Papers - TAKADA Kouichi

血液疾患患者におけるCOVID-19感染症4例の報告(Four cases of COVID-19 patients with hematological malignancy)

小野 賢人, 堀口 拓人, 下山 紗央莉, 藤田 千紗, 後藤 亜香利, 池田 博, 井山 諭, 村瀬 和幸, 高田 弘一, 藤谷 好弘, 高橋 聡, 黒沼 幸治, 小船 雅義

日本血液学会学術集会 ( (一社)日本血液学会 )  83回   OS3 - 4  2021.09

Eribulin in combination with HER2-targeted antibodies for successful treatment of metastatic salivary duct carcinoma: A report of two cases

Akihito Fujimi, Yasuhiro Nagamachi, Naofumi Yamauchi, Takuji Nishisato, Kazuyuki Murase, Kohichi Takada, Mitsuhiro Tsujiwaki, Shintaro Sugita, Tadashi Hasegawa, Junji Kato

Oral Oncology ( Elsevier BV )  120   105287 - 105287  2021.04  [Refereed]  [International journal]

DOI PubMed

A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis

Taro Murakami, Akira Takasawa, Asako Moriki, Yusuke Igaki, Hiroshi Ikeda, Kazuyuki Murase, Kohichi Takada, Kazufumi Magara, Tomoyuki Aoyama, Yusuke Ono, Daisuke Kyuno, Kumi Takasawa, Masaki Murata, Makoto Osanai

Virchows Archiv ( Springer Science and Business Media LLC )  479 ( 5 ) 1041 - 1046  2021.03  [Refereed]  [International journal]

　View Summary

Amyloidosis is induced by extracellular deposition of certain proteins. Thirty-six proteins have so far been identified as amyloidogenic proteins in humans. Although it is very important to determine the specific amyloid protein type for the choice of therapy for amyloidosis patient, it might be difficult to identify specific proteins from amyloid-deposited tissue. Apolipoprotein A-IV is known as an amyloid-associated protein, but there have been few reports of apolipoprotein A-IV amyloidosis. Here we report a case of systemic apolipoprotein A-IV-associated amyloidosis that was confirmed by proteome analysis using formalin-fixed paraffin-embedded tissue and an immunohistochemical technique.

DOI PubMed

Possible clinical outcomes using early enteral nutrition in individuals with allogeneic hematopoietic stem cell transplantation: A single-center retrospective study

Satoshi Iyama, Hiroomi Tatsumi, Tsukasa Shiraishi, Masahiro Yoshida, Ayumi Tatekoshi, Akihito Endo, Taichiro Ishige, Yuh Shiwa, Soushi Ibata, Akari Goto, Kana Nagashima, Hiroto Horiguchi, Chisa Fujita, Hiroshi Ikeda, Kohichi Takada, Takayuki Nobuoka, Yusuke Kamihara, Shohei Kikuchi, Tsutomu Sato, Hirofumi Ohnishi, Shin-ichi Yokota, Masayoshi Kobune

Nutrition ( Elsevier BV )  83   111093 - 111093  2021.03  [Refereed]

DOI

食道癌 診断と治療のup to date 食道腺癌を含めて 切除可能進行食道癌に対する三剤併用療法ベースの化学放射線療法は手術療法を代替できるか?:傾向スコアマッチング分析

大沼 啓之, 小野山 直輝, 濱口 孝太, 早坂 尚貴, 佐藤 昌則, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 村上 武志, 伊東 竜哉, 信岡 隆幸, 竹政 伊知朗, 土屋 高旭, 長谷川 智一, 堀 正和, 染谷 正則, 坂田 耕一, 加藤 淳二

日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 )  128回・122回   35 - 35  2021.03

A case of hypervascular tumors in the liver and pancreas: synchronous hepatocellular carcinoma and pancreatic metastasis from renal cell carcinoma 36 years after nephrectomy

Hajime Nakamura, Shingo Tanaka, Koji Miyanishi, Yutaka Kawano, Takahiro Osuga, Kazuma Ishikawa, Makoto Yoshida, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Hiroshi Yamaguchi, Minoru Nagayama, Yasutoshi Kimura, Ichiro Takemasa, Junji Kato

Clinical Case Reports ( Wiley )  9 ( 2 ) 932 - 937  2021.02  [Refereed]

DOI

Acanthopanax senticosus Harms extract causes G0/G1 cell cycle arrest and autophagy via inhibition of Rubicon in human liver cancer cells

Yutaka Kawano, Maki Tanaka, Masaki Fujishima, Eri Okumura, Hideo Takekoshi, Kohichi Takada, Osamu Uehara, Yoshihiro Abiko, Hidekatsu Takeda

