研究者詳細 - 宮島　正博

論文 - 宮島　正博

分割表示 98 件中 61 - 80 件目／全件表示 >>

Truncus Superior Artery Ventral to the Apical Vein of the Right Upper Lobe.

Ryunosuke Maki, Masahiro Miyajima, Taijiro Mishina, Atsushi Watanabe

The Annals of thoracic surgery 106 ( 1 ) e39 2018年07月 [国際誌]

[p40 Negative Basaloid Squamous Cell Carcinoma of the Lung;Report of a Case].

Ryunosuke Maki, Shintaro Sugita, Yusuke Ono, Masahiro Miyajima, Makoto Tada, Yuki Takahashi, Taijirou Mishina, Atsushi Watanabe

Kyobu geka. The Japanese journal of thoracic surgery 71 ( 7 ) 547 - 550 2018年07月 [国内誌]

Immunohistochemical staining is important for the differential diagnosis of basaloid squamous cell carcinoma(BSC)and other similar carcinomas, such as small-cell carcinomas and large-cell neuroendocrine carcinomas. p40 is a useful marker of squamous cell carcinoma that can be used for the diagnosis of BSC. We present the case of a 64-year-old man who was referred to our hospital for investigation of an abnormal shadow revealed on chest radiography. Computed tomography(CT) revealed a 16×11 mm nodule in the left lung(S1+2), and a thoracoscopic left upper lobectomy was performed. Histologically, lobular pattern with peripheral palisading was observed and the immunohistochemical staining revealed the tumor cells to be positive for p63 and negative for both p40 and neuroendocrine markers, leading to the diagnosis of BSC.

PubMed

特集呼吸器外科領域の救急外科治療—Emergency treatment for chest trauma

三品泰二郎, 宮島正博, 高橋有毅, 槙龍之輔, 多田周, 大川美穂, 新井航, 渡辺敦

北海道外科雑誌 = The Hokkaido journal of surgery / 北海道外科雑誌編集委員会編 ( 北海道外科学会 ) 63 ( 1 ) 2 - 5 2018年06月

CiNii

Reply to Suciu et al.

Taijiro Mishina, Atsushi Watanabe, Masahiro Miyajima

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 53 ( 4 ) 896 - 896 2018年04月 [国際誌]

DOI PubMed

What factors determine the survival of patients with an acute exacerbation of interstitial lung disease after lung cancer resection?

Masahiro Miyajima, Atsushi Watanabe, Toshihiko Sato, Satoshi Teramukai, Masahito Ebina, Kazuma Kishi, Yukihiko Sugiyama, Haruhiko Kondo, Satoru Kobayashi, Yutaka Takahashi, Hiroyuki Ito, Ryoji Yamamoto, Shigeki Sawada, Hideki Fujimori, Kazunori Okabe, Jun Arikura, Yasushi Shintani, Hiroshige Nakamura, Shinichi Toyooka, Tohru Hasumi, Takehiro Watanabe, Yoshinobu Hata, Hisashi Iwata, Minoru Aoki, Kazuhito Funai, Shuhei Inoue, Osamu Kawashima, Tomohiko Iida, Hiroshi Date

Surgery today 48 ( 4 ) 404 - 415 2018年04月 [国内誌]

PURPOSES: Acute exacerbation of interstitial pneumonia (AEIP) is a leading cause of death after lung cancer resection in patients with interstitial lung disease. METHODS: We retrospectively analyzed 1763 patients with non-small cell lung cancer with a clinical diagnosis of interstitial lung disease (ILD) who underwent lung cancer resection between 2000 and 2009 at 61 hospitals in Japan. AEIP occurred in 164 of 1763 (9.3%) patients with a mortality rate of 43.9% (72/164). Univariate and multivariate analyses were carried out to identify possible risk factors of fatal AEIP. We then analyzed the 164 patients who developed postoperative AEIP and identified the preoperative and postoperative risk factors. RESULTS: A multivariate regression analysis identified that the sex, percent vital capacity, neoadjuvant radiation, preoperative history of AEIP, preoperative use of steroids, usual interstitial pneumonia pattern on CT, and surgical procedures were independent preoperative risk factors for death due to AEIP. ILD patients with emphysema somehow showed a lower risk of fatal AEIP than those without emphysema in this study. CONCLUSIONS: This study revealed eight risk factors for fatal AEIP.

