研究者詳細 - 宇原　久

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末端黒子型黒色腫における腫瘍浸潤リンパ球の単細胞免疫プロファイリング

箕輪智幸, 箕輪智幸, 村田憲治, 廣橋良彦, 宇原久, 鳥越俊彦

日本病理学会会誌 112 ( 1 ) 2023年

MYO5A-NTRK3融合遺伝子を検出したatypical Spitz tumor

佐藤さゆり, 肥田時征, 井戸川雅史, 黄倉真恵, 宇原久

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 132 ( 5 ) 1363 - 1363 2022年05月

カスタムパネルシーケンスを用いた日本人メラノーマのドライバー遺伝子の検出

肥田時征, 井戸川雅史, 堀本浩平, 加藤潤史, 佐藤さゆり, 藤岡茉生, 丹下正一朗, 時野隆至, 宇原久

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 131 ( 5 ) 1363 - 1363 2021年05月

病理組織学的に顕著なロゼット様構造を呈したALK陽性atypical Spitz tumor

箕輪智幸, 肥田時征, 堀本浩平, 加藤潤史, 神谷崇文, 杉田真太朗, 井戸川雅史, 宇原久

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 131 ( 5 ) 1417 - 1417 2021年05月

Immunotherapy for advanced melanoma: Current situation in Japan

Junji Kato, Hisashi Uhara

Japanese Journal of Clinical Oncology ( Oxford University Press ) 51 ( 1 ) 3 - 9 2021年01月

書評論文，書評，文献紹介等

Treatment with immune checkpoint inhibitors provides long-term survival for patients with advanced melanoma. Improvements in the overall survival of advanced melanoma patients have been achieved with anti-PD-1 monotherapy and anti-PD-1+ CTLA4 combination therapy, but there are still many issues to resolve. Acral, mucosal and uveal melanoma have been less responsive to immune checkpoint inhibitors than cutaneous melanoma. For patients who have achieved a good response, it is still not known how long the anti-PD-1 therapy should be administered. Moreover, there is limited treatment for patients who relapse during or after adjuvant anti-PD-1 therapy. Here, we review the current evidence regarding the clinical effects of immunotherapy for advanced melanoma. Moreover, we review previous studies of acral, mucosal and uveal melanoma, and we discuss the recent findings regarding durable response after the cessation of anti-PD-1 therapy, and treatment options for recurrence after adjuvant therapy.

Cutaneous apocrine carcinoma with elevated serum cytokeratin 19 fragment 21-1 (CYFRA 21-1)

Mao Fujioka, Junji Kato, Yasuyuki Sumikawa, Sayuri Sato, Masahide Sawada, Hisashi Uhara

Journal of Dermatology ( Blackwell Publishing Ltd ) 46 ( 10 ) e387 - e388 2019年10月

速報，短報，研究ノート等（学術雑誌）

Efficacy and management of adverse events of ipilimumab including combination therapy with nivolumab

Hisashi Uhara, Eijun Itakura

Japanese Journal of Cancer and Chemotherapy ( Japanese Journal of Cancer and Chemotherapy Publishers Inc. ) 46 ( 6 ) 1017 - 1026 2019年06月

書評論文，書評，文献紹介等

The treatment of cancer has been greatly improved in recent years by immune checkpoint inhibitors. Anti-CTLA-4 and anti-PD-1 antibodies, two types of immune checkpoint inhibitors, have great potential to prolong survival, while they have different characteristics of efficacy and safety profiles. Combination therapy with the anti-CTLA-4 antibody ipilimumab and the anti-PD-1 antibody nivolumab has better efficacy than monotherapy. On the other hand, immune checkpoint inhibitors can result in a wide variety of immune-related adverse events (irAEs), which should be carefully managed. Such irAE includes that of the gastrointestinal tract, liver, and endocrine system, and is increased in incidence and severity when combined with ipilimumab and nivolumab. It is known that clinical characteristics of irAEs are different from those of typical autoimmune diseases. Therefore, irAEs should be managed in line with the algorithms and the appropriate use guides specifically for these drugs.

Real-world efficacy of anti-PD-1 antibodies in advanced acral melanoma patients: A retrospective, multicenter study (JAMP study).

