Misc - MURASE Kazuyuki

低用量IL2はBCL2の発現を誘導することでCD4制御性T細胞のアポトーシスを抑制する(Low-close interleukin-2 induces BCL2 expression and resistance to apoptosis in CD4 regulatory T Cells)

松野 鉄平, 村瀬 和幸, 高田 弘一, 河野 豊, 平川 昌宏, 宮西 浩嗣, 小船 雅義, 加藤 淳二

札幌医学雑誌 ( 札幌医科大学 )  87 ( 1-6 ) 49 - 61  2018.12

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制御性T細胞(Treg)は自己免疫寛容や恒常性の維持に重要な役割を果たしている。インターロイキン2(IL-2)はTregの増加、活動、生存に非常に重要である。既報では低用量IL-2はTregの増加に選択的に作用し、自己免疫疾患の臨床症状を改善させると報告されている。IL-2がTregの内因性アポトーシスにどのように作用するのかを調べるために、我々はBH3プロファイリングを用い、ミトコンドリアのアポトーシスプライミングを定量的に測定した。BH3ペプチドパターンではTregのプライミングがTconより多く、それがBCL2に依存していることを示した。実際に、TregではTconよりもBCL2の発現が低かった。IL-2の作用を調べるために、TregとTconに分け、異なった用量のIL-2で培養した。Tregでは低用量のIL-2(10 IU/ml)でプライミングは低下しBCL2発現は増加したが、Tconではプライミングの低下とBCL2発現の増加には高用量のIL-2(>100 IU/ml)が必要であった。また、低用量IL-2はTregにおいてのみアポトーシスへの感受性を減らすことがアポトーシスアッセイによって判明した。ABT-199というBCL2選択的阻害剤はTregとTcon両者のプライミングとアポトーシスを増加させる。IL2はTregにおいてのみこのABT-199の効果を打ち消した。このことからTregにおけるIL2による内因性アポトーシスの阻害がBCL2に依存していることが判明した。(著者抄録)

消化器癌におけるVEGF阻害剤関連血栓症に対する直接経口抗凝固薬(DOAC)の有用性

平川昌宏, 早坂尚貴, 佐藤昌則, 松野鉄平, 三浦省吾, 藤田千紗, 大沼啓之, 村瀬和幸, 高田弘一, 宮西浩嗣, 加藤淳二

日本消化器病学会雑誌(Web)   115  2018

J-GLOBAL

P53-RESTORING SMALL MOLECULE CP-31398 INDUCES APOPTOSIS VIA INDUCTION OF REACTIVE OXIDATIVE SPECIES IN HUMAN MULTIPLE MYELOMA

Y. Arihara, K. Takada, Y. Kawano, N. Hayasaka, H. Nakamura, S. Kikuchi, Y. Kamihara, K. Murase, H. Ikeda, S. Iyama, T. Sato, K. Miyanishi, M. Kobune, J. Kato

HAEMATOLOGICA ( FERRATA STORTI FOUNDATION )  102   498 - 498  2017.06

Research paper, summary (international conference)  

Next Generation Sequencing of CD138+Myeloma Cells Could Predict Response Rate and Appropriate Therapy at Diagnosis

Hiroshi Ikeda, Yasushi Sasaki, Soushi Ibata, Masahiro Yoshida, Ayumi Tatekoshi, Satoshi Iyama, Kazuyuki Murase, Kohichi Takada, Shohei Kikuchi, Tsutomu Sato, Masayoshi Kobune, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  128 ( 22 )  2016.12

Research paper, summary (international conference)  

Extracellular Vesicle microRNAs from Acute Myeloid Leukemia Are Involved in the Regulation of Adherence Junction in Bone Marrow Microenvironment.

Masahiro Yoshida, Masayoshi Kobune, Shogo Miura, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  128 ( 22 )  2016.12

Research paper, summary (international conference)  

CD34/EPO-R Double Positive MDS Cells Produce Erythroferrone in Response to Erythropoietin

Shogo Miura, Masayoshi Kobune, Soushi Ibata, Masahiro Yoshida, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Wataru Jomen, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  128 ( 22 )  2016.12

Research paper, summary (international conference)  

