Details of a Researcher - NISHIDA Sachiyo

Papers - NISHIDA Sachiyo

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Challenges and implications of dual employment among physicians in Japan

Sachiyo Nishida, Emiko Usui, Emi Akizuki, Ryuta Kamekura, Marie Ogawa, Kazufumi Tsuchihashi, Naoya Masumori

Discover Health Systems ( Springer Science and Business Media LLC ) 4 ( 1 ) 2025.04

DOI

Motherhood penalty for female physicians in Japan: evidence from a medical school's alumni data.

Sachiyo Nishida, Emiko Usui, Takashi Oshio, Naoya Masumori, Kazufumi Tsuchihashi

BMC health services research 24 ( 1 ) 1183 - 1183 2024.10 [International journal]

BACKGROUND: Female physicians with children often work fewer hours and take fewer shifts due to additional family responsibilities. This can contribute to a gender pay gap in the medical profession. However, limited research in Japan has quantitatively examined the factors contributing to this gap. This study aims to address this gap in the literature. METHODS: We analyzed the alumni data from a medical school in Hokkaido, Japan, for 260 physicians (198 males and 62 females). We used multivariable regression models to identify factors influencing earnings from medical practice, with a focus on gender, work schedules, parenthood, and any career interruptions related to childcare. RESULTS: Our analysis revealed a 25.0% earnings gap between male and female physicians. Nearly all female physicians with children experienced career interruptions due to childcare, while this was uncommon for male physicians. When these childcare-related interruptions were factored in, the gender pay gap narrowed by 9.7%. After adjusting for work schedules and specialty choices, female physicians with children still earned 37.2% less than male physicians, while those without children earned only 4.4% less. This suggests that motherhood is a significant driver of the gender pay gap among physicians. CONCLUSIONS: These findings highlight the negative impact of motherhood on female physicians' earnings. This emphasizes the need for policy measures to mitigate the disadvantages faced by mothers in the medical profession.

DOI PubMed

Japanese female urologists' work‐life balance during the COVID‐19 pandemic

Sachiyo Nishida, Hitomi Sasaki, Yoshiko Maeda, Masayuki Koyama, Katsuhito Miyazawa, Naoya Masumori

International Journal of Urology 2022.12

DOI

Dilemma of physician-mothers faced with an increased home burden and clinical duties in the hospital during the COVID-19 pandemic.

Sachiyo Nishida, Kanna Nagaishi, Masayo Motoya, Ayako Kumagai, Noriko Terada, Ai Kasuga, Narumi Kubota, Kotoe Iesato, Motonobu Kimizuka, Satsuki Miyajima, Masayuki Koyama, Hirofumi Ohnishi, Eichi Narimatsu, Naoya Masumori, Kazufumi Tsuchihashi, Taiji Tsukamoto, Yoshihisa Tsuji

PloS one 16 ( 6 ) e0253646 2021 [International journal]

Authorship： Lead author

PURPOSE: Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly across the world. During the pandemic, physicians in our hospital have had to respond both to the issue of treating the patients and the increasing domestic burden associated with social disruption. The purpose of this study was to assess how much the burden on our doctors, especially female doctors, was increasing. MATERIAL AND METHODS: The Physicians' Career Support Committee in Sapporo Medical University conducted a questionnaire survey. The questionnaire inquired about a wide range of subjects with regard to working style and family life during the first and second waves of the COVID-19 pandemic, and was sent to all medical/dental physicians working in Sapporo Medical University. RESULTS: A total of 266 (42.7%) physicians in our hospital responded to our questionnaire and the data for 264 data were analyzed. The total numbers of males, females, and others, including those who did not want to specify, were 178 (67.4%), 82 (31.0%), and 4 (1.5%), respectively. Among them, 62 (23.5%) and 23 (8.7%) answered that their domestic burden was slightly or markedly increased. The increase in the domestic burden showed a significant difference between genders (p = 0.04). Even after correction for background differences using multivariate analysis, being female (p<0.001), having child dependents (p<0.001), and treating COVID-19 patients (p = 0.03) were significantly related to an increased domestic burden. Regarding family style, 58.1% of the physician-fathers were from two-income families (i.e., families with both parents in employment), and they answered that their partner mainly cared for the children. In contrast, 97.3% of physician-mothers were from two-income families, and 94.6% of the physician-mothers had to take care of children by themselves. CONCLUSION: Physician-mothers are caught in a dilemma between an increased home burden and clinical duties in the hospital, with a significantly higher ratio than physician-fathers during the pandemic. As we showed, female doctors could have not continued their careers and take responsible positions in the same way as male doctors. This is a social risk in the timing of a crisis, such as a pandemic.

DOI PubMed

Expression of hepatocyte growth factor in prostate cancer may indicate a biochemical recurrence after radical prostatectomy.

Sachiyo Nishida, Yoshihiko Hirohashi, Toshihiko Torigoe, Masanori Nojima, Ryuta Inoue, Hiroshi Kitamura, Toshiaki Tanaka, Hiroko Asanuma, Noriyuki Sato, Naoya Masumori

Anticancer research 35 ( 1 ) 413 - 8 2015.01 [International journal]

Authorship： Lead author

We previously found that prostate cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) express hepatocyte growth factor (HGF) and that the HGF/c-MET proto-oncogene product (c-MET) signal has a role in the maintenance of prostate CSCs/CICs in an autocrine fashion. HGF is, thus, a novel marker for prostate CSCs/CICs. We hypothesized that high expression of HGF might be related to early recurrence of prostate cancer after radical prostatectomy, and the purpose of the present study was to evaluate the relationship between expression of HGF in prostate tissues and biochemical recurrence after radical prostatectomy. One hundred-one patients with prostate cancer who underwent open or laparoscopic radical prostatectomy from November 2008 to October 2011 with an adequate prostate-specific antigen (PSA) follow-up period, were investigated. Immunohistochemical staining of HGF was compared to biochemical recurrence after radical prostatectomy. Patients with tumors exhibiting HGF positivity of 5% or more had a significantly shorter biochemical recurrence-free period than that of patients whose tumor HGF positivity was less than 5% (p=0.001). In multivariate Cox regression, preoperative PSA and HGF positivity were independent predictors of biochemical recurrence following prostatectomy. Our finding suggests a direct link between expression of HGF, a novel prostate marker of CSCs/CICs, and biochemical recurrence after radical prostatectomy in patients with prostate cancer.

PubMed

Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor.

