Details of a Researcher - SUGITA Shintarou

Papers - SUGITA Shintarou

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DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.

Taeko Matsuoka, Koji Kawai, Satoshi Ando, Shintaro Sugita, Shuya Kandori, Takahiro Kojima, Jun Miyazaki, Hiroyuki Nishiyama

Japanese journal of clinical oncology 46 ( 5 ) 475 - 81 2016.05 [International journal]

OBJECTIVE: DNA methyltransferase 3-like plays an important role in germ cell development. The aim of this study was to analyse the DNA methyltransferase 3-like protein expression in testicular germ cell tumors. METHODS: The immunohistochemical expression of DNA methyltransferase 3-like was examined in 86 testicular germ cell tumor specimens in various clinical settings. The association between DNA methyltransferase 3-like expression and disease stage was analyzed. RESULTS: DNA methyltransferase 3-like was strongly expressed in seven of the eight pure embryonal carcinomas (87.5%). Partial DNA methyltransferase 3-like expression was observed in 6 of 23 (26.1%) pure seminomas. Various degrees of DNA methyltransferase 3-like expression was observed in all four pure yolk sac tumors, of which three were prepubertal yolk sac tumors. In mixed germ cell tumors, DNA methyltransferase 3-like protein was expressed in various degrees in elements of the embryonal carcinoma (14/18, 77.8%), seminoma (4/11, 36.4%), teratoma (4/7, 57.1%) and choriocarcinoma (3/3, 100%) but not in the yolk sac tumors (0/4). When DNA methyltransferase 3-like expression was analyzed according to disease stages, it was significantly correlated with advanced seminoma rather than Stage I seminoma (46.2 vs. 0%, P = 0.019), whereas there was no significant difference in the DNA methyltransferase 3-like-positive proportion between Stage I and advanced disease in the mixed germ cell tumors. CONCLUSIONS: Our findings suggest that DNA methyltransferase 3-like protein may play roles not only in the development of embryonal carcinoma but also in the development of advanced pure seminoma and pure yolk sac tumor.

DOI PubMed

Diagnosis of desmoplastic small-round-cell tumor by cytogenetic analysis: a case report.

Senn Wakahashi, Tamotsu Sudo, Kotaro Ichida, Shintaro Sugita, Tadashi Hasegawa, Shoji Nagao, Satoshi Yamaguchi, Toshiko Sakuma, Hideto Yamada

Clinical case reports 4 ( 5 ) 520 - 3 2016.05 [International journal]

DOI PubMed

Diagnostic use of fluorescence in situ hybridization in expert review in a phase 2 study of trabectedin monotherapy in patients with advanced, translocation-related sarcoma.

Shintaro Sugita, Hiroko Asanuma, Tadashi Hasegawa

Diagnostic pathology 11 37 - 37 2016.04 [International journal]

Authorship： Lead author , Corresponding author

BACKGROUND: Fluorescence in situ hybridization (FISH) is one of the most powerful genetic analysis tools for pathological diagnoses. FISH can detect various genetic abnormalities including gene translocation that was specifically found in translocation-related sarcomas (TRSs). Here, we report the use of FISH in expert review in a phase 2 study of trabectedin monotherapy for patients with advanced TRS. METHODS: TRS patients (n = 76) were enrolled in the trial at 12 study sites after pathological diagnoses were made, including morphological examination with or without evidence of translocation by genetic testing. Following histological reviews of the representative specimens at the study sites, we performed immunohistochemistry using the appropriate antibodies and FISH for genetic confirmation of the tumor types in the expert review. RESULTS: Among the 76 TRS cases, no split signal for SS18 probe was detected by FISH in three synovial sarcoma cases that were diagnosed at the study sites. Malignant peripheral nerve sheath tumor (MPNST) was diagnosed in two cases and sarcomatoid carcinoma in one. One of the cases was a small round cell variant of MPNST. After excluding these three cases, we assessed the other 73. There were no split signals detected in 7 of the 73 cases by FISH analysis, due to decalcification and hyperfixation procedures. Excluding these seven cases, FISH detected translocations in 95 % (63/66) of the study cases with a high sensitivity. CONCLUSIONS: The diagnosis of TRS by FISH was highly sensitive and enabled genetic confirmation of the pathological diagnoses. We strongly recommend FISH as a confirmatory diagnostic test for TRS, which would enable the selection of patients with TRS in whom trabectedin is expected to be effective. This study was done in part that registered with Japan Pharmaceutical Information Center, number JapicCTI-121850.

