Updated on 2025/08/22

写真a

 
KOBUNE Masayoshi
 
Organization
School of Medicine Department of Hematology Associate Professor
Title
Associate Professor
External link

Degree

  • Internal Medicine

Research Interests

  • 分子血液学 造血幹細胞 免疫治療 遺伝子治療

Research Areas

  • Life Science / Hematology and medical oncology

Professional Memberships

▼display all

Papers

  • Neuropeptide TIP39 induces autophagy in PTH2 receptor-positive myeloid neoplasms.

    Kento Ono, Hiroto Horiguchi, Satoshi Iyama, Ken Sato, Saori Ibuki-Shimoyama, Shotaro Shirato, Yusuke Sugama, Akari Goto, Masayoshi Kobune

    International journal of hematology   2025.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Neuropeptides are chemical messengers that are synthesized and released by nerve cells. Studies suggest that neuropeptides released from the nervous system in bone marrow may be involved in the regulation of hematopoiesis and survival of leukemic stem cells (LSC). Parathyroid hormone 2 receptor (PTH2R), a new LSC marker, is expressed on CD34 + leukemic cells. Its ligand, tuberoinfundibular peptide of 39 residues (TIP39), is expressed in the nervous system. However, the role of the TIP39-PTH2R axis in leukemic cells is unclear. We investigated the function of this axis in leukemic cell lines, as well as primary CD34 + myelodysplastic syndrome (MDS) and AML cells. Expression of PTH2R mRNA was higher in primary CD34 + MDS (GSE58831) or CD34 + CD38-AML (GSE24395) cells than in healthy volunteers. TIP39 reduced apoptosis in the leukemic cell lines Kasumi-1 and SKM-1. LC3-II expression was increased after incubation with TIP39, and was augmented in leukemic cell lines treated with lysosome inhibitors. This suggests that TIP39 could induce autophagy. Analysis of a public database (GSE58831) showed that high PTH2R expression was associated with poor overall survival and was an independent prognostic factor in MDS/AML patients. Our results suggest that the TIP39-PTH2R axis is a potential therapeutic target.

    DOI： 10.1007/s12185-025-03985-3

    PubMed

    researchmap

  • Prognostic impact of TET2 mutations in patients with acute myeloid leukemia: HM-SCREEN-Japan 01 and 02 study. International journal

    Satoshi Iyama, SungGi Chi, Masashi Idogawa, Takayuki Ikezoe, Kentaro Fukushima, Yoshikazu Utsu, Junya Kanda, Goichi Yoshimoto, Takahiro Kobayashi, Naoko Hosono, Takahiro Yamauchi, Takeshi Kondo, Yukinori Nakamura, Kensuke Kojima, Chikashi Yoshida, Akihiko Gotoh, Kazuhito Yamamoto, Junya Kuroda, Kenji Ishitsuka, Emiko Sakaida, Hiroto Horiguchi, Kohichi Takada, Hirofumi Ohnishi, Masayoshi Kobune, Yosuke Minami

    Annals of hematology   104 ( 1 )   275 - 284   2025.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Ten-eleven translocation-2 (TET2) gene mutations are observed in 12-20% of adult patients with acute myeloid leukemia (AML). The prognostic impact of TET2 mutations in patients with AML and myelodysplastic syndromes has been reported in several studies; however, their results remain controversial. Therefore, we aimed to analyze the prevalence and significance of TET2 mutations in patients with AML. Data were obtained from 331 patients with AML according to the Hematologic Malignancies-SCREEN-Japan 01 and 02 studies, which were prospective multicenter genomic profiling analyses. We found a distinct type of TET2 mutations, with a particularly detrimental prognosis in the patients. Thirty-five patients with TET2 'significant' mutations were identified (26 with frameshift mutations and nine with nonsense mutations). The proportion of patients with TET2 mutations was 31.7% (10.6% and 21.1% in the TET2 significant and non-significant mutation groups). The TET2 significant mutation group had a shorter OS than the TET2 non-significant mutation or wild-type TET2 group (median: 15.9 vs. 35.0 vs. 25.9 months). Regarding the response to chemotherapy according to TET2 status, the complete response (CR) or CR with incomplete count recovery rate was 37.1% in the TET2 significant mutation group and 46.6% in the non-significant mutation or wild-type group. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) improved patient prognosis in the TET2 non-significant mutation or wild-type TET2 group; however, allo-HSCT did not affect prognosis in the TET2 significant mutation group. This study indicates that certain TET2 mutations in patients with AML may have detrimental effects.

    DOI： 10.1007/s00277-025-06227-y

    PubMed

    researchmap

  • Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series. International journal

    Ryosuke Hirota, Masanori Sasaki, Satoshi Iyama, Kota Kurihara, Ryunosuke Fukushi, Hisashi Obara, Tsutomu Oshigiri, Tomonori Morita, Masahito Nakazaki, Takahiro Namioka, Ai Namioka, Rie Onodera, Yuko Kataoka-Sasaki, Shinichi Oka, Mitsuhiro Takemura, Ryo Ukai, Takahiro Yokoyama, Yuichi Sasaki, Tatsuro Yamashita, Masato Kobayashi, Yusuke Okuma, Reiko Kondo, Ryo Aichi, Satoko Ohmatsu, Noritaka Kawashima, Yoichi M Ito, Masayoshi Kobune, Kohichi Takada, Sumio Ishiai, Toru Ogata, Atsushi Teramoto, Toshihiko Yamashita, Jeffery D Kocsis, Osamu Honmou

    Journal of clinical medicine   13 ( 20 )   2024.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Objective: The safety, feasibility, and potential functional improvement following the intravenous infusion of mesenchymal stem cells (MSCs) were investigated in patients with chronic severe spinal cord injury (SCI). Methods: The intravenous infusion of autologous MSCs cultured in auto-serum under Good Manufacturing Practices (GMP) was administered to seven patients with chronic SCI (ranging from 1.3 years to 27 years after the onset of SCI). In addition to evaluating feasibility and safety, neurological function was evaluated using the American Spinal Injury Association Impairment Scale (AIS), International Standards for Neurological Classification of Spinal Cord Injury (ISCSCI-92), and Spinal Cord Independence Measure III (SCIM-III). Results: No serious adverse events occurred. Neither CNS tumors, abnormal cell growth, nor neurological deterioration occurred in any patients. While this initial case series was not blinded, significant functional improvements and increased quality of life (QOL) were observed at 90 and 180 days post-MSC infusion compared to pre-infusion status. One patient who had an AIS grade C improved to grade D within six months after MSC infusion. Conclusions: This case series suggests that the intravenous infusion of autologous MSCs is a safe and feasible therapeutic approach for chronic SCI patients. Furthermore, our data showed significant functional improvements and better QOL after MSC infusion in patients with chronic SCI. A blind large-scale study will be necessary to fully evaluate this possibility.

    DOI： 10.3390/jcm13206072

    PubMed

    researchmap

  • Novel method for assessing sinusoidal obstruction syndrome using four‐dimensional computed tomography

    Saori Shimoyama‐Ibuki, Satoshi Iyama, Yoshiya Ohashi, Kento Ono, Yusuke Sugama, Chisa Fujita, Akari Goto, Hiroto Horiguchi, Akihito Fujimi, Takeo Tanaka, Kohichi Takada, Koh‐Ichi Sakata, Masayoshi Kobune

    eJHaem   2024.7

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Introduction

    To diagnose sinusoidal obstruction syndrome/veno‐occlusive disease (SOS/VOD), transabdominal ultrasonography is usually used to detect hemodynamic changes, but we tried to detect the changes using four‐dimensional computed tomography (4D‐CT). A 42‐year‐old Japanese woman was diagnosed with late‐onset SOS/VOD with transabdominal ultrasonography and was also assessed using 4D‐CT. Method We analyzed the portal vein (PV) contrast effect every 1.5 seconds and plotted the values of the contrast effect. With this graph, we analyzed three hemodynamic parameters.

    Result

    We found that these parameters correlated with the patient's status and indicated stasis due to sinusoid constriction.

    Conclusion

    4D‐CT may become a helpful tool to diagnose and follow up with SOS/VOD.

    DOI： 10.1002/jha2.990

    researchmap

  • Gap junction beta-4 accelerates cell cycle progression and metastasis through MET-AKT activation in pancreatic cancer. International journal

    Joji Muramatsu, Yohei Arihara, Makoto Yoshida, Tomohiro Kubo, Hajime Nakamura, Kazuma Ishikawa, Hiromi Fujita, Shintaro Sugita, Takumi Konno, Takashi Kojima, Yutaka Kawano, Masayoshi Kobune, Kohichi Takada

    Cancer science   115 ( 5 )   1564 - 1575   2024.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Despite continuing advances in the development of effective new therapies, including immunotherapies, the prognosis of pancreatic cancer remains extremely poor. Gap junction proteins have become attractive targets for potential cancer therapy. However, the role of gap junction beta-4 (GJB4) protein remains unexplored in pancreatic cancer. Through bioinformatic analyses we discovered pancreatic cancer tissues showed higher levels of GJB4 transcripts compared to normal pancreatic tissues and this had a negative effect on overall survival in patients that had pancreatic cancer. The high expression of nuclear GJB4 was identified as a negative prognostic factor in such patients. Knockdown of GJB4 in cultured pancreatic cancer cells resulted in G0/G1 arrest followed by decreased cell proliferation and suppression of metastatic potential. The overexpression of GJB4 accelerated cell proliferation, migration, and invasion in a SUIT-2 cell line, whereas MET inhibitor canceled the acceleration. GJB4 suppression with siRNA significantly inhibited tumor growth in a mouse xenograft model. Mechanistically, suppression of GJB4 inhibited MET-AKT activities. Such data suggest that targeting the GJB4-MET axis could represent a promising new therapeutic strategy for pancreatic cancer.

    DOI： 10.1111/cas.16101

    PubMed

    researchmap

  • High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R.

    Akihito Fujimi, Yasuhiro Nagamachi, Naofumi Yamauchi, Naoki Onoyama, Naotaka Hayasaka, Teppei Matsuno, Kazuhiko Koike, Yoshiro Goto, Kohji Ihara, Junji Kato, Takuji Nishisato, Hiroshi Kawase, Tomoyuki Yano, Takayuki Kanaseki, Shintaro Sugita, Masayoshi Kobune

    Journal of clinical and experimental hematopathology : JCEH   64 ( 1 )   37 - 44   2024.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Peritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomatosa of unknown origin, exploratory laparoscopy was performed that revealed multiple white nodules and masses on the surfaces of the peritoneum, mesentery, and intestinal serosa. The histopathological and cytogenetic findings of the peritoneum revealed high-grade B-cell lymphoma, not otherwise specified, and a gain of MYC by fluorescence in-situ hybridization. The patient was treated with two cycles of R-CHOP therapy, followed by six cycles of dose-adjusted EPOCH-R therapy, and a complete metabolic response was confirmed by PET-CT. Since there are no specific radiological findings to confirm the diagnosis of PL, a histopathological diagnosis is usually required. Most PL exhibit an aggressive lymphoma phenotype and can be cured by appropriate chemotherapy. Therefore, early diagnosis and treatment are desirable.

    DOI： 10.3960/jslrt.23044

    PubMed

    researchmap

  • Successful Pregnancy and Fetal Outcomes Following Brentuximab Vedotin for Early Relapsed Classic Hodgkin Lymphoma After Autologous Stem Cell Transplant. International journal

    Akari Goto, Chisa Fujita, Hiroto Horiguchi, Satoshi Iyama, Masayoshi Kobune

    Cureus   16 ( 3 )   e57291   2024.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Brentuximab vedotin (BV), an anti-CD30 antibody with monomethyl auristatin E conjugate, has shown clinical effects against relapsed/refractory classic Hodgkin lymphoma (cHL) and hence is widely used in the clinical setting. We report a special clinical case of successful pregnancy and fetal outcome in a patient with cHL who achieved long-term remission with BV for early relapse after an autologous stem cell transplant (auto-SCT). A 27-year-old woman with advanced cHL achieved complete response (CR) after six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) regimen. Embryos obtained from intracytoplasmic sperm injection were cryopreserved before the initiation of induction chemotherapy. Despite achieving a second CR following intensive salvage chemotherapy, auto-SCT, and radiotherapy, she relapsed again six months after transplantation. BV monotherapy was administered as salvage therapy. She completed 16 cycles of BV and achieved CR. Six months after BV completion, she expressed her desire to bear a child. She achieved pregnancy through third in vitro fertilization and embryo transfer and delivered a healthy baby. BV may provide a potentially curative treatment for patients with cHL relapsed after auto-SCT. Pregnancy should be avoided during BV administration up to a certain period after the end of administration. Fertility preservation is important for adolescent and young adult cancer survivors, and patients should be informed of cancer-related infertility and fertility preservation options prior to the initiation of cancer treatment.

    DOI： 10.7759/cureus.57291

    PubMed

    researchmap

  • Successful Treatment With Venetoclax Plus Azacytidine Combined With Radiation Therapy and Donor Lymphocyte Infusion in a Patient With Extramedullary Relapse of Acute Myeloid Leukemia After Stem Cell Transplantation. International journal

    Shotaro Shirato, Satoshi Iyama, Akihito Fujimi, Satoshi Takahashi, Masayoshi Kobune

    Cureus   16 ( 2 )   e53655   2024.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Extramedullary (EM) relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloid leukemia (AML) is rare and causes systemic relapse. Consequently, the prognosis is very poor because limited treatment is feasible in post-transplant patients. The efficacy and safety of venetoclax (VEN), a newly developed oral inhibitor of B-cell leukemia/lymphoma-2, plus azacytidine (AZA) in patients newly diagnosed with AML who are ineligible for intensive chemotherapy have been reported. We report a case in which VEN + AZA salvage treatment following radiation therapy and donor lymphocyte infusion afforded promising results in a patient with AML who showed post-allo-HSCT EM relapse.

    DOI： 10.7759/cureus.53655

    PubMed

    researchmap

  • Adherence of denosumab treatment for low bone mineral density in Japanese people living with HIV: a retrospective observational study. International journal

    Yusuke Kunimoto, Ryosuke Matamura, Hiroshi Ikeda, Hiroto Horiguchi, Satoshi Fujii, Masayoshi Kobune, Masahide Fukudo, Takaki Toda

    Journal of pharmaceutical health care and sciences   9 ( 1 )   45 - 45   2023.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Long-term care issues, specifically metabolic bone disorders, are a concern for people living with human immunodeficiency virus (PLWH) who undergo life-long antiretroviral therapy (ART). Previous clinical trials with denosumab, an anti-RANKL antibody inhibitor, have revealed its effectiveness in increasing bone mineral density (BMD) in patients with osteoporosis. However, there are limited data on adherence and effectiveness of denosumab treatment for osteoporosis in PLWH. Hence, this study aimed to investigate the adherence and effectiveness of denosumab treatment for osteoporosis in Japanese PLWH. METHODS: This study is a retrospective exploratory analysis of 29 Japanese PLWH who initiated denosumab treatment for osteoporosis, between 2013 and 2021. The study included patients who received at least one dose of denosumab every 6 months. Adherence and persistence were defined as receiving two consecutive injections of denosumab 6 months ± 4 weeks apart and 6 months + 8 weeks apart, respectively. The primary outcome measure of the study was the adherence of denosumab treatment for 24 months. The secondary outcome measures included treatment persistence and BMD. The period after January 2020 was defined as the coronavirus disease 2019 (COVID-19) pandemic period, and its impact on adherence was investigated. RESULTS: The treatment adherence rates at 12 and 24 months were 89.7% and 60.7%, respectively. By contrast, the treatment persistence at 12 and 24 months was 100% and 85.7%, respectively. More patients in the group who initiated denosumab treatment after the COVID-19 pandemic reached non-adherence than in the group who initiated denosumab treatment before the pandemic. BMD at the lumbar spine and femoral neck significantly increased compared to that at baseline, with median percentage changes of 8.7% (p < 0.001) and 3.5% (p = 0.001), respectively. CONCLUSIONS: The results showed that patients in the study had a high rate of non-adherence but a lower rate of non-persistence. Additionally, PLWH on ongoing ART experienced increased BMD with denosumab treatment. This study provides an opportunity to improve future strategies for denosumab treatment in the Japanese PLWH.

    DOI： 10.1186/s40780-023-00315-9

    PubMed

    researchmap

  • Acute Abdomen and Adrenal Swelling as the First Manifestations of TAFRO Syndrome.

    Akihito Fujimi, Yasuhiro Nagamachi, Naofumi Yamauchi, Naoki Onoyama, Teppei Matsuno, Naoya Miyajima, Kazuhiko Koike, Yoshiro Goto, Kohji Ihara, Takuji Nishisato, Masayoshi Kobune

    Internal medicine (Tokyo, Japan)   62 ( 11 )   1675 - 1681   2023.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    TAFRO syndrome, a rare systemic inflammatory disorder, commonly develops in an acute or subacute manner, with an aggressive clinical behavior. A substantial number of cases of TAFRO syndrome presenting with abdominal pain, and adrenal abnormalities on imaging have also been reported. A 54-year-old man developed severe acute abdominal pain. Bilateral adrenal swelling was detected on computed tomography. Although the abdominal pain resolved spontaneously, a fever and anasarca were observed. The patient was eventually diagnosed with TAFRO syndrome, and corticosteroid administration resulted in remission. TAFRO syndrome should be included in the differential diagnosis of acute abdomen and adrenal abnormalities.

    DOI： 10.2169/internalmedicine.0267-22

    PubMed

    researchmap

  • Multiple Myeloma with Hyperammonemia Treated with Novel Agents: A Case Series of Three Patients.

    Hajime Nakamura, Kohichi Takada, Kazuyuki Murase, Hiroshi Ikeda, Satoshi Iyama, Tatsuo Manabe, Masayoshi Kobune

    Internal medicine (Tokyo, Japan)   62 ( 5 )   775 - 778   2023.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Multiple myeloma (MM) is a cancer characterized by the expansion of plasma cells in the bone marrow. Survival times of patients with MM have increased due to the development of novel therapeutic agents. We herein highlight three MM cases that had a poor prognosis despite treatment with novel therapeutic agents. Of note, all patients presented with hyperammonemia that led to a consciousness disorder. The outcome for patients with MM showing high levels of serum ammonia continues to be poor, even with the use of novel therapies. For such patients showing a consciousness disorder, hyperammonemia should be considered as a possible cause.

    DOI： 10.2169/internalmedicine.0010-22

    PubMed

    researchmap

  • [Diagnosis and treatment of anemia by malnutrition in the elderly].

