研究者詳細 - 齊藤　秀和

論文 - 齊藤　秀和

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Effects of Go/NoGo stimulus ratio on reaction time, prestimulus preparatory activity, and poststimulus cognitive processing.

Yuya Matsuda, Mayu Akaiwa, Hidekazu Saito, Satoshi Kudoh, Yasushi Sugawara, Ryo Kurokawa, Rin Kosuge, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara

Experimental brain research 243 ( 6 ) 142 - 142 2025年05月 [国際誌]

Reaction time (RT) tasks are used extensively to evaluate sensory-motor function for basic research and various clinical applications, so it is critical to identify methodological and environmental factors influencing RT. Further, changes in RT under different conditions may reveal novel aspects of sensory-motor processing. Previous studies have reported that RTs on Go/NoGo tasks can be modulated by changes in Go/NoGo stimulus ratio, potentially by influencing prestimulus preparatory activity and (or) poststimulus cognitive processing. To assess the underlying mechanisms, we measured RT in an S1-S2 version of the Go/NoGo task in which a warning stimulus (S1) preceded Go and NoGo stimuli (S2) delivered at two ratios (Go and NoGo frequencies), NoGo-Rare (25% NoGo/75% Go) and NoGo-Frequent (75% NoGo/25% Go). Simultaneous electroencephalographic recordings were acquired of the contingent negative variation (CNV) as a preparatory activity marker and both NoGoN2 and NoGoP3 as cognitive processing markers. Mean RT was shorter during the NoGo-Rare condition compared to the NoGo-Frequent condition, but there were no significant differences in CNV amplitudes between conditions. Alternatively, significant differences were observed in NoGoN2 amplitude, NoGoN2 latency, and NoGoP3 amplitude between conditions, suggesting that Go/NoGo stimulus ratio alters RT primarily by influencing poststimulus cognitive processing.

DOI PubMed

Association Between Occupational Participation and Quality of Life in Japanese Older Adults

Suguru Shimokihara, Kazuki Yokoyama, Hikaru Ihira, Yuriko Matsuzaki-Kihara, Atsushi Mizumoto, Hideyuki Tashiro, Hidekazu Saito, Keitaro Makino, Kiyotaka Shimada, Kosuke Yama, Ryo Miyajima, Takeshi Sasaki, Nozomu Ikeda

OTJR: Occupational Therapy Journal of Research ( SAGE Publications ) 2025年03月

Positive associations between occupational participation and quality of life (QoL) are known in various populations, but there are few reports in older adults in Japan. To quantify the association between occupational participation in meaningful occupations and QoL among Japanese community-dwelling older adults. A self-administered questionnaire was sent to 626 older adults. QoL was assessed using the World Health Organization (WHO)-five well-being index, and occupational participation in meaningful occupations was measured with the self-administered occupational performance index. The association between occupational participation and QoL was analyzed. Among 367 participants, significant associations were found between occupational participation in meaningful occupations and QoL. In addition, participants with lower QoL exhibited lower levels of occupational participation in occupational control, occupational balance, and satisfaction of performance domains. There is a positive association between occupational participation and QoL among Japanese older adults. Occupational therapists should prioritize occupational participation to support the well-being of older adults.

DOI

Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency

Mayu Akaiwa, Ryo Kurokawa, Yuya Matsuda, Yasushi Sugawara, Rin Kosuge, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara

Neuroscience Research 2025年03月

DOI

Association Between the Use of Information and Communication Technology Tools and Each Domain of Cognitive Function Among Community-Dwelling Older Adults: A Prospective Cohort Study

Kazuki Yokoyama, Hikaru Ihira, Suguru Shimokihara, Yuriko Matsuzaki-Kihara, Atsushi Mizumoto, Hideyuki Tashiro, Hidekazu Saito, Keitaro Makino, Shunpei Katsuura, Kiyotaka Shimada, Kosuke Yama, Ryo Miyajima, Takeshi Sasaki, Nozomu Ikeda

