研究者詳細 - 石貫　智裕

論文 - 石貫　智裕

分割表示 13 件中 1 - 13 件目／全件表示 >>

Utility of a Wearable Tracker to Assess Sleep Quality in Nurses and Their Spouses: A Prospective Cohort Study

Tomohiro Ishinuki, Erika Goda, Hiroomi Tatsumi, Goro Kutomi, Toshio Ohyanagi, Hirofumi Ohnishi, Yoshiki Masuda, Thomas T. Hui, Toru Mizuguchi

SAGE Open Nursing ( SAGE Publications ) 11 2025年01月 [国際誌]

DOI

Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis.

Motoi Uchino, Koji Tamura, Shinsuke Nomura, Seiichi Shinji, Keita Kouzu, Hiroji Shinkawa, Tomohiro Ishinuki, Toru Mizuguchi, Hiroki Ohge, Seiji Haji, Junzo Shimizu, Yasuhiko Mohri, Chizuru Yamashita, Yuichi Kitagawa, Katsunori Suzuki, Motomu Kobayash, Masahiro Kobayashi, Yuki Hanai, Hiroshi Nobuhara, Hiroki Imaoka, Masahiro Yoshida, Toshihiko Mayumi, Hiroki Ikeuchi

BMC surgery 25 ( 1 ) 38 - 38 2025年01月 [査読有り] [国際誌]

BACKGROUND: Surgical site infections (SSIs) can affect mortality, morbidity, and medical costs. Although it has recently been reported that washing with antiseptic/antibiotic solution can prevent SSI in clean surgery, the clinical impact in gastrointestinal surgery is still uncertain. Therefore, we performed a systematic review and meta-analysis to evaluate the efficacy of antiseptic/antibiotic solution during wound irrigation or peritoneal lavage in gastroenterological surgery. METHODS: The database search used PubMed, MEDLINE, and Cochrane Library. The following inclusion criteria were set for the systematic review. 1) Studies comparing with or without antiseptic/antibiotic irrigation/lavage during gastrointestinal surgery. 2) Studies that described surgical site infections and adverse events. 3) Studies conducted after 2000. RESULTS: A total of 8 randomized controlled studies (RCTs) and 3 observational studies were included in this meta-analysis. Three RCTs of wound irrigation with povidone iodine (PVI) solution revealed no significant difference between the PVI and control groups [RR 1.41, 95% CI (0.92 to 2.17): p = 0.69]. Three RCTs of peritoneal lavage with antibiotic solution showed no significant difference between the interventional group and control groups [RR 0.39, 95% CI (0.10 to 1.55): p = 0.18]. Regarding other antiseptic or antibiotic solutions, the number of studies and participants were too small for evaluation. CONCLUSION: Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution did not have enough efficacy for preventing SSI during gastroenterological surgery.

DOI PubMed

electronic Patient Reported Outcome(ePRO)システムを活用した消化器外科手術後の手術部位感染が医療費に与える影響に関する検討

石貫智裕, 加藤透, 合田恵理香, 進士誠一, 吉田寛, 渡邉学, 横尾英樹, 柴田英貴, 青木武士, 問山裕二, 西森英史, 秦史壯, 水口徹

日本外科感染症学会雑誌 ( (一社)日本外科感染症学会 ) 20 ( 5-6 ) 527 - 532 2024年09月

【背景】消化器外科領域における手術部位感染症(surgical site infection:以下,SSI)の発症率は高いが,その医療経済的な影響に関するエビデンスは不足している。本研究は医療費に対するSSI発症の影響をオンラインによる患者報告アウトカム電子システム(electronic Patient Reported Outcome:以下,ePRO)を活用して検証した。【方法】2020年10月～2022年8月までに肝がん,膵がんに対して施行した肝切除術症例19例,膵切除術症例18例を対象に,SSI非発症群とSSI発症群の医療費を,ePROを活用して比較した。【結果】SSIの発症率は肝切除術で16%,膵切除術で28%であった。SSI非発症群とSSI発症群における医療費は436±128千円と1,208±686千円で有意にSSI発症群が高かった(P<0.01)。【結論】肝切除または膵切除術を受けた患者においてSSI発症によって医療費が大きく増加することを,ePROを活用することにより検証できた。(著者抄録)

Association between skin suture devices and incidence of incisional surgical site infection after gastrointestinal surgery: A systematic review and network meta-analysis.