    Masayoshi Kobune

    [Rinsho ketsueki] The Japanese journal of clinical hematology   64 ( 9 )   900 - 907   2023

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Recently, nutritional anemia has been increasing, particularly refractory iron-deficiency anemia, which has become more common not only among older adults but also among relatively young people. Coexisting conditions such as chronic inflammatory disease, gastrointestinal disease, and chronic kidney disease can all complicate diagnosis and treatment. In many cases, appropriate treatment can improve anemia. Same as iron, copper, and zinc are proven to be absorbed from the transporter in the upper gastrointestinal mucosa, but potential zinc and copper deficiencies are increasingly being reported in cases of iron deficiency. Serum zinc deficiency is more common in cases of severe iron-deficiency anemia. This paper provides an overview of refractory iron-deficiency anemia and discusses the molecular groups involved in iron dynamics, zinc, and copper metabolism.

    DOI： 10.11406/rinketsu.64.900

    PubMed

    researchmap

  • Potential drug-drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan. International journal

    Yusuke Kunimoto, Ryosuke Matamura, Hiroshi Ikeda, Satoshi Fujii, Tomoko Kimyo, Manabu Kitagawa, Hiromasa Nakata, Masayoshi Kobune, Atsushi Miyamoto, Masahide Fukudo

    Journal of pharmaceutical health care and sciences   7 ( 1 )   43 - 43   2021.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Potential drug-drug interactions (PDDIs) commonly occur because of aging and comorbidities in people living with human immunodeficiency virus (HIV; PLWH). Protease inhibitors and non-nucleoside reverse transcriptase inhibitors have been reported to cause PDDIs in these patients. However, there are few reports of PDDIs in the era of treatment using integrase strand transfer inhibitors. Therefore, we investigated PDDIs in Japanese PLWH receiving antiretroviral drugs (ARVs). METHODS: This was a cross-sectional observational study conducted in Japanese outpatients. All eligible patients who had received ARV therapy for at least 48 weeks were enrolled. The primary endpoint was the incidence of PDDIs detected using the Lexicomp® interface. RESULTS: Of the 71 eligible patients, 51 (71.8%) were prescribed concomitant non-ARV medications. In 21 patients (29.6%), PDDIs with the potential to reduce the effects of ARVs occurred, although the HIV load was suppressed in all cases. Polypharmacy (the use of ≥5 non-ARVs) was observed in 25 patients (35.2%). There was a significantly higher median number of non-ARV medications in the PDDI group than in the non-PDDI group (6 vs. 3, P <  0.001). Furthermore, the proportion of patients on polypharmacy was significantly higher in those with PDDIs than in those without PDDIs (81.0% vs. 26.7%, P <  0.001). CONCLUSIONS: The incidence of PDDIs is relatively high in Japanese PLWH, even in the era of treatment using integrase strand transfer inhibitors. Therefore, it is important for patients and health care providers to be constantly aware of PDDIs associated with ARV treatment.

    DOI： 10.1186/s40780-021-00226-7

    PubMed

    researchmap

  • Combination of psoas muscle mass index and neutrophil/lymphocyte ratio as a prognostic predictor for patients undergoing nonsurgical hepatocellular carcinoma therapy Reviewed International journal

    Yusuke Sugama, Koji Miyanishi, Takahiro Osuga, Shingo Tanaka, Kota Hamaguchi, Ryo Ito, Hiroki Sakamoto, Tomohiro Kubo, Hiroyuki Ohnuma, Kazuyuki Murase, Kohich Takada, Masayoshi Kobune, Junji Kato

    JGH Open   5 ( 12 )   1335 - 1343   2021.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    BACKGROUND AND AIM: Reliable predictors for hepatocellular carcinoma (HCC) are urgently needed. The psoas muscle index (PMI) is a simple and rapid method for evaluating muscle atrophy. Furthermore, the neutrophil/lymphocyte ratio (NLR) is a prognostic factor that is easy to calculate in everyday clinical practice. We aimed to investigate the value of the PMI and NLR as prognostic factors for patients receiving nonsurgical HCC therapy, hepatic arterial infusion chemotherapy (HAIC), transcatheter arterial chemoembolization (TACE), or molecular targeted drugs such as sorafenib (SOR) and lenvatinib (LEN). METHODS: We enrolled 87 patients with HCC who were treated with HAIC, TACE, SOR, or LEN. The primary endpoint was overall survival (OS) with variable PMI or NLR status. For Barcelona Clinic Liver Cancer (BCLC)-B patients, useful prognostic factors were examined by comparing the OS between stratified groups. Prognostic factors including PMI and NLR were evaluated by univariate and multivariate analysis. RESULTS: Analysis of HAIC or TACE (HAIC/TACE) and SOR or LEN (SOR/LEN) patients showed significant differences in OS between low and high PMI. In patients treated with TACE, there was a significant difference in OS between low and high NLR. For BCLC-B and low PMI, the prognosis was significantly worse for SOR/LEN than for TACE, although there was no difference for high PMI, suggesting that PMI may be useful for treatment selection. In addition, the prognostic formula composed of PMI, NLR, and up-to-seven criteria developed in the present study may be useful. CONCLUSION: PMI and NLR are considered to be independent prognostic factors for HCC.

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jgh3.12676

    DOI： 10.1002/jgh3.12676

    PubMed

    researchmap

  • Six-transmembrane epithelial antigen of the prostate 1 accelerates cell proliferation by targeting c-Myc in liver cancer cells. International journal

    Kazutaka Iijima, Hajime Nakamura, Kohichi Takada, Naotaka Hayasaka, Tomohiro Kubo, Yui Umeyama, Satoshi Iyama, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Oncology letters   22 ( 1 )   546 - 546   2021.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) has emerged as an ideal target in cancer therapeutics. However, the functions of STEAP1 in liver cancer remain unexplored. The current study aimed to characterize the biological roles of STEAP1 in liver cancer. STEAP1 expression was upregulated in tumor tissues, and high STEAP1 expression was associated with poor clinical outcomes in patients with liver cancer, according to several publicly available datasets. STEAP1 silencing using small interfering RNA inhibited cell proliferation and was accompanied by G1 arrest induced by the suppression of cyclin D1 and the promotion of p27. STEAP1 silencing suppressed c-Myc expression, which was identified as a component in STEAP1 signal transduction by mining publicly available datasets and was then confirmed by PCR array. In conclusion, the knockdown of STEAP1 in liver cancer cell lines led to inhibition of cell proliferation involving G1 arrest by suppressing c-Myc. The present study provides a preclinical concept for STEAP1 as a druggable target in liver cancer.

    DOI： 10.3892/ol.2021.12807

    PubMed

    researchmap

  • Possible clinical outcomes using early enteral nutrition in individuals with allogeneic hematopoietic stem cell transplantation: A single-center retrospective study International journal

    Satoshi Iyama, Hiroomi Tatsumi, Tsukasa Shiraishi, Masahiro Yoshida, Ayumi Tatekoshi, Akihito Endo, Taichiro Ishige, Yuh Shiwa, Soushi Ibata, Akari Goto, Kana Nagashima, Hiroto Horiguchi, Chisa Fujita, Hiroshi Ikeda, Kohichi Takada, Takayuki Nobuoka, Yusuke Kamihara, Shohei Kikuchi, Tsutomu Sato, Hirofumi Ohnishi, Shin-ichi Yokota, Masayoshi Kobune

    Nutrition   83   111093 - 111093   2021.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    OBJECTIVES: Intensive nutritional support during allogeneic hematopoietic stem cell transplantation (allo-HSCT) yields improved clinical outcomes. However, the clinical implications of early enteral nutrition (EN) in allo-HSCT remain unclear. This retrospective study was conducted to determine the significance of early EN in individuals who underwent allo-HSCT, and the association between early nutritional intervention and clinical outcomes, including the status of the intestinal microbiome. METHODS: Thirty-one participants received EN before conditioning. The intestinal microbiota was examined by meta 16S rRNA gene sequencing of fecal samples. RESULTS: The median body mass variation was only -0.35 kg on day 60. The probability of 2-y overall survival was 61.1%. The cumulative incidence of treatment-related mortality was 17.4%, and those of acute graft-versus-host disease were 32.3% (grades II-IV) and 3.2% (grades III-IV). Chronic graft-versus-host disease was observed in four participants. Dysbiosis of the intestines and acute graft-versus-host disease occurred simultaneously, and Enterococcus species were abundant. CONCLUSIONS: Our results suggest that early nutritional support can improve the outcomes for individuals who have undergone allo-HSCT and can maintain homeostasis of their intestinal microbiome. Future prospective clinical trials are required to elucidate the role of EN in allo-HSCT and the association between the intestinal microbiome and EN.

    DOI： 10.1016/j.nut.2020.111093

    PubMed

    researchmap

  • MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model. International journal

    Hiroki Sakamoto, Koji Miyanishi, Shingo Tanaka, Ryo Ito, Kota Hamaguchi, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yusaku Nakabeppu, Masayoshi Kobune, Junji Kato

    Scientific reports   11 ( 1 )   3599 - 3599   2021.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Non-alcoholic steatohepatitis (NASH)-related HCC is associated with oxidative stress. However, the mechanisms underlying the development of NASH-related HCC is unclear. MUTYH is one of the enzymes that is involved in repair of oxidative DNA damage. The aim of this study was to investigate the association between MUTYH and NASH-related hepatocarcinogenesis. MUTYH wild-type (Mutyh+/+), heterozygous (Mutyh+/-), and MUTYH-null (Mutyh-/-) mice were fed a high-fat high-cholesterol (HFHC) diet or HFHC + high iron diet (20 mice per group) for 9 months. Five of 20 Mutyh-/- mice fed an HFHC + high iron diet developed liver tumors, and they developed more liver tumors than other groups (especially vs. Mutyh+/+ fed an HFHC diet, P = 0.0168). Immunohistochemical analysis revealed significantly higher accumulation of oxidative stress markers in mice fed an HFHC + high iron diet. The gene expression profiles in the non-tumorous hepatic tissues were compared between wild-type mice that developed no liver tumors and MUTYH-null mice that developed liver tumors. Gene Set Enrichment Analysis identified the involvement of the Wnt/β-catenin signaling pathway and increased expression of c-Myc in MUTYH-null liver. These findings suggest that MUTYH deficiency is associated with hepatocarcinogenesis in patients with NASH with hepatic iron accumulation.

    DOI： 10.1038/s41598-021-83138-8

    PubMed

    researchmap

  • Case series of three patients with hereditary diffuse gastric cancer in a single family: Three case reports and review of literature International journal

    Masahiro Hirakawa, Kohichi Takada, Masanori Sato, Chisa Fujita, Naotaka Hayasaka, Takayuki Nobuoka, Shintaro Sugita, Aki Ishikawa, Miyako Mizukami, Hiroyuki Ohnuma, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Ichiro Takemasa, Tadashi Hasegawa, Akihiro Sakurai, Junji Kato

    World Journal of Gastroenterology   26 ( 42 )   6689 - 6697   2020.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Baishideng Publishing Group Inc.  

    BACKGROUND: Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome often associated with germline mutations in the CDH1 gene. However, the frequency of CDH1 mutations is low in patients with HDGC in East Asian countries. Herein, we report three cases of HDGC harboring a missense CDH1 variant, c.1679C>G, from a single Japanese family. CASE SUMMARY: A 26-year-old female (Case 1) and a 51-year-old male (father of Case 1), who had a strong family history of gastric cancer, were diagnosed with advanced diffuse gastric cancer. After genetic counselling, a 25-year-old younger brother of Case 1 underwent surveillance esophagogastroduodenoscopy that detected small signet ring cell carcinoma foci as multiple pale lesions in the gastric mucosa. Genetic analysis revealed a CDH1 c.1679C>G variant in all three patients. CONCLUSION: It is important for individuals suspected of having HDGC to be actively offered genetics evaluation. This report will contribute to an increased awareness of HDGC.

    DOI： 10.3748/wjg.v26.i42.6689

    PubMed

    researchmap

  • Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer International journal

    Hajime Nakamura, Kohichi Takada, Kazuyuki Murase, Hiroki Sakamoto, Naotaka Hayasaka, Kazuma Ishikawa, Yuki Ikeda, Makoto Yoshida, Satoshi Iyama, Ko Kobayashi, Tetsuya Shindo, Shintaro Sugita, Koji Miyanishi, Masayoshi Kobune, Naoya Masumori, Junji Kato

    Case Reports in Oncological Medicine   2020   1 - 4   2020.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

    Papillary thyroid cancer (PTC) is considered an indolent cancer, but some PTC patients do present with distant metastases and treatment strategies for such patients are not well established. Recently, lenvatinib, an inhibitor of multiple tyrosine kinases, has been introduced to treat patients with advanced PTC but carries a risk of serious adverse events such as hemorrhage. Here, we report a PTC patient with a left adrenal metastasis and lenvatinib-induced hemorrhage who underwent successful surgical resection and was subsequently treated with a lower dose of lenvatinib. The patient has now been in a stable state with no adverse events for nearly two years. This case highlights the importance of surgical resection of metastatic PTC and subsequent lenvatinib therapy, even when the tumor is at an advanced stage.

    Other Link： http://downloads.hindawi.com/journals/crionm/2020/2107430.xml

    DOI： 10.1155/2020/2107430

    PubMed

    researchmap

  • Acquired amegakaryocytic thrombocytopenic purpura possibly induced by anti-PD-1 antibody

    Satoshi Iyama, K. Takada, M. Yoshida, D. Takahashi, M. Kobune

    Annals of Hematology   99 ( 7 )   1669 - 1670   2020.7

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Other Link： https://link.springer.com/article/10.1007/s00277-020-04053-y/fulltext.html

    DOI： 10.1007/s00277-020-04053-y

    researchmap

  • Successful brentuximab vedotin monotherapy against late relapse of classical Hodgkin lymphoma 6 years after first remission

    Kana Nagashima, Shohei Kikuchi, Satoshi Iyama, Chisa Fujita, Akari Goto, Hiroto Horiguchi, Masayoshi Kobune

    Clinical Case Reports   8 ( 3 )   466 - 468   2020.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley-Blackwell Publishing Ltd  

    DOI： 10.1002/ccr3.2688

    researchmap

  • FOXO3a Activation by HDAC Class IIa Inhibition Induces Cell Cycle Arrest in Pancreatic Cancer Cells

    Makoto Usami, Shohei Kikuchi, Kohichi Takada, Michihiro Ono, Yusuke Sugama, Yohei Arihara, Naotaka Hayasaka, Hajime Nakamura, Yuuki Ikeda, Masahiro Hirakawa, Makoto Yoshida, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Pancreas   49 ( 1 )   135 - 142   2020.1

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

    DOI： 10.1097/mpa.0000000000001462

    researchmap

  • [Diffuse large B cell lymphoma with HIV infection presented with disseminated thromboembolism during antiretroviral therapy].

    Hiroshi Ikeda, Masayoshi Kobune, Kana Nagashima, Chisa Fujita, Akari Goto, Hiroto Horiguchi, Shohei Kikuchi, Kazuyuki Murase, Kohichi Takada, Satoshi Iyama, Junji Kato

    [Rinsho ketsueki] The Japanese journal of clinical hematology   61 ( 11 )   1595 - 1599   2020

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Patients with HIV are at higher risk of developing thrombosis than the general population. We present a rare case of a 57-year-old Japanese man with HIV infection and a malignant lymphoma. He had fever with unknown origin and cervical lymph node swelling 2 months before his hospital visit. Because he was positive for the HIV antibody, he was referred to our HIV special outpatient section. HIV RNA level was found to be 846,680 copies/ml. Therefore, antiretroviral therapy of DTG/ABC/3TC was initiated. However, the high fever continued for 7 days after treatment initiation; moreover, renal dysfunction was progressive. After admission, antibiotic therapy was initiated, due to which the fever subsided. However, renal dysfunction continued to progress. Fourteen days later, he died due to acute renal failure with hyperkalemia. An autopsy revealed a large mass in the spleen, and histological findings revealed a diffuse large B cell lymphoma (DLBCL). Furthermore, thrombi were detected in the right and left ventricles, right atrium, iliac artery, and renal artery. Pathological findings revealed that the thrombus induced the renal failure. These thrombi contained fibrin with inflammatory cell infiltration but not tumor cells. Patients with HIV and malignant lymphoma are at a higher risk of thrombosis. It is important to consider thrombosis during the treatment of patients with HIV.

    DOI： 10.11406/rinketsu.61.1595

    PubMed

    researchmap

  • Management of Multiple Arteriovenous Malformations of the Small Bowel

    Masahiro Hirakawa, Rie Ishizuka, Masanori Sato, Naotaka Hayasaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Tatsuya Ito, Takayuki Nobuoka, Koji Miyanishi, Masayoshi Kobune, Ichiro Takemasa, Junji Kato

    Case Reports in Medicine   2019   1 - 4   2019.12

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

    A 62-year-old Japanese female was referred to our hospital with gastrointestinal bleeding. Although small-bowel bleeding was suspected, no bleeding source was identified by enhanced computed tomography (CT), video capsule endoscopy (VCE), and double-balloon enteroscopy (DBE). Five years later, the patient had recurrent intermittent bloody stools with a significant decrease in hemoglobin levels. Although no active bleeding was observed on antegrade DBE, we detected a pulsatile submucosal uplift accompanied by a small red patch on the top of the uplift in the jejunum. Arteriovenous malformation (AVM) was suspected as the cause of small-bowel bleeding. Multiple-phase CT showed a number of small vascular ectasias during the arterial phase in the jejunum, and we confirmed the presence of multiple AVMs in the jejunum by selective angiography. To identify the location of the lesions and determine the minimal surgical margins, we performed intraoperative selective angiography with indocyanine green (ICG) injection. This technique allowed us to clearly observe the region and perform segmental small-bowel resection with minimal surgical margin. The patient reported that she has had no gastrointestinal bleeding at the two years follow-up visit.