Cureus ( Springer Science and Business Media LLC ) 2025年02月

DOI

Effects of Complex Movement on the Excitability of the Ipsilateral Primary Motor Cortex and Spinal Motoneurons Contralateral to the Movement: A Comparison of Ball Rotation and Grasping Tasks with Equivalent Muscle Activity

Rin Kosuge, Takehiro Sukegawa, Mayu Akaiwa, Eriko Shibata, Ryo Kurokawa, Yasushi Sugawara, Satoshi Kudoh, Yuya Matsuda, Hidekazu Saito, Takeshi Sasaki, Kazuhiro Sugawara

Brain Sciences 2025年02月

DOI

Development of Line Bisection Task Software Using a Tablet PC

Sanada Hirofumi, Takezawa Megumi, Ota Hisaaki, Saito Hidekazu

IEEJ Transactions on Electronics, Information and Systems ( The Institute of Electrical Engineers of Japan ) 145 ( 1 ) 122 - 123 2025年01月

This study presents the development of a tablet PC-based Line Bisection Task (LBT) software. The software was created through an iterative process involving collaboration between software developers and occupational therapy researchers, incorporating user feedback to refine the prototype. The resulting software addresses the limitations of traditional paper-and-pencil LBT methods, underscoring the value of interdisciplinary collaboration in healthcare technology development. The software offers several advantages over paper-and-pencil LBT, including enhanced flexibility, improved efficiency, real-time feedback, and reduced risk of human error. This tablet-based LBT software is expected to provide an efficient and effective tool for assessing spatial perception.

DOI

Linear association between frailty as assessed by the Kihon Checklist and quality of life in community-dwelling older adults: A cross-sectional population-based study

Annals of Geriatric Medicine and Research ( The Korean Geriatrics Society ) 2024年10月

DOI

上肢機能評価に用いられる評価バッテリーの使用に関する現状と課題

齊藤秀和, 横山和樹, 勝浦駿平, 太田久晶

作業療法ジャーナル ( (株)三輪書店 ) 58 ( 11 ) 1115 - 1122 2024年10月 [査読有り]

担当区分：筆頭著者 , 責任著者

＜文献概要＞上肢機能評価バッテリーの使用状況について,アンケート調査で得られた結果から,上肢機能評価の現状と問題点を明らかにし,その対応を検討した.北海道内の病院等に所属する作業療法部門代表者に郵送式のアンケート調査を実施し,対象疾患に脳卒中または脳損傷を含む75施設を分析対象とした.その結果,上肢機能評価バッテリーの使用・不使用理由として,評価バッテリー・物品の保有,未保有・不足の影響が大きいことが明らかとなり,評価に対する知識・技術不足も不使用の理由として挙げられた.また臨床現場では,ADL上の実動作に関する上肢機能評価の必要性を感じていることが明らかとなった.以上より,上肢機能評価についての知識・技術の指導や,新たな評価バッテリー開発によって,作業療法技術向上や円滑な治療介入につながる可能性が示唆された.

Low blood concentration of alcohol enhances activity related to stopping failure in the right inferior frontal cortex

Jun Shinozaki, Hiroshi Matsumoto, Hidekazu Saito, Takashi Murahara, Hiroshi Nagahama, Yuuki Sakurai, Takashi Nagamine

Cerebral cortex (New York, N.Y. : 1991) ( Cold Spring Harbor Laboratory ) 34 ( 3 ) 2024年05月 [国際誌]

ABSTRACT This study investigated the effects of low doses of alcohol, which are acceptable for driving a car, on inhibitory control and neural processing using the stop-signal task (SST) in 17 healthy right-handed social drinkers. The study employed simultaneous functional magnetic resonance imaging and electromyography (EMG) recordings to assess behavioural and neural responses under conditions of low-dose alcohol (breath-alcohol concentration of 0.15 mg/L) and placebo. The results demonstrated that even a small amount of alcohol consumption prolonged Go reaction times in the SST and modified stopping behaviour, as evidenced by a decrease in the frequency and magnitude of partial response EMG that did not result in button pressing during successful inhibitory control. Furthermore, alcohol intake enhanced neural activity during failed inhibitory responses in the right inferior frontal cortex, suggesting its potential role in behavioural adaptation following stop-signal failure. These findings suggest that even low levels of alcohol consumption within legal driving limits can greatly impact both the cognitive performance and brain activity involved in inhibiting responses. This research provides important evidence on the neurobehavioural effects of low-dose alcohol consumption, with implications for understanding the biological basis of impaired motor control and decision-making and potentially informing legal guidelines on alcohol consumption.

