Updated on 2025/08/22

写真a

 
MURASE Kazuyuki
 
Organization
School of Medicine Department of Medical Oncology Lecturer
Title
Lecturer
External link

Research Areas

  • Life Science / Tumor diagnostics and therapeutics

Professional Memberships

Papers

  • Efficacy of eribulin monotherapy for bone marrow carcinomatosis of breast cancer in a patient with Werner syndrome.

    Akihito Fujimi, Yasuhiro Nagamachi, Naofumi Yamauchi, Riku Hasebe, Naoki Onoyama, Naotaka Hayasaka, Teppei Matsuno, Kazuhiko Koike, Yoshiro Gotoh, Kohji Ihara, Junji Kato, Takuji Nishisato, Kazuyuki Murase, Goro Kutomi, Tokimasa Hida, Hisashi Uhara, Kohichi Takada

    Geriatrics & gerontology international   2025.1

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    Language：English  

    Various complications and potential risks of serious adverse events lessens the intensity of chemotherapy in patients with Werner syndrome. Bone marrow carcinomatosis of breast cancer was developed in a patient with Werner syndrome. Eribulin proved well tolerated and effective in improving severe thrombocytopenia, leading to platelet transfusion-free status.

    DOI： 10.1111/ggi.15070

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  • Establishment and characterization of the novel myxofibrosarcoma cell line, SMU-MFS

    Naoya Nakahashi, Makoto Emori, Kohichi Takada, Yasutaka Murahashi, Junya Shimizu, Kazuyuki Murase, Tomohide Tsukahara, Shintaro Sugita, Akira Takasawa, Kousuke Iba, Atsushi Teramoto, Makoto Osanai

    Human Cell   38 ( 1 )   2024.12

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Other Link： https://link.springer.com/article/10.1007/s13577-024-01157-9/fulltext.html

    DOI： 10.1007/s13577-024-01157-9

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  • Secondary Osteosarcoma After Carbon‐Ion Radiotherapy for Desmoid‐Type Fibromatosis: A Case Report

    Mizuki Aketo, Makoto Emori, Kohichi Takada, Kazuyuki Murase, Yohei Arihara, Junya Shimizu, Yasutaka Murahashi, Masahiko Okamoto, Shintaro Sugita, Atsushi Teramoto

    Cancer Reports   7 ( 11 )   2024.11

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    ABSTRACT

    Background

    Radiotherapy is considered an alternative treatment for unresectable or pharmacologically resistant desmoid‐type fibromatosis. While it results in relatively good local control, the risk of secondary malignancy remains a concern.

    Case

    We present a case of secondary osteosarcoma after carbon‐ion radiation therapy (CIRT). A 31‐year‐old male patient presented with left thigh pain. The tumor was located between the left gluteus maximus and gluteus medius and extended to the vastus lateralis and biceps femoris. It was diagnosed as desmoid‐type fibromatosis after needle biopsy. The patient was treated with several medications, including a cyclooxygenase 2 inhibitor and tamoxifen; however, his left thigh pain did not improve. He was treated with CIRT 1 year after diagnosis (67.2 Gy [relative biological effectiveness] 16fr/4wks). He developed osteosarcoma of the left femur 8 years later. He underwent chemotherapy and tumor excision with disarticulation of the left hip. Pulmonary metastasis was detected 6 and 17 months after the definitive surgery and excised using metastasectomy. However, he died due to the recurrence of multiple pulmonary metastases 29 months after the definitive surgery.

    Conclusions

    In this case, we believe that the low radiation dose to the femur may have caused secondary malignancy.

    DOI： 10.1002/cnr2.70062

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  • 切除不能または再発胆道癌に対するゲムシタビン/シスプラチン/S-1(GCS)療法とゲムシタビン/シスプラチン/デュルバルマブ(GCD)療法との比較検討

    吉田 真誠, 村松 丈児, 石川 和真, 高田 弘一, 村瀬 和幸, 大沼 啓之, 柾木 喜晴, 永島 裕之, 宮西 浩嗣

    胆道   38 ( 3 )   421 - 421   2024.9

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    Language：Japanese   Publisher：(一社)日本胆道学会  

    Ichushi

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  • LMNA::NTRK1 Fusion-positive Leiomyosarcoma: Discrepancy between DNA-based Comprehensive Genomic Profiling and RNA Sequencing. Reviewed

    Norito Suzuki, Masashi Idogawa, Makoto Emori, Kazuyuki Murase, Yohei Arihara, Hajime Nakamura, Makoto Usami, Tomohiro Kubo, Ichiro Kinoshita, Shintaro Sugita, Takashi Tokino, Tadashi Hasegawa, Akihiro Sakurai, Kohichi Takada

    Internal medicine (Tokyo, Japan)   63 ( 15 )   2215 - 2219   2024.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    A 26-year-old man presented with a tumor in the left soleus muscle. The tumor was diagnosed as a locally advanced leiomyosarcoma. The patient was treated with irradiation followed by wide resection. One year after surgery, the patient presented with multiple lung metastases. Despite aggressive sequential chemotherapy, systemic metastatic tumors continued to develop. To explore therapeutic options for the patient, we performed DNA-based CGP with FoundationOne® CDx (F1). F1 identified an out-of-strand rearrangement of the NOS1AP::NTRK1 gene, which has not been previously reported. In contrast, RNA sequencing revealed an in-frame LMNA::NTRK1 gene, which is an oncogenic fusion gene.

    DOI： 10.2169/internalmedicine.2879-23

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  • Marked Response to Nivolumab by a Patient With <scp>SMARCA4</scp>‐Deficient Undifferentiated Urothelial Carcinoma Showing High <scp>PD</scp>‐<scp>L1</scp> Expression: A Case Report

    Yohei Arihara, Ginji Omori, Ko Kobayashi, Shintaro Sugita, Kazuyuki Murase, Tomohiro Kubo, Masashi Idogawa, Tadashi Hasegawa, Kohichi Takada

    Cancer Reports   7 ( 6 )   2024.6

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    ABSTRACT

    Background

    SMARCA4 is a component gene of the SWI/SNF (SWItch/Sucrose NonFermentable) chromatin remodeling complex; undifferentiated tumors associated with its functional deletion have been described in several organs. However, no established treatment for these tumors currently exists.

    Case

    In this study, we report a case of a SMARCA4‐deficient undifferentiated urothelial carcinoma with high PD‐L1 expression that was effectively treated with nivolumab after early relapse following treatment for non‐invasive bladder cancer. The histological morphology of the rhabdoid‐like undifferentiated tumor of unknown primary led us to suspect a SWI/SNF‐deficient tumor, and subsequent immunostaining led to the diagnosis of a SMARCA4‐deficient undifferentiated tumor. This effort also led to the identification of the developmental origin of this SMARCA4‐deficient undifferentiated tumor as a non‐invasive bladder cancer. We also carried out a detailed immune phenotypic assay on peripheral T cells. In brief, a phenotypic change of CD8+T cells from naive to terminally differentiated effector memory cells was observed.

    Conclusion

    Regardless of the organ of cancer origin or cancer type, SWI/SNF‐deficient tumors should be suspected in undifferentiated and dedifferentiated tumors, and immune checkpoint inhibitors may be considered as a promising treatment option for this type of tumor. The pathogenesis of SMARCA4‐deficient anaplastic tumors awaits further elucidation for therapeutic development.

    DOI： 10.1002/cnr2.2127

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  • Notch signaling genes and CD8+ T-cell dynamics: Their contribution to immune-checkpoint inhibitor therapy in oral squamous cell carcinoma: A retrospective study. International journal

    Kazuhiro Ogi, Takahiro Iwamoto, Takashi Sasaya, Koyo Nishiyama, Takaaki Tokura, Takanori Sasaki, Hironari Dehari, Yohei Arihara, Kazuyuki Murase, Masato Saito, Masanori Someya, Kohichi Takada, Akihiro Miyazaki

    Cancer medicine   13 ( 5 )   e6985   2024.3

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    BACKGROUND: Aberrant Notch signaling pathway has been related with the tumorigenesis in head and neck region, involving oral cavity. Here, we report the correlation between mutations in the Notch signaling pathway and CD8+ T-cell infiltration via PD-L1, which lead to enhanced antitumor immunity and may target for immune-checkpoint inhibitors (ICIs) therapy. METHODS: This retrospective study analyzed the results of immunohistochemical staining for PD-L1 and CD8+ T-cell infiltration in 10 patients and whole-exome sequencing (WES) was conducted on five of these patients to identify frequently mutated genes. RESULTS: Four of 10 patients were positive for PD-L1 and CD8+ T. By analyzing WES in three of these four patients, we notably identified the mutations of NOTCH1, FBXW7, and noncoding RNA intronic mutation in NOTCH2NLR in two of these three patients. This study may enable better selection of ICI therapy with CD8+ T-cell infiltration via PD-L1 expression for oral squamous cell carcinoma patients with mutations in Notch signaling pathway.

    DOI： 10.1002/cam4.6985

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  • Stage IVa進行食道癌におけるDocetaxel/CDGP/5-FU・放射線同時併用療法(DNF-R)の予後解析

    佐藤 昌則, 大沼 啓之, 早坂 尚貴, 濱口 孝太, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 加藤 淳二, 染谷 正則, 坂田 耕一

    北海道医学雑誌   98 ( 2 )   139 - 139   2023.11

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    Language：Japanese   Publisher：北海道医学会  

    Ichushi

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  • Coefficient of variation of T2-weighted MRI may predict the prognosis of malignant peripheral nerve sheath tumor. International journal

    Makoto Emori, Hiroyuki Tsuchie, Hiroyuki Takashima, Atsushi Teramoto, Yasutaka Murahashi, Yoshinori Imura, Hidetatsu Outani, Sho Nakai, Satoshi Takenaka, Ryosuke Hirota, Naoya Nakahashi, Junya Shimizu, Kazuyuki Murase, Akira Takasawa, Hiroyuki Nagasawa, Shintaro Sugita, Kohichi Takada, Tadashi Hasegawa, Seiji Okada, Naohisa Miyakoshi, Toshihiko Yamashita

    Skeletal radiology   2023.9

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    BACKGROUND: We investigated whether non-enhancement MRI features, including measurement of the heterogeneity of the tumor with MR T2 imaging by calculating coefficient of variation (CV) values, were associated with the prognosis of non-metastatic malignant peripheral nerve sheath tumors (MPNST). METHODS: This retrospective study included 42 patients with MPNST who had undergone surgical resection (mean age, 50 years ± 21; 20 male participants). Non-enhancement MR images were evaluated for signal intensity heterogeneity on T1- and T2-weighted imaging, tumor margin definition on T1- and T2-weighted imaging, peritumoral edema on T2-weight imaging, and CV. We measured the signal intensities of MR T2-weighted images and calculated the corresponding CV values. CV is defined as the ratio of the standard deviation to the mean. The associations between factors and overall survival (OS) were investigated via the Kaplan-Meier method with log-rank tests and the Cox proportional hazards model. RESULTS: The mean CV value of MR T2 images was 0.2299 ± 0.1339 (standard deviation) (range, 0.0381-0.8053). Applying receiver operating characteristics analysis, the optimal cut-off level for CV value was 0.137. This cut-off CV value was used for its stratification into high and low CV values. At multivariate survival analysis, a high CV value (hazard ratio = 3.63; 95% confidence interval = 1.16-16.0; p = 0.047) was identified as an independent predictor of OS. CONCLUSION: The CV value of the signal intensity of heterogenous MPNSTs MR T2-weighted images is an independent predictor of patients' OS.

    DOI： 10.1007/s00256-023-04457-7

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  • 胆道癌に対して経皮経肝門脈塞栓術施行後に非切除であった症例の検討

    村松 丈児, 石川 和真, 吉田 真誠, 大沼 啓之, 村瀬 和幸, 高田 弘一, 柾木 喜晴, 齊藤 正人, 今村 将史, 宮西 浩嗣

    日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集   133回・127回   42 - 42   2023.9

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    Language：Japanese   Publisher：日本消化器病学会-北海道支部  

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  • 術前補助療法施行後の切除可能膵癌における術後早期再発予測因子の解析

    齊藤 聖也, 吉田 真誠, 村松 丈児, 石川 和真, 柾木 喜晴, 木村 康利, 今村 将史, 久保 智洋, 村瀬 和幸, 大沼 啓之, 高田 弘一, 宮西 浩嗣, 加藤 淳二

    膵臓   38 ( 3 )   A446 - A446   2023.7

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    Language：Japanese   Publisher：(一社)日本膵臓学会  

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  • Synergistic antitumor effect of histone deacetylase class IIa inhibitor with lenvatinib in hepatocellular carcinoma. International journal

    Ryo Ito, Koji Miyanishi, Tomohiro Kubo, Kota Hamaguchi, Takahiro Osuga, Shingo Tanaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, Yasutoshi Kimura, Toru Mizuguchi, Ichiro Takemasa, Junji Kato

    Hepatology international   17 ( 3 )   735 - 744   2023.6

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    BACKGROUND: Histone deacetylase (HDAC) class I and IIa are highly expressed in hepatocellular carcinoma (HCC) and associated with decreased survival. However, clinically used pan and class I inhibitors have serious adverse events. In this study, we assessed the antitumor effects and tolerability of class IIa HDAC inhibitor (HDACI) with lenvatinib, which is a standard therapy for HCC. METHODS AND RESULT: Combination therapy with class IIa HDACI and lenvatinib exerted synergistic antitumor effect in human HCC cell lines. In mouse models, this therapy showed significant antitumor effects, and few adverse events occurred. In immunoblotting, the expression of fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) was high in cell lines that showed a high antitumor effect. In addition, class IIa HDACI administration decreased the expression of FGFR4. In the small interfering RNA (siRNA) analysis, knockdown of HDAC9, which is an isoform of HDAC class IIa, reduced the expression of FGFR4 and induced apoptosis. Immunohistochemistry of human clinical specimens showed a positivity rate of 32% for FGFR4 and 84% for HDAC9 in HCC, and all FGFR4-positive patients were HDAC9 positive. CONCLUSION: Class IIa HDACI and lenvatinib combination therapy induces apoptosis by downregulating FGFR4 and blocking the FGFR signaling in FGFR4-positive HCC cell lines and has demonstrated synergistic antitumor effects and safety. This combination therapy overcomes the problems of conventional therapies and will be beneficial for FGFR4-positive HCC patients.

    DOI： 10.1007/s12072-023-10484-2

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  • Drastic Multiorgan Dysfunction Due to Severe Leukostasis: A Case Report. International journal

    Akinori Tada, Yasuhiro Kikuchi, Kazuyuki Murase, Kohichi Takada, Akira Takasawa

    Cureus   14 ( 11 )   e31518   2022.11

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    Leukostasis is a life-threatening complication that causes vascular occlusion leading to organ damage in leukemia patients. Organs with impairment due to leukostasis are usually the lungs and kidneys, but other organs may also be damaged. We experienced an autopsy case of severe infarction in multiple organs including the spleen probably due to leukostasis in a patient with acute myeloid leukemia.

