研究者詳細 - 菅原　和広

論文 - 菅原　和広

分割表示 61 件中 41 - 60 件目／全件表示 >>

宮口翔太, 大西秀明, 小島翔, 菅原和広, 桐本光,他

理学療法学 ( 日本理学療法士学会 ) 42 ( 3 ) 213 - 219 2015年 [査読有り]

【目的】本研究の目的は,電流強度および電極貼付部位の違いが経頭蓋直流電流刺激(transcranial direct current stimulation;以下,tDCS)の効果に与える影響を明らかにすることとした。【方法】対象は健常成人9名とした。tDCS介入条件は,陽極電極を左一次運動野領域に貼付し,陰極電極を対側前額部または対側一次運動野領域(bilateral tDCS)に貼付し,1.0mAまたは2.0mAにて10分間刺激する計4条件とした。各条件におけるtDCS介入前後に経頭蓋磁気刺激により左一次運動野領域を刺激し,運動誘発電位を記録した。【結果】bilateral_2.0mA条件においてのみtDCS介入前に比べ介入終了2分後,10分後の運動誘発電位が有意に増大した。【結論】bilateral tDCSにより2.0mAにて刺激することで,大脳皮質の興奮性が安定して増大することが明らかになった。

DOI CiNii

Effects of cathodal transcranial direct current stimulation to primary somatosensory cortex on short-latency afferent inhibition

Kojima S, Onishi H, Miyaguchi S, Kotan S, Sugawara K, Kirimoto H, Tamaki H

Neuroreport 15 ( 3 ) 270 - 278 2015年 [査読有り]

Plasticity of human motor associate and primary sensorimotor cortices induced by tDCS.

Kirimoto H, Miyaguchi S, Onishi H, Suzuki M, Sugawara K, Matsumoto T, Tamaki H

Adv Exerc Sports Physiol ( Japan Society of Exercise and Sports Physiology ) 21 ( 3 ) 47 - 52 2015年 [査読有り]

Nitsche and Paulus (2000) first described the efficacy of transcranial direct current stimulation (tDCS) for functional modulation of the human motor cortex. Since then, tDCS has been an increasingly useful technique for noninvasive brain stimulation that can be used not only for examining cortical function in healthy subjects, but also for facilitating treatments for various neurological disorders. The advantages of tDCS over other noninvasive brain stimulation methods include its ease of use, large electrode size allowing effect over a larger neural network, sham mode allowing controlled experiments and randomized controlled clinical trials. In this symposium, we plan to introduce the three points of studies about plastic changes of motor association cortex excitability induced by tDCS. 1) Transcranial direct current stimulation over the motor association cortex induces plastic changes in the ipsilateral primary motor and somatosensory cortices 2) The effects of cathodal transcranial direct current stimulation of the supplementary motor area on the function of anticipatory postural adjustments 3) Corticomotor excitability induced by anodal transcranial direct current stimulation with and without non-exhaustive movement

CiNii

視覚反応課題の反復練習が大脳皮質情報処理過程に及ぼす影響

菅原和広

理学療法学 ( 日本理学療法士学会 ) 41 ( 8 ) 552 - 554 2014年12月 [査読有り]

DOI CiNii

No relation between afferent facilitation induced by digital nerve stimulation and the latency of cutaneomuscular reflexes and somatosensory evoked magnetic fields

Sho Kojima, Hideaki Onishi, Kazuhiro Sugawara, Shota Miyaguchi, Hikari Kirimoto, Hiroyuki Tamaki, Hiroshi Shirozu, Shigeki Kameyama

FRONTIERS IN HUMAN NEUROSCIENCE ( FRONTIERS RESEARCH FOUNDATION ) 8 ( 8 ) doi: 10.3389/fnhum.2014.01023 2014年12月 [査読有り]

