Organization
School of Medicine Department of Hematology Lecturer
Title
Lecturer
External link
HORIGUCHI Hiroto
Education
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Sapporo Medical University Graduate School of Medicine
2011.4 - 2015.3
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Sapporo Medical University
2000.4 - 2006.3
Country： Japan
Research History
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Sapporo Medical University Department of Hematology Lecturer
2025.4
Country：Japan
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Sapporo Medical University Department of Hematology Assistant Professor
2023.4 - 2025.3
Country：Japan
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Sapporo Medical University Department of Hematology
2019.4 - 2023.3
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Boston Children’s Hospital Division of Hematology/Oncology Research fellow
2016.7 - 2019.3
Country：United States
Papers
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Emergence and continuous clonal evolution of a<i> JAK2</i><i> exon</i><i> 12</i>-mutated myeloid clone after treatment for<i> de</i><i> novo</i> acute myeloid leukemia
Akari Goto, Satoshi Iyama, Masahiro Yoshida, Ayumi Tatekoshi, Hiroto Horiguchi, Masayoshi Kobune
LEUKEMIA RESEARCH 163 2026.4
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Warm Autoimmune Hemolytic Anemia Associated with Pancreatic Adenocarcinoma Showing Ectopic Expression of Band 3 Protein: A Case Report
Akari Goto, Makoto Yoshida, Ryosei Murai, Hiroto Horiguchi, Satoshi Iyama, Kazuma Ishikawa, Satoshi Takahashi, Kohichi Takada, Masayoshi Kobune
INTERNAL MEDICINE 2026.2
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Disruption of intestinal homeostasis reflected by DAO and microbiota alterations in gvhd post-HSCT.
Saori Shimoyama-Ibuki, Satoshi Iyama, Shotaro Shirato, Ken Sato, Masahiro Yoshida, Akari Goto, Hiroto Horiguchi, Masayoshi Kobune
BLOOD 146 2457 - 2458 2025.11
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Thrombotic risk with thrombopoietin receptor agonists in immune thrombocytopenia: Real-world evidence from a multicenter Japanese study
Masahiro Yoshida, Satoshi Iyama, Hiroto Horiguchi, Akari Goto, Makoto Ibata, Tetsuyuki Igarashi, Takeshi Kondo, Yasutaka Kakinoki, Yoshihito Haseyama, Hajime Sakai, Takahiro Nagashima, Shuichi Ota, Junki Inamura, Satoshi Yamamoto, Kentaro Wakasa, Tomoyuki Endo, Masaki Yamamoto, Yuichi Konuma, Shuichiro Takahashi, Naofumi Yamauchi, Katsuya Fujimoto, Masayoshi Kobune
BLOOD 146 2025.11
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Neuropeptide TIP39 induces autophagy in PTH2 receptor-positive myeloid neoplasms
Kento Ono, Hiroto Horiguchi, Satoshi Iyama, Ken Sato, Saori Ibuki-Shimoyama, Shotaro Shirato, Yusuke Sugama, Akari Goto, Masayoshi Kobune
INTERNATIONAL JOURNAL OF HEMATOLOGY 122 ( 3 ) 400 - 412 2025.9
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Prognostic impact of <i>TET2</i> mutations in patients with acute myeloid leukemia: HM-SCREEN-Japan 01 and 02 study
Satoshi Iyama, Sunggi Chi, Masashi Idogawa, Takayuki Ikezoe, Kentaro Fukushima, Yoshikazu Utsu, Junya Kanda, Goichi Yoshimoto, Takahiro Kobayashi, Naoko Hosono, Takahiro Yamauchi, Takeshi Kondo, Yukinori Nakamura, Kensuke Kojima, Chikashi Yoshida, Akihiko Gotoh, Kazuhito Yamamoto, Junya Kuroda, Kenji Ishitsuka, Emiko Sakaida, Hiroto Horiguchi, Kohichi Takada, Hirofumi Ohnishi, Masayoshi Kobune, Yosuke Minami
ANNALS OF HEMATOLOGY 104 ( 1 ) 275 - 284 2025.1
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Reduced FDG Uptake in the Brain on Baseline 18FDG PET/CT Predicts Worse Prognosis of Newly Diagnosed Intravascular Large B-Cell Lymphoma and Advanced-Stage Diffuse Large B-Cell Lymphoma