Keita Kouzu, Daijiro Kabata, Hiroji Shinkawa, Seiichi Shinji, Tomohiro Ishinuki, Koji Tamura, Motoi Uchino, Hiroki Ohge, Junzo Shimizu, Seiji Haji, Yasuhiko Mohri, Chizuru Yamashita, Yuichi Kitagawa, Katsunori Suzuki, Motomu Kobayashi, Masahiro Kobayashi, Yuki Hanai, Hiroshi Nobuhara, Hiroki Imaoka, Masahiro Yoshida, Toru Mizuguchi, Toshihiko Mayumi, Yuko Kitagawa

The Journal of hospital infection 2024年06月 [査読有り] [国際誌]

AIM: We aimed to compare which suture devices could reduce the incidence of incisional surgical site infections (SSIs) after gastrointestinal surgery using a systematic review and network meta-analysis. METHODS: The CENTRAL, PubMed, and ICHUSHI-Web databases were searched from January 1st, 2000, to December 31st, 2022, for randomised clinical trials (RCTs) comparing the incidence of incisional SSI after gastrointestinal surgery among patients treated with different surgical suture devices, including non-absorbable sutures, absorbable sutures, skin staplers, and tissue adhesives (last searched in August 23th 2023). The risk of bias was assessed using the criteria of the Cochrane Handbook for Systematic Reviews of Interventions. To estimate the pooled odds ratios (ORs) for each comparison, we employed a fixed-effect inverse-variance model based on the Mantel-Haenszel approach. This study was registered in PROSPERO and supported in part by the Japan Surgical Infection Society. RESULTS: A total of 18 RCTs with 5,496 patients were included in this study. The overall SSIs in absorbable sutures were significantly lower than the ones in skin staplers (OR: 0.77; 95% confidence intervals (CI): 0.63-0.95) and non-absorbable sutures (OR: 0.62; 95% CI: 0.39-0.99). On the other hand, SSIs in absorbable sutures were not statistically different from the SSIs in tissue adhesive. The highest P-score was 0.91 for absorbable sutures. A funnel plot for estimating the heterogeneity of the studies revealed that a publication bias would be minimal (Egger test, P = 0.271). CONCLUSION: This study showed that absorbable sutures reduced incisional SSIs in gastrointestinal surgical operations compared to any other suture devices.

DOI PubMed

Recent evidence for subcutaneous drains to prevent surgical site infections after abdominal surgery: A systematic review and meta-analysis

Tomohiro Ishinuki, Hiroji Shinkawa, Keita Kouzu, Seiichi Shinji, Erika Goda, Toshio Ohyanagi, Masahiro Kobayashi, Motomu Kobayashi, Katsunori Suzuki, Yuichi Kitagawa, Chizuru Yamashita, Yasuhiko Mohri, Junzo Shimizu, Motoi Uchino, Seiji Haji, Masahiro Yoshida, Hiroki Ohge, Toshihiko Mayumi, Toru Mizuguchi

World Journal of Gastrointestinal Surgery ( Baishideng Publishing Group Inc. ) 15 ( 12 ) 2879 - 2889 2023年12月 [査読有り] [招待有り] [国際誌]