    Other Link： http://downloads.hindawi.com/journals/crim/2019/2046857.xml

    DOI： 10.1155/2019/2046857

    researchmap

  • Exceptionally rapid response to pembrolizumab in a SMARCA4‐deficient thoracic sarcoma overexpressing PD‐L1: A case report

    Kohichi Takada, Shintaro Sugita, Kazuyuki Murase, Tomoki Kikuchi, Ginji Oomori, Ryo Ito, Naotaka Hayasaka, Koji Miyanishi, Satoshi Iyama, Hiroshi Ikeda, Masayoshi Kobune, Makoto Emori, Junji Kato, Tadashi Hasegawa

    Thoracic Cancer   10 ( 12 )   2312 - 2315   2019.12

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/1759-7714.13215

    DOI： 10.1111/1759-7714.13215

    researchmap

  • BH3 profiling discriminates the anti‑apoptotic status of 5‑fluorouracil‑resistant colon cancer cells. Reviewed International journal

    Kazuma Ishikawa, Yutaka Kawano, Yohei Arihara, Tomohiro Kubo, Kohichi Takada, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Oncology reports   42 ( 6 )   2416 - 2425   2019.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    5‑Fluorouracil (5‑FU) is a cytotoxic anticancer drug commonly used for patients with advanced colon cancer. This drug effectively reduces the size of tumors to a certain degree; however, cancer cells can gradually acquire resistance, resulting in disease progression. To identify the mechanism of 5‑FU resistance, we established three 5‑FU‑resistant colon cancer cell lines and analyzed both apoptosis‑related protein expression levels and BH3 profiling. These 5‑FU‑resistant colon cancer cell lines acquired apoptotic resistance to 5‑FU. Although apoptosis‑related protein expression levels were altered in each 5‑FU‑resistant colon cancer cell line variably, BH3 profiling indicated BCLXL dependence in 5‑FU‑resistant HT‑29 cells only. Functional BCLXL inhibition in 5‑FU‑resistant HT‑29 cells not only sensitized the cells to apoptosis but also overcame 5‑FU resistance. The apoptotic BIM protein was preferentially sequestered, thereby resulting in acquired dependence on BCLXL for survival. Additionally, in vivo models showed that BCLXL inhibition controlled tumor progression. These results indicate that BH3 profiling facilitates the identification of the functional role of anti‑apoptotic proteins during drug resistance and has clinical implications for colon cancer in targeting specific proteins such as BCLXL.

    DOI： 10.3892/or.2019.7373

    PubMed

    researchmap

  • Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment

    Kohichi Takada, Kazuyuki Murase, Hajime Nakamura, Naotaka Hayasaka, Yohei Arihara, Satoshi Iyama, Hiroshi Ikeda, Makoto Emori, Shintaro Sugita, Katsuyuki Nakamura, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Internal Medicine   58 ( 20 )   3009 - 3012   2019.10

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Internal Medicine  

    DOI： 10.2169/internalmedicine.2790-19

    researchmap

  • EPO-R+ myelodysplastic cells with ring sideroblasts produce high erythroferrone levels to reduce hepcidin expression in hepatic cells

    Shogo Miura, Masayoshi Kobune, Hiroto Horiguchi, Shohei Kikuchi, Satoshi Iyama, Kazuyuki Murase, Akari Goto, Hiroshi Ikeda, Kohichi Takada, Koji Miyanishi, Junji Kato

    Blood Cells, Molecules, and Diseases   78   1 - 8   2019.9

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bcmd.2019.04.014

    researchmap

  • Six-transmembrane epithelial antigen of the prostate 1 protects against increased oxidative stress via a nuclear erythroid 2-related factor pathway in colorectal cancer

    Hajime Nakamura, Kohichi Takada, Yohei Arihara, Naotaka Hayasaka, Kazuyuki Murase, Satoshi Iyama, Masayoshi Kobune, Koji Miyanishi, Junji Kato

    Cancer Gene Therapy   26 ( 9-10 )   313 - 322   2019.9

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Other Link： http://www.nature.com/articles/s41417-018-0056-8

    DOI： 10.1038/s41417-018-0056-8

    researchmap

  • 小型混合型肝癌の1例

    大須賀 崇裕, 宮西 浩嗣, 田中 信悟, 中村 元, 坂本 拡基, 大沼 啓之, 村瀬 和幸, 高田 弘一, 小船 雅義, 加藤 淳二, 永山 稔, 木村 康利, 竹政 伊知朗, 辻脇 光洋, 長谷川 匡

    肝臓   60 ( 8 )   294 - 301   2019.8

    　More details

  • Combination of eribulin plus AKT inhibitor evokes synergistic cytotoxicity in soft tissue sarcoma cells. Reviewed International journal

    Naotaka Hayasaka, Kohichi Takada, Hajime Nakamura, Yohei Arihara, Yutaka Kawano, Takahiro Osuga, Kazuyuki Murase, Shohei Kikuchi, Satoshi Iyama, Makoto Emori, Shintaro Sugita, Tadashi Hasegawa, Akira Takasawa, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Scientific reports   9 ( 1 )   5759 - 5759   2019.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    An activated AKT pathway underlies the pathogenesis of soft tissue sarcoma (STS), with over-expressed phosphorylated AKT (p-AKT) correlating with a poor prognosis in a subset of STS cases. Recently, eribulin, a microtubule dynamics inhibitor, has demonstrated efficacy and is approved in patients with advanced/metastatic liposarcoma and breast cancer. However, mechanisms of eribulin resistance and/or insensitivity remain largely unknown. In this study, we demonstrated that an increased p-AKT level was associated with eribulin resistance in STS cells. We found a combination of eribulin with the AKT inhibitor, MK-2206, synergistically inhibited STS cell growth in vivo as well as in vitro. Mechanistically, eribulin plus MK-2206 induced G1 or G2/M arrest by down-regulating cyclin-dependent kinases, cyclins and cdc2, followed by caspase-dependent apoptosis in STS cells. Our findings demonstrate the significance of p-AKT signaling for eribulin-resistance in STS cells and provide a rationale for the development of an AKT inhibitor in combination with eribulin to treat patients with STS.

    DOI： 10.1038/s41598-019-42300-z

    PubMed

    researchmap

  • Successful Treatment of Hepatocellular Carcinoma with Transcatheter Arterial Chemoembolization followed by Radical Liver Transplantation in a Patient with Severe Liver Damage

    Hajime Nakamura, Yutaka Kawano, Koji Miyanishi, Kazuma Ishikawa, Tomohiro Kubo, Shingo Tanaka, Kohichi Takada, Masayoshi Kobune, Kohei Harada, Norio Kawamura, Tsuyoshi Shimamura, Hiromi Kanno-Okada, Junji Kato

    Case Reports in Oncology   12 ( 1 )   289 - 296   2019.4

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：S. Karger AG  

    Introduction: Liver transplantation for hepatocellular carcinoma (HCC) has been established as a curative therapy of underlying liver disease and cancer. However, the role of liver transplantation remains controversial for patients with HCC beyond Milan criteria. Case Presentation: A man in his 50s who was diagnosed as having two foci of HCC and advanced liver cirrhosis was referred to our hospital for further examination and treatment. Both foci of HCC were located in segment 8 of the liver and measured 39 and 9 mm. Endoscopy showed esophageal varices that had a high risk of bleeding. After endoscopic ligation of the esophageal varices, he underwent transcatheter arterial chemoembolization (TACE) for downstaging of the advanced HCCs. No further liver deterioration was observed after TACE, and HCC staging was successfully downstaged to within the Milan criteria. One hundred ten days after TACE, he underwent liver transplantation; at 2.5 years after transplantation, he remains alive without HCC recurrence. Discussion/Conclusion: There are only a few treatment options available for patients with advanced HCC and severe liver damage. Multidisciplinary treatment such as locoregional treatments and prophylaxis of variceal bleeding may result in tumor downstaging, enabling radical liver transplantation without further exacerbation of liver damage.

    DOI： 10.1159/000499703

    researchmap

  • miR-7977 inhibits the Hippo-YAP signaling pathway in bone marrow mesenchymal stromal cells. Reviewed International journal

    Masahiro Yoshida, Hiroto Horiguchi, Shohei Kikuchi, Satoshi Iyama, Hiroshi Ikeda, Akari Goto, Yutaka Kawano, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Junji Kato, Masayoshi Kobune

    PloS one   14 ( 3 )   e0213220   2019

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    We and others have demonstrated that various abnormalities of the bone marrow (BM) mesenchymal stromal cells (MSCs) such as aberrant cytokine expression, abnormal hedgehog signaling, and impaired miRNA biogenesis are observed in patients with acute myeloid leukemia (AML). However, underlying mechanisms to induce the dysfunction of BM MSCs have not yet been clarified. We previously showed that AML cells release abundant exosomal miR-7977, which, in turn, enters BM mesenchymal stromal cells (MSCs). However, the precise function of miR-7977 is not known. In this study, we performed transduction of a miR-7977 mimic into MSCs, compared transcriptomes between control-transduced (n = 3) and miR-7977-transduced MSCs (n = 3), and conducted pathway analysis. The array data revealed that the expression of 0.05% of genes was reduced 2-fold and the expression of 0.01% of genes was increased 2-fold. Interestingly, approximately half of these genes possessed a miR-7977 target site, while the other genes did not, suggesting that miR-7977 regulates the gene expression level directly and indirectly. Gene set enrichment analysis showed that the gene sets of Yes-associated protein 1 (YAP1) _up were significantly enriched (p<0.001, q<0.25), suggesting that miR-7977 modulates the Hippo-YAP signaling pathway. Visualization of pathway and network showed that miR-7977 significantly reduced the expression of Hippo core kinase, STK4. miR-7977 inactivated the Hippo-YAP signaling pathway as proven by GFP-tagged YAP nuclear trans localization and TEAD reporter assay. The miR-7977-transduced MSC cell line, HTS-5, showed elevated saturation density and enhanced entry into the cell cycle. These results suggest that miR-7977 is a critical factor that regulates the Hippo-YAP signaling pathway in BM-MSCs and may be involved in the upregulation of leukemia-supporting stroma growth.

    DOI： 10.1371/journal.pone.0213220

    PubMed

    researchmap

  • A case of small combined hepatocellular-cholangiocellular carcinoma

    Takahiro Osuga, Koji Miyanishi, Shingo Tanaka, Hajime Nakamura, Hiroki Sakamoto, Hiroyuki Onuma, Kazuyuki Murase, Koichi Takada, Masayoshi Kobune, Junji Kato, Minoru Nagayama, Yasutoshi Kimura, Ichiro Takemasa, Mitsuhiro Tsujiwaki, Tadashi Hasegawa

    Acta Hepatologica Japonica   60 ( 8 )   294 - 301   2019

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Society of Hepatology  

    DOI： 10.2957/kanzo.60.294

    researchmap

  • Denosumab prevents bone loss in newly diagnosed malignant lymphoma patients undergoing corticosteroid-containing chemotherapy: A prospective, non-randomized study

    Ayumi Tatekoshi, Tsutomu Sato, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Masahiro Yoshida, Soushi Ibata, Akari Hashimoto, Yusuke Kamihara, Hiroto Horiguchi, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Sapporo Medical journal   87 ( 1-6 )   35 - 47   2018.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Sapporo Medical University  

    DOI： 10.15114/smj.87.35

    researchmap

  • An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma. Reviewed International journal

    Akira Sakurada, Koji Miyanishi, Shingo Tanaka, Masanori Sato, Hiroki Sakamoto, Yutaka Kawano, Kohichi Takada, Yusaku Nakabeppu, Masayoshi Kobune, Junji Kato

    Free radical biology & medicine   129   88 - 96   2018.12

    　More details

  • 低用量IL2はBCL2の発現を誘導することでCD4制御性T細胞のアポトーシスを抑制する(Low-close interleukin-2 induces BCL2 expression and resistance to apoptosis in CD4 regulatory T Cells) Reviewed

    松野 鉄平, 村瀬 和幸, 高田 弘一, 河野 豊, 平川 昌宏, 宮西 浩嗣, 小船 雅義, 加藤 淳二

    札幌医学雑誌   87 ( 1-6 )   49 - 61   2018.12

    　More details

    Language：English   Publisher：札幌医科大学  

    Ichushi

    researchmap

  • Increased Duodenal Iron Absorption through Upregulation of Ferroportin 1 due to the Decrement in Serum Hepcidin in Patients with Chronic Hepatitis C

    Masanori Sato, Koji Miyanishi, Shingo Tanaka, Akira Sakurada, Hiroki Sakamoto, Yutaka Kawano, Kohichi Takada, Masayoshi Kobune, Junji Kato

    Canadian Journal of Gastroenterology and Hepatology   2018   1 - 9   2018.8

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

    DOI： 10.1155/2018/2154361

    researchmap

  • High expression of nucleoporin 133 mRNA in bone marrow CD138+ cells is a poor prognostic factor in multiple myeloma Reviewed

    Soushi Ibata, Masayoshi Kobune, Shohei Kikuchi, Masahiro Yoshida, Shogo Miura, Hiroto Horiguchi, Kazuyuki Murase, Satoshi Iyama, Kohichi Takada, Koji Miyanishi, Junji Kato

    Oncotarget   9 ( 38 )   25127 - 25135   2018.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Impact Journals LLC  

    DOI： 10.18632/oncotarget.25350

    researchmap

  • Clostridium difficile肝膿瘍の1例 Reviewed

    松野 鉄平, 田中 信悟, 宮西 浩嗣, 河野 豊, 中村 元, 坂本 拡基, 早坂 尚貴, 石川 和真, 村瀬 和幸, 高田 弘一, 高梨 訓博, 勝木 伸一, 小船 雅義, 加藤 淳二

    肝臓   59 ( 3 )   180 - 186   2018.3

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • ART療法中に多発血栓症を併発した悪性リンパ腫患者の一例

    池田 博, 吉田 正宏, 舘越 鮎美, 菊地 尚平, 村瀬 和幸, 高田 弘一, 井山 諭, 小船 雅義, 村上 則子, 宮越 郁子, 又村 了輔, 國本 雄介, 加藤 淳二

    日本エイズ学会誌   19 ( 4 )   501 - 501   2017.11

    　More details

    Language：Japanese   Publisher：(一社)日本エイズ学会  

    Ichushi

    researchmap

  • Cardiac diffuse large B-cell lymphoma presenting with acute heart failure due to cardiac tamponade Reviewed

    Ken Sato, Hiroyuki Kuroda, Michiko Yamada, Saki Ameda, Shogo Miura, Hiroya Sakano, Takanori Shibata, Naoki Uemura, Tomoyuki Abe, Shigeyuki Fujii, Masahiro Maeda, Miri Fujita, Masayoshi Kobune, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   44 ( 10 )   875 - 879   2017.10

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    PubMed

    researchmap

  • Small molecule CP-31398 induces reactive oxygen species-dependent apoptosis in human multiple myeloma Reviewed

    Yohei Arihara, Kohichi Takada, Yusuke Kamihara, Naotaka Hayasaka, Hajime Nakamura, Kazuyuki Murase, Hiroshi Ikeda, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    ONCOTARGET   8 ( 39 )   65889 - 65899   2017.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.18632/oncotarget.19508

    PubMed

    Web of Science

    researchmap

  • Effective bird therapy after the addition of clarithromycin for lenalidomide and dexamethasone resistant multiple myeloma ineligible for stem cell transplantation

    Shogo Miura, Hiroyuki Kuroda, Michiko Yamada, Ken Sato, Saki Ameda, Hiroya Sakano, Takanori Shibata, Naoki Uemura, Tomoyuki Abe, Shigeyuki Fujii, Masahiro Maeda, Masayoshi Kobune, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   44 ( 8 )   689 - 693   2017.8

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    PubMed

    researchmap

  • Hepatitis C virus reactivation due to antiemetic steroid therapy during treatment of hepatocellular carcinoma Reviewed

    Yutaka Kawano, Koji Miyanishi, Satoshi Takahashi, Tomohiro Kubo, Kazuma Ishikawa, Shintaro Sugita, Kohichi Takada, Masayoshi Kobune, Tadashi Hasegawa, Junji Kato

    JOURNAL OF INFECTION AND CHEMOTHERAPY   23 ( 5-6 )   323 - 325   2017.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jiac.2016.12.008

    Web of Science

    researchmap

  • Iron overload patients with unknown etiology from national survey in Japan Reviewed

    Katsuya Ikuta, Mayumi Hatayama, Lynda Addo, Yasumichi Toki, Katsunori Sasaki, Yasuaki Tatsumi, Ai Hattori, Ayako Kato, Koichi Kato, Hisao Hayashi, Takahiro Suzuki, Masayoshi Kobune, Miyuki Tsutsui, Akihiko Gotoh, Yasuo Aota, Motoo Matsuura, Yuzuru Hamada, Takahiro Tokuda, Norio Komatsu, Yutaka Kohgo

    INTERNATIONAL JOURNAL OF HEMATOLOGY   105 ( 3 )   353 - 360   2017.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12185-016-2141-9

    PubMed

    Web of Science

    researchmap

  • 集学的治療により救命し得たClostridium perfringensによる肝膿瘍の2例 Reviewed

    久保 智洋, 河野 豊, 宮西 浩嗣, 石川 和真, 桜田 晃, 佐藤 昌則, 保木 寿文, 田村 文人, 田中 信悟, 高田 弘一, 小船 雅義, 加藤 淳二

    肝臓   58 ( 2 )   105 - 114   2017.2

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • A Multicenter Retrospective Study of Mogamulizumab Efficacy in Adult T-Cell Leukemia/Lymphoma Reviewed

    Satoshi Iyama, Tsutomu Sato, Hirofumi Ohnishi, Yuji Kanisawa, Shuichi Ohta, Takeshi Kondo, Akio Mori, Yutaka Tsutsumi, Hiroyuki Kuroda, Yasutaka Kakinoki, Satoshi Yamamoto, Tohru Takahashi, Motohiro Shindo, Yoshihiro Torimoto, Kazuya Sato, Hiroshi Iwasaki, Yoshihito Haseyama, Kyuhei Kohda, Yasuhiro Nagamachi, Yasuo Hirayama, Hajime Sakai, Yasuji Hirata, Takashi Fukuhara, Hiroshi Ikeda, Masayoshi Kobune, Junji Kato, Mitsutoshi Kurosawa

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   17 ( 1 )   23 - 30   2017.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.clml.2016.09.009

    PubMed

    Web of Science

    researchmap

  • Thrombotic microangiopathy due to malignant hypertension complicated with late-onset bleeding after renal biopsy

    AMEDA Saki, KURODA Hiroyuki, YAMADA Michiko, SATO Ken, MIURA Shogo, SAKANO Hiroya, SHIBATA Takanori, UEMURA Naoki, ABE Tomoyuki, FUJII Shigeyuki, MAEDA Masahiro, FUJITA Miri, KOBUNE Masayoshi, KATO Junji

    Rinsho Ketsueki   58 ( 6 )   637 - 642   2017

    　More details

    Language：Japanese   Publisher：The Japanese Society of Hematology  

    <p>A 47-year-old man presented at a local ophthalmological hospital with blurred vision. He had been diagnosed with hypertensive retinopathy and renal failure and was referred to our hospital for treatment. A renal biopsy was done to evaluate pathology of high proteinuria, hematuria, and rapidly progressive glomerulonephritis. Blood pressure remained high despite antihypertensive therapy; anemia and thrombocytopenia gradually progressed. Thrombotic microangiopathy (TMA) was suspected based on red blood cell fragmentation due to hemolytic anemia, thrombocytopenia, and renal failure. However, plasma exchange resolved neither thrombocytopenia nor renal failure, and anemia gradually progressed. Backache suddenly developed 13 days later, and CT findings indicated a retroperitoneal hematoma secondary to bleeding from the kidney. Selective renal artery embolization via angiography stopped the bleeding, but the patient went into hemorrhagic shock. Pathological findings on renal biopsy were identical to those in malignant hypertension, namely an edematous membrane lining, thickened arterioles, and stenosis. We diagnosed thrombotic microangiopathy due to malignant hypertension, without decrease in activities of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif) or its antibodies. Renal failure did not improve, and continuous hemodiafiltration was needed. This procedure stabilized blood pressure and improved the TMA.</p>

