成松　英智 (ナリマツ　エイチ)

写真a

所属

医学部 救急医学講座

職名

教授
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学歴 【 表示 ／ 非表示 】

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    1992年

    札幌医科大学  

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    1992年

    札幌医科大学  

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    1987年

    札幌医科大学  

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    1987年

    札幌医科大学  

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学位 【 表示 ／ 非表示 】

  • 医学士

  • 博士（医学）

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所属学協会 【 表示 ／ 非表示 】

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    日本生理学会

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    Japan Society of Intensive Care Medicine

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    日本集中治療学会

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    日本麻酔学会

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    Japanese Society of Anesthesiologists

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researchmapの所属 【 表示 ／ 非表示 】

  • 札幌医科大学   附属病院 救急集中治療部 附属病院救急集中治療部救急集中治療部   助教授  

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研究キーワード 【 表示 ／ 非表示 】

  • 救急医学 集中治療学 麻酔学 神経生理学

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  • A paratracheal cystic lesion in a patient with potential high-energy trauma

    E Narimatsu, N Yama, W Danjoh, Y Kurimoto, Y Asai

    JOURNAL OF EMERGENCY MEDICINE ( ELSEVIER SCIENCE INC )  28 ( 3 ) 333 - 335  2005年04月

    DOI

  • Changes in response properties and receptive fields of spinal dorsal horn neurons in rats after surgical incision in hairy skin

    M Kawamata, M Koshizaki, SG Shimada, E Narimatsu, Y Kozuka, T Takahashi, A Namiki, JG Collins

    ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS )  102 ( 1 ) 141 - 151  2005年01月

    　概要を見る

    Background: Mechanical hyperalgesia and allodynia associated with chemical irritant application are mediated by spinal high-threshold (HT) as well as wide-dynamic-range neurons as a result of "central sensitization." Because the pathophysiology of pain is thought to differ depending on the type of injury and may vary between hairy and glabrous skin, the authors examined changes in properties of spinal dorsal horn neurons after surgical incisions in hairy skin of rats to obtain insights into the mechanisms of postoperative pain. Methods: Withdrawal responses to punctate mechanical stimulation and gentle brushing were measured in awake rats In an area adjacent to the injured site (primary area) and in an area 2 cm from the injured site (secondary area) after 1-cm longitudinal incisions through the hairy skin, fascia, and muscle had been made in the hindquarters. In a separate study, responses of spinal wide-dynamic-range, HT, and low-threshold neurons to nonnoxious and noxious stimuli were recorded before and after similar incisions had been made in the centers of their receptive fields. Effects of spinal application of the gamma-aminobutyric acid A receptor antagonist bicuculline (15 mug) on responses of HT neurons were then studied. Results: Awake rats showed primary and secondary hyperalgesia to punctate mechanical stimulation 30 min after the incision and thereafter for 4 days and 1 day, respectively. Mechanical allodynia associated with brush stimulation was only seen in the primary area 30 min after the incision and thereafter for 1 day. The incision resulted in increases in activity of wide-dynamic-range neurons (receptive field sizes and responses to both innocuous and noxious stimuli). HT neurons did not respond to innocuous stimulation and showed very small increases or no changes in receptive field size and responses to noxious stimuli after the incision. However, the majority of HT neurons began to respond to innocuous stimuli after application of bicuculline (15 mug/50 mul) to the spinal cord. Conclusions: The results suggest that wide-dynamic-range neurons are responsible for behavioral hyperexcitability after surgical incision but that HT neurons are not involved in the hyperexcitability, despite the fact that HT neurons arc capable of responding to innocuous stimuli by reversal of gamma-aminobutyric acid-mediated inhibition.

    DOI

  • Effects of halothane and isoflurane on hyperexcitability of spinal dorsal horn neurons after incision in the rat

    M Kawamata, E Narimatsu, Y Kozuka, T Takahashi, S Sugino, T Niiya, A Namiki

    ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS )  102 ( 1 ) 165 - 174  2005年01月

    　概要を見る

    Background: The aim of this study was to determine whether halothane and isoflurane used during and after surgical injury attenuate subsequent hyperexcitability of spinal dorsal horn (SDH) neurons by preventing development of central sensitization. Methods: Activity of a wide-dynamic-range neuron of the SDH was isolated in decerebrate-spinal Sprague-Dawley rats, and neuronal activity (receptive field size and responses to non-noxious and noxious stimuli) was recorded. A 1-cm-long incision was made through the skin, fascia, and muscle under anesthesia with halothane (1.1% or 2.2%) and isoflurane (1.4% or 2.8%). Anesthesia was discontinued just after the incision had been made or was continued until 30 min after the incision, and activity of the SDH neurons was measured for up to 2 h after the incision. In a control group, the incision was made without anesthesia. Results: In the control group, the incision resulted in maximum excitation in the SDH neurons during surgery; spontaneous activity significantly increased for up to 30 min after the incision (P < 0.05) but did not significantly increase thereafter, returning to the preincision value. Halothane and isoflurane suppressed excitation of the neurons during the incision in a concentration-related manner. Administration of 2.2% halothane and 2.8% isoflurane during the incision and for up to 30 min after the incision almost abolished activity of the neurons for 30 min after the incision. The magnitude of neuronal activity 2 h after the incision was not significantly different among all groups, including the control group. Conclusions: The results demonstrate that administration of halothane and isoflurane does not attenuate development of hyperexcitability of SDH neurons despite the fact that excitation and spontaneous activity during and after the incision were greatly suppressed by administration of halothane and isoflurane.

    DOI

  • Severe paradoxical intracranial embolism and pulmonary emboli during hip hemiarthroplasty

    E Narimatsu, M Kawamata, M Hase, Y Kurimoto, Y Asai, A Namiki

    BRITISH JOURNAL OF ANAESTHESIA ( OXFORD UNIV PRESS )  91 ( 6 ) 911 - 913  2003年12月

    　概要を見る

    Both paradoxical intracranial embolism, an intracranial arterial embolism caused by venous embolic material that has passed through a right-to-left shunt, and pulmonary arterial embolism are life-threatening complications of joint arthroplasty. We report a case of severe paradoxical intracranial embolism and pulmonary embolism that occurred during hip hemiarthroplasty.

    DOI

  • Emergency endovascular stent-grafting for infected pseudoaneurysm of brachial artery.

    Infection   31   186 - 8  2003年

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共同研究・競争的資金等の研究課題 【 表示 ／ 非表示 】

  • ICU鎮静

  • 神経筋遮断薬の薬理学

  • 興奮性シナプス伝達の麻酔薬理学

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