論文 - 松浦　基樹

Fatty Acid Metabolism Regulators Have Pivotal Roles in the Pathogenesis of Ovarian Carcinoma

Megumi Watanabe, Motoki Matsuura, Tatsuya Sato, Makoto Usami, Tsuyoshi Saito, Masato Furuhashi, Kohichi Takada, Hiroshi Ohguro

International Journal of Molecular Sciences    2025年05月

DOI

Risk-reducing salpingo-oophorectomy for hereditary breast and ovarian cancer patients with vaginal natural orifice transluminal endoscopic surgery (vNOTES)

Masato Tamate, Motoki Matsuura, Sachiko Nagao, Shoko Kurokawa, Taishi Akimoto, Tsuyoshi Saito

International Journal of Gynecological Cancer    2025年04月

DOI

【エネルギーデバイス アラカルト-知っておきたい使い方の留意点と技術革新】総論 モードの特性と使い分け

玉手 雅人, 松浦 基樹, 齋藤 豪

臨床婦人科産科 ( (株)医学書院 )  78 ( 12 ) 1083 - 1090  2024年12月

　概要を見る

＜文献概要＞●電気メスのモードと本体の使い分け:電気メスの効果と性能は,モードと出力設定で変化するが,電気メスを接続する本体の種類によっても異なる.●他の手術機器との使い分け,バイポーラ・アドバンスドバイポーラ・バイクランプの使い分け:電気メス,バイポーラ,アドバンスドバイポーラ,超音波凝固切開装置の組み合わせは術式・手技・コストで考慮する.●機械の特性を理解して,術者が自身の技量や手術スタイルに合わせてエネルギーデバイスを扱うことが重要と思われる.

【エネルギーデバイス アラカルト-知っておきたい使い方の留意点と技術革新】各種デバイスの原理・有用性と使用上の注意点 シーリングデバイス

松浦 基樹, 玉手 雅人, 齋藤 豪

臨床婦人科産科 ( (株)医学書院 )  78 ( 12 ) 1104 - 1111  2024年12月

　概要を見る

＜文献概要＞●シーリングデバイスは直径7mmまでの血管や組織束がシール可能であり,超音波凝固切開装置より太い血管をシールすることができる.●シーリングデバイスは高周波エネルギーを瞬時に供給して血管のシールを行うため,手術効率が向上するだけではなく,熱の拡散を極力抑えることで周囲の組織への影響を最小限に抑えることができる.●外科医は各デバイスの原理や有用性・注意点などを習熟したうえで,これらのデバイスを使用するべきである.

Successful Outcome of Stage IB3 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Vaginal Radical Trachelectomy: A Case Report.

Masato Tamate, Motoki Matsuura, Masayuki Someya, Tasuku Mariya, Shinichi Ishioka, Tsuyoshi Saito

Cureus   16 ( 10 ) e71626  2024年10月  [国際誌]

　概要を見る

Vaginal trachelectomy, which involves resecting the cervix and its parametrium, is a fertility-sparing option for the treatment of early-stage cervical cancer. Although no consensus has been reached on whether simple or radical trachelectomy is preferable, the vaginal approach is typically avoided for tumors larger than 2 cm due to concerns about recurrence. However, some evidence suggests that fertility preservation may still be viable for select patients with larger tumors. This case report describes a woman with bulky cervical cancer who wished to preserve her fertility. After undergoing neoadjuvant chemotherapy (NAC) and vaginal radical trachelectomy (VRT), she achieved a favorable oncological and perinatal outcome, successfully giving birth to a near-full-term baby. The report outlines the patient's management before, during, and after the procedure, including perinatal care. While careful selection of candidates is crucial, accumulating case reports and future trials are expected to shed more light on this treatment approach.

DOI PubMed

Human papillomavirus self‐sampling and urine‐sampling tests and the management and short‐term outcomes of cervical intraepithelial neoplasia: A prospective observational study

Motoki Matsuura, Masato Tamate, Sachiko Nagao, Taishi Akimoto, Fukiko Kasuga, Kimihito Saito, Satoshi Shikanai, Yoko Nishimura, Mizue Teramoto, Tsuyoshi Saito

Journal of Obstetrics and Gynaecology Research    2024年10月

DOI

Niraparib in Japanese patients with heavily pretreated, homologous recombination-deficient ovarian cancer: final results of a multicenter phase 2 study.

Daisuke Aoki, Tsutomu Tabata, Satoshi Yanagida, Toshiaki Nakamura, Eiji Kondo, Junzo Hamanishi, Kenichi Harano, Kosei Hasegawa, Takeshi Hirasawa, Kensuke Hori, Shinichi Komiyama, Motoki Matsuura, Hidekatsu Nakai, Hiroko Nakamura, Jun Sakata, Kazuhiro Takehara, Munetaka Takekuma, Yoshihito Yokoyama, Yoichi Kase, Shuuji Sumino, Junpei Soeda, Ai Kato, Ajit Suri, Aikou Okamoto, Toru Sugiyama

Journal of gynecologic oncology   35 ( 5 ) e114  2024年09月  [国際誌]

　概要を見る

OBJECTIVE: To evaluate the long-term efficacy and safety of niraparib in Japanese women with heavily pretreated ovarian cancer. METHODS: This was the follow-up analysis of a phase 2, multicenter, open-label, single-arm study in Japanese women with homologous recombination-deficient, platinum-sensitive, relapsed, high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who had completed 3-4 lines of chemotherapy and were poly(ADP-ribose) polymerase inhibitor naïve. Participants received niraparib (starting dose, 300 mg) once daily in continuous 28-day cycles until objective disease progression, unacceptable toxicity, or consent withdrawal. The primary endpoint was confirmed objective response rate (ORR), as assessed using Response Evaluation Criteria in Solid Tumors version 1.1. Safety evaluations included treatment-emergent adverse events (TEAEs). RESULTS: 20 patients were enrolled in the study and included in both efficacy and safety analyses. Median total study duration was 759.5 days. Median dose intensity was 201.3 mg/day. Confirmed ORR was 60.0% (90% confidence interval [CI]=39.4-78.3); 2 patients had complete response and 10 patients had partial response. Median duration of response was 9.9 months (95% CI=3.9-26.9) and the disease control rate was 90.0% (95% CI=68.3-98.8). The most common TEAEs were anemia (n=15), nausea (n=12), and decreased platelet count (n=11). TEAEs leading to study drug dose reduction, interruption, or discontinuation were reported in 16 (80.0%), 15 (75.0%), and 2 patients (10.0%), respectively. CONCLUSION: The long-term efficacy and safety profile of niraparib was consistent with previous findings in the equivalent population in non-Japanese patients. No new safety signals were identified. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03759600.

DOI PubMed

IB3期の子宮頸癌に対して術前化学療法後に広汎子宮頸部摘出術を施行し分娩となった1例

佐藤 冴子, 染谷 真行, 玉手 雅人, 松浦 基樹, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  71回   48 - 48  2024年09月

ロボット支援子宮全摘出術での発光式尿管カテーテルと子宮トランスイルミネーターの使用経験

幅田 周太朗, 黒川 晶子, 有元 千紘, 長尾 沙智子, 玉手 雅人, 秋元 太志, 松浦 基樹, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  71回   78 - 78  2024年09月

当院における類内膜癌G3症例の細胞診・病理形態学的評価と臨床経過の検討

幅田 周太朗, 齋藤 晋平, 有元 千紘, 野藤 五沙, 長尾 沙智子, 黒川 晶子, 玉手 雅人, 真里谷 奨, 秋元 太志, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  66回   327 - 327  2024年07月

Analysis of Treatment Response With Proteins Related to Tumor Immunity in Postoperative Irradiated Cervical Cancer Patients.

Shoh Mafune, Masanori Someya, Tomokazu Hasegawa, Takaaki Tsuchiya, Mio Kitagawa, Toshio Gocho, Ryu Okuda, Masahiro Iwasaki, Motoki Matsuura, Terufumi Kubo, Yoshihiko Hirohashi, Toshihiko Torigoe, Tsuyoshi Saito, Koh-Ichi Sakata

Anticancer research   44 ( 7 ) 3077 - 3086  2024年07月  [国際誌]

　概要を見る

BACKGROUND/AIM: This study evaluated the association between programmed cell death-ligand 1 (PD-L1) and prognosis in patients with cervical cancer treated with postoperative radiation and the impact of neoadjuvant chemotherapy (NAC) on this association. PATIENTS AND METHODS: Immunohistochemical analysis was performed on biopsy specimens from 42 patients who did not receive NAC and from paired samples before (biopsies) and after (resected tissues) chemotherapy from 46 patients who received NAC to determine the association of PD-L1 with radiotherapy outcomes. RESULTS: In the non-NAC group, patients with ≥10% PD-L1-expressing tumor cells prior to treatment had better recurrence-free survival (RFS) than those with <10% PD-L1-expressing tumor cells (p=0.001). In the NAC group, RFS was significantly lower (p=0.005) in the group with a ≥5% reduction of PD-L1 expression in tumor cells after chemotherapy than in those with <5% reduction. In multivariate analysis, only PD-L1 expression (non-NAC group) and the change in PD-L1 expression (NAC group) were associated with RFS. CONCLUSION: Low PD-L1 expression in a cervical tumor prior to treatment was identified as a risk factor for a poor outcome after postoperative radiotherapy. Furthermore, NAC induces an immunological shift that reduces PD-L1 levels in tumor cells, thereby negatively impacting treatment outcomes.

DOI PubMed

当院における類内膜癌G3症例の細胞診・病理形態学的評価と臨床経過の検討

幅田 周太朗, 齋藤 晋平, 有元 千紘, 野藤 五沙, 長尾 沙智子, 黒川 晶子, 玉手 雅人, 真里谷 奨, 秋元 太志, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  66回   327 - 327  2024年07月

当院における再発子宮体癌に対するPembrolizumab+Lenvatinibの使用経験

長尾 沙智子, 松浦 基樹, 黒川 晶子, 玉手 雅人, 秋元 太志, 幅田 周太朗, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  66回   405 - 405  2024年07月

The roles of tight junction protein cingulin in human endometrioid endometrial cancer.

Arisa Kura, Kimihito Saito, Takumi Konno, Takayuki Kohno, Hiroshi Shimada, Tadahi Okada, Soshi Nishida, Daichi Ishii, Motoki Matsuura, Tsuyoshi Saito, Takashi Kojima

Tissue barriers     2361976 - 2361976  2024年06月  [国際誌]

　概要を見る

The bicellular tight junction molecule cingulin (CGN) binds to microtubules in centrosomes. Furthermore, CGN contributes to the tricellular tight junction (tTJ) proteins lipolysis-stimulated lipoprotein receptor (LSR) and tricellulin (TRIC). CGN as well as LSR decreased during the malignancy of endometrioid endometrial cancer (EEC). Although tTJ protein LSR is involved in the malignancy of some cancers, including EEC, the role of CGN is unknown. In this study, we investigated the roles of CGN with tTJ proteins in human EEC cells by using the CGN-overexpressing EEC cell line Sawano. In 2D cultures, CGN was colocalized with LSR and TRIC at tTJ or at γ-tubulin-positive centrosomes. In immunoprecipitation with CGN antibodies, CGN directly bound to LSR, TRIC, and β-tubulin. Knockdown of CGN by the siRNA decreased the epithelial barrier and enhanced cell proliferation, migration and invasion, as well as knockdown of LSR. In the Sawano cells cocultured with normal human endometrial stromal cells, knockdown of CGN decreased expression of LSR and TRIC via MAPK and AMPK pathways. In 2.5D cultures, knockdown of CGN induced the formation of abnormal cysts and increased the permeability of FD-4 to the lumen. In 2D and 2.5D cultures, treatment with β-estradiol with or without EGF or TGF-β decreased CGN expression and the epithelial permeability barrier and enhanced cell migration, and pretreatment with EW7197+AG1478, U0126 or an anti-IL-6 antibody prevented this. In conclusion, CGN, with tTJ proteins might suppress the malignancy of human EEC and its complex proteins are sensitive to estrogen and growth factors derived from stromal cells.

DOI PubMed

vNOTESの可能性を広げる術式の研究

玉手 雅人, 松浦 基樹, 長尾 沙智子, 黒川 晶子, 諸井 明仁, 秋元 太志, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 35 ) 143 - 143  2024年06月

hinotoriを用いた婦人科ロボット支援手術

長尾 沙智子, 松浦 基樹, 黒川 晶子, 玉手 雅人, 秋元 太志, 諸井 明仁, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 35 ) 150 - 150  2024年06月

日本におけるCSTの現状,産婦人科CSTにおける役割

玉手 雅人, 松浦 基樹, 長尾 沙智子, 黒川 晶子, 秋元 太志, 幅田 周太朗, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 35 ) 121 - 121  2024年06月

日本におけるCSTの現状,産婦人科CSTにおける役割

玉手 雅人, 松浦 基樹, 長尾 沙智子, 黒川 晶子, 秋元 太志, 幅田 周太朗, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 35 ) 121 - 121  2024年06月

vNOTESを導入する際の諸問題 vNOTES,船頭多くして船海に出るために

玉手 雅人, 松浦 基樹, 長尾 沙智子, 黒川 晶子, 諸井 明仁, 秋元 太志, 幅田 周太朗, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 35 ) 137 - 137  2024年06月

vNOTESの可能性を広げる術式の研究

玉手 雅人, 松浦 基樹, 長尾 沙智子, 黒川 晶子, 諸井 明仁, 秋元 太志, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 35 ) 143 - 143  2024年06月

hinotoriを用いた婦人科ロボット支援手術

長尾 沙智子, 松浦 基樹, 黒川 晶子, 玉手 雅人, 秋元 太志, 諸井 明仁, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 35 ) 150 - 150  2024年06月

vNOTESを導入する際の諸問題 vNOTES,船頭多くして船海に出るために

玉手 雅人, 松浦 基樹, 長尾 沙智子, 黒川 晶子, 諸井 明仁, 秋元 太志, 幅田 周太朗, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 35 ) 137 - 137  2024年06月

Early outcomes of three new robotic surgical systems in patients undergoing hysterectomy.

Motoki Matsuura, Sachiko Nagao, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Tsuyoshi Saito

Updates in surgery    2024年05月  [国際誌]

　概要を見る

New robot models, such as hinotori™, da Vinci SP™, and Hugo™, have been introduced in Japan. This study examined the surgical outcomes of these models in patients from the initial stages of their introduction to the present day.We retrospectively reviewed 36 patients with endometrial cancer or benign gynecologic disease, who underwent robotic hysterectomy using da Vinci SP™, hinotori™, or Hugo™ between March 2023 and March 2024.Robotic hysterectomy was performed using hinotori™ in 10 patients, da Vinci SP™ in 16 patients, and Hugo™ in 10 patients. No significant differences were observed in the characteristics of the patients subjected to surgery using these models. The total operative time was 123.0 min (93-144 min) for hinotori™, 95.0 min (79-165 min) for da Vinci SP™, and 98.5 min (74-177 min) for Hugo™. The total operative time of hinotori™ was significantly longer than that of the other two models (p = 0.031). No differences were observed among the robot systems with respect to complications during or after surgery and the intensity of postoperative pain.Differences in the surgical time were noted depending on the model used. It has been proven that surgeons who are already proficient in performing robotic surgery with da Vinci Xi™ can safely perform surgeries with the new models.

DOI PubMed

Surgical Outcomes of da Vinci Xi™ and da Vinci SP™ for Early-Stage Endometrial Cancer in Patients Undergoing Hysterectomy.

Motoki Matsuura, Sachiko Nagao, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Tsuyoshi Saito

Journal of clinical medicine   13 ( 10 )  2024年05月  [国際誌]

　概要を見る

Objectives: This study aimed to evaluate and compare the feasibility and outcomes of two robotic hysterectomy (da Vinci Xi™ vs. da Vinci SP™) systems without lymph node dissection in patients with early-stage endometrial cancer, and assess the postoperative recurrence rate and overall survival of patients. Methods: A retrospective review of 84 patients who underwent robotic hysterectomy for endometrial cancer (stage 1A) was conducted. Surgical procedures, patient characteristics, intraoperative measures, and postoperative outcomes were statistically analyzed. A single gynecologist performed all surgeries. Results: Patient characteristics, average age, and body mass index showed no significant differences between the two models. The total operative time was significantly shorter with da Vinci SP™. Recurrence was identified in only one patient operated on with da Vinci Xi™. All patients were alive during analysis, with a median overall survival of 38 and 9 months for da Vinci Xi™ and da Vinci SP™, respectively. Conclusions: Robotic hysterectomy without lymph node dissection appears to be a safe and effective approach for patients with early-stage endometrial cancer. The da Vinci SP offers the advantage of shorter operative times than the da Vinci Xi™. These findings support the consideration of robotic surgery as a viable option for selected patients.

DOI PubMed

Prediction of Mismatch Repair Status in Endometrial Cancer from Histological Slide Images Using Various Deep Learning-Based Algorithms.

Mina Umemoto, Tasuku Mariya, Yuta Nambu, Mai Nagata, Toshihiro Horimai, Shintaro Sugita, Takayuki Kanaseki, Yuka Takenaka, Shota Shinkai, Motoki Matsuura, Masahiro Iwasaki, Yoshihiko Hirohashi, Tadashi Hasegawa, Toshihiko Torigoe, Yuichi Fujino, Tsuyoshi Saito

Cancers   16 ( 10 )  2024年05月  [国際誌]

　概要を見る

The application of deep learning algorithms to predict the molecular profiles of various cancers from digital images of hematoxylin and eosin (H&E)-stained slides has been reported in recent years, mainly for gastric and colon cancers. In this study, we investigated the potential use of H&E-stained endometrial cancer slide images to predict the associated mismatch repair (MMR) status. H&E-stained slide images were collected from 127 cases of the primary lesion of endometrial cancer. After digitization using a Nanozoomer virtual slide scanner (Hamamatsu Photonics), we segmented the scanned images into 5397 tiles of 512 × 512 pixels. The MMR proteins (PMS2, MSH6) were immunohistochemically stained, classified into MMR proficient/deficient, and annotated for each case and tile. We trained several neural networks, including convolutional and attention-based networks, using tiles annotated with the MMR status. Among the tested networks, ResNet50 exhibited the highest area under the receiver operating characteristic curve (AUROC) of 0.91 for predicting the MMR status. The constructed prediction algorithm may be applicable to other molecular profiles and useful for pre-screening before implementing other, more costly genetic profiling tests.

DOI PubMed

我々はこうしている～子宮頸癌手術におけるMISの工夫 我々が行う子宮頸癌に対する腹腔鏡下広汎子宮全摘術の工夫

松浦 基樹, 長尾 沙智子, 黒川 晶子, 玉手 雅人, 秋元 太志, 幅田 周太朗, 齋藤 豪

日本婦人科腫瘍学会雑誌 ( (公社)日本婦人科腫瘍学会 )  42 ( 2 ) 114 - 117  2024年04月

子宮移植までのマイルストーン

玉手 雅人, 馬場 剛, 和田 渚, 古来 愛香, 幅田 周太朗, 小川 万梨絵, 松浦 基樹, 齋藤 豪

日本生殖医学会雑誌 ( (一社)日本生殖医学会 )  69 ( 1-2 ) 122 - 122  2024年04月

自己採取および尿採取法による腟内HPV検査の患者の受け入れに関する検討

齋藤 豪, 松浦 基樹, 寺田 倫子, 玉手 雅人, 高田 優子, 西村 庸子, 山下 真祐子, 諸井 明仁

日本女性医学学会雑誌 ( (一社)日本女性医学学会 )  31 ( 3 ) 404 - 409  2024年04月

　概要を見る

子宮頸がん検診の受診率向上は喫緊の課題である.自己採取または尿採取腟内HPV検査は複数の介入研究で受診率向上に有効と報告されている.医師採取HPV検査と同等の感度があれば,受診率向上が課題であるわが国において有効な手段となりうる.われわれはこれまで自己採取・尿採取HPV検査の有効性について比較検討研究を行い報告してきたが,本研究ではよりよい自己採取法を目指し,検体採取対象者に対し検査の受け入れに関するアンケート調査を行った.年齢は20～50歳とし,CIN2以上の患者を100名以上含む計300名を対象に研究を行った.アンケート300人中281人が回答し,子宮頸がんについては「知っている」,あるいは,「なんとなく知っている」と答えた人が93.1%,頸がんが検診でがんになる前の段階で見つけることを「知っている」と答えた人は87.9%,頸がんの原因がHPVと言うウイルスの感染であることを「知っている」と答えた人の割合は93.3%といずれも高い割合であった.採取前に38.6%が不安ありと答えたが,すべての患者が採取を完遂し患者にとって受け入れられているものと考えた.頸がんに対する認知度は高いものの検診率の増加に結びついていないことが今後の課題であり,自己採取HPV検査も解決策の一つと考えられた.(著者抄録)

The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line.