Primary motor cortex (M1) excitability can be assessed using transcranial magnetic stimulation (TMS) and can be modulated by a conditioning electrical stimulus delivered to a peripheral nerve prior to TMS. This is known as afferent facilitation (AF). The aim of this study was to determine whether AF can be induced by digital nerve stimulation and to evaluate the relation between the interstimulus interval (ISI) required for AF and the latency of the E2 component of the cutaneomuscular reflex (CMR) and the prominent somatosensory evoked field (SEF) deflection that occurs approximately 70 ms after digital nerve stimulation (P60m). Stimulation of the digital nerve of the right index finger was followed, at various time intervals, by single-pulse TMS applied to the contralateral hemisphere. The ISI between digital nerve stimulation and TMS was 20, 30, 40, 50, 60, 70, 80, 100, 140, 180, 200, or 220 ms. Single-pulse TMS was performed alone as a control. SEFs were recorded following digital nerve stimulation of the index finger, and the equivalent current dipole of prominent deflections that occurred around 70 ms after the stimulation was calculated. CMRs were recorded following digital nerve stimulation during muscle contraction. Motor evoked potentials (MEPs) were facilitated at an ISI between 50 and 100 ms in 11 of 13 subjects, and the facilitated MEP amplitude was larger than the unconditioned MEP amplitude (p < 0.01). There was no significant correlation between the ISI at which AF was maximal and the latency of the P60m component of the SEF (r = -0.50, p = 0.12) or the E2 component of the CMR (r = -0.54, p = 0.88). These results indicate that the precise ISI required for AF cannot be predicted using SEF or CMR.

DOI

Effect of Transcranial Static Magnetic Field Stimulation Over the Sensorimotor Cortex on Somatosensory Evoked Potentials in Humans

Hikari Kirimoto, Hiroyuki Tamaki, Takuya Matsumoto, Kazuhiro Sugawara, Makoto Suzuki, Mineo Oyama, Hideaki Onishi

BRAIN STIMULATION ( ELSEVIER SCIENCE INC ) 7 ( 6 ) 836 - 840 2014年11月 [査読有り]

Background: The motor cortex in the human brain can be modulated by the application of transcranial static magnetic field stimulation (tSMS) through the scalp. However, the effect of tSMS on the excitability of the primary somatosensory cortex (S1) in humans has never been examined. Objective: This study was performed to investigate the possibility of non-invasive modulation of S1 excitability by the application of tSMS in healthy humans. Methods: tSMS and sham stimulation over the sensorimotor cortex were applied to 10 subjects for periods of 10 and 15 min. Somatosensory evoked potentials (SEPs) following right median nerve stimulation were recorded before and immediately after, 5 min after, and 10 min after tSMS from sites C3' and F3 of the international 10-20 system of electrode placement. In another session, SEPs were recorded from 6 of the 10 subjects every 3 min during 15 min of tSMS. Results: Amplitudes of the N20 component of SEPs at C3' significantly decreased immediately after 10 and 15 min of tSMS by up to 20%, returning to baseline by 10 min after intervention. tSMS applied while recording SEPs every 3 min and sham stimulation had no effect on SEP. Conclusions: tSMS is able to modulate cortical somatosensory processing in humans, and thus might be a useful tool for inducing plasticity in cortical somatosensory processing. Lack of change in the amplitude of SEPs with tSMS implies that use of peripheral nerve stimulation to cause SEPs antagonizes alteration of the function of membrane ion channels during exposure to static magnetic fields. (C) 2014 Elsevier Inc. All rights reserved.

DOI

Induction of cortical plasticity for reciprocal muscles by paired associative stimulation

Makoto Suzuki, Hikari Kirimoto, Kazuhiro Sugawara, Makoto Watanabe, Shinobu Shimizu, Ikuyo Ishizaka, Sumio Yamada, Atsuhiko Matsunaga, Michinari Fukuda, Hideaki Onishi

BRAIN AND BEHAVIOR ( JOHN WILEY & SONS INC ) 4 ( 6 ) 822 - 832 2014年11月 [査読有り]

