2025/08/22 更新

写真a

カイ　マサヒロ
甲斐　正広
所属
医学部 生化学講座分子生物学分野 講師
職名
講師
外部リンク

学位

  • 博士（理学）

研究キーワード

  • 生化学

研究分野

  • ライフサイエンス / 分子生物学

学歴

  • 東京工業大学

    - 1993年

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    国名： 日本国

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  • 東京工業大学

    - 1993年

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所属学協会

論文

  • Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1. 査読 国際誌

    Nishiyama K, Maruyama R, Niinuma T, Kai M, Kitajima H, Toyota M, Hatanaka Y, Igarashi T, Kobayashi JI, Ogi K, Dehari H, Miyazaki A, Yorozu A, Yamamoto E, Idogawa M, Sasaki Y, Sugai T, Tokino T, Hiratsuka H, Suzuki H

    Cell death & disease   9 ( 8 )   826 - 826   2018年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41419-018-0893-2

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  • A Screen for Epigenetically Silenced microRNA Genes in Gastrointestinal Stromal Tumors. 査読 国際誌

    Isosaka M, Niinuma T, Nojima M, Kai M, Yamamoto E, Maruyama R, Nobuoka T, Nishida T, Kanda T, Taguchi T, Hasegawa T, Tokino T, Hirata K, Suzuki H, Shinomura Y

    PloS one   10 ( 7 )   e0133754   2015年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1371/journal.pone.0133754

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  • IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. 査読 国際誌

    Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JP, Shinomura Y, Tokino T, Toyota M

    Carcinogenesis   31 ( 3 )   342 - 9   2010年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/carcin/bgp179

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  • Diacylglycerol kinase η augments C-Raf activity and B-Raf/C-Raf heterodimerization 査読

    Yasuda, S, Kai, M, Imai, S, Takeishi, K. Taketomi, A, Toyota, M, Kanoh, H, Sakane, F

    J. Biol. Chem.   284 ( 43 )   29559 - 29570   2009年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1074/jbc.M109.043604

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  • Diacylglycerol kinase α enhances protein kinase Cζ-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-κB 査読

    Kai, M, Yasuda, S, Imai, S, Toyota, M, Kanoh, H, Sakane, F

    FEBS Lett.   583 ( 19 )   3265 - 3268   2009年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.febslet.2009.09.017

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  • Diacylglycerol kinase delta associates with receptor for activated C kinase 1, RACK1 査読

    Shin-ichi Imai, Satoshi Yasuda, Masahiro Kai, Hideo Kanoh, Fumio Sakane

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS   1791 ( 4 )   246 - 253   2009年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.bbalip.2009.01.024

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  • Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase γ with the Src homology 2 and C1 domains of β2-chimaerin. 査読

    Yasuda, S, Kai, M, Imai, S, Kanoh, H, Sakane, F

    Biochem. J.   409 ( 1 )   95 - 106   2008年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1042/BJ20070848

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  • Rab7 regulates maturation of melanosomal matrix protein gp100/Pmel17/Silv 査読

    Akinori Kawakami, Fumio Sakane, Shin-Ichi Imai, Satoshi Yasuda, Masahiro Kai, Hideo Kanoh, Hai-Ying Jin, Kuninori Hirosaki, Toshiharu Yamashita, David E. Fisher, Kowichi Jimbow

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   128 ( 1 )   143 - 150   2008年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/sj.jid.5700964

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  • Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity. 査読 国際誌

