論文 - 長谷川　智一

食道癌生検標本における抗PD-L1抗体の発現

堀 正和, 染谷 正則, 中田 健生, 北川 未央, 土屋 高旭, 長谷川 智一, 福島 悠希, 後町 俊夫, 松本 健一, 坂田 耕一

北海道医学雑誌 ( 北海道医学会 )  92 ( 2 ) 115 - 115  2017年11月

前立腺癌放射線治療患者のリンパ球を用いた消化管および尿路の急性期有害事象予測

染谷 正則, 堀 正和, 長谷川 智一, 中田 健生, 土屋 高旭, 北川 未央, 後町 俊夫, 福島 悠希, 舛森 直哉, 坂田 耕一

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  55回   O7 - 1  2017年10月

Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy.

Masanori Someya, Tomokazu Hasegawa, Masakazu Hori, Yoshihisa Matsumoto, Kensei Nakata, Naoya Masumori, Koh-Ichi Sakata

Journal of radiation research   58 ( 2 ) 225 - 231  2017年03月  [国際誌]

　概要を見る

Repair of DNA damage is critical for genomic stability, and DNA-dependent protein kinase (DNA-PK) has an important role in repairing double-strand breaks. We examined whether the DNA-PK activity of peripheral blood lymphocytes (PBLs) was related to biochemical (prostate-specific antigen: PSA) relapse and radiation toxicity in prostate cancer patients who have received radiotherapy. A total of 69 patients with localized adenocarcinoma of the prostate participated in this study. Peripheral blood was collected 2 years or later after radiotherapy and centrifuged, then DNA-PK activity was measured by a filter binding assay. The high DNA-PK activity group had a significantly higher PSA relapse-free survival rate than the low DNA-PK activity group. The 10-year PSA relapse-free survival was 87.0% in the high DNA-PK activity group, whereas it was 52.7% in the low DNA-PK activity group. Multivariate analysis showed the Gleason score and the level of DNA-PK activity were significant predictors of PSA relapse after radiotherapy. In addition, the low DNA-PK activity group tended to have a higher incidence of Grade 1-2 urinary toxicity than the high DNA-PK activity group. Prostate cancer patients with low DNA-PK activity had a higher rate of PSA relapse and a higher incidence of urinary toxicity. DNA-PK activity in PBLs might be a useful marker for predicting PSA relapse and urinary toxicity, possibly contributing to personalized treatment of prostate cancer.

DOI PubMed

Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy.

Masakazu Hori, Masanori Someya, Yoshihisa Matsumoto, Kensei Nakata, Mio Kitagawa, Tomokazu Hasegawa, Takaaki Tsuchiya, Yuki Fukushima, Toshio Gocho, Yasushi Sato, Hiroyuki Ohnuma, Junji Kato, Shintaro Sugita, Tadashi Hasegawa, Koh-Ichi Sakata

Medical molecular morphology   50 ( 1 ) 25 - 33  2017年03月  [国内誌]

　概要を見る

DNA double-strand break (DSB) is one of the most serious forms of damage induced by ionizing irradiation and is mainly repaired by the non-homologous end joining (NHEJ) repair. Immunohistochemical analysis of proteins involved in NHEJ, such as XRCC4 (X-ray repair cross-complementing protein 4), Ku86 and DNA-PKcs (DNA-dependent protein kinase, catalytic subunits), may be useful for predicting tumor radiosensitivity. We examined 92 patients with esophageal squamous cell carcinoma (ECSS) who were treated by radiotherapy between 1999 and 2008. Immunohistochemical examination of tumor tissue for Ki-67 and DSB-related proteins, including XRCC4, Ku86, and DNA-PKcs, was performed using pretreatment biopsy specimens. Low expression of XRCC4 was detected in 31 of 92 examined samples (33.7 %). The 5-year overall survival (OS) rate was 67.7 % in the low expression group and 31.0 % in the high expression group (P = 0.00). Multivariate analysis confirmed that advanced T-stage (HR 3.24, P = 0.01), radiation dose less than 66 Gy (HR 2.23, P = 0.02), absence of systemic chemotherapy (HR 2.59, P = 0.05), and high expression of XRCC4 (HR 12.0, P = 0.02) were independent prognostic factors for predicting poor OS. Other DSB-related proteins and Ki-67 were not predictive factors. XRCC4 expression might have an influence on results of radiotherapy for patients with ESCC.