    DOI： 10.7759/cureus.31518

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  • 食道癌化学放射線療法症例における放射線胃炎のリスク因子の検討

    佐藤 昌則, 大沼 啓之, 早坂 尚貴, 伊藤 亮, 村瀬 和幸, 高田 弘一, 福島 悠希, 長谷川 智一, 土屋 高旭, 染谷 正則, 宮西 浩嗣, 坂田 耕一, 加藤 淳二

    日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集   131回・125回   55 - 55   2022.9

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    Language：Japanese   Publisher：日本消化器病学会-北海道支部  

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  • 食道癌化学放射線療法症例における放射線胃炎のリスク因子の検討

    佐藤 昌則, 大沼 啓之, 早坂 尚貴, 伊藤 亮, 村瀬 和幸, 高田 弘一, 福島 悠希, 長谷川 智一, 土屋 高旭, 染谷 正則, 宮西 浩嗣, 坂田 耕一, 加藤 淳二

    日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集   131回・125回   55 - 55   2022.9

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  • 表在型食道癌ESD後のMM-SM癌における追加化学放射線療法の長期成績

    伊藤 亮, 大沼 啓之, 早坂 尚貴, 佐藤 昌則, 村瀬 和幸, 高田 弘一, 福島 悠希, 長谷川 智一, 土屋 高旭, 染谷 正則, 宮西 浩嗣, 坂田 耕一, 加藤 淳二

    日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集   131回・125回   56 - 56   2022.9

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  • 表在型食道癌ESD後のMM-SM癌における追加化学放射線療法の長期成績

    伊藤 亮, 大沼 啓之, 早坂 尚貴, 佐藤 昌則, 村瀬 和幸, 高田 弘一, 福島 悠希, 長谷川 智一, 土屋 高旭, 染谷 正則, 宮西 浩嗣, 坂田 耕一, 加藤 淳二

    日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集   131回・125回   56 - 56   2022.9

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  • Association between Hepatic Oxidative Stress Related Factors and Activation of Wnt/β-Catenin Signaling in NAFLD-Induced Hepatocellular Carcinoma. International journal

    Kota Hamaguchi, Koji Miyanishi, Takahiro Osuga, Shingo Tanaka, Ryo Ito, Hiroki Sakamoto, Tomohiro Kubo, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, Yasutoshi Kimura, Toru Mizuguchi, Ichiro Takemasa, Junji Kato

    Cancers   14 ( 9 )   2022.4

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    We investigated the association between iron overload, oxidative stress (8-oxo-7,8-dihydroguanine: 8-oxo-dG scores), Wnt/β-catenin pathway activation (expression of glutamine synthetase: GS), and tumor hyperintensity in the Gd-EOB-DTPA-enhanced MRI hepatobiliary phase (relative enhancement ratio: RER). This was a retrospective analysis of 94 hepatocellular carcinoma (HCC) patients who underwent surgical resection. In HBV-, HCV-, and alcohol-associated HCC, serum ferritin levels in the high and low RER groups were equivalent. In contrast, ferritin levels were elevated in the 'high RER' group of patients with nonalcoholic fatty liver disease (NAFLD)-HCC. As predictors of GS positivity, high RER had a sensitivity of 57.2% and a specificity of 100%. High serum ferritin had a sensitivity of 85.7% and a specificity of 85.7%. All cases with serum ferritin ≥275.5 ng/mL and high RER were 8-oxo-dG- and iron staining-positive. Additionally, GS positivity was seen in all cases with "serum ferritin levels above the upper limits or iron staining-positive" and '8-oxo-dG high' cases. Therefore, combining serum ferritin levels with RER may increase the accuracy with which activated Wnt/β-catenin signaling is predicted in NAFLD-HCC. We suggest that 8-oxo-dG accumulates following increased oxidative stress due to hepatic tissue iron deposition; this may activate Wnt/β-catenin signaling and trigger carcinogenesis.

    DOI： 10.3390/cancers14092066

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  • A case of acute exacerbation of chronic hepatitis C during the course of adrenal Cushing's syndrome

    Takahiro Osuga, Koji Miyanishi, Kota Hamaguchi, Shingo Tanaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Junji Kato

    Clinical Case Reports   10 ( 2 )   2022.2

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.5337

    DOI： 10.1002/ccr3.5337

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  • Achievement of a durable response with eribulin for relapsed cardiac metastasis of uterine leiomyosarcoma after surgery: a case report and literature review

    Makoto Usami, Kohichi Takada, Hajime Nakamura, Kazuyuki Murase, Yohei Arihara, Naotaka Hayasaka, Tomohiro Kubo, Koji Miyanishi, Junji Kato, Makoto Emori, Shintaro Sugita

    Annals of Palliative Medicine   2022.1

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    Publishing type：Research paper (scientific journal)   Publisher：AME Publishing Company  

    DOI： 10.21037/apm-22-536

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  • A Case of Unresectable Combined Hepatocellular-Cholangiocarcinoma Successfully Treated with Lenvatinib. International journal

    Takahiro Osuga, Koji Miyanishi, Ryo Ito, Shingo Tanaka, Kota Hamaguchi, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, Yasutoshi Kimura, Taro Sugawara, Shintaro Sugita, Ichiro Takemasa, Tadashi Hasegawa, Junji Kato

    Case reports in oncology   15 ( 1 )   318 - 325   2022

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    A 77-year-old man was referred to our hospital because of a hepatic tumor. Blood biochemistry showed elevated serum alfa-fetoprotein, protein induced by vitamin K absence-II, and carbohydrate antigen 19-9 levels. Gd-EOB-DTPA-enhanced magnetic resonance imaging revealed a 95-mm-sized tumor in liver S7. The tumor showed heterogeneous hyperintensity in the arterial phase, slightly washed out from the portal vein phase, and hypointensity in the hepatocellular phase. Post-enlargement segmental resection was performed, and the pathological diagnosis was combined hepatocellular cholangiocarcinoma. Seven months after surgery, multiple liver tumors were found, and biopsy revealed combined hepatocellular-cholangiocarcinoma. Hepatic arterial infusion chemotherapy with cisplatin was initiated. However, the patient developed a pulmonary abscess, which was treated with antibiotics. He then underwent treatment with lenvatinib, 11 months after surgery. At 8 weeks follow-up, a complete response (according to the modified Response Evaluation Criteria in Solid Tumors [RECIST]) and a partial response (RECIST version 1.1) was noted. To the best of our knowledge, thus far, only a single case of lenvatinib treatment of unresectable mixed liver cancer has been reported. In that case, lenvatinib was used as a third-line treatment. The present report is the first to describe lenvatinib as a first-line therapy for unresectable combined hepatocellular-cholangiocarcinoma, which resulted in a meaningful response. This case provides useful insights into the choice of appropriate drug treatment in this disease in the absence of randomized controlled trials of drug treatment.

    DOI： 10.1159/000523895

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  • MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model

    Hiroki Sakamoto, Koji Miyanishi, Shingo Tanaka, Ryo Ito, Kota Hamaguchi, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yusaku Nakabeppu, Masayoshi Kobune, Junji Kato

    Scientific Reports   11 ( 1 )   2021.12

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    <title>Abstract</title>Non-alcoholic steatohepatitis (NASH)-related HCC is associated with oxidative stress. However, the mechanisms underlying the development of NASH-related HCC is unclear. MUTYH is one of the enzymes that is involved in repair of oxidative DNA damage. The aim of this study was to investigate the association between MUTYH and NASH-related hepatocarcinogenesis. MUTYH wild-type (<italic>Mutyh</italic><sup>+/+</sup>), heterozygous (<italic>Mutyh</italic><sup>+/−</sup>), and MUTYH-null (<italic>Mutyh</italic><sup>−/−</sup>) mice were fed a high-fat high-cholesterol (HFHC) diet or HFHC + high iron diet (20 mice per group) for 9 months. Five of 20 <italic>Mutyh</italic><sup>−/−</sup> mice fed an HFHC + high iron diet developed liver tumors, and they developed more liver tumors than other groups (especially vs. Mutyh<sup>+/+</sup> fed an HFHC diet, <italic>P</italic> = 0.0168). Immunohistochemical analysis revealed significantly higher accumulation of oxidative stress markers in mice fed an HFHC + high iron diet. The gene expression profiles in the non-tumorous hepatic tissues were compared between wild-type mice that developed no liver tumors and MUTYH-null mice that developed liver tumors. Gene Set Enrichment Analysis identified the involvement of the Wnt/β-catenin signaling pathway and increased expression of <italic>c-Myc</italic> in MUTYH-null liver. These findings suggest that MUTYH deficiency is associated with hepatocarcinogenesis in patients with NASH with hepatic iron accumulation.

    Other Link： http://www.nature.com/articles/s41598-021-83138-8

    DOI： 10.1038/s41598-021-83138-8

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  • Combination of psoas muscle mass index and neutrophil/lymphocyte ratio as a prognostic predictor for patients undergoing nonsurgical hepatocellular carcinoma therapy

    Yusuke Sugama, Koji Miyanishi, Takahiro Osuga, Shingo Tanaka, Kota Hamaguchi, Ryo Ito, Hiroki Sakamoto, Tomohiro Kubo, Hiroyuki Ohnuma, Kazuyuki Murase, Kohich Takada, Masayoshi Kobune, Junji Kato

    JGH Open   5 ( 12 )   1335 - 1343   2021.12

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jgh3.12676

    DOI： 10.1002/jgh3.12676

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  • Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma: A Case Report.

    Joji Muramatsu, Kohichi Takada, Shintaro Sugita, Takaaki Tsuchiya, Keisuke Yamamoto, Masaru Takagi, Kazuyuki Murase, Saki Ameda, Yohei Arihara, Koji Miyanishi, Koh-Ichi Sakata, Junji Kato

    Internal medicine (Tokyo, Japan)   2021.10

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    An 18-year-old man presented with sudden vision loss in his left eye. Magnetic resonance imaging revealed a tumor that had invaded the left optic nerve, originating from the left posterior ethmoid sinus. Immunohistochemical analyses identified positive staining for NUT protein in the nuclei of tumor cells. We diagnosed locally advanced NUT carcinoma (NC) and initiated concurrent chemoradiotherapy (CCRT), consisting of chemotherapy with vincristine, doxorubicin, and cyclophosphamide, alternating with ifosphamide and etoposide, plus radiation therapy. The patient achieved a complete response. CCRT can be a useful treatment option for adolescent and young-adult patients with locally advanced unresectable NC.

    DOI： 10.2169/internalmedicine.7741-21

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  • 進行食道癌に対するdocetaxel、nedaplatin、5-fluorouracil、放射線併用療法(DNF-R)による根治的化学放射線療法の第I/II相試験-アップデート解析

    佐藤 昌則, 大沼 啓之, 早坂 尚貴, 濱口 孝太, 村瀬 和幸, 高田 弘一, 福島 悠希, 長谷川 智一, 土屋 高旭, 染谷 正則, 宮西 浩嗣, 坂田 耕一, 加藤 淳二

    日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集   129回・123回   26 - 26   2021.9

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  • Programmed cell death ligand 1 expression in a case of poorly differentiated lymphocyte‐rich hepatocellular carcinoma

    Ginji Omori, Takahiro Osuga, Koji Miyanishi, Kota Hamaguchi, Shingo Tanaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, Yasutoshi Kimura, Ichiro Takemasa, Yasuhiro Kikuchi, Toshihiko Torigoe, Junji Kato

    Clinical Case Reports   9 ( 9 )   2021.9

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.4764

    DOI： 10.1002/ccr3.4764

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  • 血液疾患患者におけるCOVID-19感染症4例の報告(Four cases of COVID-19 patients with hematological malignancy)

    小野 賢人, 堀口 拓人, 下山 紗央莉, 藤田 千紗, 後藤 亜香利, 池田 博, 井山 諭, 村瀬 和幸, 高田 弘一, 藤谷 好弘, 高橋 聡, 黒沼 幸治, 小船 雅義

    日本血液学会学術集会   83回   OS3 - 4   2021.9

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  • Survival benefit of conversion surgery after intensive chemotherapy for unresectable metastatic gastric cancer: a propensity score-matching analysis

    Hiroyuki Ohnuma, Yasushi Sato, Naoki Onoyama, Kota Hamaguchi, Naotaka Hayasaka, Masanori Sato, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Takeshi Murakami, Tatsuya Ito, Takayuki Nobuoka, Ichiro Takemasa, Junji Kato

    Journal of Cancer Research and Clinical Oncology   147 ( 8 )   2385 - 2396   2021.8

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Other Link： https://link.springer.com/article/10.1007/s00432-021-03516-7/fulltext.html

    DOI： 10.1007/s00432-021-03516-7

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  • Eribulin in combination with HER2-targeted antibodies for successful treatment of metastatic salivary duct carcinoma: A report of two cases

    Akihito Fujimi, Yasuhiro Nagamachi, Naofumi Yamauchi, Takuji Nishisato, Kazuyuki Murase, Kohichi Takada, Mitsuhiro Tsujiwaki, Shintaro Sugita, Tadashi Hasegawa, Junji Kato

    Oral Oncology   105287 - 105287   2021.4

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.oraloncology.2021.105287

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  • A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis. International journal

    Taro Murakami, Akira Takasawa, Asako Moriki, Yusuke Igaki, Hiroshi Ikeda, Kazuyuki Murase, Kohichi Takada, Kazufumi Magara, Tomoyuki Aoyama, Yusuke Ono, Daisuke Kyuno, Kumi Takasawa, Masaki Murata, Makoto Osanai

    Virchows Archiv : an international journal of pathology   2021.3

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    Amyloidosis is induced by extracellular deposition of certain proteins. Thirty-six proteins have so far been identified as amyloidogenic proteins in humans. Although it is very important to determine the specific amyloid protein type for the choice of therapy for amyloidosis patient, it might be difficult to identify specific proteins from amyloid-deposited tissue. Apolipoprotein A-IV is known as an amyloid-associated protein, but there have been few reports of apolipoprotein A-IV amyloidosis. Here we report a case of systemic apolipoprotein A-IV-associated amyloidosis that was confirmed by proteome analysis using formalin-fixed paraffin-embedded tissue and an immunohistochemical technique.

    DOI： 10.1007/s00428-021-03073-x

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  • 食道癌 診断と治療のup to date 食道腺癌を含めて 切除可能進行食道癌に対する三剤併用療法ベースの化学放射線療法は手術療法を代替できるか?:傾向スコアマッチング分析

    大沼 啓之, 小野山 直輝, 濱口 孝太, 早坂 尚貴, 佐藤 昌則, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 村上 武志, 伊東 竜哉, 信岡 隆幸, 竹政 伊知朗, 土屋 高旭, 長谷川 智一, 堀 正和, 染谷 正則, 坂田 耕一, 加藤 淳二

    日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集   128回・122回   35 - 35   2021.3

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  • 食道癌 診断と治療のup to date 食道腺癌を含めて 切除可能進行食道癌に対する三剤併用療法ベースの化学放射線療法は手術療法を代替できるか?:傾向スコアマッチング分析

    大沼 啓之, 小野山 直輝, 濱口 孝太, 早坂 尚貴, 佐藤 昌則, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 村上 武志, 伊東 竜哉, 信岡 隆幸, 竹政 伊知朗, 土屋 高旭, 長谷川 智一, 堀 正和, 染谷 正則, 坂田 耕一, 加藤 淳二

    日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集   128回・122回   35 - 35   2021.3

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  • A case of hypervascular tumors in the liver and pancreas: synchronous hepatocellular carcinoma and pancreatic metastasis from renal cell carcinoma 36 years after nephrectomy

    Hajime Nakamura, Shingo Tanaka, Koji Miyanishi, Yutaka Kawano, Takahiro Osuga, Kazuma Ishikawa, Makoto Yoshida, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Hiroshi Yamaguchi, Minoru Nagayama, Yasutoshi Kimura, Ichiro Takemasa, Junji Kato

    Clinical Case Reports   9 ( 2 )   932 - 937   2021.2

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.3691

    DOI： 10.1002/ccr3.3691

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  • Successful mycophenolate mofetil treatment of a patient with severe steroid‐refractory hepatitis evoked by nivolumab plus ipilimumab treatment for relapsed bladder cancer

    Ginji Omori, Kohichi Takada, Kazuyuki Murase, Naotaka Hayasaka, Hajime Nakamura, Satoshi Iyama, Hiroyuki Ohnuma, Koji Miyanishi, Fumimasa Fukuta, Toshiaki Tanaka, Naoya Masumori, Junji Kato

    Clinical Case Reports   9 ( 2 )   654 - 659   2021.2

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.3597

    DOI： 10.1002/ccr3.3597

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  • Case series of three patients with hereditary diffuse gastric cancer in a single family: Three case reports and review of literature

    Masahiro Hirakawa, Kohichi Takada, Masanori Sato, Chisa Fujita, Naotaka Hayasaka, Takayuki Nobuoka, Shintaro Sugita, Aki Ishikawa, Miyako Mizukami, Hiroyuki Ohnuma, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Ichiro Takemasa, Tadashi Hasegawa, Akihiro Sakurai, Junji Kato

    World Journal of Gastroenterology   26 ( 42 )   6689 - 6697   2020.11

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    Publishing type：Research paper (scientific journal)   Publisher：Baishideng Publishing Group Inc.  