DOI PubMed

Primary pulmonary Ewing sarcoma.

Hiroshi Hirano, Hajime Maeda, Yukiyasu Takeuchi, Naoko Ose, Hiromi Fujita, Shintaro Sugita, Tadashi Hasegawa

Pathology international 66 ( 4 ) 239 - 41 2016.04 [International journal]

DOI PubMed

Angiomyxomatous tumor of the falx cerebri.

Shintaro Sugita, Masahiko Obata, Seiji Takebayashi, Tomoki Kikuchi, Tadashi Hasegawa

Pathology international 66 ( 1 ) 50 - 1 2016.01 [International journal]

Authorship： Lead author

DOI PubMed

Surgical and oncological impact of main pancreatic duct spread in invasive ductal adenocarcinoma: A clinicopathological study of 184 resected cases

Masayuki Ishii, Yasutoshi Kimura, Shintaro Sugita, Masafumi Imamura, Tatsuya Ito, Takayuki Nobuoka, Makoto Meguro, Tadashi Hasegawa, Toru Mizuguchi, Koichi Hirata

Pancreatology ( Elsevier BV ) 15 ( 6 ) 681 - 687 2015.11 [Refereed]

DOI

IgG4-related disease initially presented as an orbital mass lesion mimicking optic nerve sheath meningioma.

Shouhei Noshiro, Masahiko Wanibuchi, Yukinori Akiyama, Satoshi Okawa, Shunya Ohtaki, Toshiya Sugino, Satoshi Iihoshi, Takeshi Mikami, Shintaro Sugita, Tadashi Hasegawa, Nobuhiro Mikuni

Brain tumor pathology 32 ( 4 ) 286 - 90 2015.10 [Domestic journal]

We report a case of an optic nerve mass lesion associated with IgG4-related disease. A 39-year-old man presented with right blurred vision and proptosis 8 years before admission. Magnetic resonance imaging showed a mass lesion in the center of the right orbit, which was diagnosed as optic nerve sheath meningioma by neuroradiologists and neurosurgeons. Irradiation was selected for treatment of the lesion on the basis of the radiological diagnosis; subsequently, the lesion gradually reduced in size. However, regrowth of an optic nerve mass lesion observed during the previous 2 years caused remarkable exophthalmos, and removal of the orbital mass lesion was performed via a transcranial orbital approach. Pathological examinations resulted in a diagnosis of IgG4-related disease, and hematological tests revealed an elevated level of serum IgG4. Additional radiological examinations showed mass lesions in the left maxillary nerve, bilateral inferior alveolar nerves, paravertebral tissue, and left kidney. Treatment with oral steroids has produced a reduction in the size of these lesions.

DOI PubMed

Nasopharyngeal hyalinizing clear cell carcinoma with EWSR1 rearrangements diagnosed by fluorescence in situ hybridization.

Atsushi Fukuda, Yohei Tagami, Akira Takasawa, Shintaro Sugita, Rinnosuke Kuramoto, Suguru Imai, Tadashi Hasegawa, Keiji Iizuka

Auris, nasus, larynx 42 ( 5 ) 412 - 5 2015.10 [International journal]

Hyalinizing clear cell carcinoma (HCCC) is a rare, low-grade salivary gland neoplasm with a predilection for the palate and tongue. A 63-year-old woman presented a 14×14×17-mm mass at the roof of the nasopharynx. Endoscopic resection was performed via a transnasal approach. Histopathological findings of the salivary gland tumor indicated hyalinization of the stroma and neoplastic cells with clear cytoplasm without mucin. Fluorescence in situ hybridization analysis revealed that the tumor cells were positive for EWSR1 rearrangement. We finally diagnosed this case as HCCC of the nasopharynx. EWSR1 rearrangements are non-existent in other salivary gland tumors with clear cell change; thus, the identification of this rearrangement was very useful in accurately diagnosing HCCC.