Takumi Konno, Takayuki Kohno, Shin Kikuchi, Arisa Kura, Kimihito Saito, Tadahi Okada, Hiroshi Shimada, Yuya Yamazaki, Tomoki Sugiyama, Motoki Matsuura, Yuki Ohsaki, Tsuyoshi Saito, Takashi Kojima

Tissue barriers     2304443 - 2304443  2024年01月  [国際誌]

　概要を見る

It is known that there are abnormalities of tight junction functions, cell migration and mitochondrial metabolism in human endometriosis and endometrial carcinoma. In this study, we investigated the effects of growth factors and their inhibitors on the epithelial permeability barrier, cell migration and mitochondrial metabolism in 2D and 2.5D cultures of human endometrioid endometrial carcinoma Sawano cells. We also investigated the changes of bicellular and tricellular tight junction molecules and ciliogenesis induced by these inhibitors. The growth factors TGF-β and EGF affected the epithelial permeability barrier, cell migration and expression of bicellular and tricellular tight junction molecules in 2D and 2.5D cultures of Sawano cells. EW-7197 (a TGF-β receptor inhibitor), AG1478 (an EGFR inhibitor) and SP600125 (a JNK inhibitor) affected the epithelial permeability barrier, cell migration and mitochondrial metabolism and prevented the changes induced by TGF-β and EGF in 2D and 2.5D cultures. EW-7197 and AG1478 induced ciliogenesis in 2.5D cultures. In conclusion, TGF-β and EGF promoted the malignancy of endometrial cancer via interplay among the epithelial permeability barrier, cell migration and mitochondrial metabolism. EW-7197 and AG1478 may be useful as novel therapeutic treatments options for endometrial cancer.

DOI PubMed

Step-by-step demonstration of “sciatic-nerve-preserved beyond-LEER” in a Thiel-embalmed cadaver: a novel salvage surgery for recurrent gynecologic malignancies

Hiroyuki Kanao, Masato Tamate, Motoki Matsuura, Sachiko Nagao, Miseon Nakazawa, Shutaro Habata, Tsuyoshi Saito

Journal of Gynecologic Oncology    2024年

DOI

A Rare Case of Small Intestinal Cancer With Uterine Metastasis After Surgery for Ovarian Metastasis, Diagnosed Using Immunostaining.

Sachiko Nagao, Motoki Matsuura, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Tsuyoshi Saito

Case reports in oncological medicine   2024   8551816 - 8551816  2024年  [国際誌]

　概要を見る

Uterine metastases from extragenital sites are rare. We present a case of a woman who had undergone surgery for small intestinal cancer and subsequently developed metastases in her left ovary and uterus. A nulliparous woman in her 50s underwent laparoscopic partial small bowel resection with lymph node dissection for small intestinal cancer. Five months later, computed tomography (CT) revealed a left ovarian tumor and ascites. She underwent bilateral adnexectomy and adjuvant chemotherapy, and the ovarian tumor was diagnosed as a small intestinal cancer metastasis. Two years after the small intestinal cancer surgery, a positron emission tomography (PET)-CT scan revealed a uterine accumulation. Cervical cytology was negative for intraepithelial lesion or malignancy. Endometrial histology showed an adenocarcinoma of the uterus. The patient underwent total abdominal hysterectomy followed by adjuvant chemotherapy. Histopathology and immunohistochemistry of the uterine tumor revealed that it was a metastasis of small intestinal cancer (Cytokeratin 7 [CK7] [-], Cytokeratin 20 [CK20] [+], Special AT-Rich Sequence-Binding Protein 2 [SATB2] [+], Paired Box Gene 2 [PAX2] [-], and estrogen receptor [ER] [-]). In patients with cancer, histopathology and immunohistochemistry are important for distinguishing between primary and metastatic tumors and for guiding the choice of treatment.

DOI PubMed

Niraparib in Japanese patients with platinum-sensitive recurrent ovarian cancer: final results of a multicenter phase 2 study

Hiroaki Itamochi, Nobuhiro Takeshima, Junzo Hamanishi, Kosei Hasegawa, Motoki Matsuura, Kiyonori Miura, Shoji Nagao, Hidekatsu Nakai, Naotake Tanaka, Hideki Tokunaga, Shin Nishio, Hidemichi Watari, Yoshihito Yokoyama, Yoichi Kase, Shuuji Sumino, Ai Kato, Ajit Suri, Toshiaki Yasuoka, Kazuhiro Takehara

Journal of Gynecologic Oncology    2024年

DOI

Diagnosis and Methods of Repair for a Uteroperitoneal Fistula (UPF) Formed After Gynecological Surgeries.

Nagisa Wada, Masato Tamate, Motoki Matsuura, Tsuyoshi Saito

Cureus   15 ( 12 ) e51064  2023年12月  [国際誌]

　概要を見る

A uteroperitoneal fistula (UPF) is a rare disorder that can lead to infertility and has never been reported. UPFs can cause infertility and perinatal complications. A 34-year-old woman (gravida 0) with a history of three gynecological surgeries using a uterine manipulator was diagnosed with a UPF using hysteroscopy and hysterosalpingography. She underwent laparoscopic uterine repair as an infertility treatment. The uterine perforation may have been caused by uterine manipulator insertion or suture failure in the myometrium during her previous laparoscopic myomectomy and cystectomy procedures. The UPF disappeared after the current surgical treatment. The complications of UPFs include infection, infertility, ectopic pregnancy, and uterine rupture. We expected that the presence of a fistula would increase the risk of impaired fertilization, implantation failure, and ectopic pregnancy. This case report contributes valuable insights into the diagnosis of UPFs and their laparoscopic repair.

DOI PubMed

内視鏡手術支援ロボット最新事情-開発者と使用者から見た理想と現実、問題点- da Vinci SPが切り拓く婦人科ロボット手術の近未来

松浦 基樹, 長尾 沙智子, 黒川 晶子, 玉手 雅人, 秋元 太志, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  28 ( 7 ) 981 - 981  2023年12月

分娩後の子宮全摘術時に発見され腹膜癌との鑑別が困難であった異所性脱落膜の1例

有元 千紘, 長尾 沙智子, 堀 清貴, 山崎 智子, 玉手 雅人, 高田 さくら, 松浦 基樹, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  67 ( 1 ) 11 - 15  2023年12月

　概要を見る

異所性脱落膜は,妊娠中の間葉系未分化細胞の化生もしくは子宮内膜症組織などにプロゲステロンが作用することにより生じる。悪性所見と類似した肉眼的所見を呈することがあるため,鑑別や治療方針の決定に難渋することがある。今回我々は,分娩後の子宮全摘術時に偶然発見され,腹膜癌との鑑別が困難であった異所性脱落膜の一例を経験したため,文献的考察とともに報告する。症例は,39歳,2妊1産,妊娠初期に子宮体部後壁に内膜を圧排する粘膜下筋腫を認めていた。妊娠40週0日に陣痛誘発目的に入院し翌日経腟分娩となったが,胎盤娩出後より出血の増加を認めた。経腹超音波検査にて子宮頸部に6cm大の筋腫を認め,筋腫分娩が疑われた。子宮収縮薬投与や子宮用止血バルーン挿入を行ったが止血は得られず,分娩6時間後に子宮全摘術を決定した。術中にダグラス窩,子宮,直腸からS状結腸漿膜面に散在する集簇性小結節を認め,肉眼的には腹膜播種に類似しており腹膜癌などの悪性腫瘍を否定できなかった。子宮全摘術と小結節の一部生検を行い,手術終了とした。病理組織学的検査では異所性脱落膜の診断であり,悪性所見を認めなかった。術後経過問題なく,1週間後に退院となった。異所性脱落膜は悪性腫瘍と類似した所見を呈する場合があるが,確立された鑑別方法はなく,現時点では病理組織学的診断が不可欠である。本邦での報告は稀ではあるが,妊娠中ないし産褥期の女性において悪性腫瘍との鑑別が必要な病態の1つとして異所性脱落膜があることを認識しておくことが重要であると考える。(著者抄録)

子宮内異物・腟閉鎖症例に対して腹腔鏡下子宮全摘術を施行した一例

黒川 晶子, 玉手 雅人, 西村 庸子, 秋元 太志, 松浦 基樹, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  28 ( 7 ) 3044 - 3044  2023年12月

腟に発症したPEComaの1例

小谷松 紗弓, 松浦 基樹, 西村 庸子, 秋元 太志, 磯山 響子, 玉手 雅人, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  67 ( 1 ) 89 - 89  2023年12月

分娩後の子宮全摘出術時に発見され,腹膜癌との鑑別が困難であった異所性脱落膜の1例

有元 千紘, 長尾 沙智子, 山崎 智子, 玉手 雅人, 高田 さくら, 松浦 基樹, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  67 ( 1 ) 85 - 86  2023年12月

婦人科良性疾患に対するロボット支援手術の在り方 良性婦人科ロボット手術の進むべき道筋

松浦 基樹, 長尾 沙智子, 黒川 晶子, 玉手 雅人, 秋元 太志, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  28 ( 7 ) 811 - 811  2023年12月

待機療法にて管理したHypervascular RPOCの3例

堀 清貴, 山崎 智子, 有元 千紘, 長尾 沙智子, 玉手 雅人, 高田 さくら, 松浦 基樹, 斎藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  67 ( 1 ) 86 - 87  2023年12月

婦人科内視鏡技術認定医が不在である当院でのTLHの取り組み

西森 貢隆, 嶋田 浩志, 藤部 佑哉, 鈴木 美紀, 玉手 雅人, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  67 ( 1 ) 91 - 91  2023年12月

Identification of cancer driver mutations in liquid-based cytology samples for the screening of endometrial diseases

Motoki Matsuura, Kiyoko Takane, Kiyoshi Yamaguchi, Tsuneo Ikenoue, Seira Hatakeyama, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Masahiro Iwasaki, Shintaro Sugita, Tadashi Hasegawa, Yasunori Ota, Tsuyoshi Saito, Yoichi Furukawa

BJC Reports ( Springer Science and Business Media LLC )  1 ( 1 )  2023年11月

　概要を見る

Abstract Background Endometrial cancer (EC) is one of the leading causes of cancer death among women and early detection is crucial for its successful treatment. We previously showed that cytological examination combined with genetic analysis using liquid-based cytology (LBC) samples improved the diagnostic sensitivity of EC. Methods Among 218 individuals who underwent endometrial screening by LBC, 208 samples were analysed by cancer-panel sequencing. Excluding 13 samples with low sequence coverage, we further analysed 195 samples. Results Among the 195 women analysed, 39 and 15 were eventually shown to suffer from malignant endometrial and non-endometrial neoplasms, respectively. Driver mutation(s) were found in nine of the 15 cytology-negative patients with endometrial malignancy, corroborating that combination of cytological and genetic analyses should increase the sensitivity of the diagnosis of malignant endometrial neoplasms. Importantly, driver alterations were found in 32 of 125 women without malignant or premalignant diseases, which raises caution for the interpretation of genetic alterations detected in the endometrial samples. Comparison between the driver mutations in the 32 subjects and those in the 29 endometrial malignancies unveiled that the number of mutations and mutations in PTEN, CTNNB1, and TP53 may be applied for the assessment and prediction of development of EC. Conclusions The genetic analysis combined with liquid-based cytology is useful to improve the diagnostic sensitivity of endometrial neoplasms. However, caution must be taken when cancer-associated mutation(s) are detected in the genetic analysis. Further investigation may clarify the risk of malignant endometrial neoplasms in women with driver mutation(s).

DOI

【婦人科悪性腫瘍手術-トラブルシューティングとその予防法-】単純外陰切除術

齋藤 豪, 松浦 基樹, 玉手 雅人, 真里谷 奨

産婦人科の実際 ( 金原出版(株) )  72 ( 12 ) 1397 - 1401  2023年11月

Study on the prevalence and subtypes of human papillomavirus infection among women in the Xuhui District, Shanghai City, China.

Han Liu, Chao Zeng, Mingming Jiang, Yue Dai, Minyi Xu, Fangfang Zhou, Yaling Wang, Alessandra Pulliero, Tomasz Sobierajski, Whitney Nesser, Motoki Matsuura, Lei Wang, Jiaying Wu, Muyuan Ji

Translational cancer research   12 ( 10 ) 2923 - 2931  2023年10月  [国際誌]

　概要を見る

BACKGROUND: Human papillomavirus (HPV) can cause various gynecological diseases, create a long-term inflammatory immune microenvironment, and induce the occurrence of cervical tumors. However, the prevalence of HPV is species-specific in different eras or in different countries and regions. This paper aimed to investigate the characteristics of HPV infection in the Xuhui District, Shanghai City, China. METHODS: We collected HPV data from 6,760 female testers, focusing on the younger population for data analysis. We focused more on the HPV subtypes to which young women were susceptible, performed t-Distributed Stochastic Neighbor Embedding (TSNE) analysis to screen for characteristic subtypes, and compared the prevalent subtypes lacking effective vaccine protection. RESULTS: HPV infection exhibited a trend of affecting a younger population, and eight subtypes were more likely to occur in young people. HPV43, 51, 53, and 59 showed a higher incidence and lacked vaccine protection. We performed TSNE dimensionality reduction analysis to organize the HPV data. The results indicated that HPV16, 18, and 51 are characteristic subtypes in the younger population. The Thinprep cytologic test (TCT) also revealed that the infection with HPV43, 51, 53, and 59 also triggers significant pathological phenotypes. CONCLUSIONS: HPV51 is a subtype that occurs more frequently in young women, can induce a variety of significant pathological features, and lacks effective vaccine protection. This study inspires us to take measures to deal with HPV rejuvenation and conduct research on vaccines for specific HPV subtypes.

DOI PubMed

ASO Visual Abstract: EGFR Mutation is a Prognostic Factor in Lung Cancer Patients with Pleural Dissemination Detected During or After Surgery.

Toshiya Fujiwara, Kazuhiko Shien, Motoki Matsuura, Junichi Soh, Hiromasa Yamamoto, Soshi Takao, Yuho Maki, Tsuyoshi Ueno, Ryujiro Sugimoto, Ken Suzawa, Mikio Okazaki, Hiroyuki Tao, Makio Hayama, Masafumi Kataoka, Yoshifumi Sano, Hidetoshi Inokawa, Motohiro Yamashita, Osamu Kawamata, Kazuhiko Kataoka, Shinichi Toyooka

Annals of surgical oncology   30 ( 11 ) 6705 - 6706  2023年10月  [国際誌]

DOI PubMed

卵巣癌に対するPARP阻害薬の中期成績と有害事象・内服アドヒアランスの関係性の検討

萬 和馬, 松浦 基樹, 有元 千紘, 黒川 晶子, 玉手 雅人, 齋藤 豪

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  61回   O65 - 5  2023年10月

子宮移植実現に向けた献体トレーニング

玉手 雅人, 松浦 基樹, 長尾 沙智子, 黒川 晶子, 秋元 太志, 馬場 剛, 齋藤 豪

Organ Biology ( (一社)日本臓器保存生物医学会 )  30 ( 3 ) 111 - 111  2023年10月

小腸癌の子宮転移の一例

長尾 沙智子, 黒川 晶子, 玉手 雅人, 幅田 周太朗, 秋元 太志, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  62 ( Suppl.2 ) 525 - 525  2023年10月

EGFR Mutation is a Prognostic Factor in Lung Cancer Patients with Pleural Dissemination Detected During or After Surgery.

Toshiya Fujiwara, Kazuhiko Shien, Motoki Matsuura, Junichi Soh, Hiromasa Yamamoto, Soshi Takao, Yuho Maki, Tsuyoshi Ueno, Ryujiro Sugimoto, Ken Suzawa, Mikio Okazaki, Hiroyuki Tao, Makio Hayama, Masafumi Kataoka, Yoshifumi Sano, Hidetoshi Inokawa, Motohiro Yamashita, Osamu Kawamata, Kazuhiko Kataoka, Shinichi Toyooka

Annals of surgical oncology   30 ( 11 ) 6697 - 6702  2023年10月  [国際誌]

　概要を見る

BACKGROUND: Primary lung tumors are sometimes resected when either pleural dissemination (PD) or malignant pleural effusion (MPE) exists. This study clarified the prognostic factors for non-small cell lung cancer (NSCLC) with either PD and MPE, or both, detected during or after surgery. PATIENTS AND METHODS: We examined patients with NSCLC from a multicenter database who had either PD, MPE, or both, detected during or after surgery between 2005 and 2015. Hazard ratios and 95% confidence intervals were estimated using the Cox proportional hazards model adjusted for potential confounding factors. RESULTS: Among 9463 registered patients, PD, MPE, or both, were found in 114 patients with NSCLC during or after surgery. Primary tumor resection and exploratory thoracotomy were performed in 65 and 49 patients, respectively. In univariate analysis, adenocarcinoma, clinically undetected lymph node metastasis (c-N0 or unknown), EGFR mutation, and combination of chemotherapy or tyrosine kinase inhibitors after surgery were better prognostic factors for overall survival (OS), whereas in the multivariate analysis, adenocarcinoma, clinically undetected lymph node metastasis, and EGFR mutation were favorable independent prognostic factors in OS. Additionally, limited to patients with EGFR mutation, patients with primary lung tumor resection showed a significantly better 5-year OS than those with exploratory thoracotomy (86.4 vs. 44.8%; p < 0.001). CONCLUSION: Our findings show that surgical resection of primary tumors could improve the prognosis of patients with PD, MPE, or both, detected during or after surgery when the tumors harbor an EGFR mutation.

DOI PubMed

Nationwide trends in and regional factors associated with minimally invasive hysterectomy for benign indications in Japan.

Kyoko Isoyama, Motoki Matsuura, Misa Hayasaka, Sachiko Nagao, Yoko Nishimura, Toshiki Yoshioka, Yuichi Imai, Etsuko Miyagi, Yukio Suzuki, Tsuyoshi Saito

European journal of obstetrics, gynecology, and reproductive biology   289   129 - 135  2023年10月  [国際誌]

　概要を見る

OBJECTIVE: To examine the prevalence trends of minimally invasive hysterectomy for benign indications in Japan and investigate regional disparities. STUDY DESIGN: A retrospective cohort and ecological study using "The National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) Open Data". SETTING: Nationwide Japan. PATIENTS: Individuals who underwent hysterectomy for benign indications from 2014 to 2020. INTERVENTIONS: Trend analysis of minimally invasive surgery (MIS) rates through laparoscopic hysterectomies (LH) and robotic-assisted laparoscopic hysterectomies (RA-LH) at the national and prefecture levels. Examination of regional factors contributing to the disparity in MIS implementation rates by second medical service area (SMSA). RESULTS: The number of LH has increased from 16,016 in 2014 to 27,755 in 2020. The nationwide MIS hysterectomy rate increased from 29% in 2014 to 55% in 2020 (p less than 0.001). More than 50% of hysterectomies have been performed as MIS since 2019. There was an increasing trend in MIS rates in all age groups. All prefectures except one showed a significant upward trend (p less than 0.05) in the MIS rates, but MIS rates varied widely (23-84%). In a multivariable model, the MIS was more likely to be performed in the SMSAs in western Japan (p = 0.011), in the SMSAs where the number of laparoscopy-qualified gynecologists is 5-10 (p = 0.013), and 11 or higher (p less than 0.001). CONCLUSIONS: This study reveals a shift towards minimally invasive surgery (MIS) in total hysterectomy procedures in Japan. However, significant disparities in the prevalence of MIS hysterectomy exist, potentially influenced by the number of laparoscopy-qualified gynecologists.

DOI PubMed

子宮原発骨肉腫の1例

南 香穂, 嶋田 浩志, 今 沙織, 鈴木 美紀, 玉手 雅人, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  70回   65 - 65  2023年09月

Laparoscopic retrovesical lower uterine segment bypass for hysterectomy with previous caesarean section: Hung Up the Bladder Bypass (HUBB) technique.

Masato Tamate, Motoki Matsuura, Nagisa Wada, Takaki Adachi, Kazuma Yorozu, Chihiro Arimoto, Tsuyoshi Saito

Journal of gynecology obstetrics and human reproduction     102629 - 102629  2023年07月  [国際誌]

　概要を見る

Patients with a history of cesarean section and a highly adherent bladder may have difficulty in bladder dissection and may suffer damage. It may also be difficult to orient the patient for repair in the event of damage. In such cases, dissection from the side between the bladder and cervix is a good way to avoid complication. This video reviews the steps of the HUBB technique procedure, provides tips and tricks for performing a successful adhesiolysis, and illustrates the procedure's adaptability. The first is the identification of the uterine artery and its position. Step2, a Laparoscopic retrovesical lower uterine segment bypass is created. Step3 a Hung Up the Bladder Bypass is created, the bladder is completely dissected. Step4, an adhesiolysis and leak test is performed. In this report, we would like to introduce a technique for creating a retrovesical lower uterine segment bypass using a laparoscope and traction on the bypass to dissect the bladder.

DOI PubMed

当科における卵巣組織凍結の現状報告と北海道における小児科医の卵巣組織凍結に対する意識調査

長尾 沙智子, 玉手 雅人, 春日 芙貴子, 西村 庸子, 松浦 基樹, 久野 芳佳, 馬場 剛, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   387 - 387  2023年07月

当院における婦人科癌に対するがん遺伝子パネル検査の現状と課題

野藤 五沙, 真里谷 奨, 田中 佑弥, 室田 文子, 寺本 瑞絵, 松浦 基樹, 岩崎 雅宏, 石川 亜貴, 高田 弘一, 櫻井 晃洋, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   288 - 288  2023年07月

【AIがもたらす婦人科癌医療の新展開】深層学習を利用したHE染色からの子宮内膜癌MMR status判定の可否に関する検討

梅本 美菜, 真里谷 奨, 永田 舞, 堀米 俊弘, 新開 翔太, 杉田 真太朗, 金関 貴幸, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 長谷川 匡, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   153 - 153  2023年07月

【我々はこうしている～子宮頸癌手術におけるMISの工夫】我々が行う子宮頸癌に対する腹腔鏡下広汎子宮全摘術の工夫

松浦 基樹, 玉手 雅人, 長尾 沙智子, 黒川 晶子, 秋元 太志, 諸井 明仁, 幅田 周太朗, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   160 - 160  2023年07月

子宮頸部腺癌の生検組織における間質線維化反応の臨床的意義

秋元 太志, 松浦 基樹, 玉手 雅人, 岩崎 雅宏, 幅田 周太朗, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   316 - 316  2023年07月

献体による手術トレーニングの立ち上げと運営のコツ-本邦の手術を今後も安全かつ世界最高水準で続けるために 日本の持続的CSTに必要な横断的で多角的な思考とは?