Hajime Senjo, Shinpei Harada, Koh Izumiyama, Hideki Goto, Shiro Watanabe, Keito Suto, Masayo Yamamoto, Kazuya Sato, Yasutaka Kakinoki, Tomoyuki Saga, Akio Shigematsu, Hiroto Horiguchi, Mutsumi Takahata, Reiki Ogasawara, Satoshi Yamamoto, Keisuke Yamaguchi, Kentaro Wakasa, Tetsuyuki Igarashi, Yoshihito Haseyama, Shinichi Ito, Katsuya Fujimoto, Junichi Hashiguchi, Junichi Sugita, Masao Nakagawa, Kenji Hirata, Takuto Miyagishima, Daigo Hashimoto, Takanori Teshima
BLOOD 144 3096 - 3097 2024.11
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Novel method for assessing sinusoidal obstruction syndrome using four-dimensional computed tomography
Saori Shimoyama-Ibuki, Satoshi Iyama, Yoshiya Ohashi, Kento Ono, Yusuke Sugama, Chisa Fujita, Akari Goto, Hiroto Horiguchi, Akihito Fujimi, Takeo Tanaka, Kohichi Takada, Koh-Ichi Sakata, Masayoshi Kobune
EJHAEM 5 ( 5 ) 1038 - 1042 2024.10
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Successful Pregnancy and Fetal Outcomes Following Brentuximab Vedotin for Early Relapsed Classic Hodgkin Lymphoma After Autologous Stem Cell Transplant
Akari Goto, Chisa Fujita, Hiroto Horiguchi, Satoshi Iyama, Masayoshi Kobune
CUREUS JOURNAL OF MEDICAL SCIENCE 16 ( 3 ) 2024.3
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Adherence of denosumab treatment for low bone mineral density in Japanese people living with HIV: a retrospective observational study
Yusuke Kunimoto, Ryosuke Matamura, Hiroshi Ikeda, Hiroto Horiguchi, Satoshi Fujii, Masayoshi Kobune, Masahide Fukudo, Takaki Toda
JOURNAL OF PHARMACEUTICAL HEALTH CARE AND SCIENCES 9 ( 1 ) 2023.12
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Baseline 18f-Fluorodeoxyglucose PET/CT Radiomics Predicts Outcome in Newly Diagnosed Intravascular Large B-Cell Lymphoma
Shinpei Harada, Hideki Goto, Hajime Senjo, Keito Suto, Shiro Watanabe, Koh Izumiyama, Masayo Yamamoto, Kazuya Sato, Yasutaka Kakinoki, Tomoyuki Saga, Akio Shigematsu, Hiroto Horiguchi, Mutsumi Takahata, Reiki Ogasawara, Satoshi Yamamoto, Keisuke Yamaguchi, Kentaro Wakasa, Tetsuyuki Igarashi, Yoshihito Haseyama, Shinichi Ito, Katsuya Fujimoto, Junichi Hashiguchi, Masao Nakagawa, Daigo Hashimoto, Takanori Teshima
BLOOD 142 2023.11
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Addition of High-Dose Methotrexate to Initial Chemotherapy Improved Treatment Outcome of Patients with Newly Diagnosed Intravascular Large B-Cell Lymphoma: A Multicenter, Retrospective Study
Shinpei Harada, Hideki Goto, Hajime Senjo, Keito Suto, Koh Izumiyama, Masayo Yamamoto, Kazuya Sato, Yasutaka Kakinoki, Tomoyuki Saga, Akio Shigematsu, Hiroto Horiguchi, Mutsumi Takahata, Reiki Ogasawara, Satoshi Yamamoto, Keisuke Yamaguchi, Kentaro Wakasa, Tetsuyuki Igarashi, Yoshihito Haseyama, Shinichi Ito, Katsuya Fujimoto, Junichi Hashiguchi, Masao Nakagawa, Daigo Hashimoto, Takanori Teshima
BLOOD 142 2023.11
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A Practice-Oriented Genome Profiling Study with the Novel Halo-Shape Annealing and Defer-Ligation Enrichment (HANDLE) System : HM-Screen-JAPAN02
Hironori Arai, SungGi Chi, Yoshikazu Utsu, Shinichi Masuda, Nobuyuki Aotsuka, Tomoaki Ueda, Kentaro Fukushima, Daisuke Ikeda, Naoko Hosono, Takahiro Yamauchi, Goichi Yoshimoto, Hiroto Horiguchi, Satoshi Iyama, Junya Kanda, Seiichiro Katagiri, Akihiko Gotoh, Daisuke Koyama, Takayuki Ikezoe, Takeshi Kondo, Yukinori Nakamura, Fumiya Ogasawara, Suguru Fukuhara, Koji Izutsu, Nobuhiko Yamauchi, Junichiro Yuda, Yosuke Minami
BLOOD 140 10722 - 10724 2022.11
