Details of a Researcher - MARIYA Tasuku

MARIYA Tasuku

写真a

Affiliation	School of Medicine, Department of Obstetrics and Gynecology
Job title	Assistant Professor

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Affiliation 【 display / non-display 】

Fujita Health University 医科学研究センター分子遺伝学研究部門客員講師
Sapporo Medical University Hospital Department of Medial Genetics and Genomics 講師
Sapporo Medical University School of Medicine, Dept.of Obstetrics and Gynecology 講師

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Papers 【 display / non-display 】

Large number of CD68+/CD163+ Hofbauer cells and characteristic vascular structural alterations in the placental villi of cases with placenta accreta spectrum.

Hazuki Kashiwagi, Kengo Shigehara, Terufumi Kubo, Yoshihiko Hirohashi, Tasuku Mariya, Kazuhiko Matsuo, Tomoyuki Minowa, Shin-Ichi Ishioka, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Tadashi Hasegawa, Tsuyoshi Saito, Toshihiko Torigoe

Medical molecular morphology 2025.03 [Domestic journal]

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Placenta accreta spectrum (PAS) is a serious disease leading to complications and maternal death. The objective of the study was to characterize the placental villi and blood vessels of PAS villi histopathologically. We investigated 10 cases of PAS (five cases of placenta increta, two cases of placenta accreta, and three cases of placenta percreta) histologically. Immunohistochemical staining using anti-CD68 or anti-CD163 antibodies was performed to detect and count Hofbauer cells. Immunohistochemical staining with an anti-CD34 antibody was used to detect vascular endothelial cells, and the number and area of vessels were analyzed. The numbers of CD68-positive or CD163-positive Hofbauer cells were larger in PAS cases compared with control cases. The vascular area in villi was smaller in PAS cases compared with control cases. The number of blood vessels in villi was slightly higher in PAS cases than in control cases. The numbers of Hofbauer cells and vessels in villi were larger in PAS cases compared with control cases, whereas the area of vessels in villi was smaller in PAS cases compared with control cases. Although their biological meaning is elusive, these findings provide novel insights into the pathogenesis of PAS, particularly regarding the role of Hofbauer cells in immune-suppressive role and angiogenesis and the alterations in vascular structure and hemodynamics in the chorionic villi.

DOI PubMed
Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer

Minami Fusagawa, Serina Tokita, Kenji Murata, Tasuku Mariya, Mina Umemoto, Shintaro Sugita, Kazuhiko Matsuo, Yoshihiko Hirohashi, Tsuyoshi Saito, Takayuki Kanaseki, Toshihiko Torigoe

Cancer Immunology Research 2025.02

DOI
Maternal age and the rising incidence of hypertensive disorders of pregnancy: A comprehensive analysis of national claims data from Japan.

Naomi Maeda, Masayuki Koyama, Shintaro Takatsuka, Keisuke Oyatani, Nobuaki Himuro, Tasuku Mariya, Yoshika Kuno, Shiro Hinotsu, Tsuyoshi Saito, Hirofumi Ohnishi

PloS one 20 ( 2 ) e0319177 2025 [International journal]

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BACKGROUND: Hypertensive disorders of pregnancy (HDP) significantly increase the risk of developing hypertension and cardiovascular disease (CVD) later in life and are a major cause of maternal mortality. However, little is known about the nationwide, long-term, all-inclusive status of HDP. OBJECTIVE: To estimate the incidence of HDP from 2011 to 2019 in Hokkaido, Japan, with a focus on age groups. METHODS: Using National Database (NDB) insurance medical data, a retrospective analysis was conducted. Due to the absence of direct pregnancy data, birth numbers were used as a surrogate for the number of pregnant women to calculate the incidence of HDP. RESULTS: The average incidence rate of HDP over 9 years was 6.37%. The incidence rate was lowest among women aged 25-29 years, at 5.58% (95% confidence interval [CI]: 5.43-5.73), and increased with age, peaking at 10.58% (95% CI: 10.10-11.09) among women over 40 years. Notably, the incidence rate for women under 20 years of age was 6.70% (95% CI: 5.97-7.51), which was higher than that for women in their 20s. A mean annual increase of 0.25% in age-adjusted incidence was observed during this period, which was statistically significant (R² = 0.87, p < 0.01). CONCLUSION: This study reveals that the risk of developing HDP is associated with both older childbearing and younger pregnancies and follows a J-curve, suggesting that factors other than maternal aging also contribute to the increased incidence of HDP and that further research on risk factors for HDP, which is on the rise worldwide, is urgently needed.