    Other Link： http://search.jamas.or.jp/link/ui/2017370561

    DOI： 10.11406/rinketsu.58.637

    researchmap

  • Two cases of liver abscess caused by clostridium perfringens that potentially cured by combined modality therapy Reviewed

    Tomohiro Kubo, Yutaka Kawano, Kouji Miyanishi, Kazuma Ishikawa, Akira Sakurada, Masanori Sato, Toshifumi Hoki, Fumito Tamura, Singo Tanaka, Kouichi Takada, Masayoshi Kobune, Junji Kato

    Acta Hepatologica Japonica   58 ( 2 )   105 - 114   2017

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Society of Hepatology  

    DOI： 10.2957/KANZO.58.105

    researchmap

  • Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells Reviewed

    Yutaka Okagawa, Kohichi Takada, Yohei Arihara, Shohei Kikuchi, Takahiro Osuga, Hajime Nakamura, Yusuke Kamihara, Naotaka Hayasaka, Makoto Usami, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    PLOS ONE   11 ( 12 )   2016.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0168355

    Web of Science

    researchmap

  • A phase II trial of small-dose bortezomib, lenalidomide and dexamethasone (sVRD) as consolidation/maintenance therapy in patients with multiple myeloma Reviewed

    Soushi Ibata, Tsutomu Sato, Hiroyuki Kuroda, Yasuhiro Nagamachi, Satoshi Iyama, Akihito Fujimi, Yusuke Kamihara, Yuichi Konuma, Masahiro Yoshida, Ayumi Tatekoshi, Akari Hashimoto, Hiroto Horiguchi, Kaoru Ono, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Masayoshi Kobune, Yasuo Hirayama, Junji Kato

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   78 ( 5 )   1041 - 1049   2016.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00280-016-3163-y

    PubMed

    Web of Science

    researchmap

  • The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma. Reviewed International journal

    Yusuke Kamihara, Kohichi Takada, Tsutomu Sato, Yutaka Kawano, Kazuyuki Murase, Yohei Arihara, Shohei Kikuchi, Naotaka Hayasaka, Makoto Usami, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune, Junji Kato

    Oncotarget   7 ( 39 )   64330 - 64341   2016.9

    　More details

    Language：English  

    Deregulated iron metabolism underlies the pathogenesis of many human cancers. Recently, low expression of ferroportin, which is the only identified non-heme iron exporter, has been associated with significantly reduced overall survival in multiple myeloma (MM); however, the altered iron metabolism in MM biology remains unclear. In this study we demonstrated, by live cell imaging, that MM cells have increased intracellular iron levels as compared with normal cells. In experiments to test the effect of iron chelation on the growth of MM cells, we found that deferasirox (DFX), an oral iron chelator used to treat iron overload in clinical practice, inhibits MM cell growth both in vivo and in vitro. Mechanistically, DFX was found to induce apoptosis of MM cells via the inhibition of proline-rich tyrosine kinase 2 (Pyk2), which is known to promote tumor growth in MM. Inhibition of Pyk2 is caused by the suppression of reactive oxygen species, and leads to downregulation of the Wnt/β-catenin signaling pathway. Taken together, our findings indicate that high levels of intracellular iron, which might be due to low ferroportin expression, play a role in MM pathophysiology. Therefore, DFX may provide a therapeutic option for MM that is driven by deregulated iron homeostasis and/or Pyk2/Wnt signaling.

    DOI： 10.18632/oncotarget.11830

    PubMed

    researchmap

  • Relationship Between Increased Fucosylation and Metastatic Potential in Colorectal Cancer Reviewed

    Takahiro Osuga, Rishu Takimoto, Michihiro Ono, Masahiro Hirakawa, Makoto Yoshida, Yutaka Okagawa, Naoki Uemura, Yohei Arihara, Yasushi Sato, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Masayoshi Kobune, Junji Kato

    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE   108 ( 9 )   2016.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/jnci/djw210

    PubMed

    Web of Science

    researchmap

  • Targeting Notch-1 positive acute leukemia cells by novel fucose-bound liposomes carrying daunorubicin Reviewed

    Michihiro Ono, Rishu Takimoto, Takahiro Osuga, Yutaka Okagawa, Masahiro Hirakawa, Makoto Yoshida, Yohei Arihara, Naoki Uemura, Naoki Hayasaka, Shogo Miura, Teppei Matsuno, Fumito Tamura, Yasushi Sato, Tsutomu Sato, Satoshi Iyama, Koji Miyanishi, Kohichi Takada, Masayoshi Kobune, Junji Kato

    ONCOTARGET   7 ( 25 )   38586 - 38597   2016.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.18632/oncotarget.9558

    PubMed

    Web of Science

    researchmap

  • Isoform D of vascular endothelial growth factor in systemic capillary leak syndrome: a case report. Reviewed International journal

    Soushi Ibata, Tsutomu Sato, Kohichi Takada, Ayumi Tatekoshi, Akari Hashimoto, Yusuke Kamihara, Wataru Jomen, Hiroto Horiguchi, Kaoru Ono, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    Journal of medical case reports   10   125 - 125   2016.5

    　More details

    Language：English  

    BACKGROUND: Systemic capillary leak syndrome is a rare condition characterized by episodic attacks of hypovolemia due to systemic capillary hyperpermeability, which results in profound hypotension and edema. Although the implication of vascular endothelial growth factor, angiopoietin-2, and C-X-C motif chemokine 10 has been suggested, the pathogenesis of systemic capillary leak syndrome remains unclear. In this report, we describe a case of systemic capillary leak syndrome in which serum isoform D of vascular endothelial growth factor was elevated. To the best of our knowledge, this is the first reported case of systemic capillary leak syndrome in which isoform D of vascular endothelial growth factor is suggested as the plausible biomarker. CASE PRESENTATION: A 41-year-old Japanese man was transferred to our emergency department. He was hypotensive, tachycardic, and edematous over the trunk and all four limbs. He received aggressive intravenous fluid therapy and underwent fasciotomy of the right forearm to prevent muscle necrosis. A diagnosis of systemic capillary leak syndrome was suspected. The presence of serum monoclonal immunoglobulin G and κ light chain supported this diagnosis. Prevention of hypotensive crises was unsuccessfully attempted with theophylline, intravenous immunoglobulin, high-dose dexamethasone, bortezomib, melphalan, and prednisolone; however, the patient's attacks dramatically disappeared after the introduction of thalidomide. The serum of the patient was stored soon after the onset of hypotensive crisis and analyzed to profile possible mediators responsible for the capillary leak. The concentration of vascular endothelial growth factor, angiopoietin-2, and C-X-C motif chemokine 10 were all within normal ranges. Meanwhile, we found that isoform D of vascular endothelial growth factor was elevated, which was normalized after the introduction of thalidomide. CONCLUSIONS: In our patient, isoform D of vascular endothelial growth factor (instead of vascular endothelial growth factor) may have been a causative factor of hypotensive crises, since isoform D contributes to vascular endothelial growth factor receptor-2 signaling, which is the major mediator of the permeability-enhancing effects of vascular endothelial growth factor. We suggest the measurement of isoform D of vascular endothelial growth factor in patients with systemic capillary leak syndrome in whose serum vascular endothelial growth factor is not elevated.

    DOI： 10.1186/s13256-016-0894-7

    PubMed

    researchmap

  • Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms Reviewed

    Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Masahiro Yoshida, Masaki Murata, Kazuyuki Murase, Satoshi Iyama, Kohichi Takada, Tsutomu Sato, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yutaka Kawano, Koji Miyanishi, Norimasa Sawada, Junji Kato

    HAEMATOLOGICA   101 ( 4 )   437 - 447   2016.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3324/haematol.2015.134932

    PubMed

    Web of Science

    researchmap

  • Narrow-Band Ultraviolet B Phototherapy Ameliorates Acute Graft-Versus-Host Disease of the Intestine by Expansion of Regulatory T Cells. Reviewed

    Hashimoto A, Sato T, Iyama S, Yoshida M, Ibata S, Tatekoshi A, Kamihara Y, Horiguchi H, Murase K, Kawano Y, Takada K, Miyanishi K, Kobune M, Ichimiya S, Kato J

    PloS one   11 ( 3 )   e0152823   2016.3

    　More details

  • RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells Reviewed

    Fumito Tamura, Yasushi Sato, Masahiro Hirakawa, Makoto Yoshida, Michihiro Ono, Takahiro Osuga, Yutaka Okagawa, Naoki Uemura, Yohei Arihara, Kazuyuki Murase, Yutaka Kawano, Satoshi Iyama, Kohichi Takada, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    GASTRIC CANCER   19 ( 1 )   85 - 97   2016.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10120-014-0454-z

    PubMed

    Web of Science

    researchmap

  • [Neurolymphomatosis of the sciatic nerve diagnosed by FDG-PET/CT]. Reviewed

    Usami M, Murase K, Takada K, Iijima K, Yoshida M, Tatekoshi A, Hashimoto A, Iyama S, Sato T, Kobune M, Takimoto R, Kaya M, Yamashita T, Morita R, Hasegawa T, Kato J

    [Rinsho ketsueki] The Japanese journal of clinical hematology   57 ( 1 )   52 - 55   2016.1

    　More details

  • 集学的治療により救命し得たClostridium perfringens感染症による肝膿瘍の2例 Reviewed

    久保 智洋, 宮西 浩嗣, 河野 豊, 桜田 晃, 石川 和真, 佐藤 昌則, 保木 寿文, 高田 弘一, 佐藤 康史, 瀧本 理修, 小船 雅義, 加藤 淳二

    肝臓   56 ( Suppl.3 )   A1063 - A1063   2015.11

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • 肝生検で高分化型肝細胞癌との鑑別が困難であった多発肝細胞腺腫の1切除例 Reviewed

    田村 文人, 河野 豊, 宮西 浩嗣, 久保 智洋, 神原 悠輔, 岡川 泰, 石川 和真, 高田 弘一, 林 毅, 佐藤 勉, 佐藤 康史, 小船 雅義, 瀧本 理修, 川本 雅樹, 目黒 誠, 水口 徹, 荻野 次郎, 長谷川 匡, 米田 憲秀, 佐々木 素子, 加藤 淳二

    肝臓   56 ( 11 )   584 - 595   2015.11

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • BAK is a predictive and prognostic biomarker for the therapeutic effect of docetaxel treatment in patients with advanced gastric cancer. Reviewed

    Kubo T, Kawano Y, Himuro N, Sugita S, Sato Y, Ishikawa K, Takada K, Murase K, Miyanishi K, Sato T, Takimoto R, Kobune M, Nobuoka T, Hirata K, Takayama T, Mori M, Hasegawa T, Kato J

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   19 ( 3 )   827 - 838   2015.10

    　More details

  • A Phase 1/2 Study of Definitive Chemoradiation Therapy Using Docetaxel, Nedaplatin, and 5-Fluorouracil (DNF-R) for Esophageal Cancer Reviewed

    Hiroyuki Ohnuma, Yasushi Sato, Masahiro Hirakawa, Yutaka Okagawa, Takahiro Osuga, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Tamotsu Sagawa, Masakazu Hori, Masanori Someya, Kensei Nakata, Koh-ichi Sakata, Tetsuji Takayama, Junji Kato

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   93 ( 2 )   382 - 390   2015.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ijrobp.2015.05.041

    PubMed

    Web of Science

    researchmap

  • Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial Reviewed

    Yasuo Hirayama, Kunihiko Ishitani, Yasushi Sato, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Hiroyuki Kuroda, Yasuhiro Nagamachi, Yuichi Konuma, Akihito Fujimi, Tamotsu Sagawa, Kaoru Ono, Hiroto Horiguchi, Takeshi Terui, Kazuhiko Koike, Toshiro Kusakabe, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   20 ( 5 )   866 - 871   2015.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10147-015-0810-y

    PubMed

    Web of Science

    researchmap

  • Increased duodenal iron absorption through up-regulation of divalent metal transporter 1 from enhancement of iron regulatory protein 1 activity in patients with nonalcoholic steatohepatitis Reviewed

    Toshifumi Hoki, Koji Miyanishi, Shingo Tanaka, Kohichi Takada, Yutaka Kawano, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    HEPATOLOGY   62 ( 3 )   751 - 761   2015.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/hep.27774

    PubMed

    Web of Science

    researchmap

  • Trastuzumab in combination with docetaxel/cisplatin/S-1 (DCS) for patients with HER2-positive metastatic gastric cancer: feasibility and preliminary efficacy Reviewed

    Yasuhiro Mitsui, Yasushi Sato, Hiroshi Miyamoto, Yasuteru Fujino, Toshi Takaoka, Jinsei Miyoshi, Miwako Kagawa, Hiroyuki Ohnuma, Masahiro Hirakawa, Tomohiro Kubo, Takahiro Osuga, Tamotsu Sagawa, Yasuhiro Sato, Yasuo Takahashi, Shinich Katsuki, Toshinori Okuda, Rishu Takimoto, Masayoshi Kobune, Takayuki Nobuoka, Koichi Hirata, Junji Kato, Tetsuji Takayama

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   76 ( 2 )   375 - 382   2015.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00280-015-2807-7

    PubMed

    Web of Science

    researchmap

  • A long-term survival case of hepatic epithelioid hemangioendothelioma with lung metastases treated with recombinant interleukin-2 Reviewed

    Toshifumi Hoki, Koji Miyanishi, Yutaka Kawano, Shota Yamada, Kohei Harada, Masahiro Hirakawa, Fumito Tamura, Kazuma Ishikawa, Kohichi Takada, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Tadashi Hasegawa, Junji Kato

    Acta Hepatologica Japonica   56 ( 7 )   356 - 365   2015.7

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Society of Hepatology  

    DOI： 10.2957/kanzo.56.356

    researchmap

  • A case of fanconi syndrome induced by zoledronic acid in a metastatic colorectal cancer patient Reviewed

    Yutaka Okagawa, Yasushi Sato, Hiroyuki Onuma, Takahiro Osuga, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   42 ( 7 )   867 - 870   2015.7

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    PubMed

    researchmap

  • Recombinant interleukin-2を投与し6年間経過観察している肺転移を伴う肝類上皮血管内皮腫の1例 Reviewed

    保木 寿文, 宮西 浩嗣, 河野 豊, 山田 尚太, 原田 耕平, 平川 昌宏, 田村 文人, 石川 和真, 高田 弘一, 佐藤 勉, 佐藤 康史, 瀧本 理修, 小船 雅義, 長谷川 匡, 加藤 淳二

    肝臓   56 ( 7 )   356 - 365   2015.7

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • Phase I trial of oral S-1 combined with hepatic arterial infusion of gemcitabine in unresectable biliary tract cancer Reviewed

    Hirotoshi Ishiwatari, Tsuyoshi Hayashi, Makoto Yoshida, Michihiro Ono, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   75 ( 4 )   805 - 812   2015.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00280-015-2704-0

    PubMed

    Web of Science

    researchmap

  • A dose-escalation study of oxaliplatin/capecitabine/irinotecan (XELOXIRI) and bevacizumab as a first-line therapy for patients with metastatic colorectal cancer Reviewed

    Yasushi Sato, Hiroyuki Ohnuma, Masahiro Hirakawa, Minoru Takahashi, Takahiro Osuga, Yutaka Okagawa, Kazuyuki Murase, Kohichi Takada, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Kenji Okita, Toru Mizuguchi, Tomohisa Furuhata, Koichi Hirata, Junji Kato

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   75 ( 3 )   587 - 594   2015.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00280-014-2672-9

    PubMed

    Web of Science

    researchmap

  • EUS-guided celiac plexus neurolysis by using highly viscous phenol-glycerol as a neurolytic agent Reviewed

    Hirotoshi Ishiwatari, Tsuyoshi Hayashi, Makoto Yoshida, Michihiro Ono, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Hiroyuki Masuko, Atsushi Miyamoto, Tomoko Sonoda, Junji Kato

    GASTROINTESTINAL ENDOSCOPY   81 ( 2 )   479 - 483   2015.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.gie.2014.10.031

    PubMed

    Web of Science

    researchmap

  • A CASE OF DUODENAL BRUNNER'S GLAND HAMARTOMA IN WHICH MAGNIFYING ENDOSCOPY WAS USEFUL FOR PREOPERATIVE DIAGNOSIS

    OSUGA Takahiro, SATO Yasushi, ISHIKAWA Kazuma, ONUMA Hiroyuki, OKAGAWA Yutaka, SUGITA Shintarou, AKIYAMA Takehide, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji

    Gastroenterological Endoscopy   57 ( 10 )   2441 - 2447   2015

    　More details

    Language：Japanese   Publisher：Japan Gastroenterological Endoscopy Society  

    A 70-year-old man was referred to our hospital to treat a polyp in the duodenal bulb. Endoscopic examination showed that the polyp was composed of Yamada type IV lesions with thick stems and a head that was reddish. Magnifying endoscopy revealed a small opening and gastric epithelial metaplasia in the head of the polyp. We performed polypectomy for therapeutic diagnosis. Histologically, the lesion was a duodenal Brunner's gland hamartoma with abundant mature adipose tissue and gastric metaplasia. Brunner's gland hamartoma is composed of hyperplastic Brunner's glands mixed with elements such as adipose tissue, and is often accompanied by gastric epithelial metaplasia. Because diagnosis by biopsy is not possible, preoperative diagnosis of the disease is difficult. However, magnifying endoscopy enabled us to detect some characteristic findings of the disease, such as a small opening and gastric epithelial metaplasia. As a result, preoperative diagnosis might be possible by magnifying endoscopy. This case suggested that magnifying endoscopy is useful for the diagnosis of Brunner's gland hamartoma.

