研究者詳細 - 長岡　由修

論文 - 長岡　由修

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Acute osteomyelitis/septic pulmonary embolism associated with familial infections caused by PVL-positive ST6562 MRSA-IVa, a presumptive variant of USA300 clone.

Nao Harada, Atsuo Togashi, Meiji Soe Aung, Jun Kunizaki, Kazutaka Nogami, Yoshinobu Nagaoka, Akira Ishii, Ima Kosukegawa, Wakiko Aisaka, Satoshi Nakamura, Tomohiro Wakabayashi, Takeshi Tsugawa, Nobumichi Kobayashi

IJID regions 8 16 - 18 2023年09月 [国際誌]

Panton-Valentine leukocidin (PVL)-positive methicillin-resistant Staphylococcus aureus (MRSA) occasionally causes severe invasive infections. A 10-year-old immunocompetent boy in Hokkaido, the northern main island of Japan, was admitted with acute osteomyelitis of the right ilium, complicated by septic thrombophlebitis of the right common iliac vein and septic pulmonary embolism. As MRSA was isolated from blood and sputum samples of the patient, linezolid and vancomycin were initially used for treatment, and later clindamycin was added based on PCR-positive results for PVL genes. During his hospitalization, the patient was complicated by abscesses around the right ilium and septic arthritis of the right hip, which required surgical drainage. Prior to his admission, his youngest sister had developed a right breast abscess, and another sister and his mother developed contagious impetigo and hordeolum, respectively, during his hospitalization. These infections in the patient and his family members were caused by an identical PVL-positive MRSA strain belonging to ST6562, a single-locus variant of ST8. Due to the genetically close characteristics, this ST6562 MRSA was considered a genetic variant of the USA300 CA-MRSA clone (ST8-MRSA-IVa) predominating in the United States. The ST6562 MRSA-IVa is suggested to have occurred in Japan, associated with potential spread of the USA300 clone.

DOI PubMed

NPHS1遺伝子に複合ヘテロ接合体ミスセンス変異を同定したステロイド抵抗性ネフローゼ症候群の1例

長岡由修, 若林知宏, 矢吹郁美, 飯塚裕典, 稲澤奈津子, 木澤敏毅, 伊藤希美, 東舘義仁, 小川弥生, 石河慎也, 長野智那, 野津寛大, 飯島一誠, 川崎幸彦

日本小児腎臓病学会雑誌 ( (一社)日本小児腎臓病学会 ) 33 ( 1Suppl. ) 86 - 86 2020年12月

Poststreptococcal acute glomerulonephritis can be a risk factor for accelerating kidney dysfunction in Alport syndrome: a case experience.

Yoshinori Araki, Azusa Kawaguchi, Nana Sakakibara, Yoshinobu Nagaoka, Tomohiko Yamamura, Tomoko Horinouchi, China Nagano, Naoya Morisada, Kazumoto Iijima, Kandai Nozu

CEN case reports 9 ( 4 ) 418 - 422 2020年06月 [査読有り] [国内誌]

Alport syndrome (AS) is a progressive kidney disease. Male cases with X-linked AS (XLAS) are reported to develop end-stage kidney disease (ESKD) at the age of around 20-30 years. One risk factor for developing ESKD at a young age is a genotype of having truncating variants in the COL4A5 gene. However, to date, other such factors have remained unclear. Here, we describe a 15-year-old Japanese boy with XLAS who had a missense variant in the COL4A5 gene. He presented with gross hematuria, severe proteinuria, oliguria, systemic edema, body weight gain, and hypertension after pharyngitis. Blood examination showed kidney dysfunction, hypocomplementemia, and elevated antistreptolysin-O level. We diagnosed him with poststreptococcal acute glomerulonephritis (PSAGN) and he was stopped treatment by lisinopril, and received supportive treatment. However, he showed an unusual clinical course for PSAGN and, consequently, developed ESKD 15 months after the onset of PSAGN without recovery from the kidney dysfunction. This case showed that the onset of PSAGN can be a risk factor for AS patients to develop ESKD at a young age.

