Misc - IYAMA Satoshi

Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome

Seitaro Terakura, Tetsuya Nishida, Masashi Sawa, Tomonori Kato, Kotaro Miyao, Yukiyasu Ozawa, Tatsunori Goto, Akio Kohno, Kazutaka Ozeki, Yasushi Onishi, Noriko Fukuhara, Nobuharu Fujii, Hisayuki Yokoyama, Masanobu Kasai, Hiroatsu Iida, Nobuhiro Kanemura, Tomoyuki Endo, Hiroatsu Ago, Makoto Onizuka, Satoshi Iyama, Yuichiro Nawa, Mika Nakamae, Yasuyuki Nagata, Shingo Kurahashi, Yasuo Tomiya, Atsumi Yanagisawa, Ritsuro Suzuki, Yachiyo Kuwatsuka, Yoshiko Atsuta, Koichi Miyamura, Makoto Murata

Bone Marrow Transplantation ( Springer Science and Business Media LLC )  55 ( 7 ) 1399 - 1409  2020.07  [Refereed]  [International journal]

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A prospectively registered observational study was conducted to assess the significance of allogeneic hematopoietic stem cell transplantation from highly HLA-matched unrelated donors (UD) and cord blood (CB) on outcomes in adult acute leukemia (AL) and myelodysplastic syndrome (MDS). Between 2007 and 2015, 231 transplant-eligible patients were registered for a phase 2 study of alternative donor transplantation. After registration, a sufficient time period was given to find appropriate UD. Patients received CB transplantation (CBT) if an appropriate UD was unavailable. In total, 119 patients received CBT (106 AL and 13 MDS) and 91 patients received UD transplantation (UDT) (86 AL and 5 MDS). The median age was 39 years in both groups. The primary objective was overall survival (OS); secondary objectives included cumulative incidences of non-relapse mortality (NRM) and relapse, and disease-free survival. Diagnosis, disease status at transplantation, refined disease risk index, and hematopoietic cell transplant-specific comorbidity index did not differ between UDT and CBT. In multivariate analyses, graft source was not a significant risk factor for all objectives. In adjusted analyses, UDT and CBT showed similar OS, NRM, and relapse in this prospective study. CB can be a comparable alternative stem cell source to UD by achieving a timely transplant.

DOI PubMed

Prospective Evaluation of Alternative Donor from Unrelated Volunteer Donor and Cord Blood in Adult Acute Leukemia and Myelodysplastic Syndrome: No Difference between Unrelated Donor and Cord Blood

Seitaro Terakura, Tetsuya Nishida, Masashi Sawa, Tomonori Kato, Kotaro Miyao, Yukiyasu Ozawa, Tatsunori Goto, Akio Kohno, Kazutaka Ozeki, Yasushi Onishi, Noriko Fukuhara, Nobuharu Fujii, Hisayuki Yokoyama, Masanobu Kasai, Hiroatsu Iida, Nobuhiro Kanemura, Tomoyuki Endo, Hiroatsu Ago, Makoto Onizuka, Satoshi Iyama, Yuichiro Nawa, Mika Nakamae, Yasuyuki Nagata, Shingo Kurahashi, Yasuo Tomiya, Atsumi Yanagisawa, Ritsuro Suzuki, Yachiyo Kuwatsuka, Yoshiko Atsuta, Koichi Miyamura, Makoto Murata

BLOOD ( AMER SOC HEMATOLOGY )  134  2019.11

Research paper, summary (international conference)  

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DOI

【悪性黒色腫】 播種性骨髄癌腫症を呈した悪性黒色腫の1例

澤田 匡秀, 澄川 靖之, 佐藤 さゆり, 菅 裕司, 加藤 潤史, 肥田 時征, 山下 利春, 橋本 亜香利, 井山 諭

皮膚科の臨床 ( 金原出版(株) )  59 ( 13 ) 1963 - 1966  2017.12

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79歳女。約2年前に左第4趾に黒色結節を自覚し、徐々に増大した。全切除生検を施行し、病理組織学的所見より悪性黒色腫と診断した。全身検索で他臓器転移を認めず、足趾離断術とセンチネルリンパ節生検を施行した。摘出した4個のリンパ節全てに転移を認めたため、鼠径、外腸骨、閉鎖リンパ節郭清を追加した。郭清したリンパ節に転移はなかった。pT3bN3M0 Stage IIICと診断し、術後化学療法としてDAV-Feron療法を計6クール施行した。以後はフェロン局注療法を継続していたが、術後約3年3ヵ月で突然強い腰痛が出現した。各種画像所見、臨床検査所見、骨髄生検の病理組織所見より、悪性黒色腫による播種性骨髄癌腫症とした。化学療法を施行するも改善なく、入院から19日後に永眠された。

DOI

P53-RESTORING SMALL MOLECULE CP-31398 INDUCES APOPTOSIS VIA INDUCTION OF REACTIVE OXIDATIVE SPECIES IN HUMAN MULTIPLE MYELOMA

Y. Arihara, K. Takada, Y. Kawano, N. Hayasaka, H. Nakamura, S. Kikuchi, Y. Kamihara, K. Murase, H. Ikeda, S. Iyama, T. Sato, K. Miyanishi, M. Kobune, J. Kato

HAEMATOLOGICA ( FERRATA STORTI FOUNDATION )  102   498 - 498  2017.06

Research paper, summary (international conference)  

CD34/EPO-R Double Positive MDS Cells Produce Erythroferrone in Response to Erythropoietin

Shogo Miura, Masayoshi Kobune, Soushi Ibata, Masahiro Yoshida, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Wataru Jomen, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  128 ( 22 )  2016.12

Research paper, summary (international conference)  

Next Generation Sequencing of CD138+Myeloma Cells Could Predict Response Rate and Appropriate Therapy at Diagnosis

Hiroshi Ikeda, Yasushi Sasaki, Soushi Ibata, Masahiro Yoshida, Ayumi Tatekoshi, Satoshi Iyama, Kazuyuki Murase, Kohichi Takada, Shohei Kikuchi, Tsutomu Sato, Masayoshi Kobune, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  128 ( 22 )  2016.12

Research paper, summary (international conference)  

Extracellular Vesicle microRNAs from Acute Myeloid Leukemia Are Involved in the Regulation of Adherence Junction in Bone Marrow Microenvironment.