Yasuhiro Nakamura, Kenjiro Namikawa, Koji Yoshino, Shusuke Yoshikawa, Hiroshi Uchi, Katsunobu Goto, Yoshiyuki Nakamura, Satoshi Fukushima, Yukiko Kiniwa, Tatsuya Takenouchi, Hisashi Uhara, Toru Kawai, Naohito Hatta, Takeru Funakoshi, Yukiko Teramoto, Atsushi Otsuka, Haruki Doi, Dai Ogata, Shigeto Matsushita, Naoya Yamazaki

JOURNAL OF CLINICAL ONCOLOGY ( AMER SOC CLINICAL ONCOLOGY ) 37 ( 15 ) 2019年05月

研究発表ペーパー・要旨（国際会議）

悪性黒色腫(1)悪性黒色腫と色素細胞母斑の病理組織学的鑑別 (特集皮膚悪性腫瘍の病理組織診断プラクティス)

神谷崇文, 宇原久

デルマ ( 全日本病院出版会 ) ( 280 ) 44 - 50 2019年03月

根治切除不能な化学療法未治療の悪性黒色腫を対象としたニボルマブ国内第II相試験(ONO-4538-08)長期追跡

清原祥夫, 山崎直也, 宇原久, 上原治朗, 藤本学, 竹之内辰也, 大塚正樹, 内博史, 尹浩信, 南博信

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 ( (一社)日本皮膚悪性腫瘍学会 ) 34回 149 - 149 2018年06月

悪性黒色腫におけるニボルマブとイピリムマブの逐次的治療の臨床研究多施設後ろ向き観察研究

福島聡, 横田憲二, 清原祥夫, 山崎修, 種村篤, 奥山隆平, 宇原久, 片山輝昭, 板倉英潤, 堤田新

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 ( (一社)日本皮膚悪性腫瘍学会 ) 34回 163 - 163 2018年06月

日本人進行性悪性黒色腫患者を対象としたペムブロリズマブの第Ib相試験の最終解析

藤澤康弘, 横田憲二, 竹之内辰也, 尹浩信, 内博史, 猪爪隆史, 清原祥夫, 宇原久, 山崎直也

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 ( (一社)日本皮膚悪性腫瘍学会 ) 34回 149 - 149 2018年06月

直腸癌の多発皮膚転移

加瀬貴美, 加藤潤史, 澄川靖之, 肥田時征, 杉田真太朗, 宇原久

西日本皮膚科 ( 日本皮膚科学会-西部支部 ) 80 ( 3 ) 181 - 182 2018年06月

悪性黒色腫と色素細胞母斑の病理組織学的鑑別 (特集形成外科医のための皮膚病理講座にようこそ)

神谷崇文, 宇原久

Pepars ( 全日本病院出版会 ) ( 132 ) 69 - 77 2017年12月

【がん転移学(上)-がん転移のメカニズムと治療戦略:その基礎と臨床-】がん転移学の基礎研究がんの発生進展の分子機構皮膚悪性黒色腫の分子遺伝学

肥田時征, 加藤潤史, 宇原久

日本臨床 ( (株)日本臨床社 ) 75 ( 増刊8 がん転移学(上) ) 246 - 251 2017年11月

Clinical and genetic characteristics of cutaneous melanoma with clinical history of early childhood onset

A. Minagawa, H. Uhara, K. Sakaizawa, H. Koga, A. Ashida, R. Okuyama

JOURNAL OF INVESTIGATIVE DERMATOLOGY ( ELSEVIER SCIENCE INC ) 137 ( 10 ) S196 - S196 2017年10月

研究発表ペーパー・要旨（国際会議）

メラノーマ診療

加藤潤史, 肥田時征, 宇原久

皮膚病診療 ( (株)協和企画 ) 39 ( 9 ) 1002 - 1007 2017年09月

根治切除不能なIII/IV又は再発の化学療法未治療の悪性黒色腫を対象としたニボルマブ国内第II相試験の成績

清原祥夫, 山崎直也, 宇原久, 上原治朗, 藤本学, 竹之内辰也, 大塚正樹, 内博史, 尹浩信, 南博信

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 ( (一社)日本皮膚悪性腫瘍学会 ) 33回 120 - 120 2017年05月

KEYNOTE-041 日本人進行性悪性黒色腫患者を対象としたペムブロリズマブの第Ib相試験

竹之内辰也, 横田憲二, 藤澤康弘, 尹浩信, 内博史, 猪爪隆史, 清原祥夫, 宇原久, 山崎直也

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 ( (一社)日本皮膚悪性腫瘍学会 ) 33回 122 - 122 2017年05月

Serum 5-s-cysteinyldopa for identifying non-responders to nivolumab treatment of melanoma.