成人男性に発症した眼窩内原発のEwing肉腫の1例

佐藤 圭悟, 平岡 美紀, 橋本 雅人, 山下 建, 杉田 真太朗, 長谷川 匡, 村瀬 和幸, 大黒 浩

臨床眼科 ( (株)医学書院 )  70 ( 12 ) 1773 - 1778  2016.11

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目的:成人男性に発症したEwing肉腫の報告。症例:右眼に1ヵ月前から発症した充血と眼瞼腫脹で,43歳男性が受診した。3週間前から右眼の眼球突出と複視を自覚していた。所見と経過:矯正視力は右0.4,左1.0で,眼圧は右27mmHg,左19mmHgであった。右眼に眼球突出と眼瞼下垂があった。MRIで右眼窩の内上縁に35mm大の腫瘤があり,頭蓋内に延長していた。全身の画像検索で他に腫瘍はなく,眼窩に原発した腫瘍であると診断した。生検と分子学的解析でEwing肉腫と診断した。腫瘍は急速に増大し,初診から5週間後に眼球が脱出した。放射線療法で眼球は復位し,化学療法で18ヵ月後の現在まで,腫瘍の悪化はない。結論:眼窩に原発するEwing肉腫が成人に発症することは稀である。本症例では,いったん悪化した後,放射線療法と化学療法で軽快した。(著者抄録)

Trastuzumab Based Chemotherapy in Two Patients with HER2-Positive Metastatic Carcinoma ex Pleomorphic Adenoma

Yohei Arihara, Kazuyuki Murase, Kohichi Takada, Naotaka Hayasaka, Shogo Miura, Koji Miyanishi, Masayoshi Kobune, Makoto Kurose, Yukinori Akiyama, Junji Kato

ANNALS OF ONCOLOGY ( OXFORD UNIV PRESS )  27  2016.07

Research paper, summary (international conference)  

DEFERASIROX INDUCES APOPTOSIS THROUGH INHIBITION OF ONCOGENIC PYK2/BETA-CATENIN SIGNALING IN MULTIPLE MYELOMA CELLS

K. Takada, Y. Kamihara, T. Sato, Y. Kawano, K. Murase, Y. Arihara, S. Kikuchi, N. Hayasaka, M. Usami, S. Iyama, K. Miyanishi, M. Kobune, J. Kato

HAEMATOLOGICA ( FERRATA STORTI FOUNDATION )  101   78 - 79  2016.06

Research paper, summary (international conference)  

A PHASE 2 TRIAL OF SMALL-DOSE BORTEZOMIB, LENALIDOMIDE, AND DEXAMETHASONE (SVRD) AS CONSOLIDATION/MAINTENANCE THERAPY IN PATIENTS WITH MULTIPLE MYELOMA

T. Sato, H. Kuroda, Y. Nagamachi, S. Iyama, A. Fujimi, Y. Kamihara, Y. Konuma, M. Yoshida, S. Ibata, A. Tatekoshi, A. Hashimoto, H. Horiguchi, K. Ono, K. Murase, K. Takada, K. Miyanishi, M. Kobune, Y. Hirayama, J. Kato

HAEMATOLOGICA ( FERRATA STORTI FOUNDATION )  101   792 - 793  2016.06

Research paper, summary (international conference)  

IL-2 Induces Selective Activation of Helios-Positive Regulatory T Cells and CD56(bright) NK Cells in Vitro and in Patients with Chronic Gvhd Receiving Low-Dose IL-2 Therapy

Masahiro Hirakawa, Tiago R. Matos, John Koreth, Edouard Forcade, Jennifer Whangbo, Kazuyuki Murase, Hongye Liu, Sarah Nikiforow, Vincent T. Ho, Corey S. Cutler, Philippe Armand, Edwin P. Alyea, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz

BLOOD ( AMER SOC HEMATOLOGY )  126 ( 23 )  2015.12

Research paper, summary (international conference)  

多発性骨髄腫における鉄代謝異常および鉄キレート剤による抗腫瘍効果の解析

高田 弘一, 神原 悠輔, 佐藤 勉, 河野 豊, 井山 諭, 村瀬 和幸, 菊地 尚平, 堀口 拓人, 橋本 亜香利, 舘越 鮎美, 瀧本 理修, 小船 雅義, 加藤 淳二

International Journal of Myeloma ( 日本骨髄腫学会 )  5 ( 2 ) 100 - 100  2015.05

A phase I/II study of definitive chemoradiotherapy with docetaxel, nedaplatin, and 5-fluorouracil (DNF-R) for advanced esophageal cancer

Yasushi Sato, Hiroyuki Ohnuma, Masahiro Hirakawa, Yutaka Okagawa, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yutaka Kawano, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Tamotsu Sagawa, Masakazu Hori, Masanori Someya, Koh-ichi Sakata, Tetsuji Takayama, Junji Kato

JOURNAL OF CLINICAL ONCOLOGY ( AMER SOC CLINICAL ONCOLOGY )  33 ( 3 )  2015.01

Research paper, summary (international conference)  

