Details of a Researcher - MARIYA Tasuku

MARIYA Tasuku

写真a

Affiliation	School of Medicine, Department of Obstetrics and Gynecology
Job title	Assistant Professor

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Affiliation 【 display / non-display 】

Fujita Health University 医科学研究センター分子遺伝学研究部門客員助教
Sapporo Medical University Hospital Department of Medial Genetics and Genomics 助教
Sapporo Medical University School of Medicine, Dept.of Obstetrics and Gynecology 助教

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Papers 【 display / non-display 】

Identification and phenotypic characterization of neoantigen-specific cytotoxic CD4+ T cells in endometrial cancer

Minami Fusagawa, Serina Tokita, Kenji Murata, Tasuku Mariya, Mina Umemoto, Shintaro Sugita, Kazuhiko Matsuo, Yoshihiko Hirohashi, Tsuyoshi Saito, Takayuki Kanaseki, Toshihiko Torigoe

Cancer Immunology Research 2024.12

DOI
Impact of colposcopy-guided carbon dioxide laser vaporization therapy on peripheral cervical intraepithelial neoplasia lesions.

Tasuku Mariya, Akira Nishikawa, Mina Umemoto, Shiori Ogawa, Tsuyoshi Saito

Taiwanese journal of obstetrics & gynecology 63 ( 6 ) 846 - 852 2024.11 [International journal]

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OBJECTIVE: Laser vaporization is less invasive than conization for cervical intraepithelial neoplasia (CIN). The outcome of laser vaporization for CIN is empirically known to depend on the colposcopic findings, especially localization of the lesion. In this study, we sought to identify factors involved in the outcome of laser vaporization. MATERIALS AND METHODS: We retrospectively investigated 290 cases of CIN (CIN2, n = 180; CIN3, n = 110) treated with laser evaporation at Nishikawa Women's Health Clinic between 2018 and 2021. All treatments were performed using a carbon dioxide laser under either colposcopic vision (n = 172) or direct vision using a vaginal speculum (n = 118). Risk factors were statistically examined for cure rate after treatment. RESULTS: Multivariate analysis using a logistic regression model identified independent factors affecting the success of treatment to be high-risk human papillomavirus infection status preoperatively, CIN grade, presence of CIN lesions at the periphery of the cervix, and the surgical method used. Colposcopy-guided laser vaporization reduced the risk of treatment failure by 84% (odds ratio 0.16, 95% confidence interval 0.06-0.46; p = 0.001) compared with direct vision using a vaginal speculum. For lesions at the periphery of the cervix, most of the treatment failures were in the group that was not guided by colposcopy (p = 0.031). CONCLUSION: The presence of a peripheral CIN lesion was suggested to be a risk factor for treatment failure. Laser vaporization under colposcopic vision is recommended for treatment of peripheral CIN lesions.

DOI PubMed
Successful Outcome of Stage IB3 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Vaginal Radical Trachelectomy: A Case Report.

Masato Tamate, Motoki Matsuura, Masayuki Someya, Tasuku Mariya, Shinichi Ishioka, Tsuyoshi Saito

Cureus 16 ( 10 ) e71626 2024.10 [International journal]

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Vaginal trachelectomy, which involves resecting the cervix and its parametrium, is a fertility-sparing option for the treatment of early-stage cervical cancer. Although no consensus has been reached on whether simple or radical trachelectomy is preferable, the vaginal approach is typically avoided for tumors larger than 2 cm due to concerns about recurrence. However, some evidence suggests that fertility preservation may still be viable for select patients with larger tumors. This case report describes a woman with bulky cervical cancer who wished to preserve her fertility. After undergoing neoadjuvant chemotherapy (NAC) and vaginal radical trachelectomy (VRT), she achieved a favorable oncological and perinatal outcome, successfully giving birth to a near-full-term baby. The report outlines the patient's management before, during, and after the procedure, including perinatal care. While careful selection of candidates is crucial, accumulating case reports and future trials are expected to shed more light on this treatment approach.