Toshikazu Omodaka, Akane Minagawa, Hisashi Uhara, Kazumasa Wakamatsu, Tomonobu Koizumi, Hiroshi Koga, Ryuhei Okuyama

JOURNAL OF CLINICAL ONCOLOGY ( AMER SOC CLINICAL ONCOLOGY ) 35 2017年05月

研究発表ペーパー・要旨（国際会議）

Orange pigmentation spots on the sole may be from a stink bug

Hisashi Uhara, Tasuku Sano, Tomomi Miyake, Ryuhei Okuyama

Journal of Dermatology ( Blackwell Publishing Ltd ) 43 ( 10 ) 1247 - 1248 2016年10月

速報，短報，研究ノート等（学術雑誌）

皮膚メラノーマ・他 KEYNOTE-041 進行性悪性黒色腫の日本人患者を対象としたMK-3475の第Ib相試験

横田憲二, 竹之内辰也, 藤本学, 尹浩信, 内博史, 猪爪隆史, 清原祥夫, 宇原久, 中川和彦, 古川洋志, 和田秀文, 野口一夫, 嶋本隆司, 山崎直也

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 ) 54回 WS30 - 1 2016年10月

5-Hydroxymethylcytosine as a putative marker for erosive adenomatosis of the nipple

Yuko Takazawa, Tomohiro Edamitsu, Kazuma Maeno, Eisaku Ogawa, Hisashi Uhara, Shigeo Kawachi, Ken-Ichi Ito, Ryuhei Okuyama

Journal of Dermatology ( Blackwell Publishing Ltd ) 43 ( 5 ) 579 - 580 2016年05月

速報，短報，研究ノート等（学術雑誌）

Inhibition of epidermal growth factor receptor induces tumor necrosis factor-α via activation of peroxisome proliferator-activated receptor-γ and nuclear factor-κB in sebocytes: A possible pathogenesis of papulopustular rash

Atsuko Ashida, Eisaku Ogawa, Hisashi Uhara, Tomonobu Koizumi, Ryuhei Okuyama

Journal of Dermatological Science ( Elsevier Ireland Ltd ) 82 ( 1 ) 53 - 56 2016年04月

速報，短報，研究ノート等（学術雑誌）

5-Hydroxymethylcytosine is a useful marker to differentiate between dermatofibrosarcoma protuberans and dermatofibroma

Y. Mikoshiba, E. Ogawa, R. Uchiyama, A. Uchiyama, H. Uhara, R. Okuyama

Journal of the European Academy of Dermatology and Venereology ( Blackwell Publishing Ltd ) 30 ( 1 ) 130 - 131 2016年01月

速報，短報，研究ノート等（学術雑誌）

A Place for BRAFV600E Mutation-specific Immunohistochemistry Alongside Cell-free DNA Mutation Detection in Melanoma Reply

Atsuko Ashida, Hisashi Uhara, Asuka Mikoshiba, Kaori Sakaizawa, Naomi Kumagai, Hiroshi Koga, Ryuhei Okuyama

ACTA DERMATO-VENEREOLOGICA ( ACTA DERMATO-VENEREOLOGICA ) 96 ( 3 ) 427 - 427 2016年

速報，短報，研究ノート等（学術雑誌）

Violaceous and Petechial Persistent Plantar Plaques: A Quiz

Atsuko Ashida, Hisashi Uhara, Asuka Mikoshiba, Kaori Sakaizawa, Naomi Kumagai, Hiroshi Koga, Ryuhei Okuyama

ACTA DERMATO-VENEREOLOGICA ( ACTA DERMATO-VENEREOLOGICA ) 96 ( 3 ) 427 - + 2016年

その他

Histopathological improvement of scleroderma induced by paclitaxel in a patient with breast cancer

Atsuko Ohashi, Akane Minagawa, Atsuko Ashida, Hiroshi Koga, Hisashi Uhara, Ryuhei Okuyama

JOURNAL OF DERMATOLOGY ( WILEY-BLACKWELL ) 42 ( 12 ) 1198 - 1199 2015年12月

速報，短報，研究ノート等（学術雑誌）

Phase II study of ipilimumab monotherapy in Japanese patients with advanced melanoma

N. Yamazaki, Y. Kiyohara, H. Uhara, S. Fukushima, H. Uchi, N. Shibagaki, A. Tsutsumida, S. Yoshikawa, R. Okuyama, Y. Ito, T. Tokudome

Cancer Chemotherapy and Pharmacology 76 ( 5 ) 997 - 1004 2015年11月 [査読有り] [ 国際誌 ]