担当区分：筆頭著者

BACKGROUND Surgical site infections (SSIs) increase mortality, hospital stays, additional medical treatment, and medical costs. Subcutaneous drains prevent SSIs in gynecological and breast surgeries; however, their clinical impact in abdominal surgery remains unclear. AIM To investigate whether subcutaneous drains were beneficial in abdominal surgery using a systematic review and meta-analysis. METHODS The database search used PubMed, MEDLINE, and the Cochrane Library. The following inclusion criteria were set for the systematic review: (1) Randomized controlled trial studies comparing SSIs after abdominal surgery with or without subcutaneous drains; and (2) Studies that described clinical outcomes, such as SSIs, seroma formation, the length of hospital stays, and mortality. RESULTS Eight studies were included in this meta-analysis. The rate of total SSIs was significantly lower in the drained group (54/771, 7.0%) than in the control group (89/759, 11.7%), particularly in gastrointestinal surgery. Furthermore, the rate of superficial SSIs was slightly lower in the drained group (31/517, 6.0%) than in the control group (49/521, 9.4%). No significant differences were observed in seroma formation between the groups. Hospital stays were shorter in the drained group than in the control group. CONCLUSION Subcutaneous drains after abdominal surgery prevented SSIs and reduced hospital stays but did not significantly affect seroma formation. The timing of drain removal needs to be reconsidered in future studies.

DOI

The effectiveness of fascial closure with antimicrobial-coated sutures in preventing incisional surgical site infections in gastrointestinal surgery: A systematic review and meta-analysis.

Keita Kouzu, Hironori Tsujimoto, Tomohiro Ishinuki, Seiichi Shinji, Hiroji Shinkawa, Koji Tamura, Motoi Uchino, Hiroki Ohge, Junzo Shimizu, Seiji Haji, Yasuhiko Mohri, Chizuru Yamashita, Yuichi Kitagawa, Katsunori Suzuki, Motomu Kobayashi, Masahiro Kobayashi, Yuki Hanai, Hiroshi Nobuhara, Hiroki Imaoka, Masahiro Yoshida, Toru Mizuguchi, Toshihiko Mayumi, Yuko Kitagawa

The Journal of hospital infection S0195-6701 ( 23 ) 00293-1 2023年09月 [査読有り] [国際誌]

INTRODUCTION: The aim of this study was to conduct a systematic review and meta-analysis of the efficacy of fascial closure using antimicrobial-sutures specifically for the prevention of surgical site infections (SSI) in gastrointestinal surgery, as part of the revision of the SSI prevention guidelines of the Japanese Society of Surgical Infectious Diseases (JSSI). METHODS: We searched the CENTRAL, PubMed, and ICHUSHI-Web in May 2023, and included randomized controlled trials (RCTs) comparing antimicrobial-coated and non-coated sutures for fascial closure in gastrointestinal surgery (PROSPERO No. CRD42023430377). Three authors independently screened the RCTs. We assessed the risk of bias and the GRADE criteria for the extracted data. The primary outcome was incisional SSI and the secondary outcomes were abdominal wall dehiscence and the length of postoperative hospital stay. This study was supported partially by the JSSI. RESULTS: A total of 10 RCTs and 5,396 patients were included. The use of antimicrobial-coated sutures significantly lowered the risk of incisional SSI compared to non-coated suture (risk ratio: 0.79, 95% confidence intervals: 0.64-0.98). In subgroup analyses, antimicrobial-coated sutures reduce the risk of SSI for open surgeries, and when monofilament sutures were used. Antimicrobial-coated sutures did not reduce the incidence of abdominal wall dehiscence and the length of hospital stay compared to non-coated sutures. The certainty of the evidence was rated as moderate according to the GRADE criteria, because of risk of bias. CONCLUSION: The use of antimicrobial-coated sutures for fascial closure in gastrointestinal surgery is associated with a significantly lower risk of SSI than non-coated sutures.