Exosomes Derived from AML/MDS Cells Is Involved in Stromal Dysfunction and Bone Marrow Failure

Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Wataru Jomen, Kazuyuki Murase, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Yusuke Kamihara, Koji Miyanishi, Yasushi Sato, Tsuyoshi Hayashi, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  124 ( 21 )  2014.12

Research paper, summary (international conference)  

Low-Dose IL-2 Reduces Mitochondrial Priming and Increases Bcl2 Expression in CD4 Memory Regulatory T Cells

Kazuyuki Murase, Haesook T. Kim, Masahiro Hirakawa, Tiago Reis Matos, Yutaka Kawano, Jeremy Ryan, Ken-Ichi Matsuoka, John Koreth, Robert J. Soiffer, Anthony G. Letai, Junji Kato, Jerome Ritz

BLOOD ( AMER SOC HEMATOLOGY )  124 ( 21 )  2014.12

Research paper, summary (international conference)  

Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells

Kazuyuki Murase, Yutaka Kawano, Jeremy Ryan, Ken-ichi Matsuoka, Gregory Bascug, Sean McDonough, Robert W. Smith, Kristen Cowens, Suzan Lazo-Kallanian, John Daley, John Koreth, Robert J. Soiffer, Anthony Letai, Jerome Ritz

BLOOD ( AMER SOC HEMATOLOGY )  122 ( 21 )  2013.11

Research paper, summary (international conference)  

Regulation of Apoptotic Pathways in Human Regulatory T Cells in Chronic Graft Versus Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Kazuyuki Murase, Yutaka Kawano, Jeremy Ryan, Ken-ichi Matsuoka, Gregory Bascug, Sean M. McDonough, Robert Smith, Suzan Lazo-Kallanian, John Daley, John Koreth, Robert J. Soiffer, Anthony Letai, Jerome Ritz

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION ( ELSEVIER SCIENCE INC )  19 ( 2 ) S140 - S141  2013.02

Research paper, summary (international conference)  

Apoptotic Pathways of Human Regulatory T Cells in Chronic Graft Versus Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Kazuyuki Murase, Yutaka Kawano, Jeremy Ryan, Ken-ichi Matsuoka, Gregory Bascug, Sean McDonough, Robert W. Smith, Suzan Lazo-Kallanian, John Daley, John Koreth, Robert J. Soiffer, Anthony G. Letai, Jerome Ritz

BLOOD ( AMER SOC HEMATOLOGY )  120 ( 21 )  2012.11

Research paper, summary (international conference)  

RETROSPECTIVE ANALYSIS OF IFOSFAMIDE ENCEPHALOPATHY IN PATIENTS WITH BONE AND SOFT TISSUE SARCOMAS

K. Takada, R. Takimoto, T. Yoshinaga, S. Iyama, K. Ono, K. Murase, T. Sato, K. Miyanishi, Y. Sato, M. Kobune, T. Soma, S. Nagoya, T. Yamashita, A. Watanabe, J. Kato

ANNALS OF ONCOLOGY ( OXFORD UNIV PRESS )  23   130 - 130  2012.10

Research paper, summary (international conference)  

P-0322 多発性骨髄腫に対するレナリドミド療法の有害事象の解析と薬剤管理指導(一般演題 ポスター発表,がん薬物療法(その他),Enjoy Pharmacists' Lifestyles)

中村 勝之, 野田 師正, 安井 寛, 池田 博, 林 敏昭, 石田 禎夫, 篠村 恭久, 村瀬 和幸, 井山 諭, 佐藤 勉, 瀧本 理修, 小船 雅義, 加藤 淳二, 中田 浩雅, 宮本 篤

日本医療薬学会年会講演要旨集 ( 日本医療薬学会 )  21   235 - 235  2011.09

CiNii

Case report: Two cases of myelodysplastic syndrome associated with proderma gangrenosum

村瀬 和幸, 佐藤 勉, 瀧本 理修

内科 ( 南江堂 )  108 ( 3 ) 558 - 560  2011.09

CiNii

A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine

Sho Takahashi, Yasushi Sato, Tamotsu Sagawa, Shingo Tanaka, Kazuyuki Murase, Kohichi Takada, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Ganji Kuroiwa, Michiaki Hirayama, Tetsuro Okamoto, Junji Kato

Journal of Japanese Society of Gastroenterology ( The Japanese Society of Gastroenterology )  108 ( 8 ) 1405 - 1412  2011.08