© 2015 The Author(s). Purpose: Ipilimumab is designed to block cytotoxic T-lymphocyte antigen-4 to augment antitumor T cell responses. In studies of predominantly Caucasian patients with advanced melanoma, ipilimumab was associated with durable response, long-term survival benefit, and a manageable safety profile. This phase II study assessed the safety of ipilimumab in Japanese patients with unresectable stage III or IV melanoma. Methods: Patients received ipilimumab 3 mg/kg every 3 weeks for four doses. The database lock for the original analysis was in August 2014. Overall survival, progression-free survival, and data on deaths were based on an updated, follow-up analysis (database lock April 2015). Results: Data are reported from 20 patients. Fifteen patients (75 %) received all four doses of ipilimumab during induction. Twelve patients (60 %) had at least one drug-related adverse event (AE), and no patients discontinued due to a drug-related AE. There were no deaths related to study drug. The most common drug-related AEs were rash (n = 7), pyrexia (n = 3), increased aspartate aminotransferase (AST; n = 3), and increased alanine aminotransferase (ALT; n = 3). Twelve patients (60 %) reported immune-related AEs (irAEs); most frequent were skin (n = 9) and liver (n = 3) disorders. Grade 3 irAEs were ALT and AST elevation (n = 2) and diabetes mellitus (n = 1). Two patients had a partial response and two had stable disease, yielding a 20 % disease control rate. Median overall survival and progression-free survival were 8.71 and 2.74 months, respectively. Conclusion: Ipilimumab 3 mg/kg had a manageable AE profile in this Japanese patient population with clinical outcomes similar to that in Caucasian patients. ClinicalTrials.gov identifier: NCT01990859.

Brown nodule on the lower eyelid: A quiz

Shiho Shirota, Akane Minagawa, Hiroshi Koga, Masanobu Momose, Hisashi Uhara, Ryuhei Okuyama

Acta Dermato-Venereologica ( Medical Journals/Acta D-V ) 95 ( 8 ) 1037 2015年11月

速報，短報，研究ノート等（学術雑誌）

Primary cutaneous nocardiosis caused by Nocardia concava

Kenta Nakamura, Fuminao Kamijo, Tatsuya Negishi, Takehisa Matsumoto, Ryuhei Okuyama, Hisashi Uhara

Journal of Dermatology ( Blackwell Publishing Ltd ) 42 ( 11 ) 1121 - 1122 2015年11月

速報，短報，研究ノート等（学術雑誌）

Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma

N. Yamazaki, H. Uhara, S. Fukushima, H. Uchi, N. Shibagaki, Y. Kiyohara, A. Tsutsumida, K. Namikawa, R. Okuyama, Y. Otsuka, T. Tokudome

Cancer Chemotherapy and Pharmacology 76 ( 5 ) 969 - 975 2015年11月 [査読有り] [ 国際誌 ]

© 2015 The Author(s). Purpose: Ipilimumab (IPI), a monoclonal antibody against immune-checkpoint receptor cytotoxic T lymphocyte antigen-4, is designed to enhance antitumor T cell function. IPI 10 mg/kg plus dacarbazine (DTIC) significantly improved overall survival in a phase 3 study involving predominantly Caucasian patients, with an adverse event (AE) profile similar to that of IPI monotherapy. We conducted a single-arm, phase 2 study to evaluate the safety and efficacy of IPI plus DTIC in Japanese patients. Methods: Previously untreated patients with unresectable stage III or IV melanoma received IPI 10 mg/kg plus DTIC 850 mg/m2 every 3 weeks for four doses (q3w × 4), followed by DTIC q3w × 4 and then IPI every 12 weeks until disease progression or intolerable toxicity. Results: All 15 treated patients reported drug-related AEs, the most common of which were increases in alanine aminotransferase (n = 12, 80 %) and aspartate aminotransferase (n = 11, 73 %). Treatment-related serious AEs were reported in 11 (73 %) patients. Nine patients (60 %) discontinued treatment due to drug-related toxicities. Immune-related AEs (irAEs) were reported in 14 patients (93 %). The most frequent irAEs were liver (n = 12, 80 %) and skin (n = 10, 67 %) toxicities. Five deaths were reported; all were caused by progressive disease. Efficacy evaluation showed one complete response, one partial response and four patients with stable disease. Best overall response rate was 13 % (2/15), and the disease control rate was 40 % (6/15). The study was terminated early due to frequent, high-grade liver toxicities. Conclusions: IPI 10 mg/kg plus DTIC 850 mg/m2 was not considered tolerable in the Japanese patient population. ClinicalTrials.gov identifier: NCT01681212.