    Other Link： http://search.jamas.or.jp/link/ui/2016053313

    DOI： 10.11280/gee.57.2441

    researchmap

  • Markers of bone metabolism in multiple myeloma patients switched from zoledronic acid to denosumab. Reviewed

    Tatekoshi A, Sato T, Ibata S, Hashimoto A, Kamihara Y, Horiguchi H, Ono K, Takada K, Iyama S, Takimoto R, Kobune M, Kato J

    [Rinsho ketsueki] The Japanese journal of clinical hematology   55 ( 11 )   2271 - 2276   2014.11

    　More details

  • Efficacy of Enteral Supplementation Enriched with Glutamine, Fiber, and Oligosaccharide on Mucosal Injury following Hematopoietic Stem Cell Transplantation. Reviewed

    Iyama S, Sato T, Tatsumi H, Hashimoto A, Tatekoshi A, Kamihara Y, Horiguchi H, Ibata S, Ono K, Murase K, Takada K, Sato Y, Hayashi T, Miyanishi K, Akizuki E, Nobuoka T, Mizugichi T, Takimoto R, Kobune M, Hirata K, Kato J

    Case reports in oncology   7 ( 3 )   692 - 699   2014.9

    　More details

  • Phenol-based endoscopic ultrasound-guided celiac plexus neurolysis for East Asian alcohol-intolerant upper gastrointestinal cancer patients: A pilot study Reviewed

    Hirotoshi Ishiwatari, Tsuyoshi Hayashi, Makoto Yoshida, Michihiro Ono, Hiroyuki Masuko, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Atsushi Miyamoto, Tomoko Sonoda, Junji Kato

    WORLD JOURNAL OF GASTROENTEROLOGY   20 ( 30 )   10512 - 10517   2014.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3748/wjg.v20.i30.10512

    PubMed

    Web of Science

    researchmap

  • [Effective treatment of metastatic rhabdomyosarcoma with pazopanib]. Reviewed

    Hashimoto A, Takada K, Takimoto R, Horiguchi H, Sato T, Iyama S, Murase K, Ono K, Tatekoshi A, Hayashi T, Miyanishi K, Sato Y, Kobune M, Hirayama Y, Kitamura H, Nakanishi K, Masumori N, Hasegawa T, Kato J

    Gan to kagaku ryoho. Cancer & chemotherapy   41 ( 8 )   1041 - 1044   2014.8

    　More details

  • Radiation-induced leiomyosarcoma of the prostate after brachytherapy for prostatic adenocarcinoma. Reviewed

    Horiguchi H, Takada K, Kamihara Y, Ibata S, Iyama S, Sato T, Hayashi T, Miyanishi K, Sato Y, Takimoto R, Kobune M, Kobayashi K, Hirayama Y, Masumori N, Hasegawa T, Kato J

    Case reports in oncology   7 ( 2 )   565 - 570   2014.5

    　More details

  • Combination Chemotherapy of Azacitidine and Cetuximab for Therapy-Related Acute Myeloid Leukemia following Oxaliplatin for Metastatic Colorectal Cancer. Reviewed

    Hashimoto A, Takada K, Horiguchi H, Sato T, Iyama S, Murase K, Kamihara Y, Ono K, Tatekoshi A, Hayashi T, Miyanishi K, Sato Y, Furuhata T, Kobune M, Takimoto R, Hirata K, Kato J

    Case reports in oncology   7 ( 2 )   316 - 322   2014.5

    　More details

  • Narrowband ultraviolet B phototherapy ameliorates acute graft-versus-host disease by a mechanism involving in vivo expansion of CD4+CD25+Foxp3+regulatory T cells Reviewed

    Satoshi Iyama, Kazuyuki Murase, Tsutomu Sato, Akari Hashimoto, Ayumi Tatekoshi, Hiroto Horiguchi, Yusuke Kamihara, Kaoru Ono, Shohei Kikuchi, Kohichi Takada, Yutaka Kawano, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Satoru Mori, Junji Kato, Toshiharu Yamashita, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   99 ( 4 )   471 - 476   2014.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12185-014-1530-1

    PubMed

    Web of Science

    researchmap

  • アデホビル長期投与中にFanconi症候群による低リン血性骨軟化症を発症したB型慢性肝炎の1例 Reviewed

    石川 和真, 宮西 浩嗣, 保木 寿文, 田村 文人, 河野 豊, 高田 弘一, 田中 信悟, 櫻田 晃, 佐藤 康史, 佐藤 勉, 林 毅, 瀧本 理修, 小船 雅義, 加藤 淳二

    肝臓   55 ( 3 )   162 - 169   2014.3

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • A novel strategy inducing autophagic cell death in Burkitt's lymphoma cells with anti-CD19-targeted liposomal rapamycin Reviewed

    K. Ono, T. Sato, S. Iyama, A. Tatekoshi, A. Hashimoto, Y. Kamihara, H. Horiguchi, S. Kikuchi, Y. Kawano, K. Takada, T. Hayashi, K. Miyanishi, Y. Sato, R. Takimoto, M. Kobune, J. Kato

    BLOOD CANCER JOURNAL   4   2014.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/bcj.2014.2

    Web of Science

    researchmap

  • Fucosylated TGF-beta receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells Reviewed

    M. Hirakawa, R. Takimoto, F. Tamura, M. Yoshida, M. Ono, K. Murase, Y. Sato, T. Osuga, T. Sato, S. Iyama, K. Miyanishi, K. Takada, T. Hayashi, M. Kobune, J. Kato

    BRITISH JOURNAL OF CANCER   110 ( 1 )   156 - 163   2014.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/bjc.2013.699

    Web of Science

    researchmap

  • Pancreatic metastasis from a solitary fibrous tumor of the central nervous system Reviewed

    Takahiro Osuga, Tsuyoshi Hayashi, Hirotoshi Ishiwatari, Michihiro Ono, Makoto Yoshida, Yasutoshi Kimura, Tadashi Hasegawa, Yasushi Sato, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    Journal of the Pancreas   15 ( 1 )   58 - 62   2014.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：1  

    PubMed

    researchmap

  • A case of acquired fanconi's syndrome and hypophosphatemic osteomalacia induced by prolonged adefovir therapy for chronic hepatitis B Reviewed

    Kazuma Ishikawa, Koji Miyanishi, Toshifumi Hoki, Fumito Tamura, Yutaka Kawano, Kohichi Takada, Shingo Tanaka, Akira Sakurada, Yasushi Sato, Tsutomu Sato, Tsuyoshi Hayashi, Risyu Takimoto, Masayoshi Kobune, Junji Kato

    Acta Hepatologica Japonica   55 ( 3 )   162 - 169   2014

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.2957/kanzo.55.162

    researchmap

  • Successful Treatment with Entecavir for Reactivation of Hepatitis B Virus Following Systemic Chemotherapy in a Hepatitis B Surface Antigen-negative Patient with Colorectal Cancer Reviewed

    Yutaka Okagawa, Kohichi Takada, Hiroyuki Hisai, Yutaka Koshiba, Hironori Wada, Etsu Miyazaki, Yusuke Kanari, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    INTERNAL MEDICINE   53 ( 16 )   1759 - 1762   2014

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2169/internalmedicine.53.1970

    PubMed

    Web of Science

    researchmap

  • Increased hepatic oxidative DNA damage in patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. Reviewed

    Tanaka S, Miyanishi K, Kobune M, Kawano Y, Hoki T, Kubo T, Hayashi T, Sato T, Sato Y, Takimoto R, Kato J

    Journal of gastroenterology   48 ( 11 )   1249 - 1258   2013.11

    　More details

  • Diagnostic validity of CT gastrography versus gastroscopy for primary lesions in gastric cancer: evaluating the response to chemotherapy, a retrospective analysis. Reviewed

    Sho Takahashi, Michiaki Hirayama, Ganji Kuroiwa, Yutaka Kawano, Kohichi Takada, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   16 ( 4 )   543 - 8   2013.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: This retrospective study was carried out to compare computed tomographic (CT) gastrography and conventional optical gastroscopy (GS) in order to evaluate the effectiveness of chemotherapy in primary gastric lesions. METHODS: Patients with unresectable advanced and unresected early gastric cancer who had primary lesions and had received chemotherapy were enrolled. For primary lesions, CT gastrography and endoscopic assessment were done after chemotherapy, based on the Japanese Classification of Gastric Carcinoma (JCGC) criteria, 13th edition, and the Response Evaluation Criteria in Solid Tumors (RECIST). For metastatic solid lesions including lymph nodes, CT assessment was done based on the RECIST criteria. RESULTS: Data from 23 patients were analyzed. With median follow-up of 9.4 months (range 2-23 months), 58 examinations were assessed by GS and CT gastrography. Setting optical endoscopic results as the gold standard, the accuracy of CT gastrography for primary gastric lesions was 77.6 % (45 of 58) (weighted κ = 0.72; P < 0.01) according to the JCGC 13th edition criteria and 90.0 % (52 of 58) (weighted κ = 0.75; P < 0.01) according to the RECIST. When all results were divided into two groups [the non-progressive disease (non-PD) group and PD group], accuracy was 93.1 % (52 of 58) (κ = 0.81; P < 0.01), sensitivity was 100 %, and specificity was 75.0 % (12 of 16). In addition, the predictability of PD was 100 % (12 of 12). The four cases of failure in specification were the following: a case of gastric remnant cancer, a case with insufficient distension of the stomach, a healed case with stenosis and scarring, and a case in which the wrong position had been selected for the examination. The average period until PD was 9.9 months (range 5-18 months), and the concordance period between GS and CT gastrography was 7.2 months in both non-PD and PD cases. CONCLUSIONS: There was good concordance between the evaluations of GS and CT gastrography. CT gastrography exhibited favorable results in accuracy as well as 100 % PD predictability, which implied the possibility of using CT gastrography as a substitute for endoscopic assessments at post-chemotherapy assessments.

    DOI： 10.1007/s10120-012-0217-7

    PubMed

    researchmap

  • Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes. Reviewed

    Ishiwatari H, Sato Y, Murase K, Yoneda A, Fujita R, Nishita H, Birukawa NK, Hayashi T, Sato T, Miyanishi K, Takimoto R, Kobune M, Ota S, Kimura Y, Hirata K, Kato J, Niitsu Y

    Gut   62 ( 9 )   1328 - 1339   2013.9

    　More details

  • ASH、NASHの最前線 アルコール性肝障害および非アルコール性脂肪肝炎からの発癌における酸化ストレスの関与についての検討 Reviewed

    田中 信悟, 宮西 浩嗣, 河野 豊, 保木 寿文, 久保 智洋, 高田 弘一, 林 毅, 佐藤 勉, 佐藤 康史, 小船 雅義, 瀧本 理修, 加藤 淳二

    肝臓   54 ( Suppl.1 )   A70 - A70   2013.4

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • A phase II study of neoadjuvant combination chemotherapy with docetaxel, cisplatin, and S-1 for locally advanced resectable gastric cancer: nucleotide excision repair (NER) as potential chemoresistance marker Reviewed

    Masahiro Hirakawa, Yasushi Sato, Hiroyuki Ohnuma, Tetsuji Takayama, Tamotsu Sagawa, Takayuki Nobuoka, Keisuke Harada, Hiroshi Miyamoto, Yasuhiro Sato, Yasuo Takahashi, Shinich Katsuki, Michiaki Hirayama, Minoru Takahashi, Michihiro Ono, Masahiro Maeda, Kohichi Takada, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Koichi Hirata, Junji Kato

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   71 ( 3 )   789 - 797   2013.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00280-013-2073-5

    PubMed

    Web of Science

    researchmap

  • Rapid on-site evaluation by endosonographer during endoscopic ultrasound-guided fine needle aspiration for pancreatic solid masses Reviewed

    Tsuyoshi Hayashi, Hirotoshi Ishiwatari, Makoto Yoshida, Michihiro Ono, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Tomoko Mitsuhashi, Hiroko Asanuma, Jiro Ogino, Tadashi Hasegawa, Tomoko Sonoda, Junji Kato

    Journal of Gastroenterology and Hepatology (Australia)   28 ( 4 )   656 - 663   2013

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Blackwell Publishing  

    DOI： 10.1111/jgh.12122

    PubMed

    researchmap

  • A case of hemosiderin deposition associated with hepatic graft-versus-host disease after peripheral blood stem cell transplantation for acute lymphocytic leukemia

    Jomen Wataru, Kuroda Hiroyuki, Arihara Yohei, Yamada Michiko, Hirako Tasuku, Abe Tomoyuki, Sakurai Tamaki, Fujii Shigeyuki, Maeda Masahiro, Fujita Miri, Nagashima Kazuo, Iyama Satoshi, Miyanishi Koji, Kobune Masayoshi, Kato Junji

    Kanzo   54 ( 11 )   741 - 747   2013

    　More details

    Language：Japanese   Publisher：The Japan Society of Hepatology  

    A 57-year-old woman was diagnosed with acute lymphocytic leukemia (ALL) in July 2009. After complete remission, she received allogenic peripheral blood stem cell transplantation (allo-PBSCT). She had had hepatic dysfunction and high serum ferritin level since February 2011. The hepatic dysfunction had continued even after administration of ursodeoxycholic acid and bezafibrate. The findings of liver biopsy suggested Graft-versus-Host Disease (GVHD) associated with hemosiderin deposition and also 8-OHdG was strongly stained on the nuclei of hepatocytes and bile duct epithelium. The hepatic dysfunction and serum ferritin level normalized after administration of cyclosporine (CsA). The second liver biopsy showed the significant improvement of the findings of GVHD and hemosiderin deposition. These findings might suggest that hemosiderin deposition was associated with hepatic GVHD.

    Other Link： https://jlc.jst.go.jp/DN/JALC/10026812839?from=CiNii

    DOI： 10.2957/kanzo.54.741

    researchmap

  • A phase I trial of arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for unresectable biliary tract cancer Reviewed

    Tsuyoshi Hayashi, Hirotoshi Ishiwatari, Makoto Yoshida, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Tomoko Sonoda, Junji Kato

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   17 ( 5 )   491 - 497   2012.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10147-011-0320-5

    PubMed

    Web of Science

    researchmap

  • 非アルコール性脂肪性肝炎に細胆管細胞癌と肝細胞癌を合併した1例 Reviewed

    河野 豊, 菊地 尚平, 宮西 浩嗣, 永島 裕之, 平川 昌宏, 田村 文人, 吉田 真誠, 高橋 祥, 高田 弘一, 林 毅, 佐藤 勉, 佐藤 康史, 瀧本 理修, 小船 雅義, 川本 雅樹, 水口 徹, 平田 公一, 長谷川 匡, 加藤 淳二

    肝臓   53 ( 10 )   615 - 623   2012.10

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • Intermittent administration of recombinant human soluble thrombomodulin successfully controlled chronic disseminated intravascular coagulation in a patient with dissecting aortic aneurysm on an outpatient basis Reviewed

    Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Yusuke Kamihara, Kaoru Ono, Shohei Kikuchi, Kohichi Takada, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    BLOOD COAGULATION & FIBRINOLYSIS   23 ( 6 )   548 - 550   2012.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/MBC.0b013e32835510d6

    PubMed

    Web of Science

    researchmap

  • Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms Reviewed

    M. Kobune, S. Iyama, S. Kikuchi, H. Horiguchi, T. Sato, K. Murase, Y. Kawano, K. Takada, K. Ono, Y. Kamihara, T. Hayashi, K. Miyanishi, Y. Sato, R. Takimoto, J. Kato

    BLOOD CANCER JOURNAL   2   2012.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/bcj.2012.36

    Web of Science

    researchmap

  • NASHからの発癌における酸化的DNA傷害の関与についての検討 Reviewed

    田中 信悟, 宮西 浩嗣, 河野 豊, 林 毅, 佐藤 勉, 佐藤 康史, 小船 雅義, 瀧本 理修, 加藤 淳二

    肝臓   53 ( Suppl.2 )   A708 - A708   2012.9

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • Improvement of iron-mediated oxidative DNA damage in patients with transfusion-dependent myelodysplastic syndrome by treatment with deferasirox Reviewed

    Shohei Kikuchi, Masayoshi Kobune, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Yutaka Kawano, Kohichi Takada, Kaoru Ono, Yumiko Kaneko, Koji Miyanishi, Yasushi Sato, Tsuyoshi Hayashi, Rishu Takimoto, Junji Kato

    FREE RADICAL BIOLOGY AND MEDICINE   53 ( 4 )   643 - 648   2012.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.freeradbiomed.2012.06.006

    PubMed

    Web of Science

    researchmap

  • Targeting Anticancer Drug Delivery to Pancreatic Cancer Cells Using a Fucose-Bound Nanoparticle Approach Reviewed

    Makoto Yoshida, Rishu Takimoto, Kazuyuki Murase, Yasushi Sato, Masahiro Hirakawa, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Takahiro Osuga, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Masayoshi Kobune, Junji Kato

    PLOS ONE   7 ( 7 )   e39545   2012.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0039545

    PubMed

    Web of Science

    researchmap

  • Prognostic significance of serum ferritin level at diagnosis in myelodysplastic syndrome Reviewed

    Shohei Kikuchi, Masayoshi Kobune, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Yutaka Kawano, Kohichi Takada, Kaoru Ono, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   95 ( 5 )   527 - 534   2012.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12185-012-1048-3

    PubMed

    Web of Science

    researchmap

  • Successful Treatment by Fibrin Glue Sealant for Pneumothorax with Chronic GVHD Resistant to Autologous Blood Patch Pleurodesis Reviewed

    Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Shohei Kikuchi, Yusuke Kamihara, Kaoru Ono, Kohichi Takada, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Takuro Obama, Masahiro Miyajima, Atsushi Watanabe, Tetsuya Higami, Yasuo Hirayama, Junji Kato

    INTERNAL MEDICINE   51 ( 15 )   2011 - 2014   2012

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2169/internalmedicine.51.7355

    PubMed

    Web of Science

    researchmap

  • A case of pancreatic abscess associated with colonic fistula successfully treated by endoscopic transgastric drainage using a metallic stent Reviewed

    Hirotoshi Ishiwatari, Tsuyoshi Hayashi, Makoto Yoshida, Wataru Jomen, Koji Miyanishi, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    Clinical Journal of Gastroenterology   4 ( 5 )   331 - 335   2011.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12328-011-0249-2

    researchmap

  • A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine

    TAKAHASHI Sho, SATO Yasushi, SAGAWA Tamotsu, TANAKA Shingo, MURASE Kazuyuki, TAKADA Kohichi, IYAMA Satoshi, SATO Tsutomu, TAKIMOTO Rishu, KOBUNE Masayoshi, KUROIWA Ganji, HIRAYAMA Michiaki, OKAMOTO Tetsuro, KATO Junji

    Nippon Shokakibyo Gakkai Zasshi   108 ( 8 )   1405 - 1412   2011.8

    　More details

    Language：Japanese   Publisher：The Japanese Society of Gastroenterology  

    A 64-year-old man had been admitted to a previous hospital because of melena and a diagnosis of ulcerative colitis (UC, pancolitis type) had been made. He had received prednisolone and 5-ASA but steroid-induced hyperamylasemia had developed. Prednisolone had been tapered and halted, but it had resulted in UC relapse and thrombocytopenia. Then, he was referred to our hospital due to severe melena with hypovolemic shock. However, he was also positive for CMV antigen. Thus, we attempted to treat him with ganciclovir for CMV and intravenous cyclosporine (CsA) for UC. According to his clinical course, a reduction of CsA blood concentration induced leukocytopenia. Myelodysplastic syndrome (MDS, RAEB-1) was then revealed after bone marrow biopsy. A high blood CsA concentration may cause the improvement of UC and MDS conditions.<br>

