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  1986年

  札幌医科大学  

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  1986年

  札幌医科大学  

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• 博士（医学）

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  日本細菌学会

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  日本衛生学会

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  日本ウイルス学会

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  日本環境感染学会

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  日本化学療法学会

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• 札幌医科大学   医学部 医学科 衛生学講座 医学部医学科基礎医学部門講座衛生学講座   教授  

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• 衛生学

• ウイルス学

• 細菌学

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• Isolation and characterisation of poliovirus mutants resistant to heating at 50 degrees C for 30 min

  H Shiomi, T Urasawa, S Urasawa, N Kobayashi, S Abe, K Taniguchi

  JOURNAL OF MEDICAL VIROLOGY ( WILEY-LISS )  74 ( 3 ) 484 - 491  2004年11月

  　概要を見る

  Poliovirus is heat-labile; on heating at 50degreesC for 30 min its infectivity decreases drastically and its antigenicity reverts from N to H. However, mutants resistant to heating at 50degreesC for 30 min from the Sabin 1 and 2 viruses were isolated by repeating the process of incubation of the virus stock at 50degreesC for 30 min and multiplication of the remaining virus in a cell culture. The isolated mutants were stable genetically, and maintained the rct and d markers of the parent virus. On electron microscopical examination, the mutants were observed to retain the intact morphology after being heated at 50degreesC for 30 min, while the parent virus was converted to empty particles devoid of RNA under the same conditions. On determination of the nucleotide sequence of the P1 region, a single nucleotide sequence substitution was detected at nucleotide no. 2741, resulting in an amino acid change from valine to alanine at the 87th position of VP1. This amino acid might be associated with the heat-resistance of the mutants. Furthermore, it was found that the thermostable mutants obtained in this study, which are resistant to "high" temperature (50degreesC) for a short time (30 min), were not stable against heating at the ambient temperature (37degreesC) for a long time (5 or 7 days). This suggests that the inactivation at high temperature for a short time and that at ambient temperature for a long time involve different mechanisms. (C) 2004 Wiley-Liss, Inc.

  DOI

• Prediction analysis for measles epidemics

  A Sumi, N Ohtomo, Y Tanaka, S Sawamura, LF Olsen, N Kobayashi

  JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS ( INST PURE APPLIED PHYSICS )  42 ( 12 ) 7611 - 7620  2003年12月

  　概要を見る

  A newly devised procedure of prediction analysis, which is a linearized version of the nonlinear least squares method combined with the maximum entropy spectral analysis method, was proposed. This method was applied to time series data of measles case notification in several communities in the UK, USA and Denmark. The dominant spectral lines observed in each power spectral density (PSD) can be safely assigned as,fundamental periods. The optimum least squares fitting (LSF) curve calculated using these fundamental periods can essentially reproduce the underlying variation of the measles data. An extension of the LSF curve can be used to predict measles case notification quantitatively. Some discussions including a predictability of chaotic time series are presented.

  DOI CiNii

• Human group B rotavirus infections cause severe diarrhea in children and adults in Bangladesh

  T Sanekata, MU Ahmed, A Kader, K Taniguchi, N Kobayashi

  JOURNAL OF CLINICAL MICROBIOLOGY ( AMER SOC MICROBIOLOGY )  41 ( 5 ) 2187 - 2190  2003年05月

  　概要を見る

  Human group B rotavirus was detected in 12 of 220 adult patients and 2 of 67 child patients with severe diarrhea in Bangladesh. Group B rotavirus may be virulent in both adults and children, and the virus may be an especially serious diarrheal agent in Bangladesh.

  DOI

• Molecular characterization and epidemiology of group B rotaviruses.

  Diarrhoeal diseases - current status, research trends and field studies    2003年

• Analysis of non-structural protein NSP2 gene sequence and protein structure of human group B rotavirus strain WH-1

  Chin J Microbiol Immunol   23   853 - 857  2003年

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• Heiwa Nakajima Foundation

  2003年  

• 平和中島財団国際学術研究助成

  2003年  

共同研究・競争的資金等の研究課題 【 表示 ／ 非表示 】

共同研究・競争的資金等の研究課題 【 表示 ／ 非表示 】

• ウイルス感染症・細菌感染症の疫学・分子疫学、微生物薬剤耐性遺伝子の分子遺伝学、環境汚染化学物質の変異原性