Background: Paired associative stimulation (PAS) is widely used to induce plasticity in the human motor cortex. Although reciprocal inhibition of antagonist muscles plays a fundamental role in human movements, change in cortical circuits for reciprocal muscles by PAS is unknown. Methods: We investigated change in cortical plasticity for reciprocal muscles during PAS. PAS consisted of 200 pairs of peripheral electric stimulation of the right median nerve at the wrist at a frequency of 0.25 Hz followed by transcranial magnetic stimulation of the left M1 at the midpoint between the center of gravities of the flexor carpi radialis (FCR) and extensor carpi radialis (ECR) muscles. Measures of motor cortical excitability included resting motor threshold (RMT), GABA(A)-mediated short-interval intracortical inhibition (SICI), and GABA(B)-mediated long-interval intracortical inhibition (LICI). Results: Motor evoked potential amplitude-conditioned LICI for the FCR muscle was significantly decreased after PAS (P = 0.020), whereas that for the ECR muscle was significantly increased (P = 0.033). Changes in RMT and SICI for the FCR and ECR muscles were not significantly different before and after PAS. Corticospinal excitability for both reciprocal muscles was increased during PAS, but GABA(B)-mediated cortical inhibitory functions for the agonist and antagonist muscles were reciprocally altered after PAS. Conclusion: These results implied that the cortical excitability for reciprocal muscles including GABA(B)-ergic inhibitory systems within human M1 could be differently altered by PAS.

DOI

Sensorimotor Modulation Differs with Load Type during Constant Finger Force or Position

Hikari Kirimoto, Hiroyuki Tamaki, Makoto Suzuki, Takuya Matsumoto, Kazuhiro Sugawara, Syo Kojima, Hideaki Onishi

PLOS ONE ( PUBLIC LIBRARY SCIENCE ) 9 ( 9 ) doi: 10.1371/journal.pone.0108 2014年09月 [査読有り]

During submaximal isometric contraction, there are two different load types: production of a constant force against a rigid restraint (force task), and maintenance of position against a constant load (position task). Previous studies reported that the time to task failure during a fatigue task was twice as long in the force task compared with the position task. Sensory feedback processing may contribute to these differences. The purpose of the current study was to determine the influence of load types during static muscle contraction tasks on the gating effect, i. e., attenuation of somatosensory-evoked potentials (SEPs) and the cortical silent period (cSP). Ten healthy subjects contracted their right first dorsal interosseus muscle by abducting their index finger for 90 s, to produce a constant force against a rigid restraint that was 20% of the maximum voluntary contraction (force task), or to maintain a constant position with 10 degrees abduction of the metacarpophalangeal joint against the same load (position task). Somatosensory evoked potentials (SEPs) were recorded from C3' by stimulating either the right ulnar or median nerve at the wrist while maintaining contraction. The cortical silent period (cSP) was also elicited by transcranial magnetic stimulation. Reduction of the amplitude of the P45 component of SEPs was significantly larger during the position task than during the force task and under control rest conditions when the ulnar nerve, but not the median nerve, was stimulated. The position task had a significantly shorter cSP duration than the force task. These results suggest the need for more proprioceptive information during the position task than the force task. The shorter duration of the cSP during the position task may be attributable to larger amplitude of heteronymous short latency reflexes. Sensorimotor modulations may differ with load type during constant finger force or position tasks.

DOI

Motor Cortex-Evoked Activity in Reciprocal Muscles Is Modulated by Reward Probability

Makoto Suzuki, Hikari Kirimoto, Kazuhiro Sugawara, Mineo Oyama, Sumio Yamada, Jun-ichi Yamamoto, Atsuhiko Matsunaga, Michinari Fukuda, Hideaki Onishi

PLOS ONE ( PUBLIC LIBRARY SCIENCE ) 9 ( 3 ) doi: 10.1371/journal.pone.0090 2014年03月 [査読有り]

Horizontal intracortical projections for agonist and antagonist muscles exist in the primary motor cortex (M1), and reward may induce a reinforcement of transmission efficiency of intracortical circuits. We investigated reward-induced change in M1 excitability for agonist and antagonist muscles. Participants were 8 healthy volunteers. Probabilistic reward tasks comprised 3 conditions of 30 trials each: 30 trials contained 10% reward, 30 trials contained 50% reward, and 30 trials contained 90% reward. Each trial began with a cue (red fixation cross), followed by blue circle for 1 s. The subjects were instructed to perform wrist flexion and press a button with the dorsal aspect of middle finger phalanx as quickly as possible in response to disappearance of the blue circle without looking at their hand or the button. Two seconds after the button press, reward/non-reward stimulus was randomly presented for 2-s duration. The reward stimulus was a picture of Japanese 10-yen coin, and each subject received monetary reward at the end of experiment. Subjects were not informed of the reward probabilities. We delivered transcranial magnetic stimulation of the left M1 at the midpoint between center of gravities of agonist flexor carpi radialis (FCR) and antagonist extensor carpi radialis (ECR) muscles at 2 s after the red fixation cross and 1 s after the reward/non-reward stimuli. Relative motor evoked potential (MEP) amplitudes at 2 s after the red fixation cross were significantly higher for 10% reward probability than for 90% reward probability, whereas relative MEP amplitudes at 1 s after reward/non-reward stimuli were significantly higher for 90% reward probability than for 10% and 50% reward probabilities. These results implied that reward could affect the horizontal intracortical projections in M1 for agonist and antagonist muscles, and M1 excitability including the reward-related circuit before and after reward stimulus could be differently altered by reward probability.

