Papers - MIO Kitagawa

Expression of Ku70 predicts results of radiotherapy in prostate cancer.

Tomokazu Hasegawa, Masanori Someya, Masakazu Hori, Yoshihisa Matsumoto, Kensei Nakata, Masanori Nojima, Mio Kitagawa, Takaaki Tsuchiya, Naoya Masumori, Tadashi Hasegawa, Koh-Ichi Sakata

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]   193 ( 1 ) 29 - 37  2017.01  [Refereed]  [International journal]

　View Summary

BACKGROUND AND PURPOSE: Therapeutic strategy for prostate cancer is decided according to T stage, Gleason score, and prostate-specific antigen (PSA) level. These clinical factors are not accurate enough to predict individual risk of local failure of prostate cancer after radiotherapy. Parameters involved with radiosensitivity are required to improve the predictive capability for local relapse. PATIENTS AND METHODS: We analyzed 58 patients with localized adenocarcinoma of the prostate between August 2007 and October 2010 treated with 76 Gy of intensity-modulated radiotherapy (IMRT) as a discovery cohort and 42 patients between March 2001 and May 2007 treated with three-dimensional conformal radiotherapy (3D-CRT) as a validation cohort. Immunohistochemical examination for proteins involved in nonhomologous end-joining was performed using biopsy specimens. RESULTS: Ku70 expression was not correlated with various clinical parameters, such as the Gleason score and D'amico risk classification, indicating that Ku70 expression was an independent prognostic factor. The predictive value for PSA relapse was markedly improved after the combination of Gleason score and Ku70 expression, as compared with Gleason score alone. In patients treated with radiotherapy and androgen deprivation therapy (ADT), no relapses were observed in patients with Gleason score ≤7 or low Ku70 expression. In contrast, patients with Gleason score ≥8 and high Ku70 expression had high PSA relapse rates. In the validation cohort, similar results were obtained. CONCLUSION: Treatment with 76 Gy and ADT can be effective for patients with Gleason score ≤7 or low Ku70 expression, but is not enough for patients with Gleason score ≥8 and high Ku70 expression and, thus, require other treatment approaches.

DOI PubMed

Intracavitary radiation therapy for patient with isolated vaginal stump recurrence/residual tumor of gynecologic malignancies after radical hysterectomy

K. Nakata, M. Someya, M. Hori, Y. Takada, M. Kitagawa, T. Hasegawa, T. Gochou, K. Sakata

Japanese Journal of Clinical Radiology ( Kanehara Shuppan Co. Ltd )  59 ( 10 ) 1372 - 1378  2014.10

　View Summary

This study was a retrospective analysis of 23 patients with vaginal stump recurrence/residual carcinoma after radical hysterectomy for gynecologic malignancies, who were treated by intracavitary radiotherapy at Sapporo Medical University Hospital between 1991 and 2012. Five years overall survival rates and local recurrence free survival rates were 61.3% and 75% in the group of recurrence, and both 100% in the group of residual As for morbidity, no patients received grade 3 or greater late toxicity except only 1 patient grade 3 vaginal mucosal necrosis. Intracavitary radiation therapy provides excellent local control of isolated vaginal stump recurrence/ residual tumor after radical hysterectomy.