    DOI： 10.11405/nisshoshi.108.1405

    researchmap

  • Novel missense mutation in the TMPRSS6 gene in a Japanese female with iron-refractory iron deficiency anemia Reviewed

    Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Yusuke Kamihara, Kaoru Ono, Shohei Kikuchi, Kohichi Takada, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   94 ( 1 )   101 - 103   2011.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12185-011-0881-0

    PubMed

    Web of Science

    researchmap

  • Iron chelator deferasirox rescued mice from Fas-induced fulminant hepatitis Reviewed

    Tsutomu Sato, Masayoshi Kobune, Kazuyuki Murase, Yukari Kado, Tetsuro Okamoto, Shingo Tanaka, Shohei Kikuchi, Hiroyuki Nagashima, Yutaka Kawano, Kohichi Takada, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

    HEPATOLOGY RESEARCH   41 ( 7 )   660 - 667   2011.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1872-034X.2011.00821.x

    PubMed

    Web of Science

    researchmap

  • Establishment of a simple test for iron absorption from the gastrointestinal tract Reviewed

    Masayoshi Kobune, Koji Miyanishi, Kohichi Takada, Yutaka Kawano, Hiroyuki Nagashima, Shohei Kikuchi, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   93 ( 6 )   715 - 719   2011.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12185-011-0878-8

    PubMed

    Web of Science

    researchmap

  • Argon plasma coagulation treatment of hemorrhagic radiation proctopathy: the optimal settings for application and long-term outcome Reviewed

    Yasushi Sato, Tetsuji Takayama, Tamotsu Sagawa, Masahiro Hirakawa, Hiroyuki Ohnuma, Koji Miyanishi, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Koichi Okamoto, Hisashi Takeuchi, Junji Kato

    GASTROINTESTINAL ENDOSCOPY   73 ( 3 )   543 - 549   2011.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.gie.2010.11.015

    PubMed

    Web of Science

    researchmap

  • A case of severe acute pancreatitis and ischemic gastropathy caused by acute aortic dissection

    UMEDA Ikumi, HAYASHI Tsuyoshi, ISHIWATARI Hirotoshi, YOSHIDA Makoto, MIYANISHI Kouji, SATO Yasushi, KOFUNE Masayoshi, TAKIMOTO Risyu, KATO Junji, MEGURO Makoto, HIRATA Kouichi

    Nippon Shokakibyo Gakkai Zasshi   108 ( 1 )   103 - 110   2011.1

    　More details

    Language：Japanese   Publisher：The Japanese Society of Gastroenterology  

    A 49-year-old man presented with chest pain and was given a diagnosis of aortic dissection based on computed tomography (CT) findings. Two days later the dissection reached the origin of the celiac artery and there was poor blood flow from the body to the tail of the pancreas and fundus of the stomach wall. Severe acute pancreatitis developed. Endoscopy showed a near-circumferential gastric ulcer in the gastric cardia and we diagnosed ischemic gastropathy. A fistula between the area of infected pancreatic necrosis and the stomach had formed spontaneously and the necrotic tissue was draining into the stomach. His recovery was uneventful.<br>

    DOI： 10.11405/nisshoshi.108.103

    researchmap

  • Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer Reviewed

    Yasushi Sato, Tetsuji Takayama, Tamotsu Sagawa, Yasuo Takahashi, Hiroyuki Ohnuma, Syunichi Okubo, Naoaki Shintani, Shingo Tanaka, Masaya Kida, Yasuhiro Sato, Hidetoshi Ohta, Koji Miyanishi, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Koji Yamaguchi, Koichi Hirata, Yoshiro Niitsu, Junji Kato

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   66 ( 4 )   721 - 728   2010.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00280-009-1215-2

    PubMed

    Web of Science

    researchmap

  • ENDOSCOPIC FINDINGS OF ENTEROPATHY-TYPE T-CELL LYMPHOMA BY DOUBLE-BALLOON ENTEROSCOPY AND CAPSULE ENDOSCOPY Reviewed

    Yasushi Sato, Michihiro Ono, Tamotsu Sagawa, Rishu Takimoto, Masahiro Hirakawa, Hiroyuki Ohnuma, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    DIGESTIVE ENDOSCOPY   22 ( 3 )   243 - 245   2010.7

    　More details

  • 1. Apoptosis and Iron.

    Sato Tsutomu, Kobune Masayoshi, Kato Junji

    Nihon Naika Gakkai Kaishi   99 ( 6 )   1272 - 1276   2010.6

    　More details

    Language：Japanese   Publisher：The Japanese Society of Internal Medicine  

    Other Link： https://jlc.jst.go.jp/DN/JALC/00352924733?from=CiNii

    DOI： 10.2169/naika.99.1272

    researchmap

  • 非アルコール性脂肪性肝炎における鉄吸収亢進機序と除鉄療法の有用性の検討 Reviewed

    宮西 浩嗣, 河野 豊, 小船 雅義, 高田 弘一, 永島 裕之, 佐藤 康史, 瀧本 理修, 加藤 淳二

    アルコールと医学生物学   29   142 - 146   2010.4

    　More details

    Language：Japanese   Publisher：(株)響文社  

    Ichushi

    researchmap

  • 胆管過誤腫様変化と胆管細胞腺腫が併存した肝内胆管癌の1例 Reviewed

    高橋 祥, 高田 弘一, 河野 豊, 宮西 浩嗣, 石渡 裕俊, 林 毅, 佐川 保, 佐藤 勉, 佐藤 康史, 瀧本 理修, 小船 雅義, 黒岩 巌志, 平山 眞章, 飛岡 弘敏, 平田 公一, 尾松 睦子, 長谷川 匡, 加藤 淳二

    日本消化器病学会雑誌   107 ( 3 )   461 - 469   2010.3

    　More details

    Language：Japanese   Publisher：(一財)日本消化器病学会  

    Ichushi

    researchmap

  • Pure Red Cell Aplasia Associated with Good&apos;s Syndrome Accompanied by Decreased Stem Cell Factor Production in the Bone Marrow Reviewed

    Kageaki Kuribayashi, Akihito Fujimi, Masayoshi Kobune, Rishu Takimoto, Shohei Kikuchi, Satoshi Iyama, Junji Kato, Yoshiro Niitsu, Naoki Watanabe

    INTERNAL MEDICINE   49 ( 5 )   377 - 382   2010

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2169/internalmedicine.49.2811

    Web of Science

    researchmap

  • Therapeutic results in patients with biphenotypic acute leukemia at Sapporo Medical University Hospital Reviewed

    Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   37 ( 10 )   2011 - 2013   2010

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Journal of Cancer and Chemotherapy Publishers Inc.  

    PubMed

    researchmap

  • Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms Reviewed

    Tsuyoshi Hayashi, Hirotoshi Ishiwatari, Hideyuki Ihara, Yutaka Kawano, Koichi Takada, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Tomoko Sonoda, Tetsuji Takayama, Junji Kato, Yoshiro Niitsu

    JOURNAL OF GASTROENTEROLOGY   44 ( 9 )   964 - 975   2009.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00535-009-0089-8

    Web of Science

    researchmap

  • ヘッジホッグ・シグナル伝達阻害剤は、CD34+白血病細胞の薬剤耐性を解除する Reviewed

    菊地 尚平, 小船 雅義, 村瀬 和幸, 井山 諭, 佐藤 勉, 瀧本 理修, 河野 豊, 宮西 浩嗣, 佐藤 康史, 加藤 淳二

    臨床血液   50 ( 9 )   1113 - 1113   2009.9

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    Ichushi

    researchmap

  • Drug resistance is dramatically restored by hedgehog inhibitors in CD34(+) leukemic cells Reviewed

    Masayoshi Kobune, Rishu Takimoto, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Shohei Kikuchi, Yutaka Kawano, Kohji Miyanishi, Yasushi Sato, Yoshiro Niitsu, Junji Kato

    CANCER SCIENCE   100 ( 5 )   948 - 955   2009.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1349-7006.2009.01111.x

    PubMed

    Web of Science

    researchmap

  • Chronic idiopathic neutropenia associated with granular lymphocytic leukemia effectively treated with immunosuppressants

    Yuko Fujimi, Yasuo Hirayama, Hiroyuki Kuroda, Toshiro Sakai, Yuichi Konuma, Kyuhei Kohda, Akihito Fujimi, Satoshi Iyama, Tsutomu Sato, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    Biotherapy   23 ( 3 )   263 - 266   2009.5

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    researchmap

  • De novo follicular regeneration of the skin by wingless int 3 and bone morphogenetic protein 2 genes introduced into dermal fibroblasts and fibroblast growth factor-2 protein Reviewed

    Ichiro Ono, Yoshikiyo Akasaka, Takafumi Kamiya, Makito Sato, Masayoshi Kobune, Hirofumi Hamada, Toshiharu Yamashita

    WOUND REPAIR AND REGENERATION   17 ( 3 )   436 - 446   2009.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1524-475X.2009.00491.x

    Web of Science

    researchmap

  • Late Onset Neutropenia and Immunoglobulin Suppression of the Patients with Malignant Lymphoma Following Autologous Stem Cell Transplantation with Rituximab Reviewed

    Yasuo Hirayama, Kyuhei Kohda, Yuichi Konuma, Yasuji Hirata, Hiroyuki Kuroda, Yuko Fujimi, Sayaka Shirao, Masayoshi Kobune, Rishu Takimoto, Takuya Matsunaga, Junji Kato

    INTERNAL MEDICINE   48 ( 1 )   57 - 60   2009

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2169/internalmedicine.48.1368

    Web of Science

    researchmap

  • A case of solitary fibrous tumor of the pancreas Reviewed

    Hirotoshi Ishiwatari, Tsuyoshi Hayashi, Makoto Yoshida, Ganji Kuroiwa, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Yasutoshi Kimura, Tadashi Hasegawa, Koichi Hirata, Junji Kato

    Journal of Japanese Society of Gastroenterology   106 ( 7 )   1078 - 1085   2009

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    PubMed

    researchmap

  • 金属代謝異常(鉄・亜鉛と肝障害) 鉄とC型肝炎 Reviewed

    宮西 浩嗣, 河野 豊, 小船 雅義, 加藤 淳二

    日本病態栄養学会誌   11 ( 5 )   76 - 76   2008.12

    　More details

    Language：Japanese   Publisher：(一社)日本病態栄養学会  

    Ichushi

    researchmap

  • 腫瘍内出血によりDICが惹起された悪性黒色腫多発肝転移にDSM併用CDDP動注化学療法が有効であった1例 Reviewed

    高田 弘一, 加藤 淳二, 河野 豊, 高橋 祥, 林 毅, 石渡 裕俊, 宮西 浩嗣, 瀧本 理修, 小船 雅義, 佐川 保, 佐藤 勉, 佐藤 康史, 山下 利春, 名取 博, 新津 洋司郎

    癌と化学療法   35 ( 10 )   1803 - 1805   2008.10

    　More details

    Language：Japanese   Publisher：(株)癌と化学療法社  

    Ichushi

    researchmap

  • [Effective CDDP arterial infusion with DSM for liver metastasis of malignant melanoma complicating DIC due to intratumoral hemorrhage--a case report]. Reviewed

    Kohichi Takada, Junji Kato, Yutaka Kawano, Sho Takahashi, Tsuyoshi Hayashi, Hirotoshi Ishiwatari, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Tamotsu Sagawa, Tsutomu Sato, Yasushi Sato, Toshiharu Yamashita, Hiroshi Natori, Yoshiro Niitsu

    Gan to kagaku ryoho. Cancer & chemotherapy   35 ( 10 )   1803 - 5   2008.10

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    A 65-year-old male, who had been diagnosed with melanoma of stage IIB and treated by chemotherapy since 2003 at the Dermatology Department, was referred to our department for liver metastasis of melanoma that had become resistant to chemotherapeutic agents. In 2006, he started receiving hepatic arterial infusion of CDDP. He was admitted to the hospital on an emergency basis for general fatigue the next May. Blood tests revealed anemia and thrombocytopenia. Contrast CT showed aggravation of liver metastasis. Contrast ultrasonography revealed nodular contrast enhancement at the margin of the tumor. On the basis of image findings and blood test results, DIC due to intratumoral hemorrhage was diagnosed. CDDP arterial infusion with DSM resulted in improved DIC, and he was able to be discharged. Taken together, attention has to be paid to the potential for emergency complications of DIC due to liver metastasis of melanoma with intratumoral hemorrhage. Moreover, it was shown that arterial infusion with DSM was effective for liver metastasis of melanoma.

    PubMed

    researchmap

  • Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice. Reviewed

    Sagawa T, Yamada Y, Takahashi M, Sato Y, Kobune M, Takimoto R, Fukaura J, Iyama S, Sato T, Miyanishi K, Matsunaga T, Takayama T, Kato J, Sasaki K, Hamada H, Niitsu Y

    Hepatology (Baltimore, Md.)   48 ( 3 )   828 - 840   2008.9

    　More details

  • Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells Reviewed

    Masayoshi Kobune, Yutaka Kawano, Sho Takahashi, Kohichi Takada, Kazuyuki Murase, Satosi Iyama, Tsutomu Sato, Rishu Takimoto, Yoshiro Niitsu, Junji Kato

    EXPERIMENTAL HEMATOLOGY   36 ( 9 )   1121 - 1131   2008.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.exphem.2008.04.007

    PubMed

    Web of Science

    researchmap

  • Apoptosis supercedes necrosis in mitochondrial DNA-depleted Jurkat cells by cleavage of receptor-interacting protein and inhibition of lysosomal cathepsin Reviewed

    Tsutomu Sato, Takuro Machida, Sho Takahashi, Kazuyuki Murase, Yutaka Kawano, Tsuyoshi Hayashi, Satoshi Iyama, Kohich Takada, Kageaki Kuribayashi, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Takuya Matsunaga, Junji Kato, Yoshiro Niitsu

    JOURNAL OF IMMUNOLOGY   181 ( 1 )   197 - 207   2008.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Web of Science

    researchmap

  • Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages. Reviewed

    A. Fujimi, T. Matsunaga, M. Kobune, Y. Kawano, T. Nagaya, I. Tanaka, S. Iyama, T. Hayashi, T. Sato, K. Miyanishi, T. Sagawa, Y. Sato, R. Takimoto, T. Takayama, J. Kato, S. Gasa, H. Sakai, E. Tsuchida, K. Ikebuchi, H. Hamada, Y. Niitsu

    Int. J. Hematol.   87   339-350   2008.5

    　More details

    Language：English  

    DOI： 10.1007/s12185-008-0062-y

    researchmap

  • Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone Reviewed

    Yasushi Sato, Kazuyuki Murase, Junji Kato, Masayoshi Kobune, Tsutomu Sato, Yutaka Kawano, Rishu Takimoto, Kouichi Takada, Koji Miyanishi, Takuya Matsunaga, Tetsuji Takayama, Yoshiro Niitsu

    NATURE BIOTECHNOLOGY   26 ( 4 )   431 - 442   2008.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/nbt1396

    PubMed

    Web of Science

    researchmap

  • Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo Reviewed

    Masayoshi Kobune, Junii Kato, Yutaka Kawano, Katsunori Sasaki, Hiroaki Uchida, Kohichi Takada, Sho Takahashi, Rishu Takimoto, Yoshiro Niitsu

    STEM CELLS   26 ( 2 )   534 - 542   2008.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1634/stemcells.2007-0741

    Web of Science

    researchmap

  • Successful treatment of autoimmune pancreatitis complicated with autoimmune thrombocytopenia and interstitial pneumonia by prednisolone Reviewed

    Kazuyuki Murase, Takuya Matsunaga, Tsuyoshi Hayashi, Hirotoshi Ishiwatari, Naoko Araki, Satoshi Iyama, Tsutomu Sato, Masayoshi Kobune, Rishu Takimoto, Koji Miyanishi, Toru Miyazaki, Hisami Ikeda, Junji Kato, Yoshiro Niitsu

    INTERNAL MEDICINE   47 ( 11 )   1033 - 1038   2008

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2169/internalmedicine.47.0803

    PubMed

    Web of Science

    researchmap

  • Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate Reviewed

    Satoshi Iyama, Takuya Matsunaga, Tsutomu Sato, Kazuyuki Murase, Naoko Araki, Rishu Takimoto, Masayoshi Kobune, Tamotsu Sagawa, Tetsuji Takayama, Yoshiro Niitsu

    INTERNAL MEDICINE   47 ( 8 )   791 - 794   2008

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2169/internalmedicine.47.0714

    PubMed

    Web of Science

    researchmap

  • Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C Reviewed

    Junji Kato, Koji Miyanishi, Masayoshi Kobune, Tokiko Nakamura, Kohichi Takada, Rishu Takimoto, Yutaka Kawano, Sho Takahashi, Minoru Takahashi, Yasushi Sato, Tetsuji Takayama, Yoshiro Niitsu

    JOURNAL OF GASTROENTEROLOGY   42 ( 10 )   830 - 836   2007.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00535-007-2095-z

    PubMed

    Web of Science

    researchmap

  • 非アルコール性脂肪性肝炎における鉄代謝異常の分子機構解析 Reviewed

    高田 弘一, 加藤 淳二, 河野 豊, 高橋 祥, 小船 雅義, 瀧本 理修, 宮西 浩嗣, 新津 洋司郎

    アルコールと医学生物学   27   160 - 163   2007.9

    　More details

    Language：Japanese   Publisher：(株)響文社  

    Ichushi

    researchmap

  • [Superior mesenteric and portal vein thrombosis in a polycythemia vera patient with JAK2 mutation]. Reviewed

    Naoko Araki, Rishu Takimoto, Hiroki Chiba, Hironobu Araki, Tsutomu Sato, Satoshi Iyama, Masahiro Hirakawa, Kaoru Ono, Yutaka Kawano, Koichi Takada, Koji Miyanishi, Masayoshi Kobune, Takuya Matsunaga, Junji Kato, Tokiko Nakamura, Yoshiro Niitsu

    [Rinsho ketsueki] The Japanese journal of clinical hematology   48 ( 7 )   554 - 8   2007.7

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    A 47-year-old woman was admitted to our hospital in December 1994 with polycythemia. The patient's red blood cell volume was 33 ml/kg and bone marrow cytology was able to rule out other myeloproliferative diseases such as chronic myelogenous leukemia, essential thrombocytosis and myelofibrosis. The patient was diagnosed as having polycythemia vera. She had undergone only phlebotomy until 1999 when the thrombocytosis appeared, subsequent to which she was treated with oral hydroxyurea. However, in March 2006, she developed upper abdominal pain and was admitted to our hospital on March 14th, 2006. Computed tomography scan revealed thromboses in the portal and superior mesenteric veins. Anticoagulation therapy delivered intravenously via the superior mesenteric vein dramatically improved her symptoms and liver function. She is currently on anticoagulation therapy in our outpatient clinic.

