2025/08/22 更新

写真a

イチカワ　リョウイチ
市川　量一
所属
医学部 解剖学講座細胞組織学分野 准教授
職名
准教授
外部リンク

学位

  • 博士（医学）

研究キーワード

  • 神経生物学 神経解剖学

研究分野

  • ライフサイエンス / 神経形態学

学歴

  • 北海道大学

    - 1990年

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    国名： 日本国

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  • 北海道大学

    - 1990年

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所属学協会

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論文

  • Two patterns in apical dendrite extensions of projection neurons within cerebral cortex of reeler mutant mice. 国際誌

    Ryoichi Ichikawa

    Frontiers in neuroanatomy   19   1560972 - 1560972   2025年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    INTRODUCTION: Pyramidal-like projection neurons in the cerebral cortex exhibit layer-specific positioning of their cell bodies and target specific cortical regions with their apical dendrites. Reeler mutant mice, which lack the gene for the reelin protein gene secreted by Cajal-Retzius cells and have their projection neurons scattered throughout the cortex, display relatively intact global and local neuronal network connections compared with wild-type mice. The irregular morphologies of these cells, which extend their apical dendrites in a neuron-disoriented direction, are thought to compensate for the malposition of the neurons. I aimed to investigate the projection target-specific regulation of this apical dendrite extension pattern in reeler mice. METHODS: To this end, three types of projection neurons-corticospinal (CS), corticothalamic (CT), and corticocallosal (CC) neurons-were evaluated using retrograde labeling techniques. RESULTS AND DISCUSSION: Reeler CS neurons displayed a congregation pattern of apical dendritic terminal tips in a specific upper cortical zone, whereas reeler CC neurons exhibited a dispersed pattern of scattered tips throughout the cortex. However, reeler CT neurons showed a hybrid pattern, exhibiting characteristics of both congregation- and dispersion-type neurons. Moreover, apical dendrite extension of these projection neurons follows either a congregation or dispersion mode from postnatal day 0 (P0), which subsequently defines their terminal tip positioning by P8. Thus, this early patterning of apical dendrite arborization in reeler projection neurons likely contributes to the formation of projection target-specific neuronal connections during the first two postnatal weeks.

    DOI： 10.3389/fnana.2025.1560972

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  • GluD2 Endows Parallel Fiber-Purkinje Cell Synapses with a High Regenerative Capacity 査読 国際誌

    Ryoichi Ichikawa, Kenji Sakimura, Masahiko Watanabe

    JOURNAL OF NEUROSCIENCE   36 ( 17 )   4846 - 4858   2016年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1523/JNEUROSCI.0161-16.2016

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  • Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination 査読 国際誌

    Ryoichi Ichikawa, Kouichi Hashimoto, Taisuke Miyazaki, Motokazu Uchigashima, Miwako Yamasaki, Atsu Aiba, Masanobu Kano, Masahiko Watanabe

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   113 ( 8 )   2282 - 2287   2016年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1073/pnas.1511513113

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  • Developmental Switching of Perisomatic Innervation from Climbing Fibers to Basket Cell Fibers in Cerebellar Purkinje Cells 査読 国際誌

    Ryoichi Ichikawa, Miwako Yamasaki, Taisuke Miyazaki, Kohtarou Konno, Kouichi Hashimoto, Haruyuki Tatsumi, Yoshiro Inoue, Masanobu Kano, Masahiko Watanabe

    JOURNAL OF NEUROSCIENCE   31 ( 47 )   16916 - 16927   2011年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1523/JNEUROSCI.2396-11.2011

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  • Developmental switching of perisomatic innervation from climbing fibers to basket cell fibers in developing cerebellar purkinje cells 査読

    Ryoichi Ichikawa, Miwako Yamasaki, Taisuke Miyazaki, Haruyuki Tatsumi, Masahiko Watanabe

    NEUROSCIENCE RESEARCH   71   E215 - E215   2011年

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  • Translocation of a "Winner" Climbing Fiber to the Purkinje Cell Dendrite and Subsequent Elimination of "Losers" from the Soma in Developing Cerebellum 査読 国際誌

