A. Sumi, T. Luo, D. Zhou, B. Yu, D. Kong, N. Kobayashi

    Epidemiology and Infection   141 ( 5 )   905 - 915   2013年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1017/S095026881200146X

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  • Characterization of PVL/ACME-positive methicillin-resistant Staphylococcus aureus (genotypes ST8-MRSA-IV and ST5-MRSA-II) isolated from a university hospital in Japan. 国際誌

    Mitsuyo Kawaguchiya, Noriko Urushibara, Dai Yamamoto, Toshiharu Yamashita, Masaaki Shinagawa, Naoki Watanabe, Nobumichi Kobayashi

    Microbial drug resistance (Larchmont, N.Y.)   19 ( 1 )   48 - 56   2013年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The ST8 methicillin-resistant Staphylococcus aureus (MRSA) with Staphylococcal cassette chromosome mec (SCCmec) type IVa, known as USA300, is a prevalent community-acquired MRSA (CA-MRSA) clone in the United States and has been spreading worldwide. The USA300 characteristically harbors Panton-Valentine Leukocidin (PVL) genes and the arginine catabolic mobile element (ACME, type I). Prevalence and molecular characteristics of PVL(+) and/or ACME(+) S. aureus were investigated in a university hospital located in northern Japan, for 1,366 S. aureus isolates, including 601 MRSA strains derived from clinical specimens collected from 2008 to 2010. The PVL gene was identified in three MRSA strains with SCCmec IV, which belonged to ST8, spa type t008, coagulase type III, and agr type I. Two PVL-positive MRSA strains had also type I ACME, and were isolated from skin abscess of outpatients who have not travelled abroad recently. One of these PVL(+)/ACME(+) strains carried tet(K), msrA, and aph(3')-IIIa, showing resistance to kanamycin, tetracycline, erythromycin, and ciprofloxacin, suggesting acquisition of more resistance than ST8 CA-MRSA reported in Japan previously. In contrast, another PVL(+)/ACME(+) strain and a PVL(+)/ACME(-) strain were susceptible to more antimicrobials and had less virulence factors than PVL(-)/ACME(+) MRSA strains. Besides the two PVL(+) MRSA strains, ACME (type-ΔII) was identified into seven MRSA strains with SCCmec II belonging to ST5, one of the three spa types (t002, t067, and t071), coagulase type II, and agr type II. These PVL(-)/ACME(+) MRSA strains showed multiple drug resistance and harbored various toxin genes as observed for ST5 PVL(-)/ACME(-) MRSA-II. The present study suggested the spread of ST8-MRSA-IV in northern Japan, and a potential significance of ACME-positive ST5-MRSA-II as an emerging MRSA clone in a hospital.

    DOI： 10.1089/mdr.2012.0089

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  • The origin of two rare human P[10] rotavirus strains. 国際誌

    Souvik Ghosh, Noriko Urushibara, Mitsuyo Kawaguchiya, Tsuzumi Shintani, Nobumichi Kobayashi

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases   13   292 - 300   2013年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The Group A rotavirus (RVA) P[10] is a rare genotype of the RVA VP4 gene. To date, the whole genome sequence of only a single P[10] RVA strain, RVA/Human-tc/IDN/69M/1980/G8P4[10], has been determined, revealing a DS-1-like genotype constellation. Whole genomic analyses of P[10] RVA strains with other VP7 genotypes are essential to obtain conclusive data on the origin and genetic diversity of the P10] RVAs. In the present study, the whole genome of a human G4P[10] RVA strain, RVA/Human-tc/IDN/57M/1980/G4P[10], was analyzed. Strain 57M exhibited an unusual G4-P[10]-I1-R1-C1-M1-A1-N1-T2-E1-H2 genotype constellation, and was found to originate from intergenogroup reassortment events involving acquisition of RVA strain 69M-like VP4, NSP3 and NSP5 genes by a co-circulating Wa-like human G4 RVA strain. Although the reference P[10] strain, 69M, exhibits a DS-1-like genotype constellation, the exact origin of this RVA remains to be elucidated. By detailed phylogenetic analyses, we found that the VP1-VP3, VP6, NSP2 and NSP4 genes of 69M originated from artiodactyl and/or artiodactyl-like human P[14] strains, whilst its NSP1, NSP3 and NSP5 genes were more related to those of typical human DS-1-like strains than those of other RVAs. On the other hand, the origin of the VP4 gene of 69M could not be established. Nevertheless, these observations clearly indicated that strain 69M might have originated from reassortment events involving at least the artiodactyl or artiodactyl-like human RVAs and the typical human DS-1-like strains. The present study provided rare evidence for intergenogroup reassortment events involving co-circulating typical human Wa-like RVAs and unusual RVAs of the DS-1-like genogroup, and revealed the presence of artiodactyl-like genes in a human P[10] strain, highlighting the complex evolutionary patterns of the P[10] RVAs.

    DOI： 10.1016/j.meegid.2012.10.021

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  • Emerging trends in the epidemiology of human astrovirus infection among infants, children and adults hospitalized with acute watery diarrhea in Kolkata, India 査読

    Madhusudhan Pativada, Seegekote Mariyappa Nataraju, Balasubramanian Ganesh, Krishnan Rajendran, Thandavarayan Ramamurthy, Sandipan Ganguly, Mihir Kumar Bhattacharya, Mrinmoy Ghosh, Nobumichi Kobayashi, Triveni Krishnan

    INFECTION GENETICS AND EVOLUTION   12 ( 8 )   1685 - 1693   2012年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.meegid.2012.07.018

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  • Identification of common human host genes involved in pathogenesis of different rotavirus strains: An attempt to recognize probable antiviral targets 査読

    Parikshit Bagchi, Satabdi Nandi, Shiladitya Chattopadhyay, Rahul Bhowmick, Umesh Chandra Halder, Mukti Kant Nayak, Nobumichi Kobayashi, Mamta Chawla-Sarkar

    VIRUS RESEARCH   169 ( 1 )   144 - 153   2012年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.virusres.2012.07.021

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  • Two novel arginine catabolic mobile elements and staphylococcal chromosome cassette mec composite islands in community-acquired methicillin-resistant Staphylococcus aureus genotypes ST5-MRSA-V and ST5-MRSA-II 査読

    Noriko Urushibara, Mitsuyo Kawaguchiya, Nobumichi Kobayashi

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   67 ( 8 )   1828 - 1834   2012年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/jac/dks157

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  • Whole-genomic analysis of a human G1P[9] rotavirus strain reveals intergenogroup-reassortment events 査読