The role of sentinel lymph node biopsy in the management of invasive extramammary Paget's disease: multi-center, retrospective study of 151 patients (vol 79, pg 38, 2015)

Yasuhiro Fujisawa, Koji Yoshino, Yoshio Kiyohara, Takafumi Kadono, Yozo Murata, Hisashi Uhara, Naohito Hatta, Hiroshi Uchi, Shigeto Matsushita, Tatsuya Takenouchi, Toshihiko Hayashi, Manabu Fujimoto, Kuniaki Ohara

JOURNAL OF DERMATOLOGICAL SCIENCE ( ELSEVIER IRELAND LTD ) 80 ( 1 ) 79 - 79 2015年10月

その他

Phase 2 study of Nivolumab (Anti-PD-1; ONO-4538/BMS-936558) in Japanese patients with advanced melanoma: Preliminary report

N. Yamazaki, Y. Kiyohara, H. Uhara

EUROPEAN JOURNAL OF CANCER ( ELSEVIER SCI LTD ) 51 S110 - S110 2015年09月

研究発表ペーパー・要旨（国際会議）

皮膚がん分子標的治療の現状と新薬開発状況 (特集固形がんの分子標的薬 : 基礎研究から創薬・開発・臨床まで) -- (疾患・臓器からみた固形がん分子標的治療)

宇原久

日本臨床 ( 日本臨床社 ) 73 ( 8 ) 1391 - 1397 2015年08月

進行期悪性黒色腫におけるipilimumabの2つの国内第2相試験における安全性マネージメント

宇原久, 山崎直也, 清原祥夫, 内博史, 福島聡, 柴垣直孝, 堤田新, 奥山隆平, 吉川周佐, 並川健二郎, 徳留拓人

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 ( 日本皮膚悪性腫瘍学会 ) 31回 149 - 149 2015年07月

進行期悪性黒色腫患者におけるipilimumab単独療法第2相臨床試験

福島聡, 清原祥夫, 宇原久, 内博史, 柴垣直孝, 堤田新, 吉川周佐, 奥山隆平, 伊藤嘉紀, 山崎直也

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 ( 日本皮膚悪性腫瘍学会 ) 31回 149 - 149 2015年07月

化学療法未治療進行期悪性黒色腫患者におけるipilimumabのDTIC併用国内第2相臨床試験

内博史, 宇原久, 福島聡, 柴垣直孝, 清原祥夫, 堤田新, 奥山隆平, 並川健二郎, 大塚康司, 山崎直也

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 ( 日本皮膚悪性腫瘍学会 ) 31回 149 - 149 2015年07月

日本人の悪性黒色腫のBRAF、NRAS、KIT変異率と臨床所見

境澤香里, 芦田敦子, 伊東孝通, 藤澤康弘, 緒方大, 松下茂人, 藤井一恭, 福島聡, 柴山慶継, 八田尚人, 竹之内辰也, 上原治朗, 奥山隆平, 山崎直也, 宇原久

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 125 ( 4 ) 940 - 940 2015年04月

これからのがん免疫療法と今後の展望

清原祥夫, 山崎直也, 宇原久, 福島聡, 山口研成, 室圭, 山本信之, 里内美弥子, 瀬戸貴司, 井上彰, 後藤功一, 鵜殿平一郎, 西川博嘉, 山中竹春

Immuno-Oncology Frontier ( (株)メディカルレビュー社 ) 1 ( 1 ) 14 - 21 2015年01月

Alteration of dermoscopic features in a juvenile xanthogranuloma during follow-up of 43 months

Toshinori Unno, Akane Minagawa, Hiroshi Koga, Hisashi Uhara, Ryuhei Okuyama

International Journal of Dermatology ( Blackwell Publishing Ltd ) 53 ( 12 ) e590 - e591 2014年12月

速報，短報，研究ノート等（学術雑誌）

抗CTLA-4抗体を用いたメラノーマの治療 (特集免疫療法の逆襲を現実化した免疫checkpointの修飾)

宇原久, 奥山隆平

腫瘍内科 = Clinical oncology ( 科学評論社 ) 14 ( 5 ) 427 - 433 2014年11月

Unilateral pigmented purpuric dermatosis associated with deep thrombosis

Yasutomo Mikoshiba, Hisashi Uhara, Ryuhei Okuyama, Minoru Saiki

International Journal of Dermatology 53 ( 2 ) e87 - e88 2014年02月

速報，短報，研究ノート等（学術雑誌）

Successful treatment of rheumatoid vasculitis-associated skin ulcer with a TNF-α antagonist

Atsuko Ashida, Hiroshi Murata, Yasutomo Mikoshiba, Atsuko Ohashi, Aya Kobayashi, Hiroshi Koga, Hisashi Uhara, Ryuhei Okuyama

International Journal of Dermatology 53 ( 2 ) e154 - e156 2014年02月

速報，短報，研究ノート等（学術雑誌）

5-Hydroxymethylcytosine as a useful marker to differentiate between malignant melanomas and benign melanocytic nevi

