Updated on 2025/08/22

写真a

 
MARIYA Tasuku
 
Organization
School of Medicine Department of Obstetrics and Gynecology Assistant Professor
Title
Assistant Professor
ORCID ID
0000-0002-7110-980X
External link

Committee Memberships

  • 日本遺伝カウンセリング学会   用語委員会, 委員長  

    2025.8   

      More details

  • 日本遺伝カウンセリング学会   研修委員会  

    2025.8   

      More details

  • 日本遺伝性腫瘍学会   評議員  

    2025.4   

      More details

    Committee type:Academic society

    researchmap

  • 日本産科婦人科学会   重篤な遺伝性疾患を対象とした着床前遺伝学的検査に関する審査小委員会:担当幹事・委員  

    2024.12   

      More details

    Committee type:Academic society

    researchmap

  • 日本婦人科腫瘍学会   コルポスコピー小委員会, 幹事  

    2024.7   

      More details

  • 日本臨床分子形態学会   評議員  

    2024.6   

      More details

  • 日本周産期・新生児医学会   評議員  

    2024.2   

      More details

    Committee type:Academic society

    researchmap

  • 日本産科婦人科遺伝診療学会   代議員  

    2023.12   

      More details

    Committee type:Academic society

    researchmap

  • 日本人類遺伝学会   評議員  

    2023.10   

      More details

    Committee type:Academic society

    researchmap

  • 日本臨床細胞学会   評議員  

    2023.6   

      More details

  • 日本遺伝カウンセリング学会   編集委員会  

    2021.4 - 2025.7   

      More details

▼display all

Papers

  • Large number of CD68+/CD163+ Hofbauer cells and characteristic vascular structural alterations in the placental villi of cases with placenta accreta spectrum.

    Hazuki Kashiwagi, Kengo Shigehara, Terufumi Kubo, Yoshihiko Hirohashi, Tasuku Mariya, Kazuhiko Matsuo, Tomoyuki Minowa, Shin-Ichi Ishioka, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Tadashi Hasegawa, Tsuyoshi Saito, Toshihiko Torigoe

    Medical molecular morphology   2025.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Placenta accreta spectrum (PAS) is a serious disease leading to complications and maternal death. The objective of the study was to characterize the placental villi and blood vessels of PAS villi histopathologically. We investigated 10 cases of PAS (five cases of placenta increta, two cases of placenta accreta, and three cases of placenta percreta) histologically. Immunohistochemical staining using anti-CD68 or anti-CD163 antibodies was performed to detect and count Hofbauer cells. Immunohistochemical staining with an anti-CD34 antibody was used to detect vascular endothelial cells, and the number and area of vessels were analyzed. The numbers of CD68-positive or CD163-positive Hofbauer cells were larger in PAS cases compared with control cases. The vascular area in villi was smaller in PAS cases compared with control cases. The number of blood vessels in villi was slightly higher in PAS cases than in control cases. The numbers of Hofbauer cells and vessels in villi were larger in PAS cases compared with control cases, whereas the area of vessels in villi was smaller in PAS cases compared with control cases. Although their biological meaning is elusive, these findings provide novel insights into the pathogenesis of PAS, particularly regarding the role of Hofbauer cells in immune-suppressive role and angiogenesis and the alterations in vascular structure and hemodynamics in the chorionic villi.

    DOI: 10.1007/s00795-025-00432-4

    PubMed

    researchmap

  • Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer

    Minami Fusagawa, Serina Tokita, Kenji Murata, Tasuku Mariya, Mina Umemoto, Shintaro Sugita, Kazuhiko Matsuo, Yoshihiko Hirohashi, Tsuyoshi Saito, Takayuki Kanaseki, Toshihiko Torigoe

    Cancer Immunology Research   2025.2

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/2326-6066.CIR-24-0514

    researchmap

  • Maternal age and the rising incidence of hypertensive disorders of pregnancy: A comprehensive analysis of national claims data from Japan. International journal

    Naomi Maeda, Masayuki Koyama, Shintaro Takatsuka, Keisuke Oyatani, Nobuaki Himuro, Tasuku Mariya, Yoshika Kuno, Shiro Hinotsu, Tsuyoshi Saito, Hirofumi Ohnishi

    PloS one   20 ( 2 )   e0319177   2025

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Hypertensive disorders of pregnancy (HDP) significantly increase the risk of developing hypertension and cardiovascular disease (CVD) later in life and are a major cause of maternal mortality. However, little is known about the nationwide, long-term, all-inclusive status of HDP. OBJECTIVE: To estimate the incidence of HDP from 2011 to 2019 in Hokkaido, Japan, with a focus on age groups. METHODS: Using National Database (NDB) insurance medical data, a retrospective analysis was conducted. Due to the absence of direct pregnancy data, birth numbers were used as a surrogate for the number of pregnant women to calculate the incidence of HDP. RESULTS: The average incidence rate of HDP over 9 years was 6.37%. The incidence rate was lowest among women aged 25-29 years, at 5.58% (95% confidence interval [CI]: 5.43-5.73), and increased with age, peaking at 10.58% (95% CI: 10.10-11.09) among women over 40 years. Notably, the incidence rate for women under 20 years of age was 6.70% (95% CI: 5.97-7.51), which was higher than that for women in their 20s. A mean annual increase of 0.25% in age-adjusted incidence was observed during this period, which was statistically significant (R² =  0.87, p <  0.01). CONCLUSION: This study reveals that the risk of developing HDP is associated with both older childbearing and younger pregnancies and follows a J-curve, suggesting that factors other than maternal aging also contribute to the increased incidence of HDP and that further research on risk factors for HDP, which is on the rise worldwide, is urgently needed.

    DOI: 10.1371/journal.pone.0319177

    PubMed

    researchmap

  • 遺伝子関連検査を知る 近年のPGT-Mの検査法について

    真里谷 奨

    遺伝子医学   14 ( 4 )   101 - 106   2024.12

     More details

    Language:Japanese   Publisher:(株)メディカルドゥ  

    Ichushi

    J-GLOBAL

    researchmap

  • 【遺伝学的検査Up to Date】遺伝学的検査の応用法を知ろう! 着床前診断を知ろう!

    真里谷 奨, 倉橋 浩樹

    小児科診療   87 ( 11 )   1579 - 1584   2024.11

  • Impact of colposcopy-guided carbon dioxide laser vaporization therapy on peripheral cervical intraepithelial neoplasia lesions. International journal

    Tasuku Mariya, Akira Nishikawa, Mina Umemoto, Shiori Ogawa, Tsuyoshi Saito

    Taiwanese journal of obstetrics & gynecology   63 ( 6 )   846 - 852   2024.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Laser vaporization is less invasive than conization for cervical intraepithelial neoplasia (CIN). The outcome of laser vaporization for CIN is empirically known to depend on the colposcopic findings, especially localization of the lesion. In this study, we sought to identify factors involved in the outcome of laser vaporization. MATERIALS AND METHODS: We retrospectively investigated 290 cases of CIN (CIN2, n = 180; CIN3, n = 110) treated with laser evaporation at Nishikawa Women's Health Clinic between 2018 and 2021. All treatments were performed using a carbon dioxide laser under either colposcopic vision (n = 172) or direct vision using a vaginal speculum (n = 118). Risk factors were statistically examined for cure rate after treatment. RESULTS: Multivariate analysis using a logistic regression model identified independent factors affecting the success of treatment to be high-risk human papillomavirus infection status preoperatively, CIN grade, presence of CIN lesions at the periphery of the cervix, and the surgical method used. Colposcopy-guided laser vaporization reduced the risk of treatment failure by 84% (odds ratio 0.16, 95% confidence interval 0.06-0.46; p = 0.001) compared with direct vision using a vaginal speculum. For lesions at the periphery of the cervix, most of the treatment failures were in the group that was not guided by colposcopy (p = 0.031). CONCLUSION: The presence of a peripheral CIN lesion was suggested to be a risk factor for treatment failure. Laser vaporization under colposcopic vision is recommended for treatment of peripheral CIN lesions.

    DOI: 10.1016/j.tjog.2024.06.012

    PubMed

    researchmap

  • Successful Outcome of Stage IB3 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Vaginal Radical Trachelectomy: A Case Report. International journal

    Masato Tamate, Motoki Matsuura, Masayuki Someya, Tasuku Mariya, Shinichi Ishioka, Tsuyoshi Saito

    Cureus   16 ( 10 )   e71626   2024.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Vaginal trachelectomy, which involves resecting the cervix and its parametrium, is a fertility-sparing option for the treatment of early-stage cervical cancer. Although no consensus has been reached on whether simple or radical trachelectomy is preferable, the vaginal approach is typically avoided for tumors larger than 2 cm due to concerns about recurrence. However, some evidence suggests that fertility preservation may still be viable for select patients with larger tumors. This case report describes a woman with bulky cervical cancer who wished to preserve her fertility. After undergoing neoadjuvant chemotherapy (NAC) and vaginal radical trachelectomy (VRT), she achieved a favorable oncological and perinatal outcome, successfully giving birth to a near-full-term baby. The report outlines the patient's management before, during, and after the procedure, including perinatal care. While careful selection of candidates is crucial, accumulating case reports and future trials are expected to shed more light on this treatment approach.

    DOI: 10.7759/cureus.71626

    PubMed

    researchmap

  • Identification of immunogenic HLA class I and II neoantigens using surrogate immunopeptidomes. International journal

    Serina Tokita, Minami Fusagawa, Satoru Matsumoto, Tasuku Mariya, Mina Umemoto, Yoshihiko Hirohashi, Fumitake Hata, Tsuyoshi Saito, Takayuki Kanaseki, Toshihiko Torigoe

    Science advances   10 ( 38 )   eado6491   2024.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Neoantigens arising from somatic mutations are tumor specific and induce antitumor host T cell responses. However, their sequences are individual specific and need to be identified for each patient for therapeutic applications. Here, we present a proteogenomic approach for neoantigen identification, named Neoantigen Selection using a Surrogate Immunopeptidome (NESSIE). This approach uses an autologous wild-type immunopeptidome as a surrogate for the tumor immunopeptidome and allows human leukocyte antigen (HLA)-agnostic identification of both HLA class I (HLA-I) and HLA class II (HLA-II) neoantigens. We demonstrate the direct identification of highly immunogenic HLA-I and HLA-II neoantigens using NESSIE in patients with colorectal cancer and endometrial cancer. Fresh or frozen tumor samples are not required for analysis, making it applicable to many patients in clinical settings. We also demonstrate tumor prevention by vaccination with selected neoantigens in a preclinical mouse model. This approach may benefit personalized T cell-mediated immunotherapies.

    DOI: 10.1126/sciadv.ado6491

    PubMed

    researchmap

  • Microbiological investigation of pregnancies following vaginal radical trachelectomy using 16S rRNA sequencing of FFPE placental specimens. International journal

    Risa Tsunematsu, Tasuku Mariya, Mina Umemoto, Shiori Ogawa, Wataru Arai, Suguru E Tanaka, Kyota Ashikawa, Terufumi Kubo, Yoshiyuki Sakuraba, Tsuyoshi Baba, Shinichi Ishioka, Toshiaki Endo, Tsuyoshi Saito

    FEBS open bio   2024.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    This study examined the risk of intrauterine infection associated with radical trachelectomy (RT) in early-stage cervical cancer patients. This procedure preserves fertility but is linked to increased risk of intrauterine infection due to cervical defects during pregnancy. DNA was extracted from the formalin-fixed paraffin-embedded (FFPE) placental specimens of 23 pregnant post-RT patients and 16S rRNA gene sequencing was used for bacterial identification. The prevalence of Lactobacillus crispatus and Burkholderia stabilis was significantly higher in the non-chorioamnionitis group. In contrast, alpha diversity analysis using the PD index showed significantly higher diversity in the chorioamnionitis group (P = 0.04). The demonstrated relationship between chorioamnionitis and microbial diversity affirms the importance of controlling the genital bacterial flora in pregnancies following RT.

    DOI: 10.1002/2211-5463.13892

    PubMed

    researchmap

  • Prediction of Mismatch Repair Status in Endometrial Cancer from Histological Slide Images Using Various Deep Learning-Based Algorithms. International journal

    Mina Umemoto, Tasuku Mariya, Yuta Nambu, Mai Nagata, Toshihiro Horimai, Shintaro Sugita, Takayuki Kanaseki, Yuka Takenaka, Shota Shinkai, Motoki Matsuura, Masahiro Iwasaki, Yoshihiko Hirohashi, Tadashi Hasegawa, Toshihiko Torigoe, Yuichi Fujino, Tsuyoshi Saito

    Cancers   16 ( 10 )   2024.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The application of deep learning algorithms to predict the molecular profiles of various cancers from digital images of hematoxylin and eosin (H&E)-stained slides has been reported in recent years, mainly for gastric and colon cancers. In this study, we investigated the potential use of H&E-stained endometrial cancer slide images to predict the associated mismatch repair (MMR) status. H&E-stained slide images were collected from 127 cases of the primary lesion of endometrial cancer. After digitization using a Nanozoomer virtual slide scanner (Hamamatsu Photonics), we segmented the scanned images into 5397 tiles of 512 × 512 pixels. The MMR proteins (PMS2, MSH6) were immunohistochemically stained, classified into MMR proficient/deficient, and annotated for each case and tile. We trained several neural networks, including convolutional and attention-based networks, using tiles annotated with the MMR status. Among the tested networks, ResNet50 exhibited the highest area under the receiver operating characteristic curve (AUROC) of 0.91 for predicting the MMR status. The constructed prediction algorithm may be applicable to other molecular profiles and useful for pre-screening before implementing other, more costly genetic profiling tests.

    DOI: 10.3390/cancers16101810

    PubMed

    researchmap

  • Correction: The frequency and pathogenicity of BRCA1 and BRCA2 variants in the general Japanese population. International journal

    Masashi Idogawa, Tasuku Mariya, Yumi Tanaka, Tsuyoshi Saito, Hiroshi Nakase, Takashi Tokino, Akihiro Sakurai

    Journal of human genetics   69 ( 5 )   231 - 234   2024.5

     More details

  • Placenta Percreta Progression to Resistance Against Uterine Artery Embolization and Penetration Into the Bladder. International journal

    Yukiko Miyashita, Tasuku Mariya, Masayuki Someya, Shinichi Ishioka, Tsuyoshi Saito

    Cureus   16 ( 3 )   e55651   2024.3

     More details

    Language:English  

    A 31-year-old female sought termination of pregnancy due to a fetal body stalk anomaly diagnosed at 18 weeks of gestation. Despite an anterior placenta previa, successful vaginal delivery occurred. However, placental adhesion over a previous cesarean scar occurred, and part of the placenta could not be removed. Immediate postpartum bleeding prompted imaging studies, revealing extravasation from adherent placental remnants. Uterine artery embolization (UAE) provided initial hemostasis, but recurrent bleeding necessitated re-embolization. Although conservative treatment was initially pursued, significant hematuria prompted reevaluation, revealing extensive uterine wall and bladder penetration. Surgical intervention with total hysterectomy and partial bladder resection was performed, leading to the successful recovery of bladder function following surgical repair. While this case achieved a positive outcome, there is a potential for permanent urinary dysfunction if lesions are more extensive. While achieving a conservative cure is ideal, it is essential to assess the timing for opting for surgical intervention.

    DOI: 10.7759/cureus.55651

    PubMed

    researchmap

  • The frequency and pathogenicity of BRCA1 and BRCA2 variants in the general Japanese population. International journal

    Masashi Idogawa, Tasuku Mariya, Yumi Tanaka, Tsuyoshi Saito, Hiroshi Nakase, Takashi Tokino, Akihiro Sakurai

    Journal of human genetics   83回   J - 1048   2024.2

     More details

    Language:English   Publisher:(一社)日本癌学会  

    DOI: 10.1038/s10038-024-01233-w

    PubMed

    Ichushi

    J-GLOBAL

    researchmap

  • Restoration of ARID1A Protein in ARID1A-deficient Clear Cell Carcinoma of the Ovary Attenuates Reactivity to Cytotoxic T Lymphocytes. International journal

    Risa Tsunematsu, Aiko Murai, Yuka Mizue, Terufumi Kubo, Tasuku Mariya, Rena Morita, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Tsuyoshi Saito, Toshihiko Torigoe

    Cancer genomics & proteomics   21 ( 4 )   414 - 420   2024

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND/AIM: Clear cell carcinoma is a prevalent histological type of ovarian cancer in East Asia, particularly in Japan, known for its resistance to chemotherapeutic agents and poor prognosis. ARID1A gene mutations, commonly found in ovarian clear cell carcinoma (OCCC), contribute to its pathogenesis. Recent data revealed that the ARID1A mutation is related to better outcomes of cancer immunotherapy. Thus, this study aimed to investigate the immunotherapy treatment susceptibility of OCCC bearing ARID1A mutations. MATERIALS AND METHODS: Expression of ARID1A was analyzed using western blotting in ovarian cancer cell lines. OCCC cell lines JHOC-9 and RMG-V were engineered to overexpress NY-ESO-1, HLA-A*02:01, and ARID1A. Sensitivity to chemotherapy and T cell receptor-transduced T (TCR-T) cells specific for NY-ESO-1 was assessed in ARID1A-restored cells compared to ARID1A-deficient wild-type cells. RESULTS: JHOC-9 cells and RMG-V cells showed no expression of ARID1A protein. Overexpression of ARID1A in JHOC-9 and RMG-V cells did not impact sensitivity to gemcitabine. While ARID1A overexpression decreased sensitivity to cisplatin in RMG-V cells, it had no such effect in JHOC-9 cells. ARID1A overexpression reduced the reactivity of NY-ESO-1-specific TCR-T cells, as observed by the IFNγ ESLIPOT assay. CONCLUSION: Cancer immunotherapy is an effective approach to target ARID1A-deficient clear cell carcinoma of the ovary.

    DOI: 10.21873/cgp.20460

    PubMed

    researchmap

  • Pregnancy-specific beta-1-glycoprotein 6 is a potential novel diagnostic biomarker of placenta accreta spectrum.

    Hazuki Kashiwagi, Tasuku Mariya, Mina Umemoto, Shiori Ogawa, Yoshihiko Hirohashi, Yuya Fujibe, Terufumi Kubo, Masayuki Someya, Tsuyoshi Baba, Shinichi Ishioka, Toshihiko Torigoe, Tsuyoshi Saito

    Medical molecular morphology   2023.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Early diagnosis is essential for the safer perinatal management of placenta accreta spectrum (PAS). We used transcriptome analysis to investigate diagnostic maternal serum biomarkers and the mechanisms of PAS development. We analyzed eight formalin-fixed paraffin-embedded placental specimens from two placenta increta and three placenta percreta cases who underwent cesarean hysterectomy at Sapporo Medical University Hospital between 2013 and 2019. Invaded placental regions were isolated from the uterine myometrium and RNA was extracted. The transcriptome difference between normal placenta and PAS was analyzed by microarray analysis. The PAS group showed markedly decreased expression of placenta-specific genes such as LGALS13 and the pregnancy-specific beta-1-glycoprotein (PSG) family. Term enrichment analysis revealed changes in genes related to cellular protein catabolic process, female pregnancy, autophagy, and metabolism of lipids. From the highly dysregulated genes in the PAS group, we investigated the expression of PSG family members, which are secreted into the intervillous space and can be detected in maternal serum from the early stage of pregnancy. The gene expression level of PSG6 in particular was progressively decreased from placenta increta to percreta. The PSG family, especially PSG6, is a potential biomarker for PAS diagnosis.

    DOI: 10.1007/s00795-023-00371-y

    PubMed

    researchmap

  • Endocrinological and Metabolic Heterogeneity is low in Japanese Women with Polycystic Ovary Syndrome. International journal

    Tsuyoshi Baba, Toshiaki Endo, Tasuku Mariya, Yoshika Kuno, Hiroyuki Honnma, Mika Kanaya, Tsuyoshi Saito

    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC   102217 - 102217   2023.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: This study aims to evaluate the endocrine differences among polycystic ovary syndrome (PCOS) phenotypes in Japanese women. METHODS: 118 Japanese women that we diagnosed with PCOS agreed to be included in the study. The study group was classified into the following four phenotypes: A) hyperandrogenism (HA); ovulatory disorder (OvD) and polycystic ovary morphology (PCOM); B) HA and OvD; C) HA and PCOM; and D) OvD and PCOM. We also recruited 66 healthy Japanese women to the study as control participants. Age, body mass index, androgens, luteinizing hormone, follicle-stimulating hormone, and insulin resistance index were evaluated and compared. RESULTS: The proportions of phenotypes A, B, C, and D were 57/120 (47.5%), 4/120 (3.3%), 13/120 (10.8%), and 46/120 (38.3%), respectively. The proportion of phenotype B was too small; therefore, phenotypes A and B were grouped as classical PCOS for intergroup comparisons. The luteinizing hormone/follicle-stimulating hormone ratio in the classical PCOS group was higher than that in the phenotype D group (P < 0.001). Androgen concentrations in the phenotype D group were significantly lower than those in the other groups (P < 0.01). Phenotype D was more common in lean women with PCOS. The surrogate marker of insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR)) was not different irrespective of PCOS and its phenotypes. CONCLUSION: Except for androgens, endocrine differences by PCOS phenotype are not evident, suggesting that diversity among patients with PCOS is relatively low in Japanese women.

    DOI: 10.1016/j.jogc.2023.102217

    PubMed

    researchmap

  • Breakpoints in complex chromosomal rearrangements correspond to transposase-accessible regions of DNA from mature sperm. International journal

    Takeshi Sugimoto, Hidehito Inagaki, Tasuku Mariya, Rie Kawamura, Mariko Taniguchi-Ikeda, Seiji Mizuno, Yukako Muramatsu, Ikuya Tsuge, Hirofumi Ohashi, Nakamichi Saito, Yuiko Hasegawa, Nobuhiko Ochi, Masatoshi Yamaguchi, Jun Murotsuki, Hiroki Kurahashi

    Human genetics   2023.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Constitutional complex chromosomal rearrangements (CCRs) are rare cytogenetic aberrations arising in the germline via an unknown mechanism. Here we analyzed the breakpoint junctions of microscopically three-way or more complex translocations using comprehensive genomic and epigenomic analyses. All of these translocation junctions showed submicroscopic genomic complexity reminiscent of chromothripsis. The breakpoints were clustered within small genomic domains with junctions showing microhomology or microinsertions. Notably, all of the de novo cases were of paternal origin. The breakpoint distributions corresponded specifically to the ATAC-seq (assay for transposase-accessible chromatin with sequencing) read data peak of mature sperm and not to other chromatin markers or tissues. We propose that DNA breaks in CCRs may develop in an accessible region of densely packaged chromatin during post-meiotic spermiogenesis.