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A 64-year-old man had been admitted to a previous hospital because of melena and a diagnosis of ulcerative colitis (UC, pancolitis type) had been made. He had received prednisolone and 5-ASA but steroid-induced hyperamylasemia had developed. Prednisolone had been tapered and halted, but it had resulted in UC relapse and thrombocytopenia. Then, he was referred to our hospital due to severe melena with hypovolemic shock. However, he was also positive for CMV antigen. Thus, we attempted to treat him with ganciclovir for CMV and intravenous cyclosporine (CsA) for UC. According to his clinical course, a reduction of CsA blood concentration induced leukocytopenia. Myelodysplastic syndrome (MDS, RAEB-1) was then revealed after bone marrow biopsy. A high blood CsA concentration may cause the improvement of UC and MDS conditions.

DOI PubMed CiNii

Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer

Masahiro Hirakawa, Yasushi Sato, Hiroyuki Ohnuma, Tamotsu Sagawa, Hirotoshi Ishiwatari, Kazuyuki Murase, Satoshi Iyama, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Masayoshi Kobune, Rishu Takimoto, Junji Kato

Journal of Japanese Society of Gastroenterology ( The Japanese Society of Gastroenterology )  108 ( 2 ) 231 - 237  2011.02

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A 75-year-old man received chemoradiotherapy (CRT) for stage IVa esophageal cancer and complete response (CR) was obtained. However, he was referred to our department for recurrence in an area of esophagus not included in the previously irradiated field. Left pleural effusion increased after admission. Tuberculous pleuritis was eventually diagnosed by thoracoscopic pleural biopsy. It is necessary to accurately diagnose the cause of pleural effusion after CRT, because treatment strategies greatly depend on it. It is also necessary to consider the possible onset of tuberculous pleuritis, in particular, in patients with a history of tuberculosis infection.

DOI PubMed CiNii

抗体薬 ゲムツズマブ オゾガマイシン (分子標的治療薬--最新の選び方・使い方) -- (がん分子標的治療薬の使い方)

佐藤 勉, 村瀬 和幸, 加藤 淳二

がん治療レクチャー ( 総合医学社 )  2 ( 2 ) 272 - 274  2011

CiNii

Treatment of liver cirrhosis with vitamin A-coupled liposomes carrying siRNA against heat shock protein 47

佐藤 康史, 村瀬 和幸, 新津 洋司郎

最新医学 ( 最新医学社 )  65 ( 12 ) 2593 - 2598  2010.12

CiNii

Long-Term Production System of Red Blood Cells Using Human Cord Blood and Stromal Cells.

Masayoshi Kobune, Shohei Kikuchi, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  116 ( 21 ) 1317 - 1317  2010.11

Research paper, summary (international conference)  

Expression of DNA Repair Factor DDB2 predicts chemoresistance in various cancer cell lines

Rishu Takimoto, Kazuyuki Murase, Yoshiyuki Onuma, Masahiro Hirakawa, Makoto Yoshida, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Junji Kato

CANCER RESEARCH ( AMER ASSOC CANCER RESEARCH )  70  2010.04

Research paper, summary (international conference)  

Expression of DNA Repair Factor DDB2 predicts chemoresistance in various cancer cell lines

Rishu Takimoto, Kazuyuki Murase, Yoshiyuki Onuma, Masahiro Hirakawa, Makoto Yoshida, Tsutomu Sato, Yasushi Sato, Koji Miyanishi, Masayoshi Kobune, Junji Kato

CANCER RESEARCH ( AMER ASSOC CANCER RESEARCH )  70  2010.04

Research paper, summary (international conference)  

DOI

Evaluation of the Efficacy of Liposomal Amphotericin B

IYAMA Satoshi, MURASE Kazuyuki, SATO Tsutomu, KIKUCHI Shohei, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Risyu, KATO Junji

Kansenshogaku Zasshi ( The Japanese Association for Infectious Diseases )  84 ( 2 ) 182 - 186  2010.03