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Incidentally Detected Complex Karyotypic Abnormalities in the Bone Marrow Provide a Clue to Diagnosing Intravascular Large B-Cell Lymphoma
Shinpei Harada, Hideki Goto, Hajime Senjo, Keito Suto, Koh Izumiyama, Masayo Yamamoto, Kazuya Sato, Yasutaka Kakinoki, Tomoyuki Saga, Akio Shigematsu, Hiroto Horiguchi, Mutsumi Takahata, Reiki Ogasawara, Satoshi Yamamoto, Keisuke Yamaguchi, Kentaro Wakasa, Tetsuyuki Igarashi, Yoshihito Haseyama, Shinichi Ito, Katsuya Fujimoto, Junichi Hashiguchi, Masao Nakagawa, Takanori Teshima
BLOOD 140 2022.11
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Elevated FDG Uptake in the Lung Is a Characteristic Finding of Intravascular Large B-Cell Lymphoma
Shinpei Harada, Hideki Goto, Hajime Senjo, Keito Suto, Shiro Watanabe, Yuko Uchiyama, Koh Izumiyama, Masayo Yamamoto, Kazuya Sato, Yasutaka Kakinoki, Tomoyuki Saga, Akio Shigematsu, Hiroto Horiguchi, Mutsumi Takahata, Reiki Ogasawara, Satoshi Yamamoto, Keisuke Yamaguchi, Kentaro Wakasa, Tetsuyuki Igarashi, Yoshihito Haseyama, Shinichi Ito, Katsuya Fujimoto, Junichi Hashiguchi, Masao Nakagawa, Takanori Teshima
BLOOD 140 6713 - 6714 2022.11
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Genomic Analysis of <i>NPM1</i> Mutation and <i>KMT2A</i>(<i>MLL</i>)-Rearrangement/Amplification in Japanese Patients with Acute Myeloid Leukemia: Hematologic Malignancies (HM)-Screen-Japan 01
Sung Gi Chi, Kentaro Fukushima, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Motoki Eguchi, Takanobu Morishita, Reiki Ogasawara, Takeshi Kondo, Masamitsu Yanada, Kazuhito Yamamoto, Tsutomu Kobayashi, Junya Kuroda, Yoshimasa Kamoda, Kensuke Usuki, Yoshikazu Utsu, Nobuyuki Aotsuka, Makoto Yoshimitsu, Kenji Ishitsuka, Yasuyuki Nagata, Takaaki Ono, Naohito Fujishima, Naoto Takahashi, Hiroto Horiguchi, Satoshi Iyama, Makoto Nakamura, Kensuke Kojima, Kaoru Yamamoto, Yukinori Nakamura, Suguru Fukuhara, Koji Izutsu, Nobuhiko Yamauchi, Junichiro Yuda, Yosuke Minami
BLOOD 138 2021.11
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Possible clinical outcomes using early enteral nutrition in individuals with allogeneic hematopoietic stem cell transplantation: A single-center retrospective study
Satoshi Iyama, Hiroomi Tatsumi, Tsukasa Shiraishi, Masahiro Yoshida, Ayumi Tatekoshi, Akihito Endo, Taichiro Ishige, Yuh Shiwa, Soushi Ibata, Akari Goto, Kana Nagashima, Hiroto Horiguchi, Chisa Fujita, Hiroshi Ikeda, Kohichi Takada, Takayuki Nobuoka, Yusuke Kamihara, Shohei Kikuchi, Tsutomu Sato, Hirofumi Ohnishi, Shin-ichi Yokota, Masayoshi Kobune
NUTRITION 83 2021.3
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Genetic Features of AML with MLL-Rearrangement and NPM1 Mutation: An Interim-Analysis of HM-Screen-Japan 01
SungGi Chi, Naoko Hosono, Takahiro Yamauchi, Kentaro Fukushima, Hirohiko Shibayama, Seiichiro Katagiri, Akihiko Gotoh, Motohito Okabe, Takanobu Morishita, Masamitsu Yanada, Kazuhito Yamamoto, Naohito Fujishima, Naoto Takahashi, Reiki Ogasawara, Takeshi Kondo, Yoshikazu Utsu, Nobuyuki Aotsuka, Yoshimasa Kamoda, Kensuke Usuki, Kanenari Takemura, Yasuyuki Nagata, Takaaki Ono, Tsutomu Kobayashi, Junya Kuroda, Hiroto Horiguchi, Satoshi Iyama, Suguru Fukuhara, Koji Izutsu, Makoto Nakamura, Kazuto Togitani, Kensuke Kojima, Kaoru Yamamoto, Yukinori Nakamura, Makoto Yoshimitsu, Kenji Ishitsuka, Kenichi Miyamoto, Yosuke Minami
BLOOD 136 2020.11
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CD34+Positive Myelodysplastic Cells with Ring Sideroblasts or SF3B1 Mutation Produce High Erythroferrone and GDF15
Hiroto Horiguchi, Masayoshi Kobune, Kento Ono, Saori Shimoyama, Chisa Fujita, Akari Goto, Hiroshi Ikeda, Satoshi Iyama