玉手 雅人, 松浦 基樹, 齋藤 豪

医学教育 ( (一社)日本医学教育学会 )  54 ( Suppl. ) 72 - 72  2023年07月

プラチナ感受性再発卵巣がんに対するオラパリブ,ニラパリブ維持療法の比較検討

有元 千紘, 松浦 基樹, 足立 岳貴, 萬 和馬, 黒川 晶子, 西村 庸子, 玉手 雅人, 磯山 響子, 秋元 太志, 幅田 周太朗, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  65回   350 - 350  2023年07月

Cervical conization with endoCUT mode applying gastrointestinal endoscopic polypectomy technique.

Masato Tamate, Motoki Matsuura, Tsuyoshi Saito

Obstetrics & gynecology science    2023年06月  [国際誌]

　概要を見る

OBJECTIVE: To show how endoCUT (COMPANY, CITY, STATE, COUNTRY) mode can be safely managed with cervical conization. METHODS: Demonstration of the technique and explanation of endoCUT and soft coagulation mode with narrated video footage. Cervical conization is a therapeutic and diagnostic procedure performed for the diagnosis of cervical intraepithelial lesions and cervical cancer. Specific methods include cold scalpel, ultrasonically activated device and laser, and loop electrosurgical excision procedure (LEEP), which involves transpiration and partial excision. The endoCUT mode and soft coagulation in VIO3 (COMPANY, CITY, STATE, COUNTRY) were used to perform cervical conical resection safely and at low cost (Fig. 1). The endoCUT mode was originally developed for polypectomy in gastrointestinal endoscopy, where no counter traction can be applied [1,2]. RESULTS: The endoCUT mode approach to cervical conization with several key strategies to minimize blood loss and ensure safety: 1) incisions can be made in close contact; 2) resection can be performed with minimal contact with the lesion; 3) control of bleeding from the resected transection by soft coagulation; and 4) low running cost of endoCUT mode. CONCLUSION: Conventionally, cervical conical resection has been performed by using a device capable of making a close incision (cold scalpel, ultrasonically activated device and laser, and LEEP etc.), but there have been issues with bleeding control and cost. Here, we present a new technique using the endoCUT mode and several strategies for safe and effective resection.

DOI PubMed

Therapeutic efficacy of a four-year treatment with eribulin in a patient with uterine leiomyosarcoma: A case report.

Motoki Matsuura, Kazuma Yorozu, Sachiko Nagao, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Tsuyoshi Saito

Gynecologic oncology reports   47   101205 - 101205  2023年06月  [国際誌]

　概要を見る

Uterine leiomyosarcoma (LMS) is a gynecological malignancy with an extremely poor prognosis. Multiple new therapeutic agents, including pazopanib, trabectedin, and eribulin, have been clinically applied to treat uterine LMS, and their therapeutic effects are expected. We encountered one patient with advanced recurrent uterine LMS who achieved a partial response to a four-year treatment with eribulin. A 31-year-old woman was diagnosed with stage 2B LMS. After the first recurrence, Gemcitabine, Docetaxel (GD) therapy was administered, and complete response (CR) was achieved. However, 2 years and 10 months later, recurrence occurred at the vaginal cuff, and GD therapy and doxorubicin hydrochloride were administered, resulting in CR. Five months later, she experienced another recurrence at the same location and was treated with eribulin. To date, 53 courses of eribulin have been administered and are currently ongoing. Maintaining low neutrophil-to-lymphocyte ratio and low platelet-to lymphocyte ratio in this manner is considered to be one of the reasons why eribulin continues to be effective. We encountered a rare case in which eribulin was administered for the longest period of time, and produced an observable effect in uterine LMS.

DOI PubMed

Aggressive angiomyxoma(AAM)合併妊娠の一例

古来 愛香, 石岡 伸一, 新開 翔太, 常松 梨紗, 真里谷 奨, 染谷 真行, 松浦 基樹, 馬場 剛, 齋藤 剛

日本周産期・新生児医学会雑誌 ( (一社)日本周産期・新生児医学会 )  59 ( Suppl.1 ) P438 - P438  2023年06月

深層学習によるHE染色データを用いた子宮内膜癌プロファイル判定の適否に関する検討

梅本 美菜, 真里谷 奨, 永田 舞, 堀米 俊弘, 新開 翔太, 杉田 真太朗, 金関 貴幸, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 長谷川 匡, 鳥越 俊彦, 齋藤 豪, 藤野 雄一

日本医療情報学会春季学術大会プログラム・抄録集 ( (一社)日本医療情報学会 )  27回   122 - 123  2023年06月

Thiel法固定献体における子宮移植

玉手 雅人, 松浦 基樹, 和田 渚, 足立 岳貴, 有元 千紘, 黒川 晶子, 西村 庸子, 秋元 太志, 木須 伊織, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 34 ) 146 - 146  2023年06月

TLHにおける非利き手の有効率を検証する

和田 渚, 玉手 雅人, 有元 千紘, 鹿内 智史, 杉田 奈穂子, 鈴木 将裕, 松浦 基樹, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 34 ) 163 - 163  2023年06月

機能再建手術 Thiel法固定献体における子宮移植トレーニング

玉手 雅人, 松浦 基樹, 木須 伊織, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 34 ) 73 - 78  2023年06月

「助手力」の教育 助手力を構成する要素とは何か,どのように教育するのか

梅本 美菜, 松浦 基樹, 足立 岳貴, 有本 千紘, 黒川 晶子, 西村 庸子, 玉手 雅人, 秋元 太志, 幅田 周太朗, 岩崎 雅弘, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 34 ) 162 - 162  2023年06月

「助手力」の教育 助手力を構成する要素とは何か,どのように教育するのか

梅本 美菜, 松浦 基樹, 足立 岳貴, 有本 千紘, 黒川 晶子, 西村 庸子, 玉手 雅人, 秋元 太志, 幅田 周太朗, 岩崎 雅弘, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 34 ) 162 - 162  2023年06月

深層学習によるHE染色データを用いた子宮内膜癌プロファイル判定の適否に関する検討

梅本 美菜, 真里谷 奨, 永田 舞, 堀米 俊弘, 新開 翔太, 杉田 真太朗, 金関 貴幸, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 長谷川 匡, 鳥越 俊彦, 齋藤 豪, 藤野 雄一

日本医療情報学会春季学術大会プログラム・抄録集 ( (一社)日本医療情報学会 )  27回   122 - 123  2023年06月

卵巣癌・子宮体癌症例における細胞診検体(LBC検体を含む)を用いたNGSの有用性 LBC検体によるNGSを子宮体癌早期スクリーニングにどう応用するべきか

松浦 基樹, 玉手 雅人, 秋元 太志, 幅田 周太朗, 岩崎 雅宏, 畠山 晴良, 高根 希世子, 山口 貴世志, 古川 洋一, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  62 ( Suppl.1 ) 174 - 174  2023年05月

腹腔鏡下子宮筋腫核出術後に発生した多発parasitic myomaの1例

岩崎 雅宏, 幅田 周太朗, 野藤 五沙, 松浦 基樹, 玉手 雅人, 齋藤 豪

産婦人科の実際 ( 金原出版(株) )  72 ( 5 ) 533 - 536  2023年05月

　概要を見る

＜文献概要＞Parasitic myomaは,筋腫が子宮と遊離した状態で他の臓器からの栄養血管を得て生着する疾患である。症例はモルセレーターを用いた腹腔鏡下子宮筋腫核出術既往がある47歳女性で,子宮筋腫の増大を認めたため腹式単純子宮全摘出術を施行した際,多発性の子宮と連続性のない筋腫parasitic myomaを認めた。モルセレーターを用いた腹腔鏡下子宮全摘出術や腹腔鏡下子宮筋腫核出術ではparasitic myomaを予防するため,組織飛散防止回収袋を用いた回収や十分な腹腔内洗浄を心がける必要がある。

Improvement in radiation techniques for locally advanced cervical cancer during the last two decades.

Satoru Sagae, Takafumi Toita, Motoki Matsuura, Manabu Saito, Takuma Matsuda, Nanaka Sato, Ayumi Shimizu, Toshiaki Endo, Miho Fujii, David K Gaffney, William Small Jr

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society    2023年04月  [国際誌]

　概要を見る

Since the National Cancer Institute (NCI) alert of concurrent chemoradiotherapy, radiotherapy has been changed from external beam radiotherapy plus brachytherapy to platinum-based concurrent chemoradiotherapy. Therefore, concurrent chemoradiotherapy plus brachytherapy has become a standard treatment for locally advanced cervical cancer. Simultaneously, definitive radiotherapy has been changed gradually from external beam radiotherapy plus low-dose-rate intracavitary brachytherapy to external beam radiotherapy plus high-dose-rate intracavitary brachytherapy. Cervix cancer is uncommon in developed countries; hence, international collaborations have been critical in large-scale clinical trials. The Cervical Cancer Research Network (CCRN), created from the Gynecologic Cancer InterGroup (GCIG), has investigated various concurrent chemotherapy regimens and sequential methods of radiation and chemotherapy. Most recently, many clinical trials of combining immune checkpoint inhibitors with radiotherapy have been ongoing for sequential or concurrent settings. During the last decade, the method of standard radiation therapy has changed from three-dimensional conformal radiation therapy to intensity-modulated radiation therapy for external beam radiotherapy and from two-dimensional to three-dimensional image-guided approaches for brachytherapy. Recent improvements include stereotactic ablative body radiotherapy and MRI-guided linear accelerator (MRI-LINAC) using adaptive radiotherapy. Here we review the current progress of radiation therapy during the last two decades.

DOI PubMed

Revaluation of a selected segmental insufflation technique in total thoracoscopic lung segmentectomy.

Jun Suzuki, Hiroyuki Oizumi, Hikaru Watanabe, Satoshi Takamori, Toshiya Fujiwara, Motoki Matsuura

Interdisciplinary cardiovascular and thoracic surgery   36 ( 4 )  2023年04月  [国際誌]

　概要を見る

We report selected insufflation technique using direct bronchial insufflation to visualize the intersegmental plane during total thoracoscopic segmentectomy. Following the transection of the bronchus using a stapler, a small incision was created in the dissected target bronchus, and direct air insufflation was performed at the small incision site. The target segment was inflated, while the preserved segments appeared to collapse, and a demarcating line was visualized between the inflated and deflated lung parenchyma. This technique quickly identifies the anatomic intersegmental plane without warranting special equipment such as jet ventilation or indocyanine green (ICG). Furthermore, this method saves time in creating inflation-deflation lines.

DOI PubMed

Mailing human papillomavirus self-sampling kits to women under-screened for cervical cancer improved detection in cervical cancer screening in a general population study in Japan.

Yoko Nishimura, Motoki Matsuura, Noriko Terada, Sachiko Nagao, Hiroshi Shimada, Kyoko Isoyama, Masato Tamate, Masahiro Iwasaki, Tsuyoshi Saito

BMC public health   23 ( 1 ) 473 - 473  2023年03月  [国際誌]

　概要を見る

BACKGROUND: One cause of the increase in cervical cancer rates in Japan is the long-term stagnation in the cervical cancer screening consultation rate. Therefore, improving the screening consultation rate is of urgent concern to reduce cervical cancer incidence. Self-collected human papilloma virus (HPV) tests have been successfully adopted in several countries, such as the Netherlands and Australia, as a measure of individuals who have not undergone cervical cancer screening in national programs. This study aimed to verify whether self-collected HPV tests presented an effective countermeasure for individuals who had not undergone the recommended cervical cancer screenings. METHODS: This study was conducted from December 2020 to September 2022 in Muroran City, Japan. The primary evaluated endpoint was the percentage of citizens who underwent cervical cancer screening at a hospital with positive self-collected HPV test results. The secondary endpoint was the percentage of included participants who were diagnosed with cervical intraepithelial neoplasia (CIN) or higher among those who visited a hospital and underwent cervical cancer screening. RESULTS: The included study participants were 7,653 individuals aged 20-50 years with no record of previous cervical cancer examination in the past 5 years. We mailed these participants information on self-administered HPV tests as an alternative screening procedure and sent the kit to 1,674 women who requested the test. Among them, 953 returned the kit. Among the 89 HPV-positive individuals (positive rate, 9.3%), 71 (79.8%) visited the designated hospital for an examination. A closer examination revealed that 13 women (18.3% of hospital visits) had a CIN finding of CIN2 or higher, among whom one each had cervical cancer and vulvar cancer, eight presented with CIN3, and three presented with CIN2; two cases of invasive gynecologic cancer were also identified. CONCLUSIONS: We conclude that the self-collected HPV tests showed a certain efficacy as a measure of individuals who had not undergone the recommended cervical cancer screening. We devised ways to have the unexamined patients undergo HPV testing and ensure that HPV-positive individuals visited the hospital. Despite a few limitations, our findings suggest the effectiveness of this public health intervention.

DOI PubMed

Surgical outcome of ipsilateral anatomical resection for lung cancer after pulmonary lobectomy.

Mikio Okazaki, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Kota Araki, Mototsugu Watanabe, Masanori Okada, Yuho Maki, Tsuyoshi Ueno, Shinji Otani, Ryujiro Sugimoto, Hitoshi Nishikawa, Riki Okita, Makio Hayama, Hiroyuki Tao, Toshiya Fujiwara, Hidetoshi Inokawa, Yuji Hirami, Yoshifumi Sano, Motohiro Yamashita, Osamu Kawamata, Motoki Matsuura, Shinichi Toyooka

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery   63 ( 3 )  2023年03月  [国際誌]

　概要を見る

OBJECTIVES: Ipsilateral reoperation after pulmonary lobectomy is often challenging because of adhesions from the previous operation. We retrospectively examined the surgical outcome and prognosis of ipsilateral anatomical resection for lung cancer after pulmonary lobectomy using a multicentre database. METHODS: We evaluated the perioperative outcomes and overall survival of 51 patients who underwent pulmonary lobectomy followed by ipsilateral anatomical resection for lung cancer between January 2012 and December 2018. In addition, patients with stage I non-small-cell lung cancer (NSCLC) were compared with 3411 patients with stage I lung cancer who underwent pulmonary resection without a prior ipsilateral lobectomy. RESULTS: Ipsilateral anatomical resections included 10 completion pneumonectomies, 19 pulmonary lobectomies and 22 pulmonary segmentectomies. Operative time was 312.2 ± 134.5 min, and intraoperative bleeding was 522.2 ± 797.5 ml. Intraoperative and postoperative complications occurred in 9 and 15 patients, respectively. However, the 5-year overall survival rate after anatomical resection followed by ipsilateral lobectomy was 83.5%. Furthermore, in patients with c-stage I NSCLC, anatomical resection followed by ipsilateral lobectomy was not associated with worse survival than anatomical resection without prior ipsilateral lobectomy. CONCLUSIONS: Anatomical resection following ipsilateral lobectomy is associated with a high frequency of intraoperative and postoperative complications. However, the 5-year overall survival in patients with c-stage I NSCLC who underwent ipsilateral anatomical resection after pulmonary lobectomy is comparable to that in patients who underwent anatomical resection without prior pulmonary lobectomy.

DOI PubMed

深層学習を用いたHE染色からの子宮内膜癌分子生物学的プロファイル推定の適否に関する検討

梅本 美菜, 真里谷 奨, 新開 翔太, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  75 ( 臨増 ) S - 260  2023年02月

深層学習を用いたHE染色からの子宮内膜癌分子生物学的プロファイル推定の適否に関する検討

梅本 美菜, 真里谷 奨, 新開 翔太, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  75 ( 臨増 ) S - 260  2023年02月

帝王切開後高度癒着症例に対する腹腔鏡下子宮全摘術における,Retrovesical Lower Uterine Segment Bypassと検討

有元 千紘, 玉手 雅人, 足立 岳貴, 黒川 晶子, 西村 庸子, 秋元 太志, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  75 ( 臨増 ) S - 278  2023年02月

卵巣癌に対するPARP阻害薬の中期成績と有害事象・内服アドヒアランスの関係性に関する検討

萬 和馬, 松浦 基樹, 有元 千紘, 黒川 晶子, 玉手 雅人, 秋元 太志, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  75 ( 臨増 ) S - 292  2023年02月

当科における卵巣組織凍結の現状報告と北海道における小児科医の卵巣組織凍結に対する意識調査

古来 愛香, 玉手 雅人, 春日 芙貴子, 長尾 沙智子, 西村 庸子, 松浦 基樹, 久野 芳佳, 馬場 剛, 齋藤 豪

日本がん・生殖医療学会誌 ( (一社)日本がん・生殖医療学会 )  6 ( 1 ) 49 - 53  2023年02月

　概要を見る

【緒言】小児・思春期・若年成人(children,adolescents and young adults:C-AYA)世代のがんサバイバーが増加することにともない、QOL向上の意識が高まり妊孕性温存法も発展しつつある。当科では、小児がん患者の卵巣組織凍結保存を実施してきた。今回、当院での卵巣組織凍結保存の現状報告(研究1)、および北海道内の小児科医における卵巣組織凍結に対する意識調査(研究2)について報告する。【対象と方法】研究1:2012年12月～2021年6月までに当科で卵巣組織凍結保存を目的とした卵巣摘出術手術20例を対象に、年齢、原疾患、コンサルトから手術までの期間、周術期経過、合併症などの背景を集積した。研究2:北海道内の悪性疾患を診療する小児科医に卵巣組織凍結の認識を匿名でアンケート調査した。【結果】研究1:初診時平均年齢は18.8±8.49歳。原疾患は、血液腫瘍13例、脳腫瘍3例、乳癌2例、軟部腫瘍2例であった。手術までの期間は3-99日(平均31.5±21.5日)、全例腹腔鏡手術であった。研究2:アンケートは5施設18名から回収した。卵巣組織凍結について認識している人が18名(100%)、情報提供をしたことがある人が13名(72.2%)であった。卵巣組織凍結の情報提供をしたが治療の同意が得られない理由としては、経済的理由(保険適応外)、手術のリスク、原疾患治療の遅れ、エビデンスが乏しい、などがあげられた。【結語】卵巣組織凍結保存は微小残存がん病巣(MRD:minimal residual disease)のリスクがあるが、月経発来前の女児に対して唯一の妊孕性温存療法である。しかし、社会的要因によって普及には至っていない。今後、凍結卵巣融解移植成績の発信や卵巣組織凍結の説明方法の均てん化などにより一層卵巣組織凍結という選択肢を提示していきたい。症例治療が滞りなく円滑に進むよう、主治医、生殖医、婦人科腫瘍医の連携が重要であり、今後尽力したい。(著者抄録)

化学療法抵抗性再発子宮体癌に対する当院におけるPembrolizumab/Lenvatinibの使用経験

南 怜毅, 幅田 周太朗, 有元 千紘, 堀 清貴, 萬 和馬, 野藤 五沙, 黒川 晶子, 玉手 雅人, 秋元 太志, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  75 ( 臨増 ) S - 347  2023年02月

Concurrent lung adenocarcinoma hidden among multiple shadows of COVID-19 pneumonia: A rare and instructive case report.

Yoshihiro Kitahara, Motoki Matsuura, Rie Yamasaki, Kanako Nakamoto, Shinji Kakumoto, Shinpei Tada, Noriaki Ito, Kei Miwata, Mafumi Okimoto, Toshiro Takafuta

Clinical case reports   11 ( 2 ) e6859  2023年02月  [国際誌]

　概要を見る

A 40-year-old man was admitted with a diagnosis of COVID-19 pneumonia. Although most of multiple ground-glass opacities and consolidations on computed tomography improved, a round ground-glass opacity with consolidation remained unchanged and was suspected to be a part-solid nodule of lung adenocarcinoma. Pathologic diagnosis of resected tumor was papillary adenocarcinoma.

DOI PubMed

A mixed-method evaluation of cadaver surgery training for gynecologic oncology.

Masato Tamate, Motoki Matsuura, Hiroyuki Kanao, Tsuyoshi Saito

The journal of obstetrics and gynaecology research   48 ( 12 ) 3252 - 3261  2022年12月  [国際誌]

　概要を見る

AIM: Traditional surgical training techniques with using patients, and new advances with live animals, artificial models, and simulation methods have several shortcomings. There are a few reports on the usefulness of cadaver surgery training (CST) in gynecology. Herein, we used a mixed-method evaluation to qualitatively and quantitatively explore the educational efficacy of CST by conducting CST programs at the Sapporo Medical University, Japan. METHODS: In 2020, we conducted two CST programs with 45 participants-13 residents, 8 specialists recognized by Japan Society of Obstetrics and Gynecology, 23 certified endoscopists recognized by Japan Society of Gynecology and Obstetrics Endoscopy and Minimally Invasive Therapy, 15 specialists recognized by Japan Society of Gynecologic Oncology, and 14 certified endoscopists cum oncology. Three participants observed the procedure virtually and 42 were physically present. Laparoscopic radical hysterectomy and pelvic exenteration were performed on five Thiel-embalmed cadavers. Participants were asked to complete pre- and post-training surveys that included qualitative questions, concerning the purpose and cost of CST, and quantitative questions, testing anatomical knowledge. RESULTS: We observed that the rate of score improvement to the quantitative questions increased from 58.6% pre-CST to 75.6% post-CST. Furthermore, oncology specialists and those who performed more surgeries and faced more complications during surgeries recorded high percentage of correct answers. Multiple regression analysis statistically confirmed these results. CONCLUSIONS: This study confirmed the educational efficacy of CST.