Sachiyo Nishida, Yoshihiko Hirohashi, Toshihiko Torigoe, Ryuta Inoue, Hiroshi Kitamura, Toshiaki Tanaka, Akari Takahashi, Hiroko Asanuma, Naoya Masumori, Taiji Tsukamoto, Noriyuki Sato

Cancer science 104 ( 4 ) 431 - 6 2013.04 [International journal]

Authorship： Lead author

Prostate cancer cells include a small population of cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) that have roles in initiation and progression of the cancer. Recently, we isolated prostate CSCs/CICs as aldehyde dehydrogenase 1-highh (ALDH1(high) ) cells using the ALDEFLUOR assay; however, the molecular mechanisms of prostate CSCs/CICs are still elusive. Prostate CSCs/CICs were isolated as ALDH1(high) cells using the ALDEFLUOR assay, and the gene expression profiles were analyzed using a cDNA microarray and RT-PCR. We found that prostate CSCs/CICs expressed higher levels of growth factors including hepatocyte growth factor (HGF). Hepatocyte growth factor protein expression was confirmed by enzyme linked immunosorbent assay and Western blotting. On the other hand, c-MET HGF receptor was expressed in both CSCs/CICs and non-CSCs/CICs at similar levels. Hepatocyte growth factor and the supernatant of myofibloblasts derived from the prostate augmented prostasphere formation in vitro, and prostasphere formation was inhibited by an anti-HGF antibody. Furthermore, c-MET gene knockdown by siRNA inhibited the prostasphere-forming ability in vitro and tumor-initiating ability in vivo. Taken together, the results indicate that HGF secreted by prostate CSCs/CICs and prostate myofibroblasts has a role in the maintenance of prostate CSCs/CICs in an autocrine and paracrine fashion.

DOI PubMed

Gene expression profiles of prostate cancer stem cells isolated by aldehyde dehydrogenase activity assay.

Sachiyo Nishida, Yoshihiko Hirohashi, Toshihiko Torigoe, Hiroshi Kitamura, Akari Takahashi, Naoya Masumori, Taiji Tsukamoto, Noriyuki Sato

The Journal of urology 188 ( 1 ) 294 - 9 2012.07 [International journal]

Authorship： Lead author

PURPOSE: Prostate cancer cells include a small population of cancer stem-like/cancer initiating cells, which have roles in cancer initiation and progression. Recently aldehyde dehydrogenase activity was used to isolate stem cells of various cancer and normal cells. We evaluated the aldehyde dehydrogenase activity of the human prostate cancer cell line 22Rv1 (ATCC®) with the ALDEFLUOR® assay and determined its potency as prostate cancer stem-like/cancer initiating cells. MATERIALS AND METHODS: The human prostate cancer cell line 22Rv1 was labeled with ALDEFLUOR reagent and analyzed by flow cytometry. ALDH1(high) and ALDH1(low) cells were isolated and tumorigenicity was evaluated by xenograft transplantation into NOD/SCID mice. Tumor sphere forming ability was evaluated by culturing in a floating condition. Invasion capability was evaluated by the Matrigel™ invasion assay. Gene expression profiling was assessed by microarrays and reverse transcriptase-polymerase chain reaction. RESULTS: ALDH1(high) cells were detected in 6.8% of 22Rv1 cells, which showed significantly higher tumorigenicity than ALDH1(low) cells in NOD/SCID mice (p < 0.05). Gene expression profiling revealed higher expression of the stem cell related genes PROM1 and NKX3-1 in ALDH1(high) cells than in ALDH1(low) cells. ALDH1(high) cells also showed higher invasive capability and sphere forming capability than ALDH1(low) cells. CONCLUSIONS: Results indicate that cancer stem-like/cancer initiating cells are enriched in the ALDH1(high) population of the prostate cancer cell line 22Rv1. This approach may provide a breakthrough to further clarify prostate cancer stem-like/cancer initiating cells. To our knowledge this is the first report of cancer stem-like/cancer initiating cells of 22Rv1 using the aldehyde dehydrogenase activity assay.

DOI PubMed

Treatment-Induced Gene Expression Changes in Metastatic Renal Cell Carcinoma: Insights from a Syngeneic Mouse Model

Ko Okabe, Toshiaki Tanaka, Tetsuya Shindo, Yuki Kyoda, Sachiyo Nishida, Kohei Hashimoto, Ko Kobayashi, Naoya Masumori

Current Oncology 2025.07

DOI

Management of apalutamide‐induced rash with focus on early peaks

Kohei Hashimoto, Tetsuya Shindo, Sachiyo Nishida, Ko Kobayashi, Toshiaki Tanaka, Naoya Masumori

International Journal of Urology 2025.01

DOI

Tumor-infiltrating CD8+ T cells recognize a heterogeneously expressed functional neoantigen in clear cell renal cell carcinoma.

Masahiro Matsuki, Yoshihiko Hirohashi, Munehide Nakatsugawa, Aiko Murai, Terufumi Kubo, Shinichi Hashimoto, Serina Tokita, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Sachiyo Nishida, Toshiaki Tanaka, Hiroshi Kitamura, Naoya Masumori, Toshihiko Torigoe

Cancer immunology, immunotherapy : CII 71 ( 4 ) 905 - 918 2022.04 [International journal]

Immune checkpoint inhibitors (ICIs) are used in cancer immunotherapy to block programmed death-1 and cytotoxic T-lymphocyte antigen 4, but the response rate for ICIs is still low and tumor cell heterogeneity is considered to be responsible for resistance to immunotherapy. Tumor-infiltrating lymphocytes (TILs) have an essential role in the anti-tumor effect of cancer immunotherapy; however, the specificity of TILs in renal cell carcinoma (RCC) is elusive. In this study, we analyzed a 58-year-old case with clear cell RCC (ccRCC) with the tumor showing macroscopic and microscopic heterogeneity. The tumor was composed of low-grade and high-grade ccRCC. A tumor cell line (1226 RCC cells) and TILs were isolated from the high-grade ccRCC lesion, and a TIL clone recognized a novel neoantigen peptide (YVVPGSPCL) encoded by a missense mutation of the tensin 1 (TNS1) gene in a human leukocyte antigen-C*03:03-restricted fashion. The TNS1 gene mutation was not detected in the low-grade ccRCC lesion and the TIL clone did not recognized low-grade ccRCC cells. The missense mutation of TNS1 encoding the S1309Y mutation was found to be related to cell migration by gene over-expression. These findings suggest that macroscopically and microscopically heterogenous tumors might show heterogenous gene mutations and reactivity to TILs.

DOI PubMed

High aldehyde dehydrogenase 1 activity is related to radiation resistance due to activation of AKT signaling after insulin stimulation in prostate cancer.

Takahito Wakamiya, Yoshihiko Hirohashi, Aiko Murai, Junko Yanagawa, Yuka Mizue, Terufumi Kubo, Shinichi Hashimoto, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Sachiyo Nishida, Yasuo Kohjimoto, Isao Hara, Toshihiko Torigoe

Biochemical and biophysical research communications 590 117 - 124 2022.01 [International journal]

The association between type 2 diabetes mellitus and prostate cancer is still under investigation, and the relationship between hyperinsulinemia and prostate cancer stem-like cells (CSCs) is elusive. Here, we investigated the function of insulin/AKT signaling in prostate CSCs. We isolated prostate CSCs as aldehyde dehydrogenase 1-high (ALDH1high) cells from the human prostate cancer 22Rv1 cell line using an ALDEFLUOR assay and established several ALDH1high and ALDH1low clones. ALDH1high clones showed high ALDH1 expression which is a putative CSC marker; however, they showed heterogeneity regarding tumorigenicity and resistance to radiation and chemotherapy. Interestingly, all ALDH1high clones showed lower phosphorylated AKT (Ser473) (pAKT) levels than the ALDH1low clones. PI3K/AKT signaling is a key cell survival pathway and we analyzed radiation resistance under AKT signaling activation by insulin. Insulin increased pAKT levels in ALDH1high and ALDH1low cells; the fold increase rate of pAKT was higher in ALDH1high cells than in ALDH1low cells. Insulin induced resistance to radiation and chemotherapy in ALDH1high cells, and the increased levels of pAKT induced by insulin were significantly related to radiation resistance. These results suggest that ALDH1 suppresses baseline pAKT levels, but AKT can be activated by insulin, leading to treatment resistance.

