Updated on 2025/08/05

写真a

 
ISHIGURO Masanori
 
Organization
School of Medicine Department of Neuroscience Assistant Professor
Title
Assistant Professor
Profile
sapporo med university
External link

Research Interests

  • 遺伝子

  • myogenic tone

  • vascular smooth muscle

  • cerebral artery

  • 5-HT2_A

  • 脳血管

  • 脳神経疾患

  • イオンチャネル

  • 生理学

  • seronin

  • 運動系神経生理学

Research Areas

  • Life Science / Neurosurgery

Papers

  • The Role of Aquaporin 1 in Water Retention Mechanism of Arachnoid Cysts: Insights from 3 Case Reports. International journal

    Yasutaka Kurokawa, Masanori Ishiguro, Takayuki Kurokawa

    The American journal of case reports   24   e939834   2023.7

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    BACKGROUND Although arachnoid cysts are common lesions, the pathogenesis of their continuous growth remains unclear. We aimed to identify the role of aquaporins in arachnoid cyst specimens. CASE REPORT We selected 3 cases from our own facility and examined arachnoid cyst wall specimens, which were sampled intraoperatively. Patients presented with variable symptoms, a 52-year-old man with a "heavy sensation" in the head and dysesthesia on the left hand, a 68-year-old man with unsteady gait, and finally a 26-year-old woman with a history of intermittent headaches for 10 years. Intraoperative specimens were obtained and examined. Evaluation techniques were light microscopy, immunohistochemical staining for aquaporin, and electron microscopy. Light microscopy showed that cells were arranged in epithelium-like structures forming several thick lamellae, with visible connective tissue among them. Under electron microscopic examination, cells with many or few cell organelles and with spindle-like nuclei were arranged in lamellar or flattened structures. Many vacuolizations were seen in between. Interdigitation of cells and many desmosomes were observed. All 3 cases were positive for aquaporin 1. CONCLUSIONS Our study showed that water transportation through aquaporin 1 has a potential role in the formation and expansion of arachnoid cysts.

    DOI： 10.12659/AJCR.939834

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  • Dexmedetomidine improves excessive extracellular glutamate-induced synaptic depression (BRAINRES-D-21-00941)

    Eichi Narimatsu, Ryuichiro Kakizaki, Kazuhito Nomura, Keigo Sawamoto, Kazunobu Takahashi, Shuji Uemura, Masanori Ishiguro

    BRAIN RESEARCH   1789   2022.8

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    DOI： 10.1016/j.brainres.2022.147949

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  • 電流源推定に使用するMEGセンサーの選択範囲による影響に関する検討

    齊藤 秀和, 菅原 和広, 臼井 桂子, 篠崎 淳, 石黒 雅敬, 白石 秀明, 松橋 眞生, 長峯 隆

    日本生体磁気学会誌   35 ( 1 )   94 - 95   2022

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    Language：Japanese   Publisher：日本生体磁気学会  

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  • 生体磁気計測関係のアーチファクト MEG計測において歯科矯正器具によるArtifactを認めた一例

    齊藤 秀和, 菅原 和広, 臼井 桂子, 篠崎 淳, 石黒 雅敬, 白石 秀明, 松橋 眞生, 長峯 隆

    日本生体磁気学会誌   35 ( 1 )   48 - 49   2022

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    Ichushi

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  • Effects of propofol on IPSCs in CA1 and dentate gyrus cells of rat hippocampus: Propofol effects on hippocampal cells' IPSCs. Reviewed

    Ishiguro M, Kobayashi S, Matsuyama K, Nagamine T

    Neuroscience research   143   13 - 19   2018.5

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    DOI： 10.1016/j.neures.2018.05.003

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  • Load effect on background rhythms during motor execution: A magnetoencephalographic study Reviewed

    Takanobu Toyoshima, Shogo Yazawa, Takashi Murahara, Masanori Ishiguro, Jun Shinozaki, Satoe Ichihara-Takeda, Hideaki Shiraishi, Masao Matsuhashi, Shun Shimohama, Takashi Nagamine

    NEUROSCIENCE RESEARCH   112   26 - 36   2016.11

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    DOI： 10.1016/j.neures.2016.06.002