DOI PubMed

vNOTESによる膜解剖理論に基づいた直腸周囲展開

足立 岳貴, 松浦 基樹, 黒川 晶子, 西村 庸子, 玉手 雅人, 秋元 太志, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  27 ( 7 ) 599 - 599  2022年12月

Predictive value of an exosomal microRNA-based signature for tumor immunity in cervical cancer patients treated with chemoradiotherapy.

Masanori Someya, Tomokazu Hasegawa, Takaaki Tsuchiya, Mio Kitagawa, Yuki Fukushima, Toshio Gocho, Shoh Mafune, Yutaro Ikeuchi, Yoh Kozuka, Masashi Idogawa, Yoshihiko Hirohashi, Toshihiko Torigoe, Masahiro Iwasaki, Motoki Matsuura, Tsuyoshi Saito, Koh-Ichi Sakata

Medical molecular morphology   56 ( 1 ) 38 - 45  2022年11月  [国内誌]

　概要を見る

Resistance of cervical cancer to radiotherapy with concurrent chemotherapy (CCRT) results in a poor prognosis. To identify new biomarkers for predicting the treatment response and prognosis, we explored exosomal microRNA (miRNA) expression signatures associated with the outcome of cervical cancer patients treated with CCRT. Exosomes were isolated from the plasma of 45 patients prior to CCRT during 2014-2020, and miRNA analysis was performed by next-generation sequencing. At a median follow-up of 38 months, 26 patients were recurrence free, 15 patients had died of the disease, and 4 patients received salvage chemotherapy due to distant metastasis. Of the 2522 miRNAs detected, 9 (miR-148a-5p, 1915-3p, 3960, 183-5p, 196b-5p, 200c-3p, 182-5p, 374a-5p, and 431-5p) showed differential expression between the recurrence-free and recurrence groups. Patients were divided into high- and low-risk groups according to the cutoff of the miRNAs-based risk score calculated from respective expression levels. The high-risk group had significantly worse disease-specific survival than the low-risk group (p < 0.001). In addition, miR-374a-5p and miR-431-5p expression showed a weak inverse correlation with tumor-infiltrating CD8+ and FOXP3+ T cells, suggesting a potential inhibitory effect on CCRT by suppressing tumor immunity. This miRNA signature could improve non-invasive monitoring and personalized treatment for cervical cancer.

DOI PubMed

Human papillomavirus testing and cytology using physician-collected uterine cervical samples vs. self-collected vaginal samples and urine samples.

Noriko Terada, Motoki Matsuura, Shoko Kurokawa, Yoko Nishimura, Masato Tamate, Kyoko Isoyama, Satoko Yamazaki, Hiroshi Shimada, Masahiro Suzuki, Yuta Tabuchi, Mizue Teramoto, Tsuyoshi Saito

International journal of clinical oncology   27 ( 11 ) 1742 - 1749  2022年11月  [国内誌]

　概要を見る

BACKGROUND: Human papillomavirus (HPV) testing using self-collected vaginal samples and urine samples is convenient and effective for improving the screening rate. But, to serve as an alternative cervical cancer screening technique, such tests must offer sensitivity equivalent to the HPV testing of physician-collected cervical samples. To examine the effectiveness of HPV testing using self-collected samples and urine samples, we compared the results of HPV testing using these samples with those of HPV testing using physician-collected samples and cytological examinations. METHODS: The study population included 300 women (age: 20-50 years) with abnormal cervical cytology. The results of HPV testing using self-collected samples and urine samples and physician-collected samples and cervical cytology were compared. RESULTS: For all HPV types, the κ-value was 0.773 for physician- and self-collected samples and 0.575 for physician-collected and urine samples. The κ-value for HPV type 16-positive samples was 0.988 for physician- and self-collected samples and 0.896 for physician-collected and urine samples. The κ-value for HPV type 18-positive samples was 0.856 for physician- and self-collected samples and 0.831 for physician-collected and urine samples. For other HPV types, the value was 0.809 for physician- and self-collected samples and 0.617 for physician-collected and urine samples. CONCLUSIONS: The obtained results were consistent between physician- and self-collected samples as well as between physician-collected and urine samples. Considering that the agreement rate was particularly high for the high-risk HPV types 16 and 18, HPV testing using physician-collected samples, self-collected samples, and urine samples was equally effective for the types with high carcinogenicity.

DOI PubMed

子宮移植/妊娠中免疫抑制療法/胎児免疫 Thiel法固定献体における子宮移植トレーニング

玉手 雅人, 松浦 基樹, 木須 伊織, 齋藤 豪

Organ Biology ( (一社)日本臓器保存生物医学会 )  29 ( 3 ) 86 - 86  2022年11月

血中エクソソーム由来miRNAを用いた子宮頸癌の治療効果予測

染谷 正則, 土屋 高旭, 福島 悠希, 長谷川 智一, 井戸川 雅史, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 鳥越 俊彦, 齋藤 豪, 坂田 耕一

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  60回   P102 - 2  2022年10月

巨大嚢胞化し、子宮留膿腫を繰り返した帝王切開瘢痕部症候群の1例

仁木 舜一, 嶋田 浩志, 玉手 雅人, 杉山 芽, 今 沙織, 鈴木 美紀, 松浦 基樹, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  69回   112 - 112  2022年10月

子宮動脈塞栓術併用の子宮鏡下切除術において子宮内バルーニングが有用であったRPOCの一例

南 怜毅, 長尾 沙智子, 木嶋 紗弓, 小川 栞, 山崎 智子, 玉手 雅人, 松浦 基樹, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  69回   64 - 64  2022年10月

巨大嚢胞化し、子宮留膿腫を繰り返した帝王切開瘢痕部症候群の1例

仁木 舜一, 嶋田 浩志, 玉手 雅人, 杉山 芽, 今 沙織, 鈴木 美紀, 松浦 基樹, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  69回   112 - 112  2022年10月

子宮悪性軟部腫瘍に対する新規薬剤が効果を認めた症例の検討

萬 和馬, 松浦 基樹, 足立 岳貴, 有元 千紘, 黒川 晶子, 西村 庸子, 玉手 雅人, 秋元 太志, 幅田 周太朗, 岩崎 雅宏, 齋藤 豪

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  60回   O46 - 2  2022年10月

子宮頸がん検診未受診者対策としての自己採取HPV検査の有効性評価

松浦 基樹, 寺田 倫子, 西村 庸子, 玉手 雅人, 長尾 沙智子, 秋元 太志, 幅田 周太朗, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  61 ( Suppl.2 ) 477 - 477  2022年10月

子宮動脈塞栓術併用の子宮鏡下切除術において子宮内バルーニングが有用であったRPOCの一例

南 怜毅, 長尾 沙智子, 木嶋 紗弓, 小川 栞, 山崎 智子, 玉手 雅人, 松浦 基樹, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  69回   64 - 64  2022年10月

LSR antibody promotes apoptosis and disrupts epithelial barriers via signal pathways in endometrial cancer.

Kimihito Saito, Takumi Konno, Takayuki Kohno, Hiroshi Shimada, Motoki Matsuura, Tadahi Okada, Arisa Kura, Daichi Ishii, Masuo Kondoh, Tsuyoshi Saito, Takashi Kojima

Tissue barriers     2106113 - 2106113  2022年07月  [国際誌]

　概要を見る

Lipolysis-stimulated lipoprotein receptor (LSR), a lipid metabolism-related factor localized in tricellular tight junctions (tTJs), plays an important role in maintaining the epithelial barrier. LSR is highly expressed in well-differentiated endometrial endometrioid carcinoma (EEC), and its expression decreases during malignancy. Angubindin-1, a novel LSR ligand peptide, regulates tTJs without cytotoxicity, enhances paracellular permeability, and regulates epithelial barrier via c-Jun N-terminal kinase (JNK)/cofilin. In this study, we investigated the immune-modulatory roles of an anti-LSR antibody in the treatment of EEC in vitro compared to those of angubindin-1. We prepared an antibody against the extracellular N-terminal domain of human LSR (LSR-N-ab) and angubindin-1. EEC cell-line Sawano cells in 2D and 2.5D cultures were treated with 100 μg/ml LSR-N-ab or 2.5 μg/ml angubindin-1 with or without protein tyrosine kinase 2β inhibitor PF431396 (PF43) and JNK inhibitor SP600125 (SP60) at 10 μM. Treatment with LSR-N-ab and angubindin-1 decreased LSR at the membranes of tTJs and the activity of phosphorylated LSR and phosphorylated cofilin in 2D culture. Treatment with LSR-N-ab and angubindin-1 decreased the epithelial barrier measured as TEER values in 2D culture and enhanced the epithelial permeability of FD-4 in 2.5D culture. Treatment with LSR-N-ab, but not angubindin-1, induced apoptosis in 2D culture. Pretreatment with PF43 and SP60 prevented all the changes induced by treatment with LSR-N-ab and angubindin-1. Treatment with LSR-N-ab and angubindin-1 enhanced the cell metabolism measured as the mitochondrial respiration levels in 2D culture. LSR-N-ab and angubindin-1 may be useful for therapy of human EEC via enhanced apoptosis or drug absorption.

DOI PubMed

Pathological classification of desmoplastic reaction is prognostic factor in cervical adenocarcinoma.

Taishi Akimoto, Akira Takasawa, Kumi Takasawa, Tomoyuki Aoyama, Motoki Matsuura, Masato Tamate, Masahiro Iwasaki, Shutaro Habata, Taro Murakami, Makoto Osanai, Tsuyoshi Saito

Medical molecular morphology   55 ( 4 ) 275 - 282  2022年07月  [国内誌]

　概要を見る

Desmoplastic reaction (DR) and inflammation are significant pathological manifestations of tumorigenesis in several cancers. However, the correlation between these stromal reactions and cervical adenocarcinoma has been poorly documented. This investigation elucidated whether DR is a prognostic indicator in early cervical adenocarcinoma patients. Fifty-nine patients with early stage cervical adenocarcinoma (stages I/II) were included in the study. DR was divided into three groups, mature, intermediate, and immature, based on the presence of myxoid stroma and hyalinized keloid-like collagen. Inflammatory cell responses were classified as mild, moderate, and severe. Those stromal reactions were separately evaluated in the invasion front stroma and intratumoral stroma. In both the intratumor and invasion front stroma, intermediate/immature DR was correlated with tumor size, T stage, N stage, lymphovascular invasion, and parametrial infiltration (p < 0.001 to p < 0.05). In addition, in the intratumoral stroma, intermediate/immature DR led to short relapse-free survival and overall survival (p < 0.001). In the invasion front stroma, inflammatory cell responses were associated with DR immaturity and FIGO stage (p < 0.01). These results suggest that the classification of DR maturity is a potential prognostic biomarker in early stage cervical adenocarcinoma patients. DR can be evaluated by routine H&E staining without immunohistochemistry, making it convenient and economical in clinical practice.

DOI PubMed

プラチナ感受性再発卵巣がんに対するオラパリブ,ニラパリブ維持療法の比較検討

有元 千紘, 松浦 基樹, 足立 岳貴, 萬 和馬, 和田 渚, 篠原 由梨, 黒川 晶子, 西村 庸子, 玉手 雅人, 磯山 響子, 秋元 太志, 幅田 周太朗, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  64回   273 - 273  2022年07月

当院における早期子宮体癌再発症例の検討

幅田 周太朗, 岩崎 雅宏, 萬 和馬, 野藤 五沙, 玉手 雅人, 秋元 太志, 松浦 基樹, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  64回   246 - 246  2022年07月

Clinicopathological features and programmed death-ligand 1 immunohistochemical expression in a multicenter cohort of uterine and ovarian melanomas: a retrospective study in Japan (KCOG-G1701s).

Mitsutake Yano, Kaei Nasu, Masanori Yasuda, Tomomi Katoh, Masahiro Kagabu, Hisanori Kobara, Motoki Matsuura, Osamu Tokuyama, Takaharu Yamawaki, Senn Wakahashi, Tomoko Noguchi, Kaoruko Mizuno, Keiji Shitsukawa, Yoshimasa Onohara, Takashi Nakabori, Aki Miyasaka, Takehiro Nakao, Tatsuya Matsunaga, Yusuke Kunimi, Manabu Sakurai, Aya Uchiyama, Ryoji Itoh, Nobuyuki Ohike, Takashi Hirakawa, Tadashi Watanabe, Koji Nishino, Takashi Motohashi, Kimihiko Ito

Melanoma research   32 ( 3 ) 150 - 158  2022年06月  [国際誌]

　概要を見る

The objective of this study was to propose prognostic factors and optimal treatment strategies by analyzing the clinicopathological features and programmed death-ligand 1 (PD-L1) expression. We analyzed 31 patients diagnosed with uterine or ovarian melanoma between 1997 and 2017 in the Kansai Clinical Oncology Group/Intergroup. Twenty-four and seven patients with cervical and ovarian melanomas were included, respectively. Immune checkpoint inhibitors were used in seven patients, and the objective response rate was 40%. Notably, two patients with objective responses had a high PD-L1 expression. Ten and four patients with cervical and ovarian melanomas, respectively, had high PD-L1 immunohistochemical expressions. Multivariate analysis revealed that tumor stage was an independent prognostic factor for progression-free survival in patients with cervical melanomas. In patients with ovarian melanomas, the 1-year cumulative progression-free and overall survival rates were 0 and 29%, respectively. Kaplan-Meier analyses revealed that age <60 years was associated with poorer progression-free and overall survivals in patients with ovarian melanomas. In patients with cervical melanomas, the 1-, 3-, and 5-year cumulative overall survival rates were 53, 32, and 16%, respectively. Histological atypia was associated with a poorer progression-free survival, but there was no difference in survival between patients who underwent radical hysterectomy and those who did not. The present study is a large cohort study of uterine and ovarian melanomas, which are aggressive tumors with a significantly poor prognosis, even after standard surgery and adjuvant therapy. The use of immune checkpoint inhibitors is a promising and effective treatment option.

DOI PubMed

Treatment specialty-specific characteristics and outcomes in women with vulvo-vaginal melanoma: A JGOG-JSCS joint study.

Koji Matsuo, Shin Nishio, Dai Ogata, Tomoyasu Kato, Motoki Matsuura, Mikio Mikami, Takayuki Enomoto

Journal of surgical oncology   125 ( 8 ) 1333 - 1337  2022年06月  [国際誌]

DOI PubMed

サードアームを有効活用した後方アプローチによるロボット支援下子宮全摘術

松浦 基樹, 西村 庸子, 玉手 雅人, 磯山 響子, 秋元 太志, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 33 ) 152 - 152  2022年06月

帝王切開瘢痕部妊娠に対する一期的修復術の工夫

齋藤 晋平, 玉手 雅人, 西村 庸子, 磯山 響子, 幅田 周太郎, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 33 ) 129 - 129  2022年06月

失敗から学ぶ 手術におけるわれわれの取組みやコツ 開腹、腟式 帝王切開瘢痕部妊娠に対する 一期的修復術の工夫

齋藤 晋平, 玉手 雅人, 松浦 基樹, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 33 ) 13 - 17  2022年06月

Radiotherapy for HPV-related cancers: prediction of therapeutic effects based on the mechanism of tumor immunity and the application of immunoradiotherapy.

Masanori Someya, Yuki Fukushima, Tomokazu Hasegawa, Takaaki Tsuchiya, Mio Kitagawa, Toshio Gocho, Shoh Mafune, Yutaro Ikeuchi, Yoh Kozuka, Yoshihiko Hirohashi, Toshihiko Torigoe, Masahiro Iwasaki, Motoki Matsuura, Tsuyoshi Saito, Koh-Ichi Sakata

Japanese journal of radiology   40 ( 5 ) 458 - 465  2022年05月  [国内誌]

　概要を見る

Human papillomavirus (HPV)-related cancer is one of the diseases entities for which the applications of radiotherapy have been increasing. Recently, the process of carcinogenesis from HPV infection and the mechanism of tumor immunity that develops during disease progression have been elucidated. In this review, we will describe the mechanism of tumor immunity and how chemoradiotherapy may overcome and improve the efficacy of tumor immunity. We will also discuss the usefulness of proteins involved with tumor immunity as a predictive marker of radiotherapy response, and present an overview of ongoing clinical trials of combinations of immune checkpoint inhibitors and radiotherapy to demonstrate the promising combination therapy that has been currently emerging.

DOI PubMed

がん・生殖手術の未来図 当院における子宮頸がんに対するがん生殖技術の足取りと未来図

玉手 雅人, 松浦 基樹, 足立 岳貴, 有元 千紘, 西村 庸子, 黒川 晶子, 秋元 太志, 齋藤 豪

日本外科系連合学会誌 ( 日本外科系連合学会 )  47 ( 3 ) 404 - 404  2022年05月

当院における妊孕性温存手術後の癒着因子の抽出とアウトカム

和田 渚, 玉手 雅人, 木島 紗弓, 篠原 由梨, 西村 庸子, 磯山 響子, 秋元 太志, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  74 ( 臨増 ) S - 344  2022年02月

子宮頸部原発胎児型横紋筋肉腫の一例

小谷松 紗弓, 玉手 雅人, 篠原 由梨, 西村 庸子, 磯山 響子, 秋元 太志, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  74 ( 臨増 ) S - 297  2022年02月

子宮頸部原発胎児型横紋筋肉腫の一例

小谷松 紗弓, 玉手 雅人, 篠原 由梨, 西村 庸子, 磯山 響子, 秋元 太志, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  74 ( 臨増 ) S - 297  2022年02月

当院における妊孕性温存手術後の癒着因子の抽出とアウトカム

和田 渚, 玉手 雅人, 木島 紗弓, 篠原 由梨, 西村 庸子, 磯山 響子, 秋元 太志, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  74 ( 臨増 ) S - 344  2022年02月

Comparative Evaluation of Preoperative Imaging and Postoperative Histopathology in 108 Patients Who Underwent Laparoscopic- or Robot-Assisted Surgery for Endometrial Cancer.

Noriko Terada, Motoki Matsuura, Shoko Kurokawa, Mizue Teramoto, Masamitsu Hanakenaka, Tsuyoshi Saito

Gynecology and minimally invasive therapy   11 ( 4 ) 203 - 208  2022年  [国際誌]

　概要を見る

OBJECTIVES: The aim of this study was to compare preoperative imaging evaluation results and postoperative histopathology examinations of patients who underwent laparoscopic- or robot-assisted surgery for suspected Stage IA endometrial carcinoma. MATERIALS AND METHODS: There were 298 patients diagnosed with endometrial cancer at our institution between April 2014 and March 2019. Preoperative imaging evaluation based on magnetic resonance imaging (MRI) and computed tomography (CT) revealed 180 patients suspected of having Stage IA disease. Of these, 72 underwent open surgery, 12 underwent robot-assisted surgery, and 96 underwent laparoscopic surgery. In this study, preoperative imaging evaluation results and postoperative histopathology examinations of 108 patients who underwent laparoscopic- or robot-assisted surgery were retrospectively compared. RESULTS: Of the 108 patients, who underwent laparoscopic- or robot-assisted surgery for suspected Stage IA disease, 98 had Stage IA, two had Stage IB, and four had Stages II and III disease. The sensitivity of imaging evaluations based on preoperative MRI and CT was 90.7%. CONCLUSION: Utilizing preoperative MRI and CT imaging resulted in a high rate of successful diagnosis of Stage IA endometrial carcinoma.

DOI PubMed

Case of superficial myofibroblastoma protruding from the posterior fornix treated using laparoscopic surgery

Satoshi Shikanai, Motoki Matsuura, Hiroaki Soyama, Nagisa Wada, Mina Umemoto, Ichiro Miura, Tsuyoshi Saito

JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY ( Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy )  38 ( 2 ) 230 - 234  2022年

DOI

後腟円蓋より発生する腟腫瘍に対し腹腔鏡下手術を行い、表在性筋線維芽細胞腫と判明した1例

鹿内 智史, 松浦 基樹, 曽山 浩明, 和田 渚, 梅本 美菜, 三浦 一郎, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  38 ( 2 ) 230 - 234  2022年

　概要を見る

症例は43歳(0妊0産)で、過多月経と外陰部腫瘤を主訴とした。腫瘍は腟鏡診では後腟円蓋より外向性に発育し表面平滑で、各種画像、子宮頸部擦過診所見より、良性の腟壁由来の間葉系腫瘍、多発子宮筋腫を疑った。腹腔鏡下子宮全摘出術および腟腫瘍摘出術を行い、病理組織学的所見より表在性筋線維芽細胞腫と診断した。

The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma.

Hiroshi Shimada, Takayuki Kohno, Takumi Konno, Tadahi Okada, Kimihito Saito, Yuma Shindo, Shin Kikuchi, Mitsuhiro Tsujiwaki, Marie Ogawa, Motoki Matsuura, Tsuyoshi Saito, Takashi Kojima

Cancers   13 ( 24 )  2021年12月  [国際誌]

　概要を見る

Tight junction proteins play roles beyond permeability barriers functions and control cell proliferation and differentiation. The relation between tight junctions and the signal transduction pathways affects cell growth, invasion and migration. Abnormality of tight junction proteins closely contributes to epithelial mesenchymal transition (EMT) and malignancy of various cancers. Angulin-1/lipolysis-stimulated lipoprotein receptor (LSR) forms tricellular contacts that has a barrier function. Downregulation of angulin-1/LSR correlates with the malignancy in various cancers, including endometrioid-endometrial carcinoma (EEC). These alterations have been shown to link to not only multiple signaling pathways such as Hippo/YAP, HDAC, AMPK, but also cell metabolism in ECC cell line Sawano. Moreover, loss of angulin-1/LSR upregulates claudin-1, and loss of apoptosis stimulating p53 protein 2 (ASPP2) downregulates angulin-1/LSR. Angulin-1/LSR and ASPP2 concentrate at both midbody and centrosome in cytokinesis. In EEC tissues, angulin-1/LSR and ASPP2 are reduced and claudin-2 is overexpressed during malignancy, while in the tissues of endometriosis changes in localization of angulin-1/LSR and claudin-2 are seen. This review highlights how downregulation of angulin-1/LSR promotes development of endometriosis and EEC and discusses about the roles of angulin-1/LSR and its related proteins, including claudins and ASPP2.

