Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2009

  -

  2011

  Sapporo Medical University   School of Medicine   講師

  講師

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Obstetrics and gynecology  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• ギャップ結合

• 子宮内膜

• パイスタンダー効果

• コネキシン

• ヘルペスウイルス

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• 【AIがもたらす婦人科癌医療の新展開】深層学習を利用したHE染色からの子宮内膜癌MMR status判定の可否に関する検討

  梅本 美菜, 真里谷 奨, 永田 舞, 堀米 俊弘, 新開 翔太, 杉田 真太朗, 金関 貴幸, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 長谷川 匡, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

  日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   153 - 153  2023.07

• 当院における婦人科癌に対するがん遺伝子パネル検査の現状と課題

  野藤 五沙, 真里谷 奨, 田中 佑弥, 室田 文子, 寺本 瑞絵, 松浦 基樹, 岩崎 雅宏, 石川 亜貴, 高田 弘一, 櫻井 晃洋, 齋藤 豪

  日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   288 - 288  2023.07

• 深層学習によるHE染色データを用いた子宮内膜癌プロファイル判定の適否に関する検討

  梅本 美菜, 真里谷 奨, 永田 舞, 堀米 俊弘, 新開 翔太, 杉田 真太朗, 金関 貴幸, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 長谷川 匡, 鳥越 俊彦, 齋藤 豪, 藤野 雄一

  日本医療情報学会春季学術大会プログラム・抄録集 ( (一社)日本医療情報学会 )  27回   122 - 123  2023.06

• 深層学習によるHE染色データを用いた子宮内膜癌プロファイル判定の適否に関する検討

  梅本 美菜, 真里谷 奨, 永田 舞, 堀米 俊弘, 新開 翔太, 杉田 真太朗, 金関 貴幸, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 長谷川 匡, 鳥越 俊彦, 齋藤 豪, 藤野 雄一

  日本医療情報学会春季学術大会プログラム・抄録集 ( (一社)日本医療情報学会 )  27回   122 - 123  2023.06

• Mailing human papillomavirus self-sampling kits to women under-screened for cervical cancer improved detection in cervical cancer screening in a general population study in Japan.

  Yoko Nishimura, Motoki Matsuura, Noriko Terada, Sachiko Nagao, Hiroshi Shimada, Kyoko Isoyama, Masato Tamate, Masahiro Iwasaki, Tsuyoshi Saito

  BMC public health   23 ( 1 ) 473 - 473  2023.03  [International journal]

  　View Summary

  BACKGROUND: One cause of the increase in cervical cancer rates in Japan is the long-term stagnation in the cervical cancer screening consultation rate. Therefore, improving the screening consultation rate is of urgent concern to reduce cervical cancer incidence. Self-collected human papilloma virus (HPV) tests have been successfully adopted in several countries, such as the Netherlands and Australia, as a measure of individuals who have not undergone cervical cancer screening in national programs. This study aimed to verify whether self-collected HPV tests presented an effective countermeasure for individuals who had not undergone the recommended cervical cancer screenings. METHODS: This study was conducted from December 2020 to September 2022 in Muroran City, Japan. The primary evaluated endpoint was the percentage of citizens who underwent cervical cancer screening at a hospital with positive self-collected HPV test results. The secondary endpoint was the percentage of included participants who were diagnosed with cervical intraepithelial neoplasia (CIN) or higher among those who visited a hospital and underwent cervical cancer screening. RESULTS: The included study participants were 7,653 individuals aged 20-50 years with no record of previous cervical cancer examination in the past 5 years. We mailed these participants information on self-administered HPV tests as an alternative screening procedure and sent the kit to 1,674 women who requested the test. Among them, 953 returned the kit. Among the 89 HPV-positive individuals (positive rate, 9.3%), 71 (79.8%) visited the designated hospital for an examination. A closer examination revealed that 13 women (18.3% of hospital visits) had a CIN finding of CIN2 or higher, among whom one each had cervical cancer and vulvar cancer, eight presented with CIN3, and three presented with CIN2; two cases of invasive gynecologic cancer were also identified. CONCLUSIONS: We conclude that the self-collected HPV tests showed a certain efficacy as a measure of individuals who had not undergone the recommended cervical cancer screening. We devised ways to have the unexamined patients undergo HPV testing and ensure that HPV-positive individuals visited the hospital. Despite a few limitations, our findings suggest the effectiveness of this public health intervention.