    Masahiro Kai, Satoshi Yasuda, Shin-Ichi Imai, Hideo Kanoh, Fumio Sakane

    Biochimica et biophysica acta   1773 ( 9 )   1407 - 15   2007年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    beta2-Chimaerin, an intracellular receptor for the second messenger diacylglycerol and phorbol esters, is a GTPase-activating protein (GAP) specific for Rac. beta2-Chimaerin negatively controls many Rac-dependent pathophysiological events including tumor development. However, the regulatory mechanism of beta2-chimaerin remains largely unknown. Here we report that beta2-chimaerin is tyrosine-phosphorylated by Src-family kinases (SFKs) upon cell stimulation with epidermal growth factor (EGF). Mutational analysis identified Tyr-21 in the N-terminal regulatory region as a major phosphorylation site. Intriguingly, the addition of SFK inhibitor and the replacement of Tyr-21 with Phe (Y21F) markedly enhanced Rac-GAP activity of beta2-chimaerin in EGF-treated cells. Moreover, the Y21F mutant inhibited integrin-dependent cell spreading, in which Rac1 plays a critical role, more strongly than wild-type beta2-chimaerin. These results suggest Tyr-21 phosphorylation as a novel, SFK-dependent mechanism that negatively regulates beta2-chimaerin Rac-GAP activity.

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  • Tyrosine phosphorylation of beta 2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity 査読

    Masahiro Kai, Satoshi Yasuda, Shin-ichi Imai, Hideo Kanoh, Fumio Sakane

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH   1773 ( 9 )   1407 - 1415   2007年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.bbamcr.2007.05.004

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  • Diacylglycerol kinases: why so many of them? 査読 国際誌

    Fumio Sakane, Shin-Ichi Imai, Masahiro Kai, Satoshi Yasuda, Hideo Kanoh

    Biochimica et biophysica acta   1771 ( 7 )   793 - 806   2007年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids, DAG and phosphatidic acid (PA), by phosphorylating DAG to yield PA. To date, ten mammalian DGK isozymes have been identified. In addition to the C1 domains (protein kinase C-like zinc finger structures) conserved commonly in all DGKs, these isoforms possess a variety of regulatory domains of known and/or predicted functions, such as a pair of EF-hand motifs, a pleckstrin homology domain, a sterile alpha motif domain and ankyrin repeats. Beyond our expectations, recent studies have revealed that DGK isozymes play pivotal roles in a wide variety of signal transduction pathways conducting development, neural and immune responses, cytoskeleton reorganization and carcinogenesis. Moreover, there has been rapidly growing evidence indicating that individual DGK isoforms exert their specific roles through interactions with unique partner proteins such as protein kinase Cs, Ras guanyl nucleotide-releasing protein, chimaerins and phosphatidylinositol-4-phosphate 5-kinase. Therefore, an emerging paradigm for DGK is that the individual DGK isoforms assembled in their own signaling complexes should carry out spatio-temporally segregated tasks for a wide range of biological processes via regulating local, but not global, concentrations of DAG and/or PA.

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  • Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation. 査読 国際誌

    Kenji Yanagisawa, Satoshi Yasuda, Masahiro Kai, Shin-ichi Imai, Keiko Yamada, Toshiharu Yamashita, Kowichi Jimbow, Hideo Kanoh, Fumio Sakane

    Biochimica et biophysica acta   1771 ( 4 )   462 - 74   2007年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We investigated the implication of diacylglycerol kinase (DGK) alpha (type I isoform) in melanoma cells because we found that this DGK isoform was expressed in several human melanoma cell lines but not in noncancerous melanocytes. Intriguingly, the overexpression of wild-type (WT) DGKalpha, but not of its kinase-dead (KD) mutant, markedly suppressed tumor necrosis factor (TNF)-alpha-induced apoptosis of AKI human melanoma cells. In the reverse experiment, siRNA-mediated knockdown of DGKalpha significantly enhanced the apoptosis. The overexpression of other type I isoforms (DGKbeta and DGKgamma) had, on the other hand, no detectable effects on the apoptosis. These results indicate that DGKalpha specifically suppresses the TNF-alpha-induced apoptosis through its catalytic action. We found that the overexpression of DGKalpha-WT, but not of DGKalpha-KD, further enhanced the TNF-alpha-stimulated transcriptional activity of an anti-apoptotic factor, NF-kappaB. Conversely, DGKalpha-knockdown considerably inhibited the NF-kappaB activity. Moreover, an NF-kappaB inhibitor blunted the anti-apoptotic effect of DGKalpha overexpression. Together, these results strongly suggest that DGKalpha is a novel positive regulator of NF-kappaB, which suppresses TNF-alpha-induced melanoma cell apoptosis.