BLOOD 136 2020.11
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Genomic Analysis of <i>FLT3</i> Mutations in a Comprehensive NGS Multicenter Study of AML: HM-Screen-Japan 01
Kentaro Fukushima, SungGi Chi, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Takanobu Morishita, Masamitsu Yanada, Kazuhito Yamamoto, Naohito Fujishima, Naoto Takahashi, Reiki Ogasawara, Takeshi Kondo, Yoshikazu Utsu, Nobuyuki Aotsuka, Kensuke Usuki, Takaaki Ono, Tsutomu Kobayashi, Junya Kuroda, Hiroto Horiguchi, Satoshi Iyama, Suguru Fukuhara, Koji Izutsu, Makoto Nakamura, Kensuke Kojima, Kenichi Miyamoto, Yosuke Minami
BLOOD 136 2020.11
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Interim Analysis of Hematologic Malignancies (HM)-Screen-Japan 01: A Mutation Profiling Multicenter Study of Patients with AML
Kenichi Miyamoto, Kentaro Fukushima, SungGi Chi, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Seiichiro Katagiri, Akihiko Gotoh, Takanobu Morishita, Masamitsu Yanada, Kazuhito Yamamoto, Naohito Fujishima, Naoto Takahashi, Reiki Ogasawara, Takeshi Kondo, Yoshikazu Utsu, Nobuyuki Aotsuka, Kensuke Usuki, Takaaki Ono, Tsutomu Kobayashi, Junya Kuroda, Hiroto Horiguchi, Satoshi Iyama, Suguru Fukuhara, Koji Izutsu, Makoto Nakamura, Kensuke Kojima, Yosuke Minami
BLOOD 136 2020.11
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Successful brentuximab vedotin monotherapy against late relapse of classical Hodgkin lymphoma 6 years after first remission
Kana Nagashima, Shohei Kikuchi, Satoshi Iyama, Chisa Fujita, Akari Goto, Hiroto Horiguchi, Masayoshi Kobune
CLINICAL CASE REPORTS 8 ( 3 ) 466 - 468 2020.3
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EPO-R plus myelodysplastic cells with ring sideroblasts produce high erythroferrone levels to reduce hepcidin expression in hepatic cells
Shogo Miura, Masayoshi Kobune, Hiroto Horiguchi, Shohei Kikuchi, Satoshi Iyama, Kazuyuki Murase, Akari Goto, Hiroshi Ikeda, Kohichi Takada, Koji Miyanishi, Junji Kato
BLOOD CELLS MOLECULES AND DISEASES 78 1 - 8 2019.9
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miR-7977 inhibits the Hippo-YAP signaling pathway in bone marrow mesenchymal stromal cells
Masahiro Yoshida, Hiroto Horiguchi, Shohei Kikuchi, Satoshi Iyama, Hiroshi Ikeda, Akari Goto, Yutaka Kawano, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Junji Kato, Masayoshi Kobune
PLOS ONE 14 ( 3 ) 2019.3
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Deletion of Murine <i>Rhoh</i> induces More Aggressive Diffuse Large B Cell Lymphoma (DLBCL) Via Interaction with Kaiso and Regulation of BCL-6 Expression
Hiroto Horiguchi, Marioara Felicia Ciuculescu, Anja Troeger, Haiming Xu, Christian Brendel, David A. Williams
BLOOD 132 2018.11
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Extravesicular Mir-7977 Released from Leukemic Cells Inhibites the PCBP1-Mediated mRNA Stabilization and Hippo-YAP Signaling Pathway in Bone Marrow Mesenchymal Stromal Cells
Masahiro Yoshida, Satoshi Iyama, Hiroto Horiguchi, Akari Goto, Shohei Kikuchi, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Hiroshi Ikeda, Masahiro Maeda, Junji Kato, Masayoshi Kobune
BLOOD 132 2018.11
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Deletion of <i>Rhoh</i> Accelerates Development of Diffuse Large B Cell Lymphoma in <i>Bcl-6</i> Transgenic Mouse Model
Hiroto Horiguchi, Marioara Felicia Ciuculescu, Christian Brendel, David A. Williams
BLOOD 130 2017.12
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Extracellular Vesicle microRNAs from Acute Myeloid Leukemia Are Involved in the Regulation of Adherence Junction in Bone Marrow Microenvironment.