    PubMed

    researchmap

  • Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism. Reviewed

    Kobune M, Chiba H, Kato J, Kato K, Nakamura K, Kawano Y, Takada K, Takimoto R, Takayama T, Hamada H, Niitsu Y

    Molecular cancer therapeutics   6 ( 6 )   1774 - 1784   2007.6

    　More details

  • Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation. Reviewed

    Kato J, Kobune M, Ohkubo S, Fujikawa K, Tanaka M, Takimoto R, Takada K, Takahari D, Kawano Y, Kohgo Y, Niitsu Y

    Experimental hematology   35 ( 6 )   879 - 887   2007.6

    　More details

  • C型慢性肝炎および非アルコール性脂肪性肝炎における鉄吸収関連分子の解析 Reviewed

    高田 弘一, 加藤 淳二, 河野 豊, 高橋 祥, 小船 雅義, 瀧本 理修, 宮西 浩嗣, 新津 洋司郎

    肝臓   48 ( Suppl.1 )   A31 - A31   2007.4

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • [Factor XI deficiency caused by a mutation of Gly400Val]. Reviewed

    Sato T, Iyama S, Araki N, Murase K, Sato Y, Kobune M, Takimoto R, Matsunaga T, Kato J, Kuroda H, Niitsu Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   48 ( 2 )   148 - 150   2007.2

    　More details

  • Ex vivo large-scale generation of human platelets from cord blood CD34+ cells. Reviewed

    Matsunaga T, Tanaka I, Kobune M, Kawano Y, Tanaka M, Kuribayashi K, Iyama S, Sato T, Sato Y, Takimoto R, Takayama T, Kato J, Ninomiya T, Hamada H, Niitsu Y

    Stem cells (Dayton, Ohio)   24 ( 12 )   2877 - 2887   2006.12

    　More details

  • Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappa B Reviewed

    Y. Sato, J. Kato, R. Takimoto, K. Takada, Y. Kawano, K. Miyanishi, M. Kobune, Y. Sato, T. Takayama, T. Matunaga, Y. Niitsu

    GUT   55 ( 12 )   1801 - 1808   2006.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1136/gut.2005.070417

    Web of Science

    researchmap

  • 慢性炎症と貧血

    小船 雅義, 加藤 淳二

    日本内科学会雑誌   95 ( 10 )   2016 - 2020   2006.10

    　More details

    Language：Japanese   Publisher：The Japanese Society of Internal Medicine  

    慢性炎症性疾患では, 血清鉄低値を示すのにもかかわらず, 血清フェリチン値が正常から増加するという鉄代謝異常を伴った正球性から小球性の貧血 (anemia of chronic disorders, ACD) が発症する. この鉄代謝異常の分子機構の詳細は長年の間不明であったが, 最近, 炎症性サイトカインにより肝でヘプシジンというペプチドホルモンの産生が誘導されることが見出され, これこそがACDの病態の主要なエフェクターであることが明らかとなった. 本稿では最近解明されたACD発症の分子機構と治療法について解説する.

    Other Link： https://jlc.jst.go.jp/DN/JALC/00285792140?from=CiNii

    DOI： 10.2169/naika.95.2016

    researchmap

  • アルコール性および非アルコール性脂肪性肝炎における鉄代謝異常の解析および酸化的DNA障害の検討 Reviewed

    高田 弘一, 加藤 淳二, 河野 豊, 高橋 祥, 奥田 敏徳, 小船 雅義, 瀧本 理修, 宮西 浩嗣, 新津 洋司郎

    アルコールと医学生物学   26   91 - 95   2006.9

    　More details

    Language：Japanese   Publisher：(株)響文社  

    Ichushi

    researchmap

  • ウルソデオキシコール酸投与中に自己免疫性肝炎が増悪したPBC-AIH overlap症候群の1例 Reviewed

    高田 弘一, 加藤 淳二, 高梨 訓博, 河野 豊, 奥田 敏徳, 林 毅, 石渡 裕俊, 高橋 祥, 宮西 浩嗣, 佐藤 勉, 佐藤 康史, 瀧本 理修, 小船 雅義, 高山 哲治, 高橋 稔, 佐々木 文, 新津 洋司郎

    肝臓   47 ( 6 )   304 - 309   2006.6

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • 酸化ストレスと肝疾患 C型慢性肝炎おける鉄代謝異常の発生機序の検討 Reviewed

    宮西 浩嗣, 加藤 淳二, 河野 豊, 小船 雅義, 高田 弘一, 藤川 幸司, 奥田 敏徳, 石渡 裕俊, 林 毅, 佐藤 康史, 新津 洋司郎

    肝臓   47 ( Suppl.1 )   A45 - A45   2006.4

    　More details

    Language：Japanese   Publisher：(一社)日本肝臓学会  

    Ichushi

    researchmap

  • 臍帯血由来の血小板輸血製剤の可能性 不死化ヒト骨髄ストローマ細胞(hTERT stroma)を用いた効率的な血小板培養法 Reviewed

    松永 卓也, 田中 育太, 小船 雅義, 河野 豊, 田中 真樹, 栗林 景晶, 濱田 洋文, 新津 洋司郎

    日本内科学会雑誌   95 ( Suppl. )   158 - 158   2006.2

    　More details

    Language：Japanese   Publisher：(一社)日本内科学会  

    Ichushi

    researchmap

  • 不死化ヒト・ストローマ及び間葉系幹細胞におけるWnt遺伝子の発現とその造血支持能に対する効果 Reviewed

    千葉 大樹, 小船 雅義, 河野 豊, 伊藤 克礼, 中村 公則, 出張 裕也, 内田 宏昭, 松永 卓也, 加藤 淳二, 濱田 洋文, 新津 洋司郎

    臨床血液   44 ( 8 )   732 - 732   2003.8

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    Ichushi

    researchmap

  • Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans cinnamon rats Reviewed

    J Kato, M Kobune, Y Kohgo, N Sugawara, H Hisai, T Nakamura, S Sakamaki, N Sawada, Y Niitsu

    JOURNAL OF CLINICAL INVESTIGATION   98 ( 4 )   923 - 929   1996.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Web of Science

    researchmap

  • A type II b early gastric cancer associated with diffuse submucosal ectopic glands, report of a case Reviewed

    Yasushi Tsuji, Yasuo Takahashi, Masayoshi Kobune, Hirohito Muramatsu, Seishi Ishigaki, Naoki Watanabe, Yoshiro Niitsu

    Japanese Journal of Gastroenterology   91 ( 12 )   2214 - 2218   1994

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.11405/nisshoshi1964.91.2214

    PubMed

    researchmap

  • ECTOPIC CHOROIDAL CALCIFICATION OF THE EYES OF A PATIENT WITH PARATHYROID ADENOMA Reviewed

    M KOBUNE, H NEDA, Y MOGI, Y HIRAYAMA, S SAKAMAKI, N WATANABE, Y KOHGO, Y NIITSU

    INTERNAL MEDICINE   32 ( 1 )   57 - 59   1993.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Web of Science

    researchmap

▼display all

MISC

  • 低用量IL2はBCL2の発現を誘導することでCD4制御性T細胞のアポトーシスを抑制する(Low-close interleukin-2 induces BCL2 expression and resistance to apoptosis in CD4 regulatory T Cells)

    松野 鉄平, 村瀬 和幸, 高田 弘一, 河野 豊, 平川 昌宏, 宮西 浩嗣, 小船 雅義, 加藤 淳二

    札幌医学雑誌   87 ( 1-6 )   49 - 61   2018.12

    　More details

    Language：English   Publisher：札幌医科大学  

    Ichushi

    researchmap

  • Abnormal intracellular response induced by iron overload

    73 ( 4 )   503 - 508   2016.10

    　More details

  • Multiple hepatocellular adenomas: A case report

    Fumito Tamura, Yutaka Kawano, Koji Miyanishi, Tomohiro Kubo, Yusuke Kamihara, Yutaka Okagawa, Kazuma Ishikawa, Kohichi Takada, Tsuyoshi Hayashi, Tsutomu Sato, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Masaki Kawamoto, Makoto Meguro, Toru Mizuguchi, Ziro Ogino, Tadashi Hasegawa, Norihide Yoneda, Motoko Sasaki, Junji Kato

    Acta Hepatologica Japonica   56   584 - 595   2015.12

    　More details

  • 進行食道癌に対するdocetaxel、nedaplatin、5-FU、放射線同時併用療法(DNF-R)の第I/II相試験

    大沼 啓之, 佐藤 康史, 大須賀 崇裕, 林 毅, 佐藤 勉, 宮西 浩嗣, 小船 雅義, 瀧本 理修, 加藤 淳二, 佐川 保, 堀 正和, 染谷 正則, 中田 健生, 坂田 耕一

    北海道医学雑誌   90 ( 2 )   152 - 153   2015.11

    　More details

    Language：Japanese   Publisher：北海道医学会  

    Ichushi

    researchmap

  • Erythroferrone as a new erythroid regulator of iron metabolism

    70 ( 3 )   302 - 307   2015.3

    　More details

  • Molecular mechanism of regulation in iron-metabolism

    56 ( 10 )   1033 - 1037   2012.10

    　More details

  • Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells.

    Hamada Shin, Masamune Atsushi, Takikawa Tetsuya, Suzuki Noriaki, Kikuta Kazuhiro, Hirota Morihisa, Hamada Hirofumi, Kobune Masayoshi, Satoh Kennichi, Shimosegawa Tooru

    Biochem Biophys Res Commun   421 ( 2 )   349 - 354   2012

    　More details

  • Evaluation of the Efficacy of Liposomal Amphotericin B

    IYAMA Satoshi, MURASE Kazuyuki, SATO Tsutomu, KIKUCHI Shohei, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Risyu, KATO Junji

    Kansenshogaku Zasshi   84 ( 2 )   182 - 186   2010.3

    　More details

    Language：Japanese   Publisher：The Japanese Association for Infectious Diseases  

    A retrospective study was performed to evaluate the efficacy and safety of liposomal amphotericin B (L-AMB) in a total of 32 cases who were among patients hospitalized at the Fourth Department of Internal Medicine, Sapooro Medical University from December 2006 to April 2008. Primary diagnoses were hematologic diseases in 87.5％of subjects. The most common hematologic diseases included acute myelogenous leukemia in 50％of the subjects, followed by malignant lymphoma in 12.5％of the subjects. The mean administration period was 14.2±12.9 days, and the mean cumulative dose was 1,786±2,181 mg. L-AMB improved 21 of 29 cases (72.4％) with some fungal infections or fever-associated neutropenia. Adverse events occurred in 9 cases to a slight degree, in 7 cases to a moderate degree, and in no case to a severe degree. Hypokalemia and hypercreatininemia were seen in 7 cases (21.9％) and 4 cases (12.5％), respectively, but these adverse reactions were so mild that the treatment did not need to be discontinued. Any adverse reactions for which treatment administration was discontinued were confirmed to have disappeared at the end of the study. These results support the efficacy and safety of L-AMB in accordance with previous foreign reports. It was noteworthy that early use of L-AMB prior to established diagnosis sometimes better therapeutic outcomes. It was also suggested that L-AMB could be safely administered while controlling electrolyte balance, such as serum potassium concentration, with sufficient fluid replacement, including physiological saline infusion. There are limitations in the use of the conventional form of amphotericin B because of its renal toxicity and other reasons. However, L-AMB had fewer side effects, so the agent was considered useful for the treatment of hematologic disease patients who either had mycosis or carried a risk for fungal infection.

    DOI： 10.11150/kansenshogakuzasshi.84.182

    researchmap

  • Ferritin

    Japanese journal of clinical medicine   67   266 - 269   2009.12

    　More details

  • Acute mesenteric ischemia associated with thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus

    104 ( 3 )   575 - 578   2009.9

    　More details

  • Anemia in patient with cancer

    58 ( 8 )   1769 - 1773   2009.8

    　More details

  • 慢性炎症と貧血 (特集 貧血--日常診療に即したとらえ方)

    小船 雅義, 加藤 淳二

    成人病と生活習慣病   39 ( 7 )   766 - 770   2009.7

    　More details

    Language：Japanese   Publisher：東京医学社  

    Other Link:： http://search.jamas.or.jp/link/ui/2009287722

    researchmap

  • Role of oxidative stress in hepatocarcinogenesis

    Japanese journal of clinical medicine   67   101 - 104   2009.5

    　More details

  • 鉄代謝異常と疾患

    小船 雅義, 加藤 淳二

    日本医事新報   ( 4400 )   60 - 64   2008.8

    　More details

    Language：Japanese   Publisher：日本医事新報社  

    Other Link:： http://search.jamas.or.jp/link/ui/2008318933

    researchmap

  • Anemia in patient with cancer

    Japanese journal of clinical medicine   66 ( 3 )   524 - 529   2008.3

    　More details

  • Rituximab併用CHOP療法におけるLamivudine予防投与終了後にHBV再活性化を認めたDiffuse Large B-cell Lymphoma

    小野 薫, 井山 諭, 松永 卓也, 佐藤 勉, 佐藤 康史, 奥田 敏徳, 高田 弘一, 河野 豊, 林 毅, 宮西 浩嗣, 佐川 保, 小船 雅義, 瀧本 理修, 加藤 淳二, 新津 洋司郎

    癌と化学療法   34 ( 9 )   1509 - 1512   2007.9

    　More details

    Language：Japanese   Publisher：(株)癌と化学療法社  

    Ichushi

    researchmap

  • 骨髄腫から産生されるWnt3はRhoA/ROCKシグナルを活性化し、インテグリンα6β1依存性のCAM-DRを惹起する

    小船 雅義, 河野 豊, 井山 諭, 佐藤 勉, 瀧本 理修, 松永 卓也, 加藤 淳二, 濱田 洋文, 新津 洋司郎

    臨床血液   48 ( 9 )   870 - 870   2007.9

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    Ichushi

    researchmap

  • 上腸間膜静脈・門脈血栓症を発症したJAK2変異を伴った真性多血症

    荒木 直子, 瀧本 理修, 千葉 大樹, 荒木 啓伸, 佐藤 勉, 井山 諭, 平川 昌宏, 小野 薫, 河野 豊, 高田 弘一, 宮西 浩嗣, 小船 雅義, 松永 卓也, 加藤 淳二, 中村 とき子, 新津 洋司郎

    臨床血液   48 ( 7 )   554 - 558   2007.7

    　More details

    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    Ichushi

    researchmap

  • 消化器疾患モデル動物 肝炎モデル動物 自然肝炎発症モデルとその応用

    小船 雅義, 加藤 淳二, 河野 豊, 新津 洋司郎

    分子消化器病   3 ( 2 )   172 - 176   2006.6

    　More details

    Language：Japanese   Publisher：(株)先端医学社  

    Ichushi

    researchmap

  • Ex vivo expansion of G-CSF-mobilized peripheral blood CD133(+) progenitor cells on coculture with human stromal cells

    Y Kawano, M Kobune, H Chiba, K Nakamura, R Takimoto, K Takada, Y Ito, J Kato, H Hamada, Y Niitsu

    EXPERIMENTAL HEMATOLOGY   34 ( 2 )   150 - 158   2006.2

    　More details

  • Konnichi no tiryousisin

    Igaku syoin   2006

    　More details

  • 臨床各論．3 赤血球の疾患 A．貧血 a 鉄欠乏性貧血

    三輪血液病学   2006

    　More details

  • 今日の治療指針

    医学書院   2006

    　More details

  • 3 Disorder of Red Blood Cells, A. Anemia, a Iron-deficiency anemia

    Miwa hematology   2006

    　More details

  • Telomerized human bone marrow-derived cell clones maintain the phenotype of hematopoietic-supporting osteoblastic and myofibroblastic stromal cells after long-term culture

    M Kobune, J Kato, H Chiba, Y Kawano, M Tanaka, R Takimoto, H Hamada, Y Niitsu

    EXPERIMENTAL HEMATOLOGY   33 ( 12 )   1544 - 1553   2005.12

    　More details

  • 【鉄代謝制御タンパク質研究の進歩】肝臓での鉄蓄積機序とその制御

    河野 豊, 小船 雅義, 加藤 淳二

    細胞   37 ( 10 )   399 - 403   2005.9

    　More details

    Language：Japanese   Publisher：(株)ニュー・サイエンス社  

    Ichushi

    researchmap

  • Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion

    Y Sato, H Araki, J Kato, K Nakamura, Y Kawano, M Kobune, T Sato, K Miyanishi, T Takayama, M Takahashi, R Takimoto, S Iyama, T Matsunaga, S Ohtani, A Matsuura, H Hamada, Y Niitsu

    BLOOD   106 ( 2 )   756 - 763   2005.7

    　More details

  • Augmentation of antitumor effects of p53 gene therapy by combination with HDAC inhibitor

    R Takimoto, J Kato, T Terui, K Takada, G Kuroiwa, J Wu, H Ohnuma, D Takahari, M Kobune, Y Sato, T Takayama, T Matsunaga, Y Niitsu

    CANCER BIOLOGY & THERAPY   4 ( 4 )   421 - 428   2005.4

    　More details

    Language：English  

    Web of Science

    researchmap

  • Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy. International journal

    Hirofumi Hamada, Masayoshi Kobune, Kiminori Nakamura, Yutaka Kawano, Kazunori Kato, Osamu Honmou, Kiyohiro Houkin, Takuya Matsunaga, Yoshiro Niitsu

    Cancer science   96 ( 3 )   149 - 56   2005.3

    　More details

    Language：English  

    We developed human mesenchymal stem cell (MSC) lines that could differentiate into various tissue cells including bone, neural cells, bone marrow (BM) stromal cells supporting the growth of hematopoietic stem cell (HSC), and so-called 'tumor stromal cells' mixing with tumor cells. We investigated the applicability of MSC as therapeutic cell transplanting reagents (cytoreagents). Telomerized human BM derived stromal cells exhibited a prolonged lifespan and supported the growth of hematopoietic clonogenic cells. The gene transfer of Indian hedgehog (Ihh) remarkably enhanced the HSC expansion supported by the human BM stromal cells. Gene-modified MSC are useful as therapeutic tools for brain tissue damage (e.g. brain infarction) and malignant brain neoplasms. MSC transplantation protected the brain tissue from acute ischemic damage in the midcerebral artery occlusion (MCAO) animal model. Brain-derived neurotrophic factor (BDNF)-gene transduction further enhanced the protective efficacy against the ischemic damage. MSC possessed excellent migratory ability and exerted inhibitory effects on the proliferation of glioma cells. Gene-modification of MSC with therapeutic cytokines clearly augmented the antitumor effect and prolonged the survival of tumor-bearing animals. Gene therapy employing MSC as a tissue-protecting and targeting cytoreagent would be a promising approach.