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  • Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha- -induced apoptosis of human melanoma cells through NF-kappa B activation 査読

    Kenji Yanagisawa, Satoshi Yasuda, Masahiro Kai, Shin-ichi Imai, Keiko Yamada, Toshiharu Yamashita, Kowichi Jimbow, Hideo Kanoh, Fumio Sakane

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS   1771 ( 4 )   462 - 474   2007年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.bbalip.2006.12.008

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  • Diacylglycerol kinase γ interacts with and activates β2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor. 査読

    Yasuda, S, Kai, M, Imai, S, Kanoh, H, Sakane, F

    FEBS Lett.   581 ( 3 )   551 - 557   2007年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.febslet.2007.01.022

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  • Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts 査読

    Masahiro Kai, Fumio Sakane, Yan-Jun Jia, Shin-ichi Imai, Satoshi Yasuda, Hideo Kanoh

    JOURNAL OF BIOCHEMISTRY   140 ( 5 )   677 - 686   2006年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/jb/mvj195

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  • Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus. 査読 国際誌

    Takehiro Matsubara, Yasuhito Shirai, Kei Miyasaka, Takuya Murakami, Yasuto Yamaguchi, Takehiko Ueyama, Masahiro Kai, Fumio Sakane, Hideo Kanoh, Toshiaki Hashimoto, Shinji Kamada, Ushio Kikkawa, Naoaki Saito

    The Journal of biological chemistry   281 ( 10 )   6152 - 64   2006年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Diacylglycerol kinases (DGKs) convert diacylglycerol (DG) to phosphatidic acid, and both lipids are known to play important roles in lipid signal transduction. Thereby, DGKs are considered to be a one of the key players in lipid signaling, but its physiological function remains to be solved. In an effort to investigate one of nine subtypes, we found that DGKgamma came to be localized in the nucleus with time in all cell lines tested while seen only in the cytoplasm at the early stage of culture, indicating that DGKgamma is transported from the cytoplasm to the nucleus. The nuclear transportation of DGKgamma didn't necessarily need DGK activity, but its C1 domain was indispensable, suggesting that the C1 domain of DGKgamma acts as a nuclear transport signal. Furthermore, to address the function of DGKgamma in the nucleus, we produced stable cell lines of wild-type DGKgamma and mutants, including kinase negative, and investigated their cell size, growth rate, and cell cycle. The cells expressing the kinase-negative mutant of DGKgamma were larger in size and showed slower growth rate, and the S phase of the cells was extended. These findings implicate that nuclear DGKgamma regulates cell cycle.

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  • Identification and characterization of a novel human type II diacylglycerol kinase, DGKκ. 査読

    Imai, S, Kai, M, Yasuda, S, Kanoh, H, Sakane, F

    J. Biol. Chem.   280 ( 48 )   39870 - 39881   2005年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1074/jbc.M500669200

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MISC

  • 大腸がんにおけるdiacylglycerol kinase zeta遺伝子バリアントのエピジェネティックな制御

    甲斐 正広, 新沼 猛, 北嶋 洋志, 丸山 玲緒, 山本 英一郎, 鈴木 拓

    日本癌学会総会記事   75回   P - 1061   2016年10月

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    記述言語：英語   出版者・発行元：日本癌学会  

    医中誌

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  • 大腸がんのDNAメチル化異常におけるTET1関与の可能性(Possible role of TET1 dysregulation to induce aberrant DNA methylation in colorectal cancer)

    鈴木 拓, 丸山 玲緒, 津矢田 明泰, 新沼 猛, 山本 英一郎, 伊早坂 舞, 甲斐 正広, 篠村 恭久, 今井 浩三

    日本癌学会総会記事   73回   P - 1122   2014年9月

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    記述言語：英語   出版者・発行元：日本癌学会  

    医中誌

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  • DGKGは大腸がん細胞の増殖・浸潤・遊走をその酵素活性によらず抑制する(DGKG attenuates proliferation, invasion and migration of colorectal cancer cells independently of its enzymic activity)

