Details of a Researcher - SOMEYA Masanori

Papers - SOMEYA Masanori

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The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer

Someya, M., Sakata, K-I, Matsumoto, Y., Kamdar, R. P., Kai, M., Toyota, M., Hareyama, M.

British Journal of Cancer ( NATURE PUBLISHING GROUP ) 104 ( 11 ) 1724 - 1729 2011 [Refereed]

BACKGROUND: Repair of various types of DNA damages is critical for genomic stability. DNA-dependent protein kinase (DNA-PK) has an important role in DNA double-strand break repair. We examined whether there may be a correlation between DNA-PK activity in peripheral blood lymphocytes (PBLs) and survival percentages in various cancer patients. We also investigated the changes of DNA-PK activity in PBLs after radiotherapy. METHODS: A total of 167 of untreated cancer patients participated in this study. Peripheral blood was collected, separated, and centrifuged. DNA-PK activity was measured by DNA-pull-down assay. Chromosomal aberrations were examined by cytogenetic methods. RESULTS: DNA-PK activity of PBLs in advanced cancer patients was significantly lower than that in early stage. The patients with lower DNA-PK activity in PBLs tended to have the lower disease-specific survivals and distant metastasis-free survivals than those with higher DNA-PK activity in advanced stages. There was also a tendency of inverse correlation between DNA-PK activity and excess fragments. The DNA-PK activity of PBLs in most patients decreased in response to radiation as the equivalent whole-body dose increased. CONCLUSION: Cancer patients in advanced stage, with lower DNA-PK activity of PBLs might have higher distant metastasis and exhibit poorer prognosis. Therefore, DNA-PK activity in PBLs could be used as a marker to predict the chromosomal instability and poorer prognosis. British Journal of Cancer (2011) 104, 1724-1729. doi:10.1038/bjc.2011.158 www.bjcancer.com Published online 10 May 2011 (C) 2011 Cancer Research UK

DOI PubMed

Gimeracil sensitizes cells to radiation via inhibition of homologous recombination.

Masaru Takagi, Koh-ichi Sakata, Masanori Someya, Hiroshi Tauchi, Kenta Iijima, Yoshihisa Matsumoto, Toshihiko Torigoe, Akari Takahashi, Masato Hareyama, Masakazu Fukushima

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 96 ( 2 ) 259 - 66 2010.08 [Refereed] [International journal]

BACKGROUND AND PURPOSE: 5-Chloro-2,4-dihydroxypyridine (Gimeracil) is a component of an oral fluoropyrimidine derivative S-1. Gimeracil is originally added to S-1 to yield prolonged 5-FU concentrations in tumor tissues by inhibiting dihydropyrimidine dehydrogenase, which degrades 5-FU. We found that Gimeracil by itself had the radiosensitizing effect. METHODS AND MATERIALS: We used various cell lines deficient in non-homologous end-joining (NHEJ) or homologous recombination (HR) as well as DLD-1 and HeLa in clonogenic assay. gamma-H2AX focus formation and SCneo assay was performed to examine the effects of Gimeracil on DNA double strand break (DSB) repair mechanisms. RESULTS: Results of gamma-H2AX focus assay indicated that Gimeracil inhibited DNA DSB repair. It did not sensitize cells deficient in HR but sensitized those deficient in NHEJ. In SCneo assay, Gimeracil reduced the frequency of neo-positive clones. Additionally, it sensitized the cells in S-phase more than in G0/G1. CONCLUSIONS: Gimeracil inhibits HR. Because HR plays key roles in the repair of DSBH caused by radiotherapy, Gimeracil may enhance the efficacy of radiotherapy through the suppression of HR-mediated DNA repair pathways.

DOI PubMed

Phase I Study of Oral S-1 and Concurrent Radiotherapy in Patients with Head and Neck Cancer

K. Nakata, M. Someya, M. Takagi, J. Hayashi, K. Miura, K. Sakata, M. Hareyama

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS ( ELSEVIER SCIENCE INC ) 78 ( 3 ) S450 - S451 2010 [Refereed]

The treatment outcome of patients undergoing breast-conserving therapy: the clinical role of postoperative radiotherapy.