    Kouichi Hashimoto, Ryoichi Ichikawa, Kazuo Kitamura, Masahiko Watanabe, Masanobu Kano

    NEURON   63 ( 1 )   106 - 118   2009年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.neuron.2009.06.008

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  • Distal Extension of Climbing Fiber Territory and Multiple Innervation Caused by Aberrant Wiring to Adjacent Spiny Branchlets in Cerebellar Purkinje Cells Lacking Glutamate Receptor GluR2 査読

    市川 量一

    J Neurosci,   22 ( 19 )   8487 - 8503   2002年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Web of Science

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MISC

  • mGluR1 Sculpts Heterologous Inputs to Cerebellar Purkinje Cells

    R. Ichikawa, M. Watanabe

    CURRENT NEUROPHARMACOLOGY   12   28 - 28   2014年

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

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  • 発達期小脳プルキンエ細胞でみられる細胞体シナプスの入力線維のスイッチング-登上線維から籠細胞線維へ

    市川 量一, 山崎 美和子, 宮崎 太輔, 今野 幸太郎, 橋本 浩一, 辰巳 治之, 井上 芳郎, 狩野 正伸, 渡辺 雅彦

    北海道醫學雜誌 = Acta medica Hokkaidonensia   87 ( 2 )   73 - 73   2012年4月

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    記述言語：日本語  

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  • 学内研究紹介 シナプス構築の形成機構--小脳プルキンエ細胞を中心に

    市川 量一, 岩村 広太, 菊池 真, 新見 隆彦, 二宮 孝文, 辰巳 治之

    札幌医学雑誌   77 ( 1 )   1 - 6   2008年12月

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    記述言語：日本語   出版者・発行元：札幌医科大学  

    Proper synaptic organization contributes crucial role in generating proper neuronal output. This article reviews a series of experiments aimed at investigating mechanism of formation of proper synaptic organization in cerebellar Purkinje cell (PC). Maturated PC receives two types of excitatory inputs, parallel fibers (PF) and climbing fiber, in segregated dendritic domain. During developing period, PF synapses induce elongation of PC dendrites and move to the elongated portion, and CF translocates along PC dendrite after PF synapses. PF and CF compete for spine to form synaptic contact and newly formed synapse is likely to be stabilized if it is to be proper. Furthermore, occupation of spines by PF synapses prevents from multiply CF innervation on PC dendrites. At adult, CF acts to maintain completed synaptic organization. In addition, the molecular that involve in the stabilization of excitatory synapses on PC have been reported.

    DOI： 10.15114/smj.77.1

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  • The appearance of aprataxin in rat cultured neuron and glia

    Takafumi Ninomiya, Shin Kikuchi, Ryoichi Ichikawa, Naoki Kozuka, Nobutada Tachi, Haruyuki Tatsumi

    NEUROSCIENCE RESEARCH   58   S139 - S139   2007年

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

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  • Transient neonatal expression of NR2B/2D subunit mRNAs of the N-methyl-D-aspartate receptor in the parasympathetic preganglionic neurons in the rat spinal cord 国際誌

    T Shibata, M Watanabe, R Ichikawa, K Ameda, T Koyanagi

    DEVELOPMENTAL BRAIN RESEARCH   140 ( 2 )   263 - 268   2003年2月

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  • Ovariectomy attenuates hyperpolarization and relaxation mediated by endothelium-derived hyperpolarizing factor in female rat mesenteric artery: A concomitant decrease in connexin-43 expression 国際誌

    MY Liu, Y Hattori, A Sato, R Ichikawa, XH Zhang, Sakuma, I

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   40 ( 6 )   938 - 948   2002年12月

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  • Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor delta 2. 国際誌

    Ryoichi Ichikawa, Taisuke Miyazaki, Masanobu Kano, Tsutomu Hashikawa, Haruyuki Tatsumi, Kenji Sakimura, Masayoshi Mishina, Yoshiro Inoue, Masahiko Watanabe