DOI PubMed
Identification of immunogenic HLA class I and II neoantigens using surrogate immunopeptidomes.

Serina Tokita, Minami Fusagawa, Satoru Matsumoto, Tasuku Mariya, Mina Umemoto, Yoshihiko Hirohashi, Fumitake Hata, Tsuyoshi Saito, Takayuki Kanaseki, Toshihiko Torigoe

Science advances 10 ( 38 ) eado6491 2024.09 [International journal]

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Neoantigens arising from somatic mutations are tumor specific and induce antitumor host T cell responses. However, their sequences are individual specific and need to be identified for each patient for therapeutic applications. Here, we present a proteogenomic approach for neoantigen identification, named Neoantigen Selection using a Surrogate Immunopeptidome (NESSIE). This approach uses an autologous wild-type immunopeptidome as a surrogate for the tumor immunopeptidome and allows human leukocyte antigen (HLA)-agnostic identification of both HLA class I (HLA-I) and HLA class II (HLA-II) neoantigens. We demonstrate the direct identification of highly immunogenic HLA-I and HLA-II neoantigens using NESSIE in patients with colorectal cancer and endometrial cancer. Fresh or frozen tumor samples are not required for analysis, making it applicable to many patients in clinical settings. We also demonstrate tumor prevention by vaccination with selected neoantigens in a preclinical mouse model. This approach may benefit personalized T cell-mediated immunotherapies.

DOI PubMed
Microbiological investigation of pregnancies following vaginal radical trachelectomy using 16S rRNA sequencing of FFPE placental specimens.

Risa Tsunematsu, Tasuku Mariya, Mina Umemoto, Shiori Ogawa, Wataru Arai, Suguru E Tanaka, Kyota Ashikawa, Terufumi Kubo, Yoshiyuki Sakuraba, Tsuyoshi Baba, Shinichi Ishioka, Toshiaki Endo, Tsuyoshi Saito

FEBS open bio 2024.09 [International journal]

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This study examined the risk of intrauterine infection associated with radical trachelectomy (RT) in early-stage cervical cancer patients. This procedure preserves fertility but is linked to increased risk of intrauterine infection due to cervical defects during pregnancy. DNA was extracted from the formalin-fixed paraffin-embedded (FFPE) placental specimens of 23 pregnant post-RT patients and 16S rRNA gene sequencing was used for bacterial identification. The prevalence of Lactobacillus crispatus and Burkholderia stabilis was significantly higher in the non-chorioamnionitis group. In contrast, alpha diversity analysis using the PD index showed significantly higher diversity in the chorioamnionitis group (P = 0.04). The demonstrated relationship between chorioamnionitis and microbial diversity affirms the importance of controlling the genital bacterial flora in pregnancies following RT.

DOI PubMed

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Books and Other Publications 【 display / non-display 】

着床前遺伝学的検査<PGT>の最前線と遺伝カウンセリング

倉橋浩樹, 真里谷奨他

メディカルドゥ 2024.01 ISBN: 9784909508263

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Misc 【 display / non-display 】

【産婦人科領域における情報リテラシー-ビッグデータとバイオインフォマティクスの活用】婦人科腫瘍領域におけるAIの活用

梅本美菜, 真里谷奨, 南部優太, 藤野雄一, 鳥越俊彦, 齋藤豪

産婦人科の実際 ( 金原出版(株) ) 73 ( 8 ) 829 - 833 2024.08

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＜文献概要＞AI(人工知能),なかでも深層学習(deep learning)を用いた技術は,医療においても数多くの分野で応用が試みられている。産婦人科領域においてもそれは決して例外ではない。扱う対象データを画像,病理画像や放射線画像,ならびに内視鏡画像に絞ったとしても,多種多様な検討が行われてきた。本稿では,AI全体の潮流についても触れつつ,婦人科腫瘍領域のなかでも特に深層学習を用いた病理診断,細胞診および組織診にまつわるAIの活用について述べる。
当院における類内膜癌G3症例の細胞診・病理形態学的評価と臨床経過の検討