DOI PubMed

Radical Vaginal Trachelectomy.

Tsuyoshi Saito, Motoki Matsuura, Masato Tamate, Masahiro Iwasaki, Tasuku Mariya

Surgery journal (New York, N.Y.)   7 ( Suppl 2 ) S103-S107  2021年12月  [国際誌]

　概要を見る

Recently, radical vaginal hysterectomy (RVH) has developed into laparoscopically assisted radical vaginal hysterectomy (LARVH), which is associated with the laparoscopical procedure, and it is applied as radical vaginal trachelectomy and semi-radical vaginal hysterectomy. LARVH is indicated for patients with stage IB1 and IIA1 cervical carcinoma, especially those with a tumor size of less than 2 cm, because the cardinal ligaments cannot be resected widely. Although RVH that is associated with laparoscopic pelvic lymphadenectomy is the most used surgical procedure, radical trachelectomy may be performed either abdominally or vaginally (laparoscopic or robotic). One report found that the pregnancy rate was higher in patients who underwent minimally invasive or radical vaginal trachelectomy than in those who underwent radical abdominal trachelectomy.

DOI PubMed

子宮頸がんに対する鏡視下広汎子宮全摘術の現状と課題-LACC studyから2年- 鏡視下広汎子宮全摘術の一隅を照らすCST教育

玉手 雅人, 松浦 基樹, 西村 庸子, 常松 梨紗, 幅田 周太朗, 金尾 祐之, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  26 ( 7 ) WS9 - 7  2021年12月

低侵襲手術時代における子宮体癌に対するリンパ節摘出の意義と方法 早期子宮体癌に対するリンパ節郭清の意義と術式の選択

松浦 基樹, 玉手 雅人, 長尾 沙智子, 西村 庸子, 秋元 太志, 幅田 周太朗, 寺田 倫子, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  26 ( 7 ) WS10 - 2  2021年12月

妊娠女性の頸部細胞診 妊娠中施行radical trachelectomy症例における妊娠中細胞診の変化

石岡 伸一, 新開 翔太, 真里谷 奨, 玉手 雅人, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.2 ) 458 - 458  2021年10月

骨髄間葉系間質細胞は子宮内膜症の病態に関与しているか?

幅田 周太朗, 玉手 雅人, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.2 ) 563 - 563  2021年10月

子宮頸癌根治照射症例におけるCD8の浸潤形式と予後との関連

染谷 正則, 土屋 高旭, 福島 悠希, 長谷川 智一, 北川 未央, 後町 俊夫, 岩崎 雅宏, 松浦 基樹, 齋藤 豪, 坂田 耕一

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  59回   O37 - 7  2021年10月

Prediction of treatment response from the microenvironment of tumor immunity in cervical cancer patients treated with chemoradiotherapy.

Masanori Someya, Takaaki Tsuchiya, Yuki Fukushima, Tomokazu Hasegawa, Masakazu Hori, Mio Kitagawa, Toshio Gocho, Shoh Mafune, Yutaro Ikeuchi, Yoshihiko Hirohashi, Toshihiko Torigoe, Masahiro Iwasaki, Motoki Matsuura, Tsuyoshi Saito, Yoshihisa Matsumoto, Koh-Ichi Sakata

Medical molecular morphology   54 ( 3 ) 245 - 252  2021年09月  [国内誌]

　概要を見る

To supplement clinical decision-making in the management of cervical cancer, various prognostic factors, including tumor immune microenvironments, were examined in patients with cervical cancer treated with definitive chemoradiotherapy. We retrospectively analyzed the expression of CD8, FoxP3, HLA-1, PD-L1, and XRCC4 in 100 cases of cervical cancer. The observed tumor immune microenvironments were also classified into three types: inflamed, excluded, and cold type. Less FoxP3+ T cells and cold-type tumor were found to be poor prognostic factors in addition to non-SCC, large pre-treatment tumor volume, and three or less cycles of concurrent chemotherapy based on multivariate analysis. Cold-type tumors had significantly worse prognoses than the other two types, whereas inflamed- and excluded-type tumors showed similar 5-year disease-specific survival (P < 0.001; 0% vs. 60.3% vs. 72.3%). Radiotherapy could overcome the inhibitory immune microenvironment that occurs in excluded type. Individualized combination therapy adapted to pre-treatment tumor immunity may be necessary to improve radiotherapy outcomes in cervical cancer.

DOI PubMed

後腟円蓋より突出する腟腫瘍に対し腹腔鏡下手術を行い、表在性筋線維芽細胞腫と判明した1例

鹿内 智史, 松浦 基樹, 梅本 美菜, 杉田 奈穂子, 鈴木 将裕, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  37 ( Suppl.I ) 376 - 376  2021年09月

腹腔鏡下に治療し得た非交通性副角妊娠の一例

和田 渚, 春日 芙貴子, 磯山 響子, 常松 梨紗, 玉手 雅人, 幅田 周太朗, 寺田 倫子, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  37 ( Suppl.I ) 225 - 225  2021年09月

異所性妊娠破裂による出血性ショックに対して、REBOAを施行し、安全に腹腔鏡下手術をなしえた1例

岩崎 雅宏, 古来 愛香, 幅田 周太朗, 池田 桂子, 野藤 五沙, 野呂 薫, 玉手 雅人, 松浦 基樹, 秋元 太志, 磯山 響子, 西村 庸子, 和田 渚, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  37 ( Suppl.I ) 309 - 309  2021年09月

肉腫成分過剰増殖を伴う子宮腺肉腫の一例

和田 渚, 幅田 周太朗, 安宅 真名美, 野呂 薫, 柏木 葉月, 野藤 五沙, 玉手 雅人, 真里谷 奨, 池田 桂子, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  68回   60 - 60  2021年08月

Bevacizumab併用PTX療法が奏功したBevacizumab併用化学療法既往のある再発子宮頸部腺癌の1例

西森 貢隆, 嶋田 浩志, 杉山 芽, 藤部 佑哉, 鈴木 美紀, 玉手 雅人, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  68回   59 - 59  2021年08月

帝王切開瘢痕部妊娠に対して一期的修復術を施行した一例

齋藤 晋平, 玉手 雅人, 有元 千紘, 長尾 沙智子, 山崎 智子, 西村 庸子, 磯山 響子, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  68回   57 - 57  2021年08月

分娩後の子宮全摘出術時に発見され、腹膜癌との鑑別が困難であった異所性脱落膜の1例

有元 千紘, 長尾 沙智子, 堀 清貴, 山崎 智子, 玉手 雅人, 高田 さくら, 松浦 基樹, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  68回   73 - 73  2021年08月

最終摘出から16年後に再発した卵巣癌ポート部位転移の1例

杉山 芽, 嶋田 浩志, 西森 貢隆, 藤部 佑哉, 鈴木 美紀, 玉手 雅人, 松浦 基樹, 岩崎 雅宏, 斎藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  68回   65 - 65  2021年08月

待機療法にて管理したHypervascular RPOCの3例

堀 清貴, 山崎 智子, 有元 千紘, 長尾 沙智子, 玉手 雅人, 高田 さくら, 松浦 基樹, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  68回   46 - 46  2021年08月

子宮温存している若年発症子宮体部腺肉腫の2例

寺田 倫子, 松浦 基樹, 野藤 五沙, 西村 庸子, 真里谷 奨, 玉手 雅人, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   292 - 292  2021年07月

消化管ポリープ切除技術を応用した子宮頸部円錐切除術とコストの検討

玉手 雅人, 松浦 基樹, 西村 庸子, 寺田 倫子, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   330 - 330  2021年07月

術前補助化学療法後の子宮頸癌再発に対しheterogeneousな免疫逃避機構が関与している可能性 症例報告(Heterogenous Immune Escape Mechanisms Might be Related to Recurrence of Cervical Cancer after the Neoadjuvant Chemotherapy: A Case Report)

常松 梨紗, 岩崎 雅宏, 廣橋 良彦, 阿部 秀悦, 小川 万梨絵, 郷久 晴朗, 西村 庸子, 玉手 雅人, 磯山 響子, 寺田 倫子, 松浦 基樹, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   320 - 320  2021年07月

自己採取および尿採取HPV検査の有効性に関する検討

松浦 基樹, 寺田 倫子, 西村 庸子, 玉手 雅人, 磯山 響子, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   326 - 326  2021年07月

子宮温存している若年発症子宮体部腺肉腫の2例

寺田 倫子, 松浦 基樹, 野藤 五沙, 西村 庸子, 真里谷 奨, 玉手 雅人, 岩崎 雅宏, 齋藤 豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   292 - 292  2021年07月

子宮頸部通常型内頸部腺癌IB2-IIB期に対する術前化学療法の有用性

千葉 淳美, 島田 宗昭, 的田 眞紀, 竹原 和宏, 菊池 朗, 高野 浩邦, 角 俊幸, 朴 鐘明, 鈴木 一弘, 氏平 崇文, 松浦 基樹, 宮城 悦子, 大原 樹, 池田 仁惠, 森重 健一郎, 秋山 梓, 濱西 潤三, 笹島 ゆう子, 武隈 宗孝, 榎本 隆之

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 )  63回   334 - 334  2021年07月

多様化する手術教育の実践 がんの手術をどう学び、どう伝えるか

松浦 基樹, 玉手 雅人, 西村 庸子, 寺田 倫子, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 32 ) 43 - 46  2021年06月

Estimation of Physiologic Ability and Surgical Stress(E-PASS)で評価した後期高齢者の婦人科手術

篠原 由梨, 玉手 雅人, 岡田 匡氷, 春日 芙貴子, 阿部 秀悦, 伊野 善彦, 寺田 倫子, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 32 ) 152 - 152  2021年06月

手術室の医療安全を考える サージカルスモークについて

西尾 空, 玉手 雅人, 松浦 基樹, 寺田 倫子, 磯山 響子, 春日 芙貴子, 岡田 匡氷, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 32 ) 153 - 153  2021年06月

帝王切開術後癒着症例に対する腹腔鏡下子宮全摘術での膀胱剥離の工夫

有元 千紘, 長尾 沙智子, 山崎 智子, 高田 さくら, 玉手 雅人, 恐神 博行, 松浦 基樹, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 32 ) 138 - 138  2021年06月

多様化する子宮全摘 腟式子宮全摘の視点 全アプローチを経験して振り返った腟式

玉手 雅人, 松浦 基樹, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 32 ) 13 - 19  2021年06月

体腔液セルブロックによる免疫染色の検討

玉手 雅人, 松浦 基樹, 西村 庸子, 新開 翔太, 真里谷 奨, 寺田 倫子, 岩崎 雅宏, 石岡 伸一, 杉田 真太朗, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.1 ) 189 - 189  2021年05月

進行卵巣癌における腹水細胞診と腹水遺伝子診断

松浦 基樹, 西村 庸子, 玉手 雅人, 寺田 倫子, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.1 ) 269 - 269  2021年05月

医師採取HPV検査と自己採取および尿採取法によるHPV検査の比較研究

寺田 倫子, 松浦 基樹, 西村 庸子, 玉手 雅人, 長尾 沙智子, 田渕 雄大, 寺本 瑞絵, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  60 ( Suppl.1 ) 228 - 228  2021年05月

Phase 2 single-arm study on the efficacy and safety of niraparib in Japanese patients with heavily pretreated, homologous recombination-deficient ovarian cancer.

Aikou Okamoto, Eiji Kondo, Toshiaki Nakamura, Satoshi Yanagida, Junzo Hamanishi, Kenichi Harano, Kosei Hasegawa, Takeshi Hirasawa, Kensuke Hori, Shinichi Komiyama, Motoki Matsuura, Hidekatsu Nakai, Hiroko Nakamura, Jun Sakata, Tsutomu Tabata, Kazuhiro Takehara, Munetaka Takekuma, Yoshihito Yokoyama, Yoichi Kase, Shuuji Sumino, Junpei Soeda, Ajit Suri, Daisuke Aoki, Toru Sugiyama

Journal of gynecologic oncology   32 ( 2 ) e16  2021年03月  [国際誌]

　概要を見る

OBJECTIVE: To evaluate the efficacy and safety of niraparib in Japanese women with heavily pretreated ovarian cancer. METHODS: This Phase 2 open-label, single-arm study enrolled Japanese women with homologous recombination deficiency-positive relapsed, high-grade serous ovarian, fallopian tube, or primary peritoneal cancer who had completed 3-4 lines of therapy. The starting dose of niraparib was 300 mg administered once daily in continuous 28-day cycles until objective progressive disease, unacceptable toxicity, consent withdrawal or discontinuation. The primary endpoint, objective response rate (ORR), was assessed by the investigator using RECIST version 1.1. Safety evaluations included the incidence of treatment-emergent adverse events (TEAEs), including serious TEAEs. RESULTS: Twenty women were enrolled and the confirmed ORR in the full analysis set (FAS) was 35.0% (7/20), consisting of 1 complete response and 6 partial responses. Disease control rate in the FAS was 90.0%. The most frequently reported TEAEs (>50%) were anemia, nausea, and platelet count decreased. One patient (5.0%) had TEAEs leading to discontinuation of niraparib whereas reductions or interruptions were reported in 14 (70.0%) and 15 (75.0%) patients, respectively. The median dose intensity (202.9 mg daily) corresponded to a relative dose intensity of 67.6%. CONCLUSION: Efficacy and safety of niraparib in heavily pretreated Japanese women was comparable to that seen in an equivalent population of non-Japanese women. No new safety signals were identified. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03759600.

DOI PubMed

病院全体の医療安全を考える サージカルスモークについて

西尾 空, 玉手 雅人, 松浦 基樹, 寺田 倫子, 磯山 響子, 春日 芙貴子, 岡田 匡氷, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  73 ( 臨増 ) S - 297  2021年03月

術前化学療法が奏功し手術療法が可能となった子宮頸癌IV期病変の摘出子宮における腫瘍浸潤リンパ球(TIL)の特徴を検証した1例

常松 梨紗, 岩崎 雅宏, 郷久 晴朗, 阿部 秀悦, 小川 万梨絵, 黒川 晶子, 西村 庸子, 玉手 雅人, 磯山 響子, 寺田 倫子, 松浦 基樹, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  73 ( 臨増 ) S - 313  2021年03月

子宮体がんスクリーニングにおける遺伝子解析併用の有用性

松浦 基樹, 玉手 雅人, 西尾 空, 西村 庸子, 磯山 響子, 寺田 倫子, 岩崎 雅宏, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  73 ( 臨増 ) S - 400  2021年03月

胃原発転移性卵巣腫瘍に対し付属器摘出術を施行した症例の検討

田中 綾一, 辻 靖, 南 妃奈, 清水 亜由美, 池田 詩子, 逸見 博文, 神 崇志, 新藤 智子, 鈴木 善法, 玉手 雅人, 松浦 基樹, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  65 ( 1 ) 43 - 48  2021年03月

　概要を見る

転移性卵巣腫瘍は胃癌または大腸癌からの転移が最も多い。胃癌からの転移性卵巣腫瘍は周囲臓器へ浸潤または癒着を認める症例は比較的少なく低侵襲に摘出可能であることが多い。胃原発転移性卵巣腫瘍に対し付属器摘出術を施行した症例について検討した。対象は2017年から2年間の間に胃癌を原発とした転移性卵巣腫瘍に対し付属器摘出術を施行した6例。周術期合併症,術後化学療法開始までの期間,無増悪期間,生存期間,術前術後のQOLの変化等について検討した。胃癌診断時の年齢の中央値は47.0歳,6例中5例に腹腔鏡下手術を選択し,周術期合併症を認めた症例は無かった。術前に下腹部痛を認めた2例は共に術後の症状の消失が確認できた。化学療法再開までの中央値は18.0日,増悪または再発をみとめた3例の無増悪期間はそれぞれ8,2,8ヵ月,付属器摘出術後12,8,12ヵ月に原病死に至った。他の3例は現在いずれも無病生存している。症状緩和目的または卵巣転移以外の病勢が充分に制御されている症例において胃原発転移性卵巣腫瘍に対する付属器摘出術は検討され得ると考えられた。(著者抄録)

Cadaver Surgery Trainingの壁と意義

玉手 雅人, 松浦 基樹, 西尾 空, 太田 未咲, 佐藤 由梨, 野呂 薫, 長尾 沙智子, 阿部 秀悦, 西村 庸子, 磯山 響子, 寺田 倫子, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  65 ( 1 ) 88 - 89  2021年03月

Study of laparoscopic monopolar devices and its thermal effects

Motoki Matsuura, Masato Tamate, Sachiko Nagao, Muna Nishio, Tadahi Okada, Yoko Nishimura, Kyoko Isoyama, Noriko Terada, Tsuyoshi Saito

European Journal of Gynaecological Oncology ( IMR Press Limited )  42 ( 1 ) 118 - 121  2021年02月

　概要を見る

Objective: Energy devices are frequently used in minimally invasive surgeries (MIS). For MIS involving gynecologic malignancies, energy devices should be used cautiously to prevent thermal injuries to nearby organs. We evaluated monopolar electrosurgery devices and measured increases in temperature in the tissue and device. Methods: Briefly, the surface of a porcine tissue was incised using short and long activation times. Subsequently, the maximum temperature at the tip of the monopolar device, the cooling time required to reach a temperature of 60 ◦C, and the maximum tissue temperature were recorded. Results: Longer activation time was correlated with a higher tip temperature. With all activation times, there was an increase in the tip temperature that exceeded 100 ◦C. The cooling time to reach 60 ◦C was faster with the short activation times than with the long activation times. Even with the same output, the temperature decreased faster in the coagulation mode, suggesting that the cooling times were shorter with lower outputs. The tissue temperature dropped to 60 ◦C or less within 1 s in the cut mode but required approximately 2 s in the coagulation mode at 40 W. The temperature of the dissected tissue increased to 60 ◦C or higher the cooling time was longer with high output and in the coagulation mode. Conclusions: We revealed that the activation of the monopolar device under routine use conditions exceeded a temperature of 100 ◦C. Additionally, the temperatures of the tip and tissue were significantly higher in proportion to the output and time. For MIS involving gynecologic malignancies, careful attention is necessary to avoid thermal injury.

DOI

骨盤解剖学をCadaver Surgery Trainingで理解する混合研究の試み

玉手 雅人, 松浦 基樹, 阿部 秀悦, 西村 庸子, 常松 梨沙, 寺田 倫子, 真里谷 奨, 岩崎 雅宏, 金尾 祐之, 齋藤 豪

日本婦人科腫瘍学会雑誌 ( (公社)日本婦人科腫瘍学会 )  39 ( 1 ) 311 - 311  2021年01月

ERα increases endometrial cancer cell resistance to cisplatin via upregulation of BAG3.

Shuetsu Abe, Masahiro Iwasaki, Shutaro Habata, Tasuku Mariya, Masato Tamate, Motoki Matsuura, Seiro Satohisa, Tsuyoshi Saito

Oncology letters   21 ( 1 ) 20 - 20  2021年01月  [国際誌]

　概要を見る

Endometrial cancer is a leading cause of cancer-associated mortality in women and has a poor prognosis in advanced stages. Our previous study revealed that BCL-2-associated athanogene 3 (BAG3) may contribute to enhancing cell viability through downregulation of microRNA (miR)-29b in endometrial cancer cell lines. In addition, a relationship between estrogen receptor α (ERα) and BAG3 was recently reported in several cancer cell types. The present study investigated the relationship between ERα and BAG3 in endometrial cancer cell lines. The results demonstrated that exogenous ERα overexpression enhanced BAG3 expression in the EMTOKA endometrial cancer cell line, which does not endogenously express ERα, but had no effect on BAG3 expression levels in the Ishikawa cell line, which does endogenously express ERα. In addition, ERα overexpression suppressed miR-29b expression and enhanced the expression of Mcl-1, a mediator situated downstream of BAG3, in EMTOKA cells, but not Ishikawa cells. ERα overexpression also enhanced EMTOKA, but not Ishikawa, endometrial cancer cell viability in the presence of cisplatin. These findings suggested that ERα may contribute to enhancing endometrial cancer cell resistance to anticancer agents through BAG3 overexpression.