    Souvik Ghosh, Tsuzumi Shintani, Noriko Urushibara, Koki Taniguchi, Nobumichi Kobayashi

    JOURNAL OF GENERAL VIROLOGY   93   1700 - 1705   2012年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1099/vir.0.043026-0

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  • Whole Genomic Analysis of Human G1P[8] Rotavirus Strains From Different Age Groups in China 査読

    Tsuzumi Shintani, Souvik Ghosh, Yuan-Hong Wang, Xuan Zhou, Dun-Jin Zhou, Nobumichi Kobayashi

    VIRUSES-BASEL   4 ( 8 )   1289 - 1304   2012年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/v4081289

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  • Whole genomic analysis reveals the porcine origin of human G9P[19] rotavirus strains Mc323 and Mc345 査読

    Souvik Ghosh, Noriko Urushibara, Koki Taniguchi, Nobumichi Kobayashi

    INFECTION GENETICS AND EVOLUTION   12 ( 2 )   471 - 477   2012年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.meegid.2011.12.012

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  • Prevalence of human rotavirus genotypes in Wuhan, China, during 2008-2011: changing trend of predominant genotypes and emergence of strains with the P[8]b subtype of the VP4 gene 査読

    Yuan-Hong Wang, Xuan Zhou, Souvik Ghosh, Dun-Jin Zhou, Bei-Bei Pang, Jin-Song Peng, Quan Hu, Nobumichi Kobayashi

    ARCHIVES OF VIROLOGY   156 ( 12 )   2221 - 2231   2011年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s00705-011-1122-9

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  • Virulence Factors and Genetic Characteristics of Methicillin-Resistant and -Susceptible Staphylococcus aureus Isolates in Myanmar 査読

    Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Tin Sabai Aung, San Mya, Thidar San, Khin Myat Nwe, Nobumichi Kobayashi

    MICROBIAL DRUG RESISTANCE   17 ( 4 )   525 - 535   2011年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1089/mdr.2011.0061

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  • Detection and full genomic analysis of G6P[9] human rotavirus in Japan. 査読 国際誌

    Dai Yamamoto, Mitsuyo Kawaguchiya, Souvik Ghosh, Maho Ichikawa, Kei Numazaki, Nobumichi Kobayashi

    Virus genes   43 ( 2 )   215 - 23   2011年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A rare genotype G6P[9] was identified in two human group A rotavirus strains designated as KF14 and KF17, that were detected in stool specimens from children with diarrhea in Japan. VP7 gene sequences of these two strains were identical and genetically closely related to G6 human rotavirus strains reported in European countries and the United States. To our knowledge, this is the first report of detection of a G6 human rotavirus in Japan. For further genetic analysis to elucidate the origin of the G6 rotavirus, nearly full-length sequences of all 11 RNA segments were determined for the KF17 strain. The complete genomic constellation of KF17 was determined as G6-P[9]-I2-R2-C2-M2-A3-N2-T3-E3-H3, a novel genotype constellation for human rotavirus. Phylogenetic analysis indicated that VP6, VP1-3, and NSP2 genes of KF17 clustered with bovine-like G6 human strains and some animal strains into sub-lineages distinct from those of common DS-1-like G2 human rotaviruses. On the other hand, KF17 genes encoding VP4, NSP1, and NSP3-5 showed high sequence identities to the human G3P[9] strain AU-1, and clustered with AU-1 and some feline strains within the same lineage. These findings suggested that the G6P[9] human rotavirus detected in Japan may have occurred through reassortment among uncommon bovine-like human rotaviruses and human/feline AU-1-like rotaviruses.

    DOI： 10.1007/s11262-011-0624-6

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  • Whole-genome analysis reveals the complex evolutionary dynamics of Kenyan G2P[4] human rotavirus strains 査読

    Souvik Ghosh, Noriaki Adachi, Zipporah Gatheru, James Nyangao, Dai Yamamoto, Masaho Ishino, Noriko Urushibara, Nobumichi Kobayashi

    JOURNAL OF GENERAL VIROLOGY   92   2201 - 2208   2011年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1099/vir.0.033001-0

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  • Active Participation of Cellular Chaperone Hsp90 in Regulating the Function of Rotavirus Nonstructural Protein 3 (NSP3) 査読

    Dipanjan Dutta, Shiladitya Chattopadhyay, Parikshit Bagchi, Umesh Chandra Halder, Satabdi Nandi, Anupam Mukherjee, Nobumichi Kobayashi, Koki Taniguchi, Mamta Chawla-Sarkar

    JOURNAL OF BIOLOGICAL CHEMISTRY   286 ( 22 )   20065 - 20077   2011年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1074/jbc.M111.231878

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  • Analysis of Staphylococcal Cassette Chromosome mec in Staphylococcus haemolyticus and Staphylococcus sciuri: Identification of a Novel ccr Gene Complex with a Newly Identified ccrA Allotype (ccrA7) 査読

    Noriko Urushibara, Shyamal Kumar Paul, Mohammad Akram Hossain, Mitsuyo Kawaguchiya, Nobumichi Kobayashi

    MICROBIAL DRUG RESISTANCE   17 ( 2 )   291 - 297   2011年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1089/mdr.2010.0144

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  • Molecular Characteristics of Community-Acquired Methicillin-Resistant Staphylococcus aureus in Hokkaido, Northern Main Island of Japan: Identification of Sequence Types 6 and 59 Panton-Valentine Leucocidin-Positive Community-Acquired Methicillin-Resistant Staphylococcus aureus 査読

    Mitsuyo Kawaguchiya, Noriko Urushibara, Osamu Kuwahara, Masahiko Ito, Keiji Mise, Nobumichi Kobayashi

    MICROBIAL DRUG RESISTANCE   17 ( 2 )   241 - 250   2011年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1089/mdr.2010.0136

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  • Full genomic analyses of two human G2P[4] rotavirus strains detected in 2005: identification of a caprine-like VP3 gene 査読

    Souvik Ghosh, Shyamal Kumar Paul, Mohammad Akram Hossain, Mohammed Mahbub Alam, Muzahed Uddin Ahmed, Nobumichi Kobayashi

    JOURNAL OF GENERAL VIROLOGY   92   1222 - 1227   2011年5月

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    DOI： 10.1099/vir.0.029868-0

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  • Emergence of G9 as a Predominant Genotype of Human Rotaviruses in Cuba 査読

    Maria de los Angeles Ribas, Shigeo Nagashima, Annely Calzado, Gretel Acosta, Yahisel Tejero, Yanislet Cordero, Daynelid Piedra, Nobumichi Kobayashi