    DOI: 10.1007/s00439-023-02591-9

    PubMed

    researchmap

  • Changes in preterm and extremely preterm birth rates in Japan after the introduction of obstetrical practice guidelines in 2008. International journal

    Satoshi Shimano, Takashi Yamada, Kazutoshi Cho, Kazuo Sengoku, Tasuku Mariya, Tsuyoshi Saito

    The journal of obstetrics and gynaecology research   2023.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    AIM: Obstetrical guidelines were established in Japan in 2008, and obstetrical diagnoses and treatments were subsequently standardized nationally. We examined changes in the preterm birth rate (PTBR) and extremely preterm birth rate (EPTBR) following the introduction of such guidelines. METHODS: Information on 50 706 432 live births in Japan between 1979 and 2021, including Japanese reproductive medicine, the childbearing age of pregnant women, and the employment status of reproductive-age women between 2007 and 2020, were obtained from the Japanese government and academic societies. Regression analysis was used to compare chronological changes nationally and those of eight Japanese regions. Regional and national average PTBRs and EPTBRs from 2007 to 2020 were compared by using a repeated measures analysis of variance. RESULTS: From 1979 to 2007, PTBRs and EPTBRs in Japan increased significantly. However, from 2008, the national PTBR and EPTBR decreased until 2020 (p < 0.001) and 2019 (p = 0.02), respectively. From 2007 to 2020, overall PTBR and EPTBR were 5.68% and 0.255%, respectively. A significant difference in the PTBR and EPTBR existed between the eight Japanese regions. During this period, the number of pregnancies using assisted reproductive technology increased from 19 595 to 60 381, pregnant women became older, the employment rate of those of reproductive age increased, and nonregular employment was 54%, which was 2.5 times higher than for men. CONCLUSIONS: In Japan, after obstetrical guidelines were enacted in 2008, PTRBs decreased significantly even under the pressure of increasing preterm births. Countermeasures may be necessary for regions showing high PTBRs.

    DOI: 10.1111/jog.15722

    PubMed

    researchmap

  • Deep learning based presuming for molecular biological profiles of endometrial cancer using digital images of HE-stained specimens

    梅本美菜, 真里谷奨, 永田舞, 堀米俊弘, 新開翔太, 杉田真太朗, 金関貴幸, 松浦基樹, 岩崎雅宏, 廣橋良彦, 長谷川匡, 鳥越俊彦, 齋藤豪, 藤野雄一

    日本医療情報学会春季学術大会プログラム・抄録集   27回   122 - 123   2023.6

     More details

  • Clinical application of long-read nanopore sequencing in a preimplantation genetic testing pre-clinical workup to identify the junction for complex Xq chromosome rearrangement-related disease. International journal

    Tasuku Mariya, Yui Shichiri, Takeshi Sugimoto, Rie Kawamura, Syunsuke Miyai, Hidehito Inagaki, Eiji Sugihara, Keiko Ikeda, Tsuyoshi Baba, Aki Ishikawa, Michiko Ammae, Yoshiharu Nakaoka, Tsuyoshi Saito, Akihiro Sakurai, Hiroki Kurahashi

    Prenatal diagnosis   43 ( 3 )   304 - 313   2023.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Xq chromosome duplication with complex rearrangements is generally acknowledged to be associated with neurodevelopmental disorders such as Pelizaeus-Merzbacher disease (PMD) and MECP2 duplication syndrome. For couples who required a PGT-M (pre-implantation genetic testing for monogenic disease) for these disorders, junction-specific PCR is useful to directly detect pathogenic variants. Therefore, pre-clinical workup for PGT-M requires the identification of the junction of duplicated segments in PMD and MECP2 duplication syndrome, which is generally difficult. METHODS: In this report, we used nanopore long-read sequencing targeting the X chromosome using an adaptive sampling method to identify breakpoint junctions in disease-causing triplications. RESULTS: By long-read sequencing, we successfully identified breakpoint junctions in one PMD case with PLP1 triplication and in another MECP2 triplication case in a single sequencing run. Surprisingly, the duplicated region involving MECP2 was inserted 45 Mb proximal to the original position. This inserted region was confirmed by FISH analysis. With the help of precise mapping of the pathogenic variant, we successfully re-established STR haplotyping for PGT-M and avoided any potential misinterpretation of the pathogenic allele due to recombination. CONCLUSION: Long-read sequencing with adaptive sampling in a PGT-M pre-clinical workup is a beneficial method for identifying junctions of chromosomal complex structural rearrangements. This article is protected by copyright. All rights reserved.

    DOI: 10.1002/pd.6334

    PubMed

    researchmap

  • 深層学習を用いたHE染色からの子宮内膜癌分子生物学的プロファイル推定の適否に関する検討

    梅本 美菜, 真里谷 奨, 新開 翔太, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

    日本産科婦人科学会雑誌   75 ( 臨増 )   S - 260   2023.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • The age-related required number of zygotes estimated from prior clinical studies of preimplantation genetic testing for aneuploidy (PGT-A). International journal

    Tasuku Mariya, Takeshi Sugimoto, Takema Kato, Toshiaki Endo, Hiroki Kurahashi

    Systems biology in reproductive medicine   69 ( 1 )   1 - 7   2023.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Women who are undergoing preimplantation genetic testing for aneuploidy (PGT-A) often wish to know how many eggs will be required to optimize the chances of a live birth. However, no precise data on this can yet be provided during genetic counseling for this procedure. On the basis of PGT-A data from related studies and current databases, we have estimated that the number of zygotes required for a 50% chance of a live birth is 8 at age 40 but increases markedly to 21 at age 43. PGT-A markedly reduces the miscarriage rate per embryo transfer but does not alleviate the extremely high number of zygotes required for a live birth in women of an advanced maternal age. Detailed genetic counseling will therefore be desirable prior to undergoing this procedure.

    DOI: 10.1080/19396368.2022.2151387

    PubMed

    researchmap

  • Letrozole increases preantral follicle growth and decreases estradiol production without impairing follicle survival. International journal

    Fukiko Kasuga-Yamashita, Tsuyoshi Baba, Sachiko Nagao, Yuya Fujibe, Miyuki Morishita, Yoshika Kuno, Tasuku Mariya, Hiroyuki Honnma, Toshiaki Endo, Tamotsu Kiya, Tsuyoshi Saito

    Journal of ovarian research   15 ( 1 )   136 - 136   2022.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Letrozole has been reported to be effective in treating anovulation, preventing ovarian hyperstimulation syndrome (OHSS), and retrieving oocytes in breast cancer patients. However, the role and mechanism of letrozole in follicular development remain unclear. RESULTS: We treated mouse preantral follicles with various treatments; we found no significant difference in follicle survival rates in the letrozole (LET) group compared with the control group, but the average diameter of follicles in the LET group tended to be larger (CTRL vs. LET 30, p = 0.064; CTRL vs. LET 100, p = 0.025). The estradiol concentrations in culture media of the LET group were significantly lower than those observed in the control group (CTRL vs. LET 30, p = 0.038; CTRL vs. LET 100, p = 0.025). We further found a marked increase in follicle-stimulating hormone receptor (FSHR) gene expression in response to letrozole treatment (CTRL vs. LET 30, p = 0.075; CTRL vs. LET 100, p = 0.034). This result suggested that increased FSHR expression promotes follicle development. Letrozole inhibited aromatase activity, but the effect was limited. Letrozole did not significantly reduce vascular endothelial growth factor (VEGF) gene expression. CONCLUSIONS: Letrozole may promote follicle development by increasing the expression of FSHR. Letrozole may be useful for fertility preservation of patients with estrogen-dependent cancers such as breast cancer and various other cancers. Whether letrozole has a direct effect in reducing OHSS requires further investigation.

    DOI: 10.1186/s13048-022-01073-2

    PubMed

    researchmap

  • Maple syrup urine disease due to a paracentric inversion of chr 19 that disrupts BCKDHA: A case report. International journal

    Katsuyuki Yokoi, Yoko Nakajima, Yuta Sudo, Tasuku Mariya, Rie Kawamura, Makiko Tsutsumi, Hidehito Inagaki, Tetsushi Yoshikawa, Tetsuya Ito, Hiroki Kurahashi

    JIMD reports   63 ( 6 )   575 - 580   2022.11

     More details

    Language:English  

    Maple syrup urine disease (MSUD) is a rare autosomal recessive inherited disorder of branched-chain amino acid metabolism caused by mutations in BCKDHA, BCKDHB, and DBT that encode the E1α, E1β, and E2 subunits of the branched-chain α-ketoacid dehydrogenase (BCKD) complex. Various MSUD-causing variants have been described; however, no structural rearrangements in BCKDHA have been reported to cause the classic MSUD phenotype. Here, we describe the classic patient with MSUD with compound heterozygous pathogenic variants in BCKDHA: a missense variant (NM_000709.3:c.757G > A, NP_000700.1:p.Ala253Thr) and a paracentric inversion disrupting Intron 1 of BCKDHA, which was identified by whole-genome sequencing and validated by fluorescence in situ hybridization. Using the sequence information of the breakpoint junction, we gained mechanistic insight into the development of this structural rearrangement. Furthermore, the establishment of junction-specific polymerase chain reaction could facilitate identification of the variant in case carrier or future prenatal/preimplantation tests are necessary.

    DOI: 10.1002/jmd2.12333

    PubMed

    researchmap

  • Target enrichment long-read sequencing with adaptive sampling can determine the structure of the small supernumerary marker chromosomes. International journal

    Tasuku Mariya, Takema Kato, Takeshi Sugimoto, Syunsuke Miyai, Hidehito Inagaki, Tamae Ohye, Eiji Sugihara, Yukako Muramatsu, Seiji Mizuno, Hiroki Kurahashi

    Journal of human genetics   67 ( 6 )   363 - 368   2022.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Structural analysis of small supernumerary marker chromosomes (sSMCs) has revealed that many have complex structures. Structural analysis of sSMCs by whole genome sequencing using short-read sequencers is challenging however because most present with a low level of mosaicism and consist of a small region of the involved chromosome. In this present study, we applied adaptive sampling using nanopore long-read sequencing technology to enrich the target region and thereby attempted to determine the structure of two sSMCs with complex structural rearrangements previously revealed by cytogenetic microarray. In adaptive sampling, simple specification of the target region in the FASTA file enables to identify whether or not the sequencing DNA is included in the target, thus promoting efficient long-read sequencing. To evaluate the target enrichment efficiency, we performed conventional pair-end short-read sequencing in parallel. Sequencing with adaptive sampling achieved a target enrichment at about a 11.0- to 11.5-fold higher coverage rate than conventional pair-end sequencing. This enabled us to quickly identify all breakpoint junctions and determine the exact sSMC structure as a ring chromosome. In addition to the microhomology and microinsertion at the junctions, we identified inverted repeat structure in both sSMCs, suggesting the common generation mechanism involving replication impairment. Adaptive sampling is thus an easy and beneficial method of determining the structures of complex chromosomal rearrangements.

    DOI: 10.1038/s10038-021-01004-x

    PubMed

    researchmap

  • Twin pregnancy with untyped Ehlers-Danlos syndrome requiring prompt genetic testing: A case report. International journal

    Shiori Ogawa, Tasuku Mariya, Yuya Fujibe, Marie Ogawa, Keiko Ikeda, Miyako Mizukami, Yoshika Kuno, Aki Ishikawa, Shinichi Ishioka, Akihiro Sakurai, Tsuyoshi Saito

    Case reports in women's health   33   e00384   2022.1

     More details

    Language:English  

    Ehlers-Danlos syndrome is a rare genetic disorder that presents with a variety of pathologies depending on the disease type. Among them, vascular Ehlers-Danlos syndrome requires extremely careful management as there have been many reports of fatal perinatal complications such as uterine rupture. Although hypermobile Ehlers-Danlos syndrome is less likely to cause fatal complications, symptoms such as arthralgia, hip dislocation, and depression may be seen throughout pregnancy. We report here a case of twin pregnancy in which Ehlers-Danlos syndrome was first suspected at 19 weeks of gestation. Vascular Ehlers-Danlos syndrome could not be ruled out based on family medical history, making it difficult to determine the perinatal management strategy. Prompt genetic testing did however rule out the vascular type and the patient was diagnosed with hypermobile Ehlers-Danlos syndrome from the clinical symptoms, enabling us to manage the pregnancy safely until 34 weeks of gestation.

    DOI: 10.1016/j.crwh.2022.e00384

    PubMed

    researchmap

  • Radical Vaginal Trachelectomy. International journal

    Tsuyoshi Saito, Motoki Matsuura, Masato Tamate, Masahiro Iwasaki, Tasuku Mariya

    Surgery journal (New York, N.Y.)   7 ( Suppl 2 )   S103-S107   2021.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Recently, radical vaginal hysterectomy (RVH) has developed into laparoscopically assisted radical vaginal hysterectomy (LARVH), which is associated with the laparoscopical procedure, and it is applied as radical vaginal trachelectomy and semi-radical vaginal hysterectomy. LARVH is indicated for patients with stage IB1 and IIA1 cervical carcinoma, especially those with a tumor size of less than 2 cm, because the cardinal ligaments cannot be resected widely. Although RVH that is associated with laparoscopic pelvic lymphadenectomy is the most used surgical procedure, radical trachelectomy may be performed either abdominally or vaginally (laparoscopic or robotic). One report found that the pregnancy rate was higher in patients who underwent minimally invasive or radical vaginal trachelectomy than in those who underwent radical abdominal trachelectomy.

    DOI: 10.1055/s-0041-1739120

    PubMed

    researchmap

  • A screening assistance system for cervical cytology of squamous cell atypia based on a two-step combined CNN algorithm with label smoothing. International journal

    Yuta Nambu, Tasuku Mariya, Shota Shinkai, Mina Umemoto, Hiroko Asanuma, Ikuma Sato, Yoshihiko Hirohashi, Toshihiko Torigoe, Yuichi Fujino, Tsuyoshi Saito

    Cancer medicine   11 ( 2 )   520 - 529   2021.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Although many cervical cytology diagnostic support systems have been developed, it is challenging to classify overlapping cell clusters with a variety of patterns in the same way that humans do. In this study, we developed a fast and accurate system for the detection and classification of atypical cell clusters by using a two-step algorithm based on two different deep learning algorithms. METHODS: We created 919 cell images from liquid-based cervical cytological samples collected at Sapporo Medical University and annotated them based on the Bethesda system as a dataset for machine learning. Most of the images captured overlapping and crowded cells, and images were oversampled by digital processing. The detection system consists of two steps: (1) detection of atypical cells using You Only Look Once v4 (YOLOv4) and (2) classification of the detected cells using ResNeSt. A label smoothing algorithm was used for the dataset in the second classification step. This method annotates multiple correct classes from a single cell image with a smooth probability distribution. RESULTS: The first step, cell detection by YOLOv4, was able to detect all atypical cells above ASC-US without any observed false negatives. The detected cell images were then analyzed in the second step, cell classification by the ResNeSt algorithm, which exhibited average accuracy and F-measure values of 90.5% and 70.5%, respectively. The oversampling of the training image and label smoothing algorithm contributed to the improvement of the system's accuracy. CONCLUSION: This system combines two deep learning algorithms to enable accurate detection and classification of cell clusters based on the Bethesda system, which has been difficult to achieve in the past. We will conduct further research and development of this system as a platform for augmented reality microscopes for cytological diagnosis.

    DOI: 10.1002/cam4.4460

    PubMed

    researchmap

  • Next-generation sequencing of 16S rRNA for identification of invasive bacterial pathogens in a formalin-fixed paraffin-embedded placental specimen: a case report of perinatal fulminant Streptococcus pyogenes infection.

    Tasuku Mariya, Toyotaka Sato, Yuya Fujibe, Manami Ishido, Hiroshi Shimada, Terufumi Kubo, Yoko Nagai, Wataru Arai, Suguru E Tanaka, Kyota Ashikawa, Yoshiyuki Sakuraba, Shinichi Ishioka, Shin-Ichi Yokota, Tsuyoshi Saito

    Medical molecular morphology   54 ( 4 )   374 - 379   2021.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Intrauterine infection is one of the most important causes of maternal death. In perinatal emergency, we often miss an opportunity to obtain culture specimens. In this study, we tried to examine whether we investigated whether bacteria causing infection can be detected from a formalin-fixed paraffin-embedded (FFPE) placental specimen. We examined the placenta from a maternal invasive infection that resulted in infectious abortion at 18 weeks of gestation. The case was diagnosed by acute fever and abdominal pain, and the patient was cured after 3 weeks of intensive antimicrobial treatment. Four Streptococcus pyogenes strains were isolated from vaginal fluid and blood cultures of the patient. All of the strain types were emm1/ST28. We amplified the V1-V2 region of 16S rRNA from an FFPE placental specimen and sequencing was performed using a next-generation sequencer (NGS). Taxonomic analysis was then performed for sequenced data. We succeeded in detecting causative pathogens from the FFPE placenta: 69.1% of the predominantly identified bacteria were S. pyogenes and other small populations of bacteria were detected. Our results revealed the utility of NGS for 16S rRNA analysis of an FFPE placenta. This method may reveal previous perinatal invasive infections of unknown origin retrospectively.

    DOI: 10.1007/s00795-021-00298-2

    PubMed

    researchmap

  • Effectiveness of cross double mcdonald cerclage for intractable bleeding from a cervical varix in pregnant women

    Yuya Fujibe, Tasuku Mariya, Masahito Mizuuchi, Shinichi Ishioka, Tsuyoshi Saito

    Gynecology and Minimally Invasive Therapy   10 ( 3 )   177 - 180   2021.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wolters Kluwer Medknow Publications  

    DOI: 10.4103/GMIT.GMIT_74_20

    researchmap

  • 子宮温存している若年発症子宮体部腺肉腫の2例

    寺田 倫子, 松浦 基樹, 野藤 五沙, 西村 庸子, 真里谷 奨, 玉手 雅人, 岩崎 雅宏, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   292 - 292   2021.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    J-GLOBAL

    researchmap

  • Increased cervical Chlamydia trachomatis and syphilis infections in Japanese females of reproductive age in the late 2010s: Possible cause. International journal

    Satoshi Shimano, Tasuku Mariya, Tsuyoshi Saito

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    From 2000 to 2019, Japan's reproductive-age population gradually declined by 24%. In comparison, the Chlamydia trachomatis infection rate increased from 2016, with the syphilis infection rate increasing more sharply from 2014. Since 2013, the numbers of foreign tourists to Japan have also increased. From 2011 to 2018, the rate of increase in tourists was 5.02 times, while the rate of increase in syphilis patients was higher at 22.4 times. The lack of a one-to-one relationship between foreign tourists and syphilis cases suggests that cases of syphilis were transmitted to others. Although the prevalence of syphilis in the tourists' home countries (Korea in 2014 and China in 2013) was 20-30 times higher than that in Japan, the Japanese sex industry did not discriminate against foreign tourists, leading to increased STI infections in Japanese female sex workers. Indeed, from 2017 to 2018, a history of working in the sex industry for six months was identified as a risk factor for syphilis. The rise in Chlamydia trachomatis infections has lagged behind that of syphilis by two years, with the rate of increase lower. We suspect the difference in increasing rates of syphilis and chlamydial infections is due to the different methods of infection: syphilis can be transmitted by light physical contact, such as a kiss, whereas chlamydia requires close sexual contact, such as oral sex or sexual intercourse. Regardless, examinations and infection control are necessary to prevent the spread of STIs in Japan due to inbound tourists.

    DOI: 10.1016/j.jiac.2021.05.015

    PubMed

    researchmap

  • Does Radical trachelectomy (RT) during pregnancy have higher obstetrical and oncological risks than RT before pregnancy?

    Shota Shinkai, Shinichi Ishioka, Tasuku Mariya, Yuya Fujibe, Miseon Kim, Masayuki Someya, Tsuyoshi Saito

    2021.3

     More details

    Publisher:Research Square Platform LLC  

    <title>Abstract</title>
    Purpose

    Radical trachelectomy (RT) with pelvic lymphadenectomy has become a new treatment option for young patients with uterine cervical cancer stages 1A2–1B1 who desire the preservation of their fertility. However, the application of RT for pregnant patients is still controversial. We comparatively studied both obstetrical and oncological outcomes of pregnant patients who underwent vaginal RT during pregnancy and those who underwent vaginal RT before pregnancy.
    Methods

    Both obstetrical and oncological results of eight patients who underwent vaginal RT with pelvic lymphadenectomy during pregnancy in our institute between 2010 and 2020 (Group A), and ten pregnant patients who underwent vaginal RT with pelvic lymphadenectomy before pregnancy during the same period (Group B) were reviewed based on their medical charts.
    Results

    There were no significant differences in blood loss, surgical time, or surgical completeness between Group A and Group B. Nor were there significant differences in obstetrical outcomes between the two groups. However, two of the eight patients in Group A had recurrence of the cancer. None of the patients in Group B has shown any signs of recurrence thus far.
    Conclusion

    Vaginal RT during pregnancy does not affect the obstetrical prognoses of patients with early invasive uterine cervical cancer, and it might be a tolerable treatment modality for them. However, oncologically, it should be performed carefully as there is a risk of recurrence.

    Other Link: https://www.researchsquare.com/article/rs-228984/v1.html

    DOI: 10.21203/rs.3.rs-228984/v1

    researchmap

  • Common iliac artery dissection as a complication of common iliac artery balloon occlusion for placenta percreta: A case report. International journal

    Kimihito Saito, Tasuku Mariya, Yuya Fujibe, Masato Saito, Naoki Hirokawa, Shinichi Ishioka, Tsuyoshi Saito

    The journal of obstetrics and gynaecology research   47 ( 3 )   1172 - 1177   2021.3

     More details

    Language:English  

    A 37-year-old pregnant woman who had undergone three previous cesarean sections was diagnosed as having placenta percreta. We decided to perform cesarean hysterectomy with bilateral common iliac artery balloon occlusion (CIABO). The duration of surgery was 2 h and 2 min and total estimated blood loss was 2600 mL. Surgery was completed without any surgical complications, but the pulse oximeter waveform of the left leg became undetectable during surgery. We immediately performed angiography after closure of laparotomy and found abnormal pooling of contrast media at the left common iliac artery in the region in which the balloon was positioned. We made a diagnosis of left common iliac artery dissection caused by CIABO. We performed emergent revascularization by intravascular stenting. We conclude that CIABO can cause common iliac artery dissection by mechanical stimulation of the inflated balloon. Careful intraoperative evaluation of limb ischemia and preparation of intravascular treatment is needed for a safe procedure.

    DOI: 10.1111/jog.14601

    PubMed

    researchmap

  • Less correlation between mismatch repair proteins deficiency and decreased expression of HLA class I molecules in endometrial carcinoma: a different propensity from colorectal cancer.

    Tasuku Mariya, Terufumi Kubo, Yoshihiko Hirohashi, Junko Yanagawa, Yuta Tabuchi, Kazuhiko Matsuo, Kiyoshi Furumura, Rena Morita, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Tadashi Hasegawa, Tsuyoshi Saito, Toshihiko Torigoe

    Medical molecular morphology   54 ( 1 )   14 - 22   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Mismatch repair protein deficiency (dMMR) is a favorable prognostic factor in colorectal cancer. It is also associated with aberrant expression of HLA class I molecules, which are required for cytotoxic T lymphocyte-mediated cancer immunotherapy. Because dMMR is frequently also found in endometrial cancers (ECs), we retrospectively investigated the expression of mismatch repair proteins and HLA class I molecules in 127 EC patients. In this study, EC patients being treated in our hospital were recruited from 2005 to 2009 and observed until December 2017. Lesion specimens were evaluated via immunohistochemistry for MSH6 and PMS2 (mismatch repair proteins) and HLA class I molecules. Expression of these molecules was statistically related to clinical and pathological factors and prognosis. dMMR was detected in 33 patients and did not correlate with the expression level of HLA class I molecules (P = 0.60). On the other hand, unexpectedly, multivariate analysis revealed that intact expression of HLA class I molecules was associated with p53 overexpression (P = 0.004). Neither dMMR nor decreased expression of HLA class I molecules were prognostic factors. These results are inconsistent with previous findings for colorectal cancer. A distinctive local tissue immune microenvironment would underlie the discrepancy in the results between EC and colorectal cancer.