Oncology Reports ( Spandidos Publications )  45 ( 3 ) 1193 - 1201  2021.01  [Refereed]

　View Summary

© 2021 Spandidos Publications. All rights reserved. Acanthopanax senticosus (Rupr. et Maxim) Harms (ASH), also known as Siberian ginseng or eleuthero, is a hardy shrub native to China, Korea, Russia and the northern region of Japan. ASH is used for the treatment of several diseases such as heart disease, hypertension, rheumatoid arthritis, allergies, chronic bronchitis, diabetes and cancer. In the present study, the inhibitory effect of the root extract of ASH (ASHE) on HuH-7 and HepG2 liver cancer cells was examined. ASHE suppressed liver cancer cell proliferation by inducing cell cycle arrest at the G0/G1 phase, as well as apoptosis, as indicated by the increased number of Annexin V and 7-AAD-positive cells. Furthermore, the expression of LC3-II, an autophagy marker, in these cells also increased post treatment with ASHE. LC3-II induction was further enhanced by co-treatment with chloroquine. Fluorescence and transmission electron micrographs of ASHE-treated liver cancer cells showed the presence of an increased number of autophagic vesicles. A decreased protein expression level of run domain Beclin-1-interacting and cysteine-rich domain-containing, an autophagy inhibitor, with no change in RUBCN mRNA expression was observed, indicating activation of the autophagosome-lysosome fusion step of autophagy. In conclusion, ASHE exerts cytostatic activity on liver cancer cells via both apoptosis and autophagy, and may serve as a potential therapeutic agent for management of liver cancer and autophagy-related diseases.

DOI

Cardiac Light Chain Deposition Disease Mimicking Immunoglobulin Light Chain Amyloidosis

Arata Osanami, Toshiyuki Yano, Genzou Takemura, Hiroshi Ikeda, Masafumi Inyaku, Yuki Toda, Naoyuki Kamiyama, Hirohito Sugawara, Yufu Gocho, Takefumi Fujito, Nobutaka Nagano, Satoko Takahashi, Atsuko Muranaka, Marenao Tanaka, Norihito Moniwa, Kazuyuki Murase, Kohichi Takada, Hiroyuki Kuroda, Yayoi Ogawa, Tetsuji Miura

Circulation: Cardiovascular Imaging ( Ovid Technologies (Wolters Kluwer Health) )  13 ( 9 ) e010478  2020.09  [Refereed]  [International journal]

DOI PubMed

Two cases of synchronous multicentric invasive ductal carcinomas of the pancreas

Yuki Ikeda, Makoto Yoshida, Kazuma Ishikawa, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Ichiro Takemasa, Tadashi Hasegawa, Junji Kato

Gastroenterological Endoscopy ( Japan Gastroenterological Endoscopy Society )  62 ( 7 ) 785 - 792  2020.07

　View Summary

Case 1: A 64-year-old female with obstructive jaundice, suggesting the presence of pancreatic head tumor, was admitted to our hospital. Enhanced computed tomography (CT) showed a pancreatic head mass, while endoscopic ultrasound (EUS) detected two masses (i.e., pancreatic head and body). Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) was performed, and the two masses were identified as adenocarcinoma. The patient underwent subtotal stomach-preserving pancreatoduodenectomy. The pancreatic head and body masses were moderately and well differentiated adenocarcinoma, respectively. Case 2: A 78-year-old female was admitted to our hospital due to suspicion of a pancreatic body tumor. Enhanced CT showed a pancreatic tail mass, while EUS detected two masses (i.e., pancreatic body and tail). EUS-FNA was performed, and the two masses were identified as adenocarcinoma. The patient underwent distal pancreatectomy. Both masses were well differentiated adenocarcinoma, and could be distinguished histologically/ morphologically. The use of preoperative EUS-FNA is necessary to confirm the presence of multiple lesions in patients with initial detection of a pancreatic mass.

DOI

Acquired amegakaryocytic thrombocytopenic purpura possibly induced by anti-PD-1 antibody

Satoshi Iyama, K. Takada, M. Yoshida, D. Takahashi, M. Kobune

Annals of Hematology ( Springer Science and Business Media LLC )  99 ( 7 ) 1669 - 1670  2020.07

DOI

粘液癌成分を伴った浸潤性膵管癌破裂の1切除例

久保 智洋, 村松 丈児, 吉田 真誠, 木内 隆之, 杉田 真太朗, 奥田 敏徳, 南 伸弥, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 長谷川 匡, 加藤 淳二

膵臓 ( (一社)日本膵臓学会 )  35 ( 3 ) A437 - A437  2020.07

Pancreatic cancer with leptomeningeal carcinomatosis: case report and literature review