    JOURNAL OF MEDICAL VIROLOGY   83 ( 4 )   738 - 744   2011年4月

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    DOI： 10.1002/jmv.22020

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  • Full Genomic Analysis of a G8P[1] Rotavirus Strain Isolated From an Asymptomatic Infant in Kenya Provides Evidence for an Artiodactyl-to-Human Interspecies Transmission Event 査読

    Souvik Ghosh, Zipporah Gatheru, James Nyangao, Noriaki Adachi, Noriko Urushibara, Nobumichi Kobayashi

    JOURNAL OF MEDICAL VIROLOGY   83 ( 2 )   367 - 376   2011年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/jmv.21974

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  • Influence of relative humidity in Vibrio cholerae infection: A time series model 査読

    K. Rajendran, A. Sumi, M. K. Bhattachariya, B. Manna, D. Sur, N. Kobayashi, T. Ramamurthy

    INDIAN JOURNAL OF MEDICAL RESEARCH   133 ( 2 )   138 - 145   2011年2月

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  • Whole-genome characterization of human group C rotaviruses: identification of two lineages in the VP3 gene 査読

    Dai Yamamoto, Souvik Ghosh, Mitsutaka Kuzuya, Yuan-Hong Wang, Xuan Zhou, Mamta Chawla-Sarkar, Shyamal Kumar Paul, Masaho Ishino, Nobumichi Kobayashi

    JOURNAL OF GENERAL VIROLOGY   92   361 - 369   2011年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1099/vir.0.027375-0

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  • Study on the effect of measles control programmes on periodic structures of disease epidemics in a large Chinese city 査読

    T. Luo, A. Sumi, D. Zhou, K. Kamo, B. Yu, D. Zhao, K. Mise, N. Kobayashi

    EPIDEMIOLOGY AND INFECTION   139 ( 2 )   257 - 264   2011年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1017/S0950268810001056

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  • Full genomic analysis of a simian SA11-like G3P[2] rotavirus strain isolated from an asymptomatic infant: Identification of novel VP1, VP6 and NSP4 genotypes 査読

    Souvik Ghosh, Zipporah Gatheru, James Nyangao, Noriaki Adachi, Noriko Urushibara, Nobumichi Kobayashi

    INFECTION GENETICS AND EVOLUTION   11 ( 1 )   57 - 63   2011年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.meegid.2010.10.010

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  • Time Series Analysis of Incidence Data of Influenza in Japan 査読

    Ayako Sumi, Ken-ichi Kamo, Norio Ohtomo, Keiji Mise, Nobumichi Kobayashi

    JOURNAL OF EPIDEMIOLOGY   21 ( 1 )   21 - 29   2011年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.2188/jea.JE20090162

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  • Complete genome constellation of a caprine group A rotavirus strain reveals common evolution with ruminant and human rotavirus strains 査読

    Souvik Ghosh, Mohammed Mahbub Alam, Muzahed Uddin Ahmed, Rafiqul Islam Talukdar, Shyamal Kumar Paul, Nobumichi Kobayashi

    JOURNAL OF GENERAL VIROLOGY   91   2367 - 2373   2010年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1099/vir.0.022244-0

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  • Rotavirus Nonstructural Protein 1 Suppresses Virus-Induced Cellular Apoptosis To Facilitate Viral Growth by Activating the Cell Survival Pathways during Early Stages of Infection 査読

    Parikshit Bagchi, Dipanjan Dutta, Shiladitya Chattopadhyay, Anupam Mukherjee, Umesh Chandra Halder, Sagartirtha Sarkar, Nobumichi Kobayashi, Satoshi Komoto, Koki Taniguchi, Mamta Chawla-Sarkar

    JOURNAL OF VIROLOGY   84 ( 13 )   6834 - 6845   2010年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1128/JVI.00225-10

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  • Identification of staphylocoagulase genotypes I-X and discrimination of type IV and V subtypes by multiplex PCR assay for clinical isolates of Staphylococcus aureus.

    Mina Hirose, Nobumichi Kobayashi, Souvik Ghosh, Shyamal Kumar Paul, Tzuhsiang Shen, Noriko Urushibara, Mitsuyo Kawaguchiya, Masaaki Shinagawa, Naoki Watanabe

    Japanese journal of infectious diseases   63 ( 4 )   257 - 63   2010年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Staphylocoagulase (SC) is a major phenotypic determinant of Staphylococcus aureus. Antigenic specificity of SC (SC serotype) has been classified into at least 10 types and employed as an epidemiological marker. In the present study, from the sequence information of SC genes, a novel multiplex PCR assay was developed to determine SC genotypes (SC types) I-X corresponding to SC serotypes I-X, respectively, and to discriminate two subtypes of SC types IV and V. Two PCR reactions (Sc-R1 and Sc-R2) for a single isolate were designed for assigning common SC types in S. aureus isolates from humans (I-VIII and X). When amplicon was not produced, an additional PCR (Sc-R3) was performed to assign SC type IX or subtype Vb. Subtypes IVa and IVb were discriminated by an additional PCR (Sc-R4). SC types were discriminated successfully for the S. aureus strains with established SC types I-X including two subtypes of IV and V. The multiplex PCR assay established in this study could assign SC types for S. aureus clinical isolates at a high determination rate, providing more accurate information on incidence of SC types, and was considered to be useful for epidemiologic characterization of S. aureus.

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  • Full Genomic Analysis of a Porcine-Bovine Reassortant G4P[6] Rotavirus Strain R479 Isolated From an Infant in China 査読

    Yuan-Hong Wang, Nobumichi Kobayashi, Shigeo Nagashima, Xuan Zhou, Souvik Ghosh, Jin-Song Peng, Quan Hu, Dun-Jin Zhou, Zhan-Qiu Yang

    JOURNAL OF MEDICAL VIROLOGY   82 ( 6 )   1094 - 1102   2010年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/jmv.21760

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  • Relationship of cholera incidence to El Nino and solar activity elucidated by time-series analysis 査読

    K. Ohtomo, N. Kobayashi, A. Sumi, N. Ohtomo

    EPIDEMIOLOGY AND INFECTION   138 ( 1 )   99 - 107   2010年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1017/S0950268809990203

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  • Detection of Group B Rotavirus in an Adult With Acute Gastroenteritis in Yangon, Myanmar 査読

    Tin Sabai Aung, Nobumichi Kobayashi, Shigeo Nagashima, Souvik Ghosh, Meiji Soe Aung, Khin Yi Oo, Ne Win