    DOI: 10.1007/s00795-020-00254-6

    PubMed

    researchmap

  • Umbilical cyst associated with patent urachus that spontaneously disappeared: A case report. International journal

    Yuya Fujibe, Tasuku Mariya, Masahito Mizuuchi

    Prenatal diagnosis   41 ( 3 )   384 - 385   2021.2

     More details

    Language:English  

    DOI: 10.1002/pd.5889

    PubMed

    researchmap

  • 【産婦人科感染症の最新知見】注目されている産婦人科感染症 細菌性腟症、性器クラミジア感染症

    島野 敏司, 真里谷 奨, 長井 陽子, 芦川 享大, 荒井 渉, 斎藤 豪

    臨床と微生物   48 ( 1 )   041 - 045   2021.1

     More details

    Language:Japanese   Publisher:(株)近代出版  

    Ichushi

    researchmap

  • 骨盤解剖学をCadaver Surgery Trainingで理解する混合研究の試み

    玉手 雅人, 松浦 基樹, 阿部 秀悦, 西村 庸子, 常松 梨沙, 寺田 倫子, 真里谷 奨, 岩崎 雅宏, 金尾 祐之, 齋藤 豪

    日本婦人科腫瘍学会雑誌   39 ( 1 )   311 - 311   2021.1

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • ERα increases endometrial cancer cell resistance to cisplatin via upregulation of BAG3. International journal

    Shuetsu Abe, Masahiro Iwasaki, Shutaro Habata, Tasuku Mariya, Masato Tamate, Motoki Matsuura, Seiro Satohisa, Tsuyoshi Saito

    Oncology letters   21 ( 1 )   20 - 20   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Endometrial cancer is a leading cause of cancer-associated mortality in women and has a poor prognosis in advanced stages. Our previous study revealed that BCL-2-associated athanogene 3 (BAG3) may contribute to enhancing cell viability through downregulation of microRNA (miR)-29b in endometrial cancer cell lines. In addition, a relationship between estrogen receptor α (ERα) and BAG3 was recently reported in several cancer cell types. The present study investigated the relationship between ERα and BAG3 in endometrial cancer cell lines. The results demonstrated that exogenous ERα overexpression enhanced BAG3 expression in the EMTOKA endometrial cancer cell line, which does not endogenously express ERα, but had no effect on BAG3 expression levels in the Ishikawa cell line, which does endogenously express ERα. In addition, ERα overexpression suppressed miR-29b expression and enhanced the expression of Mcl-1, a mediator situated downstream of BAG3, in EMTOKA cells, but not Ishikawa cells. ERα overexpression also enhanced EMTOKA, but not Ishikawa, endometrial cancer cell viability in the presence of cisplatin. These findings suggested that ERα may contribute to enhancing endometrial cancer cell resistance to anticancer agents through BAG3 overexpression.

    DOI: 10.3892/ol.2020.12281

    PubMed

    researchmap

  • Deep Learning(YOLOv3)を用いたリアルタイム婦人科細胞診断支援システム設計の試み

    真里谷 奨, 新開 翔太, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 南部 優太, 藤野 雄一, 淺沼 広子, 廣橋 良彦, 鳥越 俊彦, 齋藤 豪

    日本婦人科腫瘍学会雑誌   39 ( 1 )   278 - 278   2021.1

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • ERα発現および非発現子宮体癌細胞株に於けるBAG3発現および増殖能との関連

    阿部 秀悦, 岩崎 雅宏, 幅田 周太朗, 真里谷 奨, 小川 万梨絵, 郷久 晴朗, 齋藤 豪

    日本婦人科腫瘍学会雑誌   39 ( 1 )   285 - 285   2021.1

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 腹腔鏡下子宮筋腫核出術後に発生したparasitic myomaの1例

    岩崎 雅宏, 真里谷 奨, 阿部 秀悦, 松浦 基樹, 玉手 雅人, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 196]   2020.11

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 胎児期に診断に苦慮した先天性嚢胞状腺腫様形成異常に胸腔外肺分画症を合併した一例

    染谷 真行, 古来 愛香, 新開 翔太, 真里谷 奨, 石岡 伸一, 齋藤 豪

    超音波医学   47 ( Suppl. )   S418 - S418   2020.11

     More details

    Language:Japanese   Publisher:(公社)日本超音波医学会  

    Ichushi

    researchmap

  • 深層学習を用いた子宮頸部細胞診人工知能診断支援システムの有用性について

    真里谷 奨, 南部 優太, 淺沼 広子, 廣橋 良彦, 岩崎 雅宏, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

    日本癌学会総会記事   79回   OJ15 - 7   2020.10

     More details

    Language:English   Publisher:(一社)日本癌学会  

    Ichushi

    J-GLOBAL

    researchmap

  • Cadaver Surgery Trainingの壁を超える意義

    玉手 雅人, 松浦 基樹, 西村 庸子, 真里谷 奨, 磯山 響子, 寺田 倫子, 郷久 晴朗, 岩崎 雅宏, 齋藤 豪

    産婦人科手術   ( 31 )   189 - 189   2020.8

     More details

    Language:Japanese   Publisher:(株)メジカルビュー社  

    Ichushi

    researchmap

  • 当院婦人科領域におけるBRCA遺伝子検査状況の変化

    真里谷 奨, 寺田 倫子, 宮崎 幸子, 石川 亜貴, 岩崎 雅宏, 齋藤 豪, 櫻井 晃洋

    日本遺伝カウンセリング学会誌   41 ( 2 )   75 - 75   2020.6

     More details

    Language:Japanese   Publisher:日本遺伝カウンセリング学会  

    Ichushi

    researchmap

  • Deep Learning(YOLO)を用いた子宮頸部細胞診診断支援の有用性

    新開 翔太, 真里谷 奨, 郷久 晴朗, 岩崎 雅宏, 南部 優太, 藤野 雄一, 淺沼 広子, 廣橋 良彦, 鳥越 俊彦, 齋藤 豪

    日本臨床細胞学会雑誌   59 ( Suppl.1 )   207 - 207   2020.5

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • Transabdominal cerclage (TAC) as a new tool for the treatment of cervical incompetence (CI). International journal

    Shinichi Ishioka, Tasuku Mariya, Masayuki Someya, Tsuyoshi Saito

    Annals of translational medicine   8 ( 9 )   571 - 571   2020.5

     More details

  • 妊娠中の広汎子宮頸部摘出術(RT)後子宮頸部細胞診における異型細胞の出現

    石岡 伸一, 真里谷 奨, 金 美善, 新開 翔太, 齋藤 豪

    日本臨床細胞学会雑誌   59 ( Suppl.1 )   232 - 232   2020.5

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • 開腹子宮頸部縫縮術(TAC)後妊娠初期流産症例に対するmethotrexate(MTX)療法の一例

    石堂 茉泉, 石岡 伸一, 藤部 佑哉, 鈴木 美紀, 嶋田 浩志, 真里谷 奨, 馬場 剛, 齋藤 豪

    日本周産期・新生児医学会雑誌   56 ( 1 )   198 - 202   2020.5

  • 【専門医はもういらない? せまりくるAI時代】AIによる病理組織診断支援

    真里谷 奨, 久保 輝文, 齋藤 豪, 鳥越 俊彦

    産婦人科の実際   69 ( 5 )   463 - 468   2020.5

  • Pregnancies after vaginal radical trachelectomy (RT) in patients with early invasive uterine cervical cancer: results from a single institute. International journal

    Shota Shinkai, Shinichi Ishioka, Tasuku Mariya, Yuya Fujibe, Miseon Kim, Masayuki Someya, Tsuyoshi Saito

    BMC pregnancy and childbirth   20 ( 1 )   248 - 248   2020.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Radical tracheletomy (RT) with pelvic lymphadenectomy has become an option for young patients with early invasive uterine cervical cancer who desire to maintain their fertility. However, this operative method entails a high risk for the following pregnancy due to its radicality. METHODS: We have performed vaginal RT for 71 patients and have experienced 28 pregnancies in 21 patients. They were followed up carefully according to the follow-up methods we reported previously. Their pregnancy courses and prognoses after the pregnancy were retrospectively reviewed. RESULTS: All the vaginal RTs were performed safely without serious complications, including 6 patients who underwent the operation during pregnancy. The median time to be pregnant after RT was 29.5 months. 13 patients (46%) became pregnant without artificial insemination by husband or assisted reproductive technology. Cesarean section was performed for all of them. The median time of pregnancy was 34 weeks, and emergent cesarean section was performed for 7 pregnancies (25%). The median birth weight was 2156 g. Four patients had trouble with cervical cerclage, and they suffered from sudden premature preterm rupture of the membrane (pPROM) during the second trimester of pregnancy. We underwent transabdominal cerclage (TAC) for all of them and careful management for the prevention of uterine infection was performed. One patient had a recurrence of cancer during pregnancy. CONCLUSIONS: Both the obstetrical prognosis and oncological prognosis after vaginal RT have become favorable for pregnant patients after vaginal RT.

    DOI: 10.1186/s12884-020-02949-1

    PubMed

    researchmap

  • 妊娠中の広汎子宮頸部全摘出術 腟式トラケレクトミー

    齋藤 豪, 岩崎 雅宏, 松浦 基樹, 玉手 雅人, 真里谷 奨, 石岡 伸一

    日本婦人科腫瘍学会雑誌   38 ( 2 )   145 - 150   2020.4

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • 女性診療科として考えるライフステージごとの尿路感染症

    真里谷 奨, 齋藤 豪, 高橋 聡

    感染症学雑誌   94 ( 2 )   219 - 220   2020.3

     More details

    Language:Japanese   Publisher:(一社)日本感染症学会  

    Ichushi

    researchmap

  • 子宮頸がんにおける当院のVaginal Trachelectomyの成績と意義

    玉手 雅人, 松浦 基樹, 黒川 晶子, 西村 庸子, 磯山 響子, 寺田 倫子, 真里谷 奨, 岩崎 雅宏, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   72 ( 臨増 )   S - 359   2020.3

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 難治性尿路感染症に隠れたものは? 女性診療科として考えるライフステージごとの尿路感染症

    真里谷 奨, 齋藤 豪, 高橋 聡

    日本化学療法学会雑誌   68 ( 2 )   246 - 246   2020.3

     More details

    Language:Japanese   Publisher:(公社)日本化学療法学会  

    Ichushi

    researchmap

  • Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency. International journal

    Yuya Fujibe, Tasuku Mariya, Masahito Mizuuchi, Shinichi Ishioka, Masahiro Yoshida, Tsuyoshi Saito

    Taiwanese journal of obstetrics & gynecology   58 ( 6 )   849 - 851   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency. CASE REPORT: A 30-year-old woman, gravida 2 para 0, was referred to our hospital because of AT deficiency. Unfractionated heparin was administered from 13 weeks of gestation and rhAT was administered from labor onset. A cesarean section was performed and the patient and her baby were healthy, with no sequelae. CONCLUSION: We concluded that rhAT was effective for preventing VTE during delivery, with no potential infection risks.

    DOI: 10.1016/j.tjog.2019.09.021

    PubMed

    researchmap

  • 転移性女性生殖器がんにおける臨床像と捺印細胞像

    玉手 雅人, 松浦 基樹, 長尾 沙智子, 西村 庸子, 真里谷 奨, 寺田 倫子, 郷久 晴朗, 杉田 真太朗, 岩崎 雅宏, 齋藤 豪

    日本臨床細胞学会雑誌   58 ( Suppl.2 )   601 - 601   2019.10

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • 当科において妊娠初期子宮頸部細胞診HSIL/ASC-H以上を認めた症例の検討

    真里谷 奨, 石岡 伸一, 玉手 雅人, 郷久 晴朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

    日本臨床細胞学会雑誌   58 ( Suppl.2 )   587 - 587   2019.10

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • 重症子宮内膜症を有する不妊治療における手術とART介入のタイミング

    森下 美幸, 長尾 沙智子, 新開 翔太, 久野 芳佳, 真里谷 奨, 馬場 剛, 遠藤 俊明, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   252 - 252   2019.8

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    researchmap

  • Obstetrical prognosis of patients who underwent vaginal radical trachelectomy during pregnancy. International journal

    Mina Umemoto, Shinichi Ishioka, Yuko Mizugaki, Yuya Fujibe, Tasuku Mariya, Akari Kawamata, Masahito Mizuuchi, Miyuki Morishita, Tsuyoshi Baba, Tsuyoshi Saito

    The journal of obstetrics and gynaecology research   45 ( 6 )   1167 - 1172   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    AIM: Radical trachelectomy (RT) with pelvic lymphadenectomy has become an option for young patients with early invasive uterine cervical cancer who decide to maintain their fertility. However, this operative method entails a high risk for the following pregnancy due to its radicality. Therefore, RT for pregnant patients can be a challenge both for gynecologic oncologists and obstetricians. METHODS: We have performed vaginal RT for five pregnant patients with uterine cervical cancer stage 1B1 according to the method of Dargent et al. The operations were performed between 16 and 26 weeks of pregnancy, and the patients were followed up carefully according to the follow-up methods we reported previously. RESULTS: Vaginal RT was performed for five patients without any troubles. Four of the patients continued their pregnancies until almost 34 weeks or longer under our previously published follow-up schedule. The pregnancy of one patient was terminated at 26 weeks due to recurrence of the cancer. CONCLUSION: Expansion of vaginal RT for pregnant patients with uterine cervical cancer could be a practical option for pregnant patients with early invasive uterine cervical cancer.

    DOI: 10.1111/jog.13964

    PubMed

    researchmap

  • Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma. International journal

    Yuta Tabuchi, Yoshihiko Hirohashi, Shinichi Hashimoto, Tasuku Mariya, Takuya Asano, Kazuho Ikeo, Takafumi Kuroda, Masahito Mizuuchi, Aiko Murai, Sei Uno, Noriko Kawai, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Tsuyoshi Saito, Toshihiko Torigoe

    Experimental and molecular pathology   106   78 - 88   2019.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Uterine endometrial carcinoma is one of the common cancers in females. Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) are a small subpopulation of cancer cells that are tumorigenic and are resistant to treatments, thus they are focused as treatment targets. However, the heterogeneity of CSCs/CICs is still elusive, and we therefore analyzed CSCs/CICs at the clonal level. We previously established sphere-cultured CSCs/CICs from primary human uterine endometrial carcinoma, and we isolated several clones from CSCs/CICs in this study. Interestingly, we established two types of clones based on the growth pattern. The clones were termed sphere clones (S clones) and leukemia-like clones (LL clones). Functional analysis revealed that S clones are resistant to chemotherapy, whereas LL clones are sensitive to chemotherapy. On the other hand, S clones are less tumorigenic, while LL clones are highly tumorigenic. Transcriptome analysis using serial analysis of gene expression sequencing (SAGE-Seq) revealed distinctive gene expression profiles in S clone cells and LL clone cells. The results indicate that CSCs/CICs are composed of functionally heterogenic subpopulations including highly tumorigenic clones and treatment-resistant clones and that the characteristics of CSCs/CICs might be determined by the characteristics of different clones that compose CSCs/CICs.

    DOI: 10.1016/j.yexmp.2018.11.013

    PubMed

    researchmap

  • Recurrent Massive Uterine Bleeding from a Cesarean Scar Treated Successfully by Laparoscopic Surgery. International journal

    Tasuku Mariya, Mina Umemoto, Naoko Sugita, Masahiro Suzuki, Tsuyoshi Saito

    Gynecology and minimally invasive therapy   8 ( 1 )   36 - 39   2019

     More details

    Language:English  

    A cesarean scar can cause abnormal uterine bleeding including prolonged menstruation or postmenstrual spotting. Our patient showed massive uterine bleeding from a cesarean scar and needed blood transfusion for hemorrhagic shock. A cesarean section had only been performed once for delivery stop 9 years ago. Recurrent hemorrhage could not be controlled by conservative treatment, and we performed laparoscopic scar resection and repair. The abnormal uterine bleeding was successfully stopped, and the menstrual cycle was normalized after surgical treatment. We should be aware that even an uneventful cesarean section may have a risk of massive hemorrhage postoperatively as in the present case.

    DOI: 10.4103/GMIT.GMIT_69_18

    PubMed

    researchmap

  • Multiple part umbilical cord entanglement and neonatal outcomes. International journal

    Tasuku Mariya, Yuya Fujibe, Shota Shinkai, Naoko Sugita, Masahiro Suzuki, Toshiaki Endo, Tsuyoshi Saito

    Taiwanese journal of obstetrics & gynecology   57 ( 5 )   672 - 676   2018.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Umbilical cord entanglement is known to be a major cause of fetal hypoxia and to be correlated with several neonatal complications, but almost all of the previous reports were restricted to nuchal cord. In this study, we retrospectively examined the correlation between multiple part cord entanglement and pregnancy outcomes. MATERIALS AND METHODS: A total of 2156 cases were recruited from term deliveries in our hospital from 2008 to 2012. We counted umbilical cord loop numbers not only for nuchal cord but also for trunk and limb cord entanglement. We classified the cases into three groups: no loop, single loop and multiple loops group. We statistically analyzed pregnancy outcomes statistically in the three groups. RESULTS: One thousand, four hundred and fifty-eight cases had no cord entanglement, 594 cases had single loop entanglement and 104 cases had multiple loops entanglement. Values of umbilical artery blood, pH (p = 0.002) and base excess (p < 0.001) showed significantly unfavorable status in entanglement cases, especially in the multiple loops group. A significantly larger percentage of neonates in the multiple loops group needed for oxygen (p < 0.001). CONCLUSION: Multiple umbilical cord entanglement is highly correlated with early neonatal unfavorable status and need for resuscitation.

    DOI: 10.1016/j.tjog.2018.09.001

    PubMed

    researchmap

  • Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues. International journal

    Shinichi Hashimoto, Yuta Tabuchi, Hideaki Yurino, Yoshihiko Hirohashi, Shungo Deshimaru, Takuya Asano, Tasuku Mariya, Kenshiro Oshima, Yuzuru Takamura, Yoshiaki Ukita, Akio Ametani, Naoto Kondo, Norikazu Monma, Tadayuki Takeda, Sadahiko Misu, Toshitugu Okayama, Kazuho Ikeo, Tsuyoshi Saito, Shuich Kaneko, Yutaka Suzuki, Masahira Hattori, Kouji Matsushima, Toshihiko Torigoe

    Scientific reports   7 ( 1 )   14225 - 14225   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Single cell transcriptome analysis of a cancer tissue can provide objective assessment of subtype population or the activation of each of various microenvironment component cells. In this study, we applied our newly developed technique of single cell analysis to the myometrial infiltration side (M-side) and the endometrial side (E-side) of a human endometrioid adenocarcinoma with squamous differentiation tissues. We also analyzed spherogenic cultures derived from the same tissue to identify putative regulators of stemness in vivo. Cancer cells in the E-side were highly malignant compared with those in the M-side. Many cells on the E-side were positive for spheroid-specific tumorigenesis-related markers including SOX2. In addition, there were higher numbers of epithelial-to-mesenchymal transition (EMT) cells in the E-side compared with the M-side. This study identified a site containing cells with high malignant potential such as EMT and cancer stem-like cells in cancer tissues. Finally, we demonstrate that established endometrioid adenocarcinoma subtype classifiers were variably expressed across individual cells within a tumor. Thus, such intratumoral heterogeneity may be related to prognostic implications.

    DOI: 10.1038/s41598-017-14676-3

    PubMed

    researchmap

  • Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27. International journal

    Kazuyo Yasuda, Yoshihiko Hirohashi, Tasuku Mariya, Aiko Murai, Yuta Tabuchi, Takafumi Kuroda, Hiroki Kusumoto, Akari Takaya, Eri Yamamoto, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Yasuaki Tamura, Hiroshi Hirano, Tadashi Hasegawa, Tsuyoshi Saito, Noriyuki Sato, Toshihiko Torigoe

    Oncotarget   8 ( 19 )   31540 - 31553   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Cancer stem-like cells (CSCs)/ cancer-initiating cells (CICs) are defined by their higher tumor-initiating ability, self-renewal capacity and differentiation capacity. CSCs/CICs are resistant to several therapies including chemotherapy and radiotherapy. CSCs/CICs thus are thought to be responsible for recurrence and distant metastasis, and elucidation of the molecular mechanisms of CSCs/CICs are essential to design CSC/CIC-targeting therapy. In this study, we analyzed the molecular aspects of gynecological CSCs/CICs. Gynecological CSCs/CICs were isolated as ALDH1high cell by Aldefluor assay. The gene expression profile of CSCs/CICs revealed that several genes related to stress responses are preferentially expressed in gynecological CSCs/CICs. Among the stress response genes, a small heat shock protein HSP27 has a role in the maintenance of gynecological CSCs/CICs. The upstream transcription factor of HSP27, heat shock factior-1 (HSF1) was activated by phosphorylation at serine 326 residue (pSer326) in CSCs/CICs, and phosphorylation at serine 326 residue is essential for induction of HSP27. Immunohistochemical staining using clinical ovarian cancer samples revealed that higher expressions of HSF1 pSer326 was related to poorer prognosis. These findings indicate that activation of HSF1 at Ser326 residue and transcription of HSP27 is related to the maintenance of gynecological CSCs/CICs.

    DOI: 10.18632/oncotarget.16361

    PubMed

    researchmap

  • Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy. International journal

    Ryota Horibe, Yoshihiko Hirohashi, Takuya Asano, Tasuku Mariya, Takeshi Suzuki, Akari Takaya, Hiroshi Saijo, Yosuke Shionoya, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Kazue Watanabe, Eri Atsuyama, Shingo Toji, Hiroshi Hirano, Tadashi Hasegawa, Hiroki Takahashi, Noriyuki Sato, Toshihiko Torigoe

    PloS one   12 ( 3 )   e0171460   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Lung cancer is one of the most common malignancies with a high rate of mortality. Lung cancer stem-like cells (CSCs)/ cancer-initiating cells (CICs) play major role in resistance to treatments, recurrence and distant metastasis and eradication of CSCs/CICs is crucial to improve recent therapy. Cytotoxic T lymphocytes (CTLs) are major effectors of cancer immunotherapy, and CTLs recognize antigenic peptides derived from antigens that are presented by major histocompatibility complex (MHC) class I molecules. In this study, we analyzed the potency of a cancer-testis (CT) antigen, brother of the regulator of the imprinted site variant subfamily 6 (BORIS sf6), in lung CSC/CIC immunotherapy. BORIS sf6 mRNA was expressed in lung carcinoma cells (9/19), especially in sphere-cultured lung cancer stem-like cells, and in primary lung carcinoma tissues (4/9) by RT-PCR. Immunohistochemical staining using BORIS sf6-specific antibody revealed that high expression of BORIS sf6 is related to poorer prognosis. CTLs could be induced by using a human leukocyte antigen, (HLA)-A2 restricted antigenic peptide (BORIS C34_24(9)), from all of 3 HLA-A2-positive individuals, and CTL clone cells specific for BORIS C34_24(9) peptide could recognize BORIS sf6-positive, HLA-A2-positive lung carcinoma cells. These results indicate that BORIS sf6 is a novel target of lung cancer immunotherapy that might be useful for targeting treatment-resistant lung cancer stem-like cells.