幅田周太朗, 齋藤晋平, 有元千紘, 野藤五沙, 長尾沙智子, 黒川晶子, 玉手雅人, 真里谷奨, 秋元太志, 松浦基樹, 岩崎雅宏, 齋藤豪

日本婦人科腫瘍学会学術講演会プログラム・抄録集 ( (公社)日本婦人科腫瘍学会 ) 66回 327 - 327 2024.07
低置胎盤の分娩管理の変化と,それに伴う周産期転帰の変化について

染谷真行, 古来愛香, 真里谷奨, 馬場剛, 石岡伸一, 齋藤豪

日本周産期・新生児医学会雑誌 ( (一社)日本周産期・新生児医学会 ) 60 ( Suppl.1 ) P382 - P382 2024.06
妊娠中期に多量出血を伴わずに原因不明の産科DICを発症した2例

齋藤晋平, 染谷真行, 真里谷奨, 馬場剛, 石岡伸一, 齋藤豪

日本周産期・新生児医学会雑誌 ( (一社)日本周産期・新生児医学会 ) 60 ( Suppl.1 ) P336 - P336 2024.06
妊娠後期に急性腹症と肝酵素上昇を認め,総胆管結石として待機的管理を行った1例

宮下夕稀子, 染谷真行, 真里谷奨, 馬場剛, 石岡伸一, 岡村直樹, 齋藤豪

日本周産期・新生児医学会雑誌 ( (一社)日本周産期・新生児医学会 ) 60 ( Suppl.1 ) P395 - P395 2024.06

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Awards 【 display / non-display 】

優秀演題賞

2024.09 第56回日本臨床分子形態学会総会・学術集会対照学習とアテンション機構を用いた細胞診断支援におけるExplainable AI構築について

Winner：真里谷奨, 南部優太, 藤野雄一, 齋藤豪他
優秀ポスター演題賞

2024.06 第6回日本メディカルAI学会学術集会子宮内膜がんにおける複数の深層学習アルゴリズムの比較を通した病理組織スライド画像からのMMRステータス推定について

Winner：梅本美菜, 真里谷奨他
優秀演題賞

2024.05 第4回日本遺伝性乳癌卵巣癌総合診療制度機構（JOHBOC）学術総会 54KJPNデータを用いた日本人一般集団におけるBRCA1/2遺伝子の病原性バリアント頻度ならびに病原性解析について

Winner：真里谷奨, 井戸川雅史, 櫻井晃洋, 他
藤本征一郎賞（最優秀演題賞）

2023.12 第25回北海道出生前診断研究会胚培養液中 cell-free lncRNA 発現プロファイルを根拠とした無侵襲着床前胚染色体異数性検査アルゴリズムの構築に関する検討

Winner：真里谷奨, 倉橋浩樹他
最優秀演題賞

2023.10 第100回北海道産科婦人科学会・学術講演会子宮内膜癌分子プロファイルのVirtual screeningシステム創出を目指した病理組織像のAI解析アルゴリズム構築について

Winner：真里谷奨, 梅本美菜, 他

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Research Projects 【 display / non-display 】

胚培養液中cell-freeRNAの解析による異数性胚細胞制御メカニズムの解明

基盤研究(C)

Project Year :

2024.04

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2027.03

真里谷奨
子宮内免疫環境ならびに細菌叢解析に基づく新規子宮内炎症性病態の確立

Project Year :

2023.12

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2025.12

Authorship： Principal investigator
A study of computer aided diagnosis system of cervical cytology using deep learning.

Grant-in-Aid for Scientific Research (C)

Project Year :

2023.04

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2026.03

新開翔太, 鳥越俊彦, 真里谷奨, 藤野雄一, 斉藤豪
深層学習を用いた婦人科細胞診断支援装置の社会実装へ向けた研究

Project Year :

2022.04

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2024.03

Authorship： Principal investigator
北海道周産期・新生児WES・WGS検査解析プラットフォーム確立へ向けた至適実施体制構築に関する基盤的研究

Project Year :

2022.04

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2023.03

Authorship： Principal investigator