    DOI： 10.1111/j.1349-7006.2005.00032.x

    PubMed

    researchmap

  • Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model

    K Kurozumi, K Nakamura, T Tamiya, Y Kawano, K Ishii, M Kobune, S Hirai, H Uchida, K Sasaki, Y Ito, K Kato, O Honmou, K Houkin, Date, I, H Hamada

    MOLECULAR THERAPY   11 ( 1 )   96 - 104   2005.1

    　More details

  • Expansion of CD34(+) cells on telomerized human stromal cells without losing erythroid-differentiation potential in a serum-free condition

    M Kobune, Y Kawano, J Kato, Y Ito, H Chiba, K Nakamura, A Fujimi, T Matsunaga, H Hamada, Y Niitsu

    INTERNATIONAL JOURNAL OF HEMATOLOGY   81 ( 1 )   18 - 25   2005.1

    　More details

  • C型慢性肝炎に対する瀉血療法

    今月の治療   2005

    　More details

  • Two cases of primary skeletal muscle lymphoma, and a review of the literature

    Rinsho Ketsueki   46 ( 10 )   1141 - 1145   2005

    　More details

  • 鉄過剰症候群の分子病態と新規鉄キレート剤

    小船雅義

    分子細胞治療   4   59 - 65   2005

    　More details

  • Q&A 鉄制限食の効果は？特集「脂肪性肝炎とC型肝炎」

    肥満と糖尿病   10   47 - 51   2005

    　More details

  • Incomplete entero-Behcet’s disease associated with essential thrombocythemia during hydroxyurea treatment

    Rinsho Ketsueki   46   1136 - 1140   2005

    　More details

  • Iron overload syndrom and new iron chelating drug

    Cellular Molecular Medicine   4   59 - 65   2005

    　More details

  • NASH and Hepatitis C

    Obesity and Diabetes mellitus   10   47 - 51   2005

    　More details

  • Molecular mechanism and management of hepatic iron overload syndrom

    Cell   2005

    　More details

  • Phlebotomy for management of hepatitis C

    Kongetsu no Chiryou   2005

    　More details

  • Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells

    H Chiba, M Kobune, J Kato, Y Kawano, Y Ito, K Nakamura, S Asakura, H Hamada, Y Niitsu

    EXPERIMENTAL HEMATOLOGY   32 ( 12 )   1194 - 1203   2004.12

    　More details

  • Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID-beta(2)m(-/-) repopulating cells

    M Kobune, Y Ito, Y Kawano, K Sasaki, H Uchida, K Nakamura, H Dehari, H Chiba, R Takimoto, T Matsunaga, T Terui, J Kato, Y Niitsu, H Hamada

    BLOOD   104 ( 4 )   1002 - 1009   2004.8

    　More details

  • Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model

    K Nakamura, Y Ito, Y Kawano, K Kurozumi, M Kobune, H Tsuda, A Bizen, O Honmou, Y Niitsu, H Hamada

    GENE THERAPY   11 ( 14 )   1155 - 1164   2004.7

    　More details

  • Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo

    H Uchida, T Tanaka, K Sasaki, K Kato, H Dehari, Y Ito, M Kobune, M Miyagishi, K Taira, H Tahara, H Hamada

    MOLECULAR THERAPY   10 ( 1 )   162 - 171   2004.7

    　More details

  • BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model

    K Kurozumi, K Nakamura, T Tamiya, Y Kawano, M Kobune, S Hirai, H Uchida, K Sasaki, Y Ito, K Kato, O Honmou, K Houkin, Date, I, H Hamada

    MOLECULAR THERAPY   9 ( 2 )   189 - 197   2004.2

    　More details

  • Wnt-β-カテニン・シグナル伝達

    分子消化器病   2004

    　More details

  • ヒト間葉系幹細胞の不死化と再生医療への応用

    小船 雅義, 伊藤 克礼, 新津 洋司郎

    最新医学   54 ( 5 )   1108 - 1113   2004

    　More details

    Language：Japanese   Publisher：最新医学社  

    Other Link:： http://search.jamas.or.jp/link/ui/2004213747

    researchmap

  • Wnt beta-catenin signaling

    Molecular gastroenterology   2004

    　More details

  • [Successful treatment with antiviral agents for human herpesvirus type 6 encephalitis following reduced intensity stem cell transplantation in a patient with myelodysplastic syndrome]

    Hiroki CHIBA, Yasuo HIRAYAMA, Yasushi TSUJI, Sumio SAKAMAKI, Tamotsu SAGAWA, Ganji KUROIWA, Masayoshi KOBUNE, Takuya MATSUNAGA, Junji KATO, Yoshiro NIITSU

    Rinsho Ketsueki   45 ( 6 )   473 - 477   2004

    　More details

  • フェリチン

    日本臨床-広範囲 血液・尿化学検査・免疫学的検査 2004 Nov;62 Suppl 11:237-9.   62   237 - 9   2004

    　More details

  • 第４章、肝疾患における血液学

    シャーロックの肝臓病学   2004

    　More details

  • Chapter 4, Hematology in hepatic disorder

    Hepatology by Sherlock   2004

    　More details

  • Application of telomerized human mesenchymal stem cells for tissue engineering

    Saishin Igaku   54   1108 - 1113   2004

    　More details

  • [Ferritin]

    Nihonrinsho-kouhani Hematological-Urological-immunological examination 2004 Nov;62 Suppl 11:237-9.   62   237 - 9   2004

    　More details

  • Pre-administration of angiopoietin-1 followed by VEGF induces functional and mature vascular formation in a rabbit ischemic model

    A Yamauchi, Y Ito, M Morikawa, M Kobune, JH Huang, K Sasaki, K Takahashi, K Nakamura, H Dehari, Y Niitsu, T Abe, H Hamada

    JOURNAL OF GENE MEDICINE   5 ( 11 )   994 - 1004   2003.11

    　More details

  • Bcl-xL gene transfer protects the heart against ischemia/reperfusion injury

    JH Huang, Y Ito, M Morikawa, H Uchida, M Kobune, K Sasaki, T Abe, H Hamada

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   311 ( 1 )   64 - 70   2003.11

    　More details

  • Myocardial injection of CA promoter-based plasmid mediates efficient transgene expression in rat heart

    JH Huang, Y Ito, M Kobune, K Sasaki, K Nakamura, H Dehari, K Takahashi, K Ikeda, H Uchida, K Kato, H Hamada

    JOURNAL OF GENE MEDICINE   5 ( 10 )   900 - 908   2003.10

    　More details

  • Increased expression of angiogenin in hepatocellular carcinoma in correlation with tumor vascularity

    H Hisai, J Kato, M Kobune, T Murakami, K Miyanishi, M Takahashi, N Yoshizaki, R Takimoto, T Terui, Y Niitsu

    CLINICAL CANCER RESEARCH   9 ( 13 )   4852 - 4859   2003.10

    　More details

    Language：English  

    Web of Science

    researchmap

  • Adenoviral-delivered angiopoietin-1 reduces the infarction and attenuates the progression of cardiac dysfunction in the rat model of acute myocardial infarction

    K Takahashi, Y Ito, M Morikawa, M Kobune, JH Huang, M Tsukamoto, K Sasaki, K Nakamura, H Dehari, K Ikeda, H Uchida, S Hirai, T Abe, H Hamada

    MOLECULAR THERAPY   8 ( 4 )   584 - 592   2003.10

    　More details

  • Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia

    T Matsunaga, N Takemoto, T Sato, R Takimoto, Tanaka, I, A Fujimi, TH Akiyama, H Kuroda, Y Kawano, M Kobune, J Kato, Y Hirayama, S Sakamaki, K Kohda, K Miyake, Y Niitsu

    NATURE MEDICINE   9 ( 9 )   1158 - 1165   2003.9

    　More details

  • Telomerized human multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells

    M Kobune, Y Kawano, Y Ito, H Chiba, K Nakamura, H Tsuda, K Sasaki, H Dehari, H Uchida, O Honmou, S Takahashi, A Bizen, R Takimoto, T Matsunaga, J Kato, K Kato, K Houkin, Y Niitsu, H Hamada

    EXPERIMENTAL HEMATOLOGY   31 ( 8 )   715 - 722   2003.8

    　More details

  • Efficient BMP2 gene transfer and bone formation of mesenchymal stem cells by a fiber-mutant adenoviral vector

    H Tsuda, T Wada, Y Ito, H Uchida, H Dehari, K Nakamura, K Sasaki, M Kobune, T Yamashita, H Hamada

    MOLECULAR THERAPY   7 ( 3 )   354 - 365   2003.3

    　More details

  • Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells

    Y Kawano, M Kobune, M Yamaguchi, K Nakamura, Y Ito, K Sasaki, S Takahashi, T Nakamura, H Chiba, T Sato, T Matsunaga, H Azuma, K Ikebuchi, H Ikeda, J Kato, Y Niitsu, H Hamada

    BLOOD   101 ( 2 )   532 - 540   2003.1

    　More details

  • Enhanced antitumor effect of RGD fiber-modified adenovirus for gene therapy of oral cancer

    H Dehari, Y Ito, T Nakamura, M Kobune, K Sasaki, N Yonekura, G Kohama, H Hamada

    CANCER GENE THERAPY   10 ( 1 )   75 - 85   2003.1

    　More details

  • ヒトストローマ細胞を用いた造血幹細胞の増幅

    血液腫瘍科   47   479 - 2003   2003

    　More details

  • 8.血液・造血器疾患 Section I，4. 赤血球の基礎，C.フェロキネティクス．

    内科学   2003

    　More details

  • 鉄欠乏性貧血，溶血性貧血のマネージメント

    Medicina   2003

    　More details

  • Hematological disorder Section I, 4. Ferrokinetics

    Internal Medicine   2003

    　More details

  • A case of primary biliary cirrhosis with HLA-DR 8 complicated by polymyositis

    SATO Tsutomu, KATO Junji, SATO Yasushi, IYAMA Satoshi, TAKADA Kohichi, OKU Takatomi, TAKAHASHI Sho, MACHIDA Takurou, KOBUNE Masayoshi, MATSUNAGA Takuya, TAKAHASHI Minoru, NIITSU Yoshiro

    Kanzo   44 ( 9 )   455 - 459   2003

    　More details

    Language：Japanese   Publisher：The Japan Society of Hepatology  

    Other Link:： http://search.jamas.or.jp/link/ui/2004069904

    DOI： 10.2957/kanzo.44.455

    researchmap

  • Ethanol induces transforming growth factor-alpha expression in hepatocytes, leading to stimulation of collagen synthesis by hepatic stellate cells.

    Alcohol Clin Exp Res   27   58 - 63   2003

    　More details

  • A case of primary biliary chirosis and polymyositis associated with HLA-DR8

    Liver   2003

    　More details

  • Management of iron deficiency and hemolytic anemia

    Medicina   2003

    　More details

  • Ex vivo expansion of hematopoietic stem cell using human stromal cells

    Ketsueki Syuyouka   47   479 - 2003   2003

    　More details

  • Protection of human lung cells against hyperoxia using the DNA base excision repair genes hOgg1 and Fpg

    M Wu, YH He, M Kobune, Y Xu, MR Kelley, WJ Martin

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   166 ( 2 )   192 - 199   2002.7

    　More details

  • Denatured H-ferritin subunit is a major constituent of haemosiderin in the liver of patients with iron overload

    E Miyazaki, J Kato, M Kobune, K Okumura, K Sasaki, N Shintani, P Arosio, Y Niitsu

    GUT   50 ( 3 )   413 - 419   2002.3

    　More details

  • Ratio of transferrin (Tf) to Tf-receptor complex in circulation differs depending on Tf iron saturation

    J Kato, M Kobune, Y Kohgo, K Fujikawa, R Takimoto, Y Torimoto, Y Ito, M Bessho, T Hotta, A Hikawa, T Fujii, K Punnonen, Y Niitsu

    CLINICAL CHEMISTRY   48 ( 1 )   181 - 183   2002.1

    　More details

    Language：English   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)  

    Web of Science

    researchmap

  • 細胞接着とマトリックス・βカテニンの多彩な機能

    分子細胞治療   1   61 - 65   2002

    　More details

  • Normalization of elevated hepatic 8-hydroxy-2 '-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet

    J Kato, M Kobune, T Nakamura, G Kuroiwa, K Takada, R Takimoto, Y Sato, K Fujikawa, M Takahashi, T Takayama, T Ikeda, Y Niitsu

    CANCER RESEARCH   61 ( 24 )   8697 - 8702   2001.12

    　More details

    Language：English  

    Web of Science

    researchmap

  • Expression of yeast apurinic/apyrimidinic endonuclease (APN1) protects lung epithelial cells from bleomycin toxicity

    YH He, M Wu, M Kobune, Y Xu, MR Kelley, WJ Martin

    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY   25 ( 6 )   692 - 698   2001.12

    　More details

    Language：English  

    Web of Science

    researchmap

  • Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N ',N ''-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo

    M Kobune, Y Xu, C Baum, MR Kelley, DA Williams

    CANCER RESEARCH   61 ( 13 )   5116 - 5125   2001.7

    　More details

    Language：English  

    Web of Science

    researchmap

  • A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload

    J Kato, K Fujikawa, M Kanda, N Fukuda, K Sasaki, T Takayama, M Kobune, K Takada, R Takimoto, H Hamada, T Ikeda, Y Niitsu

    AMERICAN JOURNAL OF HUMAN GENETICS   69 ( 1 )   191 - 197   2001.7

    　More details

  • GST-pi gene-transduced hematopoietic progenitor cell transplantation overcomes the bone marrow toxicity cyclophosphamide in mice

    T Matsunaga, S Sakamaki, T Kuga, H Kuroda, T Kusakabe, T Akiyama, Y Konuma, Y Hirayama, M Kobune, J Kato, K Sasaki, K Kogawa, R Koyama, Y Niitsu

    HUMAN GENE THERAPY   11 ( 12 )   1671 - 1681   2000.8

    　More details

    Language：English  

    Web of Science

    researchmap

  • Transforming growth factor-beta 1 (TGF-beta 1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itself with high specificity

    S Sakamaki, Y Hirayama, T Matsunaga, H Kuroda, T Kusakabe, T Akiyama, Y Konuma, K Sasaki, N Tsuji, T Okamoto, M Kobune, K Kogawa, J Kato, R Takimoto, R Koyama, Y Niitsu

    BLOOD   94 ( 6 )   1961 - 1970   1999.9

    　More details

    Language：English  

    Web of Science

    researchmap

  • 消化器疾患 8.血液・造血器疾患 C.フェロキネティクス

    内科学教科書   3   1275 - 1277   1999

    　More details

  • Ferrokinetics

    Textbook of internal medicine   3   1275 - 1277   1999

    　More details

  • Suppressive effect of ethanol on the expression of hepatic asialoglycoprotein receptors augmented by interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha

    J Kato, Y Mogi, Y Kohgo, R Takimoto, M Kobune, H Hisai, T Nakamura, K Takada, Y Niitsu

    JOURNAL OF GASTROENTEROLOGY   33 ( 6 )   855 - 859   1998.12

    　More details

  • Hemochromatosis

    J. Kato, M. Kobune, Y. Niitsu

    Ryōikibetsu shōkōgun shirīzu   ( 19 )   178 - 181   1998

    　More details

    Language：Japanese   Publishing type：Book review, literature introduction, etc.  

    PubMed

    researchmap

  • INTERLEUKIN-6 ENHANCES HEPATIC TRANSFERRIN UPTAKE AND FERRITIN EXPRESSION IN RATS

    M KOBUNE, Y KOHGO, J KATO, E MIYAZAKI, Y NIITSU

    HEPATOLOGY   19 ( 6 )   1468 - 1475   1994.6

    　More details

  • ABNORMAL HEPATIC IRON ACCUMULATION IN LEC RATS

    J KATO, Y KOHGO, N SUGAWARA, S KATSUKI, N SHINTANI, K FUJIKAWA, E MIYAZAKI, M KOBUNE, N TAKEICHI, Y NIITSU

    JAPANESE JOURNAL OF CANCER RESEARCH   84 ( 3 )   219 - 222   1993.3

    　More details

    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    Web of Science

    researchmap

  • Mesenchymal stem cells (MSC) as thepapeutic cytoreagents for gene therapy

    Development of neuroscience  

    　More details

▼display all

Research Projects

  • 骨髄微細環境における神経－白血病系の解析

    Grant number：24K11546  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    堀口 拓人, 後藤 亜香利, 小船 雅義

    　 More details

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

    researchmap

  • がん化学療法時の栄養状態に関わる腸管機能モニタリングの確立

    Grant number：23K10848  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    井山 諭, 小船 雅義, 高田 弘一

    　 More details

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

    １）院内での倫理委員会申請許可後より，患者保存資料を用いた研究を開始している。ジアミンオキシダーゼ値に関してはELISAシステムによる測定を開始した。測定の結果，同種造血幹細胞移植に伴う前処置（大量化学療法）の後，血中ジアミンオキシダーゼ値は一時的に低下し，多くの場合2週間後に最低値となることが分かった。これは患者が前処置に伴い経口栄養摂取不良状態になる時期と一致しており，腸管機能モニタリングに有用である可能性が示唆された。経過としては，腸管機能が良好に保たれる患者の場合には，おおよそday14以降で緩やかな改善を認めるが，腸管機能に問題がある場合にはジアミンオキシダーゼ値の回復遅延が見られることが分かった。
    ２）次世代シークエンサーを用いた腸内細菌叢検査は20検体施行した。経過で細菌叢の推移が見られる症例や，移植開始時点ですでに顕著なdysbiosisが見られる症例があることが判明した。しかしながら検出される細菌の種類には一定の傾向はなく，患者間でばらつきがあることが分かった。
    今後ジアミンオキシダーゼ値の測定以外に，活性値の測定と実測値との違いに関する検討を加えたいと考えている。また，腸内細菌叢の関係や，移植後の移植片対宿主病（GVHD）の関連性などに関しても患者情報と照らし合わせた調査を続けたいと考えている。

    researchmap

  • 骨髄および臍帯血由来間葉系幹細胞を用いた再生医療

    　 More details

    Grant type：Competitive

    researchmap

  • 造血幹細胞の遺伝子改変を安全に行うための治療用ベクターの開発

    　 More details

    Grant type：Competitive

    researchmap

  • Wnt/Hedgehogシグナルによる造血器腫瘍の治療抵抗性誘導機構の解明

    　 More details

    Grant type：Competitive

    researchmap

  • 骨髄由来幹細胞の分化制御と大量培養系の確立

    　 More details

    Grant type：Competitive

    researchmap

▼display all