DOI

Electrical stimulation of denervated rat skeletal muscle retards trabecular bone loss in early stages of disuse musculoskeletal atrophy

H. Tamaki, K. Tomori, K. Yotani, F. Ogita, K. Sugawara, H. Kirimto, H. Onishi, N. Yamamoto, N. Kasuga

Journal of Musculoskeletal Neuronal Interactions ( International Society of Musculoskeletal and Neuronal Interactions ) 14 ( 2 ) 220 - 228 2014年 [査読有り]

Objectives: We aimed to determine the intensity of muscle stimulation required to prevent structural failure as well as bone and skeletal muscle loss after denervation-induced disuse. Methods: Seven-week-old rats (weight, 198-225 g) were randomly assigned to age-matched groups comprising control (CON), sciatic nerve denervation (DN) or direct electrical stimulation (ES) one day later [after denervation] with 4, 8 and 16 mA at 10 Hz for 30 min/day, six days/week, for one or three weeks. Bone architecture and mean osteoid thickness in histologically stained tibial sections and tension in tibialis anterior muscles were assessed at one and three weeks after denervation. Results: Direct ES with 16 mA generated 23-30% maximal contraction force. Denervation significantly decreased trabecular bone volume fraction, thickness and number, connectivity density and increased trabecular separation in the DN group at weeks one and three. Osteoid thickness was significantly greater in the ES16 group at week one than in the DN and other ES groups. Trabecular bone volume significantly correlated with muscle weight. Conclusions: Relatively low-level muscle contraction induced by low-frequency, high-intensity electrical muscle stimulation delayed trabecular bone loss during the early stages (one week after DN) of musculoskeletal atrophy due to disuse.

PubMed

Activation of the Human Premotor Cortex During Motor Preparation in Visuomotor Tasks

Kazuhiro Sugawara, Hideaki Onishi, Koya Yamashiro, Hikari Kirimoto, Atsuhiro Tsubaki, Makoto Suzuki, Hiroyuki Tamaki, Hiroatsu Murakami, Shigeki Kameyama

BRAIN TOPOGRAPHY ( SPRINGER ) 26 ( 4 ) 581 - 590 2013年10月 [査読有り]

担当区分：筆頭著者 , 責任著者

Functional brain mapping studies in humans suggest that both motor and premotor cortices interact during movement execution. The aim of this study was to investigate whether the premotor cortex also participates in motor planning. We measured movement-related cerebral fields (MRCFs) using magnetoencephalography from the left hemisphere of 12 healthy right-handed participants during two simple visuomotor tasks cued by two visual stimuli S1 and S2. Participants performed a unilateral task in which they always extended the right index finger after S2 presentation regardless of the color of S1 and a bilateral task in which they extended either the right or left index finger after S2 presentation according to the color of S1. Significantly higher MRCF activity was observed during the 500 ms S1 to S2 interval in the bilateral task than in the unilateral task. In the bilateral task trials, the latency of the peak MRCF during the S1 to S2 interval was 343.9 +/- A 73.5 ms after S1 presentation and that of the peak of movement-evoked field 1 was 33.4 +/- A 3.9 ms after movement onset in the bilateral task. Equivalent current dipoles at the peak MRCF were significantly medial (9.2 +/- A 12.1 mm) and anterior (19.8 +/- A 6.9 mm) to the reference location in the somatosensory cortex (area 3b) established by median nerve stimulation. This location corresponds to the dorsal premotor cortex. These findings suggest that activation of the premotor cortex observed during the interstimulus interval may represent a neurophysiological marker of response selection.

