Details of a Researcher - SHIMA Hiroaki

乳癌原発巣と転移を伴うリンパ節,転移を伴わないリンパ節におけるT-cellの分化と分布

島宏彰, 九冨五郎, 空閑陽子, 和田朝香, 里見蕗乃, 廣橋良彦, 鳥越俊彦, 竹政伊知朗

日本乳癌学会学術総会プログラム・抄録集 30th (CD-ROM) 2022

乳癌原発巣と転移巣における腫瘍免疫微小環境の病理学的比較検討

和田朝香, 九冨五郎, 島宏彰, 空閑陽子, 竹政伊知朗, 和田朝香, 廣橋良彦, 鳥越俊彦

北海道外科雑誌 67 ( 2 ) 2022

hERO1-Lαを標的としたトリプルネガティブ乳癌の新規治療戦略

和田朝香, 和田朝香, 廣橋良彦, 田村保明, 九冨五郎, 島宏彰, 空閑陽子, 竹政伊知朗, 鳥越俊彦

日本臨床ストレス応答学会大会抄録集 16th 2022

hERO1-Lαを標的としたトリプルネガティブ乳癌の新規治療戦略

和田朝香, 和田朝香, 九冨五郎, 廣橋良彦, 島宏彰, 空閑陽子, 里見蕗乃, 鳥越俊彦, 竹政伊知朗

日本乳癌学会学術総会プログラム・抄録集 30th (CD-ROM) 2022

Immunohistological analysis of the unresectable pancreatic carcinoma after survivin 2B peptide vaccination

Terufumi Kubo, Giichiro Tsurita, Yoshihiko Hirohashi, Yasunori Ota, Hiroshi Yasui, Kazue Watanabe, Aiko Murai, Hiroko Asanuma, Hiroaki Shima, Ichiro Takemasa, Toru Mizuguchi, Noriyuki Sato, Toshihiko Torigoe

CANCER SCIENCE ( WILEY ) 109 1335 - 1335 2018.12

Research paper, summary (international conference)

進行膵がんに対するがん免疫療法

鳥越俊彦, 島宏彰, 水口徹, 木村康利, 竹政伊知朗, 釣田義一郎, 安井寛, 和田聡

膵臓 ( 日本膵臓学会 ) 33 ( 3 ) 324 - 324 2018.05

膵癌における免疫療法-基礎と臨床- 進行膵がんに対するがん免疫療法

鳥越俊彦, 島宏彰, 水口徹, 木村康利, 竹政伊知朗, 釣田義一郎, 安井寛, 和田聡

膵臓 ( 日本膵臓学会 ) 33 ( 3 ) 324 - 324 2018.05

サバイビン2Bペプチドワクチン第II相試験施行後の膵癌組織の免疫病理学的解析

久保輝文, 釣田義一郎, 廣橋良彦, 大田泰徳, 安井寛, 渡邉一絵, 村井愛子, 浅沼広子, 島宏彰, 塚原智英, 金関貴幸, 中津川宗秀, 水口徹, 竹政伊知朗, 平田公一, 佐藤昇志, 鳥越俊彦

日本臨床免疫学会総会プログラム・抄録集 46th 2018

サバイビン2Bペプチドワクチン第II相試験施行後の膵癌組織の免疫病理学的解析

日本臨床免疫学会総会プログラム・抄録集 46th 2018

外科医のための癌免疫療法進行膵臓がんを対象とした複合型CTLワクチン療法第2相試験

水口徹, 島宏彰, 九冨五郎, 木村康利, 竹政伊知朗, 鳥越俊彦, 廣橋良彦, 塚原智英, 金関貴幸, 釣田義一郎, 安井寛, 和田聡, 林宏至, 宮腰崇

日本臨床外科学会雑誌 ( 日本臨床外科学会 ) 78 ( 増刊 ) 419 - 419 2017.10

臨牀指針両側共に特殊型の同時性両側乳癌の1例

前田豪樹, 九冨五郎, 里見蕗乃, 島宏彰, 宇野智子, 長谷川匡, 竹政伊知朗

臨牀と研究 = The Japanese journal of clinical and experimental medicine ( 大道学館出版部 ) 94 ( 5 ) 604 - 607 2017.05

Current status of the prognostic molecular biomarkers in breast cancer: A systematic review

Goro Kutomi, Toru Mizuguchi, Fukino Satomi, Hideki Maeda, Hiroaki Shima, Yasutoshi Kimura, Koichi Hirata

ONCOLOGY LETTERS ( SPANDIDOS PUBL LTD ) 13 ( 3 ) 1491 - 1498 2017.03

Book review, literature introduction, etc.