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A retrospective study was performed to evaluate the efficacy and safety of liposomal amphotericin B (L-AMB) in a total of 32 cases who were among patients hospitalized at the Fourth Department of Internal Medicine, Sapooro Medical University from December 2006 to April 2008. Primary diagnoses were hematologic diseases in 87.5％of subjects. The most common hematologic diseases included acute myelogenous leukemia in 50％of the subjects, followed by malignant lymphoma in 12.5％of the subjects. The mean administration period was 14.2±12.9 days, and the mean cumulative dose was 1,786±2,181 mg. L-AMB improved 21 of 29 cases (72.4％) with some fungal infections or fever-associated neutropenia. Adverse events occurred in 9 cases to a slight degree, in 7 cases to a moderate degree, and in no case to a severe degree. Hypokalemia and hypercreatininemia were seen in 7 cases (21.9％) and 4 cases (12.5％), respectively, but these adverse reactions were so mild that the treatment did not need to be discontinued. Any adverse reactions for which treatment administration was discontinued were confirmed to have disappeared at the end of the study. These results support the efficacy and safety of L-AMB in accordance with previous foreign reports. It was noteworthy that early use of L-AMB prior to established diagnosis sometimes better therapeutic outcomes. It was also suggested that L-AMB could be safely administered while controlling electrolyte balance, such as serum potassium concentration, with sufficient fluid replacement, including physiological saline infusion. There are limitations in the use of the conventional form of amphotericin B because of its renal toxicity and other reasons. However, L-AMB had fewer side effects, so the agent was considered useful for the treatment of hematologic disease patients who either had mycosis or carried a risk for fungal infection.

DOI CiNii

Treatment of liver fibrosis with vitamin A coupled liposomes carrying HSP47siRNA

Naoko Birukawa, Kazuyuki Murase, Yasushi Sato, Akemi Kosaka, Akihiro Yoneda, Hiroki Nishita, Naoko Kitamura, Yasunobu Tanaka, Hirokazu Takahashi, Keiko Kajiwara, Junji Kato, Yoshiro Niitsu

JOURNAL OF PHARMACOLOGICAL SCIENCES ( JAPANESE PHARMACOLOGICAL SOC )  112   27P - 27P  2010

Research paper, summary (international conference)  

Cyclopamine Induced Apoptosis in Primary CD34+Acute Leukemic Cells.

Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Rishu Takimoto, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Yasushi Sato, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  114 ( 22 ) 1450 - 1450  2009.11

Research paper, summary (international conference)  

CD34+Cobblestone Area-Forming Cells Are a Valuable Indicator to Screen the Soluble Inhibitors of Hematopoiesis in the Serum of Aplastic Anemia and MDS Patients.

Shohei Kikuchi, Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yutaka Kawano, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  114 ( 22 ) 584 - 584  2009.11

Research paper, summary (international conference)  

ACTIVATED HEPATIC STELLATE CELLS, BUT NOT QUIESCENT HEPATIC STELLATE CELLS SUSTAIN THEIR SURVIVAL BY PI3K/AKT/NFKB SIGNAL FROM COLLAGEN SECRETED BY THEMSELVES

Naoko K. Birukawa, Kazuyuki Murase, Yasushi Sato, Hiroki Nishita, Akihiro Yoneda, Akemi Kosaka, Naoko Kitamura, Junji Kato, Yoshiro Niitsu

HEPATOLOGY ( JOHN WILEY & SONS INC )  50 ( 4 ) 835A - 835A  2009.10

Research paper, summary (international conference)  

Hedgehog Inhibitors Reduce the Survival and Drug Resistance in CD34+Leukemic Cells

Masayoshi Kobune, Kazuyuki Murase, Satoshi Lyama, Tsutomu Sato, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  112 ( 11 ) 570 - 570  2008.11

Research paper, summary (international conference)  

Wnt3 Signaling Augments integrin beta 1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner

Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Yutaka Kawano, Shohei Kikuchi, Koji Miyanishi, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  112 ( 11 ) 599 - 600  2008.11

Research paper, summary (international conference)  

Interaction with Human Stromal Cells Enhances CXCR4 Expression and Engraftment of Cord Blood Lin-CD34-Cells Via Writ Signaling.

Masayoshi Kobune, Kazuyuki Murase, Satoshi Iyama, Tsutomu Sato, Shohei Kikuchi, Yutaka Kawano, Kohichi Takada, Koji Miyanishi, Rishu Takimoto, Junji Kato

BLOOD ( AMER SOC HEMATOLOGY )  112 ( 11 ) 810 - 810  2008.11

Research paper, summary (international conference)  

北海道における中枢神経原発悪性リンパ腫の現状

畠山 直樹, 鈴木 信寛, 政氏 伸夫, 橋野 聡, 藤本 勝也, 村瀬 和幸, 奈良崎 亘, 照井 健, 黒田 裕行, 小林 一, 泉山 康, 木田 雅也, 進藤 基博, 佐藤 一也, 黒澤 光俊, 鈴木 佐知子, 笠井 正晴, 福原 敬

臨床血液 ( (一社)日本血液学会-東京事務局 )  49 ( 9 ) 972 - 972  2008.09

Treatment of idiopathic myelofibrosis employing siRNA for heat shock protein 47 (siRNA/HSP47) encapsulated in liposomes