    J Neurosci   22 ( 19 )   8487 - 503   2002年

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    記述言語：英語  

    Organized synapse formation on to Purkinje cell (PC) dendrites by parallel fibers (PFs) and climbing fibers (CFs) is crucial for cerebellar function. In PCs lacking glutamate receptor delta2 (GluRdelta2), PF synapses are reduced in number, numerous free spines emerge, and multiple CF innervation persists to adulthood. In the present study, we conducted anterograde and immunohistochemical labelings to investigate how CFs innervate PC dendrites under weakened synaptogenesis by PFs. In the GluRdelta2 knock-out mouse, CFs were distributed in the molecular layer more closely to the pial surface compared with the wild-type mouse. Serial electron microscopy demonstrated that CFs in the knock-out mouse innervated all spines protruding from proximal dendrites of PCs, as did those in the wild-type mouse. In the knock-out mouse, however, CF innervation extended distally to spiny branchlets, where nearly half of the spines were free of innervation in contrast to complete synapse formation by PFs in the wild-type mouse. Furthermore, from the end point of innervation, CFs aberrantly jumped to form ectopic synapses on adjacent spiny branchlets, whose proximal portions were often innervated by different CFs. Without GluRdelta2, CFs are thus able to expand their territory along and beyond dendritic trees of the target PC, resulting in persistent surplus CFs by innervating the distal dendritic segment. We conclude that GluRdelta2 is essential to restrict CF innervation to the proximal dendritic segment, by which territorized innervation by PFs and CFs is properly structured and the formation of excess CF wiring to adjacent PCs is suppressed.

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  • Roles of glutamate receptor delta 2 subunit (GluR delta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development

    K Hashimoto, R Ichikawa, H Takechi, Y Inoue, A Aiba, K Sakimura, M Mishina, T Hashikawa, A Konnerth, M Watanabe, M Kano

    JOURNAL OF NEUROSCIENCE   21 ( 24 )   9701 - 9712   2001年12月

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    記述言語：英語  

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  • Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule

    K Nakamura, T Manabe, M Watanabe, T Mamiya, R Ichikawa, Y Kiyama, M Sanbo, T Yagi, Y Inoue, T Nabeshima, H Mori, M Mishina

    EUROPEAN JOURNAL OF NEUROSCIENCE   13 ( 1 )   179 - 189   2001年1月

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  • Preferential impairment of nitric oxide-mediated endothelium-dependent relaxation in human cervical arteries after irradiation

    T Sugihara, Y Hattori, Y Yamamoto, FH Qi, R Ichikawa, A Sato, MY Liu, K Abe, M Kanno

    CIRCULATION   100 ( 6 )   635 - 641   1999年8月

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    記述言語：英語  

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  • Different expressions of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and N-methyl-D-aspartate receptor subunit mRNAs between visceromotor and somatomotor neurons of the rat lumbosacral spinal cord

    T Shibata, M Watanabe, R Ichikawa, Y Inoue, T Koyanagi

    JOURNAL OF COMPARATIVE NEUROLOGY   404 ( 2 )   172 - 182   1999年2月

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  • Early establishment of lesion-insensitive mature barrelettes corresponding to upper lip vibrissae in developing mice

    S Toki, M Watanabe, R Ichikawa, T Shirakawa, H Oguchi, Y Inoue

    NEUROSCIENCE RESEARCH   33 ( 1 )   9 - 15   1999年1月

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  • 終脳特異的細胞接着分子テレンセファリン欠損マウスの解析

    中村和裕, 森寿, 城山優治, 三宝誠, 八木健, 真鍋俊也, 高橋智幸, 渡辺雅彦, 市川量一, 井上芳郎, 三品昌美

    日本分子生物学会年会プログラム・講演要旨集   21   1998年12月

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  • テレンセファリン遺伝子にCreリコンビナーゼ遺伝子を挿入した変異マウスの作製と解析

    中村 和裕, 森 寿, 城山 優治, 八木 健, 真鍋 俊也, 高橋 智幸, 渡辺 雅彦, 市川 量一, 井上 芳郎, 三品 昌美

    神経化学   37 ( 3 )   555 - 555   1998年9月

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    記述言語：日本語   出版者・発行元：(一社)日本神経化学会  