DOI PubMed

風の時代の働き方改革〜第1部 COVID-19感染拡大が泌尿器科医に与えた影響

西田幸代, 小山雅之, 木村友和, 吉川武志, 川崎麻己, 増田朋子, 小林知子, 山本恭代, 松本富美, 松下千枝, 前田佳子, 高橋さゆり, 佐々木ひと美, 久米春喜, 舛森直哉, 宮澤克人, 日本泌尿器科学会ダイバーシティ推進委員会

日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 ) 109回 2021.12

Neuregulin-1-β1 and γ-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells.

Masahiro Matsuki, Ryuta Inoue, Aiko Murai, Terufumi Kubo, Shinichi Hashimoto, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Sachiyo Nishida, Toshiaki Tanaka, Hiroshi Kitamura, Naoya Masumori, Yoshihiko Hirohashi, Toshihiko Torigoe

Biochemical and biophysical research communications 552 128 - 135 2021.05 [International journal]

Previously, we investigated gene expression in a high aldehyde dehydrogenase 1 expression (ALDH1high) population of urothelial carcinoma (UC) cells as UC cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) and found that NRG1 expression was upregulated in ALDH1high cells. NRG1 is a trophic factor that contains an epidermal growth factor (EGF)-like domain that signals by stimulating ERBB receptor tyrosine kinases and the cytoplasmic domain. NRG1 has been determined to be involved in frequent gene fusions with other partners in several malignancies and has a role in carcinogenesis through the NRG1 EGF-like domain and its cognitive receptor ERBBs. We thus aimed to elucidate the function of NRG1 in UC CSCs/CICs in this study. Both NRG1α and NRG1-β1 were preferentially expressed in ALDH1high cells compared with ALDH1low cells; however, siRNA experiments revealed that NRG1-β1 but not NRG1-α has a role in sphere formation. The EGF-like domain of NRG1 had a role in sphere formation of UC cells to some extent but was not essential. The intracellular domain of NRG1 did not have a role in sphere-formation. Inhibition of γ-secretase suppressed sphere formation. These findings indicate that cleavage of NRG1-β1 by γ-secretase plays an important role in UC CSC/CIC proliferation; however, the downstream targets of NRG1-β1 remain elusive.

DOI PubMed

[Promotion of Diversity in the Academic Field of Urology : Analysis of 10,000 Articles Published in Acta Urologica Japonica during a 65-Year Period].

Takashi Kobayashi, Hiroshi Tamura, Shusuke Hiragi, Sachiyo Nishida, Mieko Miyagawa, Tomohiro Kuroda, Osamu Ogawa

Hinyokika kiyo. Acta urologica Japonica 67 ( 4 ) 125 - 132 2021.04 [Domestic journal]

Gender equality is one of the most important issues in the promotion of diversity. The participation status of female urologists in academic activities has not been clarified. In the present study, we analyzed a total of 10,288 articles published by 58,914 authors in Acta Urologica Japonica since the first issue in 1955 to the present. The author's gender was determined by an application program interface for gender estimation in combination with independent manual confirmation by two researchers. The increasing rate (⊿person/⊿year) of female authors was as low as 0.067 in 1955-79, but increased to 0.400 in 1980-2000 and 0.814 in 2001-20. Over the time periods, the annual total numbers of female authors (person/year) showed an increasing trend from 3.2 in 1955-79 to 16.3 in 1980-2000 and 26.0 in 2001-20. The numbers of female author individuals, the ratio of female authors to all authors and the ratio of publications by female first author to all publications also showed similar trends. These results suggest that gender equality is becoming more prevalent in the academic field of urology. The methods and data of this study are considered to be useful for the promotion of gender equality in the academic field of urology for the future.

DOI PubMed

[A Case of Prostate Cancer with Multiple Bone Metastasis with High FGF23 Value Indicated by Intractable Hypocalcemia and Hypophosphatemia].

Sachiyo Nishida, Ikumi Shigesawa, Satoshi Nagai, Naoki Itoh, Naoya Masumori

Hinyokika kiyo. Acta urologica Japonica 67 ( 1 ) 47 - 51 2021.01 [Domestic journal]

Authorship： Lead author

A 53-year-old man was diagnosed with prostate cancer with multiple bone metastasis. Therefore androgen deprivation therapy was initiated. After treatment with denosumab injection for bone metastasis, hypocalcemia and hypophosphatemia occurred. Despite treatment for hypocalcemia with vitamin D and calcium lactate,his serum calcium and phosphate levels were refractory to treatment. The etiology of hypophosphatemia was investigated,and the level of serum fibroblast growth factor 23 (FGF23) was abnormally elevated. Three months after the first measurement of FGF23,the patient died of prostate cancer. Severe hypophosphatemia is a typical manifestation of tumor-induced hypophosphatemic osteomalacia (TIO),which is a paraneoplastic condition, mediated by FGF23 overexpression in most cases. His osteoblastic metastasis,however,did not meet the disease criteria of osteomalacia. Several reports have suggested that excessive FGF23 may mediate both severe hypophosphatemia and aggressive castrationresistant prostate cancer characteristics. Management of serum FGF23 may be a novel therapeutic strategy for castration-resistant prostate cancer with hypophosphatemia.

DOI PubMed

GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis.

Ryuta Inoue, Yoshihiko Hirohashi, Hiroshi Kitamura, Sachiyo Nishida, Aiko Murai, Akari Takaya, Eri Yamamoto, Masahiro Matsuki, Toshiaki Tanaka, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Noriyuki Sato, Naoya Masumori, Toshihiko Torigoe

Oncotarget 8 ( 17 ) 28826 - 28839 2017.04 [International journal]

Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) are small sub-population of cancer cells that are endowed with higher tumor-initiating ability, self-renewal ability and differentiation ability. CSCs/CICs could be isolated as high aldehyde dehydrogenase 1 activity cells (ALDH1high) from various cancer samples. In this study, we isolated urothelial carcinoma CSCs/CICs as ALDHhigh cells and investigated the molecular aspects. ALDH1high cells showed greater sphere-forming ability and higher tumor-initiating ability in immune-deficient mice than those of ALDH1low cells, indicating that CSCs/CICs were enriched in ALDH1high cells. cDNA microarray analysis revealed that an ionotropic glutamate receptor glutamate receptor, ionotropic, kainate 2 (GRIK2) was expressed in ALDH1high cells at a higher level than that in ALDH1low cells. GRIK2 gene knockdown by siRNAs decreased the sphere-forming ability and invasion ability, whereas GRIK2 overexpression increased the sphere-forming ability, invasion ability and tumorigenicity, indicating that GRIK2 has a role in the maintenance of CSCs/CICs. Immunohistochemical staining revealed that higher levels of GRIK2 and ALDH1 expression were related to poorer prognosis in urinary tract carcinoma cases. The findings indicate that GRIK2 has a role in the maintenance of urothelial CSCs/CICs and that GRIK2 and ALDH1 can be prognosis prediction markers for urinary tract carcinomas.