Biomarkers that facilitate the prediction of breast cancer prognosis can improve the quality of life in patients during the long period of illness and treatment. Particularly in recent years, with the advent of a more exhaustive analysis of genetic information and gene products, the molecular mechanisms at play during breast cancer have gradually become clearer. In the present study, a systematic review of the literature between 2009 and 2014 was conducted by searching for the keywords 'breast cancer', 'biomarkers', 'diagnosis', 'prognosis' and 'drug response' to clarify the present state of knowledge regarding biomarkers. In the final analysis, 16 studies on biomarkers for the breast cancer prognosis were retrieved. From these, 7 biomarkers in 9 studies were found to be strongly reliable predictors of prognosis and a further 7 biomarkers in 7 studies were poorly reliable. The use of these prognostic biomarkers should increase the options available for treatment algorithms.

Association between CYP2D6 genotype and response to tamoxifen in a prospective multicenter study in Japan

Hitoshi Zembutsu, Seigo Nakamura, Sadako Akashi-Tanaka, Takashi Kuwayama, Chie Watanabe, Tomoko Takamaru, Hiroyuki Takei, Kana Miyahara, Hiroshi Matsumoto, Yoshie Hasegawa, Goro Kutomi, Hiroaki Shima, Fukino Satomi, Hideki Maeda, Minoru Okazaki, Hisamitsu Zaha, Mai Onomura, Ayami Matsukata, Yasuaki Sagara, Shinichi Baba, Akimitsu Yamada, Kazuhiro Shimada, Daisuke Shimizu, Koichiro Tsugawa, Arata Shimo, Tan Ern Yu, Mikael Hartman, Chan Ching Wang, Soo Chin Lee, Yusuke Nakamura

CANCER RESEARCH ( AMER ASSOC CANCER RESEARCH ) 76 2016.07

Research paper, summary (international conference)

Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?

Toru Mizuguchi, Toshihiko Torigoe, Fukino Satomi, Hiroaki Shima, Goro Kutomi, Shigenori Ota, Masayuki Ishii, Hiroshi Hayashi, Sumiyo Asakura, Yoshihiko Hirohashi, Makoto Meguro, Yasutoshi Kimura, Toshihiko Nishidate, Kenji Okita, Masaho Ishino, Atsushi Miyamoto, Masamitsu Hatakenaka, Noriyuki Sato, Koichi Hirata

SURGERY TODAY ( SPRINGER ) 46 ( 2 ) 139 - 148 2016.02

Book review, literature introduction, etc.

Pancreatic tumors are chemoresistant and malignant, and there are very few therapeutic options for pancreatic cancer, as the disease is normally diagnosed at an advanced stage. Although attempts have been made to develop vaccine therapies for pancreatic cancer for a couple of decades, none of the resultant protocols or regimens have succeeded in improving the clinical outcomes of patients. We herein review vaccines tested within the past few years, including peptide, biological and multiple vaccines, and describe the three sets of criteria used to evaluate the therapeutic activity of vaccines in solid tumors.

Phase I clinical study of Survivin-derived peptide vaccine for patients with advanced gastrointestinal cancers

里見蕗乃, 島宏彰, 水口徹, 鳥越俊彦, 九冨五郎, 木村康利, 廣橋良彦, 田村保明, 塚原智英, 金関貴幸, 高橋あかり, 浅沼広子, 伊藤陽一, 林宏至, 杉田修, 佐藤昇志, 平田公一

北海道外科雑誌 = The Hokkaido journal of surgery ( 北海道外科学会 ) 60 ( 2 ) 181 - 183 2015.12

Synchronous Paget disease of the breast and axilla

Keiju Kobayashi, Yasuyuki Sumikawa, Yumiko Kikuchi, Yuji Kan, Junji Kato, Fukino Satomi, Hiroaki Shima, Goro Kutomi, Toshiharu Yamashita

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY ( MOSBY-ELSEVIER ) 72 ( 1 ) E44 - E45 2015.01

Rapid communication, short report, research note, etc. (scientific journal)

Breast cancer under special conditions

九冨五郎, 島宏彰, 里見蕗乃

北海道外科雑誌 ( 北海道外科学会 ) 59 ( 2 ) 2 - 9 2014.12

期待される最新研究膵癌に対するサバイビン免疫療法の研究

腫瘤形成を示す浸潤性小葉癌のMMG所見の検討

島宏彰, 九冨五郎, 里見蕗乃, 高丸智子, 前田豪樹, 西堀重樹, 縫明大, 鈴木やすよ, 亀嶋秀和, 大村東生, 平間敏憲, 長谷川匡, 平田公一

日本臨床外科学会雑誌 ( 日本臨床外科学会 ) 75 ( 9 ) 2654 - 2655 2014.09

釣田義一郎, 谷澤健太郎, 篠崎大, 安井寛, 今井浩三, 石井浩, 尾阪将人, 島宏彰, 水口徹, 林宏至, 鳥越俊彦, 佐藤昇志

膵・胆道癌Frontier ( (株)メディカルレビュー社 ) 4 ( 2 ) 96 - 101 2014.09