DOI PubMed

Does 20 Hz Transcranial Alternating Current Stimulation over the Human Primary Motor Cortex Modulate Beta Rebound Following Voluntary Movement?

Mayu Akaiwa, Yuya Matsuda, Ryo Kurokawa, Yasushi Sugawara, Rin Kosuge, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara, Naoki Kozuka

Brain sciences 14 ( 1 ) 2024年01月 [国際誌]

Beta frequency oscillations originating from the primary motor cortex increase in amplitude following the initiation of voluntary movement, a process termed beta rebound. The strength of beta rebound has been reported to predict the recovery of motor function following stroke, suggesting therapeutic applications of beta rebound modulation. The present study examined the effect of 20 Hz transcranial alternating current stimulation (tACS) on the beta rebound induced by self-paced voluntary movement. Electroencephalograms (EEGs) and electromyograms (EMGs) were recorded from 16 healthy adults during voluntary movements performed before and after active or sham tACS. There was no significant change in average beta rebound after active tACS. However, the beta rebound amplitude was significantly enhanced in a subset of participants, and the magnitude of the increase across all participants was negatively correlated with the difference between individual peak beta frequency and tACS frequency. Thus, matching the stimulus frequency of tACS with individual beta frequency may facilitate therapeutic enhancement for motor rehabilitation.

DOI PubMed

Validity and Reliability Study of a Line Bisection Task on Tablet Personal Computer

Ota Hisaaki, Sanada Hirofumi, Takeuchi Toshiki, Takezawa Megumi, Saito Hidekazu, Katsuura Shunpei, Iida Akihiro

Asian Journal of Occupational Therapy ( Japanese Association of Occupational Therapists ) 20 ( 1 ) 142 - 148 2024年

Objective: Recently, we developed a line bisection task (LBT) that could be performed on a tablet personal computer (PC) by recording the results and automatically calculating the lateral deviation from the true center for each trial. The present study aimed to verify the validity and reliability of the LBT on a tablet PC. Additionally, we examined whether there were any differences between the results of the tablet and paper LBTs. Methods: The LBT was performed both on paper and tablet PC by 26 right-handed healthy adult volunteers (mean age 21.2 ± 2.1 years). Lines of three different lengths (200, 100, and 50 mm) were presented five-times in a pseudorandom order in each task condition. The participants were asked to mark a subjective midpoint with a pencil or a dedicated pen. Additionally, eight participants performed the LBT on the tablet twice to evaluate reliability. Results: Data analysis revealed a significant and “strong” to “very strong” correlation between the results of paper and tablet LBTs for each line length. Additionally, “good” test-retest reliability was confirmed by the results of the tablet LBT. There was no difference in the LBT results for each line length between the two task conditions. Conclusions: The validity and reliability of the newly developed tablet LBT were confirmed. Additionally, the LBT performed on the tablet PC yielded results equivalent to those obtained when performed on paper.

DOI

Event-Related Brain Potentials N140 and P300 during Somatosensory Go/NoGo Tasks Are Modulated by Movement Preparation.

