Education 【 display / non-display 】

Education 【 display / non-display 】

• 1994

  -

  2000

  Sapporo Medical University   医学部  

Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

• 2006

  　

  　

  日本臨床外科学会

• 2005

  -

  Now

  日本肺癌学会

• 2000

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  Now

  日本胸部外科学会

• 2000

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  Now

  日本呼吸器外科学会

• 2000

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  Now

  日本外科学会

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Respiratory surgery   robotic surgery

• Life sciences   Respiratory surgery   lung cancer, mediastinal tumor, metastatic tumor

• Life sciences   Immunology   organ transplant, synergy

Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University   Department of Thoracic Surgery   Assistant Professor  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• lung cancer

• Thoracic Surgery

• mediastinal tumor

• transplant immunology

Papers 【 display / non-display 】

Papers 【 display / non-display 】

• The Roles and Regulatory Mechanisms of Tight Junction Protein Cingulin and Transcription Factor Forkhead Box Protein O1 in Human Lung Adenocarcinoma A549 Cells and Normal Lung Epithelial Cells.

  Daichi Ishii, Yuma Shindo, Wataru Arai, Takumi Konno, Takayuki Kohno, Kazuya Honda, Masahiro Miyajima, Atsushi Watanabe, Takashi Kojima

  International journal of molecular sciences   25 ( 3 )  2024.01  [International journal]

  　View Summary

  Tight junction (TJ) protein cingulin (CGN) and transcription factor forkhead box protein O1 (FOXO1) contribute to the development of various cancers. Histone deacetylase (HDAC) inhibitors have a potential therapeutic role for some cancers. HDAC inhibitors affect the expression of both CGN and FOXO1. However, the roles and regulatory mechanisms of CGN and FOXO1 are unknown in non-small cell lung cancer (NSCLC) and normal human lung epithelial (HLE) cells. In the present study, to investigate the effects of CGN and FOXO1 on the malignancy of NSCLC, we used A549 cells as human lung adenocarcinoma and primary human lung epithelial (HLE) cells as normal lung tissues and performed the knockdown of CGN and FOXO1 by siRNAs. Furthermore, to investigate the detailed mechanisms in the antitumor effects of HDAC inhibitors for NSCLC via CGN and FOXO1, A549 cells and HLE cells were treated with the HDAC inhibitors trichostatin A (TSA) and Quisinostat (JNJ-2648158). In A549 cells, the knockdown of CGN increased bicellular TJ protein claudin-2 (CLDN-2) via mitogen-activated protein kinase/adenosine monophosphate-activated protein kinase (MAPK/AMPK) pathways and induced cell migration, while the knockdown of FOXO1 increased claudin-4 (CLDN-4), decreased CGN, and induced cell proliferation. The knockdown of CGN and FOXO1 induced cell metabolism in A549 cells. TSA and Quisinostat increased CGN and tricellular TJ protein angulin-1/lipolysis-stimulated lipoprotein receptor (LSR) in A549. In normal HLE cells, the knockdown of CGN and FOXO1 increased CLDN-4, while HDAC inhibitors increased CGN and CLDN-4. In conclusion, the knockdown of CGN via FOXO1 contributes to the malignancy of NSCLC. Both HDAC inhibitors, TSA and Quisinostat, may have potential for use in therapy for lung adenocarcinoma via changes in the expression of CGN and FOXO1.

  DOI PubMed

• Experimental and histological evaluation of each clamp technique for pulmonary artery.

  Yoshiki Chiba, Yuki Takahashi, Yoshiaki Takase, Kodai Tsuruta, Ryunosuke Maki, Masahiro Miyajima, Hirofumi Ohnishi, Atsushi Watanabe

  Interdisciplinary cardiovascular and thoracic surgery    2023.07  [Refereed]  [International journal]

  　View Summary

  OBJECTIVES: The double-loop technique has been used in our clinical settings for pulmonary arterioplasty and/or injured artery repair during thoracoscopic anatomical lung resection. We evaluated the pressure resistance capacity and intimal load to determine the effectiveness and safety of the double-loop technique. METHODS: The double-loop technique, DeBakey clamp, Fogarty clamp, endovascular clips, and vessel loop technique were evaluated. During an experimental study, a polyvinyl alcohol main pulmonary artery model, manometer, and in-deflation device were used to measure the burst pressure. The maximum clamp pressure was measured using a pressure-measuring film. Each measurement was performed 10 times. During the histological study, we measured the burst pressure and evaluated the intimal damage of the human pulmonary artery associated with the double-loop technique and DeBakey clamp. RESULTS: The experimental burst pressure (mmHg) and maximum clamp pressure (MPa) between the double-loop technique and DeBakey at the third notch were not significantly different (24.6 ± 2.8 and 21.8 ± 2.8, P = 0.094; 1.54 ± 0.12 and 1.49 ± 0.12, P = 0.954). During the histological study, the burst pressures of the double-loop technique and DeBakey at the third notch were also not significantly different (P = 0.754). Furthermore, the double-loop technique resulted in only intimal deformation in each five samples. CONCLUSIONS: The double-loop technique is feasible for thoracoscopic anatomical lung resection because it has similar pressure resistance capacity and intimal load as DeBakey at the third notch.