    DOI: 10.1371/journal.pone.0171460

    PubMed

    researchmap

  • Virological and cytological clearance in laser vaporization and conization for cervical intra-epithelial neoplasia grade 3. International journal

    Tasuku Mariya, Akira Nishikawa, Kanae Sogawa, Riri Suzuki, Masae Saito, Akari Kawamata, Ayumi Shimizu, Takehito Nihei, Tomoko Sonoda, Tsuyoshi Saito

    The journal of obstetrics and gynaecology research   42 ( 12 )   1808 - 1813   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    AIM: Cervical intra-epithelial neoplasia (CIN) is the precancerous stage of cervical cancer. Standard treatment for high-grade CIN is conization of the cervix. The risk of preterm birth following conization has been discussed recently. In contrast, laser vaporization is believed not to affect perinatal outcome, but the long-term effectiveness of each surgical procedure is still unclear. The aim of this prospective unmatched-cohort study was therefore to compare virological and cytological clearance and recurrence risk between conization and vaporization for CIN3. METHODS: Subject consisted of CIN3 patients treated at the present hospital between 2007 to 2011 and followed up until December 2014. One hundred and one patients were treated with laser conization, and 137 with vaporization. The surgical procedure was selected on the basis of colposcopy, pathological grade and patient's hope for pregnancy. RESULTS: There were no significant differences in cure rate, human papilloma virus (HPV) clearance rate or recurrence rates between the conization and vaporization groups. Risk ratio of recurrence for each surgical procedure adjusted for age and HPV persistence status were analyzed on Cox proportional hazards modeling. Recurrence risk ratio for patients treated by vaporization was 6.21 (95%CI: 0.65-59.19; P = 0.111) compared with conization and there were no significant differences. No adverse pregnancy outcome was observed in the vaporization group compared with conization. CONCLUSIONS: Laser vaporization is useful for young patients with CIN3 who hope for pregnancy in the future.

    DOI: 10.1111/jog.13113

    PubMed

    researchmap

  • Olfactory Receptor Family 7 Subfamily C Member 1 Is a Novel Marker of Colon Cancer-Initiating Cells and Is a Potent Target of Immunotherapy. International journal

    Rena Morita, Yoshihiko Hirohashi, Toshihiko Torigoe, Satoko Ito-Inoda, Akari Takahashi, Tasuku Mariya, Hiroko Asanuma, Yasuaki Tamura, Tomohide Tsukahara, Takayuki Kanaseki, Terufumi Kubo, Goro Kutomi, Toru Mizuguchi, Takeshi Terui, Kunihiko Ishitani, Satoshi Hashino, Toru Kondo, Nozomi Minagawa, Norihiko Takahashi, Akinobu Taketomi, Satoru Todo, Masahiro Asaka, Noriyuki Sato

    Clinical cancer research : an official journal of the American Association for Cancer Research   22 ( 13 )   3298 - 309   2016.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: Cancer-initiating cells (CICs) are thought to be essential for tumor maintenance, recurrence, and distant metastasis, and they are therefore reasonable targets for cancer therapy. Cancer immunotherapy is a novel approach to target cancer. In this study, we aimed to establish novel CIC-targeting immunotherapy. EXPERIMENTAL DESIGN: Colorectal cancer (CRC) CICs were isolated as side population (SP) cells. The gene expression profile of CRC CICs was analyzed by cDNA microarray and RT-PCR. Protein expression of olfactory receptor family 7 subfamily C member 1 (OR7C1) were analyzed by Western blot and immunohistochemical staining. The functions of OR7C1 were analyzed by gene overexpression and gene knockdown using siRNAs. OR7C1-positive cells were isolated by a flow cytometer and analyzed. CTLs specific for OR7C1 peptide were generated, and the antitumor effect was addressed by mice adoptive transfer model. RESULTS: OR7C1 has essential roles in the maintenance of colon CICs, and the OR7C1-positive population showed higher tumorigenicity than that of the OR7C1-negative population, indicating that OR7C1 is a novel functional marker for colon CIC. Immunohistochemical staining revealed that OR7C1 high expression was correlated with poorer prognosis in CRC patients. OR7C1-derived antigenic peptide-specific CTLs showed specific cytotoxicity for CICs, and an OR7C1-specific CTL clone showed a greater antitumor effect than did a CTL clone targeting all cancer cells in a CTL adoptive transfer mouse model. CONCLUSIONS: OR7C1 is a novel marker for colon CICs and can be a target of potent CIC-targeting immunotherapy. Clin Cancer Res; 22(13); 3298-309. ©2016 AACR.

    DOI: 10.1158/1078-0432.CCR-15-1709

    PubMed

    researchmap

  • Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer. International journal

    Tasuku Mariya, Yoshihiko Hirohashi, Toshihiko Torigoe, Yuta Tabuchi, Takuya Asano, Hiroshi Saijo, Takafumi Kuroda, Kazuyo Yasuda, Masahito Mizuuchi, Tsuyoshi Saito, Noriyuki Sato

    Oncotarget   7 ( 18 )   26806 - 22   2016.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Epithelial ovarian cancer (EOC) is one of the most lethal cancers in females. Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) have been reported to be origin of primary and recurrent cancers and to be resistant to several treatments. In this study, we identified matrix metalloproteinase-10 (MMP10) is expressed in CSCs/CICs of EOC. An immunohistochemical study revealed that a high expression level of MMP10 is a marker for poor prognosis and platinum resistance in multivariate analysis. MMP10 gene overexpression experiments and MMP10 gene knockdown experiments using siRNAs revealed that MMP10 has a role in the maintenance of CSCs/CICs in EOC and resistance to platinum reagent. Furthermore, MMP10 activate canonical Wnt signaling by inhibiting noncanonical Wnt signaling ligand Wnt5a. Therefore, MMP10 is a novel marker for CSCs/CICs in EOC and that targeting MMP10 is a novel promising approach for chemotherapy-resistant CSCs/CICs in EOC.

    DOI: 10.18632/oncotarget.8645

    PubMed

    researchmap

  • Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy. International journal

    Takuya Asano, Yoshihiko Hirohashi, Toshihiko Torigoe, Tasuku Mariya, Ryota Horibe, Takafumi Kuroda, Yuta Tabuchi, Hiroshi Saijo, Kazuyo Yasuda, Masahito Mizuuchi, Akari Takahashi, Hiroko Asanuma, Tadashi Hasegawa, Tsuyoshi Saito, Noriyuki Sato

    Oncotarget   7 ( 10 )   11223 - 37   2016.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Cervical cancer is a major cause of cancer death in females worldwide. Cervical cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) are resistant to conventional radiotherapy and chemotherapy, and CSCs/CICs are thought to be responsible for recurrence. Eradication of CSCs/CICs is thus essential to cure cervical cancer. In this study, we isolated cervical CSCs/CICs by sphere culture, and we identified a cancer testis (CT) antigen, CTCFL/BORIS, that is expressed in cervical CSCs/CICs. BORIS has 23 mRNA isoform variants classified by 6 subfamilies (sfs), and they encode 17 different BORIS peptides. BORIS sf1 and sf4 are expressed in both CSCs/CICs and non-CSCs/CICs, whereas BORIS sf6 is expressed only in CSCs/CICs. Overexpression of BORIS sf6 in cervical cancer cells increased sphere formation and tumor-initiating ability compared with those in control cells, whereas overexpression of BORIS sf1 and BORIS sf4 resulted in only slight increases. Thus, BORIS sf6 is a cervical CSC/CIC-specific subfamily and has a role in the maintenance of cervical CSCs/CICs. BORIS sf6 contains a specific c-terminal domain (C34), and we identified a human leukocyte antigen (HLA)-A2-restricted antigenic peptide, BORIS C34_24(9) encoded by BORIS sf6. A BORIS C34_24(9)-specific cytotoxic T cell (CTL) clone showed cytotoxicity for BORIS sf6-overexpressing cervical cancer cells. Furthermore, the CTL clone significantly suppressed sphere formation of CaSki cells. Taken together, the results indicate that the CT antigen BORIS sf6 is specifically expressed in cervical CSCs/CICs, that BORIS sf6 has a role in the maintenance of CSCs/CICs, and that BORIS C34_24(9) peptide is a promising candidate for cervical CSC/CIC-targeting immunotherapy.

    DOI: 10.18632/oncotarget.7165

    PubMed

    researchmap

  • HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer. International journal

    Yoshihiko Hirohashi, Toshihiko Torigoe, Tasuku Mariya, Vitaly Kochin, Tsuyoshi Saito, Noriyuki Sato

    Oncoimmunology   4 ( 5 )   e1005507   2015.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Cytotoxic T lymphocytes (CTLs) recognize the human leukocyte antigen (HLA) class I and antigenic peptide complex, and they play a crucial role in cancer immunity. Our recent study revealed that HLA class I downregulation is related to poorer prognosis and a low level of intratumoral CTLs is associated with platinum resistance, indicating the significance of immunological surveillance.

    PubMed

    researchmap

  • HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer Reviewed

    Yoshihiko Hirohashi, Toshihiko Torigoe, Tasuku Mariya, Vitaly Kochin, Tsuyoshi Saito, Noriyuki Sato

    ONCOIMMUNOLOGY   4 ( 5 )   2015.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/2162402X.2015.1005507

    Web of Science

    researchmap

  • Prognostic impact of human leukocyte antigen class I expression and association of platinum resistance with immunologic profiles in epithelial ovarian cancer. International journal

    Tasuku Mariya, Yoshihiko Hirohashi, Toshihiko Torigoe, Takuya Asano, Takafumi Kuroda, Kazuyo Yasuda, Masahito Mizuuchi, Tomoko Sonoda, Tsuyoshi Saito, Noriyuki Sato

    Cancer immunology research   2 ( 12 )   1220 - 9   2014.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Epithelial ovarian cancer (EOC) is one of the most deadly carcinomas in females. Immune systems can recognize EOCs; however, a defect of human leukocyte antigen (HLA) class I expression is known to be a major mechanism for escape from immune systems, resulting in poor prognosis. The purpose of this study is to identify novel correlations between immunologic responses and other clinical factors. We investigated the expression of immunologic components in 122 cases of EOCs for which surgical operations were performed between 2001 and 2011. We immunohistochemically stained EOC specimens using an anti-pan HLA class I monoclonal antibody (EMR8-5) and anti-CD3, -CD4, and -CD8 antibodies, and we analyzed correlations between immunologic parameters and clinical factors. In multivariate analysis that used the Cox proportional hazards model, independent prognostic factors for overall survival in advanced EOCs included low expression level of HLA class I [risk ratio (RR), 1.97; 95% confidence interval (CI), 1.01-3.83; P = 0.046] and loss of intraepithelial cytotoxic T lymphocyte (CTL) infiltration (RR, 2.11; 95% CI, 1.06-4.20; P = 0.033). Interestingly, almost all platinum-resistant cases showed a significantly low rate of intraepithelial CTL infiltration in the χ(2) test (positive vs. negative: 9.0% vs. 97.7%; P < 0.001). Results from a logistic regression model revealed that low CTL infiltration rate was an independent factor of platinum resistance in multivariate analysis (OR, 3.77; 95% CI, 1.08-13.12; P = 0.037). Platinum-resistant EOCs show poor immunologic responses. The immune escape system of EOCs may be one of the mechanisms of platinum resistance.

    DOI: 10.1158/2326-6066.CIR-14-0101

    PubMed

    researchmap

  • Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity. International journal

    Kazuyo Yasuda, Toshihiko Torigoe, Tasuku Mariya, Takuya Asano, Takafumi Kuroda, Junichi Matsuzaki, Kanae Ikeda, Makoto Yamauchi, Makoto Emori, Hiroko Asanuma, Tadashi Hasegawa, Tsuyoshi Saito, Yoshihiko Hirohashi, Noriyuki Sato

    Laboratory investigation; a journal of technical methods and pathology   94 ( 12 )   1355 - 69   2014.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) are defined as a small population of cells within cancer that contribute to cancer initiation and progression. Cancer-associated fibroblasts (CAFs) are stromal fibroblasts surrounding tumor cells, and they have important roles in tumor growth and tumor progression. It has been suggested that stromal fibroblasts and CSCs/CICs might mutually cooperate to enhance their growth and tumorigenic capacity. In this study, we investigated the effects of fibroblasts on tumor-initiating capacity and stem-like properties of ovarian CSCs/CICs. CSCs/CICs were isolated from the ovarian carcinoma cell line HTBoA as aldehyde dehydrogenase 1 high (ALDH1(high)) population by the ALDEFLUOR assay. Histological examination of tumor tissues derived from ALDH1(high) cells revealed few fibrous stroma, whereas those derived from fibroblast-mixed ALDH1(high) cells showed abundant fibrous stroma formation. In vivo tumor-initiating capacity and in vitro sphere-forming capacity of ALDH1(high) cells were enhanced in the presence of fibroblasts. Gene expression analysis revealed that fibroblast-mixed ALDH1(high) cells had enhanced expression of fibroblast growth factor 4 (FGF4) as well as stemness-associated genes such as SOX2 and POU5F1. Sphere-forming capacity of ALDH1(high) cells was suppressed by small-interfering RNA (siRNA)-mediated knockdown of FGFR2, the receptor for FGF4 which was expressed preferentially in ALDH1(high) cells. Taken together, the results indicate that interaction of fibroblasts with ovarian CSCs/CICs enhanced tumor-initiating capacity and stem-like properties through autocrine and paracrine FGF4-FGFR2 signaling.

    DOI: 10.1038/labinvest.2014.122

    PubMed

    researchmap

  • BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian cancer. International journal

    Asuka Sugio, Masahiro Iwasaki, Shutaro Habata, Tasuku Mariya, Miwa Suzuki, Hiroyuki Osogami, Masato Tamate, Ryoichi Tanaka, Tsuyoshi Saito

    Gynecologic oncology   134 ( 3 )   615 - 23   2014.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Ovarian cancer is the leading cause of death from gynecologic cancer, reflecting its often late diagnosis and its chemoresistance. We identified a set of microRNAs whose expression is altered upon BAG3 knockdown. Our primary objective was to examine the relationships between BAG3, miR-29b and Mcl-1, an antiapoptotic Bcl-2 family protein, in ovarian cancer cells. METHODS: Ovarian cancer cells were cultured and their responsiveness to paclitaxel was tested. Microarray analysis was performed to identify microRNAs differentially expressed in ES2 BAG3 knockdown ovarian cancer cells and their control cells. Primary ovarian cancer tissues were obtained from 56 patients operated on for ovarian cancer. The patients' clinical and pathological data were obtained from their medical records. RESULTS: BAG3 knockdown increased the chemosensitivity to paclitaxel of ES2 ovarian clear cell carcinoma cells to a greater degree than AMOC2 serous adenocarcinoma cells. qRT-PCR analysis showed that miR-29b expression was significantly upregulated in primary cancer tissue expressing low levels of BAG3, as compared to tissue expressing high levels. Moreover, levels of miR-29b correlated significantly with progression-free survival. Upregulation of miR-29b also reduced levels of Mcl-1 and sensitized ES2 cells to low-dose paclitaxel. CONCLUSIONS: BAG3 knockdown appears to downregulate expression of Mcl-1 through upregulation of miR-29b, thereby increasing the chemosensitivity of ovarian clear cell carcinoma cells. This suggests that BAG3 is a key determinant of the responsiveness of ovarian cancer cells, especially clear cell carcinoma, to paclitaxel and that BAG3 may be a useful therapeutic target for the treatment of ovarian cancer.

    DOI: 10.1016/j.ygyno.2014.06.024

    PubMed

    researchmap

  • Clinical implications of HPV-DNA examination in atypical squamous cells, undetermined significance

    TAMATE Masato, MATSUURA Motoki, TAKENAMI Naoko, MARIYA Tasuku, SATOHISA Seiro, TANAKA Ryoichi, HAYAKAWA Osamu, SAITO Tsuyoshi

    J. Jpn. Soc. Clin. Cytol.   53 ( 5 )   362 - 365   2014

     More details

    Language:Japanese   Publisher:The Japanese Society of Clinical Cytology  

    <b><i>Objective</i></b> : To examine the clinical implications of atypical squamous cells of undetermined significance (ASC-US) in cytology of the uterine cervix.<br><b><i>Study Design</i></b> : We examined the cases of ASC-US diagnosed in our hospital : a total of 12141 women who participated in the screening for cancer of the cervix between January 2010 and December 2011 were included in our study.<br><b><i>Results</i></b> : Of the patients, 1.9% were found to have ASC-US, and 66% of these cases had evidence of infection with high-risk HPV. After one-year follow-up, CIN 1/2 was confirmed in 25/21% of the cases. In 14 of the 19 cases of CIN 1, atypical cytological features could not be detected at the follow-up. We treated 10 cases of CIN 2/3 and followed up 6 cases. Multivariate modeling identified only one factor affecting the risk of CIN, that is high-risk HPV infection.<br><b><i>Conclusion</i></b> : The results of the multivariate analysis identified high-risk HPV infection in cases of ASC-US as an independent risk factor for CIN.

    Other Link: http://search.jamas.or.jp/link/ui/2015067989

    DOI: 10.5795/jjscc.53.362

    researchmap

  • ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis. International journal

    Takafumi Kuroda, Yoshihiko Hirohashi, Toshihiko Torigoe, Kazuyo Yasuda, Akari Takahashi, Hiroko Asanuma, Rena Morita, Tasuku Mariya, Takuya Asano, Masahito Mizuuchi, Tsuyoshi Saito, Noriyuki Sato

    PloS one   8 ( 6 )   e65158   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) are defined as a small population of cancer cells that have high tumorigenicity. Furthermore, CSCs/CICs are resistant to several cancer therapies, and CSCs/CICs are therefore thought to be responsible for cancer recurrence after treatment and distant metastasis. In epithelial ovarian cancer (EOC) cases, disease recurrence after chemotherapy is frequently observed, suggesting ovarian CSCs/CICs are involved. There are four major histological subtypes in EOC, and serous adenocarcinoma and clear cell adenocarcinoma are high-grade malignancies. We therefore analyzed ovarian CSCs/CICs from ovarian carcinoma cell lines (serous adenocarcinoma and clear cell adenocarcinoma) and primary ovarian cancer cells in this study. We isolated ovarian CSCs/CICs as an aldehyde dehydrogenase 1 high (ALDH1(high)) population from 6 EOC cell lines (3 serous adenocarcinomas and 3 clear cell adenocarcinomas) by the ALDEFLUOR assay. ALDH1(high) cells showed greater sphere-forming ability, higher tumorigenicity and greater invasive capability, indicating that ovarian CSCs/CICs are enriched in ALDH1(high) cells. ALDH1(high) cells could also be isolated from 8 of 11 primary ovarian carcinoma samples. Immunohistochemical staining revealed that higher ALDH1 expression levels in ovary cancer cases are related to poorer prognosis in both serous adenocarcinoma cases and clear cell adenocarcinoma cases. Taken together, the results indicate that ALDH1 is a marker for ovarian CSCs/CICs and that the expression level of ALDH1 might be a novel biomarker for prediction of poor prognosis.

    DOI: 10.1371/journal.pone.0065158

    PubMed

    researchmap

  • First case of vaginal radical trachelectomy in a pregnant Japanese woman.

    Nanako Iwami, Shin-ichi Ishioka, Toshiaki Endo, Tsuyoshi Baba, Kunihiko Nagasawa, Madoka Takahashi, Asuka Sugio, Sakura Takada, Tasuku Mariya, Masahiro Mizunuma, Tsuyoshi Saito

    International journal of clinical oncology   16 ( 6 )   737 - 40   2011.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    A diagnosis of cervical cancer during pregnancy poses difficult management and ethical problems. Survival of the patient is the foremost concern, but fetal viability and well-being must also be addressed. Radical trachelectomy (RT) has recently begun to be performed as a possible treatment modality for early stage invasive uterine cervical cancer in pregnant patients who would like to continue their pregnancy. A 32-year-old Japanese woman visited a local hospital for prenatal care, and was diagnosed with a FIGO I B1 adenocarcinoma of the uterine cervix. She had a strong desire to avoid pregnancy termination, so she was admitted to our hospital for fertility-preserving surgery. After extensive counseling, vaginal radical trachelectomy with abdominal pelvic lymphadenectomy was performed in the 16th gestational week. The excised uterine cervix and lymph nodes were pathologically negative for cancer. To maintain her pregnancy, daily vaginal disinfection with povidone iodine, bed rest, and administration of ritodrine and an ulinastatin vaginal suppository were continued until the delivery. At 34 weeks' gestation, an emergency cesarean section was performed because of sudden premature rupture of the membranes. A baby girl was born weighing 2112 g, with Apgar score of 8/9. The mother remains without evidence of recurrence at the time of this report. This is the first case of successful pregnancy and delivery in Japan after vaginal RT.

    DOI: 10.1007/s10147-011-0209-3

    PubMed

    researchmap

▼display all

Books

  • 着床前遺伝学的検査<PGT>の最前線と遺伝カウンセリング

    倉橋 浩樹, 真里谷 奨 他

    メディカルドゥ  2024.1  ( ISBN:9784909508263

     More details

    Total pages:221p   Language:Japanese  

    CiNii Books

    researchmap

MISC

  • LPLとGPIHBP1のバリアントを認めた原発性高カイロミクロン血症の成人発症例

    大久保武志, 隅田健太郎, 國分宣明, 小松茅乃, 宮崎幸子, 真里谷奨, 室田文子, 石川亜貴, 古橋眞人, 櫻井晃洋

    日本内分泌学会雑誌   101 ( 1 )   2025

  • 産婦人科にかかわる医用技術の新たな進歩 II AI技術で行われる診断技術の進化 AIによる病理組織診断支援

    真里谷奨, 梅本美菜, 南部優太, 藤野雄一, 鳥越俊彦, 齋藤豪

    産婦人科の実際   74 ( 2 )   2025

  • マイクロアレイ染色体検査の結果解釈支援ツール「VarporterCNV」の開発と応用

    石川亜貴, 石川亜貴, 石川亜貴, 井戸川雅史, 真里谷奨, 真里谷奨, 重冨浩子, 星野陽子, 櫻井晃洋, 櫻井晃洋

    日本小児遺伝学会学術集会プログラム・抄録集   47th   2025

  • LPLとGPIHBP1のバリアントを認めた原発性高カイロミクロン血症の成人発症例

    大久保武志, 隅田健太郎, 國分宣明, 小松茅乃, 宮崎幸子, 真里谷奨, 室田文子, 石川亜貴, 古橋眞人, 櫻井晃洋

    日本内分泌学会雑誌   101 ( 1 )   2025

  • 多彩な症状を認めた家族性低カルシウム尿性高カルシウム血症3型の家族例

    隅田 健太郎, 宮崎 幸子, 小松 茅乃, 三浦 彩奈, 真里谷 奨, 石川 亜貴, 古橋 眞人, 櫻井 晃洋

    日本内分泌学会雑誌   100 ( 4 )   805 - 805   2024.12

     More details

    Language:Japanese   Publisher:(一社)日本内分泌学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 妊娠初期BVスクリーニング・治療による早産予防は、実臨床では、容易な仕事ではない

    島野 敏司, 山田 俊, 長 和俊, 千石 一雄, 田村 保明, 真里谷 奨, 齋藤 豪

    日本性感染症学会誌   35 ( Suppl. )   118 - 118   2024.11

     More details

    Language:Japanese   Publisher:(一社)日本性感染症学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 【遺伝学的検査Up to Date】遺伝学的検査の応用法を知ろう! 着床前診断を知ろう!