Masahiro Yoshida, Masayoshi Kobune, Shogo Miura, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  128 ( 22 )  2016.12

Research paper, summary (international conference)  

Abnormal intracellular response induced by iron overload

小船 雅義, 井山 諭, 堀口 拓人

血液内科 = Hematology ( 科学評論社 )  73 ( 4 ) 503 - 508  2016.10

CiNii

A PHASE 2 TRIAL OF SMALL-DOSE BORTEZOMIB, LENALIDOMIDE, AND DEXAMETHASONE (SVRD) AS CONSOLIDATION/MAINTENANCE THERAPY IN PATIENTS WITH MULTIPLE MYELOMA

T. Sato, H. Kuroda, Y. Nagamachi, S. Iyama, A. Fujimi, Y. Kamihara, Y. Konuma, M. Yoshida, S. Ibata, A. Tatekoshi, A. Hashimoto, H. Horiguchi, K. Ono, K. Murase, K. Takada, K. Miyanishi, M. Kobune, Y. Hirayama, J. Kato

HAEMATOLOGICA ( FERRATA STORTI FOUNDATION )  101   792 - 793  2016.06

Research paper, summary (international conference)  

DEFERASIROX INDUCES APOPTOSIS THROUGH INHIBITION OF ONCOGENIC PYK2/BETA-CATENIN SIGNALING IN MULTIPLE MYELOMA CELLS

K. Takada, Y. Kamihara, T. Sato, Y. Kawano, K. Murase, Y. Arihara, S. Kikuchi, N. Hayasaka, M. Usami, S. Iyama, K. Miyanishi, M. Kobune, J. Kato

HAEMATOLOGICA ( FERRATA STORTI FOUNDATION )  101   78 - 79  2016.06

Research paper, summary (international conference)  

多発性骨髄腫における鉄代謝異常および鉄キレート剤による抗腫瘍効果の解析

高田 弘一, 神原 悠輔, 佐藤 勉, 河野 豊, 井山 諭, 村瀬 和幸, 菊地 尚平, 堀口 拓人, 橋本 亜香利, 舘越 鮎美, 瀧本 理修, 小船 雅義, 加藤 淳二

International Journal of Myeloma ( 日本骨髄腫学会 )  5 ( 2 ) 100 - 100  2015.05

A phase I/II study of definitive chemoradiotherapy with docetaxel, nedaplatin, and 5-fluorouracil (DNF-R) for advanced esophageal cancer

Yasushi Sato, Hiroyuki Ohnuma, Masahiro Hirakawa, Yutaka Okagawa, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Tamotsu Sagawa, Masakazu Hori, Masanori Someya, Koh-ichi Sakata, Tetsuji Takayama, Junji Kato

JOURNAL OF CLINICAL ONCOLOGY ( AMER SOC CLINICAL ONCOLOGY )  33 ( 3 )  2015.01

Research paper, summary (international conference)  

Exosomes Derived from AML/MDS Cells Is Involved in Stromal Dysfunction and Bone Marrow Failure

Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Wataru Jomen, Kazuyuki Murase, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Yusuke Kamihara, Koji Miyanishi, Yasushi Sato, Tsuyoshi Hayashi, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  124 ( 21 )  2014.12

Research paper, summary (international conference)  

EFFICACY OF NEOADJUVANT CHEMOTHERAPY WITH DOXORUBICIN PLUS IFOSFAMIDE FOR INTERMEDIATE TO HIGH-RISK SOFT TISSUE

Kohichi Takada, Shogo Miura, Rishu Takimoto, Yusuke Kamihara, Satoshi Iyama, Yutaka Okagawa, Yasushi Sato, Toshihiko Yamashita, Tadashi Hasegawa, Junji Kato

ANNALS OF ONCOLOGY ( OXFORD UNIV PRESS )  25  2014.10

Research paper, summary (international conference)  

RADIATION-INDUCED LEIOMYOSARCOMA IN PROSTATE AFTER BRACHYTHERAPY FOR PROSTATIC ADENOCARCINOMA

Hiroto Horiguchi, Kohichi Takada, Rishu Takimoto, Satoshi Iyama, Tsutomu Sato, Yasuo Hirayama, Toshifumi Hoki, Naoya Masumori, Tadashi Hasegawa, Junji Kato

ANNALS OF ONCOLOGY ( OXFORD UNIV PRESS )  25  2014.10

Research paper, summary (international conference)  

28-P4AM-030 骨髄異形成症候群治療薬アザシチジンの制吐療法の評価(がん薬物療法(制吐支持療法),一般演題(ポスター),新時代を拓く医療薬学フロンティア)

中村 勝之, 野田 師正, 沖田 憲司, 高田 弘一, 井山 諭, 佐藤 勉, 瀧本 理修, 小船 雅義, 加藤 淳二, 池田 博, 林 敏昭, 石田 禎夫, 篠村 恭久, 中田 浩雅, 宮本 篤

日本医療薬学会年会講演要旨集 ( 日本医療薬学会 )  24   380 - 380  2014.08

CiNii

CD19-TARGETING LIPOSOMES CONTAINING RAPAMYCIN INDUCE AUTOPHAGIC CELL DEATH IN BURKITT'S LYMPHOMA CELLS

T. Sato, K. Ono, S. Iyama, A. Tatekoshi, A. Hashimoto, Y. Kamihara, H. Horiguchi, K. Takada, T. Hayashi, K. Miyanishi, Y. Sato, R. Takimoto, M. Kobune, J. Kato

HAEMATOLOGICA ( FERRATA STORTI FOUNDATION )  99   135 - 135  2014.06

Research paper, summary (international conference)  