Masahiro Yoshida, Masayoshi Kobune, Shogo Miura, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato
BLOOD 128 ( 22 ) 2016.12
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CD34/EPO-R Double Positive MDS Cells Produce Erythroferrone in Response to Erythropoietin
Shogo Miura, Masayoshi Kobune, Soushi Ibata, Masahiro Yoshida, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Wataru Jomen, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato
BLOOD 128 ( 22 ) 2016.12
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A phase II trial of small-dose bortezomib, lenalidomide and dexamethasone (sVRD) as consolidation/maintenance therapy in patients with multiple myeloma
Soushi Ibata, Tsutomu Sato, Hiroyuki Kuroda, Yasuhiro Nagamachi, Satoshi Iyama, Akihito Fujimi, Yusuke Kamihara, Yuichi Konuma, Masahiro Yoshida, Ayumi Tatekoshi, Akari Hashimoto, Hiroto Horiguchi, Kaoru Ono, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Masayoshi Kobune, Yasuo Hirayama, Junji Kato
CANCER CHEMOTHERAPY AND PHARMACOLOGY 78 ( 5 ) 1041 - 1049 2016.11
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Effect of clarithromycin add-on therapy for patients with lenalidomid-resistant multiple myeloma
Shogo Miura, Hiroyuki Kuroda, Michiko Yamada, Ken Sato, Hiroto Horiguchi, Takanori Shibata, Naoki Uemura, Tomoyuki Abe, Shigeyuki Fujii, Masahiro Maeda, Junji Kato
ANNALS OF ONCOLOGY 27 2016.7
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Significance of upper and lower gastrointestinal endoscopy during small intestinal screening in non-Hodgkin's lymphoma
Ken Sato, Hiroyuki Kuroda, Shogo Miura, Hiroto Horiguchi, Takanori Shibata, Naoki Uemura, Tomoyuki Abe, Shigeyuki Fujii, Masahiro Maeda, Junji Kato
ANNALS OF ONCOLOGY 27 2016.7
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Isoform D of vascular endothelial growth factor in systemic capillary leak syndrome: a case report. International journal
Soushi Ibata, Tsutomu Sato, Kohichi Takada, Ayumi Tatekoshi, Akari Hashimoto, Yusuke Kamihara, Wataru Jomen, Hiroto Horiguchi, Kaoru Ono, Kazuyuki Murase, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato
Journal of medical case reports 10 125 - 125 2016.5
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Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms
Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Masahiro Yoshida, Masaki Murata, Kazuyuki Murase, Satoshi Iyama, Kohichi Takada, Tsutomu Sato, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yutaka Kawano, Koji Miyanishi, Norimasa Sawada, Junji Kato
HAEMATOLOGICA 101 ( 4 ) 437 - 447 2016.4
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Narrow-Band Ultraviolet B Phototherapy Ameliorates Acute Graft-Versus-Host Disease of the Intestine by Expansion of Regulatory T Cells
Akari Hashimoto, Tsutomu Sato, Satoshi Iyama, Masahiro Yoshida, Soushi Ibata, Ayumi Tatekoshi, Yusuke Kamihara, Hiroto Horiguchi, Kazuyuki Murase, Yutaka Kawano, Kohichi Takada, Koji Miyanishi, Masayoshi Kobune, Shingo Ichimiya, Junji Kato
PLOS ONE 11 ( 3 ) 2016.3
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Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial
Yasuo Hirayama, Kunihiko Ishitani, Yasushi Sato, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Hiroyuki Kuroda, Yasuhiro Nagamachi, Yuichi Konuma, Akihito Fujimi, Tamotsu Sagawa, Kaoru Ono, Hiroto Horiguchi, Takeshi Terui, Kazuhiko Koike, Toshiro Kusakabe, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 20 ( 5 ) 866 - 871 2015.10
