YAMAKAGE Michiaki

写真a

Affiliation

School of Medicine, Department of Anesthesiology

Job title

Professor
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Education 【 display / non-display 】

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    1993

    Sapporo Medical University Postgraduate School of Medicine  

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    1988

    Sapporo Medical University School of Medicine  

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Degree 【 display / non-display 】

  • Ph.D. (Medical)

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Professional Memberships 【 display / non-display 】

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    Japanese Society of Dental Anesthesia

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    日本手術医学会

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    日本循環制御医学会

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    Japan Medical Association

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    International Anesthesia and Research Society

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Research Areas 【 display / non-display 】

  • Life sciences   Anesthesiology  

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   医学部 医学科学科目（臨床医学部門）   教授  

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Research Interests 【 display / non-display 】

  • 呼吸 吸入麻酔薬 血液凝固線溶 体温管理 統計 医学教育

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Papers 【 display / non-display 】

  • Differences in circulating blood volume changes during emergence from general anesthesia in transcatheter aortic valve implantation and MitraClip implantation.

    Makishi Maeda, Yusuke Yoshikawa, Sho Ohno, Tomohiro Chaki, Michiaki Yamakage

    Journal of anesthesia   38 ( 4 ) 489 - 495  2024.08  [Domestic journal]

    　View Summary

    PURPOSE: We aimed to compare changes in the circulating blood volume (CBV) during emergence from general anesthesia in patients undergoing transcatheter aortic valve implantation (TAVI) and MitraClip implantation. METHOD: We included 97 patients who underwent TAVI or MitraClip implantation. The primary outcome was the rate of change in the estimated CBV associated with emergence from general anesthesia. The secondary outcomes were hemoglobin and hematocrit values before and after emergence from anesthesia for each procedure. Additionally, the independent factors associated with changes in the estimated CBV were assessed using multiple regression analysis. RESULTS: In the TAVI group, the hemoglobin concentration increased from 9.6 g/dL before emergence from anesthesia to 10.8 g/dL after emergence (P < 0.001; mean difference, 1.2 g/dL, 95% confidence interval [CI] 1.1-1.3 g/dL). Conversely, no statistically significant change was observed in the hemoglobin concentration before and after emergence from anesthesia in the MitraClip group. The mean rate of change in the estimated CBV was - 15.4% (standard deviation [SD] 6.4%) in the TAVI group and - 2.4% (SD, 4.7%) in the MitraClip group, indicating a significant decrease in the estimated CBV in the former than in the latter (P < 0.001; mean difference, 13.0%; 95% CI 9.9-16.1%). CONCLUSION: Emergence from general anesthesia increased the hemoglobin concentration and decreased the estimated CBV in patients undergoing TAVI but did not elicit significant changes in patients undergoing MitraClip implantation. These results may provide a rationale for minimizing blood transfusions during general anesthesia in patients undergoing these procedures.

    DOI PubMed

  • INJEX50 could improve the success rate of local anesthesia for arterial cannulation in the pediatric intensive care unit: A randomized, double-blind, single-center study.

    Wataru Sakai, Tomohiro Chaki, Shunsuke Tachibana, Yuki Ichisaka, Yuko Nawa, Tomohiro Nawa, Michiaki Yamakage

    Paediatric anaesthesia    2024.05  [International journal]

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    BACKGROUND: Quick arterial cannulation is required in pediatric emergency situation, which require effective local anesthesia to avoid withdrawal movement. However, pediatric local anesthesia could be difficult because of withdrawal movement. Jet injectors, which are needleless and provide local anesthesia quickly, could be helpful for pediatric local anesthesia during arterial cannulation. AIMS: This study aimed to examine whether new jet injector "INJEX50" could improve the success rate of local anesthesia for arterial cannulation in pediatric intensive care unit compared with the current standard of care, infiltration using a 26-gauge needle. METHODS: This study was a randomized, double-blind, single-center study. Participants were infants and young children in the pediatric intensive care unit, who required an arterial line. Local anesthesia was performed with either a 26-gauge needle (group C) or INJEX50 (group I) before arterial cannulation. The primary outcome (success of local anesthesia) was the presence of withdrawal movement at the time of skin puncture for arterial cannulation. The secondary outcomes included rescue sedation during arterial cannulation. Data were analyzed using Fisher's exact test and the Mann-Whitney U-test, with values of p < .05 considered statistically significant. RESULTS: Seventy patients were randomly assigned to groups C and I. The local anesthesia success rate in group I (30/35 [86%]) was significantly higher than that in group C (15/35 [43%], odds ratio, 8.00; 95% confidence interval, 2.51-25.5; p = .0005). In conclusion, INJEX50 could improve success rate of local anesthesia for arterial cannulation in pediatric intensive care unit compared with 26-gauge needle.