DISTURBANCE OF EPIGENETIC STATUS IN STROMAL CELLS COULD BE INDUCED BY INTERACTION WITH MDS/AML-INITIATING CELLS

M. Kobune, H. Horiguchi, S. Kikuchi, K. Takada, S. Iyama, T. Sato, A. Hashimoto, A. Tatekoshi, T. Hayashi, K. Miyanishi, Y. Sato, R. Takimoto, J. Kato

HAEMATOLOGICA ( FERRATA STORTI FOUNDATION )  99   84 - 84  2014.06

Research paper, summary (international conference)  

Markers of bone metabolism in multiple myeloma patients switched from zoledronic acid to denosumab

TATEKOSHI Ayumi, SATO Tsutomu, IBATA Soushi, HASHIMOTO Akari, KAMIHARA Yusuke, HORIGUCHI Hiroto, ONO Kaoru, TAKADA Kohichi, IYAMA Satoshi, TAKIMOTO Rishu, KOBUNE Masayoshi, KATO Junji

Rinsho Ketsueki ( The Japanese Society of Hematology )  55 ( 11 ) 2271 - 2276  2014

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To date, intravenous drip infusion of zoledronic acid (ZA) has mainly been used for the treatment and prevention of skeletal-related events (SRE) in patients with multiple myeloma (MM). Recently, denosumab, a fully humanized monoclonal antibody against receptor activator of nuclear factor-κB ligand (RANKL), has also become available for the same purpose, but little is known about the impact of switching from ZA to denosumab. Herein, we present a retrospective study on bone metabolic markers in 10 MM patients initially treated with ZA and then switched to denosumab. Consequently, the levels of bone resorption markers, tartrate-resistant acid phosphatase 5b (TRACP-5b) and serum type-I collagen crosslinked N-telopeptide (sNTX), significantly decreased after denosumab treatment, while the levels of bone formation markers, osteocalcin (OC) and bone-specific alkaline phosphatase (BAP), showed no apparent changes. No patient developed severe hypocalcemia with denosumab treatment. In one patient not given chemotherapy, the M-protein level increased after switching from ZA to denosumab and plateaued when ZA was restarted. Based on this finding, we anticipate that switching from ZA to denosumab would exert a stronger suppressive effect on osteoclasts, but the anti-myeloma activity of ZA must be taken into consideration.

DOI CiNii

土-P3-462 多発性骨髄腫に対するレナリドミド療法の有害事象の解析と薬剤管理指導(3)(がん薬物療法(その他),ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

中村 勝之, 野田 師正, 高田 弘一, 井山 諭, 佐藤 勉, 瀧本 理修, 小船 雅義, 加藤 淳二, 安井 寛, 池田 博, 林 敏昭, 石田 禎夫, 篠村 恭久, 中田 浩雅, 宮本 篤

日本医療薬学会年会講演要旨集 ( 日本医療薬学会 )  23   328 - 328  2013.08

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北海道における成人T細胞性白血病/リンパ腫に対する全同種造血幹細胞移植成績

重松明男, 重松明男, 田中淳司, 小林直樹, 安井寛, 進藤基博, 柿木康孝, 幸田久平, 井山諭, 黒田裕行, 堤豊, 橋野聡, 今村雅寛, 豊嶋崇徳

日本造血細胞移植学会総会プログラム・抄録集   35th   190  2013.02

J-GLOBAL

Role of Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia in an HTLV-1 Non-Endemic Area of Japan.

Akio Shigematsu, Junji Tanaka, Naoki Kobayashi, Hiroshi Yasui, Motohiro Shindo, Yasutaka Kakinoki, Kakinoki Yasutaka, Satoshi Iyama, Kuroda HIroyuki, Tsutsumi Yutaka, Satoshi Hashino, Masahiro Imamura, Takanori Teshima

BLOOD ( AMER SOC HEMATOLOGY )  120 ( 21 )  2012.11

Research paper, summary (international conference)  

DOI

P1-272 多発性骨髄腫に対するレナリドミド療法の有害事象の解析と薬剤管理指導(2)(がん薬物療法(他の副作用対策),ポスター,一般演題,岐路に立つ医療〜千年紀の目覚め〜よみがえれ!ニッポン!薬の改革は我らが手で!)

中村 勝之, 野田 師正, 林 敏昭, 石田 禎夫, 篠村 恭久, 高田 弘一, 井山 諭, 加藤 淳二, 中田 浩雅, 宮本 篤

日本医療薬学会年会講演要旨集 ( 日本医療薬学会 )  22   312 - 312  2012.10

CiNii

SUCCESSFUL INDUCTION AND LONG-TERM FOLLOW-UP AFTER FLAG-MG THERAPY: CHEMOTHERAPY FOLLOWED BY GEMTUZUMAB OZOGAMICIN IN SIX PATIENTS WITH RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA

Y. Hirayama, T. Terui, K. Koike, T. Kusakabe, T. Ishihara, K. Ishitani, S. Iyama, T. Sato, R. Takimoto, M. Kobune, J. Kato

ANNALS OF ONCOLOGY ( OXFORD UNIV PRESS )  23   165 - 166  2012.10

Research paper, summary (international conference)  

RETROSPECTIVE ANALYSIS OF IFOSFAMIDE ENCEPHALOPATHY IN PATIENTS WITH BONE AND SOFT TISSUE SARCOMAS

K. Takada, R. Takimoto, T. Yoshinaga, S. Iyama, K. Ono, K. Murase, T. Sato, K. Miyanishi, Y. Sato, M. Kobune, T. Soma, S. Nagoya, T. Yamashita, A. Watanabe, J. Kato

ANNALS OF ONCOLOGY ( OXFORD UNIV PRESS )  23   130 - 130  2012.10

Research paper, summary (international conference)  

CASE REPORt : Effective Treatment with both Chemo-radiotherapy and Donor Lymphocyte Infusion in for a Patient with Recurrent Myeloid Sarcoma after Reduced Intensity Stem Cell Transplantation