Atsushi Oouchi, Koh-Ichi Sakata, Hideji Masuoka, Mitsuharu Tamakawa, Hisayasu Nagakura, Masanori Someya, Kensei Nakata, Kazuaki Asaishi, Minoru Okazaki, Yutaka Okazaki, Tousei Ohmura, Masato Hareyama, Masakazu Hori, Izuru Shimokawara, Akira Okazaki, Yoshiki Watanabe, Tsuyoshi Yamada, Tomokazu Yuyama, Taishi Satoh, Koichi Hirata

Breast cancer (Tokyo, Japan) 16 ( 1 ) 49 - 57 2009 [Refereed] [Domestic journal]

BACKGROUND: Treatment outcome was evaluated in patients who underwent breast-conserving therapy and tangential irradiation. After verifying background factors including systemic therapy, the clinical efficacy of postoperative irradiation was investigated. METHOD: There were 708 study subjects, all of whom had early breast cancer treated between 1992 and 2002. The median follow-up period was 83 months. After breast-conserving surgery, in patients with negative surgical margins, only tangential irradiation at 48 Gy/24 fr was performed. In contrast, in those with positive surgical margins, 10 Gy of radiation boost to the tumor bed with electrons was administered after tangential irradiation with 50 Gy/25 fr. Treatment outcome was analyzed using the Kaplan-Meier method and Cox's proportional hazards regression model. RESULTS: The disease-free survival and no-recurrence rates within the ipsilateral breast after 5 years were 93.4 and 97.2%, respectively. Risk factors for recurrence within the ipsilateral breast included younger age of patient, the number of positive lymph nodes, and no endocrine therapy. However, the surgical margin was not a risk factor. Risk factors for relapse outwith the ipsilateral breast included younger age, the number of positive lymph nodes, and recurrence within the ipsilateral breast. CONCLUSIONS: From our analysis of 708 Japanese women who received breast-conserving therapy, which can be regarded as a standard method in Japan, the treatment outcome was compatible with previous reports from other countries.

DOI PubMed

[Clinical application of altered fractionation theory].

Koh-ichi Sakata, Masanori Someya, Kensei Nakata, Masaru Takagi, Masato Hareyama

Gan to kagaku ryoho. Cancer & chemotherapy 35 ( 11 ) 1823 - 6 2008.11 [Refereed] [Domestic journal]

Altered fractionation schedules are based on two different concepts of radiobiology. One concept is that the radiation repair capability of cells in late responding tissues is higher than that of cells in acute responding tissues which include tumor tissues. Hyperfractionation utilizes this concept. The other concept is that accelerated repopulation of tumor cells occurs in a later period of radiation therapy. In order to overcome repopulation of tumor cells, accelerated hyperfractionation is proposed. These two concepts are independent and some fractionation methods include both concepts. Clinical results of altered fractionation schedules of radiation therapy could be predicted with a biological model (the linear quadratic model theory)for fractionated radiation. When this biological model is applied to tumors in which the tumor cell repopulation during radiotherapy period is negligible, the correction for tumor proliferation is required. Since the calculation of the biological effect dose with this model uses several assumptions, we should consider the biological effect dose as a crude approximation. Especially, in case of concomitant chemotherapy and altered fractionation, it is difficult to predict its results with a simple radiobiology model. The randomized trial is required to examine the significance of chemoradiotherapy using altered fractionation.

PubMed

Hyperfractionated accelerated radiotherapy for T1,2 glottic carcinoma. Consideration of time-dose factors.

Koh-ichi Sakata, Masanori Someya, Masakazu Hori, Kensei Nakata, Masaru Takagi, Masato Hareyama

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 184 ( 7 ) 364 - 9 2008.07 [Refereed] [International journal]

BACKGROUND AND PURPOSE: Hyperfractionated accelerated radiotherapy without a split (AF) has been performed to improve the local control probability of early glottic carcinomas since 1990 in the authors' institution. Here, they report their experience treating early glottic cancer patients with AF in a single institution who have a long follow-up period. PATIENTS AND METHODS: 131 T1 N0 M0 glottic cancers and 65 T2 N0 M0 glottic cancers were treated with conventional fractionation (CF) from 1984 to 1989 and with AF since 1990. CF consisted of five daily fractions of 2 Gy per week, to a total dose of 64 Gy. AF consisted of 1.72 Gy per fraction, two fractions per day, 5 days a week, to a total dose of 55 or 58.5 Gy. RESULTS: The 5-year local control probability for T1 tumors was 94% with 58.5 Gy and 87% with 55 Gy of AF, whereas it amounted to 80% with CF. For T2 tumors, it was 56% with 58.5 Gy and 68% with 55 Gy of AF, whereas it amounted to 64% with CF. The data of T2 should be evaluated with caution due to the small number of patients. Patients with AF had more severe mucosal reactions but no severe late reactions. CONCLUSION: AF significantly improved the local control rates for T1 glottic cancer.