DOI PubMed

Clinical significance of adding 3 Tesla MRI to the algorithm for decision making on neurovascular bundle preservation in radical prostatectomy.

Tetsuya Shindo, Hiroshi Kitamura, Ko Kobayashi, Kohei Hashimoto, Sachiyo Nishida, Mitsuharu Tamakawa, Yuriko Kawaai, Naoya Masumori

Japanese journal of clinical oncology 46 ( 11 ) 1026 - 1030 2016.11 [International journal]

OBJECTIVES: The aim of this study was to evaluate the additional benefit of 3 Tesla magnetic resonance imaging for neurovascular bundle preservation in radical prostatectomy. METHODS: We retrospectively evaluated patients who underwent 3 T magnetic resonance imaging followed by radical prostatectomy from April 2010 through February 2014 in our university. A total of 50 patients (100 prostate sides) were included in the study. The algorithm previously we described and magnetic resonance imaging findings were considered for the decision on neurovascular bundle preservation. A tumor adjacent to the neurovascular bundle or with extracapsular extension of a posterolateral lesion of the prostate on magnetic resonance imaging was considered a contraindication for nerve-sparing radical prostatectomy. Two experienced radiologists evaluated the magnetic resonance imaging findings. Patients who received neoadjuvant hormonal therapy were excluded. All patients underwent ultrasound-guided prostate biopsy with at least 10 cores. RESULTS: Overall, 60 of the 100 neurovascular bundles were preserved according to an algorithm that consisted of the clinical stage, prostate specific antigen, Gleason score and a positive biopsy core in the apex of the prostate. Considering magnetic resonance imaging findings together with the algorithm, six neurovascular bundles were not preserved. The accuracy of predicting a positive surgical margin only by the algorithm was 56 of 60 neurovascular bundle (93.3%). When adding magnetic resonance imaging, the accuracy was 50 of 54 neurovascular bundle (92.3%). CONCLUSIONS: 3 T magnetic resonance imaging provided no additional benefit to our algorithm for neurovascular bundle preservation.

DOI PubMed

男女共同参画活動の現状と今後日本泌尿器科学会としての男女共同参画への取り組み

松下千枝, 小島聡子, 佐々木ひと美, 鈴木啓悦, 那須保友, 西田幸代, 前田佳子, 山本新吾, 吉川羊子, 中川由紀, 荒井陽一, 日本泌尿器科学会男女共同参画委員会

日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 ) 104回 PPS12 - 4 2016.04

女性泌尿器科医師を取り巻く環境とキャリア形成における課題男女共同参画委員会アンケート調査結果に基づいて

高橋さゆり, 中島のぶよ, 那須保友, 松下千枝, 西田幸代, 前田佳子, 中川由紀, 吉川羊子, 高橋悟, 赤倉功一郎, 荒井陽一, 日本泌尿器科学会男女共同参画委員会

日本泌尿器科学会雑誌 ( (一社)日本泌尿器科学会 ) 106 ( 4 ) np1 - np9 2015.10

女性泌尿器科医師を取り巻く就労環境とキャリア形成における課題を検討するため、2010年と2014年にアンケート調査を行った。調査項目は女性泌尿器科医師の背景、婚姻状況、男女差別、セクシャル・ハラスメントの現状、労働環境と出産・育児の現状、出産・育児・介護辺の希望と現状、支援の希望と現状およびキャリア志向であった。2010年は171名、2014年は233名から得られた回答を集計・解析した結果、女性差別の問題や出産育児に伴う就労問題の現状が明らかとなった。男性医師と比較して女性医師のニーズや希望は多様で、ライフステージによっても様々に変化していくことから、一人ひとりの意志を尊重した社会的支援が必要であり、女性医師だけでなく男性医師も含めたワークライフバランスの改善が望まれると考えられた。

女性泌尿器科医師の育児・出産に関する就労環境と課題

日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 ) 103回 679 - 679 2015.04

女性泌尿器科医師の就労・キャリア形成における問題の検討

日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 ) 103回 679 - 679 2015.04

[Cancer stem cells in prostate cancer].

Sachiyo Nishida, Naoya Masumori

Nihon rinsho. Japanese journal of clinical medicine 72 ( 12 ) 2229 - 33 2014.12 [Domestic journal]

The cancer stem cell (CSC) hypothesis shows that tumors contain a reservoir of self-renewing cells that maintain the tumor. Such cancer cells were first identified in leukemia in the 1990s. These cells appear to be resistant to various therapies and can survive to repopulate the tumor. Therefore, this concept has important therapeutic implications for recurrence and metastasis. In this review, we introduce the CSC hypothesis and the origin, method of identification and functions of prostate CSCs. In addition, we review the therapeutic challenges of targeting prostate CSCs.

PubMed

西田幸代, 舛森直哉

日本臨床 ( (株)日本臨床社 ) 72 ( 12 ) 2229 - 2233 2014.12

女性泌尿器外科医を支援するために JUA男女共同参画委員会の活動に向けて女性泌尿器科医支援の新たな展開

中川由紀, 荒井陽一, 赤倉功一郎, 高橋さゆり, 高橋悟, 中島のぶよ, 那須保友, 西田幸代, 前田佳子, 松下千枝, 吉川羊子

日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 ) 102回 392 - 392 2014.04

ALDH1活性で分離した前立腺癌幹細胞の特徴と成長因子の自己分泌機構

西田幸代, 廣橋良彦, 鳥越俊彦, 田中俊明, 北村寛, 舛森直哉, 佐藤昇志, 塚本泰司

泌尿器外科 ( 医学図書出版(株) ) 27 ( 2 ) 259 - 259 2014.02

ALDH1活性分析により分離された前立腺癌幹細胞集団の特徴とその遺伝子発現

西田幸代, 鳥越俊彦, 廣橋良彦, 北村寛, 舛森直哉, 佐藤昇志, 塚本泰司

泌尿器外科 ( 医学図書出版(株) ) 26 ( 12 ) 1855 - 1855 2013.12

Autocrine HGF/c-MET signaling in prostate cancer stem-like cells/cancer-initiating cells. Prostate adenocarcinoma tissue was stained by anti-SOX2 and anti-HGF antibodies. HGF is expressed in prostate adenocarcinoma tissue