黒田 裕行, 平山 泰生, 井山 諭

内科 ( 南江堂 )  109 ( 5 ) 893 - 896  2012.05

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P-0322 多発性骨髄腫に対するレナリドミド療法の有害事象の解析と薬剤管理指導(一般演題 ポスター発表,がん薬物療法(その他),Enjoy Pharmacists' Lifestyles)

中村 勝之, 野田 師正, 安井 寛, 池田 博, 林 敏昭, 石田 禎夫, 篠村 恭久, 村瀬 和幸, 井山 諭, 佐藤 勉, 瀧本 理修, 小船 雅義, 加藤 淳二, 中田 浩雅, 宮本 篤

日本医療薬学会年会講演要旨集 ( 日本医療薬学会 )  21   235 - 235  2011.09

CiNii

A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine

Sho Takahashi, Yasushi Sato, Tamotsu Sagawa, Shingo Tanaka, Kazuyuki Murase, Kohichi Takada, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Ganji Kuroiwa, Michiaki Hirayama, Tetsuro Okamoto, Junji Kato

Journal of Japanese Society of Gastroenterology ( The Japanese Society of Gastroenterology )  108 ( 8 ) 1405 - 1412  2011.08

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A 64-year-old man had been admitted to a previous hospital because of melena and a diagnosis of ulcerative colitis (UC, pancolitis type) had been made. He had received prednisolone and 5-ASA but steroid-induced hyperamylasemia had developed. Prednisolone had been tapered and halted, but it had resulted in UC relapse and thrombocytopenia. Then, he was referred to our hospital due to severe melena with hypovolemic shock. However, he was also positive for CMV antigen. Thus, we attempted to treat him with ganciclovir for CMV and intravenous cyclosporine (CsA) for UC. According to his clinical course, a reduction of CsA blood concentration induced leukocytopenia. Myelodysplastic syndrome (MDS, RAEB-1) was then revealed after bone marrow biopsy. A high blood CsA concentration may cause the improvement of UC and MDS conditions.

DOI PubMed CiNii

Case report: Successful treatment of refractory hemophagocytic lymphohistiocytosis with infliximab in a rheumatoid arthritis patient

黒田 裕行, 井山 諭, 照井 健

内科 ( 南江堂 )  108 ( 1 ) 164 - 167  2011.07

CiNii

Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer

Masahiro Hirakawa, Yasushi Sato, Hiroyuki Ohnuma, Tamotsu Sagawa, Hirotoshi Ishiwatari, Kazuyuki Murase, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

Journal of Japanese Society of Gastroenterology ( The Japanese Society of Gastroenterology )  108 ( 2 ) 231 - 237  2011.02

　View Summary

A 75-year-old man received chemoradiotherapy (CRT) for stage IVa esophageal cancer and complete response (CR) was obtained. However, he was referred to our department for recurrence in an area of esophagus not included in the previously irradiated field. Left pleural effusion increased after admission. Tuberculous pleuritis was eventually diagnosed by thoracoscopic pleural biopsy. It is necessary to accurately diagnose the cause of pleural effusion after CRT, because treatment strategies greatly depend on it. It is also necessary to consider the possible onset of tuberculous pleuritis, in particular, in patients with a history of tuberculosis infection.

DOI PubMed CiNii

Long-Term Production System of Red Blood Cells Using Human Cord Blood and Stromal Cells.

Masayoshi Kobune, Shohei Kikuchi, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  116 ( 21 ) 1317 - 1317  2010.11

Research paper, summary (international conference)  

SUCCESSFUL TREATMENT OF HCC SIZED 10MM BY COINFECTION OF REPLICATION COMPETENT ADV AND ADVP53 WITH AFPPROMOTERS, AND LOW DOSE 5-FU IN COMBINATION

Tamotsu Sagawa, Yasuyuki Yamada, Minoru Takahashi, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Junki Fukaura, Satoshi Iyama, Tsutomu Sato, Takuya Matsunaga, Junji Kato, Katsunori Sasaki, Hirofumi Hamada, Yoshiro Niitsu

JOURNAL OF GENE MEDICINE ( JOHN WILEY & SONS LTD )  11 ( 12 ) 1161 - 1161  2009.12

Research paper, summary (international conference)  

Cyclopamine Induced Apoptosis in Primary CD34+Acute Leukemic Cells.

Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Yasushi Sato, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  114 ( 22 ) 1450 - 1450  2009.11

Research paper, summary (international conference)  

CD34+Cobblestone Area-Forming Cells Are a Valuable Indicator to Screen the Soluble Inhibitors of Hematopoiesis in the Serum of Aplastic Anemia and MDS Patients.

Shohei Kikuchi, Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yutaka Kawano, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  114 ( 22 ) 584 - 584  2009.11

Research paper, summary (international conference)  

Acute mesenteric ischemia associated with thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus

井山 諭, 佐藤 勉, 小船 雅義

内科 ( 南江堂 )  104 ( 3 ) 575 - 578  2009.09

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Successful induction of complete remission by gemtuzumab ozogamicin following chemotherapy in three patients with relapsed or refractory acute myeloid leukemia

HIRAYAMA Yasuo, TERUI Takeshi, KOIKE Kazuhiko, NEDA Hiroshi, ISHITANI Kunihiko, KOHDA Kyuhei, KURODA Hiroyuki, IYAMA Satoshi, SATO Tsutomu, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji

The Japanese journal of clinical hematology ( 「臨床血液」編集部 )  50 ( 8 ) 663 - 665  2009.08

DOI CiNii

Wnt3 Signaling Augments integrin beta 1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner

Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  112 ( 11 ) 599 - 600  2008.11

Research paper, summary (international conference)  

Interaction with Human Stromal Cells Enhances CXCR4 Expression and Engraftment of Cord Blood Lin-CD34-Cells Via Writ Signaling.

Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Shohei Kikuchi, Yutaka Kawano, Kohichi Takada, Koji Miyanishi, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  112 ( 11 ) 810 - 810  2008.11

Research paper, summary (international conference)  

SUCCESSFUL REMOVAL OF FOREIGN BODIES LOCATED IN THE SMALL BOWEL USING DOUBLE BALLOON ENTEROSCOPY

SAGAWA Tamotsu, TAKAYAMA Tetsuji, SATO Yasushi, TAKAHASHI Sho, TANAKA Shingo, OZASA Risa, IYAMA Satoshi, KURODA Hiroyuki, KATO Junji, NIITSU Yoshiro

日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy   50 ( 10 ) 2684 - 2690  2008.10

DOI CiNii

骨髄腫から産生されるWnt3はRhoA/ROCKシグナルを活性化し、インテグリンα6β1依存性のCAM-DRを惹起する

小船 雅義, 河野 豊, 井山 諭, 佐藤 勉, 瀧本 理修, 松永 卓也, 加藤 淳二, 濱田 洋文, 新津 洋司郎

臨床血液 ( (一社)日本血液学会-東京事務局 )  48 ( 9 ) 870 - 870  2007.09

A CASE OF PYLORIC STENOSIS AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION OF EARLY GASTRIC CANCER

SAGAWA Tamotsu, SATO Yasushi, TAKAYAMA Tetsuji, ABE Seiichiro, HIRAKAWA Masahiro, ARAKI Naoko, OZASA Risa, IYAMA Satoshi, KATO Junji, NIITSU Yoshiro

日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy   49 ( 7 ) 1681 - 1687  2007.07

DOI CiNii

[Superior mesenteric and portal vein thrombosis in a polycythemia vera patient with JAK2 mutation].

Naoko Araki, Rishu Takimoto, Hiroki Chiba, Hironobu Araki, Tsutomu Sato, Satoshi Iyama, Masahiro Hirakawa, Kaoru Ono, Yutaka Kawano, Koichi Takada, Koji Miyanishi, Masayoshi Kobune, Takuya Matsunaga, Junji Kato, Tokiko Nakamura, Yoshiro Niitsu

[Rinsho ketsueki] The Japanese journal of clinical hematology ( 日本臨床血液学会 )  48 ( 7 ) 554 - 8  2007.07  [Domestic journal]

　View Summary

A 47-year-old woman was admitted to our hospital in December 1994 with polycythemia. The patient's red blood cell volume was 33 ml/kg and bone marrow cytology was able to rule out other myeloproliferative diseases such as chronic myelogenous leukemia, essential thrombocytosis and myelofibrosis. The patient was diagnosed as having polycythemia vera. She had undergone only phlebotomy until 1999 when the thrombocytosis appeared, subsequent to which she was treated with oral hydroxyurea. However, in March 2006, she developed upper abdominal pain and was admitted to our hospital on March 14th, 2006. Computed tomography scan revealed thromboses in the portal and superior mesenteric veins. Anticoagulation therapy delivered intravenously via the superior mesenteric vein dramatically improved her symptoms and liver function. She is currently on anticoagulation therapy in our outpatient clinic.

DOI PubMed CiNii

Factor XI deficiency caused by a mutation of Gly400Val

SATO Tsutomu, IYAMA Satoshi, ARAKI Naoko, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, MATSUNAGA Takuya, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology   48 ( 2 ) 148 - 150  2007.02

DOI CiNii

Gastric relapse of stage I ocular adnexal : mucosa-associated lymphoid tissue lymphoma

SATO Tsutomu, TAKIMOTO Rishu, IYAMA Satoshi, ONO Kaoru, TANAKA Shingo, ARAKI Naoko, NISHIIE Kiwami, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, MATSUNAGA Takuya, KATO Junji, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  48 ( 1 ) 56 - 60  2007.01

　View Summary

A 57-year-old male with right ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) was successfully treated with local radiation therapy. The gastroendoscopic examination revealed a slight inflammatory change of the gastric mucosa, and the urease test was positive. Eradication therapy against Helicobacter pylori was successfully done, however, the patient developed gastric MALT lymphoma two years after the initial treatment. Southern blot analysis of the immunoglobulin heavy chain gene rearrangement revealed that the lymphoma cells from the ocular adnexal and gastric MALT lymphomas were identical, indicating that the gastric MALT lymphoma was not the primary but the metastatic region from the ocular adnexal MALT lymphoma. Further, immunohistochemical staining demonstrated the expression of integrin α4β7 on ocular adnexal MALT lymphoma cells, which is essential for the adhesion of lymphocytes to gastrointestinal mucosa. These results indicate that ocular adnexal MALT lymphoma cells can metastasize to the stomach, depending on the adhesional function of integrin α4β7.

DOI CiNii

Report of an autopsy case of colon cancer with amyotrophic lateral sclerosis

Yasushi Sato, Tetsuji Takayama, Tomomi Nikaido, Yuko Wada, Tamotsu Sagawa, Seiichiro Abe, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Hironobu Araki, Yasuhiro Sato, Junji Kato, Yoshiro Niitsu, Hideki Chiba

Japanese Journal of Gastroenterology ( The Japanese Society of Gastroenterology )  104 ( 9 ) 1365 - 1370  2007

　View Summary

Amyotrophic lateral sclerosis (ALS) is a degenerative disease involving both upper and lower motor neurons and the pathogenesis of this disorder is still unknown. To date, few reports have suggested that motor neuron diseases may have a paraneoplastic origin. However, it is still under discussion whether ALS occurring in cancer patients is paraneoplastic. A 60-year-old man with rectal cancer (Stage IV) having multiple lung, liver and para-aortic lymph node metastases underwent anterior resection of the rectum as palliative surgery. He was referred to our hospital for adjuvant chemotherapy. Lung and lymph node metastases decreased after 2 courses of chemotherapy using CPT-11 and 5-FU/LV but liver metastases were enlarged, following up increase in CEA. Thereafter, he suffered from muscle weakness in hands, arms, and legs and results of neurophysiologic studies were compatible with primary lateral sclerosis (ALS). For second line chemotherapy, he was treated with low-dose CDDP/5-FU over 6 courses. As a result, the size the of metastatic lesions markedly reduced and CEA was decreased to the normal level. Although significant tumor reduction was observed, his neurological symptoms rapidly progressed. He died of aspiration pneumonia 8 months after onset of the disease. Autopsy revealed that his neuropathological findings were compatible with ALS, and it was thought to be the primary cause of death in the because of absence of cancer progression. In this case the neurological syndrome was not affected by cancer therapy. Thus our case does not support the hypothesis that ALS in associated with cancer and the relationship between both disorders remains uncertain.