Yuya Matsuda, Yasushi Sugawara, Mayu Akaiwa, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara

Brain sciences 14 ( 1 ) 2023年12月 [国際誌]

The Go/NoGo task requires attention and sensory processing to distinguish a motor action cue or 'Go stimulus' from a 'NoGo stimulus' requiring no action, as well as motor preparation for a rapid Go stimulus response. The neural activity mediating these response phases can be examined non-invasively by measuring specific event-related brain potentials (ERPs) using electroencephalography. However, it is critical to determine how different task conditions, such as the relationship between attention site and movement site, influence ERPs and task performance. In this study, we compared attention-associated ERP components N140 and P300, the performance metrics reaction time (RT) and accuracy (%Error) and movement-related cortical potentials (MRCPs) between Go/NoGo task trials in which attention target and movement site were the same (right index finger movement in response to right index finger stimulation) or different (right index finger movement in response to fifth finger stimulation). In other Count trials, participants kept a running count of target stimuli presented but did not initiate a motor response. The N140 amplitudes at electrode site Cz were significantly larger in Movement trials than in Count trials regardless of the stimulation site-movement site condition. In contrast, the P300 amplitude at Cz was significantly smaller in Movement trials than in Count trials. The temporal windows of N140 and P300 overlapped with the MRCP. This superposition may influence N140 and P300 through summation, possibly independent of changes in attentional allocation.

DOI PubMed

脳卒中ドライバーのスクリーニング評価日本版(J-SDSA)における健常高齢者の成績特性および,運転に関する自記式調査との関連性についての検討

勝浦駿平, 齊藤秀和, 太田久晶

日本安全運転医療学会誌 ( 日本安全運転医療学会 ) 3 ( 1 ) 49 - 58 2023年07月

【背景】運転技能に関する認知機能評価の一つである「脳卒中ドライバーのスクリーニング評価日本版」(J-SDSA)について,健常高齢者における成績特性を詳細に検討した報告はない.そこで,本研究では,健常高齢者群におけるJ-SDSAの成績特性を明らかにした上で,本課題成績と運転に関する自記式調査との関連性を検討した.【方法】参加者は,本邦の運転免許を保有する,60歳から77歳までの健常高齢者80名であった.参加者に対しJ-SDSAを実施し,課題成績を集計した.さらに,筆者らが作成した,運転に関する自記式調査票により,参加者の運転経験,事故・違反・ヒヤリハット歴,運転技能の自己評価についての情報を収集し,J-SDSAの課題成績との関連性を分析した.【結果】健常高齢者におけるJ-SDSAの課題成績は,健常若年者群のそれよりも低く,原著版SDSAの健常高齢者群よりも良好な成績であった.4名の参加者は,合否判定の予測式により不合格と判定された.本課題成績は,参加者の事故・違反・ヒヤリハット件数とは関連しないが,走行距離及び,安全運転に関する自己評価と関連することが明らかとなった.【結論】J-SDSAにおける健常高齢者の成績特性を示した.本研究結果は,同年代の脳損傷者に対し本課題を実施した際に,正常範囲のデータとして参照可能と考える.(著者抄録)

Effects of repetitive practice of motor tasks on somatosensory gating.

Mayu Akaiwa, Yuya Matsuda, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara

Frontiers in human neuroscience 17 1131986 - 1131986 2023年 [国際誌]

INTRODUCTION: During voluntary muscle contraction, the amplitude of the somatosensory evoked potential (SEP) is reduced by inhibiting sensory information from a peripheral nerve supplying the contracted muscle. This phenomenon is called "gating." We reported that participants with good motor skills indicated strong suppression of somatosensory information. The present study investigated the effects of motor performance improvement following repetitive practice on the SEP amplitude. METHODS: The ball rotation task (BR task) was practiced by 15 healthy participants repetitively. SEPs were recorded before (pre) and after (post) repetitive practice. RESULTS: The BR task performance was significantly improved and the required muscle activation to perform the task was significantly reduced after the repetitive practice. The degree of gating was not significant between pre and post- for the SEP amplitude. A significant correlation was found between changes in SEP amplitude from pre to post and performance improvement. DISCUSSION: After repetitive practice, the degree of gating did not change, but the performance of the BR task improved, and the muscle activity required for the BR task decreased. These results suggest that repetitive practice does not change the degree of gating but changes the mechanism of gating. Furthermore, they indicate that suppression of the somatosensory area may play a role in improving task performance.

