TAKAHASHI Hiroki

写真a

Affiliation

School of Medicine, Department of Rheumatology and Clinical Immunology

Job title

Professor
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Education 【 display / non-display 】

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    1989

    Sapporo Medical University  

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    1989

    Sapporo Medical University  

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Degree 【 display / non-display 】

  • M.D.(1985)、Ph.D(Medical Science 1989)

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Professional Memberships 【 display / non-display 】

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    日本臨床リウマチ学会

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    日本臨床血液学会

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    日本リウマチ学会

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    日本血液学会

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    日本内科学会

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   School of Medicine, 1st Dept.of Internal Medicine   Assistant Professor  

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Research Interests 【 display / non-display 】

  • 臨床免疫学 Immunology

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Misc 【 display / non-display 】

  • Clinical and pathological characteristics of Mikulicz's disease (IgG4-related plasmacytic exocrinopathy)

    M Yamamoto, H Takahashi, S Sugai, K Imai

    AUTOIMMUNITY REVIEWS ( ELSEVIER SCIENCE BV )  4 ( 4 ) 195 - 200  2005.04

    Book review, literature introduction, etc.  

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    Mikulicz's disease (MD) has been considered part of primary Sjogren's syndrome (SS) since Morgan's report in 1953. MD represents a unique condition involving enlargement of the lacrimal and salivary glands, as is also seen in SS, however, MD is characterized by few autoimmune reaction and its good responsiveness to glucocorticoid. Recent reports have shown that the frequency of apoptosis in glands of MD patients is lower when compared with SS. The phenomenon reflects the histologically reversible gland secretion in MD. Elevated IgG4 concentrations in the serum and prominent infiltration by plasmacytes expressing IgG4 in the lacrimal and salivary glands have also been confirmed in MD. Plasma cells expressing IgG4 are also detected in lymph nodes and bone marrow. MD may be a systemic disease, rather than a lacrimal and salivary gland disease. We here propose the new entity '' IgG4-related plasmacytic exocrinopathy '' and expect future development with regard to its relationship with autoimmune pancreatitis, which similarly presents elevated serum IgG4 levels. (c) 2004 Elsevier B.V. All rights reserved.

    DOI

  • Clinical and pathological differences between Mikulicz's disease and Sjogren's syndrome

    M Yamamoto, S Harada, M Ohara, C Suzuki, Y Naishiro, H Yamamoto, H Takahashi, K Imai

    RHEUMATOLOGY ( OXFORD UNIV PRESS )  44 ( 2 ) 227 - 234  2005.02

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    Objective. Mikulicz's disease (MD) has been included within the diagnosis of primary Sjogren's syndrome (SS), but represents a unique condition involving enlargement of the lachrymal and salivary glands and characterized by few autoimmune reactions and good responsiveness to glucocorticoids. We have previously described elevated immunoglobulin (Ig) G4 in the serum of four patients with MD. In this paper, we accumulated more MD cases and undertook clinical and histopathological analysis of these patients to clarify differences between MD and SS. Methods. We diagnosed seven patients with MD according to the following criteria: (i) visual confirmation of symmetrical and persistent swelling in more than two lachrymal and major salivary glands; (ii) prominent mononuclear infiltration of lachrymal and salivary glands; and (iii) exclusion of other diseases that present with glandular swelling, such as sarcoidosis and lymphoproliferative disease. We summarized the clinical and serological characteristics (IgG subclasses and IFN-gamma/IL-4 ratio) of seven patients with MD, compared with SS with glandular swelling (SSw) and without glandular swelling (SSo). After steroid administration, we analysed changes in IgG subclasses in MD. Labial salivary gland specimens in MD, SSw and SSo were stained with anti-IgG4 antibodies. Results. The concentration (+/-s.d.) of IgG4 was 1169.7 +/- 892.2 mg/dl in MD, 24.4 +/- 7.0 mg/dl in SSw (P<0.005) and 82.6 +/- 189.7 mg/dl in SSo (P<0.005). The IFN-gamma/IL-4 ratio was 0.392 +/- 0.083 (0.78 +/- 0.23/2.14 +/- 0.31 IU/pg) in MD, 0.004 +/- 0.002 (0.20 +/- 0.07/57.02 +/- 14.05 IU/pg) in SSw (P<0.05) and 0.012 +/- 0.009 (0.58 +/- 0.86/116.24 +/- 207.65 IU/pg) in SSo (P<0.05). The concentration (+/-s.d.) of IgG4 in MD decreased to 254.0 +/- 50.3 mg/dl (P<0.05) after glucocorticoid treatment. Histopathologically, only MD was associated with prominent infiltration of IgG4-positive plasmacytes into lachrymal and salivary glands. Conclusion. Mikulicz's disease is quite different from SS clinically and histopathologically. MD is suggested to be an IgG4-related systemic disease.

    DOI

  • [A case of scleroderma-polymyositis overlap syndrome in which octreotide exacerbated abdominal symptoms.]

    Nihon Rinsho Meneki Gakkai Kaishi   28   56 - 61  2005

  • Elevated IgG4 concentrations in serum of patients with Mikulicz's disease

    M Yamamoto, M Ohara, C Suzuki, Y Naishiro, H Yamamoto, H Takahashi, K Imai

    SCANDINAVIAN JOURNAL OF RHEUMATOLOGY ( TAYLOR & FRANCIS AS )  33 ( 6 ) 432 - 433  2004.11

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    Mikulicz's disease has recently been included within primary Sjogren's syndrome. It is a unique condition involving enlargement of the lacrimal and salivary glands, characterized by few autoimmune reactions. It is responsive to glucocorticoid treatment. Analysis of IgG fractions was performed in patients with Mikulicz's disease in order to determine the differences between Mikulicz's disease and Sjogren's syndrome. The study showed that serum IgG4 concentrations are elevated in patients with Mikulicz's disease, but not in those with Sjogren's syndrome.

    DOI

  • 新しい生物製剤を用いた難治性免疫疾患の治療 オーバービュー

    今井 浩三, 高橋 裕樹

    日本臨床免疫学会会誌   27 ( 1 ) 1 - 6  2004

    DOI PubMed

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Research Projects 【 display / non-display 】

  • モノクローナル抗体による自己免疫疾患の治療

  • 膠原病の消化管病変

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