WATANABE Satoshi

写真a

Affiliation

School of Medicine, Department of Legal Medicine

Job title

Professor
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Education 【 display / non-display 】

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    1986

    Hokkaido University   School of Medicine   医学科  

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    1986

    Hokkaido University   Faculty of Medicine  

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Degree 【 display / non-display 】

  • (BLANK)

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Professional Memberships 【 display / non-display 】

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    日本膵臓学会

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    日本外科学会

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Research Areas 【 display / non-display 】

  • Life sciences   Anatomy  

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Affiliation 【 display / non-display 】

  • Former Institution / Organization Hokkaido University Graduate School of Medicine Division of Social Medicine   助手  

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Misc 【 display / non-display 】

  • Apoptosis and regeneration of pancreatic acinar cells

      29 ( 5 ) 13 - 18  1997

  • 膵腺房細胞のアポートシスと再生

    細胞   29 ( 5 ) 13 - 18  1997

  • APOPTOSIS OF MOUSE PANCREATIC ACINAR-CELLS AFTER DUCT LIGATION

    K ABE, S WATANABE

    ARCHIVES OF HISTOLOGY AND CYTOLOGY ( INT SOC HISTOLOGY & CYTOLOGY )  58 ( 2 ) 221 - 229  1995.06

    　View Summary

    It has been established that pancreatic exocrine acinar cells disappear after pancreatic duct obstruction. This study aimed to examine the relationship between the disappearance of the acinar cells and apoptosis after pancreatic duct ligation of the splenic lobe in dd-mice, six weeks of age. In some mice, the ligature was removed after two or three days. In addition to general light and electron microscopic examinations on the pancreatic tissues, paraffin sections stained with the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) method were observed to detect nuclear DNA fragmentation. Pancreatic acinar cells underwent apoptosis initiated with nuclear DNA damages three days after duct ligation and were completely deleted by seven days. Due to the elevation of the intraluminal pressure, the acinar cells showed interrupted secretion of their zymogen granules and disorganization of their rough endoplasmic reticulum, causing the cessation of granule formation before apoptosis started. These cytoplasmic changes prior to apoptosis are reversible, as observed after removal of the ligation. Apoptosis of the acinar cells was identified by TUNEL-labeling of the nuclei, the condensation and margination of nuclear chromatin, and round fragmentation of cell bodies, all irreversible changes. Apoptosis of acinar cells seemed to stimulate the proliferation of duct cells, which comprised the main cell components in the exocrine pancreas after the disappearance of acinar cells.

    DOI PubMed CiNii

  • Changes in the mouse exocrine pancreas after pancreatic duct ligation

    Archives of Histology and Cytology   58 ( 3 ) 365 - 374  1995

    DOI PubMed CiNii

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Research Projects 【 display / non-display 】

  • 膵臓外分泌部のアポトーシスと再生に関する研究

  • Study on Apoptosis and Regeneration of Exocrine Pancreas

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