DOI PubMed
遺伝子関連検査を知る近年のPGT-Mの検査法について

真里谷奨

遺伝子医学 ( (株)メディカルドゥ ) 14 ( 4 ) 101 - 106 2024.12

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PGT-M(preimplantation genetic testing for monogenic/single-gene defects)に用いる胚の生検検体は5～10細胞とごくわずかであり,全ゲノム増幅を経る必要があるため特有の検査上のピットフォールが存在する。そのため,個々の単一遺伝子疾患の確実な検査系の構築はテーラーメイドかつ複雑であるが,ロングリードシーケンサー等の新たなツールの活用により,複雑な構造異常を伴うバリアントやde noveの発端者など,多様な症例にも対応可能となっている。(著者抄録)
Impact of colposcopy-guided carbon dioxide laser vaporization therapy on peripheral cervical intraepithelial neoplasia lesions.

Tasuku Mariya, Akira Nishikawa, Mina Umemoto, Shiori Ogawa, Tsuyoshi Saito

Taiwanese journal of obstetrics & gynecology 63 ( 6 ) 846 - 852 2024.11 [International journal]

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OBJECTIVE: Laser vaporization is less invasive than conization for cervical intraepithelial neoplasia (CIN). The outcome of laser vaporization for CIN is empirically known to depend on the colposcopic findings, especially localization of the lesion. In this study, we sought to identify factors involved in the outcome of laser vaporization. MATERIALS AND METHODS: We retrospectively investigated 290 cases of CIN (CIN2, n = 180; CIN3, n = 110) treated with laser evaporation at Nishikawa Women's Health Clinic between 2018 and 2021. All treatments were performed using a carbon dioxide laser under either colposcopic vision (n = 172) or direct vision using a vaginal speculum (n = 118). Risk factors were statistically examined for cure rate after treatment. RESULTS: Multivariate analysis using a logistic regression model identified independent factors affecting the success of treatment to be high-risk human papillomavirus infection status preoperatively, CIN grade, presence of CIN lesions at the periphery of the cervix, and the surgical method used. Colposcopy-guided laser vaporization reduced the risk of treatment failure by 84% (odds ratio 0.16, 95% confidence interval 0.06-0.46; p = 0.001) compared with direct vision using a vaginal speculum. For lesions at the periphery of the cervix, most of the treatment failures were in the group that was not guided by colposcopy (p = 0.031). CONCLUSION: The presence of a peripheral CIN lesion was suggested to be a risk factor for treatment failure. Laser vaporization under colposcopic vision is recommended for treatment of peripheral CIN lesions.

DOI PubMed

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Books and Other Publications 【 display / non-display 】

着床前遺伝学的検査<PGT>の最前線と遺伝カウンセリング

倉橋浩樹, 真里谷奨他

メディカルドゥ 2024.01 ISBN: 9784909508263

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Misc 【 display / non-display 】

多彩な症状を認めた家族性低カルシウム尿性高カルシウム血症3型の家族例

隅田健太郎, 宮崎幸子, 小松茅乃, 三浦彩奈, 真里谷奨, 石川亜貴, 古橋眞人, 櫻井晃洋

日本内分泌学会雑誌 ( (一社)日本内分泌学会 ) 100 ( 4 ) 805 - 805 2024.12
妊娠初期BVスクリーニング・治療による早産予防は、実臨床では、容易な仕事ではない

島野敏司, 山田俊, 長和俊, 千石一雄, 田村保明, 真里谷奨, 齋藤豪

日本性感染症学会誌 ( (一社)日本性感染症学会 ) 35 ( Suppl. ) 118 - 118 2024.11
【遺伝学的検査Up to Date】遺伝学的検査の応用法を知ろう! 着床前診断を知ろう!