    JOURNAL OF MEDICAL VIROLOGY   81 ( 11 )   1968 - 1974   2009年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/jmv.21613

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  • The molecular chaperone heat shock protein-90 positively regulates rotavirus infectionx 査読

    Dipanjan Dutta, Parikshit Bagchi, Arunachal Chatterjee, Mukti Kant Nayak, Anupam Mukherjee, Shiladitya Chattopadhyay, Shigeo Nagashima, Nobumichi Kobayashi, Satoshi Komoto, Koki Taniguchi, Mamta Chawla-Sarkar

    VIROLOGY   391 ( 2 )   325 - 333   2009年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.virol.2009.06.044

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  • Predicting the incidence of human campylobacteriosis in Finland with time series analysis 査読

    Ayako Sumi, Harri Hemila, Keiji Mise, Nobumichi Kobayashi

    APMIS   117 ( 8 )   614 - 622   2009年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/j.1600-0463.2009.02507.x

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  • Phylogenetic Analysis of Rotaviruses With Predominant G3 and Emerging G9 Genotypes From Adults and Children in Wuhan, China 査読

    Yuan-Hong Wang, Nobumichi Kobayashi, Xuan Zhou, Shigeo Nagashima, Ze-Rong Zhu, Jin-Song Peng, Man-Qing Liu, Quan Hu, Dun-Jin Zhou, Shojiro Watanabe, Masaho Ishino

    JOURNAL OF MEDICAL VIROLOGY   81 ( 2 )   382 - 389   2009年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/jmv.21387

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  • Spectral Analysis of Spatial Series Data of Pathologic Tissue: A Study on Small Intestine in ICR Mouse 査読

    Keiji Mise, Ayako Sumi, Nobumichi Kobayashi, Toshihiko Torigoe, Norio Ohtomo

    JAPANESE JOURNAL OF APPLIED PHYSICS   48 ( 1 )   017001-1 - 017001-9   2009年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1143/JJAP.48.017001

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  • Increase in prevalence of human group A rotavirus G9 strains as an important VP7 genotype among children in eastern India 査読

    Sudipta Samajdar, Souvik Ghosh, Mamlta Chawla-Sarkar, Utpala Mitra, Phalguni Dutta, Nobumichi Kobayashi, Trailokya N. Naik

    JOURNAL OF CLINICAL VIROLOGY   43 ( 3 )   334 - 339   2008年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.jcv.2008.07.007

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  • Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus rotavirus 査読

    Shigeo Nagashima, Nobumichi Kobayashi, Masaho Ishino, Mohammed Mahbub Alam, Muzahed Uddin Ahmed, Shyamal Kumar Paul, Balasubramanian Ganesh, Mamta Chawla-Sarkar, Triveni Krishnan, Trailokya Nath Naik, Yuan-Hong Wang

    JOURNAL OF MEDICAL VIROLOGY   80 ( 11 )   2023 - 2033   2008年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/jmv.21286

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  • Phylogenetic analysis of rotaviruses with genotypes G1, G2, G9 and G12 in Bangladesh: evidence for a close relationship between rotaviruses from children and adults 査読

    Shyamal Kumar Paul, Nobumichi Kobayashi, Shigeo Nagashima, Masaho Ishino, Shojiro Watanabe, Mohammed Mahbub Alam, Muzahed Uddin Ahmed, Mohammad Akram Hossain, Trailokya Nath Naik

    ARCHIVES OF VIROLOGY   153 ( 11 )   1999 - 2012   2008年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s00705-008-0212-9

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  • Molecular characterization of rare bovine group A rotavirus G15P[11] and G15P[21] strains from eastern India: identification of simian SA11-like VP6 genes in G15P[21] strains 査読

    Souvik Ghosh, Sudipta Samajdar, Manju Sinha, Nobumichi Kobayashi, Koki Taniguchi, Trailokya N. Naik

    VIRUS GENES   37 ( 2 )   241 - 249   2008年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s11262-008-0260-y

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  • Diversity of staphylocoagulase and identification of novel variants of staphylocoagulase gene in Staphylococcus aureus 査読

    Marie Kinoshita, Nobumichi Kobayashi, Shigeo Nagashima, Masaho Ishino, Seiko Otokozawa, Keiji Mise, Ayako Sumi, Hiroyuki Tsutsumi, Nobuyuki Uehara, Naoki Watanabe, Miyoko Endo

    MICROBIOLOGY AND IMMUNOLOGY   52 ( 7 )   334 - 348   2008年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/j.1348-0421.2008.00045.x

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  • Study of the effect of vaccination on periodic structures of measles epidemics in Japan 査読

    Ayako Sumi, Ken-ichi Kam, Norio Ohtomo, Nobumichi Kobayashi

    MICROBIOLOGY AND IMMUNOLOGY   51 ( 9 )   805 - 814   2007年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • Analysis of genetic factors related to preferential selection of the NSP1 gene segment observed in mixed infection and multiple passage of rotaviruses 査読

    M. Mahbub Alam, N. Kobayashi, M. Ishino, T. N. Naik, K. Taniguchi

    ARCHIVES OF VIROLOGY   151 ( 11 )   2149 - 2159   2006年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s00705-006-0795-y

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  • Characterization of VP1, VP2 and VP3 gene segments of a human rotavirus closely related to porcine strains 査読

    Vici Varghese, Souvik Ghosh, Soma Das, Sujit Kumar Bhattacharya, Triveni Krishnan, Parimal Karmakar, Nobumichi Kobayashi, Trailokya Nath Naik

    VIRUS GENES   32 ( 3 )   241 - 247   2006年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s11262-005-6908-y

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  • Detection of a novel aph(2″) allele (aph[2″]-Ie) conferring high-level gentamicin resistance and a spectinomycin resistance gene ant(9)-Ia (aad9) in clinical isolates of enterococci 査読

    Mohammed Mahbub Alam, Nobumichi Kobayashi, Masaho Ishino, Ayako Sumi, Ken-Ichiro Kobayashi, Nobuyuki Uehara, Naoki Watanabe

    Microbial Drug Resistance   11 ( 3 )   239 - 247   2005年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1089/mdr.2005.11.239

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  • Proportion of sporadic gastroenteritis cases caused by rotavirus, norovirus, adenovirus and bacteria in Japan from January 2000 to December 2003 査読

    A Sumi, N Kobayashi, N Ohtomo

    MICROBIOLOGY AND IMMUNOLOGY   49 ( 8 )   745 - 756   2005年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/j.1348-0421.2005.tb03665.x