DOI PubMed

Experience using denosumab for lung metastases of giant cell tumor of bone

Yuto Watanabe, Mitsunori Kaya, Mikito Sasaki, Masato Emori, Yasutaka Murahashi, Emi Mizushima, Tamotsu Souma, Shintaro Sugita, Tadashi Hasegawa, Toshihiko Yamashita

European Orthopaedics and Traumatology ( Springer Verlag ) 6 ( 3 ) 239 - 241 2015.09

The treatment of unresectable multiple lung metastasis of giant cell tumor of bone (GCTB) is challenging. In the current manuscript, we present a case who presented with multiple lung metastases of GCTB and was successfully managed with the use of denosumab allowing for surgical resection of the metastatic lesions that was previously deemed unresectable. Pathologic examination also clearly demonstrated the histological effects of denosumab. We emphasize on effective response to denosumab even in metastatic GCTB.

DOI

Prognostic impact of CD109 expression in myxofibrosarcoma.

Makoto Emori, Tomohide Tsukahara, Kenji Murata, Shintaro Sugita, Tomoko Sonoda, Mitsunori Kaya, Tamotsu Soma, Mikito Sasaki, Satoshi Nagoya, Tadashi Hasegawa, Takuro Wada, Noriyuki Sato, Toshihiko Yamashita

Journal of surgical oncology 111 ( 8 ) 975 - 9 2015.06 [International journal]

BACKGROUND: CD109, a TGF-β co-receptor, is reported to be preferentially expressed during the early stages of tumorigenesis in several carcinoma types. Myxofibrosarcoma is one of the most common soft-tissue sarcomas found in elderly patients. This study aimed to elucidate the impact of CD109 expression in myxofibrosarcoma on prognosis and recurrence. METHODS: Immunohistochemical staining for CD109 was performed on archival specimens from 37 patients. The Fisher exact test was used to evaluate association between CD109 expression and other clinicopathological features. Survival analysis was performed using Kaplan-Meier curves, and the prognostic significance was evaluated using the log-rank test. Multivariate analysis of factors was performed using Cox regression analysis. RESULTS: CD109 overexpression was significantly associated with surgical stage and distant metastasis (P = 0.00499, and 0.011, respectively). The frequency of CD109 overexpression was approximately 10% and CD109 overexpression was significantly associated with decreased overall survival (P = 0.004). Five-year overall survival rates 77% and 0% for CD109-negative and CD109-positive patients, respectively. In multivariate analysis, CD109 overexpression was the only independent risk factor for poor outcome (P = 0.02; hazard ratio, 10.64; 95% confidence interval, 1.47-76.91). CONCLUSIONS: Immunohistochemical CD109 expression in myxofibrosarcoma was associated with poor prognosis.

DOI PubMed

Recurrent pulmonary synovial sarcoma effectively treated with amrubicin: A case report.

Hiroaki Satoh, Norio Takayashiki, Toshihiro Shiozawa, Kunihiko Miyazaki, Gen Ohara, Katsunori Kagohashi, Koichi Kurishima, Shintaro Sugita, Tomoyuki Aoyama, Tadashi Hasegawa, Nobuyuki Hizawa

Experimental and therapeutic medicine 9 ( 5 ) 1947 - 1949 2015.05 [International journal]