  DOI PubMed

• 特集 縦隔･胸壁腫瘍に対する低侵襲手術 1. ロボット支援下手術 手術支援ロボットを用いた縦隔腫瘍に対する低侵襲手術-ポート配置の工夫と適応の変遷

  槙 龍之輔, 鶴田 航大, 千葉 慶宜, 石井 大智, 大湯 岳, 佐藤 大軌, 宮島 正博, 渡辺 敦

  胸部外科 ( 南江堂 )  76 ( 7 ) 506 - 509  2023.07  [Refereed]

  DOI

• Recognition of subsuperior segmental vein for thoracoscopic subsuperior segmentectomy.

  Daichi Ishii, Yoshiaki Takase, Ryunosuke Maki, Yoshiki Chiba, Yuki Takahashi, Kodai Tsuruta, Masahiro Miyajima, Atsushi Watanabe

  JTCVS techniques   19   135 - 139  2023.06  [Refereed]  [International journal]

  DOI PubMed

• Metastatic pulmonary pleomorphic carcinoma replaced by a granulomatous lesion after spontaneous regression and PD-1 blockade-induced regression: can epithelioid granuloma be a histological hallmark of cancer immunity?

  Naoki Shijubou, Yuichiro Asai, Michiko Hosaka, Keiko Segawa, Terufumi Kubo, Masahiro Miyajima, Tomohide Tsukahara, Yoshihiko Hirohashi, Takayuki Kanaseki, Kenji Murata, Atsushi Watanabe, Tadashi Hasegawa, Hirofumi Chiba, Toshihiko Torigoe

  Immunological medicine   46 ( 2 ) 93 - 96  2023.06  [International journal]

  　View Summary

  Immune checkpoint inhibitors (ICIs) for various types of malignancy, including non-small-cell lung cancer, have improved prognosis in some cases. Granuloma formation after ICI administration suggests a tumor antigen-specific cytotoxic T cell response with abundant interferon-gamma production, which can be used to estimate the curative effect of ICIs. In this report, we present a case with a resected lung lesion, clinically suspected to be lung cancer, that consisted of a granulomatous lesion. A tumor was also found in the duodenum that was presumed to be derived from the pulmonary pleomorphic carcinoma. Duodenal tumor cells highly expressed PD-L1, suggesting PD-1/PD-L1 axis-mediated immune escape. As expected, pembrolizumab induced a complete response for the duodenal lesion. Interestingly, in histopathological analysis, the duodenal lesion was also replaced by an epithelial granuloma and multinucleated giant cells. We conclude that autoimmunity regressed the untreated primary lung lesion spontaneously, while the metastatic duodenal lesion responded to PD-1 blockade. Tumor-associated epithelioid granulomas, even before ICI administration, may be an important pathological finding indicating an immune response with interferon-gamma production by cytotoxic T cells to the tumor.

  DOI PubMed

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• クリーゼ中に胸腺摘除術を施行し良好な転帰が得られた胸腺腫合併抗AChR抗体陽性全身型重症筋無力症の一例

  河田 由香, 種本 真将, 山田 稔, 横川 和樹, 齋藤 太郎, 岩原 直敏, 松村 晃寛, 鈴木 秀一郎, 久原 真, 高瀬 貴章, 宮島 正博, 渡辺 敦

  臨床神経学 ( (一社)日本神経学会 )  63 ( 5 ) 325 - 325  2023.05

• 原発性肺癌浸潤CD4陽性T細胞組成と浸潤メカニズムの解析

  佐藤 太軌, 石井 大智, 大湯 岳, 千葉 慶宜, 鶴田 航大, 高橋 有毅, 槙 龍之輔, 高瀬 貴章, 宮島 正博, 渡辺 敦, 池上 一平, 一宮 慎吾

  肺癌 ( (NPO)日本肺癌学会 )  63 ( 2 ) 130 - 130  2023.04

• 大動脈浸潤を認めるT4肺癌に対してステントグラフト内挿術および肺葉切除を施行した1例

  大湯 岳, 槙 龍之輔, 石井 大智, 佐藤 太軌, 千葉 慶宜, 鶴田 航大, 高橋 有毅, 高瀬 貴章, 宮島 正博, 渡辺 敦

  肺癌 ( (NPO)日本肺癌学会 )  63 ( 2 ) 130 - 131  2023.04

• 呼吸器外科領域におけるトラブルシューティング ロボット支援下解剖学的肺切除術における術中トラブルシューティング

  高瀬 貴章, 千葉 慶宜, 高橋 有毅, 鶴田 航大, 槙 龍之輔, 宮島 正博, 渡辺 敦

  日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  27 ( 7 ) 1322 - 1322  2022.12

• ロボット支援下肺葉切除術中気道損傷に対してロボット支援下で修復を行った2例

  大湯 岳, 高橋 有毅, 千葉 慶宜, 槙 龍之輔, 鶴田 航大, 高瀬 貴章, 宮島 正博, 渡辺 敦

  日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  27 ( 7 ) 1465 - 1465  2022.12

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Teaching Experience 【 display / non-display 】

Teaching Experience 【 display / non-display 】

• 呼吸器病学  

  2021.04

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  Now