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  • Phylogenetic analysis of a human group B rotavirus WH-1 detected in China in 2002 査読

    JH Yang, N Kobayashi, YH Wang, Zhou, X, Y Li, DJ Zhou, ZH Hu, M Ishino, MM Alam, TN Naik, MU Ahmed

    JOURNAL OF MEDICAL VIROLOGY   74 ( 4 )   662 - 667   2004年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/jmv.20222

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  • Genetic analysis of group B human rotaviruses detected in Bangladesh in 2000 and 2001 査読

    MU Ahmed, N Kobayashi, M Wakuda, T Sanekata, K Taniguchi, A Kader, TN Naik, M Ishino, MM Alam, K Kojima, K Mise, A Sumi

    JOURNAL OF MEDICAL VIROLOGY   72 ( 1 )   149 - 155   2004年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/jmv.10546

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  • Serologic and genomic characterization of a G12 human rotavirus in Thailand 査読

    M Wakuda, S Nagashima, N Kobayashi, Y Pongsuwanna, K Taniguchi

    JOURNAL OF CLINICAL MICROBIOLOGY   41 ( 12 )   5764 - 5769   2003年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1128/JCM.41.12.5764-5769.2003

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  • Construction of an infectious cDNA clone of aichi virus (a new member of the family Picornaviridae) and mutational analysis of a stem-loop structure at the 5′ end of the genome

    J. Sasaki, Y. Kusuhara, Y. Maeno, N. Kobayashi, T. Yamashita, K. Sakae, N. Takeda, K. Taniguchi

    Journal of Virology   75 ( 17 )   8021 - 8030   2001年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1128/JVI.75.17.8021-8030.2001

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  • Preferential selection of heterologous G3-VP7 gene in the genetic background of simian rotavirus SA11 detected by using a homotypic single-VP7 gene-substitution reassortant 査読

    J Okada, N Kobayashi, K Taniguchi, S Urasawa

    ANTIVIRAL RESEARCH   38 ( 1 )   15 - 24   1998年4月

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  • Genomic diversity of mec regulator genes in methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis

    N Kobayashi, K Taniguchi, K Kojima, S Urasawa, N Uehara, Y Omizu, Y Kishi, A Yagihashi, Kurokawa, I, N Watanabe

    EPIDEMIOLOGY AND INFECTION   117 ( 2 )   289 - 295   1996年10月

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  • Selection of rotavirus VP7 gene in the genetic background of simian rotavirus SA11: Implications for rotavirus reassortant vaccine development 査読

    N Kobayashi, J Okada, K Taniguchi, T Urasawa, S Urasawa

    ANTIVIRAL RESEARCH   31 ( 3 )   185 - 190   1996年7月

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  • Species-specific and interspecies relatedness of NSP1 sequences in human, porcine, bovine, feline, and equine rotavirus strains 査読

    K Kojima, K Taniguchi, N Kobayashi

    ARCHIVES OF VIROLOGY   141 ( 1 )   1 - 12   1996年

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  • G (VP7) serotype-dependent preferential VP7 gene selection detected in the genetic background of simian rotavirus SA11 査読

    N Kobayashi, K Taniguchi, K Kojima, T Urasawa, S Urasawa

    ARCHIVES OF VIROLOGY   141 ( 7 )   1167 - 1176   1996年

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  • Analysis of methicillin-resistant and methicillin-susceptible Staphylococcus aureus by a molecular typing method based on coagulase gene polymorphisms

    N Kobayashi, K Taniguchi, K Kojima, S Urasawa, N Uehara, Y Omizu, Y Kishi, A Yagihashi, Kurokawa, I

    EPIDEMIOLOGY AND INFECTION   115 ( 3 )   419 - 426   1995年12月

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  • PREFERENTIAL SELECTION OF SPECIFIC ROTAVIRUS GENE SEGMENTS IN COINFECTION AND MULTIPLE PASSAGES WITH REASSORTANT VIRUSES AND THEIR PARENTAL STRAIN 査読

    N KOBAYASHI, K TANIGUCHI, T URASAWA, S URASAWA

    RESEARCH IN VIROLOGY   146 ( 5 )   333 - 342   1995年9月

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  • NONRANDOM SELECTION OF GENE SEGMENT-3 AND RANDOM SELECTION OF GENE SEGMENT-5 OBSERVED IN REASSORTANTS GENERATED IN-VITRO BETWEEN ROTAVIRUS SA11 AND RRV 査読

    N KOBAYASHI, K KOJIMA, K TANIGUCHI, T URASAWA, S URASAWA

    RESEARCH IN VIROLOGY   146 ( 1 )   53 - 59   1995年1月

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  • DETECTION OF MECA, FEMA, AND FEMB GENES IN CLINICAL STRAINS OF STAPHYLOCOCCI USING POLYMERASE CHAIN-REACTION

    N KOBAYASHI, H WU, K KOJIMA, K TANIGUCHI, S URASAWA, N UEHARA, Y OMIZU, Y KISHI, A YAGIHASHI, KUROKAWA, I

    EPIDEMIOLOGY AND INFECTION   113 ( 2 )   259 - 266   1994年10月

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  • GENOTYPIC DIVERSITY OF REASSORTANTS BETWEEN SIMIAN ROTAVIRUS SA11 AND HUMAN ROTAVIRUSES HAVING DIFFERENT ANTIGENIC SPECIFICITIES AND RNA PATTERNS 査読

    N KOBAYASHI, K KOJIMA, K TANIGUCHI, T URASAWA, S URASAWA

    RESEARCH IN VIROLOGY   145 ( 5 )   303 - 311   1994年9月

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  • EFFECT OF THE SELECTION PRESSURE WITH ANTI-VP7 AND ANTI-VP4 NEUTRALIZING MONOCLONAL-ANTIBODIES ON REASSORTANT FORMATION BETWEEN 2 HUMAN ROTAVIRUSES 査読

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  • EFFICIENT PRODUCTION OF ANTIGENIC MOSAIC REASSORTANTS OF ROTAVIRUS WITH THE AID OF ANTI-VP4 AND ANTI-VP7 NEUTRALIZING MONOCLONAL-ANTIBODIES 査読

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    JOURNAL OF VIROLOGICAL METHODS   44 ( 1 )   25 - 34   1993年9月

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  • ANALYSIS OF GENE SELECTION IN REASSORTANT FORMATION BETWEEN CANINE ROTAVIRUS K9 AND HUMAN ROTAVIRUSES WITH DIFFERENT ANTIGENIC SPECIFICITIES 査読