    DOI： 10.3748/wjg.v26.i42.6689

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  • Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer

    Hajime Nakamura, Kohichi Takada, Kazuyuki Murase, Hiroki Sakamoto, Naotaka Hayasaka, Kazuma Ishikawa, Yuki Ikeda, Makoto Yoshida, Satoshi Iyama, Ko Kobayashi, Tetsuya Shindo, Shintaro Sugita, Koji Miyanishi, Masayoshi Kobune, Naoya Masumori, Junji Kato

    Case Reports in Oncological Medicine   2020   1 - 4   2020.11

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    Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

    Papillary thyroid cancer (PTC) is considered an indolent cancer, but some PTC patients do present with distant metastases and treatment strategies for such patients are not well established. Recently, lenvatinib, an inhibitor of multiple tyrosine kinases, has been introduced to treat patients with advanced PTC but carries a risk of serious adverse events such as hemorrhage. Here, we report a PTC patient with a left adrenal metastasis and lenvatinib-induced hemorrhage who underwent successful surgical resection and was subsequently treated with a lower dose of lenvatinib. The patient has now been in a stable state with no adverse events for nearly two years. This case highlights the importance of surgical resection of metastatic PTC and subsequent lenvatinib therapy, even when the tumor is at an advanced stage.

    Other Link： http://downloads.hindawi.com/journals/crionm/2020/2107430.xml

    DOI： 10.1155/2020/2107430

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  • Two cases of synchronous multicentric invasive ductal carcinomas of the pancreas

    Yuki Ikeda, Makoto Yoshida, Kazuma Ishikawa, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Ichiro Takemasa, Tadashi Hasegawa, Junji Kato

    Gastroenterological Endoscopy   62 ( 7 )   785 - 792   2020.7

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    DOI： 10.11280/gee.62.785

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  • 粘液癌成分を伴った浸潤性膵管癌破裂の1切除例

    久保 智洋, 村松 丈児, 吉田 真誠, 木内 隆之, 杉田 真太朗, 奥田 敏徳, 南 伸弥, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 長谷川 匡, 加藤 淳二

    膵臓   35 ( 3 )   A437 - A437   2020.7

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  • Pancreatic cancer with leptomeningeal carcinomatosis: case report and literature review

    Yuki Ikeda, Makoto Yoshida, Kazuma Ishikawa, Tomohiro Kubo, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Junji Kato

    International Cancer Conference Journal   9 ( 2 )   96 - 100   2020.4

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Other Link： http://link.springer.com/article/10.1007/s13691-020-00405-7/fulltext.html

    DOI： 10.1007/s13691-020-00405-7

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  • Blastic plasmacytoid dendritic cell neoplasm(BPDCN)の2例

    執行 延明, 西田 彩華, 菅野 莉英, 藤岡 茉生, 大橋 隆宏, 堀本 浩平, 加藤 潤史, 肥田 時征, 宇原 久, 村瀬 和幸, 井山 諭, 須釜 佑介, 前田 和男

    日本皮膚科学会雑誌   130 ( 3 )   418 - 418   2020.3

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  • 切除可能進行食道癌に対する三剤併用療法ベースの化学放射線療法は手術療法を代替できるか? 傾向スコアマッチング分析

    大沼 啓之, 小野山 直輝, 濱口 孝太, 早坂 尚貴, 佐藤 昌則, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 伊東 竜哉, 信岡 隆幸, 竹政 伊知朗, 長谷川 智一, 堀 正和, 染谷 正則, 坂田 耕一, 加藤 淳二

    日本消化器病学会北海道支部例会プログラム・抄録集   126回   50 - 50   2020.3

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  • Pulmonary metastasectomy is associated with prolonged survival among patients with bone and soft tissue sarcoma

    Junya Shimizu, Makoto Emori, Yasutaka Murahashi, Tomoko Sonoda, Taijiro Mishina, Masahiro Miyajima, Atsushi Watanabe, Shintaro Sugita, Kohichi Takada, Kazuyuki Murase, Tadashi Hasegawa, Toshihiko Yamashita

    Molecular and Clinical Oncology   2020.2

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    Publishing type：Research paper (scientific journal)   Publisher：Spandidos Publications  

    DOI： 10.3892/mco.2020.2009

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  • Efficacy of combination therapy with dexmedetomidine for benzodiazepines-induced disinhibition during endoscopic retrograde cholangiopancreatography

    Yuki Ikeda, Makoto Yoshida, Kazuma Ishikawa, Tomohiro Kubo, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Therapeutic Advances in Gastroenterology   13   175628482091182 - 175628482091182   2020.1

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    Publishing type：Research paper (scientific journal)   Publisher：SAGE Publications  

    <sec><title>Background:</title> Benzodiazepines (BZDs) and analgesics are widely used for conscious sedation during endoscopic ultrasound (EUS) or endoscopic retrograde cholangiopancreatography (ERCP). However, endoscopic procedures are sometimes discontinued because of BZD-induced disinhibitory reactions such as excessive movement. We evaluated the usefulness of dexmedetomidine (DEX) for BZD-induced disinhibition in ERCP.

    </sec><sec><title>Methods:</title> Between February 2018 and August 2019, 22 patients who underwent EUS or ERCP were enrolled. All patients showed BZD-induced excessive movement at the first examination (BZD group) and received DEX at the second examination (DEX group). The initial DEX dose was 6 μg/kg/h for a 10-min loading, followed by 0.4 μg/kg/h during the procedure. BZDs and analgesics were administered before scope insertion. An additional sedative was administered to achieve a Ramsay sedation scale (RSS) of 4–5. Sedative effect, procedure completion rate, and changes in circulatory and respiratory dynamics were evaluated.

    </sec><sec><title>Results:</title> Mean RSS scores were significantly higher ( p &lt; 0.001) in the DEX (5.1 ± 0.5) compared with the BZD (4.0 ± 0.5) group. The movement score ( p &lt; 0.001) and number of additional sedatives required ( p &lt; 0.01) were lower in the DEX group. The procedure completion rate was significantly higher in the DEX (95.5%) compared with the BZD group (63.6%; p &lt; 0.05). Significant differences in the frequency of hypotension ( p = 1.00), bradycardia ( p = 0.22), and respiratory depression ( p = 0.68) were not noted between groups.

    </sec><sec><title>Conclusions:</title> The addition of DEX to BZD therapy yielded better sedative efficacy, lower excessive movement, a reduction in BZDs used, and a higher procedure complete rate. DEX may be used as an alternative method for BZD-induced inhibition during ERCP.

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    Other Link： http://journals.sagepub.com/doi/full-xml/10.1177/1756284820911822

    DOI： 10.1177/1756284820911822

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  • Management of Multiple Arteriovenous Malformations of the Small Bowel

    Masahiro Hirakawa, Rie Ishizuka, Masanori Sato, Naotaka Hayasaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Tatsuya Ito, Takayuki Nobuoka, Koji Miyanishi, Masayoshi Kobune, Ichiro Takemasa, Junji Kato

    Case Reports in Medicine   2019   1 - 4   2019.12

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    A 62-year-old Japanese female was referred to our hospital with gastrointestinal bleeding. Although small-bowel bleeding was suspected, no bleeding source was identified by enhanced computed tomography (CT), video capsule endoscopy (VCE), and double-balloon enteroscopy (DBE). Five years later, the patient had recurrent intermittent bloody stools with a significant decrease in hemoglobin levels. Although no active bleeding was observed on antegrade DBE, we detected a pulsatile submucosal uplift accompanied by a small red patch on the top of the uplift in the jejunum. Arteriovenous malformation (AVM) was suspected as the cause of small-bowel bleeding. Multiple-phase CT showed a number of small vascular ectasias during the arterial phase in the jejunum, and we confirmed the presence of multiple AVMs in the jejunum by selective angiography. To identify the location of the lesions and determine the minimal surgical margins, we performed intraoperative selective angiography with indocyanine green (ICG) injection. This technique allowed us to clearly observe the region and perform segmental small-bowel resection with minimal surgical margin. The patient reported that she has had no gastrointestinal bleeding at the two years follow-up visit.

    Other Link： http://downloads.hindawi.com/journals/crim/2019/2046857.xml

    DOI： 10.1155/2019/2046857

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  • BH3 profiling discriminates the anti‑apoptotic status of 5‑fluorouracil‑resistant colon cancer cells. Reviewed International journal

    Kazuma Ishikawa, Yutaka Kawano, Yohei Arihara, Tomohiro Kubo, Kohichi Takada, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Oncology reports   42 ( 6 )   2416 - 2425   2019.12

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    5‑Fluorouracil (5‑FU) is a cytotoxic anticancer drug commonly used for patients with advanced colon cancer. This drug effectively reduces the size of tumors to a certain degree; however, cancer cells can gradually acquire resistance, resulting in disease progression. To identify the mechanism of 5‑FU resistance, we established three 5‑FU‑resistant colon cancer cell lines and analyzed both apoptosis‑related protein expression levels and BH3 profiling. These 5‑FU‑resistant colon cancer cell lines acquired apoptotic resistance to 5‑FU. Although apoptosis‑related protein expression levels were altered in each 5‑FU‑resistant colon cancer cell line variably, BH3 profiling indicated BCLXL dependence in 5‑FU‑resistant HT‑29 cells only. Functional BCLXL inhibition in 5‑FU‑resistant HT‑29 cells not only sensitized the cells to apoptosis but also overcame 5‑FU resistance. The apoptotic BIM protein was preferentially sequestered, thereby resulting in acquired dependence on BCLXL for survival. Additionally, in vivo models showed that BCLXL inhibition controlled tumor progression. These results indicate that BH3 profiling facilitates the identification of the functional role of anti‑apoptotic proteins during drug resistance and has clinical implications for colon cancer in targeting specific proteins such as BCLXL.

    DOI： 10.3892/or.2019.7373

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  • Exceptionally rapid response to pembrolizumab in a SMARCA4‐deficient thoracic sarcoma overexpressing PD‐L1: A case report

    Kohichi Takada, Shintaro Sugita, Kazuyuki Murase, Tomoki Kikuchi, Ginji Oomori, Ryo Ito, Naotaka Hayasaka, Koji Miyanishi, Satoshi Iyama, Hiroshi Ikeda, Masayoshi Kobune, Makoto Emori, Junji Kato, Tadashi Hasegawa

    Thoracic Cancer   10 ( 12 )   2312 - 2315   2019.12

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/1759-7714.13215

    DOI： 10.1111/1759-7714.13215

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  • 局所進行食道癌に対するDocetaxel/Nedaplatin/5-FU・放射線同時併用療法(DNF-R)の第II相試験 アップデート解析

    佐藤 昌則, 大沼 啓之, 早坂 尚貴, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 加藤 淳二, 平川 昌宏, 佐川 保, 堀 正和, 染谷 正則, 坂田 耕一

    北海道医学雑誌   94 ( 2 )   121 - 121   2019.11

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  • Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment

    Kohichi Takada, Kazuyuki Murase, Hajime Nakamura, Naotaka Hayasaka, Yohei Arihara, Satoshi Iyama, Hiroshi Ikeda, Makoto Emori, Shintaro Sugita, Katsuyuki Nakamura, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Internal Medicine   58 ( 20 )   3009 - 3012   2019.10

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    Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Internal Medicine  

    DOI： 10.2169/internalmedicine.2790-19

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  • Borderline Resectable膵癌に対する治療戦略

    吉田 真誠, 石川 和真, 久保 智洋, 伊藤 亮, 村瀬 和幸, 高田 弘一, 宮西 浩嗣, 加藤 淳二, 本谷 雅代, 柾木 喜晴, 仲瀬 裕志, 木村 康利, 永山 稔, 今村 将史, 竹政 伊知朗

    日本癌治療学会学術集会抄録集   57回   SY15 - 4   2019.10

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  • Six-transmembrane epithelial antigen of the prostate 1 protects against increased oxidative stress via a nuclear erythroid 2-related factor pathway in colorectal cancer

    Hajime Nakamura, Kohichi Takada, Yohei Arihara, Naotaka Hayasaka, Kazuyuki Murase, Satoshi Iyama, Masayoshi Kobune, Koji Miyanishi, Junji Kato

    Cancer Gene Therapy   26 ( 9-10 )   313 - 322   2019.9

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Other Link： http://www.nature.com/articles/s41417-018-0056-8

    DOI： 10.1038/s41417-018-0056-8

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  • EPO-R+ myelodysplastic cells with ring sideroblasts produce high erythroferrone levels to reduce hepcidin expression in hepatic cells

    Shogo Miura, Masayoshi Kobune, Hiroto Horiguchi, Shohei Kikuchi, Satoshi Iyama, Kazuyuki Murase, Akari Goto, Hiroshi Ikeda, Kohichi Takada, Koji Miyanishi, Junji Kato

    Blood Cells, Molecules, and Diseases   78   1 - 8   2019.9

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bcmd.2019.04.014

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  • 小型混合型肝癌の1例

    大須賀 崇裕, 宮西 浩嗣, 田中 信悟, 中村 元, 坂本 拡基, 大沼 啓之, 村瀬 和幸, 高田 弘一, 小船 雅義, 加藤 淳二, 永山 稔, 木村 康利, 竹政 伊知朗, 辻脇 光洋, 長谷川 匡

    肝臓   60 ( 8 )   294 - 301   2019.8

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  • Combination of eribulin plus AKT inhibitor evokes synergistic cytotoxicity in soft tissue sarcoma cells. Reviewed International journal

    Naotaka Hayasaka, Kohichi Takada, Hajime Nakamura, Yohei Arihara, Yutaka Kawano, Takahiro Osuga, Kazuyuki Murase, Shohei Kikuchi, Satoshi Iyama, Makoto Emori, Shintaro Sugita, Tadashi Hasegawa, Akira Takasawa, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Scientific reports   9 ( 1 )   5759 - 5759   2019.4

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    An activated AKT pathway underlies the pathogenesis of soft tissue sarcoma (STS), with over-expressed phosphorylated AKT (p-AKT) correlating with a poor prognosis in a subset of STS cases. Recently, eribulin, a microtubule dynamics inhibitor, has demonstrated efficacy and is approved in patients with advanced/metastatic liposarcoma and breast cancer. However, mechanisms of eribulin resistance and/or insensitivity remain largely unknown. In this study, we demonstrated that an increased p-AKT level was associated with eribulin resistance in STS cells. We found a combination of eribulin with the AKT inhibitor, MK-2206, synergistically inhibited STS cell growth in vivo as well as in vitro. Mechanistically, eribulin plus MK-2206 induced G1 or G2/M arrest by down-regulating cyclin-dependent kinases, cyclins and cdc2, followed by caspase-dependent apoptosis in STS cells. Our findings demonstrate the significance of p-AKT signaling for eribulin-resistance in STS cells and provide a rationale for the development of an AKT inhibitor in combination with eribulin to treat patients with STS.