Junichi Watanabe, Takuya Matsunaga, Kazuyuki Murase, Yasushi Sato, Taiko Nagaya, Hirotoshi Ishiwatari, Sho Takahashi, Koichi Takada, Masayoshi Kobune, Kazuya Shimoda, Mine Harada, Yoshiro Niitsu

BLOOD ( AMER SOC HEMATOLOGY )  110 ( 11 ) 235B - 235B  2007.11

Research paper, summary (international conference)  

Factor XI deficiency caused by a mutation of Gly400Val

SATO Tsutomu, IYAMA Satoshi, ARAKI Naoko, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, MATSUNAGA Takuya, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology   48 ( 2 ) 148 - 150  2007.02

DOI CiNii

Gastric relapse of stage I ocular adnexal : mucosa-associated lymphoid tissue lymphoma

SATO Tsutomu, TAKIMOTO Rishu, IYAMA Satoshi, ONO Kaoru, TANAKA Shingo, ARAKI Naoko, NISHIIE Kiwami, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, MATSUNAGA Takuya, KATO Junji, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  48 ( 1 ) 56 - 60  2007.01

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A 57-year-old male with right ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) was successfully treated with local radiation therapy. The gastroendoscopic examination revealed a slight inflammatory change of the gastric mucosa, and the urease test was positive. Eradication therapy against Helicobacter pylori was successfully done, however, the patient developed gastric MALT lymphoma two years after the initial treatment. Southern blot analysis of the immunoglobulin heavy chain gene rearrangement revealed that the lymphoma cells from the ocular adnexal and gastric MALT lymphomas were identical, indicating that the gastric MALT lymphoma was not the primary but the metastatic region from the ocular adnexal MALT lymphoma. Further, immunohistochemical staining demonstrated the expression of integrin α4β7 on ocular adnexal MALT lymphoma cells, which is essential for the adhesion of lymphocytes to gastrointestinal mucosa. These results indicate that ocular adnexal MALT lymphoma cells can metastasize to the stomach, depending on the adhesional function of integrin α4β7.

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Report of an autopsy case of colon cancer with amyotrophic lateral sclerosis

Yasushi Sato, Tetsuji Takayama, Tomomi Nikaido, Yuko Wada, Tamotsu Sagawa, Seiichiro Abe, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Hironobu Araki, Yasuhiro Sato, Junji Kato, Yoshiro Niitsu, Hideki Chiba

Japanese Journal of Gastroenterology ( The Japanese Society of Gastroenterology )  104 ( 9 ) 1365 - 1370  2007

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Amyotrophic lateral sclerosis (ALS) is a degenerative disease involving both upper and lower motor neurons and the pathogenesis of this disorder is still unknown. To date, few reports have suggested that motor neuron diseases may have a paraneoplastic origin. However, it is still under discussion whether ALS occurring in cancer patients is paraneoplastic. A 60-year-old man with rectal cancer (Stage IV) having multiple lung, liver and para-aortic lymph node metastases underwent anterior resection of the rectum as palliative surgery. He was referred to our hospital for adjuvant chemotherapy. Lung and lymph node metastases decreased after 2 courses of chemotherapy using CPT-11 and 5-FU/LV but liver metastases were enlarged, following up increase in CEA. Thereafter, he suffered from muscle weakness in hands, arms, and legs and results of neurophysiologic studies were compatible with primary lateral sclerosis (ALS). For second line chemotherapy, he was treated with low-dose CDDP/5-FU over 6 courses. As a result, the size the of metastatic lesions markedly reduced and CEA was decreased to the normal level. Although significant tumor reduction was observed, his neurological symptoms rapidly progressed. He died of aspiration pneumonia 8 months after onset of the disease. Autopsy revealed that his neuropathological findings were compatible with ALS, and it was thought to be the primary cause of death in the because of absence of cancer progression. In this case the neurological syndrome was not affected by cancer therapy. Thus our case does not support the hypothesis that ALS in associated with cancer and the relationship between both disorders remains uncertain.

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Treatment of hepatic fibrosis in rat treated with dimethylnitrosamine by siRNA/HSP47 encapsulated in vitamin A conjugated liposome

Yasushi Sato, Junji Kato, Kazuyuki Murase, Masayoshi Kobune, Tsutomu Sato, Rishu Takimoto, Takuya Matsunaga, Tetsuji Takayama, Yoshiro Niitsu

JOURNAL OF GENE MEDICINE ( JOHN WILEY & SONS LTD )  8 ( 12 ) 1455 - 1455  2006.12

Research paper, summary (international conference)  

Peripheral T-cell lymphoma presenting with eosinophilia due to Interleukin-5 produced by lymphoma cells

MATSUNAGA Takuya, SATO Tsutomu, IYAMA Satoshi, TANAKA Shingo, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, KURODA Hiroyuki, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  47 ( 11 ) 1457 - 1462  2006.11

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A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.