    N KOBAYASHI, K TANIGUCHI, T URASAWA, S URASAWA

    RESEARCH IN VIROLOGY   144 ( 5 )   361 - 370   1993年9月

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  • REACTIVITY OF ANTI-HUMAN ROTAVIRUS VP4 NEUTRALIZING MONOCLONAL-ANTIBODIES WITH ANIMAL ROTAVIRUSES AND WITH UNUSUAL HUMAN ROTAVIRUSES HAVING DIFFERENT P-SEROTYPE AND G-SEROTYPE 査読

    N KOBAYASHI, K TANIGUCHI, T URASAWA, S URASAWA

    RESEARCH IN VIROLOGY   144 ( 3 )   201 - 207   1993年5月

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  • CHARACTERIZATION OF HUMAN ROTAVIRUS STRAINS CAUSING GASTROENTERITIS IN KENYA 査読

    Z GATHERU, N KOBAYASHI, N ADACHI, S CHIBA, J MULI, P OGAJA, J NYANGAO, E KIPLAGAT, PM TUKEI

    EPIDEMIOLOGY AND INFECTION   110 ( 2 )   419 - 423   1993年4月

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  • ロタウイルスの血清型

    浦沢 正三, 谷口 孝喜, 小林 宣道

    ウイルス   42 ( 2 )   145 - 153   1992年

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    その他リンク： https://jlc.jst.go.jp/DN/JALC/00079226745?from=CiNii

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  • ANALYSIS OF HUMAN ROTAVIRUS STRAINS PREVAILING IN BANGLADESH IN RELATION TO NATIONWIDE FLOODS BROUGHT BY THE 1988 MONSOON 査読

    MU AHMED, S URASAWA, K TANIGUCHI, T URASAWA, N KOBAYASHI, F WAKASUGI, AIMM ISLAM, HA SAHIKH

    JOURNAL OF CLINICAL MICROBIOLOGY   29 ( 10 )   2273 - 2279   1991年10月

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  • ANALYSIS OF THE NEUTRALIZATION EPITOPES ON HUMAN ROTAVIRUS VP7 RECOGNIZED BY MONOTYPE-SPECIFIC MONOCLONAL-ANTIBODIES 査読

    N KOBAYASHI, K TANIGUCHI, T URASAWA, S URASAWA

    JOURNAL OF GENERAL VIROLOGY   72   1855 - 1861   1991年8月

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  • ANTIBODY-RESPONSE TO SEROTYPE-SPECIFIC AND CROSS-REACTIVE NEUTRALIZATION EPITOPES ON VP4 AND VP7 AFTER ROTAVIRUS INFECTION OR VACCINATION 査読

    K TANIGUCHI, T URASAWA, N KOBAYASHI, MU AHMED, N ADACHI, S CHIBA, S URASAWA

    JOURNAL OF CLINICAL MICROBIOLOGY   29 ( 3 )   483 - 487   1991年3月

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  • ANALYSIS OF THE NEWLY IDENTIFIED NEUTRALIZATION EPITOPES ON VP7 OF HUMAN ROTAVIRUS SEROTYPE-1 査読

    N KOBAYASHI, K TANIGUCHI, S URASAWA

    JOURNAL OF GENERAL VIROLOGY   72   117 - 124   1991年1月

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  • IDENTIFICATION OF OPERATIONALLY OVERLAPPING AND INDEPENDENT CROSS-REACTIVE NEUTRALIZATION REGIONS ON HUMAN ROTAVIRUS VP4 査読

    N KOBAYASHI, K TANIGUCHI, S URASAWA

    JOURNAL OF GENERAL VIROLOGY   71   2615 - 2623   1990年11月

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  • PRESUMPTIVE 7TH SEROTYPE OF HUMAN ROTAVIRUS

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    ARCHIVES OF VIROLOGY   113 ( 3-4 )   279 - 282   1990年

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  • SURVEY OF HUMAN ROTAVIRUS SEROTYPES IN DIFFERENT LOCALES IN JAPAN BY ENZYME-LINKED IMMUNOSORBENT-ASSAY WITH MONOCLONAL-ANTIBODIES

    S URASAWA, T URASAWA, K TANIGUCHI, F WAKASUGI, N KOBAYASHI, S CHIBA, N SAKURADA, M MORITA, O MORITA, M TOKIEDA, H KAWAMOTO, Y MINEKAWA, M OHSETO

    JOURNAL OF INFECTIOUS DISEASES   160 ( 1 )   44 - 51   1989年7月

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  • UNUSUAL HUMAN ROTAVIRUS STRAINS HAVING SUBGROUP-I SPECIFICITY AND LONG RNA ELECTROPHEROTYPE 査読

    N KOBAYASHI, IC LINTAG, T URASAWA, K TANIGUCHI, MC SANIEL, S URASAWA

    ARCHIVES OF VIROLOGY   109 ( 1-2 )   11 - 23   1989年

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  • Collaborative Research with Chinese, Indian, Filipino and North European Research Organizations on Infectious Disease Epidemics

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  • Epidemiology, Phylogeny, and Evolution of Emerging Enteric Picobirnaviruses of Animal Origin and Their Relationship to Human Strains

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  • Picobirnavirus infections: viral persistence and zoonotic potential

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  • Whole-genomic analysis of rotavirus strains: current status and future prospects

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    FUTURE MICROBIOLOGY   6 ( 9 )   1049 - 1065   2011年9月

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  • バングラデシュにおけるPVL陽性黄色ブドウ球菌の分布と遺伝子学的性状に関する解析

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  • Letters to the editor evidence for bovine origin of VP4 and VP7 genes of human group a rotavirus G6P[14] and G10P[14] strains

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  • ウイルス性感染性腸炎--ロタウイルス・ノロウイルス研究のあらたな展開 (第1土曜特集 ウイルス感染症--研究と臨床の最前線) -- (ウイルス感染症UPDATE)

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  • 日本の感染症サーベイランスデータの予測解析

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  • Prevalenee of Tetracycline Resistance Genes in Clinical Isolates of Enterococci in a Japanese Hospital

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  • Isolation and characterisation of poliovirus mutants resistant to heating at 50 degrees C for 30 min

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  • Dynamics of Infectious Diseases

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    Sapporo Medical Journal   72 ( 3-6 )   23 - 29   2003年12月

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  • Time series analysis of surveillance data of rotavirus infections in Japan

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  • Genetic analysis of a human Group B rotavirus detected recently in China