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Exosomes Derived from AML/MDS Cells Is Involved in Stromal Dysfunction and Bone Marrow Failure
Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Wataru Jomen, Kazuyuki Murase, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Yusuke Kamihara, Koji Miyanishi, Yasushi Sato, Tsuyoshi Hayashi, Rishu Takimoto, Junji Kato
BLOOD 124 ( 21 ) 2014.12
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A role for peripherally inserted central venous catheters in the prevention of catheter-related blood stream infections in patients with hematological malignancies
Toshiro Sakai, Kyuhei Kohda, Yuichi Konuma, Yasuko Hiraoka, Yukari Ichikawa, Kaoru Ono, Hiroto Horiguchi, Ayumi Tatekoshi, Kouichi Takada, Satoshi Iyama, Junji Kato
INTERNATIONAL JOURNAL OF HEMATOLOGY 100 ( 6 ) 592 - 598 2014.12
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[Markers of bone metabolism in multiple myeloma patients switched from zoledronic acid to denosumab].
Ayumi Tatekoshi, Tsutomu Sato, Soushi Ibata, Akari Hashimoto, Yusuke Kamihara, Hiroto Horiguchi, Kaoru Ono, Kohichi Takada, Satoshi Iyama, Rishu Takimoto, Masayoshi Kobune, Junji Kato
[Rinsho ketsueki] The Japanese journal of clinical hematology 55 ( 11 ) 2271 - 6 2014.11
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RADIATION-INDUCED LEIOMYOSARCOMA IN PROSTATE AFTER BRACHYTHERAPY FOR PROSTATIC ADENOCARCINOMA
Hiroto Horiguchi, Kohichi Takada, Rishu Takimoto, Satoshi Iyama, Tsutomu Sato, Yasuo Hirayama, Toshifumi Hoki, Naoya Masumori, Tadashi Hasegawa, Junji Kato
ANNALS OF ONCOLOGY 25 2014.10
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EFFECT OF DULOXETINE ON PAINFUL CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY
Yasuo Hirayama, Takeshi Terui, Toshiro Kusakabe, Hiroto Horiguchi, Kaoru Ono, Kazuhiko Koike, Junji Kato, Kunihiko Ishitani
ANNALS OF ONCOLOGY 25 2014.10
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[Effective treatment of metastatic rhabdomyosarcoma with pazopanib].
Akari Hashimoto, Kohichi Takada, Rishu Takimoto, Hiroto Horiguchi, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Kaoru Ono, Ayumi Tatekoshi, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune, Yasuo Hirayama, Hiroshi Kitamura, Katsuya Nakanishi, Naoya Masumori, Tadashi Hasegawa, Junji Kato
Gan to kagaku ryoho. Cancer & chemotherapy 41 ( 8 ) 1041 - 4 2014.8
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Clinical utility of capsule endoscopy with flexible spectral imaging color enhancement for diagnosis of small bowel lesions
Yasushi Sato, Tamotsu Sagawa, Masahiro Hirakawa, Hiroyuki Ohnuma, Takahiro Osuga, Yutaka Okagawa, Fumito Tamura, Hiroto Horiguchi, Kohichi Takada, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Rishu Takimoto, Masayoshi Kobune, Junji Kato
ENDOSCOPY INTERNATIONAL OPEN 2 ( 2 ) E80 - E87 2014.6
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Narrowband ultraviolet B phototherapy ameliorates acute graft-versus-host disease by a mechanism involving in vivo expansion of CD4+CD25+Foxp3+regulatory T cells
Satoshi Iyama, Kazuyuki Murase, Tsutomu Sato, Akari Hashimoto, Ayumi Tatekoshi, Hiroto Horiguchi, Yusuke Kamihara, Kaoru Ono, Shohei Kikuchi, Kohichi Takada, Yutaka Kawano, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Satoru Mori, Junji Kato, Toshiharu Yamashita, Junji Kato
INTERNATIONAL JOURNAL OF HEMATOLOGY 99 ( 4 ) 471 - 476 2014.4