Sachiyo Nishida, Yoshihiko Hirohashi, Toshihiko Torigoe, Ryuta Inoue, Hiroshi Kitamura, Toshiaki Tanaka, Akari Takahashi, Hiroko Asanuma, Naoya Masumori, Taiji Tsukamoto, Noriyuki Sato

Cancer Science ( Wiley ) 104 ( 4 ) April cover - April cover 2013.04

DOI

前立腺がん幹細胞におけるhepatocyte-growth factor(HGF)の自己分泌機構

西田幸代, 鳥越俊彦, 廣橋良彦, 井上隆太, 田中俊明, 北村寛, 高橋あかり, 舛森直哉, 塚本泰司, 佐藤昇志

日本病理学会会誌 ( (一社)日本病理学会 ) 102 ( 1 ) 346 - 346 2013.04

北海道における女性医師支援の現状

西田幸代

日本泌尿器科学会雑誌 ( (一社)日本泌尿器科学会 ) 104 ( 2 ) 182 - 182 2013.03

Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma

Hiroshi Kitamura, Toshihiko Torigoe, Yoshihiko Hirohashi, Hiroko Asanuma, Ryuta Inoue, Sachiyo Nishida, Toshiaki Tanaka, Naoya Masumori, Noriyuki Sato, Taiji Tsukamoto

VIRCHOWS ARCHIV ( SPRINGER ) 462 ( 1 ) 101 - 107 2013.01 [Refereed]

Survivin, a member of the inhibitor of apoptosis protein gene family, inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localization of survivin could predict survival of patients with upper urinary tract urothelial carcinoma (UUTUC). Immunohistochemical staining for survivin was carried out on archival specimens from 125 consecutive patients with UUTUC who underwent radical nephroureterectomy. Nuclear and cytoplasmic staining of survivin was scored and compared with clinicopathologic features and cancer-specific survival (CSS). Nuclear expression of survivin was significantly correlated with tumor grade (p<0.001), lymphovascular invasion (p=0.022) and poor survival with an estimated 5-year CSS probability of 54 % for tumors with nuclear expression of survivin vs. 73 % for those without nuclear expression of survivin (hazard ratio=2.19; 95 % confidence interval=1.02-4.70; p=0.043). The 5-year cancer-specific survival rates of patients with cytoplasmic survivin-negative and -positive tumors were 66 and 67%, respectively. There was no difference in survival between patients with cytoplasmic survivin-negative tumors and those with cytoplasmic survivin-positive tumors. Using univariate analysis, nuclear survivin expression, tumor grade, pathological T stage, pathological N stage, and lymphovascular invasion were the predictive variables for CSS. In contrast, cytoplasmic survivin expression had no prognostic relevance. These data suggest that nuclear accumulation of survivin represents biologic aggressiveness and that nuclear survivin is a negative prognostic marker in patients with resected UUTUC.

DOI PubMed

Prognostic impact of the expression of ALDH1 and SOX2 in urothelial cancer of the upper urinary tract

Hiroshi Kitamura, Toshihiko Torigoe, Yoshihiko Hirohashi, Hiroko Asanuma, Ryuta Inoue, Sachiyo Nishida, Toshiaki Tanaka, Fumimasa Fukuta, Naoya Masumori, Noriyuki Sato, Taiji Tsukamoto

Modern Pathology ( 1 ) 26 ( 1 ) 117 - 124 2013.01 [Refereed]

Aldehyde dehydrogenase 1 (ALDH1) and sex determining region-Y-related high mobility group box 2 (SOX2) have been identified as putative cancer stem-like cell/tumor-initiating cell markers in various cancer tissues. The aim of this study was to elucidate the prognostic impact of these putative cancer stem-like cell/tumor-initiating cell markers in upper urinary tract urothelial cell carcinoma. Immunohistochemical staining for ALDH1 and SOX2 was carried out on archival specimens from 125 patients with upper urinary tract urothelial cell carcinoma who underwent radical nephroureterectomy. The prognostic value of ALDH1 and SOX2 expression and other clinicopathological features was evaluated. On univariate analysis, tumor grade, pathological T stage, pathological N stage, lymphovascular invasion, ALDH1 expression and SOX2 expression were associated with a poor prognosis. On multivariate analysis, the independent factors of prognosis were tumor grade (P=0.014), pathological N stage (P=0.005) and ALDH1 expression (P=0.002). In subgroup analysis, those subgroups with no positive, one positive or two positive results in immunohistochemistry for ALDH1 and SOX2 expression had estimated 5-year cancer-specific survival rates of 80%, 49% and 22%, respectively (P< 0.001). Neither ALDH1 nor SOX2 expression correlated with intravesical recurrence after radical nephroureterectomy. These findings suggest that cancer stem-like cells/tumor-initiating cells are linked to more aggressive behavior of upper urinary tract urothelial cell carcinoma, supporting the current cancer stem cell hypothesis. Thus, therapeutic targeting of cancer stem-like cells/tumor-initiating cells in upper urinary tract urothelial cell carcinoma is a future possibility. © 2013 USCAP, Inc.

DOI PubMed

Potential survival benefit of anti-apoptosis protein: Survivin-derived peptide vaccine with and without interferon alpha therapy for patients with advanced or recurrent urothelial cancer - Results from phase i clinical trials

Toshiaki Tanaka, Hiroshi Kitamura, Ryuta Inoue, Sachiyo Nishida, Akari Takahashi-Takaya, Sachiyo Kawami, Toshihiko Torigoe, Yoshihiko Hirohashi, Taiji Tsukamoto, Noriyuki Sato, Naoya Masumori

Clinical and Developmental Immunology 2013 262967 2013 [Refereed]

We previously identified a human leukocyte antigen (HLA)-A24-restricted antigenic peptide, survivin-2B80-88, a member of the inhibitor of apoptosis protein family, recognized by CD8+cytotoxic T lymphocytes (CTL). In a phase I clinical trial of survivin-2B80-88 vaccination for metastatic urothelial cancer (MUC), we achieved clinical and immunological responses with safety. Moreover, our previous study indicated that interferon alpha (IFNα) enhanced the effects of the vaccine for colorectal cancer. Therefore, we started a new phase I clinical trial of survivin-2B80-88 vaccination with IFNα for MUC patients. Twenty-one patients were enrolled and no severe adverse event was observed. HLA-A24/survivin-2B80-88 tetramer analysis and ELISPOT assay revealed a significant increase in the frequency of the peptide-specific CTLs after vaccination in nine patients. Six patients had stable disease. The effects of IFNα on the vaccination were unclear for MUC. Throughout two trials, 30 MUO patients received survivin-2B80-88 vaccination. Patients receiving the vaccination had significantly better overall survival than a comparable control group of MUO patients without vaccination (P = 0.0009). Survivin-2B80-88 vaccination may be a promising therapy for selected patients with MUC refractory to standard chemotherapy. This trial was registered with UMIN00005859. © 2013 Toshiaki Tanaka et al.