DOI PubMed

Brachytherapy for oral tongue cancer: an analysis of treatment results with various biological markers.

Koh-ichi Sakata, Masanori Someya, Hisayasu Nagakura, Kensei Nakata, Atushi Oouchi, Masaru Takagi, Masato Hareyama

Japanese journal of clinical oncology 38 ( 6 ) 402 - 7 2008.06 [Refereed] [International journal]

OBJECTIVE: Low-dose-rate (LDR) brachytherapy is an effective treatment for tongue cancer. However, little is known about the biological mechanism underlying this therapy, characterized by delivery of continuous exposures of LDR irradiation. It is reported that lower microvessel density (MVD), lower Ki-67 index or higher expression of endogenous hypoxic markers such as carbonic CA IX and Glut-1 are related to the poor control of tumors treated with external irradiation. To elucidate the biological characteristics of LDR brachytherapy, we analyzed our results in cases of tongue cancer treated with LDR brachytherapy by using immunohistochemical stainings with antibodies against Ki-67 and MVD, Glut-1 and CA IX. METHODS: The prognostic value of Ki-67 index, MVD and the expression of CA IX and Glut-1 was assessed in 68 tongue cancers treated with LDR brachytherapy. The specimens were taken from tongue cancers before radiation therapy and immunohistochemical staining was performed. RESULTS: The local recurrence-free survival rates were significantly different between T1+T2 and T3 (P = 0.00067), but not between low and high Ki-67 indexes (P = 0.54), between low and high MVD (P = 0.071), low and high CA IX indexes (P = 0.062) or low and high Glut-1 indexes (P = 0.107). T stage, the size of the tumor was the only significant factor for local control in multivariate analyses (P = 0.0377). CONCLUSION: LDR could overcome the radioresistence of non-cycling and hypoxic cells; however, we cannot draw firm conclusions due to the limited number of patients.

DOI PubMed

Tissue oxygenation in a murine SCC VII tumor after X-ray irradiation as determined by EPR spectroscopy.

Hirotada Fujii, Koh-Ichi Sakata, Yoshihiro Katsumata, Rikiya Sato, Makoto Kinouchi, Masanori Someya, Shin-Ichiro Masunaga, Masato Hareyama, Harold M Swartz, Hiroshi Hirata

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 86 ( 3 ) 354 - 60 2008.03 [Refereed] [International journal]

PURPOSE: The goal of this study was to clarify the dynamics of oxygenation (partial pressure of oxygen, pO(2)) in SCC VII murine tumors in mice after X-ray irradiation. MATERIALS AND METHODS: Changes in pO(2) in tumors were measured by 1.2-GHz electron paramagnetic resonance (EPR) spectroscopy after they were exposed to various doses of irradiation. The pO(2) in tumors was followed for up to six days after irradiation at doses of 0, 5, 10, 15, and 20 Gy. Paramagnetic crystals were used as an oximetry probe and implanted into normal or tumor tissues in mice for prolonged periods. RESULTS: The pattern of tumor oxygen after a single dose of radiation with the 5-Gy dose was different from those with other doses (10, 15, and 20 Gy). After 5 Gy, pO(2) increased rapidly (P<0.01, Student's t test) and then returned to the level observed before irradiation by 12h (P<0.01). In contrast, after 10, 15, or 20 Gy, pO(2) increased rapidly by 6h after irradiation, continued to increase until at least 24h (P<0.01), and then gradually decreased. CONCLUSIONS: In tumors that received 5 Gy, post-irradiation increases in pO(2) at 4h after irradiation were detected by EPR oximetry (P<0.01) noninvasively.

PubMed

The enhanced expression of the matrix metalloproteinase 9 in nasal NK/T-cell lymphoma.