  DOI PubMed

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• 子宮体癌と大腸癌におけるミスマッチ修復タンパク欠損と免疫逃避機構の差異に関する検討

  真里谷 奨, 廣橋 良彦, 久保 輝文, 岩崎 雅宏, 鳥越 俊彦, 齋藤 豪

  日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   214 - 214  2021.07

• 深層学習を用いた子宮頸部細胞診人工知能診断支援システムの有用性について

  真里谷 奨, 南部 優太, 淺沼 広子, 廣橋 良彦, 岩崎 雅宏, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

  日本癌学会総会記事 ( (一社)日本癌学会 )  79回   OJ15 - 7  2020.10

• マイクロサテライト不安定性およびHLAクラスI分子低発現の子宮内膜癌における臨床的意義(Clinical implications of microsatellite instability and HLA Class I downregulation in endometrial cancer)

  真里谷 奨, 廣橋 良彦, 玉手 雅人, 郷久 晴朗, 久保 輝文, 寺本 瑞絵, 岩崎 雅宏, 鳥越 俊彦, 齋藤 豪

  日本癌学会総会記事 ( (一社)日本癌学会 )  77回   518 - 518  2018.09

• 腟式広汎性子宮頸部摘出術

  田中 綾一, 斉藤 豪, 鈴木 孝浩, 岩崎 雅宏, 梅村 康太, 松浦 基樹, 西川 鑑, 伊東 英樹

  日本婦人科腫瘍学会雑誌 = The journal of the Japan Society of Gynecologic Oncology   29 ( 3 ) 675 - 679  2011.06

  CiNii

• A case of primary ovarian Granulocytic Sarcoma

  IKEDA Keiko, FUJIMOTO Takashi, SUZUKI Miwa, UMEMURA Kouta, IWASAKI Masahiro, SUZUKI Takahiro, ITOU Eiki, SAITO Tuyoshi

  日本婦人科腫瘍学会雑誌 = The journal of the Japan Society of Gynecologic Oncology   28 ( 1 ) 77 - 81  2010.01

  CiNii

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses.

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2013.04

  -

  2016.03

   

  Saito Tsuyoshi, Iwasaki Masahiro, Tanaka Ryoichi, Sato Noriyuki

  　View Summary

  The aim of this study was to establish an efficient HPV type 16-targeting cancer immunotherapy. HPV16-derived viral proteins E6 and E7 are expressed in cancerous cells through the progression of the disease and have a role in carcinogenesis but are not expressed in normal cells. In this study, we generated a novel HPV 16 E6 and E7 gene plasmid containing oligomannose liposomes (OML-HPV). We compared the cytotoxic T lymphocyte (CTL) induction efficiency of OML-HPV and that of standard liposome-HPV16 E6 and E7 DNA complex. HPV16 E6-specific CTLs could be generated from HPV 16-positive cervical carcinoma patient's peripheral blood mononuclear cells by stimulating OML-HPV, but could not by stimulating standard liposome-HPV 16 E6, E7 DNA complex. These results indicate that OML-HPV is a more effective approach than DNA vaccination using standard liposomes, and that a novel HLA-A24-restricted peptide, E6 66-74, might be a suitable target of cervical cancer immunotherapy.

• Bistandar effect via gap junctional intercellular communication for gene-therapy in gynecologic cancers.

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2009

  -

  2011

   

  SAITO Tsuyoshi, SUZUKI Takahiro, IWASAKI Masahiro

  　View Summary

  We have confirmed bistandar effect via gap junctional intercellular communication in gynecologic cancers especially endometrial cancer cell. We have also found the bistandar effect was accelerated to add retinoids.