    医中誌

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  • リ−ラ−マウスを用いた皮質投射ニュ−ロンの計量形態学的解析

    北海道医学雑誌   73   73 - 87   1998年

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  • リーラーマウスを用いた皮質投射ニューロンの計量形態学的解析

    市川 量一

    北海道醫學雜誌 = Acta medica Hokkaidonensia   73 ( 1 )   73 - 87   1998年

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    記述言語：日本語  

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  • Extra-junctional localization of glutamate transporter EAAT4 at excitatory Purkinje cell synapses

    J Tanaka, R Ichikawa, M Watanabe, K Tanaka, Y Inoue

    NEUROREPORT   8 ( 11 )   2461 - 2464   1997年7月

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    記述言語：英語  

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  • CEREBELLUM OF THE ADULT REELER MUTANT MOUSE CONTAINS 2 PURKINJE-CELL POPULATIONS WITH RESPECT TO GENE-EXPRESSION FOR THE N-METHYL-D-ASPARTATE RECEPTOR-CHANNEL

    M WATANABE, S NAKAGAWA, C TAKAYAMA, M NAGASHIMA, K INOUE, R ICHIKAWA, M MISHINA, Y INOUE

    NEUROSCIENCE RESEARCH   22 ( 3 )   335 - 345   1995年6月

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  • Sex Differences in the Shapes of Several Parts of the Young Japanese Face :

    Inoue Kaoru, lchikawa Ryoichi, Nagashima Masabumi, Kodama Jeorge

    Applied human science : journal of physiological anthropology   14 ( 4 )   191 - 194   1995年

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    記述言語：英語   出版者・発行元：Japan Society of Physiological Anthropology  

    その他リンク:： http://search.jamas.or.jp/link/ui/1996066920

    DOI： 10.2114/ahs.14.191

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  • DEVELOPMENTAL STUDIES ON THE INTERPARIETAL PART OF THE HUMAN OCCIPITAL SQUAMA

    G MATSUMURA, T UCHIUMI, K KIDA, R ICHIKAWA, G KODAMA

    JOURNAL OF ANATOMY   182   197 - 204   1993年4月

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  • DISTRIBUTION OF GUANINE NUCLEOTIDE-BINDING PROTEIN IN THE BRAIN OF THE REELER MUTANT MOUSE

    T TERASHIMA, T KATADA, R ICHIKAWA, M UI, Y INOUE

    BRAIN RESEARCH   601 ( 1-2 )   136 - 142   1993年1月

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  • ABNORMAL SYNAPTIC ARCHITECTURE IN THE CEREBELLAR CORTEX OF A NEW DYSTONIC MUTANT MOUSE, WRIGGLE MOUSE SAGAMI

    Y INOUE, Y MATSUMURA, K INOUE, R ICHIKAWA, C TAKAYAMA

    NEUROSCIENCE RESEARCH   16 ( 1 )   39 - 48   1993年1月

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  • Dendritic Arbolization of Large Pyramidal Neurons in the Motor Cortex of Normal and Reeler Mutant Mouse

    Toshio Terashima, Chitoshi Takayama, Ryoichi Ichikawa, Yoshiro Inoue

    Okajimas Folia Anatomica Japonica   68 ( 6 )   351 - 363   1992年

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  • 日本人頭蓋における翼上骨ならびにプテリオン−とくに形成と形態変異を中心として

    解剖学雑誌   66   462 - 71   1991年

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  • [Pterion and epipteric bones in Japanese adults and fetuses, with special reference to their formation and variations]

    Kaibogaku Zasshi.   66   462 - 71   1991年

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受賞

  • 北海道医学会賞

    1999年  

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共同研究・競争的資金等の研究課題

  • 小脳プルキンエ細胞上のシナプス構築形成機構の解明

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    資金種別：競争的資金

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  • リーラーマウス大脳皮質投射神経細胞の形態形成の解明

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    資金種別：競争的資金

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