    真里谷 奨, 倉橋 浩樹

    小児科診療   87 ( 11 )   1579 - 1584   2024.11

  • 【産婦人科領域における情報リテラシー-ビッグデータとバイオインフォマティクスの活用】婦人科腫瘍領域におけるAIの活用

    梅本 美菜, 真里谷 奨, 南部 優太, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

    産婦人科の実際   73 ( 8 )   829 - 833   2024.8

     More details

    Language:Japanese   Publisher:金原出版(株)  

    Ichushi

    researchmap

  • 【産婦人科領域における情報リテラシー-ビッグデータとバイオインフォマティクスの活用】婦人科腫瘍領域におけるAIの活用

    梅本 美菜, 真里谷 奨, 南部 優太, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

    産婦人科の実際   73 ( 8 )   829 - 833   2024.8

     More details

    Language:Japanese   Publisher:金原出版(株)  

    Ichushi

    J-GLOBAL

    researchmap

  • 当院における類内膜癌G3症例の細胞診・病理形態学的評価と臨床経過の検討

    幅田 周太朗, 齋藤 晋平, 有元 千紘, 野藤 五沙, 長尾 沙智子, 黒川 晶子, 玉手 雅人, 真里谷 奨, 秋元 太志, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   66回   327 - 327   2024.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    J-GLOBAL

    researchmap

  • Genetic counseling for familial cases of hereditary retinoblastoma

    隅田健太郎, 宮崎幸子, 小松茅乃, 三浦彩奈, 田中佑弥, 真里谷奨, 水上都, 室田文子, 石川亜貴, 櫻井晃洋

    日本遺伝カウンセリング学会誌   45 ( 2 )   95 - 95   2024.7

     More details

  • Examining the impact of the establishment and operation of a gynaecological outpatient clinic specialising in HBOC on clients’ decision-making support

    古来愛香, 真里谷奨, 真里谷奨, 田中佑弥, 小松茅乃, 宮崎幸子, 石川亜貴, 齋藤豪, 櫻井晃洋

    日本遺伝カウンセリング学会誌   45 ( 2 )   120 - 120   2024.7

     More details

  • 当院における類内膜癌G3症例の細胞診・病理形態学的評価と臨床経過の検討

    幅田 周太朗, 齋藤 晋平, 有元 千紘, 野藤 五沙, 長尾 沙智子, 黒川 晶子, 玉手 雅人, 真里谷 奨, 秋元 太志, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   66回   327 - 327   2024.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • Decision-making support for hereditary amyotrophic lateral sclerosis (ALS)

    宮崎幸子, 宮崎幸子, 石川亜貴, 石川亜貴, 田中佑弥, 小松茅乃, 小松茅乃, 隅田健太郎, 水上都, 真里谷奨, 櫻井晃洋, 櫻井晃洋

    日本遺伝カウンセリング学会誌   45 ( 2 )   147 - 147   2024.7

     More details

  • 妊娠中期に多量出血を伴わずに原因不明の産科DICを発症した2例

    齋藤 晋平, 染谷 真行, 真里谷 奨, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   60 ( Suppl.1 )   P336 - P336   2024.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 低置胎盤の分娩管理の変化と,それに伴う周産期転帰の変化について

    染谷 真行, 古来 愛香, 真里谷 奨, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   60 ( Suppl.1 )   P382 - P382   2024.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 妊娠後期に急性腹症と肝酵素上昇を認め,総胆管結石として待機的管理を行った1例

    宮下 夕稀子, 染谷 真行, 真里谷 奨, 馬場 剛, 石岡 伸一, 岡村 直樹, 齋藤 豪

    日本周産期・新生児医学会雑誌   60 ( Suppl.1 )   P395 - P395   2024.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 北海道における、妊娠初期妊婦、全例での細菌性腟症スクリーニング・治療は早産・超早産を有意に減少させた。

    島野 敏司, 山田 俊, 長 和俊, 千石 一雄, 田村 保明, 真里谷 奨, 齋藤 豪

    日本産婦人科感染症学会誌   8 ( 1 )   105 - 105   2024.5

     More details

    Language:Japanese   Publisher:(一社)日本産婦人科感染症学会  

    Ichushi

    researchmap

  • APOBとABCG8のバリアントが複合的に寄与した家族性高コレステロール血症の親子例

    隅田 健太郎, 西川 諒, 宮崎 幸子, 田中 佑弥, 真里谷 奨, 水上 都, 室田 文子, 石川 亜貴, 古橋 眞人, 櫻井 晃洋

    日本内分泌学会雑誌   100 ( 1 )   395 - 395   2024.5

     More details

    Language:Japanese   Publisher:(一社)日本内分泌学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 北海道における、妊娠初期妊婦、全例での細菌性腟症スクリーニング・治療は早産・超早産を有意に減少させた。

    島野 敏司, 山田 俊, 長 和俊, 千石 一雄, 田村 保明, 真里谷 奨, 齋藤 豪

    日本産婦人科感染症学会誌   8 ( 1 )   105 - 105   2024.5

     More details

    Language:Japanese   Publisher:(一社)日本産婦人科感染症学会  

    Ichushi

    J-GLOBAL

    researchmap

  • Embarking on Genetic Counseling Research: Writing Research Papers-Part II-Submitting to the Japanese Journal of Genetic Counseling: The Journey from Research Conceptualization to Conference Presentation and Manuscript Submission-

    河村理恵, 荒川玲子, 市川弥生子, 川崎秀徳, 徳富智明, 真里谷奨, 吉田玲子, 秋山奈々, 金子実基子, 柴田有花, 西山深雪, 福田令, 渡辺基子, 古庄知己

    日本遺伝カウンセリング学会誌   44 ( 4 )   293 - 297   2024.4

     More details

  • 遺伝カウンセリングの研究で論文を書こう!(第2弾) 遺伝カウンセリング学会誌に論文を投稿してみよう 研究立案から学会発表,そして論文化までの道のり

    河村 理恵, 荒川 玲子, 市川 弥生子, 川崎 秀徳, 徳富 智明, 真里谷 奨, 吉田 玲子, 秋山 奈々, 金子 実基子, 柴田 有花, 西山 深雪, 福田 令, 渡辺 基子, 古庄 知己

    日本遺伝カウンセリング学会誌   44 ( 4 )   293 - 297   2024.4

     More details

    Language:Japanese   Publisher:(一社)日本遺伝カウンセリング学会  

    Ichushi

    researchmap

  • 当科における最近10年間のCesarean hysterectomy症例の検討

    齋藤 晋平, 石岡 伸一, 新開 翔太, 真里谷 奨, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 齋藤 豪

    日本産科婦人科学会雑誌   76 ( 臨増 )   S - 592   2024.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 経過観察中に自然軽快した広汎性卵巣浮腫の2症例

    馬場 剛, 遠藤 俊明, 新開 翔太, 真里谷 奨, 染谷 真行, 森下 美幸, 岩崎 雅宏, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   76 ( 臨増 )   S - 383   2024.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • MEN2A型合併悪性褐色細胞腫に131I-MIBG療法を施行した1例

    隅田 健太郎, 菅原 太郎, 三浦 彩奈, 田中 佑弥, 宮崎 幸子, 真里谷 奨, 水上 都, 室田 文子, 石川 亜貴, 古橋 眞人, 櫻井 晃洋

    日本内分泌学会雑誌   99 ( 4 )   740 - 740   2024.1

     More details

    Language:Japanese   Publisher:(一社)日本内分泌学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 胎児巨大心臓腫瘍の出生前後の循環予測に基づいた分娩管理

    佐藤冴子, 染谷真行, 新開翔太, 真里谷奨, 小川万里絵, 森下美幸, 馬場剛, 石岡伸一, 齋藤豪

    日本母体胎児医学会学術集会プログラム・抄録集   46th   2024

  • 妊娠中期に多量出血を伴わずに原因不明の産科DICを発症した2例

    齋藤晋平, 齋藤晋平, 染谷真行, 真里谷奨, 馬場剛, 石岡伸一, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   60 ( Suppl.1 )   2024

  • 完全長total RNA-seqを用いた培養液中胚性cfRNAの解析

    杉本岳, 杉本岳, 真里谷奨, 真里谷奨, 河内谷敏, 倉橋浩樹

    Journal of Mammalian Ova Research   41 ( 1 )   2024

  • 婦人科遺伝性腫瘍診療の実情から考えるゲノム医療の性差における課題

    真里谷奨, 真里谷奨, 田中佑弥, 小松茅乃, ミューラー志乃, ミューラー志乃, 宮崎幸子, 石川亜貴, 井戸川雅史, 齋藤豪, 櫻井晃洋

    日本性差医学・医療学会学術集会プログラム・抄録集   17th   2024

  • 低置胎盤の分娩管理の変化と,それに伴う周産期転帰の変化について

    染谷真行, 古来愛香, 真里谷奨, 馬場剛, 石岡伸一, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   60 ( Suppl.1 )   2024

  • 妊娠後期に急性腹症と肝酵素上昇を認め,総胆管結石として待機的管理を行った1例

    宮下夕稀子, 宮下夕稀子, 染谷真行, 真里谷奨, 馬場剛, 石岡伸一, 岡村直樹, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   60 ( Suppl.1 )   2024

  • ToMMo 54KJPNデータを用いた日本人一般集団における遺伝性腫瘍関連の病的バリアント頻度ならびに病原性解析について

    真里谷奨, 真里谷奨, 井戸川雅史, 田中佑弥, 仲瀬裕志, 時野隆至, 齋藤豪, 櫻井晃洋, 櫻井晃洋

    日本遺伝性腫瘍学会学術集会プログラム・抄録集   30th   2024

  • 胎盤FFPE組織を用いた比較プロテオーム解析による妊娠高血圧症候群のバイオマーカー探索

    高田未咲, 高澤啓, 高澤久美, 染谷真行, 石岡伸一, 真柄和史, 小野佑輔, 及能大輔, 真里谷奨, 杉田真太朗, 長谷川匡, 小山内誠, 齋藤豪

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   56th (CD-ROM)   2024

  • 対照学習とアテンション機構を用いた細胞診断支援におけるExplainable AI構築について

    真里谷奨, 南部優太, 梅本美菜, 石榑康雄, 藤野雄一, 上野太郎, 廣橋良彦, 鳥越俊彦, 齋藤豪

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   56th (CD-ROM)   2024

  • Efficacy of genotype-matched therapy in patients with locally advanced or metastatic solid tumors

    久保智洋, 在原洋平, 中村元, 室田文子, 室田文子, 真里谷奨, 真里谷奨, 村松丈児, 大森銀治, 鈴木慎人, 櫻井晃洋, 高田弘一

    日本臨床腫瘍学会学術集会(CD-ROM)   21st   2024

  • 北海道では、妊娠初期全例での細菌性腟症(BV)スクリーニング・治療により、早産・超早産の有意な減少をみた

    島野 敏司, 山田 俊, 長 和俊, 千石 一雄, 田村 保明, 真里谷 奨, 斎藤 豪

    日本性感染症学会誌   34 ( 2 )   89 - 89   2023.11

     More details

    Language:Japanese   Publisher:(一社)日本性感染症学会  

    Ichushi

    researchmap

  • 【婦人科悪性腫瘍手術-トラブルシューティングとその予防法-】単純外陰切除術

    齋藤 豪, 松浦 基樹, 玉手 雅人, 真里谷 奨

    産婦人科の実際   72 ( 12 )   1397 - 1401   2023.11

     More details

    Language:Japanese   Publisher:金原出版(株)  

    Ichushi

    J-GLOBAL

    researchmap

  • 北海道では、妊娠初期全例での細菌性腟症(BV)スクリーニング・治療により、早産・超早産の有意な減少をみた

    島野 敏司, 山田 俊, 長 和俊, 千石 一雄, 田村 保明, 真里谷 奨, 斎藤 豪

    日本性感染症学会誌   34 ( 2 )   89 - 89   2023.11

     More details

    Language:Japanese   Publisher:(一社)日本性感染症学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 【AIがもたらす婦人科癌医療の新展開】深層学習を利用したHE染色からの子宮内膜癌MMR status判定の可否に関する検討

    梅本 美菜, 真里谷 奨, 永田 舞, 堀米 俊弘, 新開 翔太, 杉田 真太朗, 金関 貴幸, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 長谷川 匡, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   65回   153 - 153   2023.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 当院における婦人科癌に対するがん遺伝子パネル検査の現状と課題

    野藤 五沙, 真里谷 奨, 田中 佑弥, 室田 文子, 寺本 瑞絵, 松浦 基樹, 岩崎 雅宏, 石川 亜貴, 高田 弘一, 櫻井 晃洋, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   65回   288 - 288   2023.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    J-GLOBAL

    researchmap

  • Factors influencing the decision of recurrent miscarriage couples to undergo PGT-SR Examination of genetic counseling required for decision-making support

    久々宇千恵, 石川亜貴, 石川亜貴, 真里谷奨, 真里谷奨, 馬場剛, 遠藤俊明, 櫻井晃洋, 櫻井晃洋

    日本遺伝カウンセリング学会誌   44 ( 2 )   155 - 155   2023.6

     More details

  • The Current Status and Issues of Tele-Genetic Counseling at Department of Clinical Genetic, Sapporo Medical University Hospital

    田中佑弥, 石川亜貴, 石川亜貴, 三浦彩奈, 隅田健太郎, 真里谷奨, 水上都, 室田文子, 宮崎幸子, 櫻井晃洋, 櫻井晃洋

    日本遺伝カウンセリング学会誌   44 ( 2 )   162 - 162   2023.6

     More details

  • Medical management of unaffected BRCA1/2 pathogenic variant carriers in our hospital

    佐々木西里奈, 真里谷奨, ミューラー志乃, 桑原小百合, 前田豪樹, 山本貢, 富岡伸元, 横内浩, 櫻井晃洋, 渡邊健一

    日本遺伝カウンセリング学会誌   44 ( 2 )   83 - 83   2023.6

     More details

  • Expectations for Perinatal Telemedicine Information Sharing Using IoT Fetal Heart Rate Labor Monitor

    黒田敬史, 真里谷奨, 染谷真行, 堀清貴, 川畑龍暉, 川畑聖羅, 長澤邦彦, 谷垣学, 石岡伸一, 齋藤豪

    日本医療情報学会春季学術大会プログラム・抄録集   27回   191 - 192   2023.6

     More details

  • 巨大腺筋症に対する開腹子宮頸管縫縮術を施行し,救命可能週数まで妊娠継続できた一絨毛膜二羊膜双胎の1例

    常松 梨紗, 石岡 伸一, 馬場 剛, 真里谷 奨, 染谷 真行, 新開 翔太, 齋藤 豪

    日本周産期・新生児医学会雑誌   59 ( Suppl.1 )   P322 - P322   2023.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 深層学習によるHE染色データを用いた子宮内膜癌プロファイル判定の適否に関する検討

    梅本 美菜, 真里谷 奨, 永田 舞, 堀米 俊弘, 新開 翔太, 杉田 真太朗, 金関 貴幸, 松浦 基樹, 岩崎 雅宏, 廣橋 良彦, 長谷川 匡, 鳥越 俊彦, 齋藤 豪, 藤野 雄一

    日本医療情報学会春季学術大会プログラム・抄録集   27回   122 - 123   2023.6

     More details

    Language:Japanese   Publisher:(一社)日本医療情報学会  

    Ichushi

    researchmap

  • A case of malignant pheochromocytoma with multiple endocrine neoplasia type 2A diagnosed in the 30s

    隅田健太郎, 宮崎幸子, 三浦彩奈, 田中佑弥, 真里谷奨, 水上都, 室田文子, 石川亜貴, 櫻井晃洋

    日本遺伝カウンセリング学会誌   44 ( 2 )   124 - 124   2023.6

     More details

  • Examination about provision of appropriate information in genetic counseling about PGT-SR for carriers of balanced chromosome translocations

    葛西彩乃, 真里谷奨, 真里谷奨, 石川亜貴, 馬場剛, 遠藤俊明, 尾崎守, 櫻井晃洋

    日本遺伝カウンセリング学会誌   44 ( 2 )   133 - 133   2023.6

     More details

  • Aggressive angiomyxoma(AAM)合併妊娠の一例

    古来 愛香, 石岡 伸一, 新開 翔太, 常松 梨紗, 真里谷 奨, 染谷 真行, 松浦 基樹, 馬場 剛, 齋藤 剛

    日本周産期・新生児医学会雑誌   59 ( Suppl.1 )   P438 - P438   2023.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 中心核ミオパチーの児出産を契機に発見された1型リアノジン受容体(RYR1)遺伝子の病的バリアントを有する妊婦の一例

    古来 愛香, 石岡 伸一, 真里谷 奨, 藤部 佑哉, 坂井 拓朗, 染谷 真行, 齊藤 豪

    日本周産期・新生児医学会雑誌   59 ( 1 )   111 - 115   2023.5

  • 中心核ミオパチーの児出産を契機に発見された1型リアノジン受容体(RYR1)遺伝子のバリアントを有する妊婦の一例

    古来 愛香, 石岡 伸一, 新開 翔太, 真里谷 奨, 常松 梨紗, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 齋藤 豪

    日本産科婦人科学会雑誌   75 ( 臨増 )   S - 459   2023.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    researchmap

  • Cell-free RNA発現プロファイルを根拠とした新規無侵襲着床前胚染色体異数性検査アルゴリズムの構築について

    真里谷 奨, 齋藤 豪, 倉橋 浩樹

    日本産科婦人科学会雑誌   75 ( 臨増 )   S - 430   2023.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    researchmap

  • 深層学習を用いたHE染色からの子宮内膜癌分子生物学的プロファイル推定の適否に関する検討

    梅本 美菜, 真里谷 奨, 新開 翔太, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

    日本産科婦人科学会雑誌   75 ( 臨増 )   S - 260   2023.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    researchmap

  • Cell-free RNA発現プロファイルを根拠とした新規無侵襲着床前胚染色体異数性検査アルゴリズムの構築について

    真里谷 奨, 齋藤 豪, 倉橋 浩樹

    日本産科婦人科学会雑誌   75 ( 臨増 )   S - 430   2023.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 中心核ミオパチーの児出産を契機に発見された1型リアノジン受容体(RYR1)遺伝子のバリアントを有する妊婦の一例

    古来 愛香, 石岡 伸一, 新開 翔太, 真里谷 奨, 常松 梨紗, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 齋藤 豪

    日本産科婦人科学会雑誌   75 ( 臨増 )   S - 459   2023.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • IoT胎児心拍陣痛モニターによる切迫早産患者の在宅モニタリングと事後アンケートの検討

    黒田 敬史, 堀 清貴, 川畑 聖羅, 川畑 龍暉, 小林 寛治, 真里谷 奨, 染谷 真行, 谷垣 学, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   75 ( 臨増 )   S - 486   2023.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    researchmap

  • IoT胎児心拍陣痛モニターによる切迫早産患者の在宅モニタリングと事後アンケートの検討

    黒田 敬史, 堀 清貴, 川畑 聖羅, 川畑 龍暉, 小林 寛治, 真里谷 奨, 染谷 真行, 谷垣 学, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   75 ( 臨増 )   S - 486   2023.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • がんゲノムプロファイリング検査における二次的所見の取り扱いについて

    西川香奈子, 高田弘一, 真里谷奨, 室田文子, 宮崎幸子, 宮崎幸子, 三浦彩奈, 田中佑弥, 櫻井晃洋, 櫻井晃洋

    日本遺伝性腫瘍学会学術集会プログラム・抄録集   29th   2023

  • 遺伝専門職による継続的なフォローアップの重要性を再認識させられた家族性大腸ポリポーシス(FAP)の一例

    ミューラー志乃, 真里谷奨, 真里谷奨, 真里谷奨, 平川昌宏, 佐々木西里奈, 箕浦祐子, 皆川のぞみ, 見延進一郎, 横内浩, 横内浩, 櫻井晃洋, 櫻井晃洋

    日本遺伝性腫瘍学会学術集会プログラム・抄録集   29th   2023

  • AI-CAD研究が示す婦人科細胞・病理診断へのインパクトと展望

    真里谷奨, 梅本美菜, 南部優太, 永田舞, 堀米俊弘, 上野太郎, 金関貴幸, 杉田真太朗, 新開翔太, 松浦基樹, 岩崎雅宏, 廣橋良彦, 長谷川匡, 鳥越敏彦, 藤野雄一, 齋藤豪

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   55th   2023

  • 7年の経過で多発性骨転移を来したMEN2A型合併両側褐色細胞腫の一例

    隅田健太郎, 三浦彩奈, 宮崎幸子, 真里谷奨, 水上都, 室田文子, 石川亜貴, 櫻井晃洋

    日本遺伝性腫瘍学会学術集会プログラム・抄録集   29th   2023

  • 血縁者内の遺伝学的検査におけるバリアントの共有性についての検討

    宮崎幸子, 宮崎幸子, 田中佑弥, 三浦彩奈, 隅田健太郎, 水上都, 真里谷奨, 室田文子, 石川亜貴, 石川亜貴, 櫻井晃洋, 櫻井晃洋

    日本遺伝性腫瘍学会学術集会プログラム・抄録集   29th   2023

  • 当院における婦人科癌に対するがん遺伝子パネル検査の現状と遺伝子診療部門としての課題

    真里谷奨, 真里谷奨, 野藤五沙, 三浦彩奈, 室田文子, 寺本瑞絵, 松浦基樹, 岩崎雅宏, 石川亜貴, 高田弘一, 齋藤豪, 櫻井晃洋

    日本遺伝性腫瘍学会学術集会プログラム・抄録集   29th   2023

  • Ryanodine receptor 1 (RYR1) gene variant discovered after the birth of a child with centronuclear myopathy: A case report

    古来愛香, 石岡伸一, 真里谷奨, 藤部佑哉, 坂井拓朗, 染谷真行, 齊藤豪

    日本周産期・新生児医学会雑誌(Web)   59 ( 1 )   2023

  • 巨大腺筋症に対する開腹子宮頸管縫縮術を施行し,救命可能週数まで妊娠継続できた一絨毛膜二羊膜双胎の1例

    常松梨紗, 石岡伸一, 馬場剛, 真里谷奨, 染谷真行, 新開翔太, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   59 ( Suppl.1 )   2023

  • Aggressive angiomyxoma(AAM)合併妊娠の一例

    古来愛香, 石岡伸一, 新開翔太, 常松梨紗, 真里谷奨, 染谷真行, 松浦基樹, 馬場剛, 齋藤剛

    日本周産期・新生児医学会雑誌(Web)   59 ( Suppl.1 )   2023

  • ロングリードシーケンスにより染色体内挿入を伴う複雑な染色体再構成が確認されたMECP2重複症候群の一例

    真里谷奨, 真里谷奨, 真里谷奨, 河村理恵, 宮井俊輔, 稲垣秀人, 庵前美智子, 中岡義晴, 倉橋浩樹

    日本小児遺伝学会学術集会プログラム・抄録集   45th   2023

  • Ryanodine receptor 1(<i>RYR1</i>)gene variant discovered after the birth of a child with centronuclear myopathy: A case report

    Korai Aika, Ishioka Shinichi, Mariya Tasuku, Fujibe Yuya, Sakai Takuro, Someya Masayuki, Saito Tsuyoshi

    Journal of Japan Society of Perinatal and Neonatal Medicine   59 ( 1 )   111 - 115   2023

     More details

    Language:Japanese   Publisher:Japan Society of Perinatal and Neonatal Medicine  

    DOI: 10.34456/jjspnm.59.1_111

    CiNii Research

    Ichushi

    researchmap

  • 細胞診におけるAIの活用 子宮頸部細胞診におけるAIの活用

    新開 翔太, 真里谷 奨, 梅本 美菜, 南部 優太, 永田 舞, 淺沼 広子, 上野 太郎, 廣橋 良彦, 鳥越 俊彦, 佐藤 生馬, 藤野 雄一, 齋藤 豪

    日本臨床細胞学会雑誌   61 ( Suppl.2 )   447 - 447   2022.10

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • Label Smoothingを併用した2段階CNNによる子宮頸部細胞診断支援アルゴリズムについて

    梅本 美菜, 真里谷 奨, 南部 優太, 新開 翔太, 永田 舞, 淺沼 広子, 廣橋 良彦, 鳥越 俊彦, 佐藤 生真, 藤野 雄一, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   64回   189 - 189   2022.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 当科における分娩時hysterectomy症例の検討