    甲斐 正広, 山本 英一郎, 丸山 玲緒, 佐藤 亜紀子, 新沼 猛, 津矢田 明泰, 鈴木 拓

    日本癌学会総会記事   72回   341 - 341   2013年10月

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    記述言語：英語   出版者・発行元：日本癌学会  

    医中誌

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  • 悪性黒色腫の細胞浸潤におけるDGK-γの関与(DGK-gamma is involved in suppression of malignant melanoma cell invasion)

    佐藤 亜紀子, 甲斐 正広, 鈴木 拓, 山本 英一郎, 丸山 玲緒, 西坂 尚大, 山下 利春

    日本癌学会総会記事   71回   359 - 359   2012年8月

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    記述言語：英語   出版者・発行元：日本癌学会  

    医中誌

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  • Diacylglycerol kinases as emerging potential drug targets for a variety of diseases

    Fumio Sakane, Shin-ichi Imai, Masahiro Kai, Satoshi Yasuda, Hideo Kanoh

    CURRENT DRUG TARGETS   9 ( 8 )   626 - 640   2008年8月

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    記述言語：英語   掲載種別：書評論文，書評，文献紹介等  

    Web of Science

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  • Diacylglycerol kinases: Why so many of them?

    Fumio Sakane, Shin-ichi Imai, Masahiro Kai, Satoshi Yasuda, Hideo Kanoh

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS   1771 ( 7 )   793 - 806   2007年7月

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    記述言語：英語   掲載種別：書評論文，書評，文献紹介等  

    DOI： 10.1016/j.bbalip.2007.04.006

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  • ジアシルグリセロールキナーゼγは細胞刺激に応答し β2-chimaerin (Rac特異的GAP)を活性化する

    安田 智, 甲斐 正広, 今井 伸一, 坂根 郁夫, 加納 英雄

    脂質生化学研究   49   302 - 304   2007年6月

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    記述言語：日本語  

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  • β2-chimaerin のチロシンリン酸化によるRac特異的GAP活性の抑制

    甲斐 正広, 安田 智, 今井 伸一, 坂根 郁夫, 加納 英雄

    脂質生化学研究   49   312 - 315   2007年6月

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    記述言語：日本語  

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  • The plasma membrane translocation of diacylglycerol kinase delta 1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain

    S Imai, M Kai, K Yamada, H Kanoh, F Sakane

    BIOCHEMICAL JOURNAL   382 ( 3 )   957 - 966   2004年9月

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  • Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy

    S Miyamoto, M Hirata, A Yamazaki, T Kageyama, H Hasuwa, H Mizushima, Y Tanaka, H Yagi, K Sonoda, M Kai, H Kanoh, H Nakano, E Mekada

    CANCER RESEARCH   64 ( 16 )   5720 - 5727   2004年8月

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  • Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation

    S Tsushima, M Kai, K Yamada, S Imai, K Houkin, H Kanoh, F Sakane

    JOURNAL OF BIOLOGICAL CHEMISTRY   279 ( 27 )   28603 - 28613   2004年7月

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  • Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells

    YJ Jia, M Kai, Wada, I, F Sakane, H Kanoh

    FEBS LETTERS   552 ( 2-3 )   240 - 246   2003年9月

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  • Cell surface activities of the human type 2b phosphatidic acid phosphatase

    T Ishikawa, M Kai, Wada, I, H Kanoh

    JOURNAL OF BIOCHEMISTRY   127 ( 4 )   645 - 651   2000年4月

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  • Molecular characterization of the type 2 phosphatidic acid phosphatase

    H Kanoh, M Kai, Wada, I

    CHEMISTRY AND PHYSICS OF LIPIDS   98 ( 1-2 )   119 - 126   1999年4月

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  • ホスファチジン酸ホスファターゼ

    蛋白質・核酸・酵素   44   983 - 8   1999年

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  • [Phosphatidic acid phosphatase]

    Tanpakushitsu Kakusan Koso.   44   983 - 8   1999年

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  • Phosphatidic acid phosphatase (type 2), haloperoxidase family and germ cell migration