DOI PubMed CiNii

Peripheral T-cell lymphoma presenting with eosinophilia due to Interleukin-5 produced by lymphoma cells

MATSUNAGA Takuya, SATO Tsutomu, IYAMA Satoshi, TANAKA Shingo, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  47 ( 11 ) 1457 - 1462  2006.11

　View Summary

A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.

DOI CiNii

A case of recurrent biliary cystadenocarcinoma successfully treated with 5FU/CDDP systemic chemotherapy

Satoshi Iyama, Yasuo Takahashi, Naoaki Shintani, Koshi Fujikawa, Syunichi Ohkubo, Yasushi Sato, Tsutomu Sato, Yasuhiro Sato, Keisuke Ohnuma, Yoshiro Niitsu

Japanese Journal of Gastroenterology ( The Japanese Society of Gastroenterology )  103 ( 10 ) 1163 - 1168  2006.10

　View Summary

We report a case of biliary cystadenocarcinoma which recurred 41 months postoperatively. A 60-year-old woman was admitted for further examination of multiple metastatic tumors and a large amount of ascites. Systemic administration of 5FU and CDDP caused her CEA level to decrease gradually and abdominal computed tomography revealed considerable reduction of the metastatic tumors and ascites. Since her general condition had improved, chemotherapy was continued in the outpatient clinic.

DOI PubMed CiNii

De novo CD5-positive diffuse large B-cell lymphoma associated with autoimmune hemolytic anemia presenting as erythroid hypoplasia

KURODA Hiroyuki, MATSUNAGA Takuya, IYAMA Satoshi, TAKIMOTO Rishu, SHIRAO Sayaka, KIDA Masaya, WATANABE Hideki, KONUMA Yu-ichi, HIRAYAMA Yasuo, KOHDA Kyuhei, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology ( 日本臨床血液学会 )  47 ( 7 ) 633 - 638  2006.07

DOI CiNii

Enteropathy-type T-cell lymphoma with CD8 and CD56 expression

SATO Tsutomu, MATSUNAGA Takuya, IYAMA Satoshi, SAKAI Toshiro, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology ( 日本臨床血液学会 )  47 ( 7 ) 645 - 649  2006.07

DOI CiNii

A case of metastatic small bowel and gastric cancer from the lung caused intussusception

井山 諭, 高橋 康雄, 新谷 直昭

Japanese journal of cancer clinics ( 篠原出版新社 )  52 ( 2 ) 77 - 83  2006

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Diagnostic utility of fluorescence in situ hybridization (FISH) in mantle cell lymphoma in leukemic phase

井山 諭, 松永 卓也, 佐藤 勉

Japanese journal of cancer clinics ( 篠原出版新社 )  52 ( 6 ) 455 - 461  2006

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Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient

IYAMA Satoshi, MATSUNAGA Takuya, FUJIMI Akihito, MURASE Kazuyuki, KURIBAYASI Kageaki, SATO Tsutomu, HIRAYAMA Yasuo, SAKAMAKI Sumio, KOHDA Kyuhei, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  46 ( 5 ) 363 - 367  2005.05

　View Summary

A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling. Adenovirus type 11 hemorrhagic cystitis developed and progressed to nephritis and hemophagocytic syndrome. Oral ribavirin was effective not only for the hemorrhagic cystitis and nephritis but also for the hemophagocytic syndrome. Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.

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11. 臍帯血移植後にドナー細胞由来の急性骨髄性白血病(AML)を発症した成人T細胞性白血病リンパ腫(ATLL)(日本アフェレシス学会第24回北海道地方会抄録)(<特集>アフェレシスにおけるセイフティーマネジメント)

村瀬 和幸, 松永 卓也, 栗林 景晶, 井山 諭, 菊池 尚平, 藤見 章仁, 新津 洋司郎, 古川 勝久

日本アフェレシス学会雑誌 ( 日本アフェレシス学会 )  24 ( 1 ) 121 - 121  2005.02

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A novel treatment for early gastrointestinal carcinoma by ultrasonic endoscopic mucosal stripping

OHTA Hidetoshi, SHINTANI Naoaki, FUJIKAWA Koshi, IYAMA Satoshi, TAKAHASHI Yasuo, NOBUOKA Atsushi, DOI Tadashi, NAKAMURA Tokiko, TAKAYAMA Tetsuji, NATORI Hiroshi

Journal of medical ultrasonics : official journal of the Japan Society of Ultrasonics in Medicine   31 ( 4 ) 141 - 148  2004.12

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免疫療法の進歩 (特別企画 がんの最新知識)

佐藤 勉, 井山 諭, 新津 洋司郎

からだの科学 ( 日本評論社 )  ( 238 ) 86 - 91  2004.09

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A case of primary biliary cirrhosis with HLA-DR 8 complicated by polymyositis

SATO Tsutomu, KATO Junji, SATO Yasushi, IYAMA Satoshi, TAKADA Kohichi, OKU Takatomi, TAKAHASHI Sho, MACHIDA Takurou, KOBUNE Masayoshi, MATSUNAGA Takuya, TAKAHASHI Minoru, NIITSU Yoshiro