DOI PubMed

Deep Learning(YOLOv3)を用いたリアルタイム婦人科細胞診断支援システム設計の試み

真里谷 奨, 新開 翔太, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 南部 優太, 藤野 雄一, 淺沼 広子, 廣橋 良彦, 鳥越 俊彦, 齋藤 豪

日本婦人科腫瘍学会雑誌 ( (公社)日本婦人科腫瘍学会 )  39 ( 1 ) 278 - 278  2021年01月

骨盤解剖学をCadaver Surgery Trainingで理解する混合研究の試み

玉手 雅人, 松浦 基樹, 阿部 秀悦, 西村 庸子, 常松 梨沙, 寺田 倫子, 真里谷 奨, 岩崎 雅宏, 金尾 祐之, 齋藤 豪

日本婦人科腫瘍学会雑誌 ( (公社)日本婦人科腫瘍学会 )  39 ( 1 ) 311 - 311  2021年01月

Deep Learning(YOLOv3)を用いたリアルタイム婦人科細胞診断支援システム設計の試み

真里谷 奨, 新開 翔太, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 南部 優太, 藤野 雄一, 淺沼 広子, 廣橋 良彦, 鳥越 俊彦, 齋藤 豪

日本婦人科腫瘍学会雑誌 ( (公社)日本婦人科腫瘍学会 )  39 ( 1 ) 278 - 278  2021年01月

タイト結合分子Cluadin-2をターゲットにした子宮内膜癌治療のin vitroにおける検討

嶋田 浩志, 岡田 匡氷, 金野 匠, 幸野 貴之, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 小島 隆, 齋藤 豪

日本婦人科腫瘍学会雑誌 ( (公社)日本婦人科腫瘍学会 )  39 ( 1 ) 285 - 285  2021年01月

Phase 2 single-arm study on the safety of maintenance niraparib in Japanese patients with platinum-sensitive relapsed ovarian cancer

Kazuhiro Takehara, Takashi Matsumoto, Junzo Hamanishi, Kosei Hasegawa, Motoki Matsuura, Kiyonori Miura, Shoji Nagao, Hidekatsu Nakai, Naotake Tanaka, Hideki Tokunaga, Kimio Ushijima, Hidemichi Watari, Yoshihito Yokoyama, Yoichi Kase, Shuuji Sumino, Ajit Suri, Hiroaki Itamochi, Nobuhiro Takeshima

Journal of Gynecologic Oncology ( Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology and Colposcopy )  32  2021年

DOI

Updated results of a phase 2 study of niraparib in heavily pretreated high-grade serous ovarian cancer patients in Japan

Motoki Matsuura

Annals of Oncology    2021年

DOI

腹腔鏡下子宮筋腫核出術後に発生したparasitic myomaの1例

岩崎 雅宏, 真里谷 奨, 阿部 秀悦, 松浦 基樹, 玉手 雅人, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  36 ( Suppl.I ) [O - 196]  2020年11月

若手医師が腹腔鏡手術教育を考える(若手医師ならではの斬新なアイデアを募る) 地区を越えて、お互いの頑張りを"見える化"する! 北海道/東北合同若手腹腔鏡縫合セミナー

田村 良介, 水沼 槙人, 高尾 航, 小澤 梨紗子, 黒須 博之, 長尾 沙智子, 西村 庸子, 玉手 雅人, 松浦 基樹, 竹中 慎, 林 茂徳

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  36 ( Suppl.I ) [WS2 - 5]  2020年11月

若手医師に対する腹腔鏡手術の教育 原点回帰、Cadaver Surgery Trainingを用いた教育

玉手 雅人, 松浦 基樹, 篠原 由梨, 黒川 晶子, 西村 庸子, 磯山 響子, 寺田 倫子, 金尾 祐之, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  36 ( Suppl.I ) [SY1 - 4]  2020年11月

腹腔鏡下子宮全摘出術施行時に偶発的に副脾を認めた一例

長尾 沙智子, 有元 千紘, 山崎 智子, 玉手 雅人, 恐神 博行, 高田 さくら, 松浦 基樹, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  36 ( Suppl.I ) [O - 046]  2020年11月

腹腔鏡下子宮筋腫核出術後に発生したparasitic myomaの1例

岩崎 雅宏, 真里谷 奨, 阿部 秀悦, 松浦 基樹, 玉手 雅人, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  36 ( Suppl.I ) [O - 196]  2020年11月

根治放射線療を行った進行期子宮頸癌症例における腫瘍免疫と予後の関連

染谷 正則, 土屋 高旭, 福島 悠希, 長谷川 智一, 高田 優, 中田 健生, 堀 正和, 三浦 勝利, 北川 未央, 後町 俊夫, 岩崎 雅宏, 松浦 基樹, 齋藤 豪, 坂田 耕一

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  58回   O16 - 4  2020年10月

Association between cancer immunity and treatment results in uterine cervical cancer patients treated with radiotherapy

Masanori Someya, Takaaki Tsuchiya, Yuki Fukushima, Tomokazu Hasegawa, Yu Takada, Masakazu Hori, Katsutoshi Miura, Mio Kitagawa, Toshio Gocho, Yoshihiko Hirohashi, Toshihiko Torigoe, Masahiro Iwasaki, Motoki Matsuura, Tsuyoshi Saito, Koh-ichi Sakata

Japanese Journal of Clinical Oncology ( Oxford University Press (OUP) )   2020年08月

　概要を見る

To evaluate proteins related to tumor immune response and treatment outcome from radiotherapy for uterine cervical cancer patients. We performed a retrospective immunohistochemical staining of 81 patients with uterine cervical cancer who underwent definitive radiotherapy. We examined the expression of programmed death ligand 1, human leukocyte antigen class I, tumor-infiltrating CD8+, and forkhead box P3+ (FoxP3+) T cells in tumor tissues. In biopsy specimen, patients with a higher number of CD8+ T cells and FoxP3+ T cells had a better disease-specific survival than patients with a lower number of CD8+ T cells and FoxP3+ cells (P = 0.018 and P = 0.009). Multivariate analysis showed that equivalent dose in 2 Gy fractions (EQD2) of the minimum dose to 90% of the high-risk clinical target volume, FoxP3+ T cells and expression of human leukocyte antigen class I were significant prognostic factors. When the EQD2 is 70 Gy or more, a higher local control rate is obtained regardless of the number of CD8- or FoxP3-positive cells. When EQD2 is &lt;70 Gy, the number of CD8-positive cells has a significant impact on treatment outcome: the recurrence rate (local recurrence rate + distant metastasis rate) was 46.2% in the group with a CD8 value of 230 or higher, whereas the recurrence rate was 75.7% in the group with a CD8 value of less than 230. The combination of CD8 or FoxP3 with EQD2 can be potentially useful to predict the treatment results of radiotherapy for cervical cancer, leading to individualized optimal selection of treatment for cervical cancer.

DOI

Cadaver Surgery Trainingの壁を超える意義

玉手 雅人, 松浦 基樹, 西村 庸子, 真里谷 奨, 磯山 響子, 寺田 倫子, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 31 ) 189 - 189  2020年08月

ロボット手術におけるPeNのコツ

松浦 基樹, 西村 庸子, 黒川 晶子, 玉手 雅人, 磯山 響子, 寺田 倫子, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 31 ) 155 - 155  2020年08月

Mucinous carcinoma originating in the peritoneum diagnosed by an ascites cell block: a case report.

Sachiko Nagao, Motoki Matsuura, Masato Tamate, Shintaro Sugita, Tsuyoshi Saito

Journal of medical case reports   14 ( 1 ) 99 - 99  2020年07月  [国際誌]

　概要を見る

BACKGROUND: Peritoneal carcinoma is a rare disease that is diagnosed and treated in a manner similar to ovarian cancer. In most cases, the histological type is serous carcinoma, and chemotherapy is effective. However, there are a few case reports of mucinous peritoneal carcinoma. We inferred the histological type before surgery using an ascites cell block sample, which was useful for determining the treatment plan. CASE PRESENTATION: Our patient was a 60-year-old Japanese woman. She presented with a feeling of fullness in the abdomen. A computed tomographic scan showed a large quantity of ascitic fluid and thickening of the greater omentum, as well as thickening of the peritoneum at the pouch of Douglas and diaphragm. Hence, peritoneal carcinoma was suspected. The tumor markers carcinoembryonic antigen, cancer antigen 19-9, and cancer antigen 125 were all increased, and no malignant findings were observed in the uterus or ovaries. Cells suggestive of carcinoma were found in the ascitic fluid, and immunostaining by the cell block method suggested the possibility of mucinous carcinoma. The preoperative chemotherapy strategy was changed to short courses, and tumor reduction surgery was planned. Similar to the suspicion before surgery, the pathology results indicated mucinous carcinoma, and the therapeutic effect of chemotherapy was grade 0. CONCLUSIONS: Determining whether peritoneal carcinoma is serous carcinoma is important for therapy and prognostic prediction. In this case, we encountered a patient for whom surgery was chosen because of drug therapy resistance inferred through histological type estimation using the cell block method. Inferring the histological type by cell block preparation is useful for diagnosis and treatment selection.

DOI PubMed

早期子宮体癌における腹腔細胞診に関する検討

西村 庸子, 松浦 基樹, 玉手 雅人, 寺田 倫子, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  59 ( 3 ) 125 - 128  2020年05月

　概要を見る

目的:子宮体癌における腹腔細胞診の結果は2008年のFIGO分類において進行期の決定に考慮されなくなった。独立した予後因子になるとするいくつかの報告もあるが、現在のところ腹腔細胞診と予後との関係については、結論が得られていない。今回われわれは、術前1A期の診断で腹腔鏡下手術を行い、術後病理でも1Aと診断された症例の腹腔細胞診に関して検討した。方法:2014年7月〜2018年12月に術前1A期の診断で腹腔鏡下子宮全摘、両側付属器摘出術(症例によっては骨盤リンパ節郭清)を行った82例について検討した。成績:82例のうち、5例(6.1%)は腹腔細胞診が陽性であった。5例のうち、1例は脈管侵襲陽性であり、4例は脈管侵襲陰性で、その他のリスク因子も認めなかった。5例のうち、2例は術後化学療法が行われ、いずれも再発はみられていないが、術後化学療法を行わなかった3例はいずれも再発を認めた。腹腔細胞診が陰性であった77例の中で再発をきたした症例は2例あり、1例は肺転移、もう1例は腹膜播種再発であった。結論:今回の結果はフォローアップ期間も、症例数も限定的なものではあるが、低リスク子宮体癌であっても腹腔細胞診陽性であれば術後補助療法を施行した方が予後が改善する可能性が示唆された。(著者抄録)

妊娠中の広汎子宮頸部全摘出術 腟式トラケレクトミー

齋藤 豪, 岩崎 雅宏, 松浦 基樹, 玉手 雅人, 真里谷 奨, 石岡 伸一

日本婦人科腫瘍学会雑誌 ( (公社)日本婦人科腫瘍学会 )  38 ( 2 ) 145 - 150  2020年04月

　概要を見る

われわれの教室では従来腟式準広汎性子宮全摘術に取り組んでいたが、平成16年より本術式を応用し腟式トラケレクトミーに取り組んでいる。これまで79例の腟式トラケレクトミーを行ってきたが、このうち2010年以来7例に対し妊娠初期の子宮頸がんに対し本術式を行う機会があったので報告する。症例は妊娠12週から26週で、6例がIB1期で、1例がIB2期であった。手術は腹式に骨盤リンパ郭清術を施行して、腟式に子宮頸部の操作を行い、最終的に子宮動脈本幹起始部レベルで子宮頸部を切断する。その後、頸部をナイロン糸でマクドナルド縫合し腟壁と縫合した。本術式の適応に関する基本方針は腫瘍径2cm以下のIB1期までとしているが、患者の希望が極めて強くリスクを説明してもなお妊娠の継続を望む症例に関して、7例中2例に関してはそれ以上の症例で手術を施行した。IB2期の症例は骨盤リンパ転移を認め、16週で妊娠を中断し子宮全摘・CCRTを施行した。他の1例はリンパ転移を認めたが、妊娠継続の希望が強く、再発リスクを説明した上で妊娠中に化学療法を施行し30週で妊娠を中断、子宮全摘・CCRTを施行した。その他の5例はリンパ転移を認めずtermで帝王切開術にて分娩している。今回の7例すべての症例において再発は認めておらず、破水などの産科合併症も認められなかった。今回の検討で6例の生児を得たが、児には発達の障害は認められていない。これまでの経験を通じ、妊娠中のリンパ郭清および腟式トラケレクトミーに関しては、大きな合併症を引き起こすリスクはそれほど高くはないことが示唆された。しかし、症例の適応、手術の時期、その他の治療法の選択などについては検討の余地は多く、他施設での症例の蓄積が必要と考える。(著者抄録)

子宮頸がんにおける当院のVaginal Trachelectomyの成績と意義

玉手 雅人, 松浦 基樹, 黒川 晶子, 西村 庸子, 磯山 響子, 寺田 倫子, 真里谷 奨, 岩崎 雅宏, 石岡 伸一, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  72 ( 臨増 ) S - 359  2020年03月

子宮筋腫に対して腹腔鏡手術後,異型細胞・核分裂像の増加を認めた症例の特徴と傾向

神 未央奈, 玉手 雅人, 明石 祐史, 杉尾 明香, 足立 英文, 松浦 基樹, 森下 美幸, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  64 ( 1 ) 104 - 104  2020年03月

子宮体癌の化学療法後に治療関連骨髄異形成症候群を発症した1例

小川 万梨絵, 岩崎 雅宏, 阿部 秀悦, 常松 梨紗, 郷久 晴朗, 黒川 晶子, 西村 庸子, 玉手 雅人, 磯山 響子, 寺田 倫子, 松浦 基樹, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  72 ( 臨増 ) S - 592  2020年03月

当院における婦人科悪性腫瘍患者の血栓症治療に関する検討

西村 庸子, 松浦 基樹, 黒川 晶子, 玉手 雅人, 磯山 響子, 寺田 倫子, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  72 ( 臨増 ) S - 528  2020年03月

初回術前化学療法後に心肺停止となった卵巣癌の1例

常松 梨紗, 岩崎 雅宏, 野呂 薫, 阿部 秀悦, 小川 万梨絵, 郷久 晴朗, 西村 庸子, 玉手 雅人, 磯山 響子, 寺田 倫子, 松浦 基樹, 齋藤 豪

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  72 ( 臨増 ) S - 653  2020年03月

再発卵巣癌の維持療法に対するniraparibの国内単群試験 投与初期の安全性評価を中心に

松元 隆, 竹原 和宏, 竹島 信宏, 濱西 潤三, 長谷川 幸清, 松浦 基樹, 三浦 清徳, 長尾 昌二, 中井 英勝, 田中 尚武, 徳永 英樹, 牛嶋 公生, 渡利 英道, 横山 良仁, 加瀬 陽一, 角野 修司, Suri Ajit, 板持 広明, Niraparib-2001

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  72 ( 臨増 ) S - 398  2020年03月

複数の前治療歴を有する進行・再発卵巣癌に対するniraparib単剤の国内試験

田畑 務, 中村 俊昭, 柳田 聡, 濱西 潤三, 原野 謙一, 長谷川 幸清, 平澤 猛, 伊藤 公彦, 小宮山 慎一, 松浦 基樹, 中井 英勝, 中村 紘子, 坂田 純, 竹原 和宏, 武隈 宗孝, 横山 良仁, 加瀬 陽一, 角野 修司, 添田 純平, Suri Ajit, 杉山 徹, 青木 大輔, Niraparib-2002

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  72 ( 臨増 ) S - 398  2020年03月

再発卵巣癌の維持療法に対するniraparibの国内単群試験 投与初期の安全性評価を中心に

松元 隆, 竹原 和宏, 竹島 信宏, 濱西 潤三, 長谷川 幸清, 松浦 基樹, 三浦 清徳, 長尾 昌二, 中井 英勝, 田中 尚武, 徳永 英樹, 牛嶋 公生, 渡利 英道, 横山 良仁, 加瀬 陽一, 角野 修司, Suri Ajit, 板持 広明, Niraparib-2001

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 )  72 ( 臨増 ) S - 398  2020年03月

再発外陰癌に対する化学療法中に発症した間質性肺炎の1症例

斉藤 公仁, 郷久 晴朗, 岩崎 雅宏, 鹿内 智史, 秋元 太志, 石堂 茉泉, 西村 庸子, 玉手 雅人, 松浦 基樹, 寺本 瑞絵, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  64 ( 1 ) 100 - 100  2020年03月

若手産婦人科医の腹腔鏡手技トレーニングにおけるタイムトライアルの有用性の検討

長尾 沙智子, 玉手 雅人, 藤部 佑哉, 西村 庸子, 松浦 基樹, 寺本 瑞絵, 馬場 剛, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  64 ( 1 ) 102 - 102  2020年03月

アプローチを横断した子宮全摘術の教育

玉手 雅人, 松浦 基樹, 神 未央奈, 石堂 茉泉, 斉藤 公仁, 西村 庸子, 寺本 瑞絵, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  64 ( 1 ) 102 - 102  2020年03月

ロボット支援下手術におけるロールインからコンソールまでの定型化の必要性

西村 庸子, 松浦 基樹, 黒川 晶子, 玉手 雅人, 寺田 倫子, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  24 ( 7 ) MO323 - 5  2019年12月

モルセーフを円滑に挿入するための当科での工夫

寺田 倫子, 玉手 雅人, 西村 庸子, 松浦 基樹, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  24 ( 7 ) MO316 - 5  2019年12月

腹腔鏡手術修練におけるCadaver Surgical Trainingの有用性

黒川 晶子, 玉手 雅人, 長尾 沙智子, 西村 庸子, 寺田 倫子, 松浦 基樹, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  24 ( 7 ) MO212 - 6  2019年12月

円錐切除後断端陰性の子宮頸部高度異形成(CIN3)に対するTLH後に、SCCが判明した1例

常松 梨紗, 岡田 匡氷, 長尾 沙智子, 黒川 晶子, 西村 庸子, 玉手 雅人, 松浦 基樹, 森下 美幸, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  24 ( 7 ) MO318 - 3  2019年12月

早期子宮体癌に対する腹腔鏡下手術とロボット支援下手術の比較検討

松浦 基樹, 黒川 晶子, 西村 庸子, 玉手 雅人, 寺田 倫子, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  24 ( 7 ) MO324 - 5  2019年12月

転移性女性生殖器がんにおける臨床像と捺印細胞像

玉手 雅人, 松浦 基樹, 長尾 沙智子, 西村 庸子, 真里谷 奨, 寺田 倫子, 郷久 晴朗, 杉田 真太朗, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  58 ( Suppl.2 ) 601 - 601  2019年10月

当院におけるオラパリブ投与症例の検討

松浦 基樹, 黒川 晶子, 西村 庸子, 玉手 雅人, 磯山 響子, 寺田 倫子, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  57回   P156 - 7  2019年10月

術前診断が困難であった早期卵巣癌の一例

松浦 基樹, 西村 庸子, 玉手 雅人, 寺田 倫子, 寺本 瑞絵, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  58 ( Suppl.2 ) 602 - 602  2019年10月

当科において妊娠初期子宮頸部細胞診HSIL/ASC-H以上を認めた症例の検討

真里谷 奨, 石岡 伸一, 玉手 雅人, 郷久 晴朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  58 ( Suppl.2 ) 587 - 587  2019年10月

ロボット支援下手術におけるロールインからコンソールまでの定型化の必要性

西村 庸子, 松浦 基樹, 黒川 晶子, 玉手 雅人, 寺田 倫子, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  67回   74 - 74  2019年09月

若年女性に発症した外陰部Bowen病の一例

太田 未咲, 郷久 晴朗, 岩崎 雅宏, 小川 万梨絵, 常松 梨紗, 阿部 秀悦, 野呂 薫, 黒川 晶子, 西村 庸子, 玉手 雅人, 磯山 響子, 寺田 倫子, 松浦 基樹, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  67回   79 - 79  2019年09月

タイト結合による子宮内膜の悪性化制御機序

郷久 晴朗, 嶋田 浩志, 岩崎 雅宏, 染谷 真行, 金野 匠, 菊池 真, 幸野 貴之, 玉手 雅人, 松浦 基樹, 小島 隆, 齋藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  67回   36 - 36  2019年09月

ダイヤモンド法においてポート間隔が縫合結紮に及ぼす影響 ドライボックスでの検討

吉野 育典, 喜納 奈緒, 高尾 茉希, 青木 美帆子, 仙波 恵樹, 平賀 裕章, 長尾 沙智子, 吉泉 絵理, 遠山 篤史, 山本 さやか, 天雲 千晶, 友野 勝幸, 矢田 大輔, 角 暢浩, 玉手 雅人, 竹中 慎, 松浦 基樹, 林 茂徳, 金尾 祐之

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 121 - 121  2019年08月

疲れにくい腹腔鏡手術 男女の身体的特性から

長尾 沙智子, 西村 庸子, 玉手 雅人, 松浦 基樹, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 117 - 117  2019年08月

腹腔鏡下子宮体癌手術を行った95例の術前評価と術後病理組織診の比較検討

寺田 倫子, 松浦 基樹, 黒川 晶子, 西村 庸子, 玉手 雅人, 寺本 瑞絵, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 281 - 281  2019年08月

腹腔鏡下子宮筋腫核出術後に、ポート挿入部に腫瘍転移した1例

岩崎 雅宏, 郷久 晴朗, 小川 万梨絵, 阿部 秀悦, 松浦 基樹, 玉手 雅人, 西村 庸子, 常松 梨紗, 黒川 晶子, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 246 - 246  2019年08月

産婦人科卒後後期研修医としてCadaverで学べること

神 未央奈, 玉手 雅人, 鹿内 智史, 伊野 善彦, 西村 庸子, 秋元 太志, 松浦 基樹, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 181 - 181  2019年08月

Cadaver Surgery Multi Angleな手術教育と研究

玉手 雅人, 松浦 基樹, 長尾 沙智子, 西村 庸子, 杉尾 明香, 竹中 慎, 明石 祐史, 林 茂徳, 金尾 祐之, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 119 - 119  2019年08月

Fundamental Use of Surgical Energyを導入した手術教育

玉手 雅人, 松浦 基樹, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 30 ) 157 - 157  2019年08月

術前に良性嚢胞腺腫と診断し、腹腔鏡手術後に卵巣癌と診断された1例

郷久 晴朗, 岩崎 雅宏, 鹿内 智史, 常松 梨紗, 阿部 秀悦, 小川 万梨絵, 西村 庸子, 玉手 雅人, 寺田 倫子, 松浦 基樹, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 265 - 265  2019年08月

早期子宮体癌の診断で腹腔鏡下手術を施行した症例の腹腔細胞診に関する検討

西村 庸子, 石堂 茉泉, 神 未央奈, 長尾 沙智子, 玉手 雅人, 寺田 倫子, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 162 - 162  2019年08月

卵巣移動術後の内膜症性嚢胞に対し腹腔鏡で治療し得た1例

鹿内 智史, 玉手 雅人, 神 未央奈, 伊野 善彦, 鈴木 将裕, 西村 庸子, 松浦 基樹, 寺本 瑞絵, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 186 - 186  2019年08月

手術に応用できるドライボックス練習を目指して ロングテールの長さ、ショートテールの長さは、何cmが適切か?