DOI PubMed

P450オキシドレダクターゼ(POR)異常症の1例

若林知宏, 長岡由修, 石井玲, 津川毅, 鎌崎穂高, 要藤裕孝, 川崎幸彦, 足立周平, 本庄紗帆, 寺田光次郎, 中村秀勝, 五十嵐リサ, 小林正樹

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 123 ( 11 ) 1721 - 1721 2019年11月

思春期早発症を契機に発見された頭蓋内胚細胞腫の1男児例

飯塚裕典, 石井玲, 長岡由修, 津川毅, 鎌崎穂高, 要藤裕孝, 竹林晃, 家里琴絵, 五十嵐敬太, 山本雅樹, 堀司, 秋山幸功, 母坪智行

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 123 ( 5 ) 937 - 937 2019年05月

二絨毛膜二羊膜双胎プルーンベリー症候群の女児例

住川拓哉, 親谷佳佑, 房川眞太郎, 石川淑, 浅沼秀臣, 萬谷和香子, 上原央久, 西中一幸, 縫明大, 石郷岡哲郎, 長岡由修

日本小児腎臓病学会雑誌 ( (一社)日本小児腎臓病学会 ) 32 ( 1 ) 58 - 58 2019年04月

吐血を契機に発見され、肝硬変を呈していた自己免疫性肝炎の14歳女児

長岡由修, 石井玲, 津川毅, 竹内孝子, 鎌崎穂高, 要藤裕孝, 杉田真太朗, 阿久津典之, 佐々木茂, 末岡秀文, 佐藤俊哉

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 122 ( 11 ) 1746 - 1746 2018年11月

血清における炎症反応と臨床症状に乖離を認めたCRMOの1例

木澤敏毅, 長岡由修, 石井玲, 津川毅, 鎌崎穂高, 要藤裕孝, 伊藤希美, 東舘義仁

日本小児リウマチ学会総会・学術集会プログラム・抄録集 ( (一社)日本小児リウマチ学会 ) 28回 88 - 88 2018年10月

新生児期にショックを呈した両側閉塞性巨大尿管の1例

荒井勇人, 横澤まさと, 高室基樹, 名和智裕, 太刀川公人, 西中一幸, 長岡由修

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 122 ( 7 ) 1244 - 1245 2018年07月

新生児期にショックを呈した両側閉塞性巨大尿管の一例

荒井勇人, 名和智裕, 高室基樹, 横澤正人, 長岡由修, 太刀川公人, 西中一幸

日本小児腎臓病学会雑誌 ( (一社)日本小児腎臓病学会 ) 31 ( 1 ) 71 - 71 2018年04月

中枢性尿崩症の発症から約1年後に胚細胞腫と診断された男児例

竹内孝子, 石井玲, 長岡由修, 津川毅, 山本雅樹, 堀司, 鎌崎穂高, 要藤裕孝, 堤裕幸, 秋山幸功, 山直也, 長谷川匡

日本内分泌学会雑誌 ( (一社)日本内分泌学会 ) 93 ( 3 ) 656 - 656 2017年12月

早期治療介入した色素失調症の新生児例

重冨浩子, 田中藤樹, 東梅ひろみ, 榊原菜々, 長岡由修, 荒木義則, 長尾雅悦, 肥田時征, 齋藤哲哉

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 121 ( 11 ) 1889 - 1890 2017年11月

びまん性皮質下白質病変を伴う脳症を合併した溶血性尿毒症症候群の1例

小笠原真志, 野上和剛, 西田剛士, 高山留美子, 長谷山圭司, 渡邊年秀, 長岡由修, 荒木義則, 長尾雅悦

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 120 ( 2 ) 359 - 359 2016年02月

Long-term morbidity of IgA nephropathy in children evaluated with newly proposed remission criteria in Japan.

Shoko Matsushita, Kenji Ishikura, Shojiro Okamoto, Yusuke Okuda, Yoshinobu Nagaoka, Ryoko Harada, Riku Hamada, Tomoyuki Sakai, Yuko Hamasaki, Hiroshi Hataya, Takashi Ando, Kentaro Ogata, Masataka Honda

Clinical and experimental nephrology 19 ( 6 ) 1149 - 56 2015年12月 [査読有り] [国内誌]