Pulmonary synovial sarcoma is a rare but aggressive disease. The present study describes the case of a 68-year-old female with pulmonary synovial sarcoma. The patient was mistakenly treated for small cell lung cancer due to false-positive staining for synaptophysin and cluster of differentiation 56. Despite severe myelotoxicity, platinum-containing chemotherapies (cisplatin plus irinotecan and carboplatin plus etoposide) were not effective. As a third-line therapy, the patient received amrubicin (AMR) monotherapy. A partial response was achieved, and the patient was able to undertake ordinary daily life at home for 13 months from the initiation of AMR chemotherapy. Due to the atypical clinical condition and unusual response to chemotherapy in this patient, the pathological examination was repeated. The SS18 split-signal was detected in fluorescence in situ hybridization analysis. From these results, the tumor was diagnosed as a monophasic synovial sarcoma. To the best of our knowledge, this is the first case of a patient with pulmonary synovial sarcoma who underwent successful treatment with AMR. The present case could demonstrate a specific chemosensitivity of such a rare tumor.

PubMed

A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.

Shintaro Sugita, Yasuhito Arai, Akiko Tonooka, Natsuko Hama, Yasushi Totoki, Tomoki Fujii, Tomoyuki Aoyama, Hiroko Asanuma, Tomohide Tsukahara, Mitsunori Kaya, Tatsuhiro Shibata, Tadashi Hasegawa

The American journal of surgical pathology 38 ( 11 ) 1571 - 6 2014.11 [International journal]

Authorship： Lead author

Differential diagnosis of small round cell sarcomas (SRCSs) grouped under the Ewing sarcoma family of tumors (ESFT) can be a challenging situation for pathologists. Recent studies have revealed that some groups of Ewing-like sarcoma show typical ESFT morphology but lack any EWSR1-ETS gene fusions. Here we identified a novel gene fusion, CIC-FOXO4, in a case of Ewing-like sarcoma with a t(X;19)(q13;q13.3) translocation. The patient was a 63-year-old man who had an asymptomatic, 30-mm, well-demarcated, intramuscular mass in his right posterior neck, and imaging findings suggested a diagnosis of high-grade sarcoma. He was treated with complete resection and subsequent radiotherapy and chemotherapy. He was alive without local recurrence or distant metastasis 6 months after the operation. Histologic examination revealed SRCS with abundant desmoplastic fibrous stroma suggesting a desmoplastic small round cell tumor. Immunohistochemical analysis showed weak to moderate and partial staining for MIC2 (CD99) and WT1, respectively. High-throughput transcriptome sequencing revealed a gene fusion, and the genomic rearrangement between the CIC and FOXO4 genes was identified by fluorescence in situ hybridization. Aside from the desmoplastic stroma, the CIC-FOXO4 fusion sarcoma showed morphologic and immunohistochemical similarity to ESFT and Ewing-like sarcomas, including the recently described CIC-DUX4 fusion sarcoma. Although clinicopathologic analysis with additional cases is necessary, we conclude that CIC-FOXO4 fusion sarcoma is a new type of Ewing-like sarcoma that has a specific genetic signature. These findings have important implications for the differential diagnosis of SRCS.

DOI PubMed

Expression of the oncoprotein gankyrin and phosphorylated retinoblastoma protein in human testis and testicular germ cell tumor.

Satoshi Ando, Taeko Matsuoka, Koji Kawai, Shintaro Sugita, Akira Joraku, Takahiro Kojima, Takahiro Suetomi, Jun Miyazaki, Jun Fujita, Hiroyuki Nishiyama

International journal of urology : official journal of the Japanese Urological Association 21 ( 10 ) 992 - 8 2014.10 [International journal]

