Papers - YAMAMOTO Masaki

Carbamazepine-induced hemolytic and aplastic crises associated with reduced glutathione peroxidase activity of erythrocytes.

Masaki Yamamoto, Nobuhiro Suzuki, Naoki Hatakeyama, Noriaki Kubo, Nobutada Tachi, Hitoshi Kanno, Hisaichi Fujii, Hiroyuki Tsutsumi

International journal of hematology   86 ( 4 ) 325 - 8  2007.11  [Domestic journal]

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Although pure red cell aplasia is a well-known side effect of carbamazepine treatment, intravascular hemolytic anemia is rare. We describe a 5-year-old boy who developed concurrent intravascular hemolytic anemia and erythroblastopenia, probably due to carbamazepine. Carbamazepine treatment was subsequently discontinued, and the patient was treated with red blood cell transfusions, haptoglobin, and methylprednisolone. His hematologic abnormalities were almost fully recovered within 2 weeks. Examination of the patient's and mother's erythrocyte enzyme activities revealed mildly decreased erythrocyte glutathione peroxidase (GSH-Px) activity. We speculate that patients with reduced GSH-Px activity are at a high risk of developing carbamazepine-induced hemolytic crisis and/or aplastic crisis.

PubMed

Quantification of adenovirus species B and C viremia by real-time PCR in adults and children undergoing stem cell transplantation.

Rumiko Takayama, Naoki Hatakeyama, Nobuhiro Suzuki, Masaki Yamamoto, Toshiaki Hayashi, Yukiho Ikeda, Hiroshi Ikeda, Hideki Nagano, Tadao Ishida, Hiroyuki Tsutsumi

Journal of medical virology   79 ( 3 ) 278 - 84  2007.03  [International journal]

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Adenovirus infection during stem cell transplantation is associated with high morbidity and mortality. Adenovirus species B and C have been the main causes for these infections; however, epidemiological details about the species are still unclear. To clarify the contributions of species B and C adenovirus, the DNA was tested serially by quantitative real-time PCR in peripheral blood, stool and urine of 32 patients (16 adults and 16 children) undergoing stem cell transplantation. Adenovirus species B viremia was detected in 10 of 16 adult and 6 of 16 pediatric transplant recipients. Adenovirus species C viremia was also detected simultaneously in five adult and three pediatric recipients. The stool and urine of patients with adenovirus viremia were also positive for the same adenovirus species as in blood. In contrast, in none of 50 healthy adult controls was adenovirus species B or C viremia detected. Among patients who developed adenovirus viremia, one adult recipient developed disseminated disease and died from multiple organ failure. The remaining patients experienced fever of several degrees and/or diarrhea during the period of adenovirus viremia; however, they all recovered without antiviral therapy. The results indicated that stem cell transplantation was frequently associated with adenovirus species B or C viremia, although it did not always cause serious infectious complications.

PubMed

Treatment of McLeod phenotype chronic granulomatous disease with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation.

Nobuhiro Suzuki, Naoki Hatakeyama, Masaki Yamamoto, Nobuo Mizue, Yuki Kuroiwa, Minami Yoda, Junko Takahashi, Yoshihiko Tani, Hiroyuki Tsutsumi

International journal of hematology   85 ( 1 ) 70 - 2  2007.01  [Domestic journal]

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Patients with chronic granulomatous disease (CGD) complicated by antimycotics-refractory invasive aspergillosis have an extremely poor prognosis if they cannot undergo allogeneic hematopoietic stem cell transplantation from a suitable related donor while in good clinical condition. We successfully treated a 20-year-old man with very rare McLeod phenotype CGD with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation. We postulate that reduced-intensity conditioning-allogeneic hematopoietic stem cell transplantation is a promising therapeutic strategy for patients with CGD even if only unrelated-donor umbilical cord blood is available.

PubMed

Treatment of stage IV malignant rhabdoid tumor of the kidney (MRTK) with ICE and VDCy: a case report.

Masaki Yamamoto, Nobuhiro Suzuki, Naoki Hatakeyama, Nobuo Mizue, Tsukasa Hori, Yuki Kuroiwa, Masato Hareyama, Takanori Oda, Tooru Kudoh, Akihiro Nui, Takashi Matsuno, Toshinori Hirama, Shigeaki Yokoyama, Jeffrey S Dome, Hiroyuki Tsutsumi

Journal of pediatric hematology/oncology   28 ( 5 ) 286 - 9  2006.05  [International journal]

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The prognosis of stage IV malignant rhabdoid tumor of the kidney (MRTK) has been extremely poor. However, a combination of ICE (ifosfamide, carboplatin, and etoposide) and VDCy (vincristine, doxorubicin, and cyclophosphamide) was recently reported to be effective for metastatic MRTK. We describe a 21-month-old girl with stage IV MRTK who was successfully treated with ICE, VDCy, and radiotherapy. She remained well, without recurrence, 24 months after diagnosis. Alternating therapy with ICE and VDCy might become a standard regimen for stage IV MRTK, although further study is required to confirm its effectiveness.

PubMed

Detection of BK virus and adenovirus in the urine from children after allogeneic stem cell transplantation.

Naoki Hatakeyama, Nobuhiro Suzuki, Masaki Yamamoto, Yuki Kuroiwa, Tsukasa Hori, Nobuo Mizue, Hiroyuki Tsutsumi

The Pediatric infectious disease journal   25 ( 1 ) 84 - 5  2006.01  [International journal]

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The development of hemorrhagic cystitis (HC) and urinary excretion of polyoma BK virus (BKV) and adenovirus (ADV) was investigated by polymerase chain reaction in 20 children undergoing allogeneic stem cell transplantation. Five children developed HC, and all of them excreted BKV; however, only 1 excreted ADV, suggesting that BKV is more significant cause of HC than ADV in children undergoing stem cell transplantation.

PubMed

Crohn's disease in a child with Down syndrome.

Masaki Yamamoto, Wataru Abo, Tsukasa Hori, Toshimasa Nakada, Naoki Tachibana, Yasumasa Hatada, Mitsuomi Kaimori

Pediatrics international : official journal of the Japan Pediatric Society   44 ( 5 ) 537 - 9  2002.10  [International journal]

PubMed