Koh-ichi Sakata, Masanori Someya, Mutsuko Omatsu, Hiroko Asanuma, Tadashi Hasegawa, Shingo Ichimiya, Masato Hareyama, Tetsuo Himi

BMC cancer 7 229 - 229 2007.12 [Refereed] [International journal]

BACKGROUND: Nasal NK/T cell lymphoma is an aggressive disease and has a poor prognosis. Nasal NK/T cell lymphoma is refractory to conventional chemotherapy and has strong tendency of widespread relapse or dissemination into distant sites. METHODS: We immunohistochemically studied nasal NK/T-cell lymphoma to elucidate the unique characteristics of nasal NK/T-cell lymphoma, such as its higher metastatic tendency and its vast necrosis which leads to destruction of the involved tissues. The expression of P-glycoprotein and MMP-9 was evaluated in the 20 patients with nasal NK/T-cell lymphoma and 25 with nasal non-NK/T-cell lymphoma and the relationship between expression of these proteins and clinical results were analyzed in this report. RESULTS: Overall 5-year survival rates for patients with nasal NK/T cell lymphoma, and nasal non-NK/T cell lymphoma were 51%, and 84%. Distant involvement free 5-year survival rates for patients with nasal NK/T cell lymphoma, and nasal non-NK/T cell lymphoma were 53%, and 79%. Overall positivity for P-glycoprotein was observed in 10 of 19 patients with NTL and in 13 of 23 patients with non-NTL. When the overall survival rate was compared between patients with P-glycoprotein positive and negative, there was no difference between them. Sixteen of the 19 patients with nasal NK/T cell lymphoma expressed MMP-9. In contrast, only 8 of the 22 patients with nasal non-NK/T cell lymphoma expressed MMP-9. Distant involvement free 5-year survival rates for patients with MMP-9 negative, and MMP-9 positive were 92%, and 61%, respectively. The difference was statistically significant (p = 0.027). CONCLUSION: Positive immunoreactivity for P-glycoprotein was not an independent prognostic factor in nasal NK/T-cell lymphomas, which stresses the importance of exploring other mechanisms of drug resistance. The strong expression of MMP-9 is uniquely characteristic of nasal NK/T cell lymphoma and may contribute to its strong tendency to disseminatate and the extensive necrosis which is always seen. However, our results are based on univariate comparisons, and as such, should be viewed with some caution.

PubMed

Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity.

Koh-Ichi Sakata, Masanori Someya, Yoshihisa Matsumoto, Masato Hareyama

Radiation medicine 25 ( 9 ) 433 - 8 2007.11 [Refereed] [Domestic journal]

Traditional radiobiology has aimed at elucidating the mechanism of radiosensitivity of cancer cells and normal cells. Because the mechanism of DNA double-strand break (DSB) repair, which is inherently important to radiosensitivity, was unknown, it has been difficult to obtain results applicable to clinical radiotherapy from traditional radiobiology research. Today, however, the molecular mechanism of DNA DSB repair has been elucidated because of the rapid advances in molecular biology. In DNA DSB repair, at least two major repair mechanisms, homologous recombination and nonhomologous end joining (NHEJ) have been reported. In the NHEJ pathway, DSBs are directly, or after processing of the DNA ends, rejoined at an appropriate chromosomal end. DNA-dependent protein kinase (DNA-PK) plays an important role in DNA DSB repair by NHEJ. We have investigated how the ability of repair of DNA DSB influences cancer susceptibility and the radiosensitivity of tumors and normal tissues by focusing on the activity of DNA-PK. In the near future, research on DNA DSB repair mechanism will be able to be applied to research on carcinogenesis, prediction of radiosensitivity of tumors and normal cells, and sensitization of tumor cells.

PubMed

The efficacy and usefulness of problem based learning in undergraduate medical school education of radiation oncology

Minako Uchino, Tomoko Itazawa, Masanori Someya, Satoaki Nakamura

Journal of JASTRO 19 ( 3 ) 139 - 145 2007.09

The Japanese Association for Therapeutic Radiation Oncology (JASTRO) holds a seminar for medical students every summer, which has developed into a joint program with a session addressing radiation treatment planning. To clarify this topic for medical students, we have incorporated Problem Based Learning skills into the session. Not only has the students' comprehension improved but the instructors have also found this teaching experience valuable and productive in advancing their own clinical skills. Our experience suggests that the application of this Problem Based Learning session for radiation treatment planning in undergraduate medical school education has proven to be effective.

cDNA analysis of gene expression associated with DNA-dependent protein kinase activity.