DOI PubMed

Clinical impact of rehabilitation and ICU diary on critically ill patients: A systematic review and meta‐analysis

Tomohiro Ishinuki, Ling Zhang, Keisuke Harada, Hiroomi Tatsumi, Nobuaki Kokubu, Yoshika Kuno, Kanon Kumasaka, Rina Koike, Toshio Ohyanagi, Hirofumi Ohnishi, Eichi Narimatsu, Yoshiki Masuda, Toru Mizuguchi

Nursing in Critical Care ( Wiley ) 28 554 - 565 2023年01月 [査読有り] [国際誌]

担当区分：筆頭著者

DOI

The structural relationships between quality of life and mental conditions in stoma patients

Narumi M, Nishimori H, Hasegawa M, Hazawa Y, Ishinuki T, Goda E, Hata F, Kihara C, Okita K, Ohyanagi T, Hui TT, Mizuguchi T

World Journal of Colorectal Surgery ( Medknow ) 12 ( 1 ) 1 - 1 2023年01月 [査読有り] [国際誌] [国際共著]

DOI

Current standard values of health utility scores for evaluating cost-effectiveness in liver disease: A meta-analysis.

Tomohiro Ishinuki, Shigenori Ota, Kohei Harada, Masaki Kawamoto, Makoto Meguro, Goro Kutomi, Hiroomi Tatsumi, Keisuke Harada, Koji Miyanishi, Toru Kato, Toshio Ohyanagi, Thomas T Hui, Toru Mizuguchi

World journal of gastroenterology 28 ( 31 ) 4442 - 4455 2022年08月 [査読有り] [国際誌] [国際共著]

担当区分：筆頭著者

BACKGROUND: Health utility assessments have been developed for various conditions, including chronic liver disease. Health utility scores are required for socio-economic evaluations, which can aid the distribution of national budgets. However, the standard health utility assessment scores for specific health conditions are largely unknown. AIM: To summarize the health utility scores, including the EuroQOL 5-dimensions 5-levels (EQ-5D-5L), EuroQol-visual analogue scale, short from-36 (SF-36), RAND-36, and Health Utilities Index (HUI)-Mark2/Mark3 scores, for the normal population and chronic liver disease patients. METHODS: A systematic literature search of PubMed and MEDLINE, including the Cochrane Library, was performed. Meta-analysis was performed using the RevMan software. Multiple means and standard deviations were combined using the StatsToDo online web program. RESULTS: The EQ-5D-5L and SF-36 can be used for health utility evaluations during antiviral therapy for hepatitis C. HUI-Mark2/Mark3 indicated that the health utility scores of hepatitis B patients are roughly 30% better than those of hepatitis C patients. CONCLUSION: The EQ-5D-5L is the most popular questionnaire for health utility assessments. Health assessments that allow free registration would be useful for evaluating health utility in patients with liver disease.

DOI PubMed

Maturation of robotic liver resection during the last decade: A systematic review and meta-analysis

Tomohiro Ishinuki, Shigenori Ota, Kohei Harada, Makoto Meguro, Masaki Kawamoto, Goro Kutomi, Hiroomi Tatsumi, Keisuke Harada, Koji Miyanishi, Ichiro Takemasa, Toshio Ohyanagi, Thomas T Hui, Toru Mizuguchi

World Journal of Meta-Analysis ( Baishideng Publishing Group Inc. ) 9 ( 5 ) 462 - 473 2021年10月 [査読有り] [国際誌] [国際共著]

担当区分：筆頭著者

DOI

Tomohiro Ishinuki, Shigenori Ota, Kohei Harada, Hiroomi Tatsumi, Keisuke Harada, Koji Miyanishi, Minoru Nagayama, Ichiro Takemasa, Toshio Ohyanagi, Thomas T Hui, Toru Mizuguchi

World Journal of Meta-Analysis ( Baishideng Publishing Group Inc. ) 9 ( 1 ) 88 - 100 2021年02月 [査読有り] [国際誌] [国際共著]

担当区分：筆頭著者

DOI

Nature of the liver volume depending on the gender and age assessing volumetry from a reconstruction of the computed tomography.