DOI PubMed

A new ENG mutation in a Japanese family with hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations.

Keiki Yokoo, Gen Yamada, Hirofumi Chiba, Aki Ishikawa, Hiroko Morisaki, Hiroshi Saijo, Sayaka Kudoh, Yasuo Kitamura, Naoki Hirokawa, Masahiro Miyajima, Atsushi Watanabe, Hiroki Takahashi

Respiratory medicine case reports 25 73 - 77 2018年 [国際誌]

We present a case series of four siblings with hereditary hemorrhagic telangiectasia (HHT) and pulmonary arteriovenous malformations (PAVM). The patients' mother has HHT. Case 1: A 22-year-old man developed dyspnea and epistaxis. CT revealed a large PAVM, treated by segmentectomy. Case 2: A 27-year-old woman developed epistaxis and dyspnea. CT revealed three PAVMs, treated by partial resection. Case 3: A 20-year-old woman developed dyspnea. CT revealed multiple PAVMs, treated with endovascular occlusion of the largest one. Case 4: A 12-year-old woman developed epistaxis. CT revealed multiple PAVMs, observed without treatment. Genetic testing identified a new mutation, ENG c.1517T>C (p.Leu506Pro), in all patients and their mother. We suspect that HHT in these patients may be associated with this ENG mutation.

DOI PubMed

Video-assisted thoracoscopic surgery node dissection for lung cancer treatment.

Atsushi Watanabe, Masahiro Miyajima, Taijiro Mishina, Kodai Tsuruta, Yuki Takahashi, Ryunosuke Maki, Makoto Tada

Surgery today 47 ( 12 ) 1419 - 1428 2017年12月 [国内誌]

PURPOSE: Mediastinal node dissection (MND) is an integral component of the surgical treatment for non-small cell lung cancer (NSCLC). Although video-assisted thoracoscopic surgery (VATS) has been used increasingly for lung cancer treatment, the accuracy of by VATS MND still remains controversial. We reviewed the surgical results of VATS MND for NSCLC. METHODS: A systematic review of literature was performed, and articles that fully described the surgical procedure, devices, and results of VATS MND were selected to compare the efficacy of MND by VATS and thoracotomy. RESULTS: Various techniques and equipments have been shown to perform adequate MND, but there is an argument as to the method of estimation of the accuracy of MND. Most of the recent studies showed that the nodal upstaging and number of dissected nodes are significantly lower by VATS than after thoracotomy. Oppositely, some studies showed VATS noninferiority in these issues. Complications such as chylothorax, pleural effusion, bleeding, and nerve damage were similar in both groups. CONCLUSIONS: Although ND by VATS remains controversial, VATS MND is becoming easier and more feasible owing to the development of more advanced endoscopic cameras and equipments. We should learn further to become more adept at performing adequate ND by VATS.

DOI PubMed

Elevated expression of JAM-A promotes neoplastic properties of lung adenocarcinoma.

Kazufumi Magara, Akira Takasawa, Makoto Osanai, Misaki Ota, Yohei Tagami, Yusuke Ono, Kumi Takasawa, Masaki Murata, Yoshihiko Hirohashi, Masahiro Miyajima, Gen Yamada, Tadashi Hasegawa, Norimasa Sawada

Cancer science 108 ( 11 ) 2306 - 2314 2017年11月 [国際誌]

A cell-cell adhesion protein, junctional adhesion molecule-A (JAM-A), has been shown to be involved in neoplasia of various organs. However, the fundamental role of JAM-A in tumorigenesis is still under debate because dysregulated expression of this protein has distinct effects, playing opposite roles in carcinogenesis depending on the target tissues. In the present study, we found elevated levels of JAM-A expression in lung adenocarcinoma and its preinvasive lesions, including atypical adenomatous hyperplasia and adenocarcinoma in situ by immunohistochemistry. We also showed that suppression of constitutive JAM-A expression conferred target cells with increased susceptibility to apoptosis in lung adenocarcinoma cells. Consequently, inhibition of JAM-A activity decreased colony-forming capability in vitro and tumorigenicity in vivo. The transformed phenotype following suppression of JAM-A expression was sufficient to reduce motile and invasive capacities. Importantly, knockout of JAM-A had striking effects on cells. Our observations suggest that increased expression of JAM-A promotes neoplasia of lung adenocarcinoma. In addition, an anti-JAM-A antibody efficiently reduced cell proliferation and provoked apoptosis, indicating the potential feasibility of JAM-A-inhibitory cancer therapy.

