Biocompatibility Study of Hemoglobin Vesicles, Cellular-Type Artificial Oxygen Carriers, with Human Umbilical Cord Hematopoietic Stem/Progenitor Cells Using an In Vitro Expansion System Reviewed

Miki Yamaguchi, Mitsuhiro Fujihara, Shinobu Wakamoto, Hiromi Sakai, Shinji Takeoka, Eishun Tsuchida, Hirofumi Hamada, Hiroshi Azuma, Hisami Ikeda

ASAIO JOURNAL   55 ( 3 )   200 - 205   2009.5

Influence of hemoglobin vesicles, cellular-type artificial oxygen carriers, on human umbilical cord blood hematopoietic progenitor cells in vitro Reviewed

Miki Yamaguchi, Mitsuhiro Fujihara, Shinobu Wakamoto, Hiromi Sakai, Shinji Takeoka, Eishun Tsuchida, Hiroshi Azuma, Hisami Ikeda

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A   88A ( 1 )   34 - 42   2009.1

Generation of a considerable number of functional mast cells with a high basal level of Fc epsilon RI expression from cord blood CD34(+) cells by co-culturing them with bone marrow stromal cell line under serum-free conditions Reviewed

M. Yamaguchi, H. Azuma, M. Fujihara, H. Hamada, H. Ikeda

SCANDINAVIAN JOURNAL OF IMMUNOLOGY   65 ( 6 )   581 - 588   2007.6

Generation of inflammatory cytokines and chemokines from peripheral blood mononuclear cells by HLA Class II antibody-containing plasma unit that was associated with severe nonhemolytic transfusion reactions Reviewed

Hisako Sakagawa, Toru Miyazaki, Mitsuhiro Fujihara, Shinichiro Sato, Miki Yamaguchi, Kanji Fukai, Masanobu Morioka, Toshiaki Kato, Hiroshi Azuma, Hisami Ikeda

TRANSFUSION   47 ( 1 )   154 - 161   2007.1

Effects of hemoglobin vesicles, a liposomal artificial oxygen carrier, on hematological responses, complement and anaphylactic reactions in rats Reviewed

Hideki Abe, Hiroshi Azuma, Miki Yamaguchi, Mitsuhiro Fujihara, Hisami Ikeda, Hiromi Sakai, Shinji Takeoka, Eishun Tsuchida

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY   35 ( 2 )   157 - 172   2007

Effects of hemoglobin vesicles on resting and agonist-stimulated human platelets in vitro Reviewed

S Wakamoto, M Fujihara, H Abe, M Yamaguchi, H Azuma, H Ikeda, S Takeoka, E Tsuchida

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY   33 ( 2 )   101 - 111   2005

Cytotoxic difference of T cells expanded with anti-CD3 monoclonal antibody in the presence and absence of anti-CD28 monoclonal antibody Reviewed

Y Yamada-Ohnishi, H Azuma, N Urushibara, M Yamaguchi, M Fujihara, T Kobata, H Ikeda

STEM CELLS AND DEVELOPMENT   13 ( 3 )   315 - 322   2004.6

Thrombopoietin upregulates nucleolin mRNA and protein in thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO. Reviewed

Ito T, Fujihara M, Oda A, Wakamoto S, Yamaguchi M, Komatsu N, Miyazaki H, Azuma H, Ikeda H, Ikebuchi K

Mol Cell Biochem. 2003 May;247(1-2):75-82.   247 ( 1-2 )   75 - 82   2003.5

Possible contribution of apoptosis-inducing factor (AIF) and reactive oxygen species (ROS) to UVB-induced caspaseindependent cell death in the T cell line Jurkat Reviewed

H Murahashi, H Azuma, N Zamzami, KJ Furuya, K Ikebuchi, M Yamaguchi, Y Yamada, N Sato, M Fujihara, G Kroemer, H Ikeda

JOURNAL OF LEUKOCYTE BIOLOGY   73 ( 3 )   399 - 406   2003.3

Bone marrow stromal cells prepared using AB serum and bFGF for hematopoietic stem cells expansion Reviewed

M Yamaguchi, F Hirayama, S Wakamoto, M Fujihara, H Murahashi, N Sato, K Ikebuchi, K Sawada, T Koike, M Kuwabara, H Azuma, H Ikeda

TRANSFUSION   42 ( 7 )   921 - 927   2002.7

Functional evaluation of ex vivo expanded cord blood lymphocytes: Possible use for adoptive cellular immunotherapy Reviewed