DOI PubMed

腹腔鏡手術の技術向上に経尿道的手術および開放手術の経験はどの程度寄与するか? LapVRを用いて

西田幸代, 北村寛, 舛森直哉, 塚本泰司

泌尿器外科 ( 医学図書出版(株) ) 25 ( 10 ) 2075 - 2075 2012.10

当科における複数の分子標的薬使用経験

西田幸代, 北村寛, 高橋聡, 舛森直哉, 塚本泰司

泌尿器外科 ( 医学図書出版(株) ) 25 ( 9 ) 1906 - 1906 2012.09

下肢静脈瘤を伴う患者における術前深部静脈超音波検査の意義

西田幸代, 北村寛, 高橋聡, 舛森直哉, 塚本泰司

泌尿器外科 ( 医学図書出版(株) ) 25 ( 9 ) 1895 - 1895 2012.09

前立腺癌幹細胞におけるHGF autocrineシステム(Prostate cancer stem-like cells/ cancer initiating cells have an autocrine system of Hepatocyte Growth Factor)

西田幸代, 廣橋良彦, 鳥越俊彦, 田中俊明, 北村寛, 高橋あかり, 舛森直哉, 塚本泰司, 佐藤昇志

日本癌学会総会記事 ( 日本癌学会 ) 71回 244 - 244 2012.08

ALDH1活性分析により分離された前立腺癌幹細胞集団の特徴とその遺伝子発現

西田幸代, 鳥越俊彦, 廣橋良彦, 北村寛, 舛森直哉, 佐藤昇志, 塚本泰司

日本泌尿器科学会雑誌 ( (一社)日本泌尿器科学会 ) 103 ( 2 ) 461 - 461 2012.03

Prostate cancer detection by prebiopsy 3.0-Tesla magnetic resonance imaging.

Sachiyo Nishida, Hidefumi Kinoshita, Takao Mishima, Hiroaki Kurokawa, Noriko Sakaida, Tadashi Matsuda

International journal of urology : official journal of the Japanese Urological Association 18 ( 9 ) 653 - 8 2011.09 [International journal]

OBJECTIVES: The diagnostic value of 3.0-Tesla magnetic resonance imaging (MRI) for prostate cancer remains to be determined. The aim of the present study was to assess the features of prostate cancer detectable by prebiopsy 3.0-Tesla MRI. METHODS: From January 2007 through to December 2008, 116 patients who were examined by prebiopsy 3.0-Tesla MRI underwent radical prostatectomy for localized prostate cancer. Prostate specimens were examined to see whether the largest cancer area was the same as the area indicated on the MRI. Univariate and multivariate logistic regression analyses were conducted to identify variables predictive of agreement between MRI and histopathological findings. RESULTS: Sixty-six (56.9%) patients were suspected of having prostate cancer on the basis of MRI findings. In 49 of these patients (74.2%), it was considered that there was agreement between the abnormal area on the MRI and the index tumor. Univariate analysis revealed that there were significant differences in abnormal digital rectal examination, capsular penetration, the diameter of the index tumor of the radical prostatectomy specimen, and the Gleason scores of the biopsy and radical prostatectomy specimens. Multivariate analysis revealed that the Gleason score of the radical prostatectomy specimen was associated with the accurate detection of the prostate cancer by MRI (P = 0.0177). CONCLUSIONS: In conclusion, 3.0-Tesla MRI tends to accurately diagnose prostate cancer with high tumor burden and aggressiveness. Multimodal examination (T2-weighted imaging, dynamic contrast-enhanced imaging, and diffusion-weighted imaging) is recommended for the diagnosis of prostate cancer using 3.0-Tesla MRI.

DOI PubMed

ALDH activity assayにより同定された前立腺癌幹細胞の特徴(Prostate cancer stem cells isolated by ALDH activity assay)

西田幸代, 鳥越俊彦, 廣橋良彦, 北村寛, 舛森直哉, 塚本泰司, 佐藤昇志

日本癌学会総会記事 ( 日本癌学会 ) 70回 355 - 355 2011.09

腹腔鏡手術手技に経尿道的および開放手術の経験は寄与するか? 内視鏡手術トレーニングシミュレータを用いて

西田幸代, 舛森直哉, 塚本泰司

Japanese Journal of Endourology ( (一社)日本泌尿器内視鏡学会 ) 24 ( 2 ) 289 - 295 2011.09

これまで経尿道的手術や開放手術の経験が腹腔鏡手術手技に役立つか明らかではなかった。当科医師14名(うち腹腔鏡経験なし11名)を対象とし腹腔鏡手術の評価に有用と言われているバーチャルリアリティシステム(VRシステム)を用い各タスク(ペグの移動、カッティング、クリッピング、癒着剥離、胆嚢摘出術)の成績と、過去の経尿道的および開放手術経験数との関係を検討した。1回目では過去の手術経験はVRシステムで評価した腹腔鏡手術手技と関連したため、腹腔鏡手術の開始に当たっては各種手術経験があることが望ましいと考えられた。一方、2回目以降では過去の手術経験数とタスクの成績は相関しなかったため、VRシステムによるトレーニングが過去の経験の少なさを補う可能性があると考えられた。(著者抄録)

大腿骨頸部骨折における前立腺癌内分泌治療の臨床的意義

西田幸代, 立木仁, 長汐亮, 田仲紀明

泌尿器外科 ( 医学図書出版(株) ) 24 ( 1 ) 120 - 120 2011.01

腹腔鏡手術の技術向上に経尿道的手術および開放手術の経験はどの程度寄与するか? LapVRを用いて

西田幸代, 北村寛, 舛森直哉, 塚本泰司

Japanese Journal of Endourology and ESWL ( (一社)日本泌尿器内視鏡学会 ) 23 ( 3 ) 248 - 248 2010.10

腹腔鏡下根治的前立腺摘除術における術中迅速診断の意義

西田幸代, 河源, 木下秀文, 松田公志

Japanese Journal of Endourology and ESWL ( (一社)日本泌尿器内視鏡学会 ) 23 ( 1 ) 112 - 115 2010.04

2006年1月から2008年8月までに当科で施行した167例の腹腔鏡下根治的前立腺摘除術のなかで、術中迅速病理診断(IFS;intra operative frozen section)を行った100例についてretrospectiveに検討した。IFSで癌陽性だった症例は18例(18.0%)であった。提出部位別に見ると、膀胱頸部の提出頻度が38.6%と他部位に比べ高かった。一方、尿道の提出頻度は17.6%であるものの、癌陽性率は28.6%と最も高く、尿道断端の切除の意義についてさらに検討を重ねる必要があると考えられた。(著者抄録)

尿管ポリープに合併した尿管重積の1例

西田幸代, 河源, 井上貴昭, 大口尚基, 木下秀文, 松田公志

泌尿器科紀要 ( 泌尿器科紀要刊行会 ) 56 ( 3 ) 192 - 192 2010.03

OP-149 膀胱癌に対する拡大骨盤リンパ節郭清術における転移分布の検討(膀胱腫瘍/手術1,一般演題口演,第98回日本泌尿器科学会総会)

北村寛, 武居史泰, 西田幸代, 村中貴之, 舛森直哉, 塚本泰司

日本泌尿器科学会雑誌 ( 一般社団法人日本泌尿器科学会 ) 101 ( 2 ) 270 - 270 2010

DOI CiNii

腹腔鏡下腎・腎尿管手術において開放移行となった症例の臨床的特徴

西田幸代, 舛森直哉, 高橋聡, 伊藤直樹, 塚本泰司

Japanese Journal of Endourology and ESWL ( (一社)日本泌尿器内視鏡学会 ) 22 ( 3 ) 223 - 223 2009.11

Urethral mobility at catheter removal predicts early recovery of urinary continence after radical prostatectomy.