BACKGROUND: The long-term outcome of pediatric IgA nephropathy (IgAN) is unclear. Objective IgAN remission criteria were proposed by the Japanese Society of Nephrology in 2013. METHODS: Children with newly developed IgAN followed for >5 years were analyzed. They were divided into two groups based on histological findings at initial kidney biopsy: the focal mesangial proliferation group (Focal group) and diffuse mesangial proliferation group (Diffuse group). The primary outcome was the remission rate according to the newly proposed IgAN remission criteria. RESULTS: The patients comprised 53 children (31 boys; mean age at IgAN onset, 10.0 years). The Focal and Diffuse groups comprised 21 and 32 patients, respectively. No significant differences in patient characteristics were found between the groups except for steroid administration. The median follow-up period from onset was 9.9 years. Sixteen patients in the Diffuse group and 10 in the Focal group had not achieved remission at the last observation. Patient conditions 2 years after the initial treatment were almost identical to those at the last observation. Multivariate analysis revealed that proteinuria, particularly <0.5 g/g Cr at 2 years, was significantly associated with remission at the last observation regardless of proteinuria status at the start of treatment. CONCLUSIONS: Pediatric IgAN has a prolonged course that is longer than expected regardless of severity at diagnosis. Patient conditions 2 years after initial treatment predicted their conditions at the last observation. Although the final renal function of these patients is presently unclear, children with IgAN should be followed beyond adolescence and further into adulthood.

DOI PubMed

OAS(Oral Allergy Syndrome)により高度気道狭窄を呈した10歳男児の一例

堀大紀, 小笠原真志, 小杉陽祐, 長岡由修, 杉原暁美, 長谷山圭司, 高室基樹, 横澤正人

日本小児科学会雑誌 ( (公社)日本小児科学会 ) 119 ( 2 ) 350 - 350 2015年02月

Early and frequent development of ocular hypertension in children with nephrotic syndrome.

Emi Kawaguchi, Kenji Ishikura, Riku Hamada, Yoshinobu Nagaoka, Yoshihiko Morikawa, Tomoyuki Sakai, Yuko Hamasaki, Hiroshi Hataya, Eiichiro Noda, Masaru Miura, Takashi Ando, Masataka Honda

Pediatric nephrology (Berlin, Germany) 29 ( 11 ) 2165 - 71 2014年11月 [査読有り] [国際誌]

BACKGROUND: Prednisolone, the first-line treatment for children with nephrotic syndrome, causes severe side effects. One of these side effects is ocular hypertension, which can result in severe and permanent visual disturbance. However, the exact prevalence, severity and timing of development of ocular hypertension have yet to be fully explored in this pediatric patient group. METHODS: In this retrospective cohort study, children with nephrotic syndrome treated with prednisolone for their first episode were analyzed. Intraocular pressure was screened with an iCare® tonometer and confirmed with Goldmann applanation tonometry before the initiation of prednisolone treatment and at 1 and 4 weeks thereafter. RESULTS: A total of 26 children with nephrotic syndrome were included in this study, of whom eight (30.8 %) required treatment with eye drops for ocular hypertension. The median time interval between the diagnosis of ocular hypertension and start of treatment was 9 (range 5-31) days. At relapse of nephrotic syndrome, all children who had undergone treatment for ocular hypertension in their first episode again required treatment for ocular hypertension. CONCLUSIONS: Routine ophthalmologic examination should be conducted from the early phase after the start of prednisolone treatment. In addition, children with episodes of ocular hypertension may be at greater risk of its reappearance with relapse of the nephrotic syndrome.

DOI PubMed

Longitudinal analysis of VP7 gene of group A human rotavirus G2P[4] strains circulating in the pre-vaccine era in Sapporo, Japan from 1991 to 2011.

Masatoshi Tatsumi, Yoshinobu Nagaoka, Takeshi Tsugawa, Yuko Yoto, Tsukasa Hori, Hiroyuki Tsutsumi

Microbiology and immunology 58 ( 9 ) 540 - 4 2014年09月 [査読有り] [国際誌]

DOI PubMed

Characterization of the NSP4 gene of group A human rotavirus G1P[8] strains circulating in Sapporo, Japan from 1987 to 2000.