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  • リツキシマブが原因と考えられたTEN型薬疹の1例

    松井 馨之, 澄川 靖之, 箕輪 智幸, 熊谷 綾子, 神谷 崇文, 宇原 久, 村瀬 和幸

    日本皮膚科学会雑誌   129 ( 1 )   45 - 45   2019.1

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  • miR-7977 inhibits the Hippo-YAP signaling pathway in bone marrow mesenchymal stromal cells. Reviewed International journal

    Masahiro Yoshida, Hiroto Horiguchi, Shohei Kikuchi, Satoshi Iyama, Hiroshi Ikeda, Akari Goto, Yutaka Kawano, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Junji Kato, Masayoshi Kobune

    PloS one   14 ( 3 )   e0213220   2019

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    We and others have demonstrated that various abnormalities of the bone marrow (BM) mesenchymal stromal cells (MSCs) such as aberrant cytokine expression, abnormal hedgehog signaling, and impaired miRNA biogenesis are observed in patients with acute myeloid leukemia (AML). However, underlying mechanisms to induce the dysfunction of BM MSCs have not yet been clarified. We previously showed that AML cells release abundant exosomal miR-7977, which, in turn, enters BM mesenchymal stromal cells (MSCs). However, the precise function of miR-7977 is not known. In this study, we performed transduction of a miR-7977 mimic into MSCs, compared transcriptomes between control-transduced (n = 3) and miR-7977-transduced MSCs (n = 3), and conducted pathway analysis. The array data revealed that the expression of 0.05% of genes was reduced 2-fold and the expression of 0.01% of genes was increased 2-fold. Interestingly, approximately half of these genes possessed a miR-7977 target site, while the other genes did not, suggesting that miR-7977 regulates the gene expression level directly and indirectly. Gene set enrichment analysis showed that the gene sets of Yes-associated protein 1 (YAP1) _up were significantly enriched (p<0.001, q<0.25), suggesting that miR-7977 modulates the Hippo-YAP signaling pathway. Visualization of pathway and network showed that miR-7977 significantly reduced the expression of Hippo core kinase, STK4. miR-7977 inactivated the Hippo-YAP signaling pathway as proven by GFP-tagged YAP nuclear trans localization and TEAD reporter assay. The miR-7977-transduced MSC cell line, HTS-5, showed elevated saturation density and enhanced entry into the cell cycle. These results suggest that miR-7977 is a critical factor that regulates the Hippo-YAP signaling pathway in BM-MSCs and may be involved in the upregulation of leukemia-supporting stroma growth.

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  • A case of small combined hepatocellular-cholangiocellular carcinoma

    Takahiro Osuga, Koji Miyanishi, Shingo Tanaka, Hajime Nakamura, Hiroki Sakamoto, Hiroyuki Onuma, Kazuyuki Murase, Koichi Takada, Masayoshi Kobune, Junji Kato, Minoru Nagayama, Yasutoshi Kimura, Ichiro Takemasa, Mitsuhiro Tsujiwaki, Tadashi Hasegawa

    Acta Hepatologica Japonica   60 ( 8 )   294 - 301   2019

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    DOI： 10.2957/kanzo.60.294

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  • Early Lymph Node Metastasis May Predict Poor Prognosis in Soft Tissue Sarcoma. International journal

    Makoto Emori, Hiroyuki Tsuchie, Hiroyuki Nagasawa, Tomoko Sonoda, Arihiko Tsukamoto, Junya Shimizu, Yasutaka Murahashi, Emi Mizushima, Kohichi Takada, Kazuyuki Murase, Kotoe Iesato, Keita Igarashi, Tsukasa Hori, Masaki Yamamoto, Shintaro Sugita, Naohisa Miyakoshi, Tadashi Hasegawa, Yoichi Shimada, Toshihiko Yamashita

    International journal of surgical oncology   2019   6708474 - 6708474   2019

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    Background: Lymph node metastasis (LNM) is a relatively rare event in soft tissue sarcoma. An association between the timing of LNM detection and patient prognosis is presently unknown. Patients and Methods: We retrospectively analyzed the clinicopathological features of 33 patients with LNM between 2001 and 2015. Analysis of the timing of LNM diagnosis was grouped according to patients presenting LNM in either <8 months (the median time from primary tumor diagnosis to LNM) or ≥8 months after primary tumor diagnosis. Results: A relationship between the primary tumor size and the timing of the LNM was not significantly found (Rs = 0.0088, p=0.96). Sixteen patients had an LNM detection duration of <8 months, and 17 patients had a duration of ≥8 months. The 5-year survival for patients with an LNM detection duration of <8 months and ≥8 months was 19% and 71%, respectively (p=0.0016). There were 19 patients with pulmonary metastases. Among them, there were 13 patients with a duration of primary tumor diagnosis to LNM of <8 months and 6 with a duration of ≥8 months (p=0.01). Conclusion: Early LNM (<8 months) may predict poor prognosis in soft tissue sarcoma.

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  • Trastuzumab-Based Combination Chemotherapy in Patients with Human Epidermal Growth Factor Receptor-2-Positive Metastatic Carcinoma ex Pleomorphic Adenoma

    Yohei Arihara, Kazuyuki Murase, Kohichi Takada, Naotaka Hayasaka, Shogo Miura, Koji Miyanishi, Masayoshi Kobune, Makoto Kurose, Yukinori Akiyama, Shintaro Sugita, Junji Kato

    Case Reports in Oncology   11 ( 3 )   835 - 841   2018.12

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    Background: Carcinoma ex pleomorphic adenoma (CXPA) is a rare histologic subtype of lacrimal gland and submandibular gland cancer. Currently, there is no standard treatment for metastatic CXPA, although some case reports have explored the role of targeted agents in chemotherapy. A few histopathologic analyses have shown that some of these tumors overexpress human epidermal growth factor receptor-2 (HER2), suggesting a potential role for HER2-based therapy. We report here two cases of metastatic CXPA that were treated with trastuzumab-based chemotherapy (IRB approved) with rapid and significant responses. Case Report 1: A 66-year-old male was diagnosed as HER2-positive CXPA of the right lacrimal gland with multiple bone and lymph node metastases. Combination chemotherapy with trastuzumab (Tmab) and nanoparticle albumin-bound paclitaxel (nabPTX) was initiated. A rapid response was confirmed, and after seven cycles of treatment, CR(complete response) was achieved. Case Report 2: A 67-year-old female was diagnosed with HER2 positive CXPA of the right submandibular gland. Multiple pulmonary metastatic lesions were detected after surgery, and combination chemotherapy with Tmab and nab-PTX was initiated. A rapid partial response (PR) was confirmed, and she eventually became disease-free. Conclusion: In the absence of definitive clinical trials, which are unlikely to be performed due to the rarity of HER2-positive CXPA, therapeutic information must be obtained from case reports. Some reports, such as this one, have suggested a potential utility of trastuzumab-based chemotherapy.

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  • Denosumab prevents bone loss in newly diagnosed malignant lymphoma patients undergoing corticosteroid-containing chemotherapy: A prospective, non-randomized study

    Ayumi Tatekoshi, Tsutomu Sato, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Masahiro Yoshida, Soushi Ibata, Akari Hashimoto, Yusuke Kamihara, Hiroto Horiguchi, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    Sapporo Medical journal   87 ( 1-6 )   35 - 47   2018.12

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  • 低用量IL2はBCL2の発現を誘導することでCD4制御性T細胞のアポトーシスを抑制する(Low-close interleukin-2 induces BCL2 expression and resistance to apoptosis in CD4 regulatory T Cells) Reviewed

    松野 鉄平, 村瀬 和幸, 高田 弘一, 河野 豊, 平川 昌宏, 宮西 浩嗣, 小船 雅義, 加藤 淳二

    札幌医学雑誌   87 ( 1-6 )   49 - 61   2018.12

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  • Secondary malignant giant cell tumor of bone with histone H3.3 mutation: A case series

    Makoto Emori, Satoshi Nagoya, Masato Sugawara, Emi Mizushima, Junya Shimizu, Yasutaka Murahashi, Kazuyuki Murase, Kohichi Takada, Shintaro Sugita, Michiaki Takagi, Tadashi Hasegawa, Toshihiko Yamashita

    Journal of Orthopaedic Science   2018.12

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    DOI： 10.1016/j.jos.2018.11.002

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  • High expression of nucleoporin 133 mRNA in bone marrow CD138+ cells is a poor prognostic factor in multiple myeloma Reviewed

    Soushi Ibata, Masayoshi Kobune, Shohei Kikuchi, Masahiro Yoshida, Shogo Miura, Hiroto Horiguchi, Kazuyuki Murase, Satoshi Iyama, Kohichi Takada, Koji Miyanishi, Junji Kato

    Oncotarget   9 ( 38 )   25127 - 25135   2018.5

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    DOI： 10.18632/oncotarget.25350

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  • Clostridium difficile肝膿瘍の1例 Reviewed

    松野 鉄平, 田中 信悟, 宮西 浩嗣, 河野 豊, 中村 元, 坂本 拡基, 早坂 尚貴, 石川 和真, 村瀬 和幸, 高田 弘一, 高梨 訓博, 勝木 伸一, 小船 雅義, 加藤 淳二

    肝臓   59 ( 3 )   180 - 186   2018.3

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  • A case of cisplatin-refractory advanced pure seminoma showing complete remission after treatment with high-dose carboplatin plus etoposide as fourth-line salvage chemotherapy

    Kimihito Tachikawa, Naotaka Nishiyama, Takashi Muranaka, Koichi Takada, Kazuyuki Murase, Tsutomu Kouno, Kato Junji, Naoya Masumori

    International Cancer Conference Journal   7 ( 1 )   6 - 10   2018.1

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    Other Link： http://link.springer.com/content/pdf/10.1007/s13691-017-0308-8.pdf

    DOI： 10.1007/s13691-017-0308-8

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  • ART療法中に多発血栓症を併発した悪性リンパ腫患者の一例

    池田 博, 吉田 正宏, 舘越 鮎美, 菊地 尚平, 村瀬 和幸, 高田 弘一, 井山 諭, 小船 雅義, 村上 則子, 宮越 郁子, 又村 了輔, 國本 雄介, 加藤 淳二

    日本エイズ学会誌   19 ( 4 )   501 - 501   2017.11

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  • Small molecule CP-31398 induces reactive oxygen species-dependent apoptosis in human multiple myeloma Reviewed

    Yohei Arihara, Kohichi Takada, Yusuke Kamihara, Naotaka Hayasaka, Hajime Nakamura, Kazuyuki Murase, Hiroshi Ikeda, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    ONCOTARGET   8 ( 39 )   65889 - 65899   2017.9

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    DOI： 10.18632/oncotarget.19508

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  • [A Case of Chronic Myelogenous Leukemia That Developed Fibrous Pericarditis Owing to Nilotinib Use]. Reviewed

    Shogo Miura, Kazuyuki Murase, Akira Sakurada, Kohichi Takada, Satoshi Iyama, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Atsuko Muranaka, Kazutoshi Tachibana, Junji Kato

    Gan to kagaku ryoho. Cancer & chemotherapy   44 ( 6 )   529 - 531   2017.6

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    A 64-year-old man was diagnosed with chronic-phase chronic myelogenous leukemia(CML)in May 2009. He was treated with imatinib and achieved complete cytogenetic response(CCyR)in 2 months. After 4 months of treatment, he developed interstitial pneumonia and became intolerant to imatinib. He was then switched to nilotinib from October of the same year. In June 2013, he was diagnosed with drug-induced pericarditis resulting from nilotinib use, and thus, nilotinib was discontinued. Subsequently, he was followed up without specific treatment for CML. In January 2014, he was admitted to the Dept. of Cardiovascular, Renal and Metabolic Medicine at our hospital because of heart failure. After examinations of cardiac function, he was diagnosed with constrictive pericarditis. Therefore, pericardiolysis was performed by the Dept. of Cardiovascular Surgery at our hospital. Pathologic findings showed hyaline-like fibrous tissue proliferation in the pericardium, which was diagnosed as fibrous pericarditis induced by nilotinib. We report a case of chronic myelogenous leukemia that developed fibrous pericarditis owing to nilotinib use.

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  • 低分子化合物CP-31398は多発性骨髄腫に対して活性酸素種依存的なアポトーシスを誘導する Reviewed

    在原 洋平, 高田 弘一, 神原 悠輔, 河野 豊, 早坂 尚貴, 中村 元, 菊地 尚平, 村瀬 和幸, 井山 諭, 池田 博, 佐藤 勉, 宮西 浩嗣, 小船 雅義, 加藤 淳二

    International Journal of Myeloma   7 ( 1 )   76 - 76   2017.4

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  • 肝細胞癌の治療前ステージングにおけるEOB-MRIおよびDiffusion-Weighted Imagingの有用性についての検討 Reviewed

    坂本 拡基, 宮西 浩嗣, 田中 信吾, 河野 豊, 中村 元, 櫻田 晃, 石川 和真, 佐藤 昌則, 菊地 尚平, 村瀬 和幸, 高田 弘一, 加藤 淳二

    肝臓   58 ( Suppl.1 )   A296 - A296   2017.4

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  • A typical presentation of primary pulmonary epithelioid sarcoma misdiagnosed as non-small cell lung cancer

    Makoto Emori, Mitsuharu Tamakawa, Mitsunori Kaya, Kohichi Takada, Kazuyuki Murase, Chisa Fujita, Sayuri Sato, Ryuji Takahashi, Kanako C. Hatanaka, Shintaro Sugita, Hiroshi Hirano, Toshihiko Yamashita, Tadashi Hasegawa

    Pathology International   67 ( 4 )   222 - 224   2017.4

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    DOI： 10.1111/pin.12503

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  • 非アルコール性脂肪性肝疾患の組織学的診断時における肝発癌予測因子についての検討 Reviewed

    田中 信悟, 宮西 浩嗣, 坂本 拡基, 佐藤 昌則, 櫻田 晃, 池田 裕貴, 石川 和真, 河野 豊, 村瀬 和幸, 高田 弘一, 加藤 淳二

    日本消化器病学会雑誌   114 ( 臨増総会 )   A311 - A311   2017.3

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  • Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells Reviewed

    Yutaka Okagawa, Kohichi Takada, Yohei Arihara, Shohei Kikuchi, Takahiro Osuga, Hajime Nakamura, Yusuke Kamihara, Naotaka Hayasaka, Makoto Usami, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    PLOS ONE   11 ( 12 )   2016.12

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    DOI： 10.1371/journal.pone.0168355

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  • A phase II trial of small-dose bortezomib, lenalidomide and dexamethasone (sVRD) as consolidation/maintenance therapy in patients with multiple myeloma Reviewed

    Soushi Ibata, Tsutomu Sato, Hiroyuki Kuroda, Yasuhiro Nagamachi, Satoshi Iyama, Akihito Fujimi, Yusuke Kamihara, Yuichi Konuma, Masahiro Yoshida, Ayumi Tatekoshi, Akari Hashimoto, Hiroto Horiguchi, Kaoru Ono, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Masayoshi Kobune, Yasuo Hirayama, Junji Kato

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   78 ( 5 )   1041 - 1049   2016.11

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    DOI： 10.1007/s00280-016-3163-y

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  • The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma. Reviewed International journal

    Yusuke Kamihara, Kohichi Takada, Tsutomu Sato, Yutaka Kawano, Kazuyuki Murase, Yohei Arihara, Shohei Kikuchi, Naotaka Hayasaka, Makoto Usami, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune, Junji Kato

    Oncotarget   7 ( 39 )   64330 - 64341   2016.9

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    Deregulated iron metabolism underlies the pathogenesis of many human cancers. Recently, low expression of ferroportin, which is the only identified non-heme iron exporter, has been associated with significantly reduced overall survival in multiple myeloma (MM); however, the altered iron metabolism in MM biology remains unclear. In this study we demonstrated, by live cell imaging, that MM cells have increased intracellular iron levels as compared with normal cells. In experiments to test the effect of iron chelation on the growth of MM cells, we found that deferasirox (DFX), an oral iron chelator used to treat iron overload in clinical practice, inhibits MM cell growth both in vivo and in vitro. Mechanistically, DFX was found to induce apoptosis of MM cells via the inhibition of proline-rich tyrosine kinase 2 (Pyk2), which is known to promote tumor growth in MM. Inhibition of Pyk2 is caused by the suppression of reactive oxygen species, and leads to downregulation of the Wnt/β-catenin signaling pathway. Taken together, our findings indicate that high levels of intracellular iron, which might be due to low ferroportin expression, play a role in MM pathophysiology. Therefore, DFX may provide a therapeutic option for MM that is driven by deregulated iron homeostasis and/or Pyk2/Wnt signaling.