OBJECTIVE: The oncoprotein, gankyrin, is known to facilitate cell proliferation through phosphorylation and degradation of retinoblastoma protein. In the present study, we evaluated the expression of gankyrin and phosphorylated retinoblastoma protein in human testis and testicular germ cell tumors. METHODS: The effects of suppression of gankyrin by locked nucleic acid on phosphorylation status of retinoblastoma and cell proliferation were analyzed using western blot analysis and testicular tumor cell line NEC8. The expressions of gankyrin, retinoblastoma and retinoblastoma protein were analyzed in 93 testicular germ cell tumor samples and five normal human testis by immunohistochemistry. The retinoblastoma protein expression was determined using an antibody to retinoblastoma protein, Ser795. RESULTS: Gankyrin was expressed in NEC8 cells as well as a normal human testis and testicular tumors. Suppression of gankyrin by locked nucleic acid led to suppression of retinoblastoma protein and cell proliferation in NEC8 cells. Immunohistochemistry of normal testis showed that gankyrin is expressed dominantly in spermatocytes. In testicular germ cell tumors, high expressions of gankyrin and phosphorylated-retinoblastoma protein were observed in seminoma and embryonal carcinoma, whereas the expressions of both proteins were weak in histological subtypes of non-seminoma. Growing teratoma and testicular malignant transformation tissues expressed phosphorylated-retinoblastoma protein strongly, but gankyrin faintly. CONCLUSION: Gankyrin is dominantly expressed in normal spermatocytes and seminoma/embryonal carcinoma, and its expression correlates well with retinoblastoma protein expression except in the growing teratoma and testicular malignant transformation cases. These data provide new insights into the molecular mechanisms of normal spermatogenesis and pathogenesis of testicular germ cell tumors.

DOI PubMed

Diagnostic utility of NCOA2 fluorescence in situ hybridization and Stat6 immunohistochemistry staining for soft tissue angiofibroma and morphologically similar fibrovascular tumors.

Shintaro Sugita, Tomoyuki Aoyama, Kei Kondo, Yoshiko Keira, Jiro Ogino, Katsuya Nakanishi, Mitsunori Kaya, Makoto Emori, Tomohide Tsukahara, Hisaya Nakajima, Masayuki Takagi, Tadashi Hasegawa

Human pathology 45 ( 8 ) 1588 - 96 2014.08 [International journal]

Authorship： Lead author

Soft tissue angiofibroma (STA), a recently suggested new histologic entity, is a benign fibrovascular soft tissue tumor composed of bland spindle-shaped tumor cells with abundant collagenous to myxoid stroma and branching small vessels. The lesion has a characteristic AHRR-NCOA2 fusion gene derived from chromosomal translocation of t(5;8)(p15;q13). However, morphologically similar tumors containing abundant fibrovascular and myxoid stroma can complicate diagnosis. We designed an original DNA probe for detecting NCOA2 split signals on fluorescence in situ hybridization (FISH) and estimated its utility with 20 fibrovascular tumors: 4 each of STAs, solitary fibrous tumors (SFTs), and cellular angiofibromas and 3 each of low-grade myxofibrosarcomas, myxoid liposarcomas, and low-grade fibromyxoid sarcomas. We also performed FISH for 13q14 deletion and immunohistochemistry (IHC) staining for estrogen receptor, progesterone receptor, retinoblastoma protein, and MUC-4 expression. Furthermore, IHC for Stat6 was conducted in the 20 cases analyzed by FISH and in an additional 26 SFTs. We found moderate to strong nuclear Stat6 expression in all SFTs but no expression in the other tumors. Both estrogen receptor and progesterone receptor expressions were observed in STAs, SFTs, and cellular angiofibromas. Expression of retinoblastoma protein was found in less than 10% of cells in all tumor types except myxoid liposarcoma. The low-grade fibromyxoid sarcomas were strongly positive for MUC-4. All STAs showed NCOA2 split signals on FISH. All tumors, regardless of histologic type, had 13q14 deletion. The NCOA2 FISH technique is a practical method for confirming STA diagnosis. The combination of NCOA2 FISH and Stat6 IHC proved effective for the differential diagnosis of STA, even when using small biopsy specimens.

DOI PubMed

Analysis of gene expression profiles of soft tissue sarcoma using a combination of knowledge-based filtering with integration of multiple statistics.