Koh-ichi Sakata, Hiroyuki Yamamoto, Yoshihisa Matsumoto, Masanori Someya, Masato Hareyama

International journal of oncology 30 ( 2 ) 413 - 20 2007.02 [Refereed] [International journal]

DNA-dependent protein kinase (DNA-PK) is thought to play a pivotal role in DNA double-strand break repair. We recently demonstrated the association of DNA-PK activity in peripheral blood lymphocytes (PBL) with the incidence of chromosomal aberrations and the risk of cancer. In this study, we applied cDNA array technology to find the expression of genes which are associated with DNA-PK activity in PBLs with various levels of DNA-PK activity. Most genes correlated with DNA-PK activity involved cell cycle regulation. Moreover, the transcription factor E2F1, which plays an important role in cell cycle progression, exhibited strong correlation with the DNA-PK activity and Rbp130, which is considered a negative regulator of E2F, showed inverse correlation with DNA-PK activity. In silico promoter analyses showed the presence of at least one E2F binding site in the promoter regions of Ku70, Ku86, DNA-PKcs and genes associated with DNA-PK activity. In order to examine the relationship among the E2F1 expression, the expression of genes related with DNA-PK activity, and DNA-PK activity, we activated PMLs by PHA to progress the cell cycle. After PHA activation of PML, the expression of E2F1 and DNA-PK activity increased. The expression of most genes in PHA-stimulated PBLs had a similar relationship with DNA-PK activity to that without PHA stimulation. These results indicate that the E2F transcription factor may regulate the concerted expression of genes related with DNA-PK activity.

PubMed

The application of theory of altered fractionation on clinics

Koh-ichi Sakata, Masanori Someya, Kensei Nakata, Masaru Takagi, Kazuo Kojima, Masato Hareyama

Toukeibu Gan 33 ( 3 ) 280 - 282 2007

Altered fractionation schedules are based on two different concepts of radiobiology. One concept is that the radiation repair capability of cells in late responding tissues is higher than that of cells in acute responding tissues which include tumor tissues. Hyperfractionation utilizes this concept. The other concept is that accelerated repopulation of tumor cells occurs in a later period of radiation therapy. In order to overcome repopulation of tumor cells, the technique of accelerated hyperfractionation has been developed. Clinical results of altered fractionation schedules of radiation therapy could be predicted with the linear quadratic model thery for fractionated radiation. However, in the case of concomitant chemotheraoy and altered fractionation, it is difficult to predict its results with a simple radiobiology model. Randomized trias are required to examine the significance of chemoradiotherapy using altered fractionation. © 2007, Japan Society for Head and Neck Cancer. All rights reserved.

DOI

A clinical study of hypoxia using endogenous hypoxic markers and polarographic oxygen electrodes.

Koh-ichi Sakata, Masanori Someya, Hisayasu Nagakura, Kensei Nakata, Atushi Oouchi, Masato Hareyama, Masaaki Satoh

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 182 ( 9 ) 511 - 7 2006.09 [Refereed] [International journal]

PURPOSE: To examine various kinds of endogenous hypoxia markers' expression in the tissues of uterine cervix cancer and to elucidate the characteristics and pitfalls when they are used as a hypoxia marker, by comparing these expressions with tumor oxygen partial pressure (pO2) values. PATIENTS AND METHODS: Assessment of pO2 using polarographic oxygen electrodes was performed in 69 patients with cervix carcinomas. Biopsies were taken from the region of electrode measurements. Expression of endogenous hypoxic markers in biopsy specimens such as vascular endothelial growth factor, glucose transporter-1 (GLUT-1), involucrin, and osteopontin was detected by immunohistochemistry. A double immunolabeling technique with GLUT-1 and MIB-1 as a marker of proliferation was also performed. RESULTS: There was no significant correlation between expression of endogenous hypoxic markers and pO2. The only significant association seen was between the fraction of necrosis and pO2. A significant but weak correlation was found among expression of endogenous hypoxic markers. The levels of necrosis were related negatively with levels of expression of endogenous hypoxic markers. The double immunolabeling technique with GLUT-1 and MIB-1 indicated that there were about 20% MIB-1-positive tumor cells without GLUT-1 expression in tissues adjacent to areas of necrosis. CONCLUSION: The existence of necrosis affected the expression of endogenous hypoxic markers. Some hypoxic tumor cells without expressions of hypoxia markers can maintain clonogenicity and influence the treatment results. The combined use of hypoxic markers is recommended because their expression is influenced by factors other than hypoxia.

PubMed

The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.