Ryuhei Uchiyama, Hisashi Uhara, Aya Uchiyama, Eisaku Ogawa, Yuko Takazawa, Atsuko Ashida, Hiroshi Koga, Koichi Hayashi, Yukiko Kiniwa, Ryuhei Okuyama

JOURNAL OF DERMATOLOGICAL SCIENCE ( ELSEVIER IRELAND LTD ) 73 ( 2 ) 161 - 163 2014年02月

速報，短報，研究ノート等（学術雑誌）

Marked histiocytic infiltration in neonatal lupus erythematosus

Nagisa Okada, Ryuhei Okuyama, Hisashi Uhara

Journal of Dermatology 41 ( 2 ) 192 - 193 2014年02月

速報，短報，研究ノート等（学術雑誌）

Fibrosarcomatous variant of dermatofibrosarcoma protuberans with pancreatic metastasis

Hiroshi Murata, Atsuko Ohashi, Atsuko Ashida, Hisashi Uhara, Ryuhei Okuyama, Takenari Nakata, Kunihiko Shingu

International Journal of Dermatology 53 ( 2 ) e140 - e142 2014年02月

速報，短報，研究ノート等（学術雑誌）

Usefulness of high-frequency sonography for the diagnosis of asymptomatic myopathy in Löfgren's syndrome

Atsuko Ohashi, Hiroshi Koga, Koichi Hayashi, Hisashi Uhara, Ryuhei Okuyama

International Journal of Dermatology 53 ( 1 ) e62 - e63 2014年01月

速報，短報，研究ノート等（学術雑誌）

Generalized pustulosis associated with disseminated Mycobacterium avium infection in a non-AIDS patient

Yuko Asai, Yukiko Kiniwa, Nagisa Okada, Toshimasa Futatsugi, Atsuhito Ushiki, Hisashi Uhara, Ryuhei Okuyama

European Journal of Dermatology ( John Libbey Eurotext ) 24 ( 3 ) 402 - 403 2014年

速報，短報，研究ノート等（学術雑誌）

Detection of the tumor margin of basal-cell carcinoma using dermoscopy and high-frequency ultrasound with narrow pieces of surgical tape as skin markers

Koichi Hayashi, Hisashi Uhara, Ryuhei Okuyama

Dermatologic Surgery ( Lippincott Williams and Wilkins ) 40 ( 6 ) 704 - 706 2014年

速報，短報，研究ノート等（学術雑誌）

Combination chemotherapy of carboplatin and paclitaxel for metastatic melanoma

Yuki Sato, Hisashi Uhara, Atsuko Ashida, Ryuhei Okuyama

Journal of Dermatology 40 ( 12 ) 1050 - 1051 2013年12月

速報，短報，研究ノート等（学術雑誌）

Bullous formation in a patient with familial amyloid polyneuropathy type I

Aya Kobayashi, Hisashi Uhara, Kenji Kido, Yoshiki Sekijima, Kana Tojo, Shu-ichi Ikeda, Ryuhei Okuyama

International Journal of Dermatology 52 ( 11 ) 1398 - 1400 2013年11月

速報，短報，研究ノート等（学術雑誌）

Lamellar ichthyosis in a collodion baby caused by CYP4F22 mutations in a non-consanguineous family outside the Mediterranean

Kazumitsu Sugiura, Takuya Takeichi, Kana Tanahashi, Yasutomo Ito, Tomoki Kosho, Ken Saida, Hisashi Uhara, Ryuhei Okuyama, Masashi Akiyama

Journal of Dermatological Science 72 ( 2 ) 193 - 195 2013年11月

速報，短報，研究ノート等（学術雑誌）

S-1 induced a durable response in metastatic extramammary Paget's disease

Yasutomo Mikoshiba, Hisashi Uhara, Hitomi Kubo, Ryuhei Okuyama

Journal of Dermatology 40 ( 8 ) 664 - 665 2013年08月

速報，短報，研究ノート等（学術雑誌）

Age-related prevalence of dermoscopic patterns in acquired melanocytic nevus on acral volar skin

Akane Minagawa, Hiroshi Koga, Hisashi Uhara, Yoshiharu Yokokawa, Ryuhei Okuyama

JAMA Dermatology 149 ( 8 ) 989 - 990 2013年08月

速報，短報，研究ノート等（学術雑誌）

Effectiveness of topical maxacalcitol for acquired perforating disorder

Hiroyuki Yoshiya, Ryuhei Okuyama, Hisashi Uhara

Journal of the American Academy of Dermatology 68 ( 6 ) e181 - e182 2013年06月

速報，短報，研究ノート等（学術雑誌）

A regulation of keratinocyte differentiation and proliferation by transcription factors Runx1 and Runx3