    石岡 伸一, 染谷 真行, 柏木 葉月, 藤部 佑哉, 真里谷 奨, 馬場 剛, 斎藤 豪

    日本周産期・新生児医学会雑誌   58 ( Suppl.1 )   297 - 297   2022.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 異常浸潤性胎盤における胎盤絨毛の血管構造の病理組織学的解析

    柏木 葉月, 真里谷 奨, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   58 ( Suppl.1 )   363 - 363   2022.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 児の緩和的対応を前提とした新生児予後不良な妊娠における,適切な医療体制について

    染谷 真行, 古来 愛香, 真里谷 奨, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   58 ( Suppl.1 )   310 - 310   2022.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 妊娠中の脳腫瘍に対し,周期的なテモゾロミド投与を行った一例

    齋藤 晋平, 古来 愛香, 真里谷 奨, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   58 ( Suppl.1 )   323 - 323   2022.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 胎児超音波にて屈曲肢骨異形成症を疑い,胎盤絨毛の遺伝子検査で診断確定した一例

    小川 万梨絵, 寺本 瑞絵, 染谷 真行, 石堂 茉泉, 新開 翔太, 真里谷 奨, 池田 桂子, 森下 美幸, 久野 芳佳, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   74 ( 臨増 )   S - 374   2022.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • CD138免疫染色と子宮内microbiotaのcombined testに子宮内pH測定を加えた慢性子宮内膜炎の病態整理

    遠藤 俊明, 池田 詩子, 逸見 博文, 本間 寛之, 木谷 保, 真里谷 奨, 久野 芳佳, 馬場 剛, 山田 秀人, 東口 篤司, 藤井 美穂, 齋藤 豪

    日本産科婦人科学会雑誌   74 ( 臨増 )   S - 359   2022.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 全ゲノムシーケンスとFISH解析により腕内逆位関連病的変異が同定されたメープルシロップ尿症の一例

    横井克幸, 横井克幸, 中島葉子, 須藤湧太, 真里谷奨, 河村理恵, 堤真紀子, 稲垣秀人, 吉川哲史, 伊藤哲哉, 倉橋浩樹

    日本人類遺伝学会大会(CD-ROM)   67th   2022

  • An AI-Based Diagnostic Supporting Method for Cervical Adenocarcinoma Cytology using Two-step Detection/Classification

    永田舞, 梅本美菜, 佐藤生馬, 新開翔太, 真里谷奨, 堀米俊弘, 藤野雄一

    LIFE講演概要集(CD-ROM)   2022   2022

  • 当科における分娩時hysterectomy症例の検討

    石岡伸一, 染谷真行, 柏木葉月, 藤部佑哉, 真里谷奨, 馬場剛, 斎藤豪

    日本周産期・新生児医学会雑誌(Web)   58 ( Suppl.1 )   2022

  • 異常浸潤性胎盤における胎盤絨毛の血管構造の病理組織学的解析

    柏木葉月, 真里谷奨, 石岡伸一, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   58 ( Suppl.1 )   2022

  • 児の緩和的対応を前提とした新生児予後不良な妊娠における,適切な医療体制について

    染谷真行, 古来愛香, 真里谷奨, 馬場剛, 石岡伸一, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   58 ( Suppl.1 )   2022

  • 妊娠中の脳腫瘍に対し,周期的なテモゾロミド投与を行った一例

    齋藤晋平, 齋藤晋平, 古来愛香, 真里谷奨, 馬場剛, 石岡伸一, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   58 ( Suppl.1 )   2022

  • 複雑なX染色体重複領域を伴う症例におけるターゲットロングリードシーケンスを用いた構造解析およびPGT-Mセットアップについて

    真里谷奨, 真里谷奨, 真里谷奨, 七里由衣, 杉本岳, 河村理恵, 宮井俊輔, 稲垣秀人, 杉原英志, 池田桂子, 馬場剛, 石川亜貴, 庵前美智子, 中村義晴, 齋藤豪, 櫻井晃洋, 倉橋浩樹

    日本人類遺伝学会大会(CD-ROM)   67th   2022

  • 子宮頸部感染より考える妊婦子宮がん検診におけるブラシ使用の産科予後への影響

    石岡伸一, 真里谷奨, 玉手雅人, 幅田周太朗, 松浦基樹, 岩崎雅宏, 斎藤豪

    日本婦人科がん検診学会総会・学術集会プログラム・抄録集   31st   2022

  • 子宮頸部扁平上皮病変進展様式に適合した学習アルゴリズムの診断支援システムへの適用

    真里谷奨, 南部優太, 新開翔太, 梅本美菜, 永田舞, 佐藤生馬, 上野太郎, 淺沼広子, 廣橋良彦, 鳥越俊彦, 藤野雄一, 齋藤豪

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   54th   2022

  • Learning of Squamous Cell Image Classification Model Using Preference Learning to Assist Cervical Cytology

    南部優太, 真里谷奨, 新開翔太, 梅本美菜, 淺沼広子, 廣橋良彦, 齋藤豪, 鳥越俊彦, 佐藤生馬, 藤野雄一

    電子情報通信学会技術研究報告(Web)   122 ( 188(MI2022 49-62) )   2022

  • 子宮頸部細胞診におけるAIの活用

    新開翔太, 真里谷奨, 梅本美菜, 南部優太, 永田舞, 淺沼広子, 上野太郎, 廣橋良彦, 鳥越俊彦, 佐藤生馬, 藤野雄一, 齋藤豪

    日本臨床細胞学会雑誌(Web)   61   2022

  • マイクロバイオーム最前線-ヒト常在菌叢と各種疾患との関連- 腟内および子宮内細菌叢Dysbiosisへの真なるアプローチとは?

    真里谷 奨, 島野 敏司, 遠藤 俊明, 和田 真一郎, 山田 秀人, 藤井 美穂, 水無瀬 昂, 桜庭 喜行, 鳥越 俊彦, 齋藤 豪

    日本臨床微生物学会雑誌   32 ( Suppl.1 )   164 - 164   2021.12

     More details

    Language:Japanese   Publisher:(一社)日本臨床微生物学会  

    Ichushi

    researchmap

  • マイクロバイオーム最前線-ヒト常在菌叢と各種疾患との関連- 腟内および子宮内細菌叢Dysbiosisへの真なるアプローチとは?

    真里谷 奨, 島野 敏司, 遠藤 俊明, 和田 真一郎, 山田 秀人, 藤井 美穂, 水無瀬 昂, 桜庭 喜行, 鳥越 俊彦, 齋藤 豪

    日本臨床微生物学会雑誌   32 ( Suppl.1 )   164 - 164   2021.12

     More details

    Language:Japanese   Publisher:(一社)日本臨床微生物学会  

    Ichushi

    researchmap

  • 妊娠女性の頸部細胞診 妊娠中施行radical trachelectomy症例における妊娠中細胞診の変化

    石岡 伸一, 新開 翔太, 真里谷 奨, 玉手 雅人, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

    日本臨床細胞学会雑誌   60 ( Suppl.2 )   458 - 458   2021.10

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • 周術期血小板輸血にて腹腔鏡下子宮全摘出術を施行し得た血小板無力症の1例

    阿部 秀悦, 伊野 善彦, 西尾 空, 北 香, 真里谷 奨, 柿木 康孝, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   37 ( Suppl.I )   273 - 273   2021.9

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 多発性粘膜下筋腫に対して子宮動脈塞栓術後に腹腔鏡下子宮筋腫摘出術を施行した一例

    野藤 五沙, 和田 渚, 安宅 真名美, 野呂 薫, 柏木 葉月, 真里谷 奨, 幅田 周太朗, 池田 圭子, 岩崎 雅宏, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   37 ( Suppl.I )   264 - 264   2021.9

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 婦人科腫瘍を疑われた乳癌子宮転移の一例

    中野 遥香, 野藤 五沙, 和田 渚, 西森 貢隆, 安宅 真名美, 野呂 薫, 柏木 葉月, 真里谷 奨, 幅田 周太朗, 池田 桂子, 岩崎 雅弘, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   68回   61 - 61   2021.8

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 肉腫成分過剰増殖を伴う子宮腺肉腫の一例

    和田 渚, 幅田 周太朗, 安宅 真名美, 野呂 薫, 柏木 葉月, 野藤 五沙, 玉手 雅人, 真里谷 奨, 池田 桂子, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   68回   60 - 60   2021.8

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 子宮体癌と大腸癌におけるミスマッチ修復タンパク欠損と免疫逃避機構の差異に関する検討

    真里谷 奨, 廣橋 良彦, 久保 輝文, 岩崎 雅宏, 鳥越 俊彦, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   214 - 214   2021.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 婦人科腫瘍を疑われた乳癌子宮転移の一例

    野藤 五沙, 西森 貢隆, 安宅 真名美, 柏木 葉月, 真里谷 奨, 池田 圭子, 岩崎 雅宏, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   288 - 288   2021.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 子宮温存している若年発症子宮体部腺肉腫の2例

    寺田 倫子, 松浦 基樹, 野藤 五沙, 西村 庸子, 真里谷 奨, 玉手 雅人, 岩崎 雅宏, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   292 - 292   2021.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • 婦人科腫瘍を疑われた乳癌子宮転移の一例

    野藤 五沙, 西森 貢隆, 安宅 真名美, 柏木 葉月, 真里谷 奨, 池田 圭子, 岩崎 雅宏, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   288 - 288   2021.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • 子宮体癌と大腸癌におけるミスマッチ修復タンパク欠損と免疫逃避機構の差異に関する検討

    真里谷 奨, 廣橋 良彦, 久保 輝文, 岩崎 雅宏, 鳥越 俊彦, 齋藤 豪

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   63回   214 - 214   2021.7

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • 妊娠糖尿病患者における妊娠中の適切な体重増加の検討

    藤部 佑哉, 嶋田 浩志, 真里谷 奨, 倉 ありさ, 西森 貢隆, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   57 ( Suppl. )   P221 - P221   2021.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 当科におけるModified B-Lynch縫合施行21症例の検討

    安宅 真名美, 石岡 伸一, 新開 翔太, 真里谷 奨, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 齋藤 豪

    産婦人科手術   ( 32 )   146 - 146   2021.6

     More details

    Language:Japanese   Publisher:(株)メジカルビュー社  

    Ichushi

    J-GLOBAL

    researchmap

  • 腟式広汎子宮頸部摘出術後妊娠症例におけるFFPE胎盤検体を用いたメタゲノム解析の試み

    真里谷 奨, 石岡 伸一, 長井 陽子, 藤部 佑哉, 新開 翔太, 染谷 真行, 馬場 剛, 齋藤 豪

    日本周産期・新生児医学会雑誌   57 ( Suppl. )   P237 - P237   2021.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 子宮粘膜下に発達した嚢胞性腺筋症に対し腹腔鏡下核出術を施行した1例

    小川 栞, 真里谷 奨, 新開 翔太, 久野 芳佳, 森下 美幸, 馬場 剛, 齋藤 豪

    産婦人科手術   ( 32 )   142 - 142   2021.6

     More details

    Language:Japanese   Publisher:(株)メジカルビュー社  

    Ichushi

    J-GLOBAL

    researchmap

  • 異常浸潤性胎盤におけるPSGファミリーの新規バイオマーカーとしての可能性

    柏木 葉月, 真里谷 奨, 新開 翔太, 染谷 真行, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   57 ( Suppl. )   P202 - P202   2021.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 妊婦検診時の子宮頸癌検診のメリットと問題点-特に採取器具の違いによる精度と副障害の現況 妊婦に対するCervexブラシを用いた子宮頸部細胞診は、腟内感染の原因となるか?

    石岡 伸一, 金 美善, 真里谷 奨, 藤部 佑哉, 齋藤 豪

    日本臨床細胞学会雑誌   60 ( Suppl.1 )   166 - 166   2021.5

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • 体腔液セルブロックによる免疫染色の検討

    玉手 雅人, 松浦 基樹, 西村 庸子, 新開 翔太, 真里谷 奨, 寺田 倫子, 岩崎 雅宏, 石岡 伸一, 杉田 真太朗, 齋藤 豪

    日本臨床細胞学会雑誌   60 ( Suppl.1 )   189 - 189   2021.5

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • AIを活用した細胞・画像診断の進歩と展望 深層学習手法YOLOを用いた子宮頸部細胞診診断支援システムの検討

    新開 翔太, 真里谷 奨, 梅本 美菜, 南部 優太, 淺沼 広子, 廣橋 良彦, 鳥越 俊彦, 藤野 雄一, 齋藤 豪

    日本臨床細胞学会雑誌   60 ( Suppl.1 )   126 - 126   2021.5

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • 流産手術後に長期間の反復菌血症を呈しミュンヒハウゼン症候群が疑われた1例

    真里谷 奨, 長井 陽子, 藤谷 好弘, 黒沼 幸治, 高橋 聡

    感染症学雑誌   95 ( 臨増 )   288 - 288   2021.4

     More details

    Language:Japanese   Publisher:(一社)日本感染症学会  

    Ichushi

    researchmap

  • Tocolysisの有用性よりみた出生体重1,000g未満母体症例に関する検討

    山下 真祐子, 石岡 伸一, 真里谷 奨, 新開 翔太, 染谷 真行, 森下 美幸, 馬場 剛, 齋藤 豪

    周産期医学   51 ( 4 )   675 - 680   2021.4

     More details

    Language:Japanese   Publisher:(株)東京医学社  

    Ichushi

    J-GLOBAL

    researchmap

  • 高次施設における帝王切開率抑制の試み

    染谷 真行, 新開 翔太, 真里谷 奨, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 367   2021.3

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 高次施設における帝王切開率抑制の試み

    染谷 真行, 新開 翔太, 真里谷 奨, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 367   2021.3

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    researchmap

  • PSGファミリーの異常浸潤性胎盤診断バイオマーカーとしての可能性

    柏木 葉月, 真里谷 奨, 新開 翔太, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 611   2021.3

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • PSGファミリーの異常浸潤性胎盤診断バイオマーカーとしての可能性

    柏木 葉月, 真里谷 奨, 新開 翔太, 染谷 真行, 小川 万梨絵, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   73 ( 臨増 )   S - 611   2021.3

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    researchmap

  • 早産期の誘発分娩により帝王切開を回避し得たタナトフォリック骨異形成症の1例

    佐藤 由梨, 染谷 真行, 長尾 沙智子, 新開 翔太, 真里谷 奨, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    北海道産科婦人科学会会誌   65 ( 1 )   85 - 85   2021.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • ERα発現および非発現子宮体癌細胞株に於けるBAG3発現および増殖能との関連

    阿部 秀悦, 岩崎 雅宏, 幅田 周太朗, 真里谷 奨, 小川 万梨絵, 郷久 晴朗, 齋藤 豪

    日本婦人科腫瘍学会雑誌   39 ( 1 )   285 - 285   2021.1

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • 骨盤解剖学をCadaver Surgery Trainingで理解する混合研究の試み

    玉手 雅人, 松浦 基樹, 阿部 秀悦, 西村 庸子, 常松 梨沙, 寺田 倫子, 真里谷 奨, 岩崎 雅宏, 金尾 祐之, 齋藤 豪

    日本婦人科腫瘍学会雑誌   39 ( 1 )   311 - 311   2021.1

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    J-GLOBAL

    researchmap

  • Deep Learning(YOLOv3)を用いたリアルタイム婦人科細胞診断支援システム設計の試み

    真里谷 奨, 新開 翔太, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 南部 優太, 藤野 雄一, 淺沼 広子, 廣橋 良彦, 鳥越 俊彦, 齋藤 豪

    日本婦人科腫瘍学会雑誌   39 ( 1 )   278 - 278   2021.1

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    J-GLOBAL

    researchmap

  • Adaptive sampling法を用いたNanoporeシーケンサーによる小型過剰マーカー染色体の構造決定

    真里谷奨, 真里谷奨, 加藤武馬, 宮井俊輔, 河村理恵, 堤真紀子, 稲垣秀人, 杉原英司, 貝淵弘三, 水野誠司, 倉橋浩樹

    日本人類遺伝学会大会(CD-ROM)   66th   2021

  • 体腔液セルブロックによる免疫染色の検討

    玉手雅人, 松浦基樹, 西村庸子, 新開翔太, 真里谷奨, 寺田倫子, 岩崎雅宏, 石岡伸一, 杉田真太朗, 齋藤豪

    日本臨床細胞学会雑誌(Web)   60   2021

  • 深層学習手法YOLOを用いた子宮頚部細胞診診断支援システムの検討

    新開翔太, 真里谷奨, 真里谷奨, 梅本美菜, 南部優太, 淺沼広子, 廣橋良彦, 鳥越俊彦, 藤野雄一, 齋藤豪

    日本臨床細胞学会雑誌(Web)   60   2021

  • 妊婦に対するCervexブラシを用いた子宮頸部細胞診は,腟内感染の原因となるか?

    石岡伸一, 金美善, 真里谷奨, 藤部佑哉, 齋藤豪

    日本臨床細胞学会雑誌(Web)   60   2021

  • 異常浸潤性胎盤におけるPSGファミリーの新規バイオマーカーとしての可能性

    柏木葉月, 真里谷奨, 真里谷奨, 新開翔太, 染谷真行, 馬場剛, 石岡伸一, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   57 ( Suppl )   2021

  • 妊娠糖尿病患者における妊娠中の適切な体重増加の検討

    藤部佑哉, 嶋田浩志, 真里谷奨, 倉ありさ, 西森貢隆, 石岡伸一, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   57 ( Suppl )   2021

  • 腟式広汎子宮頸部摘出術後妊娠症例におけるFFPE胎盤検体を用いたメタゲノム解析の試み

    真里谷奨, 石岡伸一, 長井陽子, 藤部佑哉, 新開翔太, 染谷真行, 馬場剛, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   57 ( Suppl )   2021

  • 流産手術後に長期間の反復菌血症を呈しミュンヒハウゼン症候群が疑われた1例

    真里谷奨, 長井陽子, 藤谷好弘, 黒沼幸治, 高橋聡

    日本化学療法学会雑誌   69 ( Supplement-A )   2021

  • Breakpoints of three-way translocations enrich in specific chromatin context

    杉本岳, 杉本岳, 加藤武馬, 真里谷奨, 真里谷奨, 倉橋浩樹

    日本人類遺伝学会大会(CD-ROM)   66th   2021

  • 妊娠中施行radical trachelectomy症例における妊娠中細胞診の変化

    石岡伸一, 新開翔太, 真里谷奨, 玉手雅人, 幅田周太朗, 松浦基樹, 岩崎雅宏, 齋藤豪

    日本臨床細胞学会雑誌(Web)   60   2021

  • MSUD with paracentric inversion-associated BCKDHA gene dysfunction identified by whole genome sequencing

    真里谷奨, 真里谷奨, 横井克幸, 中島葉子, 伊藤哲哉, 堤真紀子, 倉橋浩樹

    日本小児遺伝学会学術集会プログラム・抄録集   44th (CD-ROM)   2021

  • FFPE胎盤検体を用いた16S rRNA次世代シークエンス解析による後方視的周産期侵襲性感染精査手法の提案

    真里谷奨, 佐藤豊孝, 藤部佑哉, 石堂茉泉, 嶋田浩志, 久保輝文, 長井陽子, 芦川享大, 桜庭喜行, 石岡伸一, 横田伸一, 齋藤豪

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   53rd   2021

  • YOLOv3を用いた子宮頸部細胞診画像クラスタリング手法の提案

    南部 優太, 真里谷 奨, 新開 翔太, 淺沼 広子, 廣橋 良彦, 齋藤 豪, 鳥越 俊彦, 佐藤 生馬, 藤野 雄一

    医療情報学連合大会論文集   40回   482 - 486   2020.11

     More details

    Language:Japanese   Publisher:(一社)日本医療情報学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 腹腔鏡下子宮筋腫核出術後に発生したparasitic myomaの1例

    岩崎 雅宏, 真里谷 奨, 阿部 秀悦, 松浦 基樹, 玉手 雅人, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 196]   2020.11

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    researchmap

  • 深層学習を用いた子宮頸部細胞診人工知能診断支援システムの有用性について

    真里谷 奨, 南部 優太, 淺沼 広子, 廣橋 良彦, 岩崎 雅宏, 藤野 雄一, 鳥越 俊彦, 齋藤 豪

    日本癌学会総会記事   79回   OJ15 - 7   2020.10

     More details

    Language:English   Publisher:(一社)日本癌学会  

    Ichushi

    researchmap

  • 当院で出生した先天性疾患児の出生前診断状況および遺伝学的対応に関する検討

    真里谷 奨, 斉藤 公仁, 水柿 祐子, 藤部 佑哉, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 水上 都, 石川 亜貴, 石岡 伸一, 櫻井 晃洋, 齋藤 豪

    北海道産科婦人科学会会誌   64 ( 1 )   108 - 108   2020.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • Prune Belly Syndromeの女児が出生後に総排泄腔遺残も疑われた1例

    藤部 佑哉, 真里谷 奨, 蛯谷 由真, 水柿 祐子, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 石岡 伸一, 長岡 由修, 石郷岡 哲郎, 齋藤 豪

    北海道産科婦人科学会会誌   64 ( 1 )   108 - 109   2020.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • 子宮内膜症及び腺筋症の合併が癒着胎盤を呈した妊娠の1例

    蛯谷 由真, 藤部 佑哉, 真里谷 奨, 水柿 祐子, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 石岡 伸一, 菅原 太郎, 杉田 真太郎, 長谷川 匡, 齋藤 豪

    北海道産科婦人科学会会誌   64 ( 1 )   114 - 114   2020.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 家族性に発生した処女膜閉鎖症例

    梅本 美菜, 鈴木 将裕, 鹿内 智史, 伊野 善彦, 杉田 菜穂子, 嶋田 浩志, 真里谷 奨, 遠藤 俊明, 齋藤 豪

    北海道産科婦人科学会会誌   64 ( 1 )   100 - 101   2020.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • A Proposal of Image Clustering Using YOLOv3 for Cervical Cytology

    南部優太, 真里谷奨, 真里谷奨, 新開翔太, 淺沼広子, 淺沼広子, 廣橋良彦, 齋藤豪, 鳥越俊彦, 佐藤生馬, 藤野雄一

    医療情報学連合大会論文集(CD-ROM)   40th   2020

  • コンパニオン診断保険適用前後の当科におけるBRCA変異検査状況に関する検討

    真里谷奨, 寺田倫子, 宮崎幸子, 石川亜貴, 岩崎雅宏, 齋藤豪, 櫻井晃洋

    日本遺伝性腫瘍学会学術集会プログラム・抄録集   26th   2020

  • 着床前診断を経て明らかとなった染色体均衡型構造異常を伴う不育症診療のピットフォール

    馬場剛, 遠藤俊明, 真里谷奨, 小川万梨絵, 森下美幸, 久野芳佳, 齋藤豪, 馬場剛

    日本人類遺伝学会大会(CD-ROM)   65th   2020

  • A case of congenital cystic adenomatoid marformation with extra-thoracic pulmonary sequestration

    染谷真行, 古来愛香, 新開翔太, 真里谷奨, 石岡伸一, 齋藤豪

    超音波医学 Supplement   47   2020

  • 妊娠中の広汎子宮頸部摘出術(RT)後子宮頸部細胞診における異型細胞の出現

    石岡伸一, 真里谷奨, 金美善, 新開翔太, 齋藤豪

    日本臨床細胞学会雑誌(Web)   59   2020

  • Deep Learning(YOLO)を用いた子宮頸部細胞診診断支援の有用性

    新開翔太, 真里谷奨, 真里谷奨, 郷久晴朗, 岩崎雅宏, 南部優太, 藤野雄一, 淺沼広子, 淺沼広子, 廣橋良彦, 鳥越俊彦, 齋藤豪

    日本臨床細胞学会雑誌(Web)   59   2020

  • Administration of methotrexate (MTX) for a patient with missed abortion after transabdominal cerclage (TAC)