    DOI PubMed

  • Effect of using hypotension prediction index versus conventional goal-directed haemodynamic management to reduce intraoperative hypotension in non-cardiac surgery: A randomised controlled trial.

    Yusuke Yoshikawa, Makishi Maeda, Tatsuya Kunigo, Tomoe Sato, Kanako Takahashi, Sho Ohno, Tomoki Hirahata, Michiaki Yamakage

    Journal of clinical anesthesia   93   111348 - 111348  2024.05  [International journal]

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    STUDY OBJECTIVE: It remains unclear whether it is the hypotension prediction index itself or goal-directed haemodynamic therapy that mitigates intraoperative hypotension. DESIGN: A single centre randomised controlled trial. SETTING: Sapporo Medical University Hospital. PATIENTS: A total of 64 adults patients undergoing major non-cardiac surgery under general anaesthesia. INTERVENTIONS: Patients were randomly assigned to either group receiving conventional goal-directed therapy (FloTrac group) or combination of the hypotension prediction index and conventional goal-directed therapy (HPI group). To investigate the independent utility of the index, the peak rates of arterial pressure and dynamic arterial elastance were not included in the treatment algorithm for the HPI group. MEASUREMENTS: The primary outcome was the time-weighted average of the areas under the threshold. Secondary outcomes were area under the threshold, the number of hypotension events, total duration of hypotension events, mean mean arterial pressure during the hypotension period, number of hypotension events with mean arterial pressure < 50 mmHg, amounts of fluids, blood products, blood loss, and urine output, frequency and amount of vasoactive agents, concentration of haemoglobin during the monitoring period, and 30-day mortality. MAIN RESULTS: The time-weighted average of the area below the threshold was lower in the HPI group than in the control group; 0.19 mmHg (interquartile range, 0.06-0.80 mmHg) vs. 0.66 mmHg (0.28-1.67 mmHg), with a median difference of -0.41 mmHg (95% confidence interval, -0.69 to -0.10 mmHg), p = 0.005. Norepinephrine was administered to 12 (40%) and 5 (17%) patients in the HPI and FloTrac groups, respectively (p = 0.045). No significant differences were observed in the volumes of fluid and blood products between the study groups. CONCLUSIONS: The current randomised controlled trial results suggest that using the hypotension prediction index independently lowered the cumulative amount of intraoperative hypotension during major non-cardiac surgery.

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  • Comparison of the negative effect of remimazolam and propofol on cardiac contractility: Analysis of a randomised parallel-group trial and a preclinical ex vivo study.

    Yusuke Yoshikawa, Shunsuke Oura, Masatoshi Kanda, Tomohiro Chaki, Naoyuki Hirata, Mitsutaka Edanaga, Michiaki Yamakage

    Clinical and experimental pharmacology & physiology   51 ( 3 ) e13840  2024.03  [International journal]