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  • Genetic analysis of a human group B rotavirus detected recently in China

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  • Prediction analysis for measles epidemics

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  • A new development of chaos analysis and a possibility of its application to epidemics of rotavirus infection

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    ウイルス感染症セミナー   2   33 - 41   2000年

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  • [Intracardiac floating thrombi in patients with acute pulmonary thromboembolism]

    J Cardiol   35   433 - 8   2000年

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  • ロタウイルス

    小林 宣道, 浦澤 正三

    ウイルス   50 ( 2 )   157 - 72   2000年

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    記述言語：日本語   出版者・発行元：日本ウイルス学会  

    その他リンク:： https://jlc.jst.go.jp/DN/JALC/00089819791?from=CiNii

    DOI： 10.2222/jsv.50.157

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  • 特集1：胃腸炎ウイルス 1. ロタウイルス

    小林 宣道, 浦澤 正三

    ウイルス   50 ( 2 )   157 - 172   2000年

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    記述言語：日本語   出版者・発行元：日本ウイルス学会  

    その他リンク:： https://jlc.jst.go.jp/DN/JALC/00089819791?from=CiNii

    DOI： 10.2222/jsv.50.157

    PubMed

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  • Distribution of insertion sequence-like element IS1272 and its position relative to methicillin resistance genes in clinically important staphylococci

    N Kobayashi, S Urasawa, N Uehara, N Watanabe

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   43 ( 11 )   2780 - 2782   1999年11月

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    記述言語：英語  

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  • Epidemiological study of the G serotype distribution of group a rotaviruses in Kenya from 1991 to 1994

    S Nakata, Z Gatheru, S Ukae, N Adachi, N Kobayashi, S Honma, J Muli, P Ogaja, J Nyangao, E Kiplagat, PM Tukei, S Chiba

    JOURNAL OF MEDICAL VIROLOGY   58 ( 3 )   296 - 303   1999年7月

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  • プロテインA遺伝子Xr領域の多様性に基づく黄色ブドウ球菌の分子疫学的解析

    小林 宣道, 浦沢 价子, 浦沢 正三

    日本衞生學雜誌   54 ( 1 )   349 - 349   1999年4月

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    記述言語：日本語  

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  • Analysis of genomic diversity within the Xr-region of the protein A gene in clinical isolates of Staphylococcus aureus

    N Kobayashi, S Urasawa, N Uehara, N Watanabe

    EPIDEMIOLOGY AND INFECTION   122 ( 2 )   241 - 249   1999年4月

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  • Analysis of human rotavirus G serotype in Bangladesh by enzyme-linked immunosorbent assay and polymerase chain reaction

    MU Ahmed, MM Alam, NS Chowdhury, MM Haque, N Shahid, N Kobayashi, K Taniguchi, T Urasawa, S Urasawa

    JOURNAL OF DIARRHOEAL DISEASES RESEARCH   17 ( 1 )   22 - 27   1999年3月

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    記述言語：英語  

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  • Analysis on reassortment of rotavirus NSP1 genes lacking coding region for cysteine-rich zinc finger motif

    J Okada, N Kobayashi, K Taniguchi, S Urasawa

    ARCHIVES OF VIROLOGY   144 ( 2 )   345 - 353   1999年

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  • Recent Research Developments in Antimicrobial Agents & Chemotherapy

    Research Signpost   3   153 - 163   1999年

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  • Genomic characteristics and reassortment of rotavirus RNA.

    Transworld Research Network   1   347 - 358   1999年

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  • Functional analysis of the heterologous NSP1 genes in the genetic background of simian rotavirus SA11 - Brief report

    J Okada, N Kobayashi, K Taniguchi, H Shiomi

    ARCHIVES OF VIROLOGY   144 ( 7 )   1439 - 1449   1999年

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  • Molecular discrimination of enterotoxin C subtype in clinical isolates of Staphylococcus aureus

    N Kobayashi, J Okada, K Kojima, S Urasawa, N Uehara, N Watanabe

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE   32 ( 3 )   243 - 246   1998年11月

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  • Analysis of diversity of mutations in the mecI gene and mecA promoter/operator region of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis

    N Kobayashi, K Taniguchi, S Urasawa

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   42 ( 3 )   717 - 720   1998年3月

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    記述言語：英語  

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  • 冬の食中毒−ウイルスによる食品媒介性胃腸炎について−

    Partnership   7   16 - 21   1998年

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  • 看護学生の風疹抗体保有状況_１３年間の連続調査−

    北海道公衆衛生誌   12   132 - 139   1998年

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  • 薬剤耐性菌の現状と問題点

    北海道公衆衛生誌   11   123 - 133   1997年

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  • [A clinical study on combination therapy of antimicrobial agents for complicated urinary tract infection--with special reference to combination with clarithromycin]

    Nippon Hinyokika Gakkai Zasshi.   88   596 - 604   1997年

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  • 複雑性尿路感染症に対する抗菌薬の併用療法の検討 -クラリスロマイシンを用いた併用療法について

    佐野 正人, 高橋 聡, 西村 昌宏, 広瀬 崇興, 熊本 悦明, 塚本 泰司, 小林 宣道

    日泌尿会誌   88 ( 6 )   596 - 604   1997年

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    記述言語：日本語   出版者・発行元：社団法人日本泌尿器科学会  

    (背景と目的) 我々は以前, 複雑性尿路感染症に対する検討で ciprofloxacin (CPFX), clarith-romycin (CAM) 併用投与群の方がCPFX単独投与よりも, 除菌率, 有効率とも高く, さらに1日投与量は400mgよりも600mgの方が治療効果が高まる可能性を報告した. そこで, 上記の結果を確認し, さらに尿路 biofilm に対する化学療法の確立を意図して臨床的検討を行った.<br>(方法) 複雑性尿路感染症に対して併用群ではCPFXとCAMを各々200mgを1日3回14日間, 単独群ではCPFX 200mg を1日3回14日間投与した.<br>(結果) 非留置例では14日目判定で除菌率が単独群30.0%, 併用群50.0%, UTI薬効評価基準にもとづく有効率は単独群61.5%, 併用群83.5%であった. 留置例では除菌率が単独群4.8%, 併用群19.0%, 有効率は単独群19.0%, 併用群42.9%であった. 起炎菌のMICが複雑性尿路感染症におけるCPFXのMIC breakpoint と考えられる25μg/ml以下の治療効果の検討では, 非留置例では除菌率が単独群45.5%, 併用群52.1%, 有効率は単独群77.7%, 併用群87.0%であった. 留置例では除菌率が単独群11.1%, 併用群18.2%, 有効率は単独群22.2%, 併用群50.0%であった. 留置例で治療後の走査電顕によるカテーテル表面の観察では, 単独群では biofilm の消失は認めなかったが, 併用群では75.0%の症例で biofilm の消失を認めた.<br>(結論) 以上より, 尿路 biofilm に対しCPFX, CAMの併用療法はある程度, 有効である可能性があるものと考えられた.