DOI PubMed

Relationship between onset of spontaneous pneumothorax and weather conditions.

Taijiro Mishina, Atsushi Watanabe, Masahiro Miyajima, Junji Nakazawa

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 52 ( 3 ) 529 - 533 2017年09月 [国際誌]

OBJECTIVES: Spontaneous pneumothorax (SP) results from the rupture of blebs or bullae. It has been suggested that changes in weather conditions may trigger the onset of SP. Our aim was to examine the association between the onset of primary SP with weather changes in the general population in Sapporo, Japan. METHODS: From January 2008 through September 2013, 345 consecutive cases with a diagnosis of primary SP were reviewed. All cases of primary SP developed in the area within 40 km from the Sapporo District Meteorological Observatory. Climatic measurements were obtained from the Observatory, which included 1-h readings of weather conditions. Logistic regression model was used to obtain predicted risks for the onset of SP with respect to weather conditions. RESULTS: SP occurred significantly when the atmospheric pressure decreased by - 18 hPa or less during 96 h before the survey date (odds ratio = 1.379, P = 0.026), when the pressure increased by 15 hPa or more during 72 h before the survey date (odds ratio = 1.095, P = 0.007) and when maximum fluctuation in atmospheric pressure over 22 hPa was observed during 96 h before the survey date (odds ratio = 1.519, P = 0.001). Other weather conditions, including the presence of thunderstorms, were not significantly correlated with the onset of pneumothorax. CONCLUSIONS: Changes in atmospheric pressure influence the onset of SP. Future studies on the relationship between the onset of SP and weather conditions on days other than before the onset and with large number of patients may enable us to predict the onset of SP in various regions and weather conditions.

DOI PubMed

[Management of Pulmonary Thromboembolism].

Taijiro Mishina, Masahiro Miyajima, Atsushi Watanabe

Kyobu geka. The Japanese journal of thoracic surgery 70 ( 8 ) 678 - 682 2017年07月 [国内誌]

Pulmonary thromboembolism is a fatal perioperative complication in general thoracic surgery. There is a report on its incidence of 2.68 cases out of 10,000 general thoracic surgeries. To prevent pulmonary thromboembolism, risk evaluation of an individual case and steady implementation of recommended preventive techiques are required. Because of the prevalence of guidelines for prevention, the incidence of pulmonary thromboembolism in the perioperative period is reducing. However, maximum prevention of deep vein thrombosis(DVT), which can lead to pulmonary thromboembolism, is impossible even if preventive measures are strictly implemented in the perioperative period. Mindful of potential DVT postoperatively, it is crucial to speculate perioperative acute pulmonary thromboembolism when sudden sensation of postoperative dyspnea occurs. For lifesaving measures, treatment along with diagnosis is necessary. In the presence of shock, pulmonary endarterectomy is recommended with percutaneous cardiopulmonary support, while in the absence of shock, treatment depends on a patient's condition.

PubMed

Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial-mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis.

Miki Yamaguchi, Sachie Hirai, Yusuke Tanaka, Toshiyuki Sumi, Masahiro Miyajima, Taijiro Mishina, Gen Yamada, Mitsuo Otsuka, Tadashi Hasegawa, Takashi Kojima, Toshiro Niki, Atsushi Watanabe, Hiroki Takahashi, Yuji Sakuma

Laboratory investigation; a journal of technical methods and pathology 97 ( 3 ) 232 - 242 2017年03月 [国際誌]