Masanori Someya, Koh-ichi Sakata, Yoshihisa Matsumoto, Hiroyuki Yamamoto, Manami Monobe, Hideyuki Ikeda, Koichi Ando, Yoshio Hosoi, Norio Suzuki, Masato Hareyama

Carcinogenesis 27 ( 1 ) 117 - 22 2006.01 [Refereed] [International journal]

The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteers were enrolled. Peripheral blood was collected, separated and centrifuged; DNA-PK activity was measured by DNA-pull-down assay. The expressions of DNA-PKcs, Ku70 and Ku86 were examined by RT-PCR assay and western blotting. Chromosomal aberrations were examined by cytogenetic methods. DNA-PK activities of peripheral blood lymphocytes (PBL) in patients with uterine cervix or breast cancer were significantly lower than those in normal volunteers. Age and smoking had no association with DNA-PK activity, whereas DNA-PK activity and the expression of Ku70, Ku86 and DNA-PKcs in RT-PCR were interrelated. A similar tendency was seen in western blot assay but less clear than in RT-PCR. Therefore, the association between DNA-PK activity and expression of DNA-PK in protein level could not be concluded. The frequency of chromosome aberration, such as dicentric chromosomes and excess fragment increased as the DNA-PK activity decreased. In conclusion, DNA-PK activity is associated with chromosomal instability. DNA-PK activity in PBL is associated with risk of breast and uterine cervix cancer. DNA-PK activity in PBL can be used to select individuals for whom an examination should be performed because of their increased susceptibility to breast and uterine cervix cancer.

PubMed

Analysis of local control in patients with non-Hodgkin's lymphoma according to the WHO classification.

Koh-Ichi Sakata, Masaaki Satoh, Masanori Someya, Hisayasu Nagakura, Atushi Oouchi, Kensei Nakata, Katsuhisa Kogawa, Kazumitsu Koito, Masato Hareyama, Tetsuo Himi

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 181 ( 6 ) 385 - 91 2005.06 [Refereed] [International journal]

PURPOSE: To analyze the influence of radiotherapy doses, chemotherapy doses, and clinical parameters on in-field disease control to assess the optimal radiation doses for treatment of non-Hodgkin's lymphoma according to the newly proposed WHO classification. PATIENTS AND METHODS: Subjects consisted of 35 extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type, 75 diffuse large B-cell lymphomas (DLBCL), 14 follicular lymphomas, 17 extranodal natural killer (NK)/T-cell lymphomas, nasal type, eight unclassified peripheral T-cell lymphomas, four anaplastic large-cell lymphomas, T/null cell type, and five others. 59 patients received radiotherapy alone. 98 patients received CHOP, modified CHOP, or more intensive chemotherapy, and six patients were treated with other combination. RESULTS: No patients with MALT lymphoma had in-field local recurrence. There were no recurrences in DLBCL patients who received chemotherapy in which the doses of adriamycin were > 200 mg/m(2), nor in DLBCL patients who were treated with > 45 Gy. Only nine of 15 patients with T-cell lymphoma treated with < or = 50 Gy and three of five patients treated with > 50 Gy had local control. The dose of adriamycin had no influence on local control of T-cell lymphoma. CONCLUSION: T/NK-cell lymphomas were more radioresistant than B-cell lymphomas. The prognosis for peripheral T/NK-cell lymphomas is poor even when treated by irradiation combined with chemotherapy.

PubMed

Three cases of diffuse large B-cell lymphoma of the mandible treated with radiotherapy and chemotherapy.

Masanori Someya, Koh-Ichi Sakata, Hisayasu Nagakura, Katsuya Itou, Kensei Nakata, Atsushi Oouchi, Masaaki Satoh, Masato Hareyama

Radiation medicine 23 ( 4 ) 296 - 302 2005.06 [Refereed] [Domestic journal]

CASE REPORT: We report three cases of diffuse large B-cell lymphoma of the mandible and a review of the literature. All 3 of our patients had stage I AE disease and had complete remission for more than 2 years after 42-46 Gy of irradiation to the primary tumor with regional lymph nodes and 3 courses of chemotherapy consisting of cyclophosphamide, adriamycin, vincristine, and predonisolone (CHOP). Literature analysis, although biased toward published data, indicated that the 3-year disease-specific survival rates for non-Hodgkin's lymphoma (NHL) of the mandible were 90.5% and 47.6% for stages I and II, respectively. The treatment results for NHL of the mandible may be similar to general primary bone NHL and to other extranodal NHL's. CONCLUSION: Radiotherapy alone is not sufficient for tumor control for stage I+II, disease, and combination chemotherapy may be needed.