DOI PubMed

Influence of Ku86 and XRCC4 expression in uterine cervical cancer on the response to preoperative radiotherapy

Takada Y, Someya M, Matsumoto Y, Satoh M, Nakata K, Hori M, Saito M, Horikawa N, Tateoka K, Teramoto M, Saito T, Hasegawa T, Sakata K

Medical Molecular Morphology.   49 ( 4 ) 210 - 216  2016年02月  [査読有り]

DOI

CRT後出血死に至った頸部食道癌の1例

福島 悠希, 堀 正和, 中田 健生, 染谷 正則, 高田 優, 北川 未央, 長谷川 智一, 後町 俊夫, 松本 健一, 坂田 耕一

Japanese Journal of Radiology ( (公社)日本医学放射線学会 )  34 ( Suppl. ) 11 - 11  2016年02月

頸部食道癌に対するIMRTの治療経験

福島 悠希, 堀 正和, 染谷 正則, 中田 健生, 高田 優, 北川 未央, 長谷川 智一, 後町 俊夫, 坂田 耕一, 大沼 啓之, 佐藤 康史, 加藤 淳二

北海道医学雑誌 ( 北海道医学会 )  90 ( 2 ) 154 - 155  2015年11月

食道癌におけるドセタキセル併用化学放射線治療

堀 正和, 染谷 正則, 中田 健生, 北川 未央, 土屋 高旭, 長谷川 智一, 小野寺 耕一, 坂田 耕一, 佐藤 康史, 大沼 啓之, 加藤 淳二

北海道外科雑誌 ( 北海道外科学会 )  59 ( 2 ) 205 - 205  2014年12月

Intracavitary radiation therapy for patient with isolated vaginal stump recurrence/residual tumor of gynecologic malignancies after radical hysterectomy

K. Nakata, M. Someya, M. Hori, Y. Takada, M. Kitagawa, T. Hasegawa, T. Gochou, K. Sakata

Japanese Journal of Clinical Radiology ( Kanehara Shuppan Co. Ltd )  59 ( 10 ) 1372 - 1378  2014年10月

　概要を見る

This study was a retrospective analysis of 23 patients with vaginal stump recurrence/residual carcinoma after radical hysterectomy for gynecologic malignancies, who were treated by intracavitary radiotherapy at Sapporo Medical University Hospital between 1991 and 2012. Five years overall survival rates and local recurrence free survival rates were 61.3% and 75% in the group of recurrence, and both 100% in the group of residual As for morbidity, no patients received grade 3 or greater late toxicity except only 1 patient grade 3 vaginal mucosal necrosis. Intracavitary radiation therapy provides excellent local control of isolated vaginal stump recurrence/ residual tumor after radical hysterectomy.

子宮全摘術後の腟断端残存/再発腫瘍に対する腔内照射の治療成績

中田 健生, 染谷 正則, 堀 正和, 高田 優, 北川 未央, 長谷川 智一, 後町 俊夫, 坂田 耕一

臨床放射線 ( 金原出版(株) )  59 ( 10 ) 1372 - 1378  2014年10月

　概要を見る

子宮全摘術後の腟断端部残存7例および再発16例に対して腟腔内照射を施行した計23例(中央値62.3歳)の成績を報告した。線源は低線量率(LDR)の137Csが19例、高線量率のremote after roading systemが4例(60Co 1例、192Ir 3例)であった。経過観察期間12〜121ヵ月で、死亡は7例(原病死)、局所再発は術後再発の4例に認め、5年局所制御率は再発例75%、残存例100%、5年生存率はそれぞれ61.3%、100%であった。骨盤部への放射線治療歴があった6例はいずれも重篤な晩期有害事象を認めず、前治療を考慮した照射線量により安全に治療可能であった。晩期有害事象は、LDRの1例が照射後12ヵ月に腟下端に粘膜壊死を伴うgrade 3の粘膜炎を発症したが、保存的な経過観察で21ヵ月後には改善を認めた。その他はgrade 1の直腸出血と両下肢浮腫を各1例に認めた。

当院における中下咽頭癌IMRTの治療成績

中田 健生, 北川 未央, 堀 正和, 長谷川 智一, 三浦 勝利, 染谷 正則, 舘岡 邦彦, 坂田 耕一, 畠中 正光

Japanese Journal of Radiology ( (公社)日本医学放射線学会 )  32 ( Suppl. ) 5 - 5  2014年02月

当科の食道がんに対する放射線治療成績

堀 正和, 中田 健生, 染谷 正則, 高木 克, 三浦 勝利, 北川 未央, 長谷川 智一, 坂田 耕一, 畠中 正光

Japanese Journal of Radiology ( (公社)日本医学放射線学会 )  32 ( Suppl. ) 5 - 5  2014年02月