DOI

Effect of the number of pins and inter-pin distance on somatosensory evoked magnetic fields following mechanical tactile stimulation

Hideaki Onishi, Kazuhiro Sugawara, Koya Yamashiro, Daisuke Sato, Makoto Suzuki, Hikari Kirimoto, Hiroyuki Tamaki, Hiroatsu Murakami, Shigeki Kameyama

BRAIN RESEARCH ( ELSEVIER SCIENCE BV ) 1535 78 - 88 2013年10月 [査読有り]

Magnetoencephalography (MEG) recordings were collected to investigate the effect of the number of mechanical pins and inter-pin distance on somatosensory evoked magnetic fields (SEFs) following mechanical stimulation (MS). We used a 306-ch whole-head MEG system. SEFs were elicited through tactile stimuli with 1-, 2-, 3-, 4- and 8-pins using healthy participants. Tactile stimuli were applied to the tip of the right index finger. SEF following electrical stimulation of the index finger was recorded in order to compare the activity in the primary somatosensory cortex (S1) following MS. Prominent SEFs were recorded from the contralateral hemisphere approximately 54 ms (P50m) and 125 ms (P100m) after MS regardless of the number of pins. Equivalent current dipoles were located in the S1. The source activities for P50m and P100m significantly increased in tandem with the number of pins for MS. However, the increased ratios for the source activities according to the increase in the number of pins were significantly smaller than that induced by electrical stimulation, and when the number of the pins doubled from 1-pin to 2-pins, from 2-pins to 4-pins, and from 4-pins to 8-pins, Si activities increased by only 130%. Additionally, source activities significantly increased when the inter-pin distance increased from 2.4 to 7.2 mm. The number of stimulated receptors was considered to have increased with an increase in the inter-pin distance as well as an increase in the number of pins. These findings clarified the effect of the number of pins and inter-pin distance for MS on SEFs. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.

DOI

Corticomotor excitability induced by anodal transcranial direct current stimulation with and without non-exhaustive movement

Shota Miyaguchi, Hideaki Onishi, Sho Kojima, Kazuhiro Sugawara, Atsuhiro Tsubaki, Hikari Kirimoto, Hiroyuki Tamaki, Noriaki Yamamoto

Brain Research 1529 83 - 91 2013年09月 [査読有り]

We investigated whether anodal transcranial direct current stimulation (tDCS) applied to the motor cortex during non-exhaustive active or passive movements enhances corticomotor excitability after tDCS or whether it reduces post-exercise depression (PED) after non-exhaustive active or passive movements if PED was observed without tDCS. Nine healthy subjects participated in this study. Anodal tDCS with a current of 2 mA was applied to the left scalp over the primary motor area. All subjects underwent the following five interventions: tDCS delivered for 10 min during relaxation (tDCS condition) and repetitive voluntary and passive finger abduction-adduction movements, each performed without and with tDCS for 10 min (active condition, tDCS+active condition, passive condition, tDCS+passive condition). The active movements were performed at 10% maximum voluntary contraction. Motor evoked potentials (MEPs) were recorded from the right first dorsal interosseus muscle before the intervention (pre-intervention) and 2 and 10 min after the intervention (post-2 min and post-10 min, respectively). Under the tDCS condition, the MEP amplitudes at post-2 and -10 min were significantly increased compared with those before the intervention. Under the active, passive, and tDCS+active conditions, the MEP amplitudes at post-2 min were significantly decreased compared with those before the interventions. Under the tDCS+passive condition, the MEP amplitude remained unchanged. These results demonstrated that anodal tDCS did not reduce PED after active movements but after passive movements and that the anodal tDCS effects were highly dependent on the state of the subject during stimulation. © 2013 Elsevier B.V. All rights reserved.