PubMed

Preliminary clinical results of conformal radiation therapy for prostate cancer

Atsushi Oouchi, T. Nakata, K. Aratani, M. Hori, T. Tsuchimoto, M. Someya, H. Nagakura, K. Sakata, M. Hareyama, N. Masumori, Y. Tsukamoto

Japanese Journal of Clinical Radiology 50 ( 5 ) 633 - 637 2005

We evaluated clinical results of delivered conformal radiation therapy (70 to 72Gy) in our hospital to 52 patients with T1-T3 prostate cancer. The median follow-up period is 23 months. The 5-year PSA relapse free survival rates (b-NED) were calculated according to T-stage. Gleason score, serum PSA and prognostic risk group. GU and GI morbidities were also examined. By the affection of adjuvant hormonal therapy, we were not able to find any statistical significant factor of local control. However, it is suspected that the conformal radiation therapy is useful for favorable risk group and that the radiation dose escalation or the combination of endocrine therapy will be required for improving b-NED of the other risk groups.

Expression of matrix metalloproteinase 9 is a prognostic factor in patients with non-Hodgkin lymphoma.

Koh-ichi Sakata, Masaaki Satoh, Masanori Someya, Hiroko Asanuma, Hisayasu Nagakura, Atushi Oouchi, Kensei Nakata, Katsuhisa Kogawa, Kazumitsu Koito, Masato Hareyama, Tetsuo Himi

Cancer 100 ( 2 ) 356 - 65 2004.01 [Refereed] [International journal]

BACKGROUND: Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of tumors that vary with regard to their biologic aggressiveness and clinical course. In in vitro studies, matrix metalloproteinase 9 (MMP9) was reportedly expressed by human NHL cells and elevated levels of MMP9 have been observed in a subset of patients with high-grade NHL. METHODS: The expression of MMP2 and MMP9 was evaluated in 158 patients with NHL and the relation between the expression of these proteins and clinicopathologic factors was analyzed. All but 1 patient had received radiation therapy and 92 patients also were treated with intensive combination chemotherapy. RESULTS: Nearly all the patients with extranodal natural killer NK/T-cell lymphoma nasal type and anaplastic large cell lymphoma, T-cell/null cell type expressed MMP9. In contrast, only a small fraction of the patients with mucosa-associated lymphoid tissue (MALT) lymphomas and follicular lymphomas expressed MMP9. Approximately 50% of the diffuse large B-cell lymphoma (DLBCL) cases expressed MMP9. The expression of MMP2 was noted in some of the patients with DLBCL and nasal NK/T-cell lymphoma. The overall survival rates of patients who expressed MMP9 were significantly lower than that of those who did not. Such a correlation was not demonstrated in MMP2 expression. When MMP9 expression was analyzed in DLBLC patients, the overall survival rates of patients who expressed MMP9 were significantly lower than those who did not express MMP9. Chemotherapy was associated with better overall survival in DLBCL patients who expressed MMP9. Overall survival rates of T-cell/NK-cell lymphoma patients who expressed MMP9 appeared to be lower than that in those who did not express MMP9. However, chemotherapy was not found to improve overall survival in patients who expressed MMP9. CONCLUSIONS: MMP9 expression was observed in patients with aggressive NHL and was characterized by poor overall survival.

PubMed

THE CAREER PATHS OF THE PARTICIPANTS IN A RADIATION ONCOLOGY SEMINAR FOR MEDICAL DOCTOR CANDIDATES IN 1997

IMAGUMBAI Toshiyuki, UCHINO Minako, ITAZAWA Tomoko, SOMEYA Masanori, BITO Seiji

J Jpn Soc Ther Radiol Oncol ( Japanese Society for Therapeutic Radiology and Oncology ) 16 ( 4 ) 225 - 229 2004

Since 1995, the Japanese Society for Therapeutic Radiology and Oncology (JASTRO) has held a teaching seminar for medical doctor candidates. In 1997, thirty-three students participated in the seminar. After graduation, eighteen (18/33) of the participants became radiologists and twelve of them (12/18) majored in radiation oncology. These results imply that the seminar might have an impact on their career paths. Hence, we propose that the seminar can have an influence upon the career decision of medical students, and it could yield a breakthrough to overcome in the shortage of radiation oncologists in Japan.

DOI CiNii J-GLOBAL

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Papers - SOMEYA Masanori