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  • Modulation of Alpha Activity in the Parieto-occipital Area by Distractors during a Visuospatial Working Memory Task: A Magnetoencephalographic Study Reviewed

    Satoe Ichihara-Takeda, Shogo Yazawa, Takashi Murahara, Takanobu Toyoshima, Jun Shinozaki, Masanori Ishiguro, Hideaki Shiraishi, Nozomu Ikeda, Kiyoji Matsuyama, Shintaro Funahashi, Takashi Nagamine

    JOURNAL OF COGNITIVE NEUROSCIENCE   27 ( 3 )   453 - 463   2015.3

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  • Sarpogrelate Dilates Cerebral Arteries in the Absence of Exogenous Serotonin Reviewed

    Maiko Kawamura, Masanori Ishiguro, Takashi Nagamine, Kiyohiro Houkin

    NEUROLOGIA MEDICO-CHIRURGICA   53 ( 5 )   291 - 298   2013.5

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    DOI： 10.2176/nmc.53.291

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  • Cellular basis of vasospasm: role of small diameter arteries and voltage-dependent Ca2+ channels Reviewed

    M. Ishiguro, G. C. Wellman

    CEREBRAL VASOSPASM: NEW STRATEGIES IN RESEARCH AND TREATMENT   104   95 - 98   2008

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  • Acute and chronic effects of oxyhemoglobin on voltage-dependent ion channels in cerebral arteries Reviewed

    M. Ishiguro, K. Murakami, T. Link, K. Zvarova, B. I. Tranmer, A. D. Morielli, G. C. Wellman

    CEREBRAL VASOSPASM: NEW STRATEGIES IN RESEARCH AND TREATMENT   104   99 - +   2008

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  • Oxyhemoglobin-induced suppression of voltage-dependent K(+) channels in cerebral arteries by enhanced tyrosine kinase activity Reviewed

    Masanori Ishiguro, Anthony D. Morielli, Katarina Zvarova, Bruce I. Tranmer, Paul L. Penar, George C. Wellman

    CIRCULATION RESEARCH   99 ( 11 )   1252 - 1260   2006.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/01.RES.0000250821.32324.e1

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  • Emergence of a R-type Ca2+ channel (Ca-V 2.3) contributes to cerebral artery constriction after subarachnoid hemorrhage Reviewed

    M Ishiguro, TL Wellman, A Honda, Russell, SR, BI Tranmer, GC Wellman

    CIRCULATION RESEARCH   96 ( 4 )   419 - 426   2005.3

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    DOI： 10.1161/01.RES.0000157970.49936.a

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  • Enhanced myogenic tone in cerebral arteries from a rabbit model of subarachnoid hemorrhage Reviewed

    M Ishiguro, CB Puryear, E Bisson, CM Saundry, DJ Nathan, Russell, SR, BI Tranmer, GC Wellman

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   283 ( 6 )   H2217 - H2225   2002.12

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    DOI： 10.1152/ajpheart.00629.2002

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  • New method for obliterative treatment of an anterior wall aneurysm in the internal carotid artery: Encircling silicone sheet clip procedure - Technical case report Reviewed International journal

    Y Kurokawa, M Wanibuchi, M Ishiguro, K Inaba

    NEUROSURGERY   49 ( 2 )   469 - 472   2001.8

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  • Characteristics of aneurysms arising from the horizontal portion of the anterior cerebral artery. Reviewed International journal