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease of unknown cause. IPF has a distinct histopathological pattern of usual interstitial pneumonia in which fibroblastic foci (FF) represent the leading edge of fibrotic destruction of the lung. Currently there are three major hypotheses for how FF are generated: (1) from resident fibroblasts, (2) from bone marrow-derived progenitors of fibroblasts, and (3) from alveolar epithelial cells that have undergone epithelial-mesenchymal transition (EMT). We found that FF dissociated capillary vessels from the alveolar epithelia, the basement membranes of which are fused in normal physiological conditions, and pushed the capillaries and elastic fibers down ~100 μm below the alveolar epithelia. Furthermore, the alveolar epithelial cells covering the FF exhibited a partial EMT phenotype. In addition, normal human alveolar epithelial cells in vitro underwent dynamic EMT in response to transforming growth factor-β signaling within 72 h. Because it seems that resident fibroblasts or bone marrow-derived cells cannot easily infiltrate and form FF between the alveolar epithelia and capillaries in tight contact with each other, FF are more likely to be derived from the epithelial-to-mesenchymal transitioned alveolar epithelia located over them. Moreover, histology and immunohistochemistry suggested that the FF formed in the lung parenchyma disrupt blood flow to the alveolar septa, thus destroying them. Consequently, collapse of the alveolar septa is likely to be the first step toward honeycombing in the lung during late stage IPF. On the basis of these findings, inhibition of transforming growth factor-β signaling, which can suppress EMT of the alveolar epithelial cells in vitro, is a potential strategy for treating IPF.

DOI PubMed

高齢者気管腺様嚢胞癌に対し気管管状切除・再建術を施行した1例

多田周, 高橋有毅, 槙龍之輔, 三品泰二郎, 宮島正博, 渡辺敦

肺癌 ( 特定非営利活動法人日本肺癌学会 ) 57 ( 7 ) 870 - 874 2017年

背景．高齢者に対する気管切除・再建術の報告はいまだ少ない．症例．84歳女性．検診で胸部異常陰影を指摘された．胸部CT検査で胸部中部気管前壁の結節性病変を認めた．前医で行われた経気管支鏡生検で腺様嚢胞癌の診断であった．胸骨正中切開で気管管状切除・再建術を施行した．術後合併症はなく，術後33日目に退院した．結論．80歳代女性患者の気管原発腺様嚢胞癌に対して気管切除・再建術を施行した．切除後12か月無再発生存中である．

DOI DOI2 CiNii

下行大動脈損傷予防のために肋骨骨折端を摘除した胸部外傷の１例

上村修二, 宮島正博, 窪田生美, 喜屋武玲子, 平山傑, 井上弘行, 渡辺敦, 成松英智

日本外傷学会雑誌 ( 一般社団法人日本外傷学会 ) 30 ( 1 ) 23 - 26 2016年

症例は19歳女性，交通事故で頭部，顔面挫創，両肺挫傷，両側気胸，両側多発肋骨骨折，肝損傷と腸骨開放骨折を受傷．来院後，気道緊急のため気管挿管施行し人工呼吸管理とした．CTで左第９肋骨骨折端と下行大動脈の距離が12mmと近接しており経過観察としていたが，受傷後５日には４mmと近接したため，胸腔鏡下に肋骨骨折端摘除術を施行した．左下後部肋骨骨折による遅発性の下行大動脈損傷は稀ではあるが発生すると致命的である．本症例は予防的に肋骨骨折端を摘除することにより下行大動脈損傷を予防することができた．

DOI CiNii

[Pulmonary Carcinoid Tumor with Cushing's Syndrome in a Patient who Underwent Pulmonary Resection by Video-Assisted Thoracic Surgery;Report of a Case].

Hiroshi Sato, Taijiro Mishina, Masahiro Miyajima, Atsushi Watanabe

Kyobu geka. The Japanese journal of thoracic surgery 68 ( 7 ) 543 - 5 2015年07月 [国内誌]

Pulmonary carcinoid tumor with Cushing's syndrome is comparatively rare disease. It is difficult to make an early diagnosis due to small size lesion in its early stage. We report a case of pulmonary carcinoid tumor with Cushing's syndrome successfully localised by positron emission tomography/computed tomography and was resected in the early stage. The levels of serum cortisol and adrenocorticotropic hormone( ACTH) decreased immediately after surgery, and the symptoms of Cushing's syndrome were relieved.

