Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2009

  -

  2011

  Sapporo Medical University   School of Medicine  

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Obstetrics and gynecology  

Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Mailing human papillomavirus self-sampling kits to women under-screened for cervical cancer improved detection in cervical cancer screening in a general population study in Japan.

  Yoko Nishimura, Motoki Matsuura, Noriko Terada, Sachiko Nagao, Hiroshi Shimada, Kyoko Isoyama, Masato Tamate, Masahiro Iwasaki, Tsuyoshi Saito

  BMC public health   23 ( 1 ) 473 - 473  2023.03  [International journal]

  　View Summary

  BACKGROUND: One cause of the increase in cervical cancer rates in Japan is the long-term stagnation in the cervical cancer screening consultation rate. Therefore, improving the screening consultation rate is of urgent concern to reduce cervical cancer incidence. Self-collected human papilloma virus (HPV) tests have been successfully adopted in several countries, such as the Netherlands and Australia, as a measure of individuals who have not undergone cervical cancer screening in national programs. This study aimed to verify whether self-collected HPV tests presented an effective countermeasure for individuals who had not undergone the recommended cervical cancer screenings. METHODS: This study was conducted from December 2020 to September 2022 in Muroran City, Japan. The primary evaluated endpoint was the percentage of citizens who underwent cervical cancer screening at a hospital with positive self-collected HPV test results. The secondary endpoint was the percentage of included participants who were diagnosed with cervical intraepithelial neoplasia (CIN) or higher among those who visited a hospital and underwent cervical cancer screening. RESULTS: The included study participants were 7,653 individuals aged 20-50 years with no record of previous cervical cancer examination in the past 5 years. We mailed these participants information on self-administered HPV tests as an alternative screening procedure and sent the kit to 1,674 women who requested the test. Among them, 953 returned the kit. Among the 89 HPV-positive individuals (positive rate, 9.3%), 71 (79.8%) visited the designated hospital for an examination. A closer examination revealed that 13 women (18.3% of hospital visits) had a CIN finding of CIN2 or higher, among whom one each had cervical cancer and vulvar cancer, eight presented with CIN3, and three presented with CIN2; two cases of invasive gynecologic cancer were also identified. CONCLUSIONS: We conclude that the self-collected HPV tests showed a certain efficacy as a measure of individuals who had not undergone the recommended cervical cancer screening. We devised ways to have the unexamined patients undergo HPV testing and ensure that HPV-positive individuals visited the hospital. Despite a few limitations, our findings suggest the effectiveness of this public health intervention.

  DOI PubMed

• 血中エクソソーム由来miRNAを用いた子宮頸癌の治療効果予測

  染谷 正則, 土屋 高旭, 福島 悠希, 長谷川 智一, 井戸川 雅史, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 鳥越 俊彦, 齋藤 豪, 坂田 耕一

  日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  60回   P102 - 2  2022.10

• Radiotherapy for HPV-related cancers: prediction of therapeutic effects based on the mechanism of tumor immunity and the application of immunoradiotherapy.

  Masanori Someya, Yuki Fukushima, Tomokazu Hasegawa, Takaaki Tsuchiya, Mio Kitagawa, Toshio Gocho, Shoh Mafune, Yutaro Ikeuchi, Yoh Kozuka, Yoshihiko Hirohashi, Toshihiko Torigoe, Masahiro Iwasaki, Motoki Matsuura, Tsuyoshi Saito, Koh-Ichi Sakata

  Japanese journal of radiology   40 ( 5 ) 458 - 465  2022.01  [Domestic journal]

  　View Summary

  Human papillomavirus (HPV)-related cancer is one of the diseases entities for which the applications of radiotherapy have been increasing. Recently, the process of carcinogenesis from HPV infection and the mechanism of tumor immunity that develops during disease progression have been elucidated. In this review, we will describe the mechanism of tumor immunity and how chemoradiotherapy may overcome and improve the efficacy of tumor immunity. We will also discuss the usefulness of proteins involved with tumor immunity as a predictive marker of radiotherapy response, and present an overview of ongoing clinical trials of combinations of immune checkpoint inhibitors and radiotherapy to demonstrate the promising combination therapy that has been currently emerging.

  DOI PubMed

• 術前補助化学療法後の子宮頸癌再発に対しheterogeneousな免疫逃避機構が関与している可能性 症例報告(Heterogenous Immune Escape Mechanisms Might be Related to Recurrence of Cervical Cancer after the Neoadjuvant Chemotherapy: A Case Report)

  常松 梨紗, 岩崎 雅宏, 廣橋 良彦, 阿部 秀悦, 小川 万梨絵, 郷久 晴朗, 西村 庸子, 玉手 雅人, 磯山 響子, 寺田 倫子, 松浦 基樹, 齋藤 豪

  日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   320 - 320  2021.07

• 深層学習を用いた子宮頸部細胞診人工知能診断支援システムの有用性について

  真里谷 奨, 南部 優太, 淺沼 広子, 廣橋 良彦, 岩崎 雅宏, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

  日本癌学会総会記事 ( (一社)日本癌学会 )  79回   OJ15 - 7  2020.10

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• 深層学習を用いた子宮頸部細胞診人工知能診断支援システムの有用性について

  真里谷 奨, 南部 優太, 淺沼 広子, 廣橋 良彦, 岩崎 雅宏, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

  日本癌学会総会記事 ( (一社)日本癌学会 )  79回   OJ15 - 7  2020.10

• マイクロサテライト不安定性およびHLAクラスI分子低発現の子宮内膜癌における臨床的意義(Clinical implications of microsatellite instability and HLA Class I downregulation in endometrial cancer)

  真里谷 奨, 廣橋 良彦, 玉手 雅人, 郷久 晴朗, 久保 輝文, 寺本 瑞絵, 岩崎 雅宏, 鳥越 俊彦, 齋藤 豪

  日本癌学会総会記事 ( (一社)日本癌学会 )  77回   518 - 518  2018.09

• A case of primary ovarian Granulocytic Sarcoma

  IKEDA Keiko, FUJIMOTO Takashi, SUZUKI Miwa, UMEMURA Kouta, IWASAKI Masahiro, SUZUKI Takahiro, ITOU Eiki, SAITO Tuyoshi

    28 ( 1 ) 77 - 81  2010.01

  CiNii

• Recurrent cervical cancer

  Japanese journal of clinical medicine   67   191 - 194  2009.08

  CiNii

• A case of carcinosarcoma of the ovary arising in endometriosis

  RYOSAKA Miwa, SAITO Tsuyoshi, NAGAI Miho, IWASAKI Masahiro, SUZUKI Takahiro, ITO Eiki, KUDO Ryuichi

    23 ( 1 ) 98 - 102  2005.01

  CiNii

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