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  • [Treatment Outcomes of Adult-Onset Ewing Sarcoma: A Single-Center Retrospective Study of Five Cases]. Reviewed

    Kazuyuki Murase, Kohichi Takada, Yusuke Kamihara, Makoto Usami, Masahiro Yoshida, Ayumi Tatekoshi, Akari Hashimoto, Yohei Arihara, Naotaka Hayasaka, Shogo Miura, Satoshi Iyama, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Makoto Emori, Mitsunori Kaya, Toshihiko Yamashita, Shintaro Sugita, Tadashi Hasegawa, Junji Kato

    Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 8 )   1015 - 8   2016.8

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    UNLABELLED: We report the treatment outcomes of 5 cases of adult-onset Ewing sarcoma(ES)managed between 2011 and 2014. We examined prognostic factors including the primary lesion, tumor size, metastatic status, and serum LDH levels. RESULTS: The locations of the primary lesions included the limbs in 1 case and the trunk in 4; the cases in the trunk had a worse prognosis than that in the limbs. Tumor size was greater than 8 cm in only 1 patient, who also displayed evidence of metastases at presentation and high LDH levels. All the patients received chemotherapy consisting of alternating vincristine, doxorubicin, and cyclophosphamide(VDC)and etoposide and ifosfamide(IE). Surgery was selected for the treatment of 4 patients, and radiotherapy was administered to 1 patient for local treatment of the tumor. A median follow-up duration of 31.6 months revealed the 2-year overall survival rate and progression-free survival rate to be 80.0%. CONCLUSIONS: The prognosis of patients with adult-onset ES is poor; however, combined modality therapy, including VDC-IE, was demonstrated to improve the outcome of patients in the present study. Nevertheless, the patient with tumor size exceeding 8 cm, metastasis, and high LDH levels, relapsed 1 year after treatment, as reported previously. Further investigation is required to clarify the factors affecting prognosis in adults, and to develop effective therapies for patients with a poor prognosis.

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  • 肛門周囲の感覚障害で発症し、前立腺生検にて診断に至った血管内リンパ腫(IVL)の1例

    齋藤 太郎, 中村 祐貴, 鈴木 秀一郎, 津田 笑子, 林 貴士, 齊藤 正樹, 久原 真, 川又 純, 下濱 俊, 村瀬 和幸, 高田 弘一

    臨床神経学   56 ( 6 )   451 - 451   2016.6

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  • Isoform D of vascular endothelial growth factor in systemic capillary leak syndrome: a case report. Reviewed International journal

    Soushi Ibata, Tsutomu Sato, Kohichi Takada, Ayumi Tatekoshi, Akari Hashimoto, Yusuke Kamihara, Wataru Jomen, Hiroto Horiguchi, Kaoru Ono, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    Journal of medical case reports   10   125 - 125   2016.5

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    BACKGROUND: Systemic capillary leak syndrome is a rare condition characterized by episodic attacks of hypovolemia due to systemic capillary hyperpermeability, which results in profound hypotension and edema. Although the implication of vascular endothelial growth factor, angiopoietin-2, and C-X-C motif chemokine 10 has been suggested, the pathogenesis of systemic capillary leak syndrome remains unclear. In this report, we describe a case of systemic capillary leak syndrome in which serum isoform D of vascular endothelial growth factor was elevated. To the best of our knowledge, this is the first reported case of systemic capillary leak syndrome in which isoform D of vascular endothelial growth factor is suggested as the plausible biomarker. CASE PRESENTATION: A 41-year-old Japanese man was transferred to our emergency department. He was hypotensive, tachycardic, and edematous over the trunk and all four limbs. He received aggressive intravenous fluid therapy and underwent fasciotomy of the right forearm to prevent muscle necrosis. A diagnosis of systemic capillary leak syndrome was suspected. The presence of serum monoclonal immunoglobulin G and κ light chain supported this diagnosis. Prevention of hypotensive crises was unsuccessfully attempted with theophylline, intravenous immunoglobulin, high-dose dexamethasone, bortezomib, melphalan, and prednisolone; however, the patient's attacks dramatically disappeared after the introduction of thalidomide. The serum of the patient was stored soon after the onset of hypotensive crisis and analyzed to profile possible mediators responsible for the capillary leak. The concentration of vascular endothelial growth factor, angiopoietin-2, and C-X-C motif chemokine 10 were all within normal ranges. Meanwhile, we found that isoform D of vascular endothelial growth factor was elevated, which was normalized after the introduction of thalidomide. CONCLUSIONS: In our patient, isoform D of vascular endothelial growth factor (instead of vascular endothelial growth factor) may have been a causative factor of hypotensive crises, since isoform D contributes to vascular endothelial growth factor receptor-2 signaling, which is the major mediator of the permeability-enhancing effects of vascular endothelial growth factor. We suggest the measurement of isoform D of vascular endothelial growth factor in patients with systemic capillary leak syndrome in whose serum vascular endothelial growth factor is not elevated.

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  • Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms Reviewed

    Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Masahiro Yoshida, Masaki Murata, Kazuyuki Murase, Satoshi Iyama, Kohichi Takada, Tsutomu Sato, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yutaka Kawano, Koji Miyanishi, Norimasa Sawada, Junji Kato

    HAEMATOLOGICA   101 ( 4 )   437 - 447   2016.4

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    DOI： 10.3324/haematol.2015.134932

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  • Narrow-Band Ultraviolet B Phototherapy Ameliorates Acute Graft-Versus-Host Disease of the Intestine by Expansion of Regulatory T Cells. Reviewed

    Hashimoto A, Sato T, Iyama S, Yoshida M, Ibata S, Tatekoshi A, Kamihara Y, Horiguchi H, Murase K, Kawano Y, Takada K, Miyanishi K, Kobune M, Ichimiya S, Kato J

    PloS one   11 ( 3 )   e0152823   2016.3

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  • RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells Reviewed

    Fumito Tamura, Yasushi Sato, Masahiro Hirakawa, Makoto Yoshida, Michihiro Ono, Takahiro Osuga, Yutaka Okagawa, Naoki Uemura, Yohei Arihara, Kazuyuki Murase, Yutaka Kawano, Satoshi Iyama, Kohichi Takada, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    GASTRIC CANCER   19 ( 1 )   85 - 97   2016.1

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    DOI： 10.1007/s10120-014-0454-z

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  • [Neurolymphomatosis of the sciatic nerve diagnosed by FDG-PET/CT]. Reviewed

    Usami M, Murase K, Takada K, Iijima K, Yoshida M, Tatekoshi A, Hashimoto A, Iyama S, Sato T, Kobune M, Takimoto R, Kaya M, Yamashita T, Morita R, Hasegawa T, Kato J

    [Rinsho ketsueki] The Japanese journal of clinical hematology   57 ( 1 )   52 - 55   2016.1

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  • BAK is a predictive and prognostic biomarker for the therapeutic effect of docetaxel treatment in patients with advanced gastric cancer. Reviewed

    Kubo T, Kawano Y, Himuro N, Sugita S, Sato Y, Ishikawa K, Takada K, Murase K, Miyanishi K, Sato T, Takimoto R, Kobune M, Nobuoka T, Hirata K, Takayama T, Mori M, Hasegawa T, Kato J

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   19 ( 3 )   827 - 838   2015.10

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  • Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial Reviewed

    Yasuo Hirayama, Kunihiko Ishitani, Yasushi Sato, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Hiroyuki Kuroda, Yasuhiro Nagamachi, Yuichi Konuma, Akihito Fujimi, Tamotsu Sagawa, Kaoru Ono, Hiroto Horiguchi, Takeshi Terui, Kazuhiko Koike, Toshiro Kusakabe, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   20 ( 5 )   866 - 871   2015.10

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  • A dose-escalation study of oxaliplatin/capecitabine/irinotecan (XELOXIRI) and bevacizumab as a first-line therapy for patients with metastatic colorectal cancer Reviewed

    Yasushi Sato, Hiroyuki Ohnuma, Masahiro Hirakawa, Minoru Takahashi, Takahiro Osuga, Yutaka Okagawa, Kazuyuki Murase, Kohichi Takada, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Kenji Okita, Toru Mizuguchi, Tomohisa Furuhata, Koichi Hirata, Junji Kato

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   75 ( 3 )   587 - 594   2015.3

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    DOI： 10.1007/s00280-014-2672-9

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  • Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation Reviewed

    Kazuyuki Murase, Haesook T. Kim, O. R. Gregory Bascug, Yutaka Kawano, Jeremy Ryan, Ken-ichi Matsuoka, Matthew S. Davids, John Koreth, Vincent T. Ho, Corey Cutler, Philippe Armand, Edwin P. Alyea, Bruce R. Blazar, Joseph H. Antin, Robert J. Soiffer, Anthony Letai, Jerome Ritz

    HAEMATOLOGICA   99 ( 9 )   1499 - 1508   2014.9

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    DOI： 10.3324/haematol.2014.104166

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  • Efficacy of Enteral Supplementation Enriched with Glutamine, Fiber, and Oligosaccharide on Mucosal Injury following Hematopoietic Stem Cell Transplantation. Reviewed

    Iyama S, Sato T, Tatsumi H, Hashimoto A, Tatekoshi A, Kamihara Y, Horiguchi H, Ibata S, Ono K, Murase K, Takada K, Sato Y, Hayashi T, Miyanishi K, Akizuki E, Nobuoka T, Mizugichi T, Takimoto R, Kobune M, Hirata K, Kato J

    Case reports in oncology   7 ( 3 )   692 - 699   2014.9

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  • Effective Treatment of Metastatic Rhabdomyosarcoma with Pazopanib Reviewed

    Akari Hashimoto, Kohichi Takada, Rishu Takimoto, Hiroto Horiguchi, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Kaoru Ono, Ayumi Tatekoshi, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune, Yasuo Hirayama, Hiroshi Kitamura, Katsuya Nakanishi, Naoya Masumori, Tadashi Hasegawa, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   41 ( 8 )   1041 - 1044   2014.8

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  • Activated Hepatic Stellate Cells Are Dependent on Self-collagen, Cleaved by Membrane Type 1 Matrix Metalloproteinase for Their Growth Reviewed

    Naoko Kubo Birukawa, Kazuyuki Murase, Yasushi Sato, Akemi Kosaka, Akihiro Yoneda, Hiroki Nishita, Ryosuke Fujita, Miyuki Nishimura, Takafumi Ninomiya, Keiko Kajiwara, Miyono Miyazaki, Yusuke Nakashima, Sigenori Ota, Yuya Murakami, Yasunobu Tanaka, Kenjiro Minomi, Yasuaki Tamura, Yoshiro Niitsu

    JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 29 )   20209 - 20221   2014.7

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    DOI： 10.1074/jbc.M113.544494

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  • Narrowband ultraviolet B phototherapy ameliorates acute graft-versus-host disease by a mechanism involving in vivo expansion of CD4+CD25+Foxp3+regulatory T cells Reviewed

    Satoshi Iyama, Kazuyuki Murase, Tsutomu Sato, Akari Hashimoto, Ayumi Tatekoshi, Hiroto Horiguchi, Yusuke Kamihara, Kaoru Ono, Shohei Kikuchi, Kohichi Takada, Yutaka Kawano, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Satoru Mori, Junji Kato, Toshiharu Yamashita, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   99 ( 4 )   471 - 476   2014.4

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    DOI： 10.1007/s12185-014-1530-1

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  • Combination chemotherapy of azacitidine and cetuximab for therapy-related acute myeloid leukemia following oxaliplatin for metastatic colorectal cancer Reviewed

    Akari Hashimoto, Kohichi Takada, Hiroto Horiguchi, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Yusuke Kamihara, Kaoru Ono, Ayumi Tatekoshi, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Tomohisa Furuhata, Masayoshi Kobune, Rishu Takimoto, Koichi Hirata, Junji Kato

    Case Reports in Oncology   7 ( 2 )   316 - 322   2014.3

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    DOI： 10.1159/000363100

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  • Fucosylated TGF-beta receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells Reviewed

    M. Hirakawa, R. Takimoto, F. Tamura, M. Yoshida, M. Ono, K. Murase, Y. Sato, T. Osuga, T. Sato, S. Iyama, K. Miyanishi, K. Takada, T. Hayashi, M. Kobune, J. Kato

    BRITISH JOURNAL OF CANCER   110 ( 1 )   156 - 163   2014.1

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    DOI： 10.1038/bjc.2013.699

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  • [Follicular lymphoma complicated with myelofibrosis and macroglobulinemia at initial presentation]. Reviewed

    Kuroda H, Abe T, Jomen W, Yoshida M, Matsuno T, Sato M, Yamada M, Sakurai T, Fujii S, Maeda M, Fujita M, Nagashima K, Murase K, Kato J

    [Rinsho ketsueki] The Japanese journal of clinical hematology   54   2068 - 2073   2013.11

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  • Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes Reviewed

    Hirotoshi Ishiwatari, Yasushi Sato, Kazuyuki Murase, Akihiro Yoneda, Ryosuke Fujita, Hiroki Nishita, Naoko Kubo Birukawa, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Shigenori Ota, Yasutoshi Kimura, Koichi Hirata, Junji Kato, Yoshiro Niitsu

    GUT   62 ( 9 )   1328 - 1339   2013.9

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    DOI： 10.1136/gutjnl-2011-301746

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  • Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Reviewed International journal

    Ken-ichi Matsuoka, John Koreth, Haesook T Kim, Gregory Bascug, Sean McDonough, Yutaka Kawano, Kazuyuki Murase, Corey Cutler, Vincent T Ho, Edwin P Alyea, Philippe Armand, Bruce R Blazar, Joseph H Antin, Robert J Soiffer, Jerome Ritz

    Science translational medicine   5 ( 179 )   179ra43   2013.4

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    CD4(+)Foxp3(+) regulatory T cells (Tregs) play a central role in the maintenance of immune tolerance after allogeneic hematopoietic stem cell transplantation. We recently reported that daily administration of low-dose interleukin-2 (IL-2) induces selective expansion of functional Tregs and clinical improvement of chronic graft-versus-host disease (GVHD). To define the mechanisms of action of IL-2 therapy, we examined the immunologic effects of this treatment on homeostasis of CD4(+) T cell subsets after transplant. We first demonstrated that chronic GVHD is characterized by constitutive phosphorylation of signal transducer and activator of transcription 5 (Stat5) in conventional CD4(+) T cells (Tcons) associated with elevated amounts of IL-7 and IL-15 and relative functional deficiency of IL-2. IL-2 therapy resulted in the selective increase of Stat5 phosphorylation in Tregs and a decrease of phosphorylated Stat5 in Tcons. Over an 8-week period, IL-2 therapy induced a series of changes in Treg homeostasis, including increased proliferation, increased thymic export, and enhanced resistance to apoptosis. Low-dose IL-2 had minimal effects on Tcons. These findings define the mechanisms whereby low-dose IL-2 therapy restores the homeostasis of CD4(+) T cell subsets and promotes the reestablishment of immune tolerance.

