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  1988年

  札幌医科大学  

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  1988年

  札幌医科大学  

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• 博士 (医学)

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  Japanese Society of Endourology and ESWL

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  米国泌尿器科学会

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  Japanese Cancer Association

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  日本排尿機能学会

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  Japan Society of Clinical Oncology

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• 札幌医科大学   医学部 医学科 泌尿器科学講座 医学部医学科臨床医学部門講座泌尿器科学講座   教授  

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• 泌尿器科学

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• Web-based research of lower urinary tract symptoms that affect quality of life in elderly Japanese men: analysis using a structural equation model

  N Masumori, D Homma, T Tsukamoto

  BJU INTERNATIONAL ( BLACKWELL PUBLISHING LTD )  95 ( 7 ) 1013 - 1022  2005年05月

  　概要を見る

  OBJECTIVE To investigate the distribution of lower urinary tract symptoms (LUTS) in elderly Japanese men, to clarify which variables contributed to medical care-seeking behaviour, and to construct a structural-equation model (SEM) to explain overall quality of life (QoL). SUBJECTS AND METHODS A dataset was obtained from 662 Japanese men aged 50-79 years who participated in the programme by accessing a website via the Internet between 10.30 hours on 19 February 2003 and 10.30 hours on 24 February 2003. The participants were queried about their International Prostate Symptom Score (IPSS), bother, QoL index and medical care-seeking behaviour. RESULTS Of the 662 participants, 314 reported intending to seek medical care for LUTS (intention group); the remaining 348 answered that they did not intend to see a doctor (no-intention group). The characteristic of weak stream had the strongest correlation with the QoL index, not only in the intention (r = 0.58) but also in the no-intention group (r = 0.48). Among several SEMs proposed, one that included a latent variable termed 'QoL sensitivity' was the most appropriate to explain overall QoL. In this model it was assumed that 'QoL sensitivity' was affected by other latent variables, termed the 'voiding symptom factors' and 'storage symptom factors', and affected the degree of bother related to each symptom. CONCLUSION In Japanese men, voiding symptoms, especially weak stream, contributed to overall QoL for medical care-seeking behaviour. Differences in 'QoL sensitivity' among men may be one of the reasons why symptomatic severity is not always correlated with symptom-related bother.

  DOI

• Ligands for peroxisome proliferator-activated receptor gamma have potent antitumor effect against human renal cell carcinoma

  JY Yuan, A Takahashi, N Masumori, K Uchida, SI Hisasue, H Kitamura, N Itoh, T Tsukamoto

  UROLOGY ( ELSEVIER SCIENCE INC )  65 ( 3 ) 594 - 599  2005年03月

  　概要を見る

  Objectives. To examine whether peroxisome proliferator-activated receptor gamma (PPAR gamma) is expressed in human renal cell carcinoma (RCC) cells, and whether activation of PPAR gamma by its ligands can have multiple antitumor effects on human RCC cells in vitro. Methods. We examined the expression of PPAR gamma in four human RCC cell lines by reverse transcriptase-polymerase chain reaction and immunocytochemical staining. The effects of two PPAR gamma ligands, pioglitazone and 15-deoxy-Delta 12,14-prostaglandin J(2), on cell proliferation were investigated by 3-[4,5-dimethylthiazol-2thiazoly]-2,5-diphenyltetrazolium bromide assay. The induction of apoptosis by the ligands was examined using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling method and Annexin V assay. Furthermore, we investigated whether these ligands suppressed the production of angiogenic factors, vascular endothelial growth factor and basic fibroblast growth factor, by enzyme-linked immunosorbent assay. Results. PPAR gamma and retinoid X receptor, which forms a heterodimer with PPAR gamma, were expressed in all RCC cell lines. In addition, immunocytochemical studies showed expression of PPAR gamma protein in the RCC cells. PPAR gamma ligands inhibited the cell growth in all cells in a dose-dependent manner. These ligands also induced apoptosis. Furthermore, secretion of both vascular endothelial growth factor and basic fibroblast growth factor was inhibited by these ligands in a dose-dependent and time-dependent manner. Conclusions. Ligands for PPAR gamma have multiple antitumor effects in human RCC cells in vitro. Activation of the PPAR gamma pathway may be a new strategy for treatment of patients with RCC. (c) 2005 Elsevier Inc.