真里谷奨, 倉橋浩樹

小児科診療 ( (株)診断と治療社 ) 87 ( 11 ) 1579 - 1584 2024.11

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＜文献概要＞▽網羅的染色体解析による検査手法の確立により,着床前診断(preimplantation genetic testing:PGT)の診断精度は大きく向上した.▽PGTにまつわる倫理的な議論,特にPGT-M(重篤な遺伝性疾患を対象とした着床前遺伝学的検査)に関連した内容は継続して行われており,検査適応については症例ごとの詳細な検討が必要となる.▽PGTに関連した技術は現在も進歩を続けており,検査の応用範囲は今後さらに拡大していく可能性が高い.
【産婦人科領域における情報リテラシー-ビッグデータとバイオインフォマティクスの活用】婦人科腫瘍領域におけるAIの活用

梅本美菜, 真里谷奨, 南部優太, 藤野雄一, 鳥越俊彦, 齋藤豪

産婦人科の実際 ( 金原出版(株) ) 73 ( 8 ) 829 - 833 2024.08

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＜文献概要＞AI(人工知能),なかでも深層学習(deep learning)を用いた技術は,医療においても数多くの分野で応用が試みられている。産婦人科領域においてもそれは決して例外ではない。扱う対象データを画像,病理画像や放射線画像,ならびに内視鏡画像に絞ったとしても,多種多様な検討が行われてきた。本稿では,AI全体の潮流についても触れつつ,婦人科腫瘍領域のなかでも特に深層学習を用いた病理診断,細胞診および組織診にまつわるAIの活用について述べる。
【産婦人科領域における情報リテラシー-ビッグデータとバイオインフォマティクスの活用】婦人科腫瘍領域におけるAIの活用

梅本美菜, 真里谷奨, 南部優太, 藤野雄一, 鳥越俊彦, 齋藤豪

産婦人科の実際 ( 金原出版(株) ) 73 ( 8 ) 829 - 833 2024.08

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＜文献概要＞AI(人工知能),なかでも深層学習(deep learning)を用いた技術は,医療においても数多くの分野で応用が試みられている。産婦人科領域においてもそれは決して例外ではない。扱う対象データを画像,病理画像や放射線画像,ならびに内視鏡画像に絞ったとしても,多種多様な検討が行われてきた。本稿では,AI全体の潮流についても触れつつ,婦人科腫瘍領域のなかでも特に深層学習を用いた病理診断,細胞診および組織診にまつわるAIの活用について述べる。

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Awards 【 display / non-display 】

JSOG Congress Encouragement Award

2025.05 第77回日本産科婦人科学会学術講演会 Application of long read sequencers for preclinical work up of preimpl antation genetic testing for monogenic/single-gene defects

Winner： Tasuku Mariya, Tsuyoshi Saito, Hiroki Kurahashi
優秀演題賞

2024.09 第56回日本臨床分子形態学会総会・学術集会対照学習とアテンション機構を用いた細胞診断支援におけるExplainable AI構築について

Winner：真里谷奨, 南部優太, 藤野雄一, 齋藤豪他
優秀ポスター演題賞

2024.06 第6回日本メディカルAI学会学術集会子宮内膜がんにおける複数の深層学習アルゴリズムの比較を通した病理組織スライド画像からのMMRステータス推定について

Winner：梅本美菜, 真里谷奨他
優秀演題賞

2024.05 第4回日本遺伝性乳癌卵巣癌総合診療制度機構（JOHBOC）学術総会 54KJPNデータを用いた日本人一般集団におけるBRCA1/2遺伝子の病原性バリアント頻度ならびに病原性解析について

Winner：真里谷奨, 井戸川雅史, 櫻井晃洋, 他
藤本征一郎賞（最優秀演題賞）

2023.12 第25回北海道出生前診断研究会胚培養液中 cell-free lncRNA 発現プロファイルを根拠とした無侵襲着床前胚染色体異数性検査アルゴリズムの構築に関する検討

Winner：真里谷奨, 倉橋浩樹他

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Research Projects 【 display / non-display 】

ロングリードシーケンサーによる新生児・周産期ゲノム解析プラットフォームの構築研究

Project Year :

2025.04

-

2026.03

Authorship： Principal investigator
胚培養液中cell-freeRNAの解析による異数性胚細胞制御メカニズムの解明

基盤研究(C)

Project Year :

2024.04

-

2027.03

真里谷奨
子宮内免疫環境ならびに細菌叢解析に基づく新規子宮内炎症性病態の確立

Project Year :

2023.12

-

2025.12

Authorship： Principal investigator
A study of computer aided diagnosis system of cervical cytology using deep learning.

Grant-in-Aid for Scientific Research (C)

Project Year :

2023.04

-

2026.03

新開翔太, 鳥越俊彦, 真里谷奨, 藤野雄一, 斉藤豪
深層学習を用いた婦人科細胞診断支援装置の社会実装へ向けた研究

Project Year :

2022.04

-

2024.03

Authorship： Principal investigator