Sachiyo Nishida, Noriaki Utsunomiya, Hiroyuki Nishiyama, Toshiyuki Kamoto, Osamu Ogawa, Hidefumi Kinoshita

International journal of urology : official journal of the Japanese Urological Association 16 ( 4 ) 375 - 8 2009.04 [International journal]

OBJECTIVES: To analyze the clinical parameters correlated with early recovery of urinary continence after radical prostatectomy, focusing especially on urethral mobility during voiding at catheter removal. METHODS: At the time of catheter removal, a voiding cystourethrography was performed in 58 men (median age 69 years, range 55-76) who had undergone radical prostatectomy. The vertical length of urethral movement between voiding and standstill was measured.The correlation between continence status and various clinical parameters, including age, prostate volume, International Prostate Symptom Score, quality of life score and the length of urethral movement was analyzed. RESULTS: An inverse correlation was observed between length of urethral movement and urinary incontinence volume rate (defined as [leakage volume/daily total urine volume] x 100%) on day 7 after catheter removal (r = -0.388, P < 0.05). Classifying patients into two groups according to the length of urethral movement of 2 mm gave the best accuracy for the prediction of postoperative recovery of urinary incontinence with receiver operating characteristic analysis. A statistically significant difference was observed between group 1 (length >or=2 mm) and group 2(<2 mm) for the leakage rate until day 7 after the catheter was removed (P < 0.01). Urethral movement at the time of catheter removal was significantly correlated with early recovery of continence in the two groups (P < 0.05). CONCLUSIONS: Urethral mobility after radical prostatectomy, which can be easily evaluated using voiding cystourethrography, may be a good predictor of early recovery of urinary continence.

PubMed

前立腺全摘術施行症例の生検前MRI所見と全摘標本の比較検討

西田幸代, 木下秀文, 井上貴昭, 谷口久哲, 三島崇生, 増田朋子, 矢西正明, 大口尚基, 河源, 松田公志

日本泌尿器科学会雑誌 ( (一社)日本泌尿器科学会 ) 100 ( 2 ) 416 - 416 2009.02

OP-397 腹腔鏡下前立腺全摘術後の下部尿路症状の検討(前立腺腫瘍/腹腔鏡手術2,一般演題口演,第97回日本泌尿器科学会総会)

大口尚基, 三島崇生, 谷口久哲, 井上貴昭, 増田朋子, 矢西正明, 西田幸代, 河源, 木下秀文, 松田公志

日本泌尿器科学会雑誌 ( 一般社団法人日本泌尿器科学会 ) 100 ( 2 ) 288 - 288 2009

DOI CiNii

PP-225 評価用紙を用いた術者と指導者による腹腔鏡手術技術評価(体腔鏡/その他,一般演題ポスター,第97回日本泌尿器科学会総会)

吉田健志, 井上貴昭, 谷口久哲, 三島崇生, 増田朋子, 矢西正明, 西田幸代, 大口尚基, 河源, 木下秀文, 松田公志

日本泌尿器科学会雑誌 ( 一般社団法人日本泌尿器科学会 ) 100 ( 2 ) 373 - 373 2009

DOI CiNii

VP-013 Intrafascial Nerve Sparing techniqueによる腹腔鏡下前立腺全摘出術の初期経験(一般ビデオ「前立腺・後腹膜」,一般演題ビデオ,第97回日本泌尿器科学会総会)

木下秀文, 河源, 三島崇生, 谷口久哲, 増田朋子, 矢西正明, 井上貴昭, 西田幸代, 大口尚基, 松田公志

日本泌尿器科学会雑誌 ( 一般社団法人日本泌尿器科学会 ) 100 ( 2 ) 312 - 312 2009

DOI CiNii

腹腔鏡下前立腺全摘除術における術中迅速診断の有用性

西田幸代, 木下秀文, 井上貴昭, 谷口久哲, 三島崇生, 矢西正明, 増田朋子, 大口尚基, 河源, 松田公志

Japanese Journal of Endourology and ESWL ( (一社)日本泌尿器内視鏡学会 ) 21 ( 4 ) 198 - 198 2008.11

関西医大における前立腺多数ヶ所生検の臨床的検討

西田幸代, 木下秀文, 三島崇生, 谷口久哲, 井上貴昭, 矢西正明, 増田朋子, 大口尚基, 河源, 松田公志

日本癌治療学会誌 ( (一社)日本癌治療学会 ) 43 ( 2 ) 704 - 704 2008.10

転移性腎細胞癌に対し天然型IFNαの製剤変更後1年以上の寛解を得た2症例

西田幸代, 五十嵐学, 立木仁

臨床泌尿器科 ( (株)医学書院 ) 62 ( 8 ) 621 - 624 2008.07

転移性腎癌に対し天然型IFNαの製剤変更を行い,効果の得られた2症例を経験した。変更理由は,それぞれ転移巣増大と副作用である皮膚病変の出現だった。変更後転移巣は増大なく,また皮膚病変は出現せず,いずれも1年以上寛解状態にあった。近年,IFNα製剤間の抗腫瘍効果・副作用の違いに関する報告が増えているが,それぞれの患者に対し,より適切なIFNαが存在する可能性があると考えられた。(著者抄録)

Adrenocortical carcinoma: retrospective study of 14 patients experienced at a single institution over 34 years.

Sachiyo Nishida, Naoki Itoh, Takumi Sasao, Naoya Masumori, Keisuke Taguchi, Taiji Tsukamoto

International journal of urology : official journal of the Japanese Urological Association 14 ( 7 ) 581 - 4 2007.07 [International journal]

Authorship： Lead author

OBJECTIVE: To review clinical outcome of patients with adrenocortical carcinoma experienced at a single institute over 34 years. METHODS: The study included 14 patients who were diagnosed as having the disease and were treated at the Department of Urology, Sapporo Medical University Hospital between 1973 and 2006. Their clinical features and outcomes were reviewed. RESULTS: Of the 14 patients, there were nine men and five women. The median follow-up period was 13.0 months (range, 1-213). Two patients were classified as having stage II disease, seven as stage III and five as stage IV. The disease was completely removed in eight patients and incompletely in three. Two other patients received exploratory laparotomy only. The remaining one patient had no indication for surgery. The median survival periods were 2 months in patients with stage IV and 108 months in those with stages II and III (P = 0.136). Mitotane treatment in the adjuvant setting did not clearly affect the clinical courses of patients without metastasis. However, the treatment was effective for metastasis that was repeatedly developed as late recurrence in one patient. Three patients with metastasis at diagnosis received combination chemotherapy with etoposide, doxorubicin and cisplatin (EDP) with or without mitotane treatment, to which lung metastasis completely responded in one patient. CONCLUSIONS: Adrenocortical carcinoma is a rare disease but frequently recurs. The best chance of survival may be achieved by early detection and complete surgical removal. There may be patients who possibly benefit from mitotane treatment with or without EDP, although this remains to be conclusively determined.