Anna Takahashi, Robert Nakayama, Nanako Ishibashi, Ayano Doi, Risa Ichinohe, Yoriko Ikuyo, Teruyoshi Takahashi, Shigetaka Marui, Koji Yasuhara, Tetsuro Nakamura, Shintaro Sugita, Hiromi Sakamoto, Teruhiko Yoshida, Tadashi Hasegawa, Hiro Takahashi

PloS one 9 ( 9 ) e106801 2014 [International journal]

The diagnosis and treatment of soft tissue sarcomas (STS) have been difficult. Of the diverse histological subtypes, undifferentiated pleomorphic sarcoma (UPS) is particularly difficult to diagnose accurately, and its classification per se is still controversial. Recent advances in genomic technologies provide an excellent way to address such problems. However, it is often difficult, if not impossible, to identify definitive disease-associated genes using genome-wide analysis alone, primarily because of multiple testing problems. In the present study, we analyzed microarray data from 88 STS patients using a combination method that used knowledge-based filtering and a simulation based on the integration of multiple statistics to reduce multiple testing problems. We identified 25 genes, including hypoxia-related genes (e.g., MIF, SCD1, P4HA1, ENO1, and STAT1) and cell cycle- and DNA repair-related genes (e.g., TACC3, PRDX1, PRKDC, and H2AFY). These genes showed significant differential expression among histological subtypes, including UPS, and showed associations with overall survival. STAT1 showed a strong association with overall survival in UPS patients (logrank p = 1.84 × 10(-6) and adjusted p value 2.99 × 10(-3) after the permutation test). According to the literature, the 25 genes selected are useful not only as markers of differential diagnosis but also as prognostic/predictive markers and/or therapeutic targets for STS. Our combination method can identify genes that are potential prognostic/predictive factors and/or therapeutic targets in STS and possibly in other cancers. These disease-associated genes deserve further preclinical and clinical validation.

DOI PubMed

[Case of metastatic malignant melanoma of the urinary bladder].

Atsushi Ikeda, Tomoaki Miyagawa, Masahiro Kurobe, Masahiro Uchida, Takahiro Kojima, Masakazu Tsutsumi, Shusaku Ito, Shintaro Sugita, Hiroyuki Nishiyama

Hinyokika kiyo. Acta urologica Japonica 59 ( 9 ) 579 - 82 2013.09 [Domestic journal]

A 54-year-old woman underwent resection of malignant melanoma of the left leg and inguinal lymph node metastases and subsequent radiation therapy (60 Gy) following three courses of dacarbazine, nimustine, vincristine and interferon-beta chemotherapy in January 2010. In September 2011, she was referred to our department with the chief complaint of asymptomatic gross hematuria. A non-papillary bladder tumor was detected on cystoscopy and fluorodeoxyglucose (FDG) positron emission fomography-computed tomography revealed increased uptake of FDG only in the area of the bladder tumor. Melanoma cells were also found on urinary cytology. Our diagnosis was metastatic malignant melanoma of the bladder. Complete transurethral resection of the bladder tumor was performed, and pathological examination confirmed metastatic malignant melanoma. Metastatic bladder tumors constitute less than 5% of all bladder tumors. There are metastases in other organs at the time of diagnosis in almost all cases. In Japan, metastatic malignant melanoma of the urinary bladder is rare in clinical practice, there having been about a dozen reported cases. Solitary metastasis as in our case is even rarer.

PubMed

Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses.

Hiro Takahashi, Robert Nakayama, Shuhei Hayashi, Takeshi Nemoto, Yasuyuki Murase, Koji Nomura, Teruyoshi Takahashi, Kenji Kubo, Shigetaka Marui, Koji Yasuhara, Tetsuro Nakamura, Takuya Sueo, Anna Takahashi, Kaname Tsutsumiuchi, Tsutomu Ohta, Akira Kawai, Shintaro Sugita, Shinjiro Yamamoto, Takeshi Kobayashi, Hiroyuki Honda, Teruhiko Yoshida, Tadashi Hasegawa

PloS one 8 ( 10 ) e78250 2013 [International journal]