H Azuma, Y Yamada, N Shibuya-Fujiwary, M Yamaguchi, H Murahashi, M Fujihara, N Sato, K Fukazawa, K Ikebuchi, H Ikeda

EXPERIMENTAL HEMATOLOGY   30 ( 4 )   346 - 351   2002.4

Ex vivo expansion of human UC blood primitive hematopoietic progenitors and transplantable stem cells using human primary BM stromal cells and human AB serum Reviewed

M Yamaguchi, F Hirayama, H Murahashi, H Azuma, N Sato, H Miyazaki, K Fukazawa, K Sawada, T Koike, M Kuwabara, H Ikeda, K Ikebuchi

CYTOTHERAPY   4 ( 2 )   109 - 118   2002.3

Inactivation of parvovirus B19 in coagulation factor concentrates by UVC radiation: assessment by an in vitro infectivity assay using CFU-E derived from peripheral blood CD34+cells Reviewed

H Sugawara, R Motokawa, H Abe, M Yamaguchi, Y Yamada-Ohnishi, J Hirayama, H Sakata, S Sato, N Kamo, K Ikebuchi, H Ikeda

TRANSFUSION   41 ( 4 )   456 - 461   2001.4

Serum-free coculture system for ex vivo expansion of human cord blood primitive progenitors and SCID mouse-reconstituting cells using human bone marrow primary stromal cells. Reviewed

Yamaguchi M, Hirayama F, Kanai M, Sato N, Fukazawa K, Yamashita K, Sawada K, Koike T, Kuwabara M, Ikeda H, Ikebuchi K

Exp Hematol. 2001 Feb;29(2):174-82.   29 ( 2 )   174 - 182   2001.2

Effects of poly(ethyleneglycol)-modified hemoglobin vesicles on N-formyl-methionyl-leucylphenylalanine-induced responses of polymorphonuclear neutrophils in vitro Reviewed

T Ito, M Fujihara, H Abe, M Yamaguchi, S Wakamoto, S Takeoka, H Sakai, E Tsuchida, H Ikeda, K Ikebuchi

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY   29 ( 6 )   427 - 437   2001

Comparison of sensitivity to ultraviolet B irradiation between human lymphocytes and hematopoietic stem cells. Reviewed

Azuma H, Ikebuchi K, Yamaguchi M, Murahashi H, Mogi Y, Sato N, Fujihara M, Hirayama F, Ikeda H

Blood. 2000 Oct 1;96(7):2632-4.   96 ( 7 )   2632 - 2634   2000.10

Stromal cell-independent differentiation of human cord blood CD34(+)CD38(-) lymphohematopoietic progenitors toward B cell lineage Reviewed

Y Yoshikawa, F Hirayama, M Kanai, S Nakajo, J Ohkawara, M Fujihara, M Yamaguchi, N Sato, M Kasai, S Sekiguchi, K Ikebuchi

LEUKEMIA   14 ( 4 )   727 - 734   2000.4

Role of physiologic concentrations of stem cell factor in leukemic type growth of myelodysplastic CD34+ cells. Reviewed

Sawada K, Koizumi K, Tarumi T, Takano H, Ieko M, Nishio M, Fukada Y, Yasukouchi T, Yamaguchi M, Koike T

Leuk Res.   23 ( 1 )   1 - 11   1999.1

A clonal culture assay for human cord blood lymphohematopoietic progenitors Reviewed

Y Yoshikawa, K Ikebuchi, J Ohkawara, F Hirayama, M Yamaguchi, N Sato, KJ Mori, M Kasai, S Sekiguchi

HUMAN IMMUNOLOGY   60 ( 1 )   75 - 82   1999.1

Large scale purification of human blood CD34(+) cells using a nylon-fiber syringe system and immunomagnetic microspheres Reviewed

K Koizumi, K Sawada, N Sato, M Yamaguchi, M Nishio, T Tarumi, H Takano, Y Fukada, M Ieko, T Yasukouchi, S Sekiguchi, T Koike

CYTOTHERAPY   1 ( 4 )   319 - 327   1999

Effects of liposome-encapsulated hemoglobin on phorbol ester-induced superoxide production and expression of costimulatory molecules by monocytes in vitro. Reviewed

Fujihara M, Ikebuchi K, Yamaguchi M, Abe H, Niwa K, Sekiguchi S

1998 Nov;26(5-6):487-95.   25 ( 5-6 )   487 - 495   1998.11

In vitro expansion of CD34(+)CD41(-) cells from human peripheral blood CD34(+)CD41(-) cells: Role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors Reviewed

