HONMOU Osamu

写真a

Affiliation

Institute of Regenerative Medicine, Department of Neural Regenerative Medicine

Job title

Professor
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Education 【 display / non-display 】

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    1989

    Sapporo Medical University  

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    1989

    Sapporo Medical University  

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Degree 【 display / non-display 】

  • Ph.D.

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Professional Memberships 【 display / non-display 】

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    日本脳ドック学会

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    日本分子脳神経外科研究会

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    日本脳卒中学会

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    脳循環代謝学会

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    日本脳神経外科学会

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Research Areas 【 display / non-display 】

  • Life sciences   Neuroscience - general  

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   Department of Neural Regenerative Medicine, Research Institute of Regenerative Medicine   Professor  

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Research Interests 【 display / non-display 】

  • 脳神経外科学

  • 移植治療

  • 神経再生

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Papers 【 display / non-display 】

  • Intravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients

    Tomohiro Yamaki, Shinichi Oka, Satoshi Iyama, Masanori Sasaki, Rie Onodera, Yuko Kataoka-Sasaki, Takahiro Namioka, Ai Namioka, Masahito Nakazaki, Mitsuhiro Takemura, Ryo Ukai, Takahiro Yokoyama, Yuichi Sasaki, Tatsuro Yamashita, Masato Kobayashi, Misako Yamaguchi, Marina Fukino, Taro Takazawa, Megumi Hayasaka, Takamitsu Owaku, Mika Funakura, Shinji Onodera, Yoichi M. Ito, Masayoshi Kobune, Junji Kato, Sumio Ishiai, Jeffery D. Kocsis, Masaru Odaki, Yasuo Iwadate, Shigeki Kobayashi, Osamu Honmou

    Interdisciplinary Neurosurgery: Advanced Techniques and Case Management   36  2024.06

    DOI

  • 最新基礎科学/知っておきたい 骨髄間葉系幹細胞を用いた脊髄損傷治療の基礎と臨床

    廣田 亮介, 佐々木 祐典, 本望 修, 山下 敏彦

    臨床整形外科 ( 株式会社医学書院 )  59 ( 3 ) 308 - 311  2024.03

    DOI

  • 頭部外傷後遺症に対する骨髄間葉系幹細胞投与後アミノ酸PETによる脳代謝変化の描出

    八巻 智洋, 岡 真一, 岡 信男, 佐々木 祐典, 本望 修, 小林 繁樹

    核医学 ( (一社)日本核医学会 )  61 ( Suppl. ) S153 - S153  2024

  • Repeated intravenous infusion of mesenchymal stem cells enhances recovery of motor function in a rat model with chronic spinal cord injury.

    Kota Kurihara, Masanori Sasaki, Hiroshi Nagahama, Hisashi Obara, Ryunosuke Fukushi, Ryosuke Hirota, Mitsunori Yoshimoto, Atsushi Teramoto, Jeffery D Kocsis, Toshihiko Yamashita, Osamu Honmou

    Brain research   1817   148484 - 148484  2023.10  [International journal]

    　View Summary

    Spinal cord injury (SCI) can cause paralysis with a high disease burden with limited treatment options. A single intravenous infusion of mesenchymal stem cells (MSCs) improves motor function in rat SCI models, possibly through the induction of axonal sprouting and remyelination. Repeated infusions (thrice at weekly intervals) of MSCs were administered to rats with chronic SCI to determine if multiple-dosing regimens enhance motor improvement. Chronic SCI rats were randomized and infused with vehicle (vehicle), single MSC injection at week 6 (MSC-1) or repeatedly injections of MSCs at 6, 7, and 8 weeks (MSC-3) after SCI induction. In addition, a single high dose of MSCs (HD-MSC) equivalent to thrice the single dose was infused at week 6. Locomotor function, light and electron microscopy, immunohistochemistry and ex vivo diffusion tensor imaging were performed. Repeated infusion of MSCs (MSC-3) provided the greatest functional recovery compared to single and single high-dose infusions. The density of remyelinated axons in the injured spinal cord was the greatest in the MSC-3 group, followed by the MSC-1, HD-MSC and vehicle groups. Increased sprouting of the corticospinal tract and serotonergic axon density was the greatest in the MSC-3 group, followed by MSC-1, HD-MSC, and vehicle groups. Repeated infusion of MSCs over three weeks resulted in greater functional improvement than single administration of MSCs, even when the number of infused cells was tripled. MSC-treated rats showed axonal sprouting and remyelination in the chronic phase of SCI.