Yuki Ikeda, Makoto Yoshida, Kazuma Ishikawa, Tomohiro Kubo, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Junji Kato

International Cancer Conference Journal ( Springer Science and Business Media LLC )  9 ( 2 ) 96 - 100  2020.04  [Refereed]

DOI

切除可能進行食道癌に対する三剤併用療法ベースの化学放射線療法は手術療法を代替できるか? 傾向スコアマッチング分析

大沼 啓之, 小野山 直輝, 濱口 孝太, 早坂 尚貴, 佐藤 昌則, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 伊東 竜哉, 信岡 隆幸, 竹政 伊知朗, 長谷川 智一, 堀 正和, 染谷 正則, 坂田 耕一, 加藤 淳二

日本消化器病学会北海道支部例会プログラム・抄録集 ( 日本消化器病学会-北海道支部 )  126回   50 - 50  2020.03

Pulmonary metastasectomy is associated with prolonged survival among patients with bone and soft tissue sarcoma

Junya Shimizu, Makoto Emori, Yasutaka Murahashi, Tomoko Sonoda, Taijiro Mishina, Masahiro Miyajima, Atsushi Watanabe, Shintaro Sugita, Kohichi Takada, Kazuyuki Murase, Tadashi Hasegawa, Toshihiko Yamashita

Molecular and Clinical Oncology ( Spandidos Publications )  12 ( 5 ) 429 - 434  2020.02  [Refereed]  [International journal]

　View Summary

The aim of the present study was to evaluate the survival impact of surgical resection among patients with pulmonary metastases from bone and soft tissue sarcomas. A total of 34 consecutive patients with ≤5 pulmonary metastases from bone and soft tissue sarcomas were retrospectively reviewed. The patients included 19 men and 15 women, with a median age of 64.0 years and a median follow-up of 14.5 months. The oncological outcome was compared between patients who underwent surgical and non-surgical treatment. A total of 22 patients underwent surgery and 12 patients did not undergo surgery. The surgery group had 3- and 5 year overall survival rates of 62 and 53%, respectively. None of the patients in the non-surgery group survived to 3 years. Compared with the non-surgery group, surgery achieved significantly better 3- and 5 year overall survival rates. Pulmonary metastasectomy was associated with significantly improved survival among patients who were aged <64 years (P=0.0155), as well as those who were aged ≥64 years (P=0.0444), which indicated that age was not associated with a difference in survival between the two groups. Therefore, pulmonary metastasectomy may improve the prognosis of patients with pulmonary metastases from bone and soft tissue sarcomas.

DOI PubMed

Efficacy of combination therapy with dexmedetomidine for benzodiazepines-induced disinhibition during endoscopic retrograde cholangiopancreatography

Yuki Ikeda, Makoto Yoshida, Kazuma Ishikawa, Tomohiro Kubo, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Masayoshi Kobune, Junji Kato

Therapeutic Advances in Gastroenterology ( SAGE Publications )  13   175628482091182 - 175628482091182  2020.01  [Refereed]

　View Summary

Benzodiazepines (BZDs) and analgesics are widely used for conscious sedation during endoscopic ultrasound (EUS) or endoscopic retrograde cholangiopancreatography (ERCP). However, endoscopic procedures are sometimes discontinued because of BZD-induced disinhibitory reactions such as excessive movement. We evaluated the usefulness of dexmedetomidine (DEX) for BZD-induced disinhibition in ERCP. Between February 2018 and August 2019, 22 patients who underwent EUS or ERCP were enrolled. All patients showed BZD-induced excessive movement at the first examination (BZD group) and received DEX at the second examination (DEX group). The initial DEX dose was 6 μg/kg/h for a 10-min loading, followed by 0.4 μg/kg/h during the procedure. BZDs and analgesics were administered before scope insertion. An additional sedative was administered to achieve a Ramsay sedation scale (RSS) of 4–5. Sedative effect, procedure completion rate, and changes in circulatory and respiratory dynamics were evaluated. Mean RSS scores were significantly higher ( p < 0.001) in the DEX (5.1 ± 0.5) compared with the BZD (4.0 ± 0.5) group. The movement score ( p < 0.001) and number of additional sedatives required ( p < 0.01) were lower in the DEX group. The procedure completion rate was significantly higher in the DEX (95.5%) compared with the BZD group (63.6%; p < 0.05). Significant differences in the frequency of hypotension ( p = 1.00), bradycardia ( p = 0.22), and respiratory depression ( p = 0.68) were not noted between groups. The addition of DEX to BZD therapy yielded better sedative efficacy, lower excessive movement, a reduction in BZDs used, and a higher procedure complete rate. DEX may be used as an alternative method for BZD-induced inhibition during ERCP.