K Koizumi, K Sawada, M Yamaguchi, A Notoya, T Tarumi, H Takano, Y Fukada, M Nishio, E Katagiri, T Yasukouchi, N Sato, S Sekiguchi, T Koike

EXPERIMENTAL HEMATOLOGY   26 ( 12 )   1140 - 1147   1998.11

Different adhesive characteristics and VLA-4 expression of CD34(+) progenitors in G(0)/G(1) versus S+G(2)/M phases of the cell cycle Reviewed

M Yamaguchi, K Ikebuchi, F Hirayama, N Sato, Y Mogi, J Ohkawara, Y Yoshikawa, K Sawada, T Koike, S Sekiguchi

BLOOD   92 ( 3 )   842 - 848   1998.8

Culture system for extensive production of CD19+IgM+ cells by human cord blood CD34+ progenitors. Reviewed

Ohkawara JI, Ikebuchi K, Fujihara M, Sato N, Hirayama F, Yamaguchi M, Mori KJ, Sekiguchi S.i

Leukemia. 1998 May;12(5):764-71.   12 ( 5 )   764 - 771   1998.5

Platelet-like particle production from cultured human megakaryocytic cell line Reviewed

K Ikebuchi, M Yamaguchi, K Niwa, H Abe, M Fujihara, S Sekiguchi

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY   26 ( 5-6 )   549 - 558   1998

Inflammatory cytokine production in whole blood modified by liposome-encapsulated hemoglobin Reviewed

K Niwa, K Ikebuchi, M Fujihara, H Abe, S Wakamoto, T Ito, M Yamaguchi, S Sekiguchi

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY   26 ( 5-6 )   559 - 570   1998

A rapid nylon-fiber syringe system to deplete CD14(+) cells for positive selection of human blood CD34(+) cells. Use of immunomagnetic microspheres Reviewed

M Yamaguchi, K Sawada, N Sato, K Koizumi, S Sekiguchi, T Koike

BONE MARROW TRANSPLANTATION   19 ( 4 )   373 - 379   1997.2

Role of cytokines in leukemic type growth of myelodysplastic CD34(+) cells Reviewed

K Sawada, M Ieko, A Notoya, T Tarumi, K Koizumi, S Kitayama, H Nishio, Y Fukada, T Yasukouchi, M Yamaguchi, S Katoh, T Koike

BLOOD   88 ( 1 )   319 - 327   1996.7

Proliferation and differentiation of myelodysplastic CD34+ cells in serum-free medium: II. Response to combined colony-stimulating factors. Reviewed

Sawada K, Sato N, Notoya A, Tarumi T, Yasukouchi T, Yamaguchi M, Kohno M, Mikuni C, Koike T

Eur J Haematol.   54 ( 2 )   85 - 94   1995.2

PROLIFERATION AND DIFFERENTIATION OF MYELODYSPLASTIC CD34(+) CELLS - PHENOTYPIC SUBPOPULATIONS OF MARROW CD34(+) CELLS Reviewed

K SAWADA, N SATO, A NOTOYA, T TARUMI, S HIRAYAMA, H TAKANO, K KOIZUMI, T YASUKOUCHI, M YAMAGUCHI, T KOIKE

BLOOD   85 ( 1 )   194 - 202   1995.1

TRANSITIONAL CHANGES IN IMMUNOPHENOTYPIC SUBPOPULATIONS OF HUMAN PERIPHERAL-BLOOD CD34(+) CELLS EXPANDED IN-VITRO Reviewed

K KOIZUMI, K SAWADA, N SATO, S HIRAYAMA, T YASUKOUCHI, M YAMAGUCHI, TA TAKAHASHI, S SEKIGUCHI, T KOIKE

EXPERIMENTAL HEMATOLOGY   22 ( 12 )   1171 - 1178   1994.11

IN-VITRO EXPANSION OF HUMAN PERIPHERAL-BLOOD CD34+ CELLS Reviewed

N SATO, K SAWADA, K KOIZUMI, T TARUMI, M IEKO, T YASUKOUCHI, M YAMAGUCHI, TA TAKAHASHI, S SEKIGUCHI, T KOIKE

BLOOD   82 ( 12 )   3600 - 3609   1993.12

Proliferation and differentiation of myelodysplastic CD34+ cells in serum-free medium: response to individual colony-stimulating factors. Reviewed

Sawada K, Sato N, Tarumi T, Sakai N, Koizumi K, Sakurama S, Ieko M, Yasukouchi T, Koyanagawa Y, Yamaguchi M

83 ( 3 )   348 - 358   1993.3

Bone marrow stromal cells prepared using AB serum and bFGF for hematopoietic stem cell expansion.