DOI PubMed

Movement of the stimulated finger in a Go/NoGo task enhances attention directed to that finger as evidenced by P300 amplitude modulation.

Kazuhiro Sugawara, Mayu Akaiwa, Yuya Matsuda, Eriko Shibata, Hidekazu Saito, Takeshi Sasaki

Frontiers in human neuroscience 17 1178509 - 1178509 2023年 [国際誌]

Somatosensory cues and the optimal allocation of attentional resources are critical for motor performance, but it is uncertain how movement of a body part modulates directed attention and the processing of somatosensory signals originating from that same body part. The current study measured motor reaction time (RT) and the P300 event-related potential during a required movement response to stimulation of the same body part in a Go/NoGo task under multiple response. In the Movement Condition, participants were instructed to extend their right index finger in response to mild electrical stimulation of the same finger (Go signal) or remain still when receiving electrical stimulation to the fifth right finger (NoGo signal). Movement RTs and P300 amplitudes and latencies were measured under varying Go signal 50% probabilities. In other trial blocks, participants were required to count Go signals but not respond with movement or to ignore all signals while engaged in an unrelated task. Mean RT in the Movement Condition was 234.5 ms. P300 response amplitudes at midline electrodes (Fz, Cz, Pz) were the largest in the Movement Condition. The P300 amplitude at parietal electrode site Pz was significantly greater during Movement Condition trials than during Count Condition trials. The increase in P300 amplitude during trials requiring movement of the same body part receiving somatosensory stimulation suggests that movement itself modulates the attentional resources allocated to that body part.

DOI PubMed

Prism Adaptation Induces Allocentric Neglect-Like Behavior in Healthy Participants

Takeuchi Toshiki, Saito Hidekazu, Ota Hisaaki

Asian Journal of Occupational Therapy ( Japanese Association of Occupational Therapists ) 19 ( 1 ) 117 - 123 2023年

Introduction: Prism adaptation (PA) is a promising treatment to improve unilateral spatial neglect (USN). Egocentric neglect and allocentric neglect are the two types of USN in terms of spatial reference frames, but no study was reported the PA affects allocentric frame selectively. This study therefore aimed to investigate whether the PA effect could be observed only on allocentric frame in healthy participants. Method: Thirty right-handed participants (12 females and 18 males, mean age 22.6 years), wore the right wedged prismatic glasses that created an optical shift of 5.7° to the left. They were asked to reach two visual targets with the right index finger 100 times alternately. Outcomes were measured through the line bisection task where lines of two different lengths (200 mm and 50 mm) were presented one by one in front of or on the left or right side of the participants. Results: The subjective midpoint on the 200-mm line shifted significantly to the right after the PA, but not on the 50-mm line. Additionally, the degree of rightward deviation was not affected by the position of the presented line regardless of its length. Discussion: These results indicate that the PA task induced allocentric neglect-like behavior. Hence, PA affected only the allocentric frame among healthy participants. The results of this study may contribute to the evaluation and treatment of allocentric neglect.

DOI

右手のリーチ・把持動作と道具使用に拙劣さを呈した左前頭葉・頭頂葉膠芽腫の1例

勝浦駿平, 太田久晶, 齊藤秀和, 若松千裕, 石合純夫

臨床神経心理 ( 東北神経心理懇話会 ) 33 1 - 10 2022年12月

右手動作に特徴的な拙劣さを呈した左前頭葉・頭頂葉膠芽腫例の作業療法を担当する機会を得た。症例は、60歳代前半の右利き男性、膠芽腫であった。神経学的所見として、軽度の右片麻痺、右下四分盲を認め、神経心理学的所見として、重度の超皮質性感覚失語、失行症を認めた。術後に生じた、右手動作の特徴的な所見として、上肢や手指の分離運動など、対象のない条件下での動作は良好である一方、リーチ動作や把持動作、道具使用のように、操作対象のある動作で拙劣さを示した。リーチ動作では、動作が緩慢で対象への到達に時間を要し、把持動作では対象に合わせた把持形態をとることが困難であった。道具使用の場面では、対象に対して適切な位置での操作が困難であった。これらの右手における動作拙劣の要因として、頭頂間溝領域を含む頭頂葉病変による、視覚情報に基づいたリーチ・把持動作の障害、感覚情報の利用障害、および、前頭前野を含む前頭葉病変による、動作の選択・企図の障害の関与が考えられた。(著者抄録)

The relationships between motor behavior and sensory gating in the ball rotation task.