    石堂茉泉, 石岡伸一, 藤部佑哉, 鈴木美紀, 嶋田浩志, 真里谷奨, 馬場剛, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   56 ( 1 )   2020

  • 新規シングルセルトランスクリプトーム解析手法を用いた子宮内膜癌の組織多様性の解析

    真里谷奨, 浅野拓也, 廣橋良彦, 橋本真一, 齋藤豪, 鳥越俊彦, 真里谷奨

    日本人類遺伝学会大会プログラム・抄録集   65th (CD-ROM)   2020

  • A case of rhabdomyolysis due to hypokalemia during pregnancy

    長尾沙智子, 馬場剛, 梅本美菜, 新開翔太, 鈴木将裕, 真里谷奨, 染谷真行, 森下美幸, 石岡伸一, 齋藤豪

    日本女性栄養・代謝学会誌   43回 ( 1 )   79 - 79   2019.9

     More details

  • 帝王切開後産科危機的出血に対して母体救命目的に子宮摘出を要した3症例の検討

    佐藤 由梨, 長尾 沙智子, 新開 翔太, 真里谷 奨, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   67回   75 - 75   2019.9

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    researchmap

  • 発症後早期の抗生剤治療が救命につながった激症分娩型A群連鎖球菌感染症

    石堂 茉泉, 嶋田 浩志, 倉 ありさ, 藤部 佑哉, 鈴木 美紀, 長尾 沙智子, 新開 翔太, 真里谷 奨, 染谷 真行, 森下 美幸, 馬場 剛, 石岡 伸一, 横田 伸一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   67回   61 - 61   2019.9

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 当院における超緊急帝王切開(NICE分類カテゴリー1)の母児転帰に関する検討

    新開 翔太, 真里谷 奨, 長尾 沙智子, 染谷 真行, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   67回   75 - 75   2019.9

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    researchmap

  • 妊娠前施行開腹子宮頸管縫縮術(TAC)の現状と産科予後を改善するための工夫

    石岡 伸一, 真里谷 奨, 水柿 祐子, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 齋藤 豪

    産婦人科手術   ( 30 )   128 - 128   2019.8

     More details

    Language:Japanese   Publisher:(株)メジカルビュー社  

    Ichushi

    researchmap

  • NGSDプロジェクトにおける領域横断的な遺伝カウンセリング研修の経験

    真里谷 奨, 宮崎 幸子, 寺田 倫子, 水上 都, 石川 亜貴, 馬場 剛, 石岡 伸一, 齋藤 豪, 櫻井 晃洋

    日本遺伝カウンセリング学会誌   40 ( 2 )   177 - 177   2019.7

     More details

    Language:Japanese   Publisher:(一社)日本遺伝カウンセリング学会  

    Ichushi

    researchmap

  • NT肥厚を契機に診断された10番染色体長腕末端欠失の一例

    川俣 あかり, 水内 将人, 斉藤 公人, 水柿 祐子, 真里谷 奨, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本遺伝カウンセリング学会誌   40 ( 2 )   114 - 114   2019.7

     More details

    Language:Japanese   Publisher:(一社)日本遺伝カウンセリング学会  

    Ichushi

    researchmap

  • リステリア菌血症により流産に至った1例

    藤部 佑哉, 真里谷 奨, 嶋田 浩志, 山中 郁仁, 水内 将人, 寺本 瑞絵, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   55 ( 2 )   530 - 530   2019.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 当院の糖代謝異常合併妊婦における分娩時血糖管理の有効性の検討

    鈴木 将裕, 真里谷 奨, 杉田 奈穂子, 斎藤 豪

    日本周産期・新生児医学会雑誌   55 ( 2 )   533 - 533   2019.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 進行子宮頸癌合併妊娠の検討

    寺本 瑞絵, 寺田 倫子, 藤部 佑哉, 真里谷 奨, 水内 将人, 馬場 剛, 石岡 伸一, 齊藤 豪

    日本周産期・新生児医学会雑誌   55 ( 2 )   480 - 480   2019.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • Clear cell borderline adenofibromaの2例

    伊野 善彦, 松浦 基樹, 真里谷 奨, 郷久 晴朗, 齋藤 豪

    日本婦人科腫瘍学会雑誌   37 ( 3 )   557 - 557   2019.6

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • 妊娠子宮頸部静脈瘤破裂に対し交差二重マクドナルド頸管縫縮術を施行し止血し得た一例

    真里谷 奨, 藤部 佑哉, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   55 ( 2 )   652 - 652   2019.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 妊娠中の広汎子宮頸部摘出術 腟式トラケレクトミー

    齋藤 豪, 岩崎 雅宏, 松浦 基樹, 郷久 晴朗, 玉手 雅人, 真里谷 奨, 石岡 伸一

    日本婦人科腫瘍学会雑誌   37 ( 3 )   377 - 377   2019.6

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • 当院における18トリソミー症例の検討

    石堂 茉泉, 石岡 伸一, 真里谷 奨, 黒田 敬史, 水内 将人, 五十嵐 リサ, 馬場 剛, 小林 正樹, 齋藤 剛

    日本周産期・新生児医学会雑誌   55 ( 2 )   443 - 443   2019.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 異なる転機をたどったchorionic bumpの2例

    藤部 佑哉, 水内 将人, 嶋田 浩志, 真里谷 奨, 野呂 薫, 山中 郁仁, 寺本 瑞絵, 馬場 剛, 石岡 伸一, 齋藤 豪

    超音波医学   46 ( Suppl. )   S726 - S726   2019.4

     More details

    Language:Japanese   Publisher:(公社)日本超音波医学会  

    Ichushi

    researchmap

  • 当院産婦人科領域における菌血症症例に関する検討

    真里谷 奨, 伊野 善彦, 高橋 聡

    感染症学雑誌   93 ( 臨増 )   390 - 390   2019.3

     More details

    Language:Japanese   Publisher:(一社)日本感染症学会  

    Ichushi

    researchmap

  • 癒着胎盤に対する両側総腸骨動脈バルーン閉塞術(CIABO)下の帝王切開中に総腸骨動脈解離を発症した一例

    斉藤 公仁, 真里谷 奨, 水柿 祐子, 藤部 佑哉, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 660   2019.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 広汎子宮頸部摘出術(RT)後の双胎妊娠の一例

    水柿 祐子, 石岡 伸一, 藤部 佑哉, 真里谷 奨, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 齋藤 豪

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 391   2019.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 同胞の治療が契機となり判明した姉妹発症の処女膜閉鎖症

    鈴木 将裕, 真里谷 奨, 梅本 美菜, 鹿内 智史, 杉田 奈穂子, 嶋田 浩志, 玉手 雅人, 遠藤 俊明, 斎藤 豪

    産科と婦人科   86 ( 2 )   271 - 275   2019.2

     More details

    Language:Japanese   Publisher:(株)診断と治療社  

    Ichushi

    researchmap

  • 子宮頸部静脈瘤からの出血に対し子宮頸管縫縮術が有効であった一例

    川俣 あかり, 斉藤 公仁, 水柿 祐子, 藤部 佑哉, 真里谷 奨, 水内 将人, 森下 美幸, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 656   2019.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • ミスマッチ修復遺伝子欠損に伴う癌種間の免疫逃避機構プロファイルの違いに関する検討

    真里谷奨, 真里谷奨, 久保輝文, 廣橋良彦, 鳥越俊彦, 齋藤豪, 櫻井晃洋

    日本人類遺伝学会大会プログラム・抄録集   64th   2019

  • 当科において妊娠初期子宮頸部細胞診HSIL/ASC-H以上を認めた症例の検討

    真里谷奨, 石岡伸一, 玉手雅人, 郷久晴朗, 松浦基樹, 岩崎雅宏, 齋藤豪

    日本臨床細胞学会雑誌(Web)   58   2019

  • 子宮体癌と大腸癌におけるミスマッチ修復タンパクおよびHLA Class I分子の異なる発現状況に関する検討

    真里谷奨, 久保輝文, 廣橋良彦, 鳥越俊彦, 齋藤豪

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   51st   2019

  • 転移性女性生殖器がんにおける臨床像と捺印細胞像

    玉手雅人, 松浦基樹, 長尾沙智子, 西村庸子, 真里谷奨, 寺田倫子, 郷久晴朗, 杉田真太朗, 岩崎雅宏, 齋藤豪

    日本臨床細胞学会雑誌(Web)   58   2019

  • CIN3における子宮頸部レーザー蒸散術後の異型細胞存続例について

    黒田 敬史, 西川 鑑, 真里谷 奨, 山中 郁仁, 小松 健一郎, 杉田 有子, 本間 則之, 高桑 康成, 佐藤 昌明

    北海道臨床細胞学会会報   27   5 - 7   2018.11

     More details

    Language:Japanese   Publisher:北海道臨床細胞学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 当科における妊娠中の広汎子宮頸部摘出術施行症例の妊娠経過の検討

    石岡 伸一, 水柿 祐子, 藤部 佑哉, 真里谷 奨, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 斎藤 豪

    日本癌治療学会学術集会抄録集   56回   P28 - 1   2018.10

     More details

    Language:English   Publisher:(一社)日本癌治療学会  

    Ichushi

    researchmap

  • 当科におけるLSIL以上の細胞診異常妊婦の経過

    石岡 伸一, 真里谷 奨, 金 美善, 玉手 雅人, 松浦 基樹, 黒田 敬史, 郷久 晴朗, 寺本 瑞絵, 岩崎 雅宏, 齋藤 豪

    日本臨床細胞学会雑誌   57 ( Suppl.2 )   673 - 673   2018.10

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • 当周産期センターにおける子宮内胎児死亡症例を含む無痛分娩の実際

    水内 将人, 君塚 基修, 木井 菜摘, 水柿 祐子, 藤部 佑哉, 真里谷 奨, 川俣 あかり, 森下 美幸, 馬場 剛, 石岡 伸一, 斎藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   66回   0075 - 0075   2018.9

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    researchmap

  • マイクロサテライト不安定性およびHLAクラスI分子低発現の子宮内膜癌における臨床的意義(Clinical implications of microsatellite instability and HLA Class I downregulation in endometrial cancer)

    真里谷 奨, 廣橋 良彦, 玉手 雅人, 郷久 晴朗, 久保 輝文, 寺本 瑞絵, 岩崎 雅宏, 鳥越 俊彦, 齋藤 豪

    日本癌学会総会記事   77回   518 - 518   2018.9

     More details

    Language:English   Publisher:(一社)日本癌学会  

    Ichushi

    researchmap

  • 癒着胎盤を呈した子宮内膜症及び腺筋症合併妊娠の一例

    蛯谷 由真, 藤部 佑哉, 水柿 裕子, 真里谷 奨, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 石岡 伸一, 斎藤 正一, 菅原 太郎, 杉田 真太朗, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   66回   0076 - 0076   2018.9

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    researchmap

  • 先天性アンチトロンビン欠乏症妊婦に遺伝子組み換えアンチトロンビン製剤を用い合併症なく生児を得た1例

    藤部 佑哉, 真里谷 奨, 蛯谷 由真, 水柿 裕子, 川俣 あかり, 水内 将人, 森下 美幸, 馬場 剛, 石岡 伸一, 吉田 正宏, 井山 諭, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   66回   0094 - 0094   2018.9

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    researchmap

  • 帝王切開瘢痕部からの反復性多量出血に対し腹腔鏡下瘢痕切除を行った一例

    真里谷 奨, 梅本 美菜, 杉田 奈穂子, 鈴木 将裕, 郷久 晴朗, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   296 - 296   2018.8

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    researchmap

  • 腹腔鏡下子宮全摘出術後に再発したSTUMPの一例

    郷久 晴朗, 岩崎 雅宏, 阿部 秀悦, 秋元 太志, 鹿内 智史, 西村 庸子, 玉手 雅人, 真里谷 奨, 松浦 元樹, 寺本 瑞絵, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   255 - 255   2018.8

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    researchmap

  • 経口抗菌薬を用いた妊娠中の産道Streptococcus agalactiae除菌の試みと腟内細菌叢との関連に関する検討

    真里谷 奨, 鹿内 智史, 嶋田 浩志, 杉田 奈穗子, 鈴木 将裕, 野手 健司, 鷲見 亮太, 齋藤 豪

    帯広協会病院医誌   3   17 - 27   2018.7

     More details

    Language:Japanese   Publisher:(福)北海道社会事業協会帯広病院  

    Ichushi

    researchmap

  • ヒト絨毛癌細胞株BeWoにおけるMetforminの小胞体ストレス応答と胎盤増殖因子に対する役割

    鈴木 将裕, 水内 将人, 杉田 奈穂子, 真里谷 奨, 齋藤 豪

    日本周産期・新生児医学会雑誌   54 ( 2 )   552 - 552   2018.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 出生前診断が困難であった羊水過多を伴う気管無形成の一例

    藤部 佑哉, 水内 将人, 今 沙織, 真里谷 奨, 黒田 敬史, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   54 ( 2 )   597 - 597   2018.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 経腟分娩後の予防的抗菌薬適正使用に関する検討

    真里谷 奨, 杉田 奈穂子, 鈴木 将裕, 藤部 佑哉, 齋藤 豪

    日本周産期・新生児医学会雑誌   54 ( 2 )   743 - 743   2018.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 経腟分娩後の予防的抗菌薬ルーチン投与廃止と産褥期感染の検討

    真里谷 奨, 中田 富子, 杉田 奈穂子, 鈴木 将裕, 齋藤 豪

    日本化学療法学会雑誌   66 ( Suppl.A )   317 - 317   2018.4

     More details

    Language:Japanese   Publisher:(公社)日本化学療法学会  

    Ichushi

    researchmap

  • 非医原性parasitic leiomyomaの一例

    嶋田 浩志, 阿部 秀悦, 鹿内 智史, 真里谷 奨, 橋本 卓, 阿部 厚憲, 郷久 晴朗, 齋藤 豪

    北海道産科婦人科学会会誌   62 ( 1 )   21 - 24   2018.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 子宮頸部細胞診ASC-US症例における従来法と液状検体法による比較検討

    鹿内 智史, 真里谷 奨, 嶋田 浩志, 玉手 雅人, 黒田 敬史, 齋藤 豪

    北海道産科婦人科学会会誌   62 ( 1 )   172 - 172   2018.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • 卵巣腫瘍および腸管型GISTとの鑑別に苦慮した非医原性腸管parasitic leiomyoma

    鈴木 麻由, 嶋田 浩志, 阿部 秀悦, 鹿内 智史, 真里谷 奨, 橋本 卓, 阿部 厚憲, 齋藤 豪

    北海道産科婦人科学会会誌   62 ( 1 )   193 - 193   2018.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • 子宮体癌由来のクローン株解析は癌幹細胞の機能的多様性を明らかにした

    田渕 雄大, 鈴木 利理, 玉手 雅人, 真里谷 奨, 浅野 拓也, 水内 将人, 齋藤 豪

    日本産科婦人科学会雑誌   70 ( 2 )   655 - 655   2018.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    researchmap

  • 当科における卵管切除症例の異型性病変に対する臨床病理学的検討

    杉田 奈穂子, 真里谷 奨, 鈴木 将裕, 郷久 晴朗, 齋藤 豪

    日本産科婦人科学会雑誌   70 ( 2 )   859 - 859   2018.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    researchmap

  • 当科におけるLSIL以上の細胞診異常妊娠の経過

    石岡伸一, 真里谷奨, 金美善, 玉手雅人, 松浦基樹, 黒田敬史, 郷久晴朗, 寺本瑞絵, 岩崎雅宏, 齋藤豪

    日本臨床細胞学会雑誌(Web)   57   2018

  • 急性虫垂炎との鑑別に難渋し診断的腹腔鏡にて卵管留血腫の茎捻転と判明した女児の1例

    鹿内 智史, 真里谷 奨, 嶋田 浩志, 郷久 晴朗, 高橋 徹, 齋藤 豪

    産科と婦人科   84 ( 12 )   1513 - 1517   2017.12

     More details

    Language:Japanese   Publisher:(株)診断と治療社  

    Ichushi

    researchmap

  • 虫垂炎との鑑別に難渋し診断的腹腔鏡で判明した左卵管留血腫の1例

    鹿内 智史, 山崎 智子, 幅田 周太郎, 真里谷 奨, 斎藤 剛

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   65回   71 - 71   2017.9

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    researchmap

  • 腹腔鏡下子宮全摘術時のリスク低減卵管切除に関する検討

    真里谷 奨, 鹿内 智史, 嶋田 浩志, 杉田 奈穂子, 鈴木 将裕, 三浦 一郎, 三浦 千砂子, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   1219 - 1219   2017.8

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    researchmap

  • 異なる転帰をたどった周郭胎盤の2例

    嶋田 浩志, 真里谷 奨, 高田 さくら, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   53 ( 2 )   693 - 693   2017.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 不妊症精査を契機に診断された子宮結核および結核性ぶどう膜炎の一例

    真里谷 奨, 阿部 秀悦, 鹿内 智史, 嶋田 浩志, 白枝 友子, 田邊 章浩, 本間 寛之, 齋藤 豪

    日本産婦人科感染症学会学術講演会プログラム・抄録集   34回   51 - 51   2017.5

     More details

    Language:Japanese   Publisher:(一社)日本産婦人科感染症学会  

    Ichushi

    researchmap

  • 超音波検査により内膜症性嚢胞と誤認していたOHVIRA症候群に伴う腟留血腫の1例

    嶋田 浩志, 鹿内 智史, 真里谷 奨, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    超音波医学   44 ( Suppl. )   S680 - S680   2017.4

     More details

    Language:Japanese   Publisher:(公社)日本超音波医学会  

    Ichushi

    researchmap

  • 産科危機的出血を来した子宮弛緩症に対しB-Lynch法を行い出血コントロールが得られた1例

    阿部 秀悦, 黒田 敬史, 真里谷 奨, 遠藤 俊明, 齋藤 豪

    北海道産科婦人科学会会誌   61 ( 1 )   60 - 61   2017.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • 経口抗生剤を用いた予防的産道Group B Streptococcus除菌の試みと腟内細菌叢との関連について

    真里谷 奨, 中田 富子, 鹿内 智史, 嶋田 浩志, 齋藤 豪

    日本化学療法学会雑誌   65 ( Suppl.A )   262 - 262   2017.3

     More details

    Language:Japanese   Publisher:(公社)日本化学療法学会  

    Ichushi

    researchmap

  • 治療抵抗性婦人科がん幹細胞におけるストレス応答分子機序解析

    村井 愛子, 廣橋 良彦, 田渕 雄大, 安田 和世, 浅野 拓也, 真里谷 奨, 鳥越 俊彦

    日本病理学会会誌   106 ( 1 )   400 - 400   2017.3

     More details

    Language:Japanese   Publisher:(一社)日本病理学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 全腹腔鏡下子宮全摘出術における腟からの摘出物回収方法の工夫と手術成績

    西川 鑑, 水柿 祐子, 黒田 敬史, 清水 亜由美, 山中 郁仁, 二瓶 岳人, 真里谷 奨

    日本産科婦人科学会雑誌   69 ( 2 )   959 - 959   2017.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • CIN3における子宮頸部レーザー蒸散術後の異型細胞存続例について

    黒田 敬史, 西川 鑑, 真里谷 奨, 小松 健一郎, 杉田 有子, 本間 則之, 高桑 康成, 佐藤 昌明

    日本臨床細胞学会雑誌   55 ( Suppl.2 )   582 - 582   2016.10

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • 子宮頸部細胞診ASC-US症例における従来法と液状検体法による比較検討

    鹿内 智史, 真里谷 奨, 嶋田 浩志, 玉手 雅人, 黒田 敬史, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   64回   89 - 89   2016.9

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    researchmap

  • 卵巣腫瘍および腸管型GISTとの鑑別に苦慮した非医原性腸管parasitic leiomyoma

    鈴木 麻由, 嶋田 浩志, 阿部 秀悦, 鹿内 智史, 真里谷 奨, 橋本 卓, 阿部 厚憲, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   64回   116 - 116   2016.9

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    researchmap

  • 腹腔鏡下に診断し得た女児の左卵管留血腫

    鹿内 智史, 嶋田 浩志, 真里谷 奨, 郷久 晴朗, 高橋 徹, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   32 ( Suppl.I )   246 - 246   2016.8

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    researchmap

  • 切迫早産治療中に塩酸リトドリンによる薬剤性無顆粒球症および薬剤性肝障害を発症し周産期管理に苦慮した一例

    阿部 秀悦, 真里谷 奨, 黒田 敬史, 齋藤 豪

    帯広協会病院医誌   1   71 - 79   2016.5

     More details

    Language:Japanese   Publisher:(福)北海道社会事業協会帯広病院  

    Ichushi

    researchmap

  • 産後子宮不全破裂に対する子宮全摘出後のダグラス窩膿瘍に対し経腟的ドレナージおよび腹腔内洗浄が有効であった一例

    真里谷 奨, 中田 富子, 黒田 敬史, 阿部 秀悦, 橋本 卓, 齋藤 豪

    日本化学療法学会雑誌   64 ( Suppl.A )   207 - 207   2016.5

     More details

    Language:Japanese   Publisher:(公社)日本化学療法学会  

    Ichushi

    researchmap

  • 子宮体癌初代培養細胞株における癌幹細胞の分離同定とその解析

    田渕 雄大, 廣橋 良彦, 真里谷 奨, 浅野 拓也, 黒田 敬史, 齋藤 豪, 鳥越 俊彦

    日本病理学会会誌   105 ( 1 )   397 - 398   2016.4

     More details

    Language:Japanese   Publisher:(一社)日本病理学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 当院にて手術加療した子宮頸部異形成334例における術前術後のHPV型別感染状況に関する検討

    真里谷 奨, 山下 亜矢

    感染症学雑誌   90 ( 臨増 )   280 - 280   2016.3

     More details

    Language:Japanese   Publisher:(一社)日本感染症学会  

    Ichushi

    J-GLOBAL

    researchmap

  • CIN3に対するレーザー蒸散と円錐切除の長期予後の比較

    西川 鑑, 真里谷 奨, 黒川 晶子, 清水 亜由美, 池田 桂子, 二瓶 岳人

    日本産科婦人科学会雑誌   68 ( 2 )   689 - 689   2016.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • CIN3における子宮頸部レーザー蒸散術後の異型細胞存続例について

    黒田敬史, 西川鑑, 真里谷奨, 小松健一郎, 杉田有子, 本間則之, 高桑康成, 佐藤昌明

    日本臨床細胞学会雑誌(Web)   55   2016

  • ISP-37-2 A case report of multiple adenomyotic cysts derived from uterine serosa(Group 37 Women's Health 2,International Session Poster) :

    Kuroda Takafumi, Satohisa Seiro, Abe Shuetsu, Mariya Tasuku, Shinkai Shota, Endo Toshiaki, Saito Tsuyoshi

    68 ( 2 )   584 - 584   2016

  • ISP-8-6 Isolation and characterization of cancer stem-like cells from primary human endometrioid adenocarcinoma(Group 8 Endometrial Cancer 3,International Session Poster) :

    Tabuchi Yuta, Mariya Tasuku, Asano Takuya, Kuroda Takahumi, Mizuuchi Masahito, Satohisa Seiro, Teramoto Mizue, Tanaka Ryoichi, Iwasaki Masahiro, Saito Tsuyoshi

    68 ( 2 )   500 - 500   2016

  • The property of ovarian cancer stem-like cells and the prospect for immunotherapy targeted cancer stem-like cells