R. Uchiyama, E. Ogawa, Y. Kiniwa, H. Uhara, W. F. Wong, K. Kofu, S. Ikawa, M. Satake, R. Okuyama

JOURNAL OF INVESTIGATIVE DERMATOLOGY ( NATURE PUBLISHING GROUP ) 133 S105 - S105 2013年05月

研究発表ペーパー・要旨（国際会議）

E-FABP is a predictive marker of clinical response to systemic treatment and ultraviolet therapy in psoriatic skin lesions

E. Ogawa, T. Miyake, A. Mikoshiba, A. Kobayashi, H. Uhara, R. Okuyama

JOURNAL OF INVESTIGATIVE DERMATOLOGY ( NATURE PUBLISHING GROUP ) 133 S166 - S166 2013年05月

研究発表ペーパー・要旨（国際会議）

Narrow-band UVB 療法が有効であった慢性苔癬状粃糠疹の女児例

吉川美香, 木庭幸子, 古賀弘志, 宇原久, 奥山隆平

日本小児皮膚科学会雑誌 = Journal of pediatric dermatology 32 ( 1 ) 45 - 48 2013年02月

Case of a cutaneous angiomyolipoma in the ear

Yasutomo Mikoshiba, Hiroshi Murata, Atsuko Ashida, Nana Saito, Hiroshi Koga, Hisashi Uhara, Ryuhei Okuyama

Journal of Dermatology 39 ( 9 ) 808 - 809 2012年09月

速報，短報，研究ノート等（学術雑誌）

Assessment of BRAF and KIT mutations in Japanese melanoma patients

Atsuko Ashida, Hisashi Uhara, Yukiko Kiniwa, Misae Oguchi, Hiroshi Murata, Yasufumi Goto, Aya Uchiyama, Eisaku Ogawa, Koichi Hayashi, Hiroshi Koga, Ryuhei Okuyama

Journal of Dermatological Science 66 ( 3 ) 240 - 242 2012年06月

速報，短報，研究ノート等（学術雑誌）

A case of mycobacterial skin disease caused by mycobacterium peregrinum, and a review of cutaneous infection

Fuminao Kamijo, Hisashi Uhara, Hitomi Kubo, Kazue Nakanaga, Yoshihiko Hoshino, Norihisa Ishii, Ryuhei Okuyama

Case Reports in Dermatology 4 ( 1 ) 76 - 79 2012年01月

書評論文，書評，文献紹介等

An 83-year-old Japanese man presented with a 2-month history of symptomatic nodules on the left hand. He was not in an immunocompromised condition and reported no causal events. A biopsy specimen demonstrated granulomatous tissue with mixed cell infiltration consisting of neutrophils, histiocytes, lymphocytes, and multinuclear giant cells. No bacillus was detected by PAS, acid-fast stain, immunofluorescent stain or polymerase chain reaction analysis. The isolate was found to be a rapidly growing mycobacterium after 4 weeks of incubation at 25°C on an Ogawa egg slant. Mycobacterium peregrinum was isolatedby DNA-DNA hybridization analysis, 16S rRNA gene sequence, and by its production of 3-day arylsulfatase. The patient received 200 mg oral minocycline for 28 weeks. The lesion disappeared after 10 weeks of this treatment. Copyright © 2012 S. Karger AG, Basel.

Rapid progression of Hidradenitis suppurativa in the lower leg of a patient with psoriasis vulgaris

Asuka Tanaka, Yasufumi Goto, Maiko Iwade, Hisashi Uhara, Ryuhei Okuyama

Acta Dermato-Venereologica 92 ( 1 ) 105 - 106 2012年01月

速報，短報，研究ノート等（学術雑誌）

Sweat test with water-erasable ink

Hisashi Uhara, Kenta Nakamura, Yasutomo Mikoshiba, Tomomi Miyake, Ryuhei Okuyama

Acta Dermato-Venereologica 92 ( 4 ) 432 - 433 2012年

速報，短報，研究ノート等（学術雑誌）

Response to a comment on rapid progression of hidradenitis suppurativa in the lower leg of a patient with psoriasis vulgaris

Hisashi Uhara, Ryuhei Okuyama

Acta Dermato-Venereologica 92 ( 4 ) 447 2012年

速報，短報，研究ノート等（学術雑誌）

Open pores with plugs in porokeratosis clearly visualized with the dermoscopic furrow ink test: Report of 3 cases