Mayu Akaiwa, Yuya Matsuda, Yuta Soma, Eriko Shibata, Hidekazu Saito, Takeshi Sasaki, Kazuhiro Sugawara

Experimental brain research 240 ( 10 ) 2659 - 2666 2022年10月 [国際誌]

During voluntary muscle contraction, sensory information induced by electrostimulation of the nerves supplying the contracting muscle is inhibited and the amplitude of the corresponding somatosensory evoked potential (SEP) decreases. This phenomenon is called "gating." The reduction of the SEP amplitude is reportedly significantly larger when task performance is high. However, the relationship between dexterous movement skills and gating remains unclear. In this study, we investigated through a ball rotation (BR) task how dexterous movement skills affect the SEP amplitudes. Thirty healthy subjects performed the BR task comprising the rotation of two wooden balls as quickly as possible. We estimated the median number of ball rotations for each participant and classified the participants into two (fast and slow) groups based on the results. Moreover, we recorded SEPs, while the subjects performed BR tasks or rested. SEP amplitude reduction (P45) was significantly larger in the fast than in the slow group. We also observed that the P45 amplitude during the BR task was attenuated even more so in the case of the participants with better dexterous movement skills. Our results suggest that the participants with better dexterous movement skills might display stronger somatosensory information suppression because of increasing the motor cortex activity and the afferent input during the BR task.

DOI PubMed

Influences of COVID-19 pandemic and the states of emergency on occupational therapy for physical disorders: A questionnaire survey in Hokkaido, Japan

Hidekazu Saito, Kazuki Yokoyama, Takafumi Morimoto, Hisaaki Ota, Nozomu Ikeda

Hong Kong Journal of Occupational Therapy ( SAGE Publications ) 35 ( 2 ) 156918612211215 - 156918612211215 2022年09月 [査読有り] [国際誌]

担当区分：筆頭著者 , 責任著者

Objective: This study aimed to explore the influence of coronavirus disease-2019 (COVID-19) on occupational therapy (OT) for physical disorders, including changes in the assessment, treatment, other restrictions, and measures of OT. Methods: A questionnaire survey was conducted among occupational therapists working in Hokkaido, Japan, and 123 out of the 334 (36.8%) were from OT facilities that target physical disorders. The responses were classified the categories and codes by [ ] and < >, respectively. Results: The number of patients decreased in 47.1% of the OT facilities after the pandemic declaration. Only one facility reported <decrease in intervention with palpation>. Therefore, [thoroughness of standard precautions] including <disinfection of materials and common use areas>, <hand hygiene>, and [changes in treatment structure] including <restriction on use of materials> were implemented. Additionally, there were not only [restrictions on participation of patients] and [restrictions on outpatient services], but also [restrictions on operations of OT], such as <cancellation or change of the methods of meetings and workshops> and so on. Furthermore, [changes in treatment structure] and [setting criteria for discontinuation of participation] were utilized in some facilities to prevent and to reduce the risk of infection. Conclusions: By revisiting the assessment and treatment guidelines on infection control, it is possible to provide continuous OT services and to tackle the challenges posed by the pandemic.

DOI PubMed

右方偏倚プリズム眼鏡を用いた反復到達運動課題は，それに続く左方偏倚プリズム眼鏡を用いた同課題の順応効果に影響を及ぼすのか？：健常若年者を対象とした前臨床研究

竹内利貴, 太田久晶, 齊藤秀和

札幌保健科学雑誌 ( 11 ) 31 - 37 2022年03月

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