PubMed

OP-100 PSA2-4ng/mlで施行した根治的前立腺摘除術23例の臨床的検討(第95回日本泌尿器科学会総会)

西田幸代, 進藤哲哉, 前鼻健志, 宮本慎太郎, 村中貴之, 鈴木一弘, 柳瀬雅弘

日本泌尿器科学会雑誌 ( 一般社団法人日本泌尿器科学会 ) 98 ( 2 ) 315 - 315 2007

DOI CiNii

[Clinical course of patients with negative initial prostate biopsy].

Sachiyo Nishida, Naoya Masumori, Fumimasa Fukuta, Atsushi Takahashi, Naoki Itoh, Taiji Tsukamoto

Hinyokika kiyo. Acta urologica Japonica 52 ( 7 ) 523 - 6 2006.07 [Domestic journal]

Of 227 men with a negative initial biopsy, the clinical course of 99 men who could be regularly followed using prostate specific antigen (PSA) determination was retrospectively analyzed. A repeat biopsy was recommended if the men showed persistent elevation of PSA > 10 ng/ml, PSA velocity (PSAV) > 0.75 ng/ml/year, or persistent abnormality on digital rectal examination and/or transrectal ultrasonography. A repeat biopsy was performed on 43 men. Because of the indication for a repeat biopsy, the PSAV of the 43 men who received a repeat biopsy was higher than that of the 56 men who did not. Clinically organ-confined cancer was detected in 18 patients (detection rate 41.9%). The patients having cancer had a higher PSAV (median 1.950) than those without the disease (median 0.900). Of 19 men aged 75 years and older at the initial biopsy, a repeat biopsy revealed organ-confined cancers in 4 out of 10 men. During follow-up of the 19 elderly men, 11 developed co-morbid illnesses such as cerebral infarction, ischemic heart diseases and other malignancies, and 4 died of the diseases. Thus, PSAV seems to be the best parameter for a repeat biopsy. Elderly men may not benefit from a repeat biopsy because they are unlikely to have lethal prostate cancer and highly likely to develop co-morbid illness that would affect their life-span.

PubMed

MP-097 シリコン製腎盂バルーンカテーテルにおけるバルーン自然収縮現象(一般演題ポスター,第94回日本泌尿器科学会総会)

西田幸代, 舛森直哉, 久滝俊博, 国島康晴, 高橋敦, 伊藤直樹, 塚本泰司

日本泌尿器科学会雑誌 ( 一般社団法人日本泌尿器科学会 ) 97 ( 2 ) 391 - 391 2006

DOI CiNii

初回経直腸的前立腺生検にて悪性所見を認めなかった症例の臨床経過(第93回日本泌尿器科学会総会)

西田幸代, 舛森直哉, 福多史昌, 久滝俊博, 北村寛, 松川雅則, 高橋敦, 伊藤直樹, 塚本泰司

日本泌尿器科学会雑誌 ( 一般社団法人日本泌尿器科学会 ) 96 ( 2 ) 299 - 299 2005

DOI CiNii

腎癌との鑑別が困難であった腎門部Schwannomaの1例

西田幸代, 木下秀文, 沖波武, 国島康晴, 清川岳彦, 伊藤哲之, 山本新吾, 賀本敏行, 羽渕友則, 小川修

泌尿器科紀要 ( 泌尿器科紀要刊行会 ) 50 ( 6 ) 445 - 447 2004.06

58歳女.心窩部痛を主訴に受診した.血液生化学検査,尿検査とも異常を認めなかった.腹部造影CT検査で,左腎門部に突出し,不均一な造影効果のある腫瘍を認めた.MRI検査で腫瘍は,T1強調画像で低信号,T2強調画像では高信号を呈し,造影MRI検査で周囲に不均一な増強効果を認めた.腎細胞癌と診断し,腹腔鏡下根治的腎摘除術を施行した.HE染色で紡錘型の細胞の増殖が認められ,Schwannomaと診断したが,核異型,クロマチン濃縮,核分裂像などの悪性所見は認められなかった.術後経過は良好で再発を認めない

[A case of schwannoma in the renal hilum].

Sachiyo Nishida, Hidefumi Kinoshita, Takeshi Okinami, Yasuharu Kunishima, Takehiko Segawa, Noriyuki Ito, Shingo Yamamoto, Toshiyuki Kamoto, Tomonori Habuchi, Osamu Ogawa

Hinyokika kiyo. Acta urologica Japonica 50 ( 6 ) 445 - 7 2004.06 [Domestic journal]

A 58-year-old female presented with a well-encapsulated tumor in the left renal hilum on computed tomography (CT). On magnetic resonance imaging (MRI), the tumor showed low intensity on the T1-weighted image, high intensity on the T2-weighted image. Laparoscopic radical nephrectomy was performed because we could not exclude the possibility of malignancy such as renal cell carcinoma. Histopathological examination revealed that the tumor was a benign Schwannoma. Although renal hilum is a common site of renal schwannoma, it is difficult to differentiate benign tumors from malignant ones, and then nephrectomy is usually performed.

PubMed

排尿時膀胱尿道造影による根治的前立腺全摘除術後尿失禁の予測

西田幸代, 木下秀文, 清川岳彦, 伊藤哲也, 山本新吾, 賀本敏行, 羽渕友則, 小川修

泌尿器科紀要 ( 泌尿器科紀要刊行会 ) 50 ( 5 ) 378 - 378 2004.05

泌尿器科領域における周術期感染症多施設共同研究

山本新吾, 国島康晴, 西田幸代, 中西真一, 清水洋祐, 高橋毅, 東新, 清川岳彦, 西山博之, 伊藤哲之, 木下秀文, 賀本敏行, 小川修

日本泌尿器科学会雑誌 ( (一社)日本泌尿器科学会 ) 95 ( 2 ) 428 - 428 2004.03

前立腺全摘除術後施行した排尿時膀胱尿道造影の有用性

西田幸代, 木下秀文, 高橋毅, 東新, 清川岳彦, 西山博之, 伊藤哲之, 山本新吾, 賀本敏行, 羽渕友則, 小川修

日本泌尿器科学会雑誌 ( (一社)日本泌尿器科学会 ) 95 ( 2 ) 552 - 552 2004.03

PP2-024 膀胱癌膀胱全摘症例における上部尿路腫瘍再発に関する臨床的検討(一般演題(ポスター))

中西真一, 西山博之, 西田幸代, 清水洋佑, 東新, 木下秀文, 山本新吾, 賀本敏行, 小川修