Hisashi Uhara, Fuminao Kamijo, Ryuhei Okuyama, Toshiaki Saida

Archives of Dermatology ( American Medical Association ) 147 ( 7 ) 866 - 868 2011年

速報，短報，研究ノート等（学術雑誌）

Leg ulcers associated with positive lupus anticoagulant in two cases of klinefelter's syndrome

Yasufumi Goto, Hisashi Uhara, Hiroshi Murata, Hiroshi Koga, Tomoki Kosho, Masahide Yamazaki, Minoru Takata, Ryuhei Okuyama

Acta Dermato-Venereologica 91 ( 1 ) 90 - 91 2011年

速報，短報，研究ノート等（学術雑誌）

Calciphylaxis in poems syndrome: A case treated with etidronate

Mika Yoshikawa, Hisashi Uhara, Fuyuko Arakura, Hiroshi Murata, Hitomi Kubo, Minoru Takata, Kunihiro Yoshida, R. Okuyama

Acta Dermato-Venereologica 91 ( 1 ) 98 - 99 2011年

速報，短報，研究ノート等（学術雑誌）

Takayasu's arteritis with pyoderma gangrenosum and necrotizing vasculitis

A. Minagawa, H. Uhara, T. Saida

Clinical and Experimental Dermatology 35 ( 3 ) 329 - 330 2010年04月

速報，短報，研究ノート等（学術雑誌）

Sentinel lymph node biopsy in Japan

Hisashi Uhara, Minoru Takata, Toshiaki Saida

International Journal of Clinical Oncology 14 ( 6 ) 490 - 496 2009年12月

書評論文，書評，文献紹介等

Similar to the practice in Western countries, intraoperative lymphatic mapping and selected lymphadenectomy (SLNB) have been validated and are widely performed for the staging of melanoma in Japan. Recent studies have shown that approximately 90% (73/81) of university hospitals and several cancer hospitals routinely perform SLNB, and half of all melanoma patients receive this examination. SLNB is performed according to a variation of the standard procedure described by Morton and Cochran. The most frequently used tracers are Tc99m-tin colloid or Tc99m-phytate for scintigraphy and patent blue violet or indigo carmine as a blue dye. Some institutions use indocyanine green, which is fluorescent and can be used to visualize sentinel lymph node(s) (SLNs) under an infrared camera. The recent detection rate of SLNs has increased to more than 95% with the method using blue dye, lymphoscintigraphy, and a handheld gamma probe. In a multicenter study, the rates of metastasis in SLN were as follows: pTis, 0% (0/36) pT1, 10.7% (6/56) pT2, 21.0% (13/63) pT3, 34.0% (35/103) and pT4, 62.4% (63/101). The metastasis rate was also significantly related to ulceration of the primary tumor. Here, we discuss data from Japanese patients and the present status of SLNB in Japan. © 2009 Japan Society of Clinical Oncology.

The whiteboard marker as a useful tool for the dermoscopic "furrow ink test"

Hisashi Uhara, Hiroshi Koga, Minoru Takata, Toshiaki Saida

Archives of Dermatology 145 ( 11 ) 1331 - 1332 2009年11月

速報，短報，研究ノート等（学術雑誌）

Herpes zoster histopathologically mimicking CD30-positive anaplastic large cell lymphoma

J. Shiohara, H. Koga, H. Uhara, M. Takata, T. Saida, T. Uehara

Journal of the European Academy of Dermatology and Venereology 23 ( 5 ) 618 - 619 2009年05月

速報，短報，研究ノート等（学術雑誌）

濾胞性リンパ腫に伴った腫瘍随伴性天疱瘡の1例

光楽文生, 鶴田恭子, 内山龍平, 井出葉子, 皆川茜, 古賀弘志, 木庭幸子, 村田浩, 宇原久, 斎田俊明, 伊藤俊朗, 野網淑子

日本皮膚科学会雑誌 ( (公社)日本皮膚科学会 ) 118 ( 10 ) 2018 - 2018 2008年09月

Systemic plasmacytosis with aseptic bone necrosis and high fever [3]

Masao Fukuzawa, Maki Yamaura, Hisashi Uhara, Toshiaki Saida

Journal of Dermatology ( Japanese Dermatological Association ) 31 ( 8 ) 696 - 698 2004年

速報，短報，研究ノート等（学術雑誌）

Urticaria and anaphylaxis due to sting by an ant (Brachyponera chinensis) [2]

M. Fukuzawa, F. Arakura, Y. Yamazaki, H. Uhara, T. Saida

Acta Dermato-Venereologica 82 ( 1 ) 59 2002年

速報，短報，研究ノート等（学術雑誌）

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