    その他リンク:： http://search.jamas.or.jp/link/ui/1997248219

    DOI： 10.5980/jpnjurol1989.88.596

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  • Superantigen as a modifying factor in HIV infection

    N Kobayashi, S Urasawa

    PEDIATRIC AIDS AND HIV INFECTION-FETUS TO ADOLESCENT   7 ( 3 )   143 - 154   1996年6月

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    記述言語：英語   掲載種別：書評論文，書評，文献紹介等  

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  • エピトープ

    KEY WORD 1997-98 感染症   1996年

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  • epitope

    KEY WORD 1997-98 Infectious Diseases   1996年

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  • Structure and function of rotavirus NSP1

    K Taniguchi, K Kojima, N Kobayashi, T Urasawa, S Urasawa

    ARCHIVES OF VIROLOGY   12   53 - 58   1996年

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    記述言語：英語  

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  • ロタウイルス

    小林 宣道, 浦沢 正三

    臨床とウイルス   23   179 - 183   1995年3月

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    記述言語：日本語  

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  • PREFERENTIAL SELECTION OF VP7 GENE FROM A PARENT ROTAVIRUS STRAIN (SA11) IN SEQUENTIAL PASSAGES AFTER MIXED INFECTION WITH SA11 AND SA11-HUMAN ROTAVIRUS SINGLE-VP7 GENE-SUBSTITUTION REASSORTANTS

    N KOBAYASHI, K TANIGUCHI, K KOJIMA, T URASAWA, S URASAWA

    ARCHIVES OF VIROLOGY   140 ( 4 )   775 - 781   1995年

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    記述言語：英語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

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  • DIFFERENCES IN PLAQUE SIZE AND VP4 SEQUENCE FOUND IN SA11 VIRUS CLONES HAVING SIMIAN AUTHENTIC VP4

    K TANIGUCHI, K NISHIKAWA, N KOBAYASHI, T URASAWA, HX WU, M GORZIGLIA, S URASAWA

    VIROLOGY   198 ( 1 )   325 - 330   1994年1月

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    記述言語：英語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

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  • NUCLEOTIDE-SEQUENCE OF VP4 AND VP7 GENES OF A UNIQUE HUMAN ROTAVIRUS STRAIN MC35 WITH SUBGROUP-I AND SEROTYPE-10 SPECIFICITY

    T URASAWA, K TANIGUCHI, N KOBAYASHI, K MISE, A HASEGAWA, Y YAMAZI, S URASAWA

    VIROLOGY   195 ( 2 )   766 - 771   1993年8月

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    記述言語：英語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

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  • PREPARATION AND CHARACTERIZATION OF A NEUTRALIZING MONOCLONAL-ANTIBODY DIRECTED TO VP4 OF ROTAVIRUS STRAIN K8 WHICH HAS UNIQUE VP4 NEUTRALIZATION EPITOPES

    N KOBAYASHI, K TANIGUCHI, T URASAWA, S URASAWA

    ARCHIVES OF VIROLOGY   121 ( 1-4 )   153 - 162   1991年

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    記述言語：英語  

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  • OPERATIONAL OVERLAPPING OF CROSS-REACTIVE AND SEROTYPE-SPECIFIC NEUTRALIZATION EPITOPES ON VP7 OF HUMAN ROTAVIRUS SEROTYPE-3

    N KOBAYASHI, K TANIGUCHI, S URASAWA

    ARCHIVES OF VIROLOGY   117 ( 1-2 )   73 - 84   1991年

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    記述言語：英語  

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  • ANTIGENIC AND GENETIC ANALYSES OF HUMAN ROTAVIRUS WITH DUAL SUBGROUP SPECIFICITY

    T URASAWA, K TANIGUCHI, N KOBAYASHI, F WAKASUGI, OISHI, I, Y MINEKAWA, M OSETO, MU AHMED, S URASAWA

    JOURNAL OF CLINICAL MICROBIOLOGY   28 ( 12 )   2837 - 2841   1990年12月

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    記述言語：英語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

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  • NUCLEOTIDE-SEQUENCE OF VP4-GENES AND VP7-GENES OF HUMAN ROTAVIRUSES WITH SUBGROUP-I SPECIFICITY AND LONG RNA PATTERN - IMPLICATION FOR NEW G-SEROTYPE SPECIFICITY

    K TANIGUCHI, T URASAWA, N KOBAYASHI, M GORZIGLIA, S URASAWA

    JOURNAL OF VIROLOGY   64 ( 11 )   5640 - 5644   1990年11月

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    記述言語：英語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

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  • CHARACTERIZATION BY ENZYME-LINKED IMMUNOSORBENT-ASSAY USING SUBGROUP-SPECIFIC AND SEROTYPE-SPECIFIC MONOCLONAL-ANTIBODIES OF HUMAN ROTAVIRUS OBTAINED FROM DIARRHEIC PATIENTS IN BANGLADESH

    MU AHMED, K TANIGUCHI, N KOBAYASHI, T URASAWA, F WAKASUGI, M ISLAM, H SHAIKH, S URASAWA

    JOURNAL OF CLINICAL MICROBIOLOGY   27 ( 7 )   1678 - 1681   1989年7月

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    記述言語：英語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

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  • ANTIGENIC CHARACTERIZATION OF ROTAVIRUSES ISOLATED IN KENYA FROM 1982 TO 1983

    T URASAWA, S URASAWA, Y CHIBA, K TANIGUCHI, N KOBAYASHI, LN MUTANDA, PM TUKEI

    JOURNAL OF CLINICAL MICROBIOLOGY   25 ( 10 )   1891 - 1896   1987年10月

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    記述言語：英語  

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▼全件表示

受賞

  • Heiwa Nakajima Foundation

    2003年  

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  • 平和中島財団国際学術研究助成

    2003年  

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共同研究・競争的資金等の研究課題

  • ウイルス感染症・細菌感染症の疫学・分子疫学、微生物薬剤耐性遺伝子の分子遺伝学、環境汚染化学物質の変異原性

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    資金種別：競争的資金

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