Kanzo ( The Japan Society of Hepatology )  44 ( 9 ) 455 - 459  2003.09

　View Summary

症例は64歳, 女性. 皮膚掻痒感, 四肢の筋力低下を主訴として入院した. 血液検査では, 胆道系酵素, 筋原性酵素の上昇を認め, 抗核抗体, 抗ミトコンドリア抗体(AMA), 抗M2抗体が陽性であった. 肝生検では慢性非化膿性破壊性胆管炎を, 筋生検では筋線維の大小不同および円形萎縮を認めた. 原発性胆汁性肝硬変(PBC)と多発性筋炎の合併と診断し, ウルソデオキシコール酸およびプレドニゾロンを投与したところ, 検査所見と自覚症状は改善した. PBCは稀に多発性筋炎を合併するが, その機序としてAMAによる筋組織のミトコンドリア障害が想定されている. 本症例でも電子顕微鏡観察において, 特徴的なミトコンドリアの増加が観察された. 更に, 多発性筋炎の発症要因とされるHLA-DR 8が陽性であった. このことは, 患者の免疫学的な背景も多発性筋炎の合併に関与する可能性を示唆すると考えられた.

DOI CiNii

A case of cholangiocellular carcinoma effectively treated with combination chemotherapy of gemcitabine and 5-FU

TAKANASHI Kunihiro, HOMMA Hisato, MEZAWA Shin-ichi, DOI Tadashi, AKIYAMA Takehide, HIRATA Ken-ichiro, IYAMA Satoshi

Kanzo ( The Japan Society of Hepatology )  44 ( 6 ) 301 - 306  2003.06

　View Summary

症例は78歳, 女性. 主訴は腹部不快感. 肝S2/3に63×44mmの腫瘤と腫瘤末梢側の肝内胆管の拡張, 腹部リンパ節の腫大を認めた. 各種画像診断及び針生検にて胆管細胞癌と診断. Gemcitabine, 5-FU併用化学療法にて腫瘍はほとんど同定できないまでに縮小し, リンパ節腫大も消失, 治療効果判定はPRであった. 切除不能胆管細胞癌の予後は不良であるが, 本療法は有効な治療選択の一つになり得ると考えられた.

DOI CiNii

A case of polyarteritis nodosa treated by methotrexate: Follow-up study of hepatic arteriography

Kunihiro Takanashi, Hisato Homma, Shin-Ichi Mezawa, Tadashi Doi, Takehide Akiyama, Ken Murakami, Koichi Takada, Takehiro Kukitsu, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yoshiro Niitsu

Acta Hepatologica Japonica ( Japan Society of Hepatology )  44 ( 12 ) 649 - 655  2003

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Successful treatment of advanced peripheral T-cell lymphoma with an angiocentric growth pattern complicated with hemophagocytic syndrome by high-dose chemotherapy and autologous peripheral blood stem cell transplantation

T Sato, K Kogawa, S Iyama, D Kobayashi, Y Sato, K Kuribayashi, K Takada, S Hagiwara, T Oku, S Takahashi, T Matsunaga, M Takahashi, T Terui, J Kato, Y Niitsu

ANNALS OF HEMATOLOGY ( SPRINGER-VERLAG )  81 ( 12 ) 739 - 743  2002.12

　View Summary

Peripheral T-cell lymphomas (PTCL) account for about 10% of all lymphomas in Western countries, respond poorly to therapy, and have short survival with no sustained remission. Furthermore, the complication of hemophagocytic syndrome (HPS) sometimes makes the prognosis of this disease extremely worse. We report here a case of PTCL with an angiocentric growth pattern complicated with HPS successfully treated by high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Our case suggests this approach is an excellent candidate for the treatment of this disease.

DOI

<Abstract of Published Report>Treatment of murine collagen-induced arthritis by ex vivo extracellular superoxide dismutase gene transger.

IYAMA Satoshi, OKAMOTO Tetsuro, SATO Tsutomu, YAMAUCHI Naofumi, SATO Yasushi, SASAKI Katsunori, TAKAHASHI Minoru, TANAKA Maki, ADACHI Tetsuo, KOGAWA Katsuhisa, KATO Junji, SAKAMAKI Sumio, NIITSU Yoshiro

The annual proceedings of Gifu College of Pharmacy ( Gifu Pharmaceutical University )  51   82 - 82  2002.06

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A case of true malignant histiocytosis: identification of histiocytic origin with use of immunohistochemical and immunocytogenetic methods

T Sato, T Terui, K Kogawa, Y Nagaoka, Y Sato, S Iyama, K Takada, S Hagiwara, S Takahashi, T Oku, T Matsunaga, M Takahashi, J Kato, S Sakamaki, T Torigoe, N Sato, M Hirayama, Y Niitsu

ANNALS OF HEMATOLOGY ( SPRINGER-VERLAG )  81 ( 5 ) 285 - 288  2002.05

　View Summary

We report here an autopsy case of true malignant histiocytosis. The patient was a 67-year-old woman who exhibited fever, wasting, hepatosplenomegaly, and progressive pancytopenia. The bone marrow aspiration disclosed hemophagocytosing cells, which resembled histiocytes. The molecular analysis did not show the clonal gene rearrangement of T-cell receptor or immunoglobulin heavy chain. Although the patient had been started on methylprednisolone pulse therapy and chemotherapy with etoposide, she died from cerebral hemorrhage. The autopsy specimens of spleen and liver showed extensive infiltration of atypical cells, for which histiocytic origin was identified with an immunohistochemical method using monoclonal antibodies against CD11c, CD68, macrophage colony-stimulating factor (M-CSF), M-CSF receptor, lysozyme, antitrypsin and alpha1-antichymotrypsin. Recent investigations have disclosed that in most cases diagnosed as malignant histiocytosis, hemophagocytosis was reactive and not evoked by histiocytic malignancy. True malignant histiocytosis, for which histiocytic origin is confirmed, is extremely rare.