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Enteropathy-type T-cell lymphoma with CD8 and CD56 expression

SATO Tsutomu, MATSUNAGA Takuya, IYAMA Satoshi, SAKAI Toshiro, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology ( 日本臨床血液学会 )  47 ( 7 ) 645 - 649  2006.07

DOI CiNii

Enteropathy-type T-cell lymphoma with CD8 and CD56 expression

SATO Tsutomu, MATSUNAGA Takuya, IYAMA Satoshi, SAKAI Toshiro, MURASE Kazuyuki, SATO Yasushi, KOBUNE Masayoshi, TAKIMOTO Rishu, KATO Junji, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  47 ( 7 ) 645 - 649  2006

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A 54-year-old male presented at a previous hospital with abdominal pain, where the patient was diagnosed as having abdominal and retroperitoneal lymphadenopathies by CT scan, then, he was referred to our hospital for further examination. Upper gastrointestinal endoscopy showed a tumor formation in the second portion of the duodenum, and there were medium sized atypical lymphocytes in biopsy specimens of the tumor. Since the atypical lymphocytes in the biopsy specimens were positive for CD3, CD8, CD56 and CD103 by immunostain, and had a rearrangement of the T-cell receptor γ-chain, the patient was diagnosed as having enteropathy-type T-cell lymphoma (ETL). Although ETL usually occurs as a complication of celiac disease, malabsorption and anti-gliadin antibodies, which are normally present in celiac disease, were not observed in this patient.

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Successful treatment with oral ribavirin of adenovirus-associated hemophagocytic syndrome in a stem cell transplantation recipient

IYAMA Satoshi, MATSUNAGA Takuya, FUJIMI Akihito, MURASE Kazuyuki, KURIBAYASI Kageaki, SATO Tsutomu, HIRAYAMA Yasuo, SAKAMAKI Sumio, KOHDA Kyuhei, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  46 ( 5 ) 363 - 367  2005.05

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A 51-year-old woman with severe aplastic anemia underwent allogeneic peripheral blood stem cell transplantation using blood stem cells from an HLA-identical sibling. Adenovirus type 11 hemorrhagic cystitis developed and progressed to nephritis and hemophagocytic syndrome. Oral ribavirin was effective not only for the hemorrhagic cystitis and nephritis but also for the hemophagocytic syndrome. Since therapeutic strategies for adenovirus infection after hematopoietic stem cell transplantation have not been established, we present our case and discuss the therapeutic approach.

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Phenotypic transdifferentiation of human mesenchymal stem cells into human hepatocytes directly injected to the rat liver without evidence of fusion.

Y Sato, H Araki, J Kato, K Murase, K Miyanishi, T Sato, T Takayama, Y Niitsu

GASTROENTEROLOGY ( W B SAUNDERS CO )  128 ( 4 ) A702 - A702  2005.04

Research paper, summary (international conference)  

11. 臍帯血移植後にドナー細胞由来の急性骨髄性白血病(AML)を発症した成人T細胞性白血病リンパ腫(ATLL)(日本アフェレシス学会第24回北海道地方会抄録)(<特集>アフェレシスにおけるセイフティーマネジメント)

村瀬 和幸, 松永 卓也, 栗林 景晶, 井山 諭, 菊池 尚平, 藤見 章仁, 新津 洋司郎, 古川 勝久

日本アフェレシス学会雑誌 ( 日本アフェレシス学会 )  24 ( 1 ) 121 - 121  2005.02

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Second hematologic response and disappearance of the ABL gene mutant clone by cessation of imatinib in a CML patient with resistance to imatinib

MURASE Kazuyuki, MATSUNAGA Takuya, TAKEUCHI Naoko, FUJIMI Akihito, TAKIMOTO Rishu, TERUI Takeshi, HIRAYAMA Yasuo, NIITSU Yoshiro

臨床血液 = The Japanese Journal of Clinical Hematology ( 日本臨床血液学会 )  45 ( 9 ) 1028 - 1032  2004.09

DOI CiNii

当科で経験した非血縁者間ミニ移植を施行した4症例(一般演題)(日本アフェレシス学会第23回北海道地方会抄録)