DOI PubMed

Repeated practice of a Go/NoGo visuomotor task induces neuroplastic change in the human posterior parietal cortex: an MEG study

Kazuhiro Sugawara, Hideaki Onishi, Koya Yamashiro, Toshio Soma, Mineo Oyama, Hikari Kirimoto, Hiroyuki Tamaki, Hiroatsu Murakami, Shigeki Kameyama

EXPERIMENTAL BRAIN RESEARCH ( SPRINGER ) 226 ( 4 ) 495 - 502 2013年05月 [査読有り]

担当区分：筆頭著者 , 責任著者

The posterior parietal cortex (PPC) is strongly related to task performance by evaluating sensory cues and visually guided movements. Sensorimotor processing is improved by task repetition as indicated by reduced response time. We investigated practice-induced changes in PPC visuomotor processing during a Go/NoGo task in humans using 306-channel magnetoencephalography. Eleven healthy adult males were instructed to extend the right index finger when presented with the Go stimulus (a red circle), but not to react to the NoGo stimulus (a green circle or a red square). Magnetic fields over the visual, posterior parietal, and sensorimotor cortices were measured before and after 3 days of task practice. The first peak of the visual-evoked field (VEF) occurred at approximately 80 ms after presentation of either the Go or NoGo stimulus, while a PPC response, with latency to a peak of 175.8 +/- A 26.7 ms, occurred only after the Go stimulus. No significant change in the first peak of VEF was measured after 3 days of task practice, but there was a significant reduction in the latency to peak PPC activity (160.1 +/- A 27.6 ms) and in the time from peak PPC activity to electromyogram onset. In all participants, practice resulted in a significant reduction in reaction time. These results demonstrate that practicing a sensorimotor task induces neuroplastic changes in PPC that accelerate sensorimotor processing and reduce motor response times.

DOI

Modulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation

Sho Kojima, Hideaki Onishi, Kazuhiro Sugawara, Hikari Kirimoto, Makoto Suzuki, Hiroyuki Tamaki

BMC Neuroscience 14 ( 43 ) doi: 10.1186/1471-2202-14-43 2013年04月 [査読有り]

Background: The cortical silent period (CSP) elicited by transcranial magnetic stimulation (TMS) is affected by changes in TMS intensity. Some studies have shown that CSP is shortened or prolonged by short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF), Those studies, however, used different TMS intensities to adjust the amplitude of the motor evoked potential (MEP). Therefore, it is unclear whether changes in CSP duration are induced by changes in TMS intensities or by SICI and ICF. The purpose of this study was to confirm the effects of muscle contractions and stimulus intensities on MEP amplitude and the duration of CSP induced by single-pulse TMS and to clarify the effects of SICI and ICF on CSP duration.MEP evoked by TMS was detected from the right first dorsal interosseous muscle in 15 healthy subjects. First, MEP and CSP were induced by single-pulse TMS with an intensity of 100% active motor threshold (AMT) at four muscle contraction levels [10%, 30%, 50%, and 70% electromyogram (EMG)]. Next, MEP and CSP were induced by seven TMS intensities (100%, 110%, 120%, 130%, 140%, 150%, and 160% AMT) during muscle contraction of 10% EMG. Finally, SICI and ICF were recorded at the four muscle contraction levels (0%, 10%, 30%, and 50% EMG).Results: MEP amplitudes increased with increases in muscle contraction and stimulus intensity. However, CSP duration did not differ at different muscle contraction levels and was prolonged with increases in stimulus intensity. CSP was shortened with SICI compared with CSP induced by single-pulse TMS and with ICF at all muscle contraction levels, whereas CSP duration was not significantly changed with ICF.Conclusions: We confirmed that CSP duration is affected by TMS intensity but not by the muscle contraction level. This study demonstrated that CSP is shortened with SICI, but it is not altered with ICF. These results indicate that after SICI, CSP duration is affected by the activity of inhibitory intermediate neurons that are activated by the conditioning SICI stimulus. © 2013 Kojima et al. licensee BioMed Central Ltd.

DOI PubMed

Neuromagnetic activation following active and passive finger movements

Hideaki Onishi, Kazuhiro Sugawara, Koya Yamashiro, Daisuke Sato, Makoto Suzuki, Hikari Kirimoto, Hiroyuki Tamaki, Hiroatsu Murakami, Shigeki Kameyama

Brain and Behavior 3 ( 2 ) 178 - 192 2013年03月 [査読有り]