    DOI： 10.1126/scitranslmed.3005265

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  • Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms Reviewed

    M. Kobune, S. Iyama, S. Kikuchi, H. Horiguchi, T. Sato, K. Murase, Y. Kawano, K. Takada, K. Ono, Y. Kamihara, T. Hayashi, K. Miyanishi, Y. Sato, R. Takimoto, J. Kato

    BLOOD CANCER JOURNAL   2   2012.9

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    DOI： 10.1038/bcj.2012.36

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  • Intermittent administration of recombinant human soluble thrombomodulin successfully controlled chronic disseminated intravascular coagulation in a patient with dissecting aortic aneurysm on an outpatient basis Reviewed

    Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Yusuke Kamihara, Kaoru Ono, Shohei Kikuchi, Kohichi Takada, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    BLOOD COAGULATION & FIBRINOLYSIS   23 ( 6 )   548 - 550   2012.9

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    DOI： 10.1097/MBC.0b013e32835510d6

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  • Improvement of iron-mediated oxidative DNA damage in patients with transfusion-dependent myelodysplastic syndrome by treatment with deferasirox Reviewed

    Shohei Kikuchi, Masayoshi Kobune, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Yutaka Kawano, Kohichi Takada, Kaoru Ono, Yumiko Kaneko, Koji Miyanishi, Yasushi Sato, Tsuyoshi Hayashi, Rishu Takimoto, Junji Kato

    FREE RADICAL BIOLOGY AND MEDICINE   53 ( 4 )   643 - 648   2012.8

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    DOI： 10.1016/j.freeradbiomed.2012.06.006

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  • Targeting Anticancer Drug Delivery to Pancreatic Cancer Cells Using a Fucose-Bound Nanoparticle Approach Reviewed

    Makoto Yoshida, Rishu Takimoto, Kazuyuki Murase, Yasushi Sato, Masahiro Hirakawa, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Takahiro Osuga, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Masayoshi Kobune, Junji Kato

    PLOS ONE   7 ( 7 )   e39545   2012.7

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    DOI： 10.1371/journal.pone.0039545

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  • Prognostic significance of serum ferritin level at diagnosis in myelodysplastic syndrome Reviewed

    Shohei Kikuchi, Masayoshi Kobune, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Yutaka Kawano, Kohichi Takada, Kaoru Ono, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   95 ( 5 )   527 - 534   2012.5

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  • Successful Treatment by Fibrin Glue Sealant for Pneumothorax with Chronic GVHD Resistant to Autologous Blood Patch Pleurodesis Reviewed

    Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Shohei Kikuchi, Yusuke Kamihara, Kaoru Ono, Kohichi Takada, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Takuro Obama, Masahiro Miyajima, Atsushi Watanabe, Tetsuya Higami, Yasuo Hirayama, Junji Kato

    INTERNAL MEDICINE   51 ( 15 )   2011 - 2014   2012

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    DOI： 10.2169/internalmedicine.51.7355

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  • A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine Reviewed

    Sho Takahashi, Yasushi Sato, Tamotsu Sagawa, Shingo Tanaka, Kazuyuki Murase, Kohichi Takada, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Ganji Kuroiwa, Michiaki Hirayama, Tetsuro Okamoto, Junji Kato

    Journal of Japanese Society of Gastroenterology   108 ( 8 )   1405 - 1412   2011.8

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    DOI： 10.11405/nisshoshi.108.1405

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  • Novel missense mutation in the TMPRSS6 gene in a Japanese female with iron-refractory iron deficiency anemia Reviewed

    Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Yusuke Kamihara, Kaoru Ono, Shohei Kikuchi, Kohichi Takada, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   94 ( 1 )   101 - 103   2011.7

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    DOI： 10.1007/s12185-011-0881-0

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  • Iron chelator deferasirox rescued mice from Fas-induced fulminant hepatitis Reviewed

    Tsutomu Sato, Masayoshi Kobune, Kazuyuki Murase, Yukari Kado, Tetsuro Okamoto, Shingo Tanaka, Shohei Kikuchi, Hiroyuki Nagashima, Yutaka Kawano, Kohichi Takada, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

    HEPATOLOGY RESEARCH   41 ( 7 )   660 - 667   2011.7

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    DOI： 10.1111/j.1872-034X.2011.00821.x

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  • Establishment of a simple test for iron absorption from the gastrointestinal tract Reviewed

    Masayoshi Kobune, Koji Miyanishi, Kohichi Takada, Yutaka Kawano, Hiroyuki Nagashima, Shohei Kikuchi, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Junji Kato

    INTERNATIONAL JOURNAL OF HEMATOLOGY   93 ( 6 )   715 - 719   2011.6

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    DOI： 10.1007/s12185-011-0878-8

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  • Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer Reviewed

    Masahiro Hirakawa, Yasushi Sato, Hiroyuki Ohnuma, Tamotsu Sagawa, Hirotoshi Ishiwatari, Kazuyuki Murase, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    Journal of Japanese Society of Gastroenterology   108 ( 2 )   231 - 237   2011.2

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    DOI： 10.11405/nisshoshi.108.231

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  • ENDOSCOPIC FINDINGS OF ENTEROPATHY-TYPE T-CELL LYMPHOMA BY DOUBLE-BALLOON ENTEROSCOPY AND CAPSULE ENDOSCOPY Reviewed

    Yasushi Sato, Michihiro Ono, Tamotsu Sagawa, Rishu Takimoto, Masahiro Hirakawa, Hiroyuki Ohnuma, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    DIGESTIVE ENDOSCOPY   22 ( 3 )   243 - 245   2010.7

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  • Therapeutic results in patients with biphenotypic acute leukemia at Sapporo Medical University Hospital Reviewed

    Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato

    Japanese Journal of Cancer and Chemotherapy   37 ( 10 )   2011 - 2013   2010

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  • Treatment of Cirrhosis with Vitamin A-Coupled Liposomes Carrying siRNA against Heat Shock Protein Reviewed

    Yoshiro Niitsu, Yasushi Sato, Kazuyuki Murase, Junji Kato

    The Liver: Biology and Pathobiology: Fifth Edition   1121 - 1129   2009.10

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  • ヘッジホッグ・シグナル伝達阻害剤は、CD34+白血病細胞の薬剤耐性を解除する Reviewed

    菊地 尚平, 小船 雅義, 村瀬 和幸, 井山 諭, 佐藤 勉, 瀧本 理修, 河野 豊, 宮西 浩嗣, 佐藤 康史, 加藤 淳二

    臨床血液   50 ( 9 )   1113 - 1113   2009.9

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  • シクロパミンは、CD34陽性白血病細胞の薬剤耐性を解除する(Cyclopamine dramatically restores drug resistance of CD34+ leukemic cells) Reviewed

    小船 雅義, 井山 諭, 佐藤 勉, 瀧本 理修, 菊地 尚平, 村瀬 和幸, 河野 豊, 宮西 浩嗣, 佐藤 康史, 加藤 淳二

    日本癌学会総会記事   68回   480 - 480   2009.8

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  • Drug resistance is dramatically restored by hedgehog inhibitors in CD34(+) leukemic cells Reviewed

    Masayoshi Kobune, Rishu Takimoto, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Shohei Kikuchi, Yutaka Kawano, Kohji Miyanishi, Yasushi Sato, Yoshiro Niitsu, Junji Kato

    CANCER SCIENCE   100 ( 5 )   948 - 955   2009.5

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    DOI： 10.1111/j.1349-7006.2009.01111.x

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  • アデノウイルスベクターを用いたヘッジホッグ遺伝子の高発現は、TおよびBリンパ球の分化抑制を誘導する Reviewed

    加藤 淳二, 小船 雅義, 村瀬 和幸, 井山 諭, 佐藤 勉, 河野 豊, 瀧本 理修, 松永 卓也

    臨床血液   49 ( 9 )   1085 - 1085   2008.9

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  • ヒト骨髄間質細胞は臍帯血CD34陰性細胞のCXCR4発現増強と長期造血再建能を誘導する Reviewed

    小船 雅義, 村瀬 和幸, 井山 諭, 佐藤 勉, 河野 豊, 瀧本 理修, 松永 卓也, 加藤 淳二

    臨床血液   49 ( 9 )   940 - 940   2008.9

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  • Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells Reviewed

    Masayoshi Kobune, Yutaka Kawano, Sho Takahashi, Kohichi Takada, Kazuyuki Murase, Satosi Iyama, Tsutomu Sato, Rishu Takimoto, Yoshiro Niitsu, Junji Kato

    EXPERIMENTAL HEMATOLOGY   36 ( 9 )   1121 - 1131   2008.9

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    DOI： 10.1016/j.exphem.2008.04.007

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  • [A case of hepatosplenic gammadelta T-cell lymphoma associated hemophagocytic syndrome]. Reviewed

    Iyama S, Matsunaga T, Sato T, Sato Y, Sagawa T, Murase K, Kida M, Kobune M, Takimoto R, Kato J, Niitsu Y

    Gan to kagaku ryoho. Cancer & chemotherapy   35 ( 9 )   1623 - 1627   2008.9

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  • Apoptosis supercedes necrosis in mitochondrial DNA-depleted Jurkat cells by cleavage of receptor-interacting protein and inhibition of lysosomal cathepsin. Reviewed

    Sato T, Machida T, Takahashi S, Murase K, Kawano Y, Hayashi T, Iyama S, Takada K, Kuribayashi K, Sato Y, Kobune M, Takimoto R, Matsunaga T, Kato J, Niitsu Y

    Journal of immunology (Baltimore, Md. : 1950)   181 ( 1 )   197 - 207   2008.7

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  • Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Reviewed

    Sato Y, Murase K, Kato J, Kobune M, Sato T, Kawano Y, Takimoto R, Takada K, Miyanishi K, Matsunaga T, Takayama T, Niitsu Y

    Nature biotechnology   26 ( 4 )   431 - 442   2008.4

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  • [An advanced metastatic breast cancer patient successfully treated with combination therapy including docetaxel, doxorubicin and cyclophosphamide (TAC) as salvage therapy]. Reviewed

    Sato Y, Takayama T, Sagawa T, Sato T, Okamoto K, Takahashi S, Abe S, Iyama S, Murase K, Kato J, Niitsu Y

    Gan to kagaku ryoho. Cancer & chemotherapy   35 ( 3 )   471 - 473   2008.3

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  • Successful treatment of autoimmune pancreatitis complicated with autoimmune thrombocytopenia and interstitial pneumonia by prednisolone Reviewed

    Kazuyuki Murase, Takuya Matsunaga, Tsuyoshi Hayashi, Hirotoshi Ishiwatari, Naoko Araki, Satoshi Iyama, Tsutomu Sato, Masayoshi Kobune, Rishu Takimoto, Koji Miyanishi, Toru Miyazaki, Hisami Ikeda, Junji Kato, Yoshiro Niitsu

    INTERNAL MEDICINE   47 ( 11 )   1033 - 1038   2008

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    DOI： 10.2169/internalmedicine.47.0803

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  • Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate Reviewed

    Satoshi Iyama, Takuya Matsunaga, Tsutomu Sato, Kazuyuki Murase, Naoko Araki, Rishu Takimoto, Masayoshi Kobune, Tamotsu Sagawa, Tetsuji Takayama, Yoshiro Niitsu

    INTERNAL MEDICINE   47 ( 8 )   791 - 794   2008

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    DOI： 10.2169/internalmedicine.47.0714

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  • 骨髄腫から産生されるWnt3は、RhoAシグナルを活性化し、VLA6依存性CAM-DRを惹起する Reviewed

    小船 雅義, 河野 豊, 村瀬 和幸, 井山 諭, 佐藤 勉, 瀧本 理修, 松永 卓也, 加藤 淳二, 新津 洋司郎

    日本癌治療学会誌   42 ( 2 )   482 - 482   2007.9

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  • Wnt3/RhoA/ROCKシグナル伝達は多発性骨髄腫の接着介在性薬物耐性へと自己分泌性に関与する(Wnt3/RhoA/ROCK signaling is involved in adhesion-mediated drug resistance of multiple myeloma in an autocline manner) Reviewed

    小船 雅義, 井山 諭, 佐藤 勉, 瀧本 理修, 松永 卓也, 河野 豊, 村瀬 和幸, 加藤 淳二, 新津 洋司郎

    日本癌学会総会記事   66回   334 - 334   2007.8

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  • Reappearance of t(12;17)-positive primary myelofibrosis following Ph+ CML cell reduction by imatinib

    Naoko Araki, Rishu Takimoto, Akihito Fujimi, Kazuyuki Murase, Hironobu Araki, Naoki Takahira, Takuya Matsunaga, Takeshi Terui, Katsuhisa Kogawa, Yasuo Hirayama, Junji Kato, Yoshiro Niitsu

    [Rinshō ketsueki] The Japanese journal of clinical hematology   48 ( 6 )   518 - 523   2007

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  • A phase I/II study of nedaplatin and 5-fluorouracil with concurrent radiotherapy in patients with esophageal cancer Reviewed

    Yasushi Sato, Tetsuji Takayama, Tamotsu Sagawa, Tetsuro Okamoto, Koji Miyanishi, Tsutomu Sato, Hironobu Araki, Satoshi Iyama, Seiichiro Abe, Kazuyuki Murase, Rishu Takimoto, Hisayasu Nagakura, Masato Hareyama, Junji Kato, Yoshiro Niitsu

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   58 ( 5 )   570 - 576   2006.11

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    DOI： 10.1007/s00280-006-0193-x

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  • Amelioration of murine dextran sulfate sodium-induced colitis by ex vivo extracellular superoxide dismutase gene transfer. Reviewed

    Oku T, Iyama S, Sato T, Sato Y, Tanaka M, Sagawa T, Kuribayashi K, Sumiyosi T, Murase K, Machida T, Okamoto T, Matsunaga T, Takayama T, Takahashi M, Kato J, Hamada H, Niitsu Y

    Inflammatory bowel diseases   12 ( 7 )   630 - 640   2006.7

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  • 肝線維化の分子機構と治療 肝星細胞のコラーゲン特異シャペロンHSP47を標的とした肝線維化抑制療法 Reviewed

    村瀬 和幸, 加藤 淳二, 佐藤 康史, 小船 雅義, 瀧本 理修, 高田 弘一, 河野 豊, 佐藤 勉, 宮西 浩嗣, 荒木 啓伸, 新津 洋司郎

    肝臓   47 ( Suppl.1 )   A38 - A38   2006.4

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  • Human herpesvirus-6 hepatitis associated with cyclosporine-A encephalitis after bone marrow transplantation for chronic myeloid leukemia Reviewed

    Kageaki Kuribayashi, Takuya Matsunaga, Satoshi Iyama, Koichi Takada, Tsutomu Sato, Kazuyuki Murase, Akihito Fujimi, Rishu Takimoto, Johji Kawanishi, Yoshiro Niitsu

    INTERNAL MEDICINE   45 ( 7 )   475 - 478   2006

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    DOI： 10.2169/internalmedicine.45.1507

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  • [Essential thrombocythemia associated with incomplete type intestinal Behçet disease during hydroxyurea treatment]. Reviewed

    Kobune M, Kato J, Kuribayashi K, Iyama S, Fujimi A, Murase K, Ueno A, Kikuchi S, Satoh T, Okamoto T, Takimoto R, Matsunaga T, Niitsu Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   46 ( 10 )   1136 - 1140   2005.10

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  • Donor cell derived acute myeloid leukemia after allogeneic cord blood transplantation in a patient with adult T-cell lymphoma Reviewed

    T Matsunaga, K Murase, M Yoshida, A Fujimi, S Iyama, K Kuribayashi, T Sato, K Kogawa, Y Hirayama, S Sakamaki, K Kohda, Y Niitsu

    AMERICAN JOURNAL OF HEMATOLOGY   79 ( 4 )   294 - 298   2005.8

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    DOI： 10.1002/ajh.20349

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  • A Patient with TP53 Germline Mutation Developed Bowen's Disease and Myelodysplastic Syndrome with Myelofibrosis after Chemotherapy against Ovarian Cancer

    KURIBAYASHI Kageaki, MATSUNAGA Takuya, SAKAI Toshio, WADA Yuko, TATENO Kumiko, MURASE Kazuyuki, FUJIMI Akihito, TAKIMOTO Rishu, TERUI Takeshi, KATO Junji, SASAKI Aya, SATOH Masaaki, NIITSU Yoshiro

    Japanese Journal of Medicine   44 ( 5 )   490 - 495   2005.5

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    Here we report a case of myelodysplastic syndrome (MDS) with myelofibrosis associated with Bowen's disease. A female patient had undergone an operation and chemotherapy for ovarian cancer when she was 65 years old, and she developed MDS at the age of 70 years old. PCR-single strand conformation polymorphism (SSCP) analysis of peripheral blood mononuclear cells, a Bowen's disease lesion, and normal skin showed an abnormal peak in TP53 exon5. Direct sequencing revealed that they all had missense mutation in codon 175 (G to A) of arginine switched to histidine, suggesting a germline mutation of TP53. It was speculated that p53 function was lost by TP53 germline mutation with the loss of a wild type allele induced by the chemotherapy against ovarian cancer, leading to the development of MDS. No therapeutic effects of low dose melphalan or cyclosporine A on MDS were observed, however one month of 30 mg/day prednisolone administration induced a hematological response.