DOI

Management of Multiple Arteriovenous Malformations of the Small Bowel

Masahiro Hirakawa, Rie Ishizuka, Masanori Sato, Naotaka Hayasaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Tatsuya Ito, Takayuki Nobuoka, Koji Miyanishi, Masayoshi Kobune, Ichiro Takemasa, Junji Kato

Case Reports in Medicine ( Hindawi Limited )  2019   1 - 4  2019.12  [Refereed]

　View Summary

A 62-year-old Japanese female was referred to our hospital with gastrointestinal bleeding. Although small-bowel bleeding was suspected, no bleeding source was identified by enhanced computed tomography (CT), video capsule endoscopy (VCE), and double-balloon enteroscopy (DBE). Five years later, the patient had recurrent intermittent bloody stools with a significant decrease in hemoglobin levels. Although no active bleeding was observed on antegrade DBE, we detected a pulsatile submucosal uplift accompanied by a small red patch on the top of the uplift in the jejunum. Arteriovenous malformation (AVM) was suspected as the cause of small-bowel bleeding. Multiple-phase CT showed a number of small vascular ectasias during the arterial phase in the jejunum, and we confirmed the presence of multiple AVMs in the jejunum by selective angiography. To identify the location of the lesions and determine the minimal surgical margins, we performed intraoperative selective angiography with indocyanine green (ICG) injection. This technique allowed us to clearly observe the region and perform segmental small-bowel resection with minimal surgical margin. The patient reported that she has had no gastrointestinal bleeding at the two years follow-up visit.

DOI

BH3 profiling discriminates the anti‑apoptotic status of 5‑fluorouracil‑resistant colon cancer cells.

Kazuma Ishikawa, Yutaka Kawano, Yohei Arihara, Tomohiro Kubo, Kohichi Takada, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato

Oncology reports ( Spandidos Publications )  42 ( 6 ) 2416 - 2425  2019.12  [Refereed]  [International journal]

　View Summary

5‑Fluorouracil (5‑FU) is a cytotoxic anticancer drug commonly used for patients with advanced colon cancer. This drug effectively reduces the size of tumors to a certain degree; however, cancer cells can gradually acquire resistance, resulting in disease progression. To identify the mechanism of 5‑FU resistance, we established three 5‑FU‑resistant colon cancer cell lines and analyzed both apoptosis‑related protein expression levels and BH3 profiling. These 5‑FU‑resistant colon cancer cell lines acquired apoptotic resistance to 5‑FU. Although apoptosis‑related protein expression levels were altered in each 5‑FU‑resistant colon cancer cell line variably, BH3 profiling indicated BCLXL dependence in 5‑FU‑resistant HT‑29 cells only. Functional BCLXL inhibition in 5‑FU‑resistant HT‑29 cells not only sensitized the cells to apoptosis but also overcame 5‑FU resistance. The apoptotic BIM protein was preferentially sequestered, thereby resulting in acquired dependence on BCLXL for survival. Additionally, in vivo models showed that BCLXL inhibition controlled tumor progression. These results indicate that BH3 profiling facilitates the identification of the functional role of anti‑apoptotic proteins during drug resistance and has clinical implications for colon cancer in targeting specific proteins such as BCLXL.

DOI PubMed

局所進行食道癌に対するDocetaxel/Nedaplatin/5-FU・放射線同時併用療法(DNF-R)の第II相試験 アップデート解析

佐藤 昌則, 大沼 啓之, 早坂 尚貴, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 加藤 淳二, 平川 昌宏, 佐川 保, 堀 正和, 染谷 正則, 坂田 耕一

北海道医学雑誌 ( 北海道医学会 )  94 ( 2 ) 121 - 121  2019.11

Borderline Resectable膵癌に対する治療戦略

吉田 真誠, 石川 和真, 久保 智洋, 伊藤 亮, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 加藤 淳二, 本谷 雅代, 柾木 喜晴, 仲瀬 裕志, 木村 康利, 永山 稔, 今村 将史, 竹政 伊知朗

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  57回   SY15 - 4  2019.10

EPO-R+ myelodysplastic cells with ring sideroblasts produce high erythroferrone levels to reduce hepcidin expression in hepatic cells

Shogo Miura, Masayoshi Kobune, Hiroto Horiguchi, Shohei Kikuchi, Satoshi Iyama, Kazuyuki Murase, Akari Goto, Hiroshi Ikeda, Kohichi Takada, Koji Miyanishi, Junji Kato

Blood Cells, Molecules, and Diseases ( Elsevier BV )  78   1 - 8  2019.09  [Refereed]

DOI