    Wanibuchi M, Kurokawa Y, Ishiguro M, Fujishige M, Inaba K

    Surgical neurology   55 ( 3 )   148 - 54; discussion 154   2001.3

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    BACKGROUND: Aneurysms arising from the proximal portion of the anterior cerebral artery (A1: horizontal portion) are quite rare and are considered to be unique, because they are usually connected with other vascular anomalies and are sometimes part of a multiple aneurysm occurrence. A1 aneurysm cases experienced over the past seven and a half years are summarized in this paper. METHODS: A total of 413 patients were surgically treated including 142 patients with subarachnoid hemorrhage (SAH); the remaining 271 patients had unruptured aneurysms. Among them, nine cases were categorized as constituent A1 aneurysms, three with SAH and six with unruptured aneurysms. RESULTS: The shape of the aneurysm was saccular in all nine cases. Three of the nine cases had associated vascular malformations. The average aneurysm diameter in the three cases with SAH was 4.0 mm, which is smaller than other common aneurysms presenting with SAH. Eight aneurysms developed at the takeoff point of perforating arteries-the medial lenticulostriate artery in five cases and the recurrent artery of Heubner in three cases. In the remaining case, the aneurysm originated from the proximal end of the associated A1 fenestration. All nine patients had an excellent outcome after surgery. CONCLUSION: A1 aneurysms require surgical elimination even if they are small. We emphasize the importance of preserving the blood flow of these perforating arteries by avoiding compression with either the clip blade or the clip body itself.

    DOI： 10.1016/s0090-3019(01)00396-2

    DOI： 10.2335/scs.38.409_references_DOI_Krz9UmmJAECyVpmsB2urz70W0wZ

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  • Intracranial hemorrhage observed in the cases of cervical internal carotid artery occlusion associated with moyamoya disease-like vessels Reviewed

    Masanori Ishiguro, Yasutaka Kurokawa, Hachisaburo Takahashi

    Brain and Nerve   50 ( 12 )   1113 - 1118   1998

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  • Pathogenesis of hyponatremia following subarachnoid hemorrhage due to ruptured cerebral aneurysm Reviewed

    Y Kurokawa, T Uede, M Ishiguro, O Honda, O Honmou, T Kato, M Wanibuchi

    SURGICAL NEUROLOGY   46 ( 5 )   500 - 507   1996.11

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  • [Percutaneous transluminal angioplasty for cervical carotid artery stenosis].

    A Yamamura, H Oyama, F Matsuno, M Ishiguro, T Nakagawa, K Hashi

    No shinkei geka. Neurological surgery   23 ( 2 )   117 - 23   1995.2

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    Percutaneous transluminal angioplasty (PTA) was attempted in 16 patients (17 procedures) with cervical internal carotid artery (ICA) stenosis. Among the 16 patients, 14 were male and 2 were female aged from 44 to 76 years (average 63.4 years). One had cerebral infarction on the acute stage, and the other 15 were in the chronic stage. On CT scan and MRI, there were nine multiple lacunar infarctions and seven watershed infarctions. On angiographical findings, 13 had Rt.-ICA stenosis and 4 had Lt. ICA stenosis. Stenotic lesion existed beyond the level of the third cervical vertebral body in eleven cases, and so-called long segmental stenosis ranged from 3 to 5 cervical vertebral bodies in 3 cases. Before PTA, 14 patients underwent a balloon occlusion test for 3 to 20 minutes (average 9 minutes). Neurological symptoms of hemiparesis or sensory disturbance occurred in 3 patients during balloon inflation, but these disappeared completely after balloon deflation. It took from 1.5 to 2 hours (average 1.7 hours) to carry out PTA including the balloon occlusion test. All cases had satisfactory results with no morbidity or mortality. The mean stenosis ratio of pre-PTA, approximately 80% (55-93%), improved to that of 22% (0-50%) after PTA. Bradycardia and hypotension occurred transiently in 9 cases during and after PTA, but no symptoms remained by atropine sulfate and catecholamine infusion intravenously. In the following 1 to 26 months (mean 9.0 months) after PTA, 3 cases restenosed. The restenosis was recognized by MR angiography after 8 to 26 months (average 15.7 months) of PTA.(ABSTRACT TRUNCATED AT 250 WORDS)

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  • A case of suprasellar intradural chordoma Reviewed

    M. Wanibuchi, T. Uede, M. Ishiguro, K. Tatewaki, Y. Kurokawa, Y. Yoshida

    Neurological Surgery   22 ( 3 )   269 - 272   1994

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  • Cerebellopontine angle ganglioneuroblastoma. International journal

    T Sohma, H Tuchita, K Kitami, H Hotta, M Ishiguro, T Takeda

    Neuroradiology   34 ( 4 )   334 - 6   1992

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  • [Persistent primitive proatlantal intersegmental artery (PPPIA) presenting with cerebral infarction].