藤見 章仁, 松永 卓也, 村瀬 和幸, 竹内 直子, 高平 尚季, 二階堂 ともみ, 瀧本 理修, 新津 洋司郎

日本アフェレシス学会雑誌 ( 日本アフェレシス学会 )  23 ( 2 ) 202 - 202  2004.05

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Successful corticosteroid treatment of thrombocytopenia in a pregnant woman with myelodysplastic syndrome (refractory anemia)

MURASE Kazuyuki, MATSUNAGA Takuya, TAKIMOTO Rishu, TAKAHIRA Naoki, FUJIMI Akihito, TAKEUCHI Naoko, TERUI Takeshi, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  45 ( 5 ) 383 - 386  2004.05

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A 31-year-old pregnant woman was referred to our hospital due to anemia and thrombocytopenia, and was diagnosed as having myelodysplastic syndrome (refractory anemia) with autoimmune thrombocytopenia. Administration of high dose methylprednisolone and γ-globulin did not raise her platelet count, and she subsequently delivered a healthy baby after the transfusion of a large amount of platelets. Although the anemia spontaneously improved after delivery, the platelet count remained unchanged. Prednisolone was thus administered a second time, which did finally increase the platelet count. This is the first reported case of a pregnant woman with myelodysplastic syndrome in whom corticosteroid administration was effective for thrombocytopenia.

DOI CiNii

Second hematologic response and disappearance of the ABL gene mutant clone by cessation of imatinib in a CML patient with resistance to imatinib

MURASE Kazuyuki, MATSUNAGA Takuya, TAKEUCHI Naoko, FUJIMI Akihito, TAKIMOTO Rishu, TERUI Takeshi, HIRAYAMA Yasuo, NIITSU Yoshiro

Rinsho Ketsueki ( The Japanese Society of Hematology )  45 ( 9 ) 1028 - 1032  2004

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A seventy-six year old female patient with chronic myelogenous leukemia (CML), (chronic phase), was treated with imatinib and obtained a major cytogenetic response after 6 months of treatment. However, resistance to imatinib appeared 9 months later due to an ABL gene point mutation, and the patient's platelet count and BCR/ABL positive rate had remarkably increased. We discontinued imatinib and used IFNα or hydroxyurea, resulting in the disappearance of the ABL gene mutation clone. After that, we obtained a secondary hematologic response with the administration of imatinib.

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A case of catheter tip dislocation to the duodenal bulb for hepatic arterial infusion chemotherapy

TAKANASHI Kunihiro, TAKAYANAGI Norihiro, NISHIHORI Yoshiki, FUJII Shigeyuki, HORIMOTO Masayoshi, ONODERA Yoshimitsu, MURASE Kazuyuki, KOGAWA Takahiro, NAGAOKA Yasuhiro, NIITSU Yoshiro

日本消化器病學會雜誌 = The Japanese journal of gastro-enterology   100 ( 5 ) 578 - 582  2003.05

DOI CiNii

A case of polyarteritis nodosa treated by methotrexate: Follow-up study of hepatic arteriography

Kunihiro Takanashi, Hisato Homma, Shin-Ichi Mezawa, Tadashi Doi, Takehide Akiyama, Ken Murakami, Koichi Takada, Takehiro Kukitsu, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yoshiro Niitsu

Acta Hepatologica Japonica ( Japan Society of Hepatology )  44 ( 12 ) 649 - 655  2003

DOI CiNii

A case of pancreatic ascites due to rupture of pancreatic pseudocyst successfully treated with continuous arterial infusion of nafamostat mesilate

DOI Tadashi, HOMMA Hisato, MEZAWA Shinichi, KIDA Masaya, KUKITSU Takehiro, MIYANISHI Kouji, MURASE Kazuyuki, TAKADA Kouichi, IYAMA Satoshi, NIITSU Youshirou

Nippon Shokakibyo Gakkai Zasshi ( The Japanese Society of Gastroenterology )  98 ( 11 ) 1304 - 1308  2001.11

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症例はアルコール性慢性膵炎を指摘されている66歳の男性．慢性膵炎の急性増悪の経過中に形成された膵仮性嚢胞の破綻による膵性腹水を発症した．経皮的腹腔ドレナージ，絶食，メシル酸ナファモスタットの経静脈投与などの保存的治療を行ったが内膵液痩が持続し，膵炎の遷延も認められたことからメシル酸ナファモスタットの持続動注療法を施行したところ膵性腹水は消失した．メシル酸ナファモスタット持続動注による膵炎の鎮静化によって内膵液痩の修復が促進されたものと考えられた．

DOI CiNii