The diagnosis and treatment of soft tissue sarcomas (STSs) has been particularly difficult, because STSs are a group of highly heterogeneous tumors in terms of histopathology, histological grade, and primary site. Recent advances in genome technologies have provided an excellent opportunity to determine the complete biological characteristics of neoplastic tissues, resulting in improved diagnosis, treatment selection, and investigation of therapeutic targets. We had previously developed a novel bioinformatics method for marker gene selection and applied this method to gene expression data from STS patients. This previous analysis revealed that the extracted gene combination of macrophage migration inhibitory factor (MIF) and stearoyl-CoA desaturase 1 (SCD1) is an effective diagnostic marker to discriminate between subtypes of STSs with highly different outcomes. In the present study, we hypothesize that the combination of MIF and SCD1 is also a prognostic marker for the overall outcome of STSs. To prove this hypothesis, we first analyzed microarray data from 88 STS patients and their outcomes. Our results show that the survival rates for MIF- and SCD1-positive groups were lower than those for negative groups, and the p values of the log-rank test are 0.0146 and 0.00606, respectively. In addition, survival rates are more significantly different (p = 0.000116) between groups that are double-positive and double-negative for MIF and SCD1. Furthermore, in vitro cell growth inhibition experiments by MIF and SCD1 inhibitors support the hypothesis. These results suggest that the gene set is useful as a prognostic marker associated with tumor progression.

DOI PubMed

[Mixed type ureteral endometriosis : a case report and a review of the Japanese literature].

Masahiro Kurobe, Takahiro Kojima, Masahiro Uchida, Tomoaki Miyagawa, Masakazu Tsutsumi, Shintaro Sugita

Hinyokika kiyo. Acta urologica Japonica 58 ( 7 ) 329 - 33 2012.07 [Domestic journal]

Ureteral endometriosis is a rare but important clinical problem that requires early detection and treatment. The urinary tract is affected in approximately 2% of women with endometriosis. Even though the bladder is the most frequent urinary tract organ affected in these patients,the ureter is also affected in 10-40% of the cases, thus requiring immediate clinical attention. The majority of endometrial lesions is typically located in the lower segment of the ureter and is often difficult to differentiate between endometriosis and malignancy. Ureteral endmetriosis should be considered for women with hydronephrosis. In this report we present one clinical case of mixed-type ureteral endometriosis. A 37-year-old woman was referred to our hospital due to left hydronephrosis. Contrast-enhanced CT scan confirmed left hydronephrosis and also showed a solid mass at the left lower ureter. Retrograde pyelography revealed stenosis of the left lower ureter and Renogram revealed severely impaired renal function. Laparoscopic nephroureterectomy was performed. Pathologically, mixed-type endometriosis of the left ureter was diagnosed.

PubMed

[Spindle cell sarcoma of the penis: a case report].

Tomokazu Kimura, Takehiro Oikawa, Atsushi Ikeda, Takayuki Yoshino, Takahiro Suetomi, Jun Miyazaki, Toru Shimazui, Takayuki Hashimoto, Shintaro Sugita, Masayuki Noguchi, Hiroyuki Nishiyama

Hinyokika kiyo. Acta urologica Japonica 58 ( 6 ) 299 - 305 2012.06 [Domestic journal]

A 75-year-old man, with a past history of radiation therapy for prostatic carcinoma ten years ago, was referred to our hospital with complaints of penile tumor. After pathological examination by core biopsy, the patient was treated by radical penectomy for a penile tumor. Pathological examinations demonstrated that the tumor was composed of pleomorphic spindle cells without any differentiation tendency and diagnosed as spindle cell sarcoma. Although the patient had a past history of radiation therapy for the prostate, the causal relation of development of penile sarcoma with the radiation therapy was uncertain because the main tumor was very near but outside of the irradiation field. The sarcoma rarely occurs in the penis, and this is the first report of penile spindle cell sarcoma, to our knowledge.

PubMed

Extra-abdominal desmoid tumor in the subcutis of the thigh.

Yasuhiro Fujisawa, Shintaro Sugita, Yasuhiro Kawachi, Fujio Otsuka

The Journal of dermatology 38 ( 8 ) 810 - 2 2011.08 [International journal]

DOI PubMed

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Papers - SUGITA Shintarou