    M Ishiguro, T Sohma, H Tsuchita, K Kitami, H Hotta, Y Kurokawa

    No shinkei geka. Neurological surgery   19 ( 6 )   559 - 63   1991.6

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    A case of persistent primitive proatlantal intersegmental artery (PPPIA) is reported. A 65-year-old male with treated hypertension was admitted to our clinic complaining of dysarthria and hemiparesis of sudden onset two days after the ictus. CT revealed spotty low-density lesions in the left corona radiata and bilateral thalami with bilateral watershed infarction. MRI findings were also compatible with cerebral infarction. Left common carotid angiography demonstrated a large anastomosis between the external carotid artery and the vertebral artery at the proatlantal region. Neither of the vertebral arteries were visualized on digital subtraction aortography. All the blood circulation of the vertebro-basilar system was through this anastomotic artery (PPPIA). A flow study revealed hypoperfusion in the territory of the left middle cerebral artery on 133Xe SPECT. Bone window CT of cervical vertebrae revealed hypoplasia of the left transverse foramen in C2, C3, C4, C5, C6 vertebrae. This case is very suggestive of an anaplasia or hypoplasia of the vertebral arteries. The etiology of his left frontal infarction seemed to be a blood-stealing phenomenon of long standing, from the anterior to the posterior circulation through the PPPIA.

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  • Findings of magnetic resonance imaging in cerebral venous occlusion: difference from hemorrhagic infarction. International journal

    Y Kurokawa, T Sohma, H Tsuchita, K Kitami, S Suzuki, M Ishiguro

    Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society   14 ( 6 )   425 - 9   1990

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    A case of cerebral venous occlusion is reported. X-ray computed tomography showed a high-density lesion mimicking an intracerebral hemorrhage. In contrast, magnetic resonance images taken at the early clinical stage revealed a high-intensity lesion in both T1- and T2-weighted images. Follow-up magnetic resonance images at the chronic phase revealed that the intensity of this lesion had changed to low in the T1-weighted image, while still being high in the T2-weighted image. These findings suggest that the lesion might be due to venous congestion produced by cerebral venous occlusion rather than hemorrhage into the cerebral parenchyma.

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  • [Enlarging of intracranial hemorrhagic lesions and coagulative-fibrinolytic abnormalities in multiple-injury patients].

    Y Kurokawa, K Hashi, T Uede, S Matsumura, S Kashiwabara, M Ishiguro

    No shinkei geka. Neurological surgery   17 ( 4 )   335 - 41   1989.4

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    The clinical course of ten cases of head injury complicated with multiple systemic injuries were studied by comparing two groups divided according to the presence or absence of associated coagulative-fibrinolytic abnormality. All these cases had intracranial hemorrhagic lesions proven by the high density area in the initial CT scan. Five cases showed signs of disseminated intravascular coagulation (DIC) as evidenced by decreased counts of platelet, and/or elevated value of FDP at the time of admission. Four cases out of these five were in a state of hemorrhagic shock. All these five cases showed a subsequent enlargement of intracranial hematoma. Four cases died. Two of them, who had low initial Glasgow Coma Scale (G.C.S) died of uncontrollable increase of intracranial pressure. The other two, who had high initial G.C.S., died of acute renal failure and multiple organ failure. In contrast with these cases, five cases without signs of DIC intracranial hematomas did not enlarge in spite of the similar neurological conditions to the former group. In head injured patients with systemic injury, DIC frequently causes secondary hemorrhage in the intracranial lesions of minor severity.

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  • Clinical course of acute intracerebral hematoma which shows a fluid level presentation by X-ray CT Reviewed

    Y. Kurokawa, K. Hashi, T. Nakagawa, T. Uede, T. Shinya, M. Fujishige, M. Ishiguro, Y. Takamura

    Brain and Nerve   41 ( 8 )   771 - 776   1989

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MISC

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Research Projects

  • Influences of adenosine neuromodulation on hypothermic dysfunction and protection of brain

    Grant number：22K09165  2022.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • オキシヘモグロビンは神経活動を修飾する；脳スライスのシナプス活動と血管径の対比

    Grant number：18K08976  2018.4 - 2023.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    石黒 雅敬, 長峯 隆, 成松 英智