The detailed time courses of cortical activities and source localizations following passive finger movement were studied using whole-head magnetoencephalography (MEG). We recorded motor-related cortical magnetic fields following voluntary movement and somatosensory-evoked magnetic fields following passive movement (PM) in 13 volunteers. The most prominent movement-evoked magnetic field (MEF1) following active movement was obtained approximately 35.3 ± 8.4 msec after movement onset, and the equivalent current dipole (ECD) was estimated to be in the primary motor cortex (Brodmann area 4). Two peaks of MEG response associated with PM were recorded from 30 to 100 msec after movement onset. The earliest component (PM1) peaked at 36.2 ± 8.2 msec, and the second component (PM2) peaked at 86.1 ± 12.1 msec after movement onset. The peak latency and ECD localization of PM1, estimated to be in area 4, were the same as those of the most prominent MEF following active movement. ECDs of PM2 were estimated to be not only in area 4 but also in the supplementary motor area (SMA) and the posterior parietal cortex (PPC) over the hemisphere contralateral to the movement, and in the secondary somatosensory cortex (S2) of both hemispheres. The peak latency of each source activity was obtained at 54-109 msec in SMA, 64-114 msec in PPC, and 84-184 msec in the S2. Our results suggest that the magnetic waveforms at middle latency (50-100 msec) after PM are different from those after active movement and that these waveforms are generated by the activities of several cortical areas, that is, area 4 and SMA, PPC, and S2. In this study, the time courses of the activities in SMA, PPC, and S2 accompanying PM in humans were successfully recorded using MEG with a multiple dipole analysis system. © 2013 The Authors. Published by Wiley Periodicals, Inc.

DOI

同側手内筋間および利き手‐非利き手間における皮質中継時間の違い

桐本光, 田巻弘之, 鈴木誠, 菅原和広, 宮口翔太, 大山峰生, 大西秀明

日本生体磁気学会誌 26 ( 1 ) 292 - 293 2013年 [査読有り]

二点識別課題の体性感覚誘発脳磁界

大山峰生, 大西秀明, 相馬俊雄, 菅原和広, 村上博淳, 亀山茂樹

日本生体磁気学会誌 ( 日本生体磁気学会 ) 25 ( 1 ) 194 - 195 2012年06月

機械的皮膚触覚刺激による求心性抑制について

大西秀明, 菅原和広, 小島翔, 田巻弘之, 相馬俊雄, 桐本光, 大山峰生, 山代幸哉, 佐藤大輔, 丸山敦夫, 村上博淳, 亀山茂樹

日本生体磁気学会誌 ( 日本生体磁気学会 ) 25 ( 1 ) 66 - 67 2012年06月

Muscle-afferent projection to the sensorimotor cortex after voluntary movement and motor-point stimulation: An MEG study

Hideaki Onishi, Mineo Oyama, Toshio Soma, Hikari Kirimoto, Kazuhiro Sugawara, Hiroatsu Murakami, Shigeki Kameyama

CLINICAL NEUROPHYSIOLOGY ( ELSEVIER IRELAND LTD ) 122 ( 3 ) 605 - 610 2011年03月 [査読有り]

Objective: To investigate the projection of muscle afferents to the sensorimotor cortex after voluntary finger movement by using magnetoencephalography (MEG). Methods: The movement-evoked magnetic fields (MEFs) after voluntary index-finger extension were recorded by a 204-channel whole-head MEG system. Somatosensory-evoked magnetic fields (SEFs) were recorded after motor-point stimulation was applied to the right extensor indicis muscle by using a pair of wire electrodes. Results: The MEF waveforms were observed at 35.8 +/- 9.7 ms after movement onset (MEF1). The most concentrated SEFs were identified at 78.7 +/- 5.6 ms (M70), and the onset latency of M70 was 39.0 +/- 5.5 ms after motor-point stimulation. The mean locations of the equivalent current dipoles (ECDs) of MEF1 and M70 were significantly medial and superior to that of N20m elicited by median-nerve stimulation. The ECD locations and directions of both MEF1 and M70 were concordant in the axial, coronal and sagittal planes. Conclusions: MEF1 and M70 might be elicited by muscle-afferent feedback following muscle contraction. In addition, these ECDs may be located in area 4. Significance: Motor-point stimulation is a useful tool for confirming the projection of muscle-afferent feedback to the sensorimotor cortex after voluntary movement. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

DOI

　前のページ - 次のページ　

<菅原 和広>

論文 - 菅原 和広

<菅原　和広>

論文 - 菅原　和広