    Other Link： https://jlc.jst.go.jp/DN/JALC/00249907597?from=CiNii

    DOI： 10.2169/internalmedicine.44.490

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  • Successful induction and complete improvement of myelofibrosis and erythema nosodum with cladribine in a case of hairy cell leukemia

    Hironobu Araki, Takuya Matsunaga, Kazuyuki Murase, Hiroyuki Kuroda, Kageaki Kuribayashi, Takeshi Terui, Yoshiro Niitsu

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   31 ( 6 )   965 - 969   2004

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  • Allogeneic bone marrow transplantation in a patient with T-prolymphocytic leukemia with small-intestinal involvement. Reviewed

    Murase K, Matsunaga T, Sato T, Kuribayashi K, Kogawa K, Kawano Y, Okamoto T, Takayama T, Watanabe H, Niitsu Y, Hirayama Y

    International journal of clinical oncology   8 ( 6 )   391 - 394   2003.12

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  • [A case of gastric carcinoma with multiple skin, bone, and bilateral ovary metastasis; effective treatment by chemotherapy]. Reviewed

    Mezawa S, Homma H, Doi T, Akiyama T, Murakami K, Kogawa K, Hirata K, Kida M, Murase K, Iyama S

    Gan to kagaku ryoho. Cancer & chemotherapy   30   1973 - 1975   2003.11

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  • Superselective transcatheter embolization for acute lower gastrointestinal hemorrhage after endoscopic mucosal resection: A report of 3 cases Reviewed

    S Mezawa, H Homma, K Murase, T Doi, S Iyama, K Takada, K Hirata, F Mezawa, Y Niitsu

    HEPATO-GASTROENTEROLOGY   50 ( 51 )   735 - 737   2003.5

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  • リザーバー肝動注用力テーテルの十二指腸球部逸脱の１例

    高梨 訓博, 高柳 典弘, 西堀 佳樹, 藤井 重之, 堀本 正禎, 小野寺 義光, 村瀬 和幸, 古川 孝広, 長岡 康裕, 新津 洋司郎

    日本消化機病學會雜誌. 乙   100 ( 5 )   578 - 582   2003

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    症例は63歳男性. 平成10年11月直腸癌, 肝転移(S2)に対しMiles手術および肝動脈力ニュレーションを施行した. その後, 外来にて動注化学療法を持続していたところ, 平成12年の上部消化管内視鏡検査で動注用力テーテルの十二指腸球部への逸脱を認めた. その機序としては, カテーテルによる十二指腸壁の外側からの圧排, 穿破が推測された, 今後, 動注症例の増加と予後の改善による経過の長期化にともない, 同様な症例を経験することが多くなると予想され, 報告した.

    DOI： 10.11405/nisshoshi1964.100.578

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  • Implantation of a dual chambers port for hepatic and splenic arterial infusion chemotherapy in advanced pancreatic carcinoma with multiple liver metastasis

    T. Kukitsu, H. Homma, S. Iyama, T. Doi, M. Kida, S. Mezawa, K. Murase, K. Takada, K. Miyanishi, Y. Niitsu

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   28 ( 11 )   1562 - 1564   2001

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  • Hepatic and splenic arterial infusion chemotherapy after transcatheter peripancreatic arterial embolization for patients with inoperable adenocarcinoma of the pancreas

    H. Homma, T. Kukitsu, S. Mezawa, T. Doi, M. Kida, K. Miyanishi, K. Takada, K. Murase, S. Iyama, Y. Niitsu

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   28 ( 11 )   1558 - 1561   2001

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  • A study of carboplatin-coated tube for the unresectable cholangiocarcinoma Reviewed

    S Mezawa, H Homma, T Sato, T Doi, K Miyanishi, K Takada, T Kukitsu, K Murase, N Yoshizaki, M Takahashi, S Sakamaki, Y Niitsu

    HEPATOLOGY   32 ( 5 )   916 - 923   2000.11

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MISC

  • 低用量IL2はBCL2の発現を誘導することでCD4制御性T細胞のアポトーシスを抑制する(Low-close interleukin-2 induces BCL2 expression and resistance to apoptosis in CD4 regulatory T Cells)

    松野 鉄平, 村瀬 和幸, 高田 弘一, 河野 豊, 平川 昌宏, 宮西 浩嗣, 小船 雅義, 加藤 淳二

    札幌医学雑誌   87 ( 1-6 )   49 - 61   2018.12

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    Ichushi

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  • 消化器癌におけるVEGF阻害剤関連血栓症に対する直接経口抗凝固薬(DOAC)の有用性

    平川昌宏, 早坂尚貴, 佐藤昌則, 松野鉄平, 三浦省吾, 藤田千紗, 大沼啓之, 村瀬和幸, 高田弘一, 宮西浩嗣, 加藤淳二

    日本消化器病学会雑誌(Web)   115   2018

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  • P53-RESTORING SMALL MOLECULE CP-31398 INDUCES APOPTOSIS VIA INDUCTION OF REACTIVE OXIDATIVE SPECIES IN HUMAN MULTIPLE MYELOMA

    Y. Arihara, K. Takada, Y. Kawano, N. Hayasaka, H. Nakamura, S. Kikuchi, Y. Kamihara, K. Murase, H. Ikeda, S. Iyama, T. Sato, K. Miyanishi, M. Kobune, J. Kato

    HAEMATOLOGICA   102   498 - 498   2017.6

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  • Extracellular Vesicle microRNAs from Acute Myeloid Leukemia Are Involved in the Regulation of Adherence Junction in Bone Marrow Microenvironment.

    Masahiro Yoshida, Masayoshi Kobune, Shogo Miura, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato

    BLOOD   128 ( 22 )   2016.12

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  • CD34/EPO-R Double Positive MDS Cells Produce Erythroferrone in Response to Erythropoietin

    Shogo Miura, Masayoshi Kobune, Soushi Ibata, Masahiro Yoshida, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Wataru Jomen, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato

    BLOOD   128 ( 22 )   2016.12

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  • Next Generation Sequencing of CD138+Myeloma Cells Could Predict Response Rate and Appropriate Therapy at Diagnosis

    Hiroshi Ikeda, Yasushi Sasaki, Soushi Ibata, Masahiro Yoshida, Ayumi Tatekoshi, Satoshi Iyama, Kazuyuki Murase, Kohichi Takada, Shohei Kikuchi, Tsutomu Sato, Masayoshi Kobune, Junji Kato

    BLOOD   128 ( 22 )   2016.12

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  • 成人男性に発症した眼窩内原発のEwing肉腫の1例

    佐藤 圭悟, 平岡 美紀, 橋本 雅人, 山下 建, 杉田 真太朗, 長谷川 匡, 村瀬 和幸, 大黒 浩

    臨床眼科   70 ( 12 )   1773 - 1778   2016.11

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  • Trastuzumab Based Chemotherapy in Two Patients with HER2-Positive Metastatic Carcinoma ex Pleomorphic Adenoma

    Yohei Arihara, Kazuyuki Murase, Kohichi Takada, Naotaka Hayasaka, Shogo Miura, Koji Miyanishi, Masayoshi Kobune, Makoto Kurose, Yukinori Akiyama, Junji Kato

    ANNALS OF ONCOLOGY   27   2016.7

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  • A PHASE 2 TRIAL OF SMALL-DOSE BORTEZOMIB, LENALIDOMIDE, AND DEXAMETHASONE (SVRD) AS CONSOLIDATION/MAINTENANCE THERAPY IN PATIENTS WITH MULTIPLE MYELOMA

    T. Sato, H. Kuroda, Y. Nagamachi, S. Iyama, A. Fujimi, Y. Kamihara, Y. Konuma, M. Yoshida, S. Ibata, A. Tatekoshi, A. Hashimoto, H. Horiguchi, K. Ono, K. Murase, K. Takada, K. Miyanishi, M. Kobune, Y. Hirayama, J. Kato

    HAEMATOLOGICA   101   792 - 793   2016.6

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  • DEFERASIROX INDUCES APOPTOSIS THROUGH INHIBITION OF ONCOGENIC PYK2/BETA-CATENIN SIGNALING IN MULTIPLE MYELOMA CELLS

    K. Takada, Y. Kamihara, T. Sato, Y. Kawano, K. Murase, Y. Arihara, S. Kikuchi, N. Hayasaka, M. Usami, S. Iyama, K. Miyanishi, M. Kobune, J. Kato

    HAEMATOLOGICA   101   78 - 79   2016.6

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  • IL-2 Induces Selective Activation of Helios-Positive Regulatory T Cells and CD56(bright) NK Cells in Vitro and in Patients with Chronic Gvhd Receiving Low-Dose IL-2 Therapy

    Masahiro Hirakawa, Tiago R. Matos, John Koreth, Edouard Forcade, Jennifer Whangbo, Kazuyuki Murase, Hongye Liu, Sarah Nikiforow, Vincent T. Ho, Corey S. Cutler, Philippe Armand, Edwin P. Alyea, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz

    BLOOD   126 ( 23 )   2015.12

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  • 多発性骨髄腫における鉄代謝異常および鉄キレート剤による抗腫瘍効果の解析

    高田 弘一, 神原 悠輔, 佐藤 勉, 河野 豊, 井山 諭, 村瀬 和幸, 菊地 尚平, 堀口 拓人, 橋本 亜香利, 舘越 鮎美, 瀧本 理修, 小船 雅義, 加藤 淳二

    International Journal of Myeloma   5 ( 2 )   100 - 100   2015.5

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    Ichushi

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  • A phase I/II study of definitive chemoradiotherapy with docetaxel, nedaplatin, and 5-fluorouracil (DNF-R) for advanced esophageal cancer

    Yasushi Sato, Hiroyuki Ohnuma, Masahiro Hirakawa, Yutaka Okagawa, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Tamotsu Sagawa, Masakazu Hori, Masanori Someya, Koh-ichi Sakata, Tetsuji Takayama, Junji Kato

    JOURNAL OF CLINICAL ONCOLOGY   33 ( 3 )   2015.1

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  • Exosomes Derived from AML/MDS Cells Is Involved in Stromal Dysfunction and Bone Marrow Failure

    Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Wataru Jomen, Kazuyuki Murase, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Yusuke Kamihara, Koji Miyanishi, Yasushi Sato, Tsuyoshi Hayashi, Rishu Takimoto, Junji Kato

    BLOOD   124 ( 21 )   2014.12

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  • Low-Dose IL-2 Reduces Mitochondrial Priming and Increases Bcl2 Expression in CD4 Memory Regulatory T Cells

    Kazuyuki Murase, Haesook T. Kim, Masahiro Hirakawa, Tiago Reis Matos, Yutaka Kawano, Jeremy Ryan, Ken-Ichi Matsuoka, John Koreth, Robert J. Soiffer, Anthony G. Letai, Junji Kato, Jerome Ritz

    BLOOD   124 ( 21 )   2014.12

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  • Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells

    Kazuyuki Murase, Yutaka Kawano, Jeremy Ryan, Ken-ichi Matsuoka, Gregory Bascug, Sean McDonough, Robert W. Smith, Kristen Cowens, Suzan Lazo-Kallanian, John Daley, John Koreth, Robert J. Soiffer, Anthony Letai, Jerome Ritz

    BLOOD   122 ( 21 )   2013.11

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  • Regulation of Apoptotic Pathways in Human Regulatory T Cells in Chronic Graft Versus Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

    Kazuyuki Murase, Yutaka Kawano, Jeremy Ryan, Ken-ichi Matsuoka, Gregory Bascug, Sean M. McDonough, Robert Smith, Suzan Lazo-Kallanian, John Daley, John Koreth, Robert J. Soiffer, Anthony Letai, Jerome Ritz

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   19 ( 2 )   S140 - S141   2013.2

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  • Apoptotic Pathways of Human Regulatory T Cells in Chronic Graft Versus Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

    Kazuyuki Murase, Yutaka Kawano, Jeremy Ryan, Ken-ichi Matsuoka, Gregory Bascug, Sean McDonough, Robert W. Smith, Suzan Lazo-Kallanian, John Daley, John Koreth, Robert J. Soiffer, Anthony G. Letai, Jerome Ritz

    BLOOD   120 ( 21 )   2012.11

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  • RETROSPECTIVE ANALYSIS OF IFOSFAMIDE ENCEPHALOPATHY IN PATIENTS WITH BONE AND SOFT TISSUE SARCOMAS

    K. Takada, R. Takimoto, T. Yoshinaga, S. Iyama, K. Ono, K. Murase, T. Sato, K. Miyanishi, Y. Sato, M. Kobune, T. Soma, S. Nagoya, T. Yamashita, A. Watanabe, J. Kato

    ANNALS OF ONCOLOGY   23   130 - 130   2012.10

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  • P-0322 多発性骨髄腫に対するレナリドミド療法の有害事象の解析と薬剤管理指導(一般演題 ポスター発表,がん薬物療法(その他),Enjoy Pharmacists' Lifestyles)

    中村 勝之, 野田 師正, 安井 寛, 池田 博, 林 敏昭, 石田 禎夫, 篠村 恭久, 村瀬 和幸, 井山 諭, 佐藤 勉, 瀧本 理修, 小船 雅義, 加藤 淳二, 中田 浩雅, 宮本 篤

    日本医療薬学会年会講演要旨集   21   235 - 235   2011.9

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  • Case report: Two cases of myelodysplastic syndrome associated with proderma gangrenosum

    108 ( 3 )   558 - 560   2011.9

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  • A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine

    Sho Takahashi, Yasushi Sato, Tamotsu Sagawa, Shingo Tanaka, Kazuyuki Murase, Kohichi Takada, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Ganji Kuroiwa, Michiaki Hirayama, Tetsuro Okamoto, Junji Kato

    Journal of Japanese Society of Gastroenterology   108 ( 8 )   1405 - 1412   2011.8

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    DOI： 10.11405/nisshoshi.108.1405

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  • Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer

    Masahiro Hirakawa, Yasushi Sato, Hiroyuki Ohnuma, Tamotsu Sagawa, Hirotoshi Ishiwatari, Kazuyuki Murase, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

    Journal of Japanese Society of Gastroenterology   108 ( 2 )   231 - 237   2011.2

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    DOI： 10.11405/nisshoshi.108.231

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  • 抗体薬 ゲムツズマブ オゾガマイシン (分子標的治療薬--最新の選び方・使い方) -- (がん分子標的治療薬の使い方)

    佐藤 勉, 村瀬 和幸, 加藤 淳二

    がん治療レクチャー   2 ( 2 )   272 - 274   2011

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  • Treatment of liver cirrhosis with vitamin A-coupled liposomes carrying siRNA against heat shock protein 47

    65 ( 12 )   2593 - 2598   2010.12

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  • Long-Term Production System of Red Blood Cells Using Human Cord Blood and Stromal Cells.

    Masayoshi Kobune, Shohei Kikuchi, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

    BLOOD   116 ( 21 )   1317 - 1317   2010.11

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  • Expression of DNA Repair Factor DDB2 predicts chemoresistance in various cancer cell lines

    Rishu Takimoto, Kazuyuki Murase, Yoshiyuki Onuma, Masahiro Hirakawa, Makoto Yoshida, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    CANCER RESEARCH   70   2010.4

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  • Expression of DNA Repair Factor DDB2 predicts chemoresistance in various cancer cell lines

    Rishu Takimoto, Kazuyuki Murase, Yoshiyuki Onuma, Masahiro Hirakawa, Makoto Yoshida, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Junji Kato

    CANCER RESEARCH   70   2010.4

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    DOI： 10.1158/1538-7445.AM10-3936

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  • Evaluation of the Efficacy of Liposomal Amphotericin B

    IYAMA Satoshi, MURASE Kazuyuki, SATO Tsutomu, KIKUCHI Shohei, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Risyu, KATO Junji

    Kansenshogaku Zasshi   84 ( 2 )   182 - 186   2010.3

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    A retrospective study was performed to evaluate the efficacy and safety of liposomal amphotericin B (L-AMB) in a total of 32 cases who were among patients hospitalized at the Fourth Department of Internal Medicine, Sapooro Medical University from December 2006 to April 2008. Primary diagnoses were hematologic diseases in 87.5％of subjects. The most common hematologic diseases included acute myelogenous leukemia in 50％of the subjects, followed by malignant lymphoma in 12.5％of the subjects. The mean administration period was 14.2±12.9 days, and the mean cumulative dose was 1,786±2,181 mg. L-AMB improved 21 of 29 cases (72.4％) with some fungal infections or fever-associated neutropenia. Adverse events occurred in 9 cases to a slight degree, in 7 cases to a moderate degree, and in no case to a severe degree. Hypokalemia and hypercreatininemia were seen in 7 cases (21.9％) and 4 cases (12.5％), respectively, but these adverse reactions were so mild that the treatment did not need to be discontinued. Any adverse reactions for which treatment administration was discontinued were confirmed to have disappeared at the end of the study. These results support the efficacy and safety of L-AMB in accordance with previous foreign reports. It was noteworthy that early use of L-AMB prior to established diagnosis sometimes better therapeutic outcomes. It was also suggested that L-AMB could be safely administered while controlling electrolyte balance, such as serum potassium concentration, with sufficient fluid replacement, including physiological saline infusion. There are limitations in the use of the conventional form of amphotericin B because of its renal toxicity and other reasons. However, L-AMB had fewer side effects, so the agent was considered useful for the treatment of hematologic disease patients who either had mycosis or carried a risk for fungal infection.