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    コロナ感染症の蔓延と家族の死による精神的ダメージを含めた個人的環境の不備より、研究を一時中断していた。

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  • 硫化水素の中枢神経系中毒機序と脳保護作用の解明

    Grant number：16K11411  2016.4 - 2023.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    成松 英智, 沢本 圭悟, 石黒 雅敬, 高橋 和伸, 高田 幸昌

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    令和3年度＜海馬CA1-錐体細胞における虚血脳損傷モデルに対する低濃度硫化物イオンの影響＞
    令和3年度も令和2年度に引き続き，海馬スライスCA1-錐体細胞虚血脳損傷モデルに対する硫化物イオン（S2-）の影響の検証を行った．細胞外電位同時多点記録法（MEA system）を用いて，樹状突起上のEPSPを反映するfield EPSP（以下，fEPSP）および神経細胞体上の活動電位を反映するpopulation spike（以下，PS）を同時記録し，シナプス伝達変化の指標として解析した．生体の硫化水素吸入による血漿中S2-を再現する目的で，人工髄液に硫化ナトリウム（以下，Na2S）を溶解させ灌流した．PSおよびfEPSPは低酸素無グルコース人工髄液（虚血モデル）の10分間灌流（1次性脳損傷モデル介入）により完全消失したが，その後の酸素化正常人工髄液によるwashoutで部分的に回復した（過年度データ）．この部分回復は，Na2S（100 mcM，10分間）の介入前および介入後投与により改善したが，同時介入では有意に変化しなかった．この成績は，すでに得られているグルタミン酸脳損傷におけるNa2S（100 mcM，10分間）の介入時の成績と類似した方向性のものであった．またNa2S（100 mcM，10分間）は単独ではPSおよびfEPSPに影響しなかった（初年度データ）．以上の成績は単独では無影響な低濃度のNa2Sは，ラット海馬スライス中枢神経系シナプス伝達において虚血モデル（低酸素+無グルコース）によるシナプス伝達障害（1次性脳損傷モデル）を投与時期依存性（前および後投与時に限定的）に改善させることを示す．

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  • Neural mechanisms of functional recovery of hindlimb locomotion after the spinal cord injury in quadrupeds

    Grant number：19500352  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    MATSUYAMA Kiyoji, ISHIGURO Masanori, SASAKI Takeshi

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • くも膜下出血後の脳血管攣縮でのR型カルシウムチャネルを標的とする新治療法の展開

    Grant number：18659425  2006 - 2007

    日本学術振興会  科学研究費助成事業  萌芽研究

    石黒 雅敬, 寶金 清博, 石黒 雅敬

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    Grant amount：\3300000 （ Direct Cost: \3300000 ）

    セロトニンは平滑筋を直接的に収縮および内皮を介して拡張させる。血管収縮には5-HT_<2A>と、5-HT_<1B>、5-HT_<1D>受容体が関係しているが、血管部位や動物の種により大きな差異がある。脳においてセロトニンは神経から拡散し、血管平滑筋には血液脳関門を介さずに到達し、脳血管や冠血管の血管攣縮あるいはその持続に影響すると考えられている。多くのセロトニン受容体サブタイプとそれぞれの作動薬および拮抗薬が見出されているが、脳血管系におけるセロトニンの意義には未解決な点が多い。今回セロトニン非存在下とセロトニン存在下の両者での塩酸サルポグレラートの血管反応を調べることを目的とした。
    Wister rat(n=8)とNew Zealand white rabbit(n=11)の上小脳動脈および後大脳動脈から直径100-200μm、長さ3mmの血管を剥離し、Vessel Chamber(CH/2/A)に設定し、顕微鏡下で、Pressure Servo Control and Pump: Model PS/200/Q, FC(Living System Instrument, Burlington, VT, USA)を用いて、60mmHgの血管内圧をかけて、myogenic tone(rat12.9%±1.6,rabbit13.4%±3.1)を得た血管の血管径を測定した。
    セロトニン受容体拮抗薬(5-HT2A blocker)である塩酸サルポグレラート(10^<-9>-10^<-3>M)に対する両者の反応に差を認めた。

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