青木 美帆子, 鈴木 幸雄, 仙波 恵樹, 平賀 裕章, 長尾 沙智子, 吉泉 絵理, 遠山 篤史, 山本 さやか, 吉野 育典, 天雲 千晶, 友野 勝幸, 矢田 大輔, 角 暢浩, 玉手 雅人, 竹中 慎, 松浦 基樹, 林 茂徳, 宮城 悦子

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 119 - 119  2019年08月  [査読有り]

手術に応用できるドライボックス練習を目指して ロングテールの長さ、ショートテールの長さは、何cmが適切か?

青木 美帆子, 鈴木 幸雄, 仙波 恵樹, 平賀 裕章, 長尾 沙智子, 吉泉 絵理, 遠山 篤史, 山本 さやか, 吉野 育典, 天雲 千晶, 友野 勝幸, 矢田 大輔, 角 暢浩, 玉手 雅人, 竹中 慎, 松浦 基樹, 林 茂徳, 宮城 悦子

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  35 ( Suppl.I ) 119 - 119  2019年08月

子宮内膜癌細胞におけるタイト結合分子claudin-2の関与

郷久 晴朗, 嶋田 浩志, 玉手 雅人, 秋元 太志, 西村 庸子, 寺田 倫子, 松浦 基樹, 岩崎 雅宏, 小島 隆, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  58 ( Suppl.1 ) 320 - 320  2019年05月

子宮体癌におけるKRAS変異の意義

松浦 基樹, 西村 庸子, 玉手 雅人, 寺田 倫子, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  58 ( Suppl.1 ) 319 - 319  2019年05月

子宮頸部原発大細胞神経内分泌癌の細胞像

寺本 瑞絵, 西村 庸子, 秋元 太志, 玉手 雅人, 磯山 響子, 小川 万梨絵, 寺田 倫子, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 齊藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  58 ( Suppl.1 ) 270 - 270  2019年05月

早期子宮体癌における腹腔細胞診に関する検討

西村 庸子, 松浦 基樹, 玉手 雅人, 寺田 倫子, 郷久 晴朗, 寺本 瑞絵, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  58 ( Suppl.1 ) 225 - 225  2019年05月

子宮体部漿液性癌18例の検討

寺田 倫子, 松浦 基樹, 西村 庸子, 玉手 雅人, 郷久 晴朗, 岩崎 雅宏, 寺本 瑞絵, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  58 ( Suppl.1 ) 276 - 276  2019年05月

MR Imaging of Secondary Massive Ovarian Edema Caused by Ovarian Metastasis from Appendiceal Adenocarcinoma.

Tanaka YO, Takazawa Y, Matsuura M, Omatsu K, Takeshima N, Matsueda K

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   18 ( 2 ) 111 - 112  2019年04月  [査読有り]  [国内誌]

DOI PubMed

TLHにおいてどうすれば尿管、子宮動脈は簡単に同定できるのか

山下 真祐子, 松浦 基樹, 玉手 雅人, 野呂 薫, 寺田 倫子, 寺本 瑞絵, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  63 ( 1 ) 67 - 67  2019年03月

出血リスクが高い症例における帝王切開術の工夫

岡田 匡永, 玉手 雅人, 長尾 沙智子, 黒川 晶子, 鈴木 利理, 田渕 雄大, 松浦 基樹, 水内 将人, 岡村 直樹, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  63 ( 1 ) 71 - 71  2019年03月

Efficacy of liquid-based genetic diagnosis of endometrial cancer.

Matsuura M, Yamaguchi K, Tamate M, Satohisa S, Teramoto M, Iwasaki M, Sugita S, Hasegawa T, Koubo R, Takane K, Ikenoue T, Furukawa Y, Saito T

Cancer science ( Wiley )  109 ( 12 ) 4025 - 4032  2018年12月  [査読有り]

DOI PubMed

TLHにおけるデバイスの選択について

西村 庸子, 松浦 基樹, 石堂 茉泉, 長尾 沙智子, 玉手 雅人, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  23 ( 7 ) OS139 - 3  2018年12月

子宮体癌に対するロボット支援下子宮全摘術を円滑に行うために

松浦 基樹, 石堂 茉泉, 長尾 沙智子, 西村 庸子, 玉手 雅人, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  23 ( 7 ) OS142 - 5  2018年12月

当科におけるLSIL以上の細胞診異常妊婦の経過

石岡 伸一, 真里谷 奨, 金 美善, 玉手 雅人, 松浦 基樹, 黒田 敬史, 郷久 晴朗, 寺本 瑞絵, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  57 ( Suppl.2 ) 673 - 673  2018年10月

Treatment and prognosis of recurrent uterine leiomyosarcomas in last 5 years

Motoki Matsuura

International Journal of Gynecological Cancer   28   50  2018年10月  [査読有り]

The role of claudin-2 on the malignancy of human endometrioid carcinoma tissues

Satohisa Seiro, Shimada Hiroshi, Kohno Takayuki, Konno Takumi, Tamate Masato, Matsuura Motoki, Teramoto Mizue, Akimoto Taishi, Iwasaki Masahiro, Kojima Takashi, Saito Tsuyoshi

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER ( BMJ PUBLISHING GROUP )  28   109 - 109  2018年10月  [査読有り]

Recurrence after total laparoscopic hysterectomy without morcellation for smooth muscle tumors of uncertain malignant potential: A rare case report

Motoki Matsuura

International Journal of Gynecological Cancer   28   84  2018年10月  [査読有り]

腹腔鏡下子宮体癌手術における工夫

石堂 茉泉, 松浦 基樹, 斉藤 公仁, 鹿内 智史, 西村 庸子, 玉手 雅人, 秋元 太志, 郷久 晴朗, 寺本 瑞絵, 岩崎 雅宏, 斎藤 豪

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  66回   0106 - 0106  2018年09月

次世代術者のキャリアとビジョン〜悪性腫瘍手術を見据えて〜 守破離 現状直視と未来のビジョン

玉手 雅人, 松浦 基樹, 明石 祐史, 寒河江 悟, 齋藤 豪

日本産科婦人科内視鏡学会雑誌 ( (一社)日本産科婦人科内視鏡学会 )  34 ( Suppl.I ) 144 - 144  2018年08月

Comparison of human papillomavirus genotyping and cytology triage, COMPACT Study: Design, methods and baseline results in 14 642 women.

Satomi Aoyama-Kikawa, Hiromasa Fujita, Sharon J B Hanley, Mitsunori Kasamo, Kokichi Kikuchi, Toshihiko Torigoe, Yoshihiro Matsuno, Akiko Tamakoshi, Takayuki Sasaki, Motoki Matsuura, Yasuhito Kato, Peixin Dong, Hidemichi Watari, Tsuyoshi Saito, Kazuo Sengoku, Noriaki Sakuragi

Cancer science   109 ( 6 ) 2003 - 2012  2018年06月  [査読有り]  [国際誌]

　概要を見る

Although cytology-based screening programs have significantly reduced mortality and morbidity from cervical cancer, the global consensus is that primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplasia (CIN) and invasive cancer. However, the optimal triage strategy for HPV-positive women to avoid over-referral to colposcopy may be setting specific. As Japan requires data that have been generated domestically to modify screening guidelines, we conducted a 3-year prospective study, COMparison of HPV genotyping And Cytology Triage (COMPACT), to evaluate the potential role of HPV16/18 partial genotyping and cytology for primary HPV screening. In total, 14 642 women aged 20 to 69 years undergoing routine screening at 3 centers in Hokkaido were enrolled. Conventional cytology and HPV testing were carried out. Women with abnormal cytology or HPV16/18 positivity underwent colposcopy. Those with 12 other high-risk (hr) HPV types underwent repeat cytology after 6 months. Primary study endpoints were detection of high-grade cervical disease defined as CIN2/CIN3 or greater as determined by consensus pathology. Prevalence of cytological abnormalities was 2.4%. hrHPV, HPV 16, and HPV 18 were detected in 4.6%, 0.9%, and 0.3% of women, respectively. HPV16/18 were detected in all (8/8) invasive cervical cancers and in all (2/2) adenocarcinomas in situ. Both cytological abnormalities and hrHPV positivity declined with increasing age. This is the first Japanese study to investigate the role of partial genotyping and cytology in an HPV-based screening program. Results should help policy-makers develop guidelines for future cervical screening programs and management of cervical abnormalities based on HPV genotype.

DOI PubMed

術前の良悪性の診断が困難だった卵巣腫瘍症例の検討

鈴木 利理, 玉手 雅人, 長尾 沙智子, 田渕 雄大, 松浦 基樹, 齋藤 豪

産婦人科手術 ( (株)メジカルビュー社 )  ( 29 ) 171 - 171  2018年06月

遺伝性乳癌卵巣癌症候群(HBOC)における子宮頸部・内膜細胞診の検討

寺本 瑞絵, 柏木 葉月, 秋元 太志, 玉手 雅人, 寺田 倫子, 鈴木 美和, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  57 ( Suppl.1 ) 220 - 220  2018年04月

子宮内膜細胞診の有用性 子宮内膜液状化細胞診検体による遺伝子解析研究

松浦 基樹, 玉手 雅人, 郷久 晴朗, 寺本 瑞絵, 幸保 莉香, 畠山 晴良, 山口 貴世志, 杉田 真太朗, 池上 恒雄, 岩崎 雅宏, 長谷川 匡, 古川 洋一, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  57 ( Suppl.1 ) 123 - 123  2018年04月

LOSS OF ASPP2 PROMOTES CELL INVASION AND MIGRATION VIA YAP IN HUMAN ENDOMETRIAL CANCER

Motoki Matsuura

International Journal of Gynecological Cancer    2018年

DEVICES IN LAPAROSCOPIC SURGERY FOR ENDOMETRIAL CANCER

Motoki Matsuura

International Journal of Gynecological Cancer    2018年

Recurring Ovarian Primary Glioblastoma with Effective Carboplatin plus Etoposide Therapy

Motoki Matsuura

International Journal of Gynecological Cancer    2018年

当科での広間膜内筋腫に対する核出術における手術戦略

田渕 雄大, 玉手 雅人, 長尾 沙智子, 杉尾 明香, 明石 祐史, 松浦 基樹, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  22 ( 7 ) SF036 - 05  2017年12月

子宮全摘術における腟管切開と縫合

玉手 雅人, 松浦 基樹, 長尾 沙智子, 杉尾 明香, 明石 祐史

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  22 ( 7 ) EP056 - 01  2017年12月

変性筋腫核出術の工夫

岡田 匡氷, 玉手 雅人, 田渕 雄大, 長尾 沙智子, 杉尾 明香, 明石 祐史, 松浦 基樹, 斎藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  22 ( 7 ) SF036 - 06  2017年12月

診療、教育、研究の充実にはオフの活動が不可欠!

齋藤 豪, 松浦 基樹, 玉手 雅人, 岩崎 雅宏, 郷久 晴朗, 寺田 倫子

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  22 ( 7 ) 3 - 1  2017年12月

膜を意識して行う腹腔鏡下En bloc骨盤リンパ節郭清

松浦 基樹, 玉手 雅人, 斎藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  22 ( 7 ) SF113 - 02  2017年12月

子宮体癌における予後因子と子宮頸部細胞診所見の関連性の検討

田中 綾一, 鈴木 孝浩, 玉手 雅人, 寺田 倫子, 松浦 基樹, 鈴木 美和, 高橋 円, 郷久 晴朗, 寺本 瑞絵, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  56 ( Suppl.2 ) 726 - 726  2017年10月

Comparison of secondary cytoreductive surgery plus chemotherapy with chemotherapy alone for recurrent epithelial ovarian, tubal, or peritoneal carcinoma A propensity score-matched analysis of 112 consecutive patients

Akimasa Takahashi, Kazuyoshi Kato, Motoki Matsuura, Takahiro Katsuda, Maki Matoda, Hidetaka Nomura, Sanshiro Okamoto, Hiroyuki Kanao, Eiji Kondo, Kohei Omatsu, Kuniko Utsugi, Nobuhiro Takeshima

MEDICINE ( LIPPINCOTT WILLIAMS & WILKINS )  96 ( 37 ) e8006  2017年09月  [査読有り]

　概要を見る

To compare secondary cytoreductive surgery (SCS) plus chemotherapy with chemotherapy alone in Japanese patients with recurrent epithelial ovarian, tubal, or peritoneal cancer (ROC).From our institutional database, we identified 112 patients who underwent therapy for ROC between 2005 and 2013. Of the 112 patients, 77 received salvage chemotherapy alone (CT group) and 35 received SCS plus chemotherapy (SCS group). To reduce the impact of treatment selection bias on treatment outcomes, propensity score-matching analysis was used.In the entire cohort, prognostic features were poorer in the CT group than in the SCS group. The platinum-free interval was significantly lower (15.35 months vs 30.77 months), cancer antigen 125 (CA125) level was significantly higher (247.38IU/mL vs 83.17 IU/mL), and number of solitary recurrence sites was significantly lower in the CT group than in the SCS group. The matched cohort consisted of 29 CT and 29 SCS patients with a median follow-up period of 24 and 58 months, respectively. In the matched cohort, progression-free survival (PFS) was longer in the SCS group than in the CT group (P=.02); however, overall survival did not differ (P=.23).SCS might be associated with improved PFS in ROC patients. SCS is beneficial in appropriately selected ROC patients.

DOI PubMed

Clinicopathological Features of Early and Late Recurrence of Endometrial Carcinoma After Surgical Resection

Akimasa Takahashi, Motoki Matsuura, Maki Matoda, Hidetaka Nomura, Sanshiro Okamoto, Hiroyuki Kanao, Eiji Kondo, Kohei Omatsu, Kazuyoshi Kato, Kuniko Utsugi, Nobuhiro Takeshima

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER ( BMJ PUBLISHING GROUP )  27 ( 5 ) 967 - 972  2017年06月  [査読有り]

　概要を見る

Objectives: The incidence of endometrial carcinoma has been increasing annually in developed nations; it is currently the secondmost common gynecological malignancy. Although the majority of patients are diagnosed at an early stage, 15% to 20% reportedly recur; consequently, patients are usually followed clinically for 3 years after the initial curative surgery. We therefore aimed to determine the incidence and clinicopathological features of early and late recurrences of endometrial carcinoma after surgical resection.Materials and Methods: This retrospective study was performed using the clinical records of 2233 patients who underwent surgical resection for endometrial carcinoma between January 1970 and December 2009 at a single cancer center. Tumor recurrenceswere classified as early (<5 years) and late (>5 years) after initial surgery. Clinicopathological variables and tumor recurrence patterns were compared between the early and late recurrence groups. Survival analysis was performed using the Kaplan-Meier method.Results: Among 2233 study patients, 255 (11.4%) experienced endometrial carcinoma recurrence; of these, early and late recurrences occurred in 232 (91.0%) and 23 (9.0%) patients, respectively. Late recurrencewas associated with invasion of less than half of themyometrium at diagnosis and the presence of histopathological features of endometrioid adenocarcinoma with low- or intermediate-grade histological subtype and absence of lymphovascular invasion. After recurrence, there was no significant difference in overall survival between the early and late recurrence groups (P - 0.437). Furthermore, surgical treatment was associated with a significantly improved prognosis in the late recurrence group (P = 0.044).Conclusions: The findings of this study indicated that patients who initially underwent successful treatment for low-grade and early-stage endometrial carcinoma should be followed clinically for more than 5 years. In cases of late recurrence, surgical management may improve prognosis.

DOI PubMed

Rap1GAP inhibits tumor progression in endometrial cancer

Masato Tamate, Ryoichi Tanaka, Hiroyuki Osogami, Motoki Matsuura, Seiro Satohisa, Masahiro Iwasaki, Tsuyoshi Saito

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ( ACADEMIC PRESS INC ELSEVIER SCIENCE )  485 ( 2 ) 476 - 483  2017年04月  [査読有り]

　概要を見る

Objective: Endometrioid adenocarcinoma (EAC) is a common endometrial cancer with recent dramatic increases in incidence. Previous findings indicate that Rap1GAP acts as a tumor suppressor inhibiting Ras superfamily protein Rapl in multiple aggressive carcinomas; however, Rap1GAP expression in EAC has not been investigated. In this study, the tumor suppressing activity of Rap1GAP in EAC was explored. Methods: EAC cell lines were used to examine Rapl GAP levels by real-time RT-PCR and western blotting and the effects of Rap1GAP on cancer cell invasion and migration. Rap1GAP expression was analyzed by immunohistochemical staining for Rapi GAP, E-cadherin in surgically resected tumors of 114 EAC patients scored according to EAC differentiation grade. Prognostic variables such as age, stage, grade, tumor size, and immunostaining for Rap1GAP, E-cadherin were evaluated using Cox regression multivariate analysis. Results: Low Rap1GAP expression was detected in poorly differentiated EAC cells. Rap1GAP deficiency significantly accelerated while Rapl deficiency decreased cancer cell migration and invasion. Patients with higher Rap1GAP, E-cadherin, and especially combined RaplGAP/E-cadherin levels had better overall survival than EAC patients with no or weak expression. In addition, Rapi GAP expression was an independent prognostic factor in EAC. Conclusions: Inhibition of Rap1GAP expression increases EAC cell migration and invasion through upregulation of Rapi. Low expression of Rap1GAP correlates with poor EAC differentiation. Our findings suggest that Rap1GAP is an important tumor suppressor with high prognostic value in EAC.(C) 2017 Elsevier Inc. All rights reserved.

DOI PubMed

A CASE OF PORT SITE METASTASIS AFTER LAPAROSCOPIC SURGERY FOR OVARIAN CARCINOSARCOMA

Motoki Matsuura

International Journal of Gynecological Cancer    2017年

IMPORTANCE OF UTERINE CERVICAL CERCLAGE TO MAINTAIN A SUCCESSFUL PREGNANCY FOR PATIENTS WHO UNDERGO VAGINAL RADICAL TRACHELECTOMY

Motoki Matsuura

International Journal of Gynecological Cancer    2017年

腹腔鏡下子宮筋腫核出術 各施設の工夫 当院における子宮筋腫核出の工夫 内膜に接した変性子宮への対応

玉手 雅人, 長尾 沙智子, 杉尾 明香, 松浦 基樹, 明石 祐史

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  21 ( 7 ) WS33 - 1  2016年12月

地域母子周産期施設における腹腔鏡手術件数の増加と利点

玉手 雅人, 長尾 沙智子, 杉尾 明香, 松浦 基樹, 明石 祐史

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  21 ( 7 ) DP78 - 6  2016年12月

腹水セルブロックにおける検討が治療方針決定に有用であった腹膜原発粘液性腺癌の1例

玉手 雅人, 長尾 沙智子, 竹田 倫子, 松浦 基樹, 寺本 瑞絵, 郷久 晴朗, 田中 綾一, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  55 ( Suppl.2 ) 494 - 494  2016年10月

化学療法による血小板減少に対する加味帰脾湯の効果

山下 芙貴子, 松浦 基樹, 箕輪 智幸, 鈴木 将裕, 田渕 雄大, 高田 さくら, 玉手 雅人, 寺本 瑞絵, 郷久 晴朗, 田中 綾一, 岩崎 雅宏, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  60 ( 1 ) 68 - 68  2016年03月

一期的手術を施行した血管内平滑筋腫の1例

箕輪 智幸, 松浦 基樹, 山下 芙貴子, 鈴木 将裕, 田渕 雄大, 高田 さくら, 玉手 雅人, 寺本 瑞絵, 郷久 晴朗, 田中 綾一, 岩崎 雅宏, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  60 ( 1 ) 62 - 63  2016年03月

術後20年目に局所再発した子宮体癌の1例

鈴木 将裕, 松浦 基樹, 山下 芙貴子, 箕輪 智幸, 田渕 雄大, 高田 さくら, 玉手 雅人, 寺本 瑞絵, 郷久 晴朗, 田中 綾一, 岩崎 雅宏, 齋藤 豪

北海道産科婦人科学会会誌 ( 北海道産科婦人科学会 )  60 ( 1 ) 71 - 71  2016年03月

Intravascular Large B-cell Lymphoma of the Bilateral Ovaries and Uterus in an Asymptomatic Patient with a t(11;22) (q23;q11) Constitutional Translocation

Yasuyuki Shigematsu, Motoki Matsuura, Noriko Nishimura, Naoko Tsuyama, Kengo Takeuchi, Yasuhito Terui, Nobuhiro Takeshima, Kiyohiko Hatake

INTERNAL MEDICINE ( JAPAN SOC INTERNAL MEDICINE )  55 ( 21 ) 3169 - 3174  2016年  [査読有り]

　概要を見る

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal diffuse large B-cell lymphoma, which is characterized by the intravascular growth of lymphoma cells, aggressive behavior, and an often fatal course. Patients with IVLBCL are usually symptomatic. Although any organ may be involved, localized lesions in the bilateral ovaries and uterus are extremely rare. We experienced a rare case of IVLBCL involving the bilateral ovaries and uterus in an asymptomatic patient with a t(11;22)(q23;q11) constitutional balanced translocation. Its association with the disease remains unknown. Even in asymptomatic situations, IVLBCL is possible, and the uterus and ovaries can be involved.