    DOI： 10.11150/kansenshogakuzasshi.84.182

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  • Treatment of liver fibrosis with vitamin A coupled liposomes carrying HSP47siRNA

    Naoko Birukawa, Kazuyuki Murase, Yasushi Sato, Akemi Kosaka, Akihiro Yoneda, Hiroki Nishita, Naoko Kitamura, Yasunobu Tanaka, Hirokazu Takahashi, Keiko Kajiwara, Junji Kato, Yoshiro Niitsu

    JOURNAL OF PHARMACOLOGICAL SCIENCES   112   27P - 27P   2010

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  • Cyclopamine Induced Apoptosis in Primary CD34+Acute Leukemic Cells.

    Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Yasushi Sato, Junji Kato

    BLOOD   114 ( 22 )   1450 - 1450   2009.11

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  • CD34+Cobblestone Area-Forming Cells Are a Valuable Indicator to Screen the Soluble Inhibitors of Hematopoiesis in the Serum of Aplastic Anemia and MDS Patients.

    Shohei Kikuchi, Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yutaka Kawano, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

    BLOOD   114 ( 22 )   584 - 584   2009.11

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  • ACTIVATED HEPATIC STELLATE CELLS, BUT NOT QUIESCENT HEPATIC STELLATE CELLS SUSTAIN THEIR SURVIVAL BY PI3K/AKT/NFKB SIGNAL FROM COLLAGEN SECRETED BY THEMSELVES

    Naoko K. Birukawa, Kazuyuki Murase, Yasushi Sato, Hiroki Nishita, Akihiro Yoneda, Akemi Kosaka, Naoko Kitamura, Junji Kato, Yoshiro Niitsu

    HEPATOLOGY   50 ( 4 )   835A - 835A   2009.10

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  • Hedgehog Inhibitors Reduce the Survival and Drug Resistance in CD34+Leukemic Cells

    Masayoshi Kobune, Kazuyuki Murase, Satoshi Lyama, Tsutomu Sato, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Rishu Takimoto, Junji Kato

    BLOOD   112 ( 11 )   570 - 570   2008.11

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  • Interaction with Human Stromal Cells Enhances CXCR4 Expression and Engraftment of Cord Blood Lin-CD34-Cells Via Writ Signaling.

    Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Shohei Kikuchi, Yutaka Kawano, Kohichi Takada, Koji Miyanishi, Rishu Takimoto, Junji Kato

    BLOOD   112 ( 11 )   810 - 810   2008.11

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  • Wnt3 Signaling Augments integrin beta 1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner

    Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Rishu Takimoto, Junji Kato

    BLOOD   112 ( 11 )   599 - 600   2008.11

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  • 北海道における中枢神経原発悪性リンパ腫の現状

    畠山 直樹, 鈴木 信寛, 政氏 伸夫, 橋野 聡, 藤本 勝也, 村瀬 和幸, 奈良崎 亘, 照井 健, 黒田 裕行, 小林 一, 泉山 康, 木田 雅也, 進藤 基博, 佐藤 一也, 黒澤 光俊, 鈴木 佐知子, 笠井 正晴, 福原 敬

    臨床血液   49 ( 9 )   972 - 972   2008.9

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    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

    Ichushi

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  • Treatment of idiopathic myelofibrosis employing siRNA for heat shock protein 47 (siRNA/HSP47) encapsulated in liposomes

    Junichi Watanabe, Takuya Matsunaga, Kazuyuki Murase, Yasushi Sato, Taiko Nagaya, Hirotoshi Ishiwatari, Sho Takahashi, Koichi Takada, Masayoshi Kobune, Kazuya Shimoda, Mine Harada, Yoshiro Niitsu

    BLOOD   110 ( 11 )   235B - 235B   2007.11

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  • Factor XI deficiency caused by a mutation of Gly400Val

    SATO Tsutomu, IYAMA Satoshi, ARAKI Naoko, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, MATSUNAGA Takuya, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

    48 ( 2 )   148 - 150   2007.2

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    DOI： 10.11406/rinketsu.48.148

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  • Gastric relapse of stage I ocular adnexal : mucosa-associated lymphoid tissue lymphoma

    SATO Tsutomu, TAKIMOTO Rishu, IYAMA Satoshi, ONO Kaoru, TANAKA Shingo, ARAKI Naoko, NISHIIE Kiwami, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, MATSUNAGA Takuya, KATO Junji, NIITSU Yoshiro

    Rinsho Ketsueki   48 ( 1 )   56 - 60   2007.1

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    Language：Japanese   Publisher：The Japanese Society of Hematology  

    A 57-year-old male with right ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) was successfully treated with local radiation therapy. The gastroendoscopic examination revealed a slight inflammatory change of the gastric mucosa, and the urease test was positive. Eradication therapy against <i>Helicobacter pylori</i> was successfully done, however, the patient developed gastric MALT lymphoma two years after the initial treatment. Southern blot analysis of the immunoglobulin heavy chain gene rearrangement revealed that the lymphoma cells from the ocular adnexal and gastric MALT lymphomas were identical, indicating that the gastric MALT lymphoma was not the primary but the metastatic region from the ocular adnexal MALT lymphoma. Further, immunohistochemical staining demonstrated the expression of integrin &alpha;4&beta;7 on ocular adnexal MALT lymphoma cells, which is essential for the adhesion of lymphocytes to gastrointestinal mucosa. These results indicate that ocular adnexal MALT lymphoma cells can metastasize to the stomach, depending on the adhesional function of integrin &alpha;4&beta;7.

    DOI： 10.11406/rinketsu.48.56

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  • Report of an autopsy case of colon cancer with amyotrophic lateral sclerosis

    Yasushi Sato, Tetsuji Takayama, Tomomi Nikaido, Yuko Wada, Tamotsu Sagawa, Seiichiro Abe, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Hironobu Araki, Yasuhiro Sato, Junji Kato, Yoshiro Niitsu, Hideki Chiba

    Japanese Journal of Gastroenterology   104 ( 9 )   1365 - 1370   2007

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    Language：Japanese   Publisher：The Japanese Society of Gastroenterology  

    DOI： 10.11405/nisshoshi.104.1365

    PubMed

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  • Treatment of hepatic fibrosis in rat treated with dimethylnitrosamine by siRNA/HSP47 encapsulated in vitamin A conjugated liposome

    Yasushi Sato, Junji Kato, Kazuyuki Murase, Masayoshi Kobune, Tsutomu Sato, Rishu Takimoto, Takuya Matsunaga, Tetsuji Takayama, Yoshiro Niitsu

    JOURNAL OF GENE MEDICINE   8 ( 12 )   1455 - 1455   2006.12

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  • Peripheral T-cell lymphoma presenting with eosinophilia due to Interleukin-5 produced by lymphoma cells

    MATSUNAGA Takuya, SATO Tsutomu, IYAMA Satoshi, TANAKA Shingo, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

    Rinsho Ketsueki   47 ( 11 )   1457 - 1462   2006.11

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    Language：Japanese   Publisher：The Japanese Society of Hematology  

    A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.

    DOI： 10.11406/rinketsu.47.1457

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  • Enteropathy-type T-cell lymphoma with CD8 and CD56 expression

    SATO Tsutomu, MATSUNAGA Takuya, IYAMA Satoshi, SAKAI Toshiro, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, NIITSU Yoshiro

    47 ( 7 )   645 - 649   2006.7

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    DOI： 10.11406/rinketsu.47.645

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  • Enteropathy-type T-cell lymphoma with CD8 and CD56 expression

    SATO Tsutomu, MATSUNAGA Takuya, IYAMA Satoshi, SAKAI Toshiro, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, NIITSU Yoshiro

    Rinsho Ketsueki   47 ( 7 )   645 - 649   2006

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    Language：Japanese   Publisher：The Japanese Society of Hematology  

    A 54-year-old male presented at a previous hospital with abdominal pain, where the patient was diagnosed as having abdominal and retroperitoneal lymphadenopathies by CT scan, then, he was referred to our hospital for further examination. Upper gastrointestinal endoscopy showed a tumor formation in the second portion of the duodenum, and there were medium sized atypical lymphocytes in biopsy specimens of the tumor. Since the atypical lymphocytes in the biopsy specimens were positive for CD3, CD8, CD56 and CD103 by immunostain, and had a rearrangement of the T-cell receptor γ-chain, the patient was diagnosed as having enteropathy-type T-cell lymphoma (ETL). Although ETL usually occurs as a complication of celiac disease, malabsorption and anti-gliadin antibodies, which are normally present in celiac disease, were not observed in this patient.

    DOI： 10.11406/rinketsu.47.645

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  • Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient

    IYAMA Satoshi, MATSUNAGA Takuya, FUJIMI Akihito, MURASE Kazuyuki, KURIBAYASI Kageaki, SATO Tsutomu, HIRAYAMA Yasuo, SAKAMAKI Sumio, KOHDA Kyuhei, NIITSU Yoshiro

    Rinsho Ketsueki   46 ( 5 )   363 - 367   2005.5

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    Language：Japanese   Publisher：The Japanese Society of Hematology  

    A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling. Adenovirus type 11 hemorrhagic cystitis developed and progressed to nephritis and hemophagocytic syndrome. Oral ribavirin was effective not only for the hemorrhagic cystitis and nephritis but also for the hemophagocytic syndrome. Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.

    DOI： 10.11406/rinketsu.46.363

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  • Phenotypic transdifferentiation of human mesenchymal stem cells into human hepatocytes directly injected to the rat liver without evidence of fusion.

    Y Sato, H Araki, J Kato, K Murase, K Miyanishi, T Sato, T Takayama, Y Niitsu

    GASTROENTEROLOGY   128 ( 4 )   A702 - A702   2005.4

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  • 11. 臍帯血移植後にドナー細胞由来の急性骨髄性白血病(AML)を発症した成人T細胞性白血病リンパ腫(ATLL)(日本アフェレシス学会第24回北海道地方会抄録)(<特集>アフェレシスにおけるセイフティーマネジメント)

    村瀬 和幸, 松永 卓也, 栗林 景晶, 井山 諭, 菊池 尚平, 藤見 章仁, 新津 洋司郎, 古川 勝久

    日本アフェレシス学会雑誌   24 ( 1 )   121 - 121   2005.2

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  • Second hematologic response and disappearance of the ABL gene mutant clone by cessation of imatinib in a CML patient with resistance to imatinib

    MURASE Kazuyuki, MATSUNAGA Takuya, TAKEUCHI Naoko, FUJIMI Akihito, TAKIMOTO Rishu, TERUI Takeshi, HIRAYAMA Yasuo, NIITSU Yoshiro

    45 ( 9 )   1028 - 1032   2004.9

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    DOI： 10.11406/rinketsu.45.1028

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  • 当科で経験した非血縁者間ミニ移植を施行した4症例(一般演題)(日本アフェレシス学会第23回北海道地方会抄録)

    藤見 章仁, 松永 卓也, 村瀬 和幸, 竹内 直子, 高平 尚季, 二階堂 ともみ, 瀧本 理修, 新津 洋司郎

    日本アフェレシス学会雑誌   23 ( 2 )   202 - 202   2004.5

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  • Successful corticosteroid treatment of thrombocytopenia in a pregnant woman with myelodysplastic syndrome (refractory anemia)

    MURASE Kazuyuki, MATSUNAGA Takuya, TAKIMOTO Rishu, TAKAHIRA Naoki, FUJIMI Akihito, TAKEUCHI Naoko, TERUI Takeshi, NIITSU Yoshiro

    Rinsho Ketsueki   45 ( 5 )   383 - 386   2004.5

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    Language：Japanese   Publisher：The Japanese Society of Hematology  

    A 31-year-old pregnant woman was referred to our hospital due to anemia and thrombocytopenia, and was diagnosed as having myelodysplastic syndrome (refractory anemia) with autoimmune thrombocytopenia. Administration of high dose methylprednisolone and &gamma;-globulin did not raise her platelet count, and she subsequently delivered a healthy baby after the transfusion of a large amount of platelets. Although the anemia spontaneously improved after delivery, the platelet count remained unchanged. Prednisolone was thus administered a second time, which did finally increase the platelet count. This is the first reported case of a pregnant woman with myelodysplastic syndrome in whom corticosteroid administration was effective for thrombocytopenia.

    DOI： 10.11406/rinketsu.45.383

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  • Second hematologic response and disappearance of the ABL gene mutant clone by cessation of imatinib in a CML patient with resistance to imatinib

    MURASE Kazuyuki, MATSUNAGA Takuya, TAKEUCHI Naoko, FUJIMI Akihito, TAKIMOTO Rishu, TERUI Takeshi, HIRAYAMA Yasuo, NIITSU Yoshiro

    Rinsho Ketsueki   45 ( 9 )   1028 - 1032   2004

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    A seventy-six year old female patient with chronic myelogenous leukemia (CML), (chronic phase), was treated with imatinib and obtained a major cytogenetic response after 6 months of treatment. However, resistance to imatinib appeared 9 months later due to an ABL gene point mutation, and the patient&#039;s platelet count and BCR/ABL positive rate had remarkably increased. We discontinued imatinib and used IFNα or hydroxyurea, resulting in the disappearance of the ABL gene mutation clone. After that, we obtained a secondary hematologic response with the administration of imatinib.

    DOI： 10.11406/rinketsu.45.1028

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  • A case of catheter tip dislocation to the duodenal bulb for hepatic arterial infusion chemotherapy

    TAKANASHI Kunihiro, TAKAYANAGI Norihiro, NISHIHORI Yoshiki, FUJII Shigeyuki, HORIMOTO Masayoshi, ONODERA Yoshimitsu, MURASE Kazuyuki, KOGAWA Takahiro, NAGAOKA Yasuhiro, NIITSU Yoshiro

    100 ( 5 )   578 - 582   2003.5

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  • A case of polyarteritis nodosa treated by methotrexate: Follow-up study of hepatic arteriography

    Kunihiro Takanashi, Hisato Homma, Shin-Ichi Mezawa, Tadashi Doi, Takehide Akiyama, Ken Murakami, Koichi Takada, Takehiro Kukitsu, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yoshiro Niitsu

    Acta Hepatologica Japonica   44 ( 12 )   649 - 655   2003

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    Language：Japanese   Publisher：Japan Society of Hepatology  

    DOI： 10.2957/kanzo.44.649

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  • A case of pancreatic ascites due to rupture of pancreatic pseudocyst successfully treated with continuous arterial infusion of nafamostat mesilate

    DOI Tadashi, HOMMA Hisato, MEZAWA Shinichi, KIDA Masaya, KUKITSU Takehiro, MIYANISHI Kouji, MURASE Kazuyuki, TAKADA Kouichi, IYAMA Satoshi, NIITSU Youshirou

    Nippon Shokakibyo Gakkai Zasshi   98 ( 11 )   1304 - 1308   2001.11

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    Language：Japanese   Publisher：The Japanese Society of Gastroenterology  

    DOI： 10.11405/nisshoshi1964.98.1304

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