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    Remimazolam is a newly developed ultra-short-acting benzodiazepine that exerts sedative effects. This study aimed to clarify the effects of remimazolam on cardiac contractility. In a randomised-parallel group trial, haemodynamic parameters were compared between propofol (n = 11) and remimazolam (n = 12) groups during the induction of general anaesthesia in patients undergoing non-cardiac surgery. In a preclinical study, the direct effects of remimazolam on cardiac contractility were also evaluated using isolated rat hearts. RNA sequence data obtained from rat and human hearts were analysed to assess the expression patterns of the cardiac γ-aminobutyric acid type A (GABAA ) receptor subunits. In a clinical study, the proportional change of the maximum rate of arterial pressure rise was milder during the study period in the remimazolam group (propofol: -52.6 [10.2] (mean [standard deviation])% vs. remimazolam: -39.7% [10.5%], p = 0.007). In a preclinical study, remimazolam did not exert a negative effect on left ventricle developed pressure, whereas propofol did exert a negative effect after bolus administration of a high dose (propofol: -26.9% [3.5%] vs. remimazolam: -1.1 [6.9%], p < 0.001). Analysis of the RNA sequence revealed a lack of γ subunits, which are part of the major benzodiazepine binding site of the GABAA receptor, in rat and human hearts. These results indicate that remimazolam does not have a direct negative effect on cardiac contractility, which might contribute to its milder effect on cardiac contractility during the induction of general anaesthesia. The expression patterns of cardiac GABAA receptor subunits might be associated with the unique pharmacokinetics of benzodiazepines in the heart.

    DOI PubMed

  • Japanese Traditional Herbal Medicine, Rikkunshito, Partially Suppresses Inflammatory Responses in Myocardial Ischemia/Reperfusion Injury.

    Tomoe Sato, Yasuaki Sawashita, Yusuke Yoshikawa, Michiaki Yamakage

    Cureus   16 ( 2 ) e54485  2024.02  [International journal]

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    INTRODUCTION: Myocardial ischemia/reperfusion (I/R) injury can cause additional damage to an ischemic myocardium, even after successful reperfusion therapy. Inflammation is a mechanism that exacerbates myocardial damage after I/R injury. Rikkunshito (RKT) is a traditional Japanese herbal medicine widely used to treat gastrointestinal symptoms. It attenuates inflammation and fibrosis in some diseases of the heart; however, it remains unclear whether RKT exerts cardioprotective effects against myocardial I/R injury. To elucidate this, we evaluated the effects of RKT pre-treatment by oral administration on the myocardium in a mouse model of in vivo I/R injury. METHODS: Mice were randomly assigned to a group receiving distilled water (DW) or one receiving RKT (1000 mg/kg/day) for 14 days orally. For each of the RKT and DW groups, a sham group, an I/R 2 h group, and an I/R 24 h group were created. On day 15, myocardial I/R surgery was performed. The left anterior descending coronary artery (LAD) was ligated for 30 min, and reperfusion time was set at 2 h or 24 h. The myocardial infarct size (IS) was measured after 2 h of reperfusion, and cardiac cytokine mRNA expression levels were evaluated by quantitative reverse transcription polymerase chain reaction (RT-PCR) after 2 h and 24 h of reperfusion. RESULTS: RKT pre-treatment significantly suppressed the cardiac mRNA expression level of interleukin-1β in the RKT-I/R 2 h group compared to the DW-I/R 2 h group (P < 0.05). Additionally, RKT significantly suppressed the mRNA expression levels of transforming growth factor-β compared to DW; the same result was obtained for the expression levels of interleukin-6. However, RKT did not reduce the IS or mRNA expression levels of the cardiac congestive markers natriuretic peptide a (NPPA) and natriuretic peptide b (NPPB). In addition, RKT did not alter the plasma concentration of ghrelin and sirtuin 1 (Sirt1), which have been reported to be stimulated by RKT. CONCLUSION: This study showed that pre-treatment of RKT for myocardial I/R injury partially suppressed inflammation-related cytokines. However, further studies are needed on the effect of RKT on the reduction of myocardial infarction size.

    DOI PubMed

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Misc 【 display / non-display 】

  • Blocking of the saphenous and obturator nerves using a pectineus muscle plane block

    Hironobu Ueshima, Atsushi Sawada, Michiaki Yamakage, Mineko Fujimiya

    Journal of Clinical Anesthesia ( Elsevier Inc. )  60   2 - 3  2020.03

    Rapid communication, short report, research note, etc. (scientific journal)  