    Wada, I, M Kai, H Kanoh

    SEIKAGAKU   70 ( 9 )   1183 - 1188   1998年9月

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    記述言語：日本語   掲載種別：書評論文，書評，文献紹介等  

    Web of Science

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  • ホスファチジン酸ホスファターゼ２型とハロペルオキシダーゼファミリーと生殖細胞ガイダンス．

    生化学   70   1185 - 8   1998年

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  • Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase

    M Kai, Wada, I, S Imai, F Sakane, H Kanoh

    JOURNAL OF BIOLOGICAL CHEMISTRY   272 ( 39 )   24572 - 24578   1997年9月

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  • Promotion of transferrin folding by cyclic interactions with calnexin and calreticulin

    Wada, I, M Kai, S Imai, F Sakane, H Kanoh

    EMBO JOURNAL   16 ( 17 )   5420 - 5432   1997年9月

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  • Phosphatidic acid phosphatase from mammalian tissues: discovery of channel-like proteins with unexpected functions

    H Kanoh, M Kai, Wada, I

    BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM   1348 ( 1-2 )   56 - 62   1997年9月

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  • Translocation of diacylglycerol kinase alpha to the nuclear matrix of rat thymocytes and peripheral T-lymphocytes

    Wada, I, M Kai, S Imai, F Sakane, H Kanoh

    FEBS LETTERS   393 ( 1 )   48 - 52   1996年9月

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  • Molecular properties of enzymes involved in diacylglycerol and phosphatidate metabolism

    H Kanoh, M Kai, Wada, I

    JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING   14 ( 1-3 )   245 - 250   1996年9月

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  • Identification and cDNA cloning of 35-kDa phosphatidic acid phosphatase (Type 2) bound to plasma membranes - Polymerase chain reaction amplification of mouse H2O2-inducible hic53 clone yielded the cDNA encoding phosphatidic acid phosphatase

    M Kai, Wada, I, S Imai, F Sakane, H Kanoh

    JOURNAL OF BIOLOGICAL CHEMISTRY   271 ( 31 )   18931 - 18938   1996年8月

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  • Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those the EPH family of protein-tyrosine kinases

    F Sakane, S Imai, M Kai, Wada, I, H Kanoh

    JOURNAL OF BIOLOGICAL CHEMISTRY   271 ( 14 )   8394 - 8401   1996年4月

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  • The C-terminal part of diacylglycerol kinase alpha lacking zinc fingers serves as a catalytic domain.

    Biochem J   318   583 - 90   1996年

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  • LOCALIZATION OF THE GENE ENCODING DIACYLGLYCEROL-KINASE-3 (DAGK3) TO HUMAN-CHROMOSOME 3Q27-28 AND MOUSE CHROMOSOME-16

    J FITZGIBBON, D WELLS, A PILZ, J DELHANTY, M KAI, H KANOH, D HUNT

    CURRENT EYE RESEARCH   14 ( 11 )   1041 - 1043   1995年11月

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    記述言語：英語  

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  • CHAPERONE FUNCTION OF CALRETICULIN WHEN EXPRESSED IN THE ENDOPLASMIC-RETICULUM AS THE MEMBRANE-ANCHORED AND SOLUBLE FORMS

    WADA, I, S IMAI, M KAI, F SAKANE, H KANOH

    JOURNAL OF BIOLOGICAL CHEMISTRY   270 ( 35 )   20298 - 20304   1995年9月

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  • MOLECULAR-CLONING OF A DIACYLGLYCEROL KINASE ISOZYME PREDOMINANTLY EXPRESSED IN HUMAN RETINA WITH A TRUNCATED AND INACTIVE ENZYME EXPRESSION IN MOST OTHER HUMAN-CELLS

    M KAI, F SAKANE, S IMAI, WADA, I, H KANOH

    JOURNAL OF BIOLOGICAL CHEMISTRY   269 ( 28 )   18492 - 18498   1994年7月

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    記述言語：英語  

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共同研究・競争的資金等の研究課題

  • リン脂質代謝酵素の機能解析

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    資金種別：競争的資金

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