Transfusion.   42(7):921-7   2002

Functional evaluation of ex vivo expanded cord blood lymphocytes: possible use for adoptive cellular immunotherapy.

Exp Hematol.   30(4): 346-51.   2002

Ex vivo expansion of human cord blood primitive hematopoietic progenitors and transplantable stem cells using human primary bone marrow stromal cells and human AB serum.

Cytotherapy.   Vol.4(2) 109-18.   2002

Serum-free coculture system for ex vivo expansion of human cord blood primitive progenitors and SCID mouse-reconstituting cells using human bone marrow primary stromal cells.

Exp Hematol.   29(2):174-82.   2001

Effects of poly(ethyleneglycol)-modified hemoglobin vesicles on N-formyl-methionyl-leucyl-phenylalanine-induced responses of polymorphonuclear neutrophils in vitro.

Art if Cells Blood Substit Immobil Biotechnol.   29(6): 427-37.   2001

Inactivation of parvovirus B 19 in coagulation factor concentrates by UVC radiation: assessment by an in vitro nfectivity assay using CFU-E derived from peripheral blood CD34+ cells.

Transfusion.   41(4):456-61.   2001

Stromal cell-independent differentiation of human cord blood CD34+CD38- lymphohematopoietic progenitors toward B cell lineage.

Leukemia.   14(4) :727-34.   2000

Comparison of sensitivity to ultraviolet B irradiation between human lymphocytes and hematopoietic stem cells.

Blood.   96(7):2632-4.   2000

A clonal culture assay for human cord blood lymphohematopoietic progenitors.

Hum Immunol.   60(1):75-82.   1999

Cell cycle-dependent change of the adhesive character of CD34+ progenitor cells and their VLA-4 expression.

Rinsho Byori.   47(5):439-46 Review. Japanese.   1999

Role of physiologic concentrations of stem cell factor in leukemic type growth of myelodysplastic CD34+ cells.

Leuk Res.   23(1):1-11.   1999

Different adhesive characteristics and VLA-4 expression of CD34(+) progenitors in GO/Gi versus S+G2/M phases of the cell cycle.

Blood.   92(3):842-8]   1998

Inflammatory cytokine production in whole blood modified by liposome-encapsulated hemoglobin.

Artif Cells Blood Substit Immobil Biotechnol.   26(5-6):559-70.   1998

Platelet-like particle production from cultured human megakaryocytic cell line.

Art if Cells Blood Substit Immobil Biotechnol.   26(5-6):549-58   1998

n vitro expansion of CD34+/CD41+ cells from human peripheral blood CD34+/CD4L- cells: role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors.

Exp Hematol.   26(12):1140-7.   1998

Effects of liposome-encapsulated hemoglobin on phorbol ester-induced superoxide production and expression of molecules by monocytes in vitro.

Artif Cells Blood Substit Immobil Biotechnol.   26(5-6):487-95.   1998

A rapid nylon-fiber syringe system to deplete CD 14+ cells for positive selection of human blood CD34+ cells. Use of irnmunomagnetic microspheres.

Bone Marrow Transplant.   19(4): 373-9.   1997

Role of cytokines in leukemic type growth of myelodysplastic CD34+ cells.

Blood.   88(1):319-27.   1996

Proliferation and differentiation of myelodysplastic CD 34+ cells: phenotypic subpopulations of marrow CD34+ cells.

Blood.   85(1):194-202.   1995

Proliferation and differentiation of myelodysplastic CD34+ cells in serum-free medium: II. Response to combinedcolony-stimulating factors.

Eur J Haematol.   54(2):85-94.   1995

Transitional changes in immunophenotypic subpopulations of human peripheral blood CD34+ cells expanded in vitro.

Exp Hematol.   22(12):1171-8.   1994

Proliferation and differentiation of myelodysplastic CD 34+ cells in serum-free medium: response to individual colony-stimulating factors.

Br J Haematol.   83(3):349-58.   1993

In vitro expansion of human peripheral blood CD 34+ cells.

Blood.   15;82(12):3600-9.   1993

ex vivo expansion and characterization of EBV-specific CD4 positive bulk CTLs.

Japanese Journal of Transfusion Medicine   in press.