  DOI

• Characterization of prostatic neuroendocrine cell line established from neuroendocrine carcinoma of transgenic mouse allograft model

  K Uchida, N Masumori, A Takahashi, N Itoh, T Tsukamoto

  PROSTATE ( WILEY-LISS )  62 ( 1 ) 40 - 48  2005年01月

  　概要を見る

  BACKGROUND. The role of neuroendocrine (NE) cells in prostate cancer remains unclear. A useful model is necessary to study the biology of NE cells. We herein describe the establishment and characterization of an immortalized cell line from an NE-10 allograft of murine prostatic NE carcinoma. METHODS. A novel cell line, designated NE-CS, was developed from an NE-10 allograft that was established from the ventral prostate of the LPB-T-antigen (Tag) transgenic mouse, line 10 (12T-10). We investigated the growth, karyotype, electron microscopic findings, expression of Tag and androgen receptor (AR), and tumorigenesis of the cells in athymic mice. RESULTS. The immortal cell line NE-CS was maintained in vitro for more than 2 years. The NE-CS cells had dendritic-like extensions with dense core granules in the cytoplasm and produced serotonin and somatostatin in conditioned medium. The cells expressed neither Tag nor AR. They showed androgen-independent growth in vitro and a hypotetraploid karyotype similar to the original NE-10 allograft. The NE-CS cells, which were subcutaneously inoculated into athymic mice, formed tumors with the NE phenotype. The tumors exhibited accelerated growth compared to the original NE-10 allograft. CONCLUSIONS. The established cell line has characteristics of NE differentiation and tumorigenic ability. This cell line may be a promising model to understand the molecular mechanisms associated with the acquisition of hormone refractory prostate cancer. (C) 2004 Wiley-Liss, Inc.

  DOI

• Prevalence of female sexual dysfunction symptoms and its relationship to quality of life: A Japanese female cohort study

  S Hisasue, Y Kumamoto, Y Sato, N Masumori, H Horita, R Kato, K Kobayashi, K Hashimoto, N Yamashita, N Itoh

  UROLOGY ( ELSEVIER SCIENCE INC )  65 ( 1 ) 143 - 148  2005年01月

  　概要を見る

  Objectives. To clarify the age prevalence of female sexual dysfunction and the factors that contribute to the varying frequency of sexual intercourse and satisfaction with sexual life in Japanese women. Methods. Of 8956 participants (median age 57 years, range 17 to 88) in a Japanese female cohort study, 5042 (56.3%) responded. We evaluated 2095 women aged 30 to 69 years (median 48) who completed a questionnaire that queried about their sexual life. Results. When women in their 30s were compared with those in their 60s. we found that the prevalence of the symptom of orgasmic disorder, sexual desire disorder, arousal disorder, and lubrication disorder had increased significantly from 15.2% to 32.2%, 27.7% to 57.9%, 29.7% to 57.9%, and 12.5% to 51.2%, respectively. Multivariate analysis showed that the rigidity of the partner's erection, orgasm. and arousal contributed significantly to sexual frequency and foreplay and orgasm to satisfaction with sexual life. Conclusions. The prevalence of female sexual dysfunction increased with age. The results of multivariate analysis indicated that favorable sexual function is important to maintain the opportunity for sexual intercourse in both men and women and that foreplay and orgasm are essential for satisfactory sexual life in women. (C) 2005 Elsevier Inc.

  DOI

• Bladder cancer discovered by ovarian metastasis: cytokeratin expression is useful when making differential diagnosis.

  Int J Urol   12 ( 1 ) 104 - 107  2005年

  DOI PubMed CiNii

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• 前立腺癌のホルモン不応性の機序

• 泌尿器癌

• 前立腺肥大症の疫学

• 性同一性障害