    DOI PubMed

  • 遠隔虚血プレコンディショニングは非アシル化グレリンの分泌によってJAK2/STAT3経路が活性化し心臓虚血再灌流傷害を減弱させる

    澤下泰明, 平田直之, 吉川裕介, 寺田拡文, 山蔭道明

    日本麻酔科学会学術集会(Web)   67th  2020

    J-GLOBAL

  • 妊娠高血圧症を合併した多発性硬化症の妊婦に硬膜外麻酔のみで帝王切開を施行した1症例

    佐藤優真, 君塚基修, 吉川裕介, 枝長充隆, 山蔭道明

    日本臨床麻酔学会誌   38 ( 6 )  2018

    J-GLOBAL

  • Sonoclotで無輸血手術が可能となった血小板増加症を合併した大動脈弁輪拡張症の1症例

    畠山陽介, 枝長充隆, 吉川裕介, 松本友美, 寺田拡文, 木井菜摘, 山蔭道明

    Cardiovascular Anesthesia   22 ( Suppl )  2018

    J-GLOBAL

  • Anesthetic Management with Percutaneous Cardiopulmonary Support for Emergency Tracheotomy in a Patient with a Thyroid Tumor who Had Severe Tracheal Stenosis from Thyroid Tumor

    横山竜也, 新山幸俊, 吉川裕介, 高田幸昌, 山蔭道明

    麻酔   67 ( 11 )  2018

    J-GLOBAL

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Awards 【 display / non-display 】

  • Takahashi Prize of Hokkaido Society of Anesthesiologiists

    2003  

  • 北海道麻酔科学会 第16回高橋賞

    2003  

  • Yamamura Memorial Prize, Japan Society of Anesthesiologists

    2002  

  • 日本麻酔科学会 第21回山村記念賞

    2002  

  • The Uehara Memorial Foundation, Incentive Grant

    2000  

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Research Projects 【 display / non-display 】

  • 低親和性神経成長因子受容体選択的リガンド：LM11A-31による術後認知機能障害予防戦略

    基盤研究(C)

    Project Year :

    2023.04
    -
    2026.03
     

    山蔭 道明, 平畑 知輝, 茶木 友浩, 佐藤 慧

  • 人工呼吸器関連肺障害における肺血管内皮グリコカリックスの動態と新たな治療法の探索

    基盤研究(C)

    Project Year :

    2022.04
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    2025.03
     

    菊池 謙一郎, 数馬 聡, 山蔭 道明

  • Prevention strategies for perioperative neuroinflammation related diseases with a focus on stabilization of intestinal microbiota

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2019.04
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    2022.03
     

    Yamakage Michiaki

    　View Summary

    In a metagenomic analysis of cecal contents collected under anesthesia after surgical intervention, we were unable to explore significant changes between the groups. It was suggested that the timeline of intervention and other factors need to be re-examined. While the composition of the cecal contents was not acutely altered, we did find changes in delirium behavior in the surgical group, with no significant differences between groups. Additional experiments are planned.
    Translated with www.DeepL.com/Translator (free version)

  • Analysis of a relationship between postoperative delirium or/and cognitive dysfunction and aging by transcriptome analysis

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2016.04
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    2019.03
     

    Yamakage Michiaki, TACHIBANA SHUNSUKE

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    Transcriptome analysis revealed that age differences resulted in significant changes in gene expression in the hippocampus after anesthesia and surgery. In other words, it was suggested that metabolisms and reactivities in the brain cause differences in responses due to aging. In addition, the sensitivity of anesthetics due to aging and the immune response to surgical insult are different, and the possibility of clarifying the mechanism of influences and differences in brain function was shown.

  • Living with chronic non-cancer pain receiving opioid therapy

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2015.04
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    2019.03
     

    SHINDO Yukari, Yamakage Michiaki, Watanabe Akihiko

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    Narratives of daily life of outpatients in Japan receiving opioid therapy for chronic non-cancer pain were obtained to identify health problems and barriers to obtaining a high quality of life. Participants were 34 adult volunteer outpatients treated in pain clinics. Data were collected using semi-structured interviews and analyzed through grounded theory. Participants described daily life experiences of chronic pain and opioid therapy. Informed consent and ethical approval were obtained. Six categories were extracted: “Facing injustice or extreme chronic pain and catastrophizing,” “Attempting treatments to improve the condition,” “Ambivalent about receiving medical treatment,” “Barriers to living with chronic pain,” “Finding a compromise while living with chronic pain,” and “Regaining a life.” These findings expand our understanding of Japanese patients received opioid treatment with chronic non-cancer pain and their coping in daily life.

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