PubMed

低用量造影剤による肺癌術前3D-CT肺動静脈選択撮影法

小倉圭史, 渡辺敦, 宮島正博, 三品泰二郎, 吉川健太, 蝶野大樹, 三角昌吾, 田仲健朗, 虻川雅基

日本呼吸器外科学会雑誌 ( (一社)日本呼吸器外科学会 ) 29 ( 3 ) P38 - 1 2015年04月

転移性肺腫瘍—Metastatic lung tumors—特集肺に対する外科治療

宮島正博, 三品泰二郎, 渡辺敦

北海道外科雑誌 = The Hokkaido journal of surgery / 北海道外科雑誌編集委員会編 ( 北海道外科学会 ) 59 ( 1 ) 9 - 13 2014年06月

CiNii

救急領域における呼吸器外科—Emergency thoracic surgery—外科的な救急疾患

宮島正博, 三品泰二郎, 渡辺敦

北海道外科雑誌 = The Hokkaido journal of surgery / 北海道外科雑誌編集委員会編 ( 北海道外科学会 ) 59 ( 1 ) 19 - 23 2014年06月

CiNii

胸壁･横隔膜の手術-その1 胸壁再建法長径多穴性金属プレートによる曲面を維持した胸壁再建術後の遠隔期成績

田中明彦, 櫻庭幹, 松井俊尚, 三品泰二郎, 宮島正博, 小濱卓朗, 山内昭彦, 村木里誌, 大澤久慶

胸部外科 ( 南江堂 ) 67 ( 1 ) 54 - 59 2014年01月

DOI CiNii

[Evaluation of long-term results in patients who underwent reconstruction of thoracic wall with curved metal plates].

Akihiko Tanaka, Motoki Sakuraba, Toshihisa Matsui, Taijiro Mishina, Masahiro Miyajima, Takuro Obama, Akihiko Yamauchi, Satoshi Muraki, Hisayoshi Osawa

Kyobu geka. The Japanese journal of thoracic surgery 67 ( 1 ) 54 - 9 2014年01月 [国内誌]

Between 1992 and 2011, 22 patients underwent surgery of reconstruction of thoracic wall with curved metal plates for multiple rib fracture and resection of thoracic wall tumor. They were divided into 2 groups according to original disorders. Twelve cases of group A accepted surgical stabilization of traumatic multiple rib fractures with the metal plates fixed on the fractured ribs as an external brace. Ten patients of group B were suffered from thoracic wall tumors, including 1 fibrous dysplagia, 1 chondroma, 5 invasive lung cancer, 2 rib metastases and 1 primary chest wall cancer. After the resection of tumors, an average of 3.2 ribs were removed, the defects of full thickness chest wall were reconstructed using a combination of a polypropylene mesh and the metal plates. In both groups, there were no displacement of the plates and allergic reaction. Only 2 patients needed removal of the fixed plates due to pyothorax caused by pneumonia after crushing thoracic injuries. The long metal reconstruction plates with many perforations were very useful for reconstruction of chest wall because they were long enough to cover the whole length of widely resected chest defects and moderately soft enough to be appropriately bent or twist by hand at the time of operation. Moreover long-term result of the reconstructed chest wall was safe and satisfactory without severe complication.

PubMed

[Henoch-Schönlein Purpura with lung abscess].

Junji Nakazawa, Atsushi Watanabe, Tomohiro Nakajima, Taijiro Mishina, Masahiro Miyajima, Tetsuya Higami

Kyobu geka. The Japanese journal of thoracic surgery 66 ( 10 ) 886 - 9 2013年09月 [国内誌]

A 72-year-old man had underwent left lower lobectomy for squamous cell carcinoma in our hospital in 2008. Postoperative stage was I A (T1N0M0). In 2010, follow-up chest computed tomography (CT) images showed similar cavitary nodules in segments 2 and 8 of the right lung with positive uptake on fluorodeoxyglucose-positron emission tomography (FDG-PET) images. Physical examination, blood tests, and levels of serum tumor markers showed no abnormality. Transbronchial lung biopsy revealed the absence of malignant cells. Segment 8 of the right lower lobe with the nodule was partially resected, and pathological examination demonstrated lung abscess. He was discharged but was hospitalized in another hospital for purpuric rash, fever, and arthralgia. Microscopic albuminuria was noted, and renal biopsy revealed nephritis with immunoglobulin A( IgA)deposition. He was made a diagnosis of Henoch-Schönlein purpura. Oral steroid therapy( prednisolone 60 mg/d) was initiated, resulting in the improvement of symptoms and disapearance of the cavitary nodule in the right lung segment 2.

PubMed

　前のページ - 次のページ　

<宮島 正博>

論文 - 宮島 正博

<宮島　正博>

論文 - 宮島　正博