Masatoshi Tatsumi, Yoshinobu Nagaoka, Takeshi Tsugawa, Yuko Yoto, Tsukasa Hori, Hiroyuki Tsutsumi

Journal of medical virology 86 ( 2 ) 354 - 9 2014年02月 [査読有り] [国際誌]

The genetic diversity of the NSP4 gene of rotavirus G1P[8] strains obtained in Sapporo was analyzed, Japan from 1987 to 2000. Sixty-four strains, which were distributed across the whole study period, were included. All G1P[8] NSP4 genes detected in this study belonged to genotype E1, which divided into at least three lineages. The Sapporo rotavirus G1P[8] isolates were found in each lineage. The mean estimated substitution rate was 1.40 × 10(-3) nucleotide substitutions per site per year, which was comparable to that of the G1P[8] VP7 gene. Comparison of the deduced NSP4 amino acid sequences showed genetic diversity at the center of antigenic site II, but not in the enterotoxic domain. This report represents the first investigation of the genetic diversity and evolution of group A rotavirus NSP4 genes in Asia.

DOI PubMed

Severe posterior reversible encephalopathy syndrome resolved with craniectomy.

Yoshinobu Nagaoka, Kenji Ishikura, Riku Hamada, Tadashi Miyagawa, Tatsuo Kono, Tomoyuki Sakai, Yuko Hamasaki, Hiroshi Hataya, Masataka Honda

Pediatrics international : official journal of the Japan Pediatric Society 55 ( 5 ) 644 - 6 2013年10月 [査読有り] [国際誌]

Posterior reversible encephalopathy syndrome (PRES) has been thought to be a benign disease, but recently severe cases have been reported with increasing recognition. A 3-year-old girl with congenital nephrotic syndrome had rapidly progressed to coma. Computed tomography (CT) of the head showed striking swelling of the brainstem and transtentorial herniation. Emergency decompressive craniectomy was performed. Consecutively, blood pressure was optimally controlled. The patient gradually recovered to the previous state before onset of PRES. Rapid improvement of clinical symptoms and rapid resolution of abnormal findings on serial CT led to diagnosis of PRES. In severe PRES with unstable vital signs, surgical intervention should be considered as well as appropriate blood pressure management.

DOI PubMed

NPHS1遺伝子の複合ヘテロ接合体変異を認めた先天性ネフローゼ症候群の姉妹例

荒木義則, 平子陽子, 長岡由修, 長尾雅悦, 中西浩一, 吉川徳茂

日本小児腎臓病学会雑誌 ( (一社)日本小児腎臓病学会 ) 26 ( 1Suppl. ) 141 - 141 2013年05月

フィンランド型先天性ネフローゼ症候群の腎移植までの管理

濱崎祐子, 石倉健司, 原田涼子, 長岡由修, 池宮城雅子, 山田剛史, 濱田陸, 坂井智行, 幡谷浩史, 本田雅敬, 中西浩一, 吉川徳茂

日本小児腎臓病学会雑誌 ( (一社)日本小児腎臓病学会 ) 25 ( 1Suppl. ) 175 - 175 2012年05月

Phylogenetic and computational structural analysis of VP7 gene of group a human rotavirus G1P[8] strains obtained in Sapporo, Japan from 1987 to 2000.

Yoshinobu Nagaoka, Masatoshi Tatsumi, Takeshi Tsugawa, Yuko Yoto, Hiroyuki Tsutsumi

Journal of medical virology 84 ( 5 ) 832 - 8 2012年05月 [査読有り] [国際誌]

Many studies indicate that G1P[8] genotypes are the most prevalent rotavirus strains worldwide. Although two vaccines have been licensed and their value proven in many countries, continuous surveillance for genetic evolution of circulating rotavirus strains before and after the introduction of the vaccines is desirable. G and P typing were carried out on all field strains isolated during 1987-2000 in Sapporo, Japan. Phylogenetic analysis for the VP7 gene of rotavirus G1P[8] strains was performed. Amino acid substitutions were mapped on the predicted three-dimensional VP7 protein image. G1P[8] genotype predominated. One hundred thirteen strains with G1P[8] genotype were analyzed. Phylogenetic studies of the VP7 gene classified these strains into three lineages. The mean estimated substitution rate was 7.25 × 10(-4) nucleotide substitutions per site per year. One predominant lineage contained the mutant strains which had VP7 amino acid substitutions at residue 91 and 212 that is in the neutralization domains. They were estimated to locate in or near intersubunit boundary of VP7 trimer. It is suggested that the most prevalent G1P[8] lineage strains in Sapporo obtained some survival advantages by changing the neutralization domains of VP7.

DOI PubMed

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