    Takafumi Kuroda, Yoshihiko Hirohashi, Toshihiko Torigoe, Tasuku Mariya, Takuya Asano, Yudai Tabuchi, Masahito Mizuuchi, Masahiro Iwasaki, Noriyuki Sato, Tsuyoshi Saito

    ANNALS OF ONCOLOGY   26   27 - 27   2015.11

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • BORIS variant subfamily 6は癌幹細胞性に関与し免疫療法の標的となりうる

    浅野 拓也, 廣橋 良彦, 真里谷 奨, 黒田 敬史, 浅沼 広子, 鳥越 俊彦, 齋藤 豪

    日本癌学会総会記事   74回   P - 1233   2015.10

     More details

    Language:English   Publisher:(一社)日本癌学会  

    Ichushi

    researchmap

  • sarcomatous overgrowthを伴った子宮体部原発腺肉腫の1例

    阿部 秀悦, 黒田 敬史, 藤部 佑哉, 新開 翔太, 恐神 博行, 真里谷 奨, 竹浪 奈緒子, 斉藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   63回   90 - 90   2015.9

     More details

    Language:Japanese   Publisher:東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

    researchmap

  • 癌精巣抗原BORIS sf6は婦人科癌幹細胞性に関与し免疫療法のターゲットになりうる

    浅野 拓也, 廣橋 良彦, 真里谷 奨, 黒田 敬史, 浅沼 広子, 鳥越 俊彦, 齋藤 豪, 佐藤 昇志

    日本病理学会会誌   104 ( 1 )   301 - 301   2015.3

     More details

    Language:Japanese   Publisher:(一社)日本病理学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 大腸がん幹細胞新規癌抗原OR7C1の臨床予後に関する検討

    守田 玲菜, 廣橋 良彦, 鳥越 俊彦, 高橋 あかり, 真里谷 奨, 浅沼 広子, 照井 健, 高橋 典彦, 武富 紹信, 佐藤 昇志

    日本病理学会会誌   104 ( 1 )   387 - 387   2015.3

     More details

    Language:Japanese   Publisher:(一社)日本病理学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 卵巣癌幹細胞の幹細胞性制御におけるMMP10の作用

    真里谷 奨, 廣橋 良彦, 田渕 雄大, 浅野 拓也, 黒田 敬史, 水内 将人, 安田 和世, 鳥越 俊彦, 齋藤 豪, 佐藤 昇志

    日本病理学会会誌   104 ( 1 )   302 - 302   2015.3

     More details

    Language:Japanese   Publisher:(一社)日本病理学会  

    Ichushi

    J-GLOBAL

    researchmap

  • ISP-7-5 BORIS variants are expressed in gynecological cancer stem cells-specific manner and associated with stemness(Group 7 Oncology 7,IS Poster,International Session) :

    Asano Takuya, Mariya Tasuku, Kuroda Takafumi, Mizuuchi Masahito, Takahashi Madoka, Satohisa Seiro, Teramoto Mizue, Tanaka Ryoichi, Iwasaki Masahiro, Saito Tsuyoshi

    67 ( 2 )   1021 - 1021   2015

  • MMP10 REGULATES STEMNESS OF OVARIAN CANCER STEM CELLS

    T. Mariya, Y. Hirohashi, T. Asano, T. Kuroda, M. Mizuuchi, T. Torigoe, T. Saito, N. Sato

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   24 ( 9 )   98 - 98   2014.11

     More details

    Language:English   Publishing type:Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 当院における260例のASC-US症例の臨床病理学的検討

    齋藤 雅恵, 鈴木 利理, 真里谷 奨, 小松 健一郎, 杉田 有子, 本間 則之, 佐藤 昌明, 高桑 康成, 西川 鑑

    日本臨床細胞学会雑誌   53 ( Suppl.2 )   546 - 546   2014.10

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • 婦人科癌における癌精巣抗原BORISの発現ならびに癌幹細胞性の検討(Expression and characterization of the cancer/testis/stem antigen BORIS in gynecologic cancer stem cells)

    浅野 拓也, 廣橋 良彦, 真里谷 奨, 黒田 敬史, 浅沼 広子, 鳥越 俊彦, 齋藤 豪, 佐藤 昇志

    日本癌学会総会記事   73回   P - 1164   2014.9

     More details

    Language:English   Publisher:(一社)日本癌学会  

    Ichushi

    researchmap

  • 卵巣癌幹細胞におけるMMP10による幹細胞性の制御について(MMP10 regulates stemness of ovarian cancer stem cells)

    真里谷 奨, 廣橋 良彦, 浅野 拓也, 黒田 敬史, 水内 将人, 鳥越 俊彦, 齋藤 豪, 佐藤 昇志

    日本癌学会総会記事   73回   P - 1162   2014.9

     More details

    Language:English   Publisher:(一社)日本癌学会  

    Ichushi

    researchmap

  • V-Locクロージャーデバイスを用いたTLHにおける腟断端縫合法とその成績

    西川 鑑, 鈴木 利理, 齋藤 雅恵, 真里谷 奨, 川俣 あかり, 清水 亜由美, 二瓶 岳人

    日本産科婦人科内視鏡学会雑誌   30 ( Suppl.I )   233 - 233   2014.8

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 特殊組織型子宮体癌症例の増加と進行期・予後に関わる危険因子の検討

    郷久 晴朗, 真里谷 奨, 玉手 雅人, 幅田 周太郎, 田渕 雄大, 松浦 基樹, 秋元 太志, 寺本 瑞絵, 鈴木 美和, 高橋 円, 田中 綾一, 岩崎 雅宏, 齋藤 豪

    日本婦人科腫瘍学会雑誌   32 ( 3 )   508 - 508   2014.6

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • Diffusion-weighted imaging and apparent diffusion coefficient values in cervical cancer of the uterus

    81 ( 6 )   773 - 777   2014.6

     More details

  • 上皮性卵巣癌122例のHLA Class I発現およびCTL腫瘍内浸潤の臨床的因子との関連

    真里谷 奨, 廣橋 良彦, 浅野 拓也, 黒田 敬史, 安田 和世, 鳥越 俊彦, 齋藤 豪, 佐藤 昇志

    日本病理学会会誌   103 ( 1 )   371 - 371   2014.3

     More details

    Language:Japanese   Publisher:(一社)日本病理学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 卵巣癌症例の血小板数と腹水貯留の関連性について

    沼田 佳苗, 西川 鑑, 真里谷 奨, 川俣 あかり, 二瓶 岳人

    北海道産科婦人科学会会誌   58 ( 1 )   21 - 24   2014.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • 卵巣癌患者と血小板値に関する検討

    沼田 佳苗, 西川 鑑, 真里谷 奨, 川俣 あかり, 二瓶 岳人

    北海道産科婦人科学会会誌   58 ( 1 )   111 - 111   2014.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • 婦人科癌における癌精巣抗原BORISの発現ならびに癌幹細胞性の検討

    浅野 拓也, 廣橋 良彦, 真里谷 奨, 黒田 敬史, 鳥越 俊彦, 齋藤 豪, 佐藤 昇志

    日本病理学会会誌   103 ( 1 )   266 - 266   2014.3

     More details

    Language:Japanese   Publisher:(一社)日本病理学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 当院における40歳以上の高年出産216例の検討

    沼田 佳苗, 西川 鑑, 真里谷 奨, 川俣 あかり, 二瓶 岳人, 荒木 奈緒

    産婦人科の実際   63 ( 1 )   115 - 119   2014.1

     More details

    Language:Japanese   Publisher:金原出版(株)  

    Ichushi

    researchmap

  • 腹膜透析中に感染性子宮内膜症性嚢胞の破裂を認めた1例

    真里谷奨, 真里谷奨, 鈴木利理, 齋藤雅恵, 清水亜由美, 二瓶岳人, 西川鑑, 齋藤豪

    日本産婦人科感染症研究会学術講演会プログラム・講演抄録集   31st   2014

  • 卵巣未熟奇形腫の治療後に発生したGrowing teratoma syndromeに対し腹腔鏡下病巣切除を施行した一例

    真里谷 奨, 西川 鑑, 沼田 佳苗, 川俣 あかり, 二瓶 岳人, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   29 ( 1 )   158 - 162   2013.11

  • 癌幹細胞において恒常的発現と活性化を示すHSF1遺伝子は、がん治療ターゲットとなる可能性を有する(Constitutive expression of heat shock factor1(HSF1) in cancer stem-like cells/cancer-initiating cells)

    安田 和世, 鳥越 俊彦, 廣橋 良彦, 黒田 尊史, 松崎 純一, 真里谷 奨, 浅野 拓也, 高橋 あかり, 佐藤 昇志

    日本癌学会総会記事   72回   141 - 141   2013.10

     More details

    Language:English   Publisher:(一社)日本癌学会  

    Ichushi

    researchmap

  • 卵巣癌症例の血小板数と腹水の貯留の関連

    沼田 佳苗, 西川 鑑, 真里谷 奨, 川俣 あかり, 二瓶 岳人

    日本婦人科腫瘍学会雑誌   31 ( 3 )   474 - 474   2013.6

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • 最近経験した低悪性度子宮内膜間質肉腫の6症例

    西川 鑑, 沼田 佳苗, 真里谷 奨, 川俣 あかり, 二瓶 岳人

    日本婦人科腫瘍学会雑誌   31 ( 3 )   492 - 492   2013.6

     More details

    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

    Ichushi

    researchmap

  • タモキシフェン投与により出現する子宮頸部の異型細胞について

    西川 鑑, 真里谷 奨, 沼田 佳苗, 川俣 あかり, 小松 健一郎, 杉田 有子, 本間 則之, 高桑 康成, 佐藤 昌明

    日本臨床細胞学会雑誌   52 ( Suppl.1 )   184 - 184   2013.5

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

  • ヒト上皮性卵巣癌におけるアルデヒド脱水素酵素遺伝子ALDH1の発現とstemnessの検討

    黒田 敬史, 廣橋 良彦, 鳥越 俊彦, 安田 和世, 浅沼 広子, 高橋 あかり, 浅野 拓也, 真里谷 奨, 水内 将人, 斉藤 豪, 佐藤 昇志

    日本病理学会会誌   102 ( 1 )   348 - 348   2013.4

     More details

    Language:Japanese   Publisher:(一社)日本病理学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 筋腫分娩となった子宮体部筋層内筋腫に対して、子宮頸部縦切開による腟式子宮筋腫核出術を施行した1例

    佐藤 賢一郎, 真里谷 奨, 岩渕 有紗, 水内 英充, 水内 将人, 北島 義盛

    産科と婦人科   80 ( 4 )   531 - 536   2013.4

     More details

    Language:Japanese   Publisher:(株)診断と治療社  

    Ichushi

    researchmap

  • CIN 397例に対する子宮頸部円錐切除術ならびにレーザー蒸散術の治療成績

    真里谷 奨, 沼田 佳苗, 川俣 あかり, 二瓶 岳人, 西川 鑑

    日本産科婦人科学会雑誌   65 ( 2 )   701 - 701   2013.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    J-GLOBAL

    researchmap

  • 当院における40歳以上の高年出産216例の検討

    沼田 佳苗, 西川 鑑, 真里谷 奨, 川俣 あかり, 二瓶 岳人

    日本産科婦人科学会雑誌   65 ( 2 )   624 - 624   2013.2

     More details

    Language:Japanese   Publisher:(公社)日本産科婦人科学会  

    Ichushi

    researchmap

  • P1-8-6 低悪性度子宮内膜間質肉腫の5症例(Group 8 子宮体部腫瘍・症例,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

    川俣 あかり, 西川 鑑, 沼田 佳苗, 真里谷 奨, 二瓶 岳人

    日本産科婦人科學會雜誌   65 ( 2 )   550 - 550   2013

     More details

    Language:Japanese   Publisher:日本産科婦人科学会  

    Other Link:: https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=449986

    researchmap

  • ISP-17-1 Isolation and analysis of cancer stem-like cells from primary epithelial ovarian cancer(Group 17 Oncology 8,IS Poster,International Session) :

    Kuroda Takafumi, Mizuuchi Masahito, Asano Takuya, Mariya Tasuku, Tanaka Ryouichi, Iwasaki Masahiro, Suzuki Takahiro, Fukunaka Noriyoshi, Tanaka Satoshi, Ito Eiki, Saito Tsuyoshi

    65 ( 2 )   1024 - 1024   2013

  • P1-27-1 マイクロ波子宮内膜焼灼術の合併症を回避するための工夫(Group 27 生殖・手術,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

    西川 鑑, 沼田 佳苗, 真里谷 奨, 川俣 あかり, 二瓶 岳人

    日本産科婦人科學會雜誌   65 ( 2 )   601 - 601   2013

     More details

    Language:Japanese   Publisher:日本産科婦人科学会  

    Other Link:: https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=450137

    J-GLOBAL

    researchmap

  • 子宮体部上部横切開の経験

    佐藤 賢一郎, 真里谷 奨, 田原 泰夫, 川村 健太郎, 小杉 陽祐, 小杉 未奈, 東海林 黎吉, 北島 義盛

    産科と婦人科   79 ( 6 )   795 - 800   2012.6

     More details

    Language:Japanese   Publisher:(株)診断と治療社  

    Ichushi

    researchmap

  • ヘテロ型先天性プロテインC欠損症合併妊娠に対し抗凝固療法を用いて周産期管理を行った一例

    真里谷 奨, 遠藤 俊明, 杉尾 明香, 森下 美幸, 明石 祐史, 馬場 剛, 山中 郁仁, 石岡 伸一, 齋藤 豪

    北海道産科婦人科学会会誌   56 ( 1 )   38 - 42   2012.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • 広範囲に及ぶ下腿潰瘍を呈した巨大卵巣腫瘍の1例

    茅橋 佳代, 梅村 康太, 杉尾 明香, 池田 桂子, 真里谷 奨, 幅田 周太朗, 黒田 敬史, 田中 綾一, 鈴木 孝浩, 岩崎 雅宏, 伊東 英樹, 齋藤 豪

    北海道産科婦人科学会会誌   56 ( 1 )   73 - 73   2012.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • 当科における卵巣悪性胚細胞腫瘍の治療成績

    玉手 雅人, 田中 綾一, 真里谷 奨, 幅田 周太朗, 黒田 敬史, 鈴木 美和, 梅村 康太, 岩崎 雅宏, 鈴木 孝浩, 伊東 英樹, 齋藤 豪

    北海道産科婦人科学会会誌   56 ( 1 )   75 - 76   2012.3

     More details

    Language:Japanese   Publisher:北海道産科婦人科学会  

    Ichushi

    researchmap

  • P2-21-6 種々の合併症を有する高齢完全子宮脱症例に対するGoodall-Power手術の有用性について(Group77 骨盤臓器脱1,一般演題)

    真里谷 奨, 佐藤 賢一郎

    日本産科婦人科學會雜誌   64 ( 2 )   661 - 661   2012

     More details

    Language:Japanese   Publisher:日本産科婦人科学会  

    Other Link:: https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=448616

    CiNii Research

    researchmap

  • 当科における腟式子宮筋腫核出術とSILS LAVMについて

    真里谷 奨, 佐藤 賢一郎

    日本産科婦人科内視鏡学会雑誌   27 ( 1 )   189 - 189   2011.8

     More details

    Language:Japanese   Publisher:(一社)日本産科婦人科内視鏡学会  

    Ichushi

    researchmap

  • 胎児水腫を来たした絨毛血管腫の一例

    真里谷 奨, 高橋 円, 高田 さくら, 杉尾 明香, 長澤 邦彦, 林 卓宏, 石岡 伸一, 遠藤 俊明, 齊藤 豪

    日本周産期・新生児医学会雑誌   47 ( 2 )   472 - 472   2011.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 腟式広汎子宮頸部切断術後妊娠管理のポイント

    高田 さくら, 石岡 伸一, 真里谷 奨, 岩見 菜々子, 杉尾 明香, 水内 将人, 高橋 円, 長澤 邦彦, 林 卓宏, 遠藤 俊明, 斉藤 豪

    日本周産期・新生児医学会雑誌   47 ( 2 )   328 - 328   2011.6

     More details

    Language:Japanese   Publisher:(一社)日本周産期・新生児医学会  

    Ichushi

    researchmap

  • 腹水細胞診が再発治療法決定に有効であった一例

    真里谷 奨, 鈴木 孝浩, 鈴木 美和, 松浦 基樹, 田中 綾一, 藤井 美穂, 梅村 康太, 伊東 英樹, 斉藤 豪

    日本臨床細胞学会雑誌   49 ( Suppl.2 )   551 - 551   2010.9

     More details

    Language:Japanese   Publisher:(公社)日本臨床細胞学会  

    Ichushi

    researchmap

▼display all

Awards

  • JSOG Congress Encouragement Award

    2025.5   Application of long read sequencers for preclinical work up of preimpl antation genetic testing for monogenic/single-gene defects

     More details

  • 優秀演題賞

    2024.9   第56回日本臨床分子形態学会総会・学術集会   対照学習とアテンション機構を用いた細胞診断支援におけるExplainable AI構築について

    真里谷奨, 南部優太, 藤野雄一, 齋藤豪 他

     More details

  • 優秀ポスター演題賞

    2024.6   第6回日本メディカルAI学会学術集会   子宮内膜がんにおける複数の深層学習アルゴリズムの比較を通した病理組織スライド画像からのMMRステータス推定について

    梅本美菜, 真里谷奨 他

     More details

  • 優秀演題賞

    2024.5   第4回日本遺伝性乳癌卵巣癌総合診療制度機構(JOHBOC)学術総会   54KJPNデータを用いた日本人一般集団におけるBRCA1/2遺伝子の病原性バリアント頻度ならびに病原性解析について

    真里谷奨, 井戸川雅史, 櫻井晃洋, 他

     More details

  • 藤本征一郎賞(最優秀演題賞)

    2023.12   第25回北海道出生前診断研究会   胚培養液中 cell-free lncRNA 発現プロファイルを根拠とした無侵襲着床前胚染色体異数性検査アルゴリズムの構築に関する検討

    真里谷奨, 倉橋浩樹 他

     More details

  • 最優秀演題賞

    2023.10   第100回北海道産科婦人科学会・学術講演会   子宮内膜癌分子プロファイルのVirtual screeningシステム創出を目指した病理組織像のAI解析アルゴリズム構築について

    真里谷奨, 梅本美菜, 他

     More details

  • 優秀日本語演題賞

    2023.4   第75回日本産科婦人科学会学術講演会   深層学習を用いたHE染色からの 子宮内膜癌分子生物学的プロファイル推定の適否に関する検討

    梅本美菜, 真里谷奨 他

     More details

  • 優秀演題

    2022.11   第8回日本産科婦人科遺伝診療学会学術講演会   複雑なX染色体重複領域を伴う症例におけるロングリードシーケンサーを用いたPGT-Mセットアップについて

    真里谷奨, 倉橋浩樹 他

     More details

  • 高得点演題

    2022   第64回日本婦人科腫瘍学会学術講演会   Label Smoothingを併用した2 段階CNNによる子宮頸部細胞診断支援アルゴリズムについて

    梅本美菜, 真里谷奨 他

     More details

  • 優秀演題

    2020   第 61 回日本臨床細胞学会総会春期大会   Deep Learning(YOLO)を用いた子宮頸 部細胞診診断支援の有用性

    新開翔太, 真里谷奨 他

     More details

  • 学術奨励賞

    2020   第40回医療情報学連合大会   YOLOv3 を用いた子宮頚部細胞の自動分類手法の提案

    南部優太, 真里谷奨 他

     More details

▼display all

Research Projects

  • ロングリードシーケンサーによる新生児・周産期ゲノム解析プラットフォームの構築研究

    2025.4 - 2026.3

    公益財団法人 日母おぎゃー献金基金  研究費助成金 

      More details

    Authorship:Principal investigator 

    researchmap

  • 胚培養液中cell-freeRNAの解析による異数性胚細胞制御メカニズムの解明

    Grant number:24K12603  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    真里谷 奨

      More details

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    researchmap

  • 子宮内免疫環境ならびに細菌叢解析に基づく新規子宮内炎症性病態の確立

    2023.12 - 2025.12

    公益財団法人 今井精一記念財団  2023年度(第4回)研究助成金 

      More details

    Authorship:Principal investigator 

    researchmap

  • A study of computer aided diagnosis system of cervical cytology using deep learning.

    Grant number:23K08849  2023.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    researchmap

  • 深層学習を用いた婦人科細胞診断支援装置の社会実装へ向けた研究

    2022.4 - 2024.3

    公益財団法人高橋産業経済研究財団  研究助成金 

      More details

    Authorship:Principal investigator 

    researchmap

  • マルチモーダルイメージ解析による婦人科がん免疫プロファイルの解明

    2022.4 - 2023.3

    公益財団法人北海道科学技術総合振興センター  イノベーション創出研究支援事業(産学連携創出(スタートアップ研究)補助金) 

      More details

  • 北海道周産期・新生児WES・WGS検査解析プラットフォーム確立へ向けた至適実施体制構築に関する基盤的研究

    2022.4 - 2023.3

    公益財団法人 川野小児医学奨学財団  研究助成金 

      More details

    Authorship:Principal investigator 

    researchmap

  • 胚培養液を用いた非侵襲的着床前胚染色体異数体検査法

    2022.4 - 2023.3

    公益財団法人杉山記念財団  研究活動助成 

      More details

    Authorship:Principal investigator 

    researchmap

  • 婦人科がん幹細胞を標的とした新規免疫療法の確立

    Grant number:20K16363  2020.4 - 2024.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    真里谷 奨

      More details

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    免疫チェックポイント阻害剤による治療が一般化していく中で、婦人科がんにおいてもMSI-HighがんやTMB-Highがんに対するPembrolizumabが治療に広く用いられている。本治療はがん幹細胞のみならずがん全体を治療標的としたものであるが、現状がん標的治療の中では分子標的治療薬とならび最も奏功が期待できる治療法の一つである。我々は免疫チェックポイント阻害剤投与のサロゲートマーカーとして、現在新たに深層学習を用いたがん病理組織の形態学的評価を用いることができないかと考えている。深層学習アルゴリズム構築に際し学習教師データとして用いるのは、MMR関連遺伝子や抗原提示に関わる分子の他、ALDH1A1やCD133といったがん幹細胞様亜集団にて高陽性となるバイオマーカーの発現に関するパラメータである。現在予備検討として、自施設の臨床細胞検体ならびに病理検体の形態学的診断ならびに免疫チェックポイント阻害剤のサロゲートマーカーとなり得るバイオマーカー発現状況の推定において、深層学習を用いた判定アルゴリズムを用いる検討を行っている。高品質かつ多量の教師データの利用により、細胞形態から悪精度を高精度に判定可能であることを確認し、深層学習が婦人科がんの形態診断においてもブレークスルーとなり得ることを確認した。現在は同手法を応用する形で子宮がん(子宮内膜がん、子宮頸がん)病理組織像からの免疫制御ならびにがん幹細胞関連分子の発現および抑制状況を推定するアルゴリズムの構築を行なっている。

    researchmap

  • 深層学習を用いた婦人科細胞診診断支援システムの確立について

    2020.4 - 2021.3

    公益財団法人秋山記念生命科学振興財団  研究助成 

      More details

    Authorship:Principal investigator 

    researchmap

  • 深層学習を用いた婦人科細胞診診断支援システムの確立について

    2020.4 - 2021.3

    公益財団法人北海道科学技術総合振興センター  スタートアップ研究補助金 

      More details

    Authorship:Principal investigator 

    researchmap

  • 異常浸潤胎盤のがん類似形質に着目した新規診断バイオマーカーの確立

    2019.4 - 2021.3

    公益財団法人武田科学振興財団  ビジョナリーリサーチ助成(スタート) 

      More details

▼display all