Kohei Harada, Tomohiro Ishinuki, Yoshiya Ohashi, Takeo Tanaka, Ayaka Chiba, Kanako Numasawa, Tatsuya Imai, Shun Hayasaka, Takahito Tsugiki, Koji Miyanishi, Minoru Nagayama, Ichiro Takemasa, Junji Kato, Toru Mizuguchi

PloS one 16 ( 12 ) e0261094 2021年 [査読有り] [国際誌]

Although the liver is a regenerating organ, excessive loss of liver volume (LV) can cause fatal liver failure. It is unclear whether LV is correlated with age; however, it is known that liver function decreases with age. In addition, the gender-related role of LV remains unclear. This study aimed to investigate the changes in LV by age and gender. Between January and December 2018, 374 consecutive patients who underwent abdominal multidetector computed tomography (MDCT) for any abdominal examinations were enrolled. LV was evaluated using MDCT. The relationship between the LV and body mass index (BMI), body surface area (BSA), age, and gender was investigated. The modified LV (mLV) was calculated by a formula measured LV × 1.5/BSA. LV correlated to BSA more than to BMI in both the males (R: 0.559 vs. 0.416) and females (R: 0.479 vs. 0.300) in our study. Age was negatively correlated to LV and BSA, and correlated to LV more than to BSA in males (R: 0.546 vs. 0.393) and females (R: 0.506 vs. 0.385). In addition, the absolute slope between age and LV in the males was higher than that in the females (14.1 vs. 10.2, respectively). Furthermore, the absolute slope of age and mLV in the males was slightly higher than in the females (9.1 vs. 7.3, respectively). In conclusion, LV in the normal liver is correlated to age rather than the one in the diseased liver. Liver volume in the males decreased more with age than LV in the females.

DOI PubMed

The Unique Mental Impacts of Breast-Conserving Surgery and Mastectomy According to a Multi-Centered Cross Sectional Survey Conducted in Japan

Yuri Hazawa, Goro Kutomi, Hiroaki Shima, Toshio Honma, Tosei Ohmura, Asaka Wada, Toshihiko Mikami, Miki Hotta, Momoka Narumi, Tomohiro Ishinuki, Yoshika Kuno, Makoto Meguro, Ichiro Takemasa, Minoru Okazaki, Hideji Masuoka, Kazuaki Asaishi, Toshio Ohyanagi, Thomas T. Hui, Toru Mizuguchi

Archives of Breast Cancer ( Archives of Breast Cancer ) 7 ( 3 ) 119 - 126 2020年08月 [査読有り] [国際誌] [国際共著]

Background: Improving health-related quality of life (HRQOL) has become a fundamental goal of breast cancer management. This study aimed to examine the differences between the QOL outcomes of breast-conserving surgery (BCS) and mastectomy. We also established structural equation models for BCS and mastectomy to elucidate their unique effects on QOL.Methods: Between July 2019 and November 2019, 254 patients, who were scheduled to visit one of four clinics, were recruited for this study. We evaluated HRQOL using various questionnaires, such as the BREAST-Q, EQ-5D-5L, and Hospital Anxiety and Depression Scale (HADS). The relationships among the examined clinical indicators were evaluated using structural equation modeling (SEM). Results: The QOL scores of the BCS group were better than those of the mastectomy group (0.85±0.129 vs. 0.81±0.12, P=0.020). Also, anxiety (2.94±2.95 vs. 3.81±3.08, P=0.025) and depression (2.55±2.77 vs. 3.74±3.19, P=0.002) were less severe in the BCS group than in the mastectomy group. Furthermore, the relationships among QOL status and mental health status were more complex in the BCS group than in the mastectomy group (Chi-square minimization p-value: 0.231 vs. 0.469, respectively). Also, depression directly affected QOL in the mastectomy group (R=-0.47), but not in the BCS group.Conclusions: There were differences in QOL and mental health between the BCS and mastectomy groups. SEM is useful for identifying such differences, which can be used to develop strategies for improving QOL.

DOI

　前のページ - 次のページ　

<石貫 智裕>

論文 - 石貫 智裕

<石貫　智裕>

論文 - 石貫　智裕