    DOI PubMed

  • Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury.

    Kojiro Terada, Masanori Sasaki, Hiroshi Nagahama, Yuko Kataoka-Sasaki, Shinichi Oka, Ryo Ukai, Takahiro Yokoyama, Yusuke Iizuka, Takuro Sakai, Shinobu Fukumura, Takeshi Tsugawa, Jeffery D Kocsis, Osamu Honmou

    Pediatric research    2023.07  [International journal]

    　View Summary

    BACKGROUND: Perinatal brain injury is multifactorial and primarily associated with brain prematurity, inflammation, and hypoxia-ischemia. Although recent advances in perinatal medicine have improved the survival rates of preterm infants, neurodevelopmental disorders remain a significant complication. We tested whether the intravenous infusion of mesenchymal stem cells (MSCs) had therapeutic efficacy against perinatal brain injury in rats. METHODS: Pregnant rats at embryonic day (E) 18 received lipopolysaccharide and the pups were born at E21. On postnatal day (PND) 7, the left common carotid artery of each pup was ligated, and they were exposed to 8% oxygen for 2 h. They were randomized on PND10, and MSCs or vehicle were intravenously infused. We performed behavioral assessments, measured brain volume using MRI, and performed histological analyses on PND49. RESULTS: Infused MSCs showed functional improvements in our model. In vivo MRI revealed that MSC infusion increased non-ischemic brain volume compared to the vehicle group. Histological analyses showed that cortical thickness, the number of NeuN+ and GAD67+ cells, and synaptophysin density in the non-ischemic hemisphere in the MSC group were greater than the vehicle group, but less than the control group. CONCLUSIONS: Infused MSCs improve sensorimotor and cognitive functions in perinatal brain injury and enhance neuronal growth. IMPACT: Intravenous infusion of MSCs improved neurological function in rats with perinatal brain injury, including motor, sensorimotor, cognitive, spatial, and learning memory. Infused MSCs increased residual (non-ischemic) tissue volume, number of neuronal cells, GABAergic cells, and cortical synapses in the contralesional (right) hemisphere. Intravenous administration of MSC might be suitable for the treatment of perinatal brain injury.

    DOI PubMed

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Misc 【 display / non-display 】

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Awards 【 display / non-display 】

  • 北海道科学技術賞

    2020  

  • 北海道新聞文化賞

    2019  

  • 日本医師会医学研究奨励賞

    2013  

  • 日本再生医療学会 感謝状

    2002  

  • 日本分子脳神経外科研究会 感謝状

    2001  

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Research Projects 【 display / non-display 】

  • 慢性期脳梗塞に対する骨髄幹細胞治療における至適リハビリ条件の探索

    基盤研究(C)

    Project Year :

    2024.04
    -
    2027.03
     

    山下 達郎, 佐々木 雄一, 佐々木 祐典, 鵜飼 亮, 岡 真一, 佐々木 優子, 本望 修, 中崎 公仁

  • 神経障害性疼痛・脊髄障害性疼痛に対する間葉系幹細胞の治療メカニズムの解析

    基盤研究(C)

    Project Year :

    2024.04
    -
    2027.03
     

    福士 龍之介, 佐々木 祐典, 小原 尚, 廣田 亮介, 佐々木 優子, 山下 敏彦, 本望 修

  • 脳梗塞に対する骨髄幹細胞治療による神経回路の再構築の革新的MRIによる統合的解析

    基盤研究(C)

    Project Year :

    2024.04
    -
    2027.03
     

    長濱 宏史, 佐々木 祐典, 本望 修, 中崎 公仁

  • Therapeutic strategies for cerebral infarction and spinal cord injury by activating plasticity throughout the central nervous system

    Grant-in-Aid for Scientific Research (B)

    Project Year :

    2024.04
    -
    2025.03
     

    本望 修, 佐々木 雄一, 福士 龍之介, 佐々木 祐典, 小原 尚, 鵜飼 亮, 小林 萬里, 山下 達郎, 横山 貴裕, 岡 真一, 佐々木 優子, 中崎 公仁

  • Bone marrow mesenchymal stem cell transplantation prevents concurrent progression of chronic kidney disease and associated cerebrovascular disease

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2023.04
    -
    2026.03
     

    長岡 由修, 飯塚 裕典, 寺田 光次郎, 津川 毅, 佐々木 祐典, 本望 修

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