DOI

A case of pancreatic ascites due to rupture of pancreatic pseudocyst successfully treated with continuous arterial infusion of nafamostat mesilate

DOI Tadashi, HOMMA Hisato, MEZAWA Shinichi, KIDA Masaya, KUKITSU Takehiro, MIYANISHI Kouji, MURASE Kazuyuki, TAKADA Kouichi, IYAMA Satoshi, NIITSU Youshirou

Nippon Shokakibyo Gakkai Zasshi ( The Japanese Society of Gastroenterology )  98 ( 11 ) 1304 - 1308  2001.11

　View Summary

症例はアルコール性慢性膵炎を指摘されている66歳の男性．慢性膵炎の急性増悪の経過中に形成された膵仮性嚢胞の破綻による膵性腹水を発症した．経皮的腹腔ドレナージ，絶食，メシル酸ナファモスタットの経静脈投与などの保存的治療を行ったが内膵液痩が持続し，膵炎の遷延も認められたことからメシル酸ナファモスタットの持続動注療法を施行したところ膵性腹水は消失した．メシル酸ナファモスタット持続動注による膵炎の鎮静化によって内膵液痩の修復が促進されたものと考えられた．

DOI CiNii

Treatment of murine collagen-iduced arthritis by Ex-vivo EC-SOD gene transfer

IYAMA Satoshi

Japanese Journal of Clinical Immunology ( The Japan Society for Clinical Immunology )  23 ( 6 ) 542 - 542  2000.12

DOI CiNii

Pure red cell aplasia induced by clomipramine hydrochloride in a patient with SLE

SATO Tsutomu, KOGAWA Katsuhisa, HIRAYAMA Yasuo, SATO Yasushi, NOBUOKA Atsushi, KURIBAYASHI Kageaki, IYAMA Satoshi, TAKADA Kouichi, HAGIWARA Seiya, TAKAHASHI Shou, KATO Junji, SAKAMAKI Sumio, ISHIGAKI Seishi, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  41 ( 8 ) 648 - 652  2000.08

　View Summary

A 48-year-old woman, who had been suffering from systemic lupus erythematosus (SLE), developed normochromic normocytic anemia after receiving clomipramine hydrochloride. Her reticulocyte count was low, and a bone marrow aspirate revealed erythroid hypoplasia without involvement of other cell lines. Thus a diagnosis of pure red cell aplasia (PRCA) was made. The anemia gradually resolved following withdrawal of the drug. Although several drugs are known to cause PRCA, this is the first time that clomipramine hydrochloride has been reported to have such an effect. The underlying SLE in this case suggested the possible immunological pathogenesis of drug-induced PRCA.

DOI CiNii

A case of high molecular weight insulin-like growth factor-II (IGF-II)-producing hepatoma associated with frequent hypoglycemia and rapid-growth

SATO Tsutomu, KATO Juniji, HONMA Hisato, KURA Toshirou, OHI Motoo, MURAKAMI Ken, SATO Yasushi, IYAMA Satoshi, TAKADA Kouich, AGIWARA Seiya, TAKAHASHI Minoru, SAKAMAKI Sumio, NIITSU Yoshiro

Kanzo ( The Japan Society of Hepatology )  41 ( 5 ) 346 - 351  2000.05

　View Summary

症例は69歳の女性. 空腹時の手指振戦および冷汗を主訴として当科へ入院した. 入院時の血液検査は低血糖と肝硬変を示唆した. 肝炎ウイルスマーカーは, HBs抗原陽性, HBe抗体陽性, HCV抗体陰性. 血中インスリンは測定感度以下を示し, insulin-like growth factor-II (IGF-II) は高値であった. 画像では肝右葉に直径8.0cmの腫瘍を認め, 生検にてこれを中分化型肝細胞癌と診断した. 更に, 腫瘍細胞はIGF-IIの免疫染色に陽性で, ウエスタンブロットでは正常型IGF-II以外に高分子型IGF-IIが検出された. 抗癌剤の動注療法により, 繰り返す低血糖発作は一時的にコントロールされたが, 腫瘍の急速な増大に伴って再び頻繁となった. 短期間に腫瘍は肝全体を占めるに至り, 肝不全で患者は永眠した. 肝癌は稀に低血糖を合併するが, 一部の症例においてこの原因は腫瘍細胞の産生する高分子型IGF-IIであると推測されている. 一方, 低血糖を合併する肝癌は急速に増大するため予後不良であると報告されている. 今回我々は, 急速な増大を呈した低血糖合併肝癌において, 腫瘍細胞の高分子型IGF-II産生を確認した. 高分子型IGF-IIは低血糖を誘導するのみならず, 腫瘍細胞に対する増殖因子として働く可能性を示唆すると考え報告した.

DOI CiNii

潰瘍性大腸炎の経過中に再発性多発性軟骨炎を合併した1例

河野 豊, 山内 尚文, 由崎 直人, 岡本 哲郎, 高山 哲治, 井山 諭, 加藤 淳二, 坂牧 純夫, 平山 眞章, 西里 卓次

リウマチ ( (一社)日本リウマチ学会 )  40 ( 2 ) 546 - 546  2000.04

Evaluation of gastric cancer diameter using three dimensional helical CT

M Hirayama, Y Hirano, H Matsuya, M Iriyama, E Sasaki, Y Sato, Y Nishibori, S Son, T Sakawaki, J Fukaura, S Iyama, Y Niitsu

GASTROENTEROLOGY ( W B SAUNDERS CO-ELSEVIER INC )  116 ( 4 ) A422 - A422  1999.04

Research paper, summary (international conference)  

癌に対する遺伝子治療

高橋 稔, 井山 諭, 新津 洋司郎

Cancer frontier ( 医薬ジャーナル社 )  1 ( 1 ) 119 - 126  1999

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Three dimensional analysis for gastric cancer using helical CT scanners.

M Hirayama, J Fukaura, Y Hirano, H Matsuya, M Iriyama, E Sasaki, Y Urushizaki, N Ohmi, T Sakawaki, T Kurotaki, S Iyama, H Muramatsu, M Kida, Y Niitsu

GASTROENTEROLOGY ( W B SAUNDERS CO )  114 ( 4 ) A611 - A611  1998.04

Research paper, summary (international conference)