DOI PubMed

PRIMARY TREATMENT FOR ADVANCED EPITHERIAL OVARIAN CANCER IN A SINGLE INSTITUTION EXPERIENCE

Motoki Matsuura

International Journal of Gynecological Cancer    2016年

Assessment of peritoneal cytology in advanced-stage ovarian cancer patients at interval debulking surgery

Motoki Matsuura

International Journal of Gynecological Cancer    2016年

Preservation of fertility and subsequent childbirth after methotrexate treatment of placenta percreta: a case report

Masato Tamate, Motoki Matsuura, Shutaro Habata, Yushi Akashi, Ryoichi Tanaka, Shinichi Ishioka, Toshiaki Endo, Tsuyoshi Saito

Journal of Medical Case Reports ( BioMed Central Ltd. )  9 ( 1 ) 232  2015年12月  [査読有り]

　概要を見る

Introduction: Placenta percreta is associated with maternal morbidity and mortality. A hysterectomy is often needed to control the bleeding in such cases. However, it has been advocated that placenta percreta be managed conservatively to avoid massive pelvic bleeding and to preserve the patient's fertility. Here, we present a case of placenta percreta diagnosed by magnetic resonance imaging, and treated with systemic administration of methotrexate. Case presentation: A 27-year-old nulliparous Japanese woman at 39 gestational weeks had an uncomplicated vaginal delivery of a 3244-g infant. However, her placenta was not delivered, and we could not remove it manually. Contrast-enhanced magnetic resonance imaging indicated deep myometrial invasion by placental tissue and the whole placenta was strongly enhanced. Seven days post-partum, her serum human chorionic gonadotropin level was 12,656IU/L. Our patient hoped to preserve her uterus for a future pregnancy. She therefore received 13 courses of methotrexate (50mg/week, intravenous injection). Her serum human chorionic gonadotropin level was undetectable 97 days after the first methotrexate injection. At 117 days post-partum, she had a labor-like pain every three minutes and delivered the placenta. Our patient regained normal menses and at follow-up remained in good health. Two years later, she delivered a healthy daughter. Conclusion: We should try to detect placenta percreta in high-risk patients by any means. For low-risk patients, we should give a diagnosis swiftly and control any intrauterine infection and massive bleeding.

DOI PubMed

Secondary debulking surgery for isolated para-aortic nodal recurrence in endometrial cancer requiring partial resection of the inferior vena cava

Kazuyoshi Kato, Motoki Matsuura, Nobuhiro Takeshima

GYNECOLOGIC ONCOLOGY ( ACADEMIC PRESS INC ELSEVIER SCIENCE )  139 ( 3 ) 580 - 581  2015年12月  [査読有り]

　概要を見る

Objective. We report the details of a surgical technique for the cytoreduction of metastatic para-aortic lymph nodes with involvement of the inferior vena cava (IVC) requiring partial resection and repair of the IVC. Methods. A 52-year-old woman presented with endometrial cancer and isolated nodal recurrence involving the IVC. A vascular clamp was applied to the segment of the IVC that the metastatic lymph nodes had involved, and an en bloc resection of the para-aortic lymph nodes with the involved segment of the IVC was performed. Results and conclusion. In this case, a partial resection of the IVC was performed to enable a complete cytoreduction without encroaching on the tumor planes. No intraoperative or postoperative complications, including vascular complications, occurred. This surgical procedure can be adopted for the management of metastatic para-aortic lymph nodes in selected patients. (C) 2015 Elsevier Inc All rights reserved.

DOI PubMed

不妊治療前の治療的腹腔鏡/子宮鏡にて、子宮内膜増殖症を伴う子宮ポリープ状異型腺筋腫(APAM)と診断した1例

玉手 雅人, 明石 祐史, 長尾 沙智子, 西澤 庸子, 杉尾 明香, 松浦 基樹, 齋藤 豪

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  20 ( 7 ) OS217 - 6  2015年12月

Palonosetron in combination with 1-day versus 3-day dexamethasone for prevention of nausea and vomiting following paclitaxel and carboplatin in patients with gynecologic cancers: A randomized, multicenter, phase-II trial

Motoki Matsuura, Seiro Satohisa, Mizue Teramoto, Ryoichi Tanaka, Masahiro Iwasaki, Akira Nishikawa, Masahiro Mizunuma, Satoshi Tanaka, Osamu Hayakawa, Tsuyoshi Saito

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH ( WILEY-BLACKWELL )  41 ( 10 ) 1607 - 1613  2015年10月  [査読有り]

　概要を見る

AimChemotherapy-induced nausea and vomiting (CINV) can affect a patient's quality of life, leading to poor compliance with further treatments. Previous studies have provided minimal data about carboplatin-based regimens. Female sex is a known risk factor for CINV. The purpose of this study was to evaluate palonosetron plus single-dose dexamethasone (DEX) for preventing CINV caused by carboplatin plus paclitaxel combination therapy (TC regimen) in patients with gynecologic cancers. Material and MethodsPatients were recruited for this phase-II, multicenter, randomized trial from 12 hospitals in Hokkaido, Japan. Eligible patients were women with uterine cervical, endometrial or ovarian cancer scheduled to receive conventional TC regimen or dose-dense TC regimen; 116 patients were randomly assigned to receive palonosetron in combination with 1-day DEX or 3-day DEX. ResultsDuring the overall period, complete response (CR) was observed in 67.9% (95% confidence interval, 53.7-80.1) of patients in the 3-day DEX arm, and 60.7% (95% confidence interval, 46.8-73.5) of patients in the 1-day DEX arm; CR was significantly lower in the 1-day DEX arm if motion sickness was already present (P=0.0370). In the severe hyperemesis gravidarum cohort, CR in the 1-day DEX arm tended to be lower than in the 3-day DEX arm. ConclusionCombination therapy of palonosetron and 1-day DEX was effective for subjects undergoing a TC regimen for gynecologic cancers. However, the possibility of reduced efficacy of 1-day only DEX therapy in women undergoing a TC regimen could not be refuted and requires further investigation.

DOI PubMed

腹腔鏡および子宮鏡にて子宮内膜増殖症を伴う子宮ポリープ状異型腺筋腫と診断した1例

玉手 雅人, 寺本 瑞絵, 竹田 倫子, 松浦 基樹, 郷久 晴朗, 田中 綾一, 岩崎 雅宏, 齋藤 豪

日本臨床細胞学会雑誌 ( (公社)日本臨床細胞学会 )  54 ( Suppl.2 ) 561 - 561  2015年10月

[One-stage resection of intravenous leiomyomatosis extending into the right atrium].

Yanagiya A, Yamada O, Nanbu T, Hamada H, Takada J, Matsuura M, Tabuchi Y

Kyobu geka. The Japanese journal of thoracic surgery ( 南江堂 )  68 ( 3 ) 188 - 191  2015年03月  [査読有り]

PubMed CiNii

Rap1GAPの発現と子宮体部類内膜腺癌の分化度(Expression of Rap1GAP and differentiation of endometrioid adenocarcinoma in endometrial cancer)

玉手 雅人, 田中 綾一, 幅田 周太朗, 杉尾 明香, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

日本癌学会総会記事 ( (一社)日本癌学会 )  73回   P - 2080  2014年09月

Prediction of the therapeutic effect of dienogest in ovarian endometrial cysts using the apparent diffusion coefficient

Motoki Matsuura, Masato Tamate, Yuta Tabuchi, Sakura Takada, Ryoichi Tanaka, Masahiro Iwasaki, Tsuyoshi Saito

GYNECOLOGICAL ENDOCRINOLOGY ( INFORMA HEALTHCARE )  30 ( 8 ) 597 - 599  2014年08月  [査読有り]

　概要を見る

The purpose of this study was to investigate whether apparent diffusion coefficient (ADC) mean values can be used for predicting the treatment response in ovarian endometrial cyst patients with dienogest (DNG) administration. Eighteen patients received DNG (2 mg/day, orally) for 60 days, among whom 26 ovarian endometrial cysts were retrospectively identified. Mean ADC values of individual ovarian endometrial cysts were obtained by ADC maps inside the tumor. There was a significant correlation between ADC values and reduction ratio. When calculating the mean ADC values for three groups; more than 50%, 50-25% and less than 25%, ADC values significantly increased with increasing reduction ratio; 2.05 x 10(-3) mm(2)/s, 1.28 x 10(-3) mm(2)/s and 0.94 x 10(-3) mm(2)/s, respectively (p = 0.0180). Multiple regression analysis by reduction ratio (%), ADC mean values (x 10(-3) mm(2)/s), tumor longest diameter (cm) and CA125 (Wml) revealed that tumor reduction ratio by DNG administration could be predicted by the following equation; R=19.3 + 24.0x - 0.4y + 0.1z (R: Reduction ratio, x: ADC mean, y: Longest diameter, z: CA125). In conclusion, the ADC mean value is useful for the prediction of the treatment response in ovarian endometrial cyst patients with DNG administration.

DOI PubMed

Low-dose SN-38 with paclitaxel induces lethality in human uterine cervical adenocarcinoma cells by increasing caspase activity

Mizue Teramoto, Takahiro Suzuki, Seiro Satohisa, Yushi Akashi, Motoki Matsuura, Miwa Suzuki, Ryoichi Tanaka, Tsuyoshi Saito

MEDICAL MOLECULAR MORPHOLOGY ( SPRINGER JAPAN KK )  47 ( 1 ) 31 - 37  2014年03月  [査読有り]

　概要を見る

Combination of anticancer drugs may provide a rational molecular basis for novel chemotherapeutic strategies. Paclitaxel and SN-38 (an active metabolite of CPT-11) are effective for many kinds of cancer. Therefore, we investigated the possibility that combination of these drugs could be effective against cervical adenocarcinoma cells. In this study, we examined cell growth inhibition after 96 h using the MTT assay and examined the release of fragmented DNA into the cytoplasm during apoptotic cell death by PI staining. Single and combined use of paclitaxel and SN-38 produced significant cytolethality against the cervical adenocarcinoma cell line CAC-1. Addition of a low concentration of SN-38 reduced the IC50 value of paclitaxel compared to that without SN-38, although the low concentration of paclitaxel did not enhance the cytotoxicity of SN-38. FACS scan analysis suggested that these drugs induced apoptosis and cell cycle arrest, and that caspase-3 and -7 were activated in the process. MTT assay and the IC50 demonstrated that paclitaxel had strong cytotoxicity against CAC-1 as well as other cancer cells. In this study, though only a single cell line was used for the experiment and the data are limited, our results suggest that paclitaxel together with low-dose CPT-11 is a promising basis for a new combination cancer chemotherapy.

DOI PubMed

手術手技を定型化することによる手術成績の変化に関する検討

田渕 雄大, 松浦 基樹, 玉手 雅人, 明石 祐史

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  18 ( 7 ) 633 - 633  2013年11月

腹腔鏡下子宮筋腫核出術における術前GnRHagonistの有用性と筋腫縮小率の予測

玉手 雅人, 田渕 雄大, 足立 英文, 杉尾 明香, 松浦 基樹, 森下 美幸, 明石 祐史

日本内視鏡外科学会雑誌 ( (一社)日本内視鏡外科学会 )  18 ( 7 ) 634 - 634  2013年11月

当科におけるASC-US症例の臨床像

竹浪 奈穂子, 松浦 基樹, 玉手 雅人, 谷垣 衣理, 早川 修

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 ( 東北連合産科婦人科学会・北日本産科婦人科学会 )  60回   98 - 98  2012年09月

Evaluation of cervical conization as a definitive treatment for microinvasive cervical carcinoma and cervical intraepithelial neoplasia grade 3

Noriko Takeda, Takahiro Suzuki, Miwa Suzuki, Motoki Matsuura, Ryoichi Tanaka, Miho Fujii, Eiki Ito, Tsuyoshi Saito

ARCHIVES OF GYNECOLOGY AND OBSTETRICS ( SPRINGER HEIDELBERG )  285 ( 2 ) 453 - 457  2012年02月  [査読有り]

　概要を見る

The aim of the study was to evaluate disease persistence after conization of CIN3 and microinvasive cervical carcinoma. Medical records from a total of 231 patients were reviewed. The prevalence of CIN3 and cervical carcinoma diagnosed by means of conization were analyzed. All conizations were performed under lumbar anesthesia using a laser technique. Of the 231 patients, 25 had margin involvement with CIN3 or microinvasive carcinoma. Among these 25 patients, 10 underwent hysterectomy. Two of these 10 patients had CIN3 and eight had microinvasive carcinoma. Residual disease was observed in hysterectomy specimens from 9 of the 10 patients. Of the eight patients diagnosed with microinvasion from post-cone hysterectomy specimens, four had CIN3 and three had microinvasive carcinoma. The three patients with microinvasion were found to have a larger area of residual disease as compared with other patients with margin involvement. Conization alone seems to be a reasonable treatment for patients with CIN1, 2, 3, and microinvasive carcinoma. For adenocarcinoma, in situ treatment with conization alone is possible but requires careful follow-up. Hysterectomy appears to be a safe treatment option for microinvasive adenocarcinoma, although follow-up by cytology is sometimes possible in cases with negative surgical margins.

DOI PubMed

Statin-mediated reduction of osteopontin expression induces apoptosis and cell growth arrest in ovarian clear cell carcinoma

Motoki Matsuura, Takahiro Suzuki, Miwa Suzuki, Ryoichi Tanaka, Eiki Ito, Tsuyoshi Saito

ONCOLOGY REPORTS ( SPANDIDOS PUBL LTD )  25 ( 1 ) 41 - 47  2011年01月  [査読有り]

　概要を見る

Poor prognosis in ovarian clear cell carcinoma is associated with the expression of a defined set of proteins including osteopontin (OPN) and integrin. Statins, a family of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors, are currently being investigated for the treatment and prevention of cancer. In this study, we investigated the effects of simvastatin on ovarian clear cell carcinoma (OCCC) cells in vitro and in vivo and elucidated the mechanism of drug action. Changes in OPN gene expression were determined by real-time RT-PCR, and an MTT assay was performed to determine effects on cell proliferation. Finally, a xenograft tumor model was constructed to evaluate the effects of simvastatin on cell proliferation and apoptosis in vivo. According to our experimental results. OPN is an important protein in OCCC. Simvastatin inhibited OCCC cell proliferation, and the inhibition rate was approximately 40% to 50% after treatment with 10 mu M simvastatin for 48 h. In the xenograft studies, simvastatin treatment resulted in a significant growth inhibition. Furthermore, the mice treated with simvastatin survived significantly longer compared to the control groups. In conclusion, simvastatin has anticancer effects in vitro and in vivo. Further confirmation of the anticancer effects of statins in future studies will increase the scope for OCCC treatment.

DOI PubMed

Osteopontin is a new target molecule for ovarian clear cell carcinoma therapy

Motoki Matsuura, Takahiro Suzuki, Tsuyoshi Saito

CANCER SCIENCE ( WILEY-BLACKWELL )  101 ( 8 ) 1828 - 1833  2010年08月  [査読有り]

　概要を見る

Recent studies have demonstrated overexpression of osteopontin (OPN) in ovarian clear cell carcinoma. Here, we revealed the role of OPN in invasiveness in ovarian clear cell carcinoma. We used immunofluorescence analysis to detect OPN in a total of 160 patient-derived specimens. Ovarian clear cell carcinoma cell lines, RMG-1 and TOV-21G, were used to monitor changes in OPN and integrin levels, and cell invasiveness following treatment with OPN, simvastatin, and transfection with siRNA. Immunofluorescence analysis revealed statistically significant differences among the histological groups, and ovarian clear cell carcinoma expressed a strong OPN signal. The OPN receptors, alpha v and 5, and beta 1 and 3 integrins, were increased after treatment with OPN. Invasion assays indicated that OPN enhanced in vitro extracellular matrix invasion dose-dependently in ovarian clear cell carcinoma. Simvastatin significantly reduced expression of OPN and the integrins, and decreased ECM invasion. RNA interference also suppressed ECM invasion. These results suggest that down- or up-regulation of OPN is involved in carcinoma cell invasion. We thus conclude that OPN regulation could have a crucial role in ovarian clear cell carcinoma therapy. (Cancer Sci 2010).

DOI PubMed

Prediction of Histologic Type and Lymph Node Metastasis for Advanced Ovarian Cancer on Uterine Cervical and Endometrial Cytology

Miwa Suzuki, Takahiro Suzuki, Motoki Matsuura, Masahiro Iwasaki, Ryoichi Tanaka, Eiki Ito, Miho Fujii, Tsuyoshi Saito

ACTA CYTOLOGICA ( SCI PRINTERS & PUBL INC )  54 ( 4 ) 575 - 581  2010年07月  [査読有り]

　概要を見る

Objective To evaluate usefulness of uterine cervical and endometrial cytology for detecting ovarian cancer and predicting histologic type. Study Design Retrospective analysis was performed on uterine cervical and endometrial cytology data on 163 patients with ovarian cancer. Results Cervical and endometrial abnormalities were detected in 10 and 19 of the patients evaluated. Patients whose cervical and endometrial cytology revealed abnormal cells were classified as having ovarian cancer at International Federation of Gynecology and Obstetrics (FIGO) stages ill and IV Peritoneal cytology proved positive in many of the patients with abnormal findings on uterine cytologic analysis. Of the 19 patients with positive uterine cytologic findings, 12 had recurrence tases were detected in 9 of 19 patients. Our findings indicated that it is possible to predict histologic type in ovarian cancer in 90% of cases of positive cervical smears and 79% of abnormal endometrial smears. Conclusion Our study showed that most of the ovarian cancer cases that had abnormalities in uterine cervical and endometrial cytologic tests exhibited progression of disease. As a consequence, Our findings indicate that it is possible to predict development of ovarian cancer and its histologic type using cytology screening. (Acta Cytol 2010;54:575-581)

DOI PubMed

Successful Uterus-Preserving Surgery for Treatment of Chemotherapy-Resistant Placenta Increta

Toshiaki Endo, Takuhiro Hayashi, Ayumi Shimizu, Motoki Matsuura, Masahito Mizuuchi, Kunihiko Nagasawa, Yoshiaki Ezaka, Tuyoshi Baba, Shinichi Ishioka, Tsuyoshi Saito

GYNECOLOGIC AND OBSTETRIC INVESTIGATION ( KARGER )  69 ( 2 ) 112 - 115  2010年  [査読有り]

　概要を見る

Treatment of placenta increta often entails abdominal total hysterectomy. We present a case of placenta increta in which 3-dimensional computed tomography shows very high blood flow to the placenta, even after chemotherapy with methotrexate. Nonetheless, we were able to remove the region of the uterus that had been invaded by chorionic villi. Massive bleeding during the operation was prevented by ligation of the hypogastric artery and local injection of vasopressin. The combination of chemotherapy and partial resection of the uterus is quite a unique treatment for placenta increta patients. This approach enabled preservation of the uterus and the patient's fertility. We suggest this procedure could be one of the treatments for patients who have placenta increta and wish to retain their fertility. Copyright (C) 2009 S. Karger AG, Basel

DOI PubMed

Chemotherapy (CT) with radiotherapy versus CT alone for FIGO Stage IIIc endometrial cancer

M. Matsuura, T. Suzuki, M. Morishita, R. Tanaka, E. Ito, T. Saito

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY ( I R O G CANADA, INC )  30 ( 1 ) 40 - 44  2009年  [査読有り]

　概要を見る

To determine optimal treatment for women with Stage IIIc endometrial carcinoma, extended-field radiotherapy (RT) plus chemotherapy (CT) was compared versus CT alone as adjuvant therapy. Twenty-nine patient's with FIGO Stage IIIc endometrial cancer who underwent adjuvant treatment with 4.4 courses of CT (CAP or TC/DC) or 4.5 Courses of CT (CAP or TC/DC) plus external pelvic RT (50 Gy) with paraaortic boost after surgery between 1992 and 2004 were retrospectively assessed. Fifteen patients underwent CT alone and 14 received combined treatment with CT/RT. Following treatment, the recurrence rate was 46.6% and 28.5% in the two treatment arms. respectively. There was a significant (p < 0.05) difference in the pelvic recurrence rate (33.3% and 7.1%, respectively). Combined treatment with RT/CT was associated with a better survival rate than CT alone (78% versus 62%, respectively). In Stage IIIc endometrial cancer, combined treatment with RT and CT reduces pelvic recurrence and improves progression-free survival and overall Survival compared with CT alone.

PubMed

Analgesic Efficacy of Controlled-release Oxycodone in Patients With Uterine or Ovarian Cancer

Takahiro Suzuki, Miyuki Morishita, Eiki Ito, Motoki Matsuura, Ryoichi Tanaka, Tsuyoshi Saito

AMERICAN JOURNAL OF THERAPEUTICS ( LIPPINCOTT WILLIAMS & WILKINS )  15 ( 1 ) 31 - 35  2008年01月  [査読有り]

　概要を見る

Treatment with opioid analgesics often causes adverse reactions that may make continuous use of such drugs difficult. We investigated the efficacy and safety of controlled-release oxycodone in the treatment of gynecologic cancer pain. The patients included 14 with cervical cancer, 6 with corpus cancer, and 17 with ovarian cancer. Treatment with controlled-release oxycodone was started at 5 mg/dose when pain control using nonsteroidal anti-inflammatory drugs became ineffective. The dose was titrated to the optimal level over a mean duration of 2.34 +/- 1.13 days, and the initially optimal dose was 18.92 +/- 5.23 mg/day. Although no patients experienced confusion, vomiting, or respiratory depression, 17 patients experienced adverse events, including constipation in 14 patients and nausea in 9 patients. The incidence of nausea was low in patients receiving oxycodone and prochlorperazine. In the present study, patients with moderate to severe pain caused by gynecologic cancer could successfully be treated with controlled-release oxycodone.

DOI PubMed