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Combination Chemotherapy of Azacitidine and Cetuximab for Therapy-Related Acute Myeloid Leukemia following Oxaliplatin for Metastatic Colorectal Cancer
Akari Hashimoto, Kohichi Takada, Hiroto Horiguchi, Tsutomu Sato, Satoshi Iyama, Kazuyuki Murase, Yusuke Kamihara, Kaoru Ono, Ayumi Tatekoshi, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Tomohisa Furuhata, Masayoshi Kobune, Rishu Takimoto, Koichi Hirata, Junji Kato
CASE REPORTS IN ONCOLOGY 7 ( 2 ) 316 - 322 2014
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Radiation-Induced Leiomyosarcoma of the Prostate after Brachytherapy for Prostatic Adenocarcinoma
Hiroto Horiguchi, Kohichi Takada, Yusuke Kamihara, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Ko Kobayashib, Yasuo Hirayama, Naoya Masumori, Tadashi Hasegawa, Junji Kato
CASE REPORTS IN ONCOLOGY 7 ( 2 ) 565 - 570 2014
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Efficacy of Enteral Supplementation Enriched with Glutamine, Fiber, and Oligosaccharide on Mucosal Injury following Hematopoietic Stem Cell Transplantation
Satoshi Iyama, Tsutomu Sato, Hiroomi Tatsumi, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Hiroto Horiguchi, Soushi Ibata, Kaoru Ono, Kazuyuki Murase, Kohichi Takada, Yasushi Sato, Tsuyoshi Hayashi, Koji Miyanishi, Emi Akizuki, Takayuki Nobuoka, Toru Mizugichi, Rishu Takimoto, Masayoshi Kobune, Koichi Hirata, Junji Kato
CASE REPORTS IN ONCOLOGY 7 ( 3 ) 692 - 699 2014
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Myelodysplastic Syndrome-Derived Stromal Cells Support Leukemia-Initiating Cells and Contradirectly Eliminate Normal CD34+Clonogenic Cells
Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Kaoru Ono, Yusuke Kamihara, Akari Hashimoto, Ayumi Tatekoshi, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato
BLOOD 122 ( 21 ) 2013.11
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Iron Chelation Therapy Could Rapidly Reduce Oxidative DNA Damage In CD34+Hematopoietic Cells Before Decrease Of Serum Ferritin Level
Masayoshi Kobune, Shohei Kikuchi, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Kaoru Ono, Hiroto Horiguchi, Yusuke Kamihara, Akari Hashimoto, Ayumi Tatekoshi, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato
BLOOD 122 ( 21 ) 2013.11
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[Successful treatment with rituximab in a patient with refractory mixed-type autoimmune hemolytic anemia].
Kaoru Ono, Tsutomu Sato, Satoshi Iyama, Ayumi Tatekoshi, Akari Hashimoto, Yusuke Kamihara, Hiroto Horiguchi, Shohei Kikuchi, Kohichi Takada, Tsuyoshi Hayashi, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato
[Rinsho ketsueki] The Japanese journal of clinical hematology 54 ( 11 ) 2053 - 5 2013.11
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IRON CHELATION THERAPY IMPROVES OXIDATIVE DNA DAMAGE IN HEMATOPOIETIC CELLS DERIVED FROM TRANSFUSION-DEPENDENT MYELODYSPLASTIC SYNDROME
Masayoshi Kobune, Shohei Kikuchi, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Kaoru Ono, Hiroto Horiguchi, Yusuke Kamihara, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato
AMERICAN JOURNAL OF HEMATOLOGY 88 ( 5 ) E98 - E98 2013.5
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Clinical Usefulness of Capsule Endoscopy With Flexible Spectral Imaging Color Enhancement for Diagnosis of Small Bowel Lesions
Tamotsu Sagawa, Yasushi Sato, Hiroyuki Ohnuma, Yasuhiro Sato, Hiroto Horiguchi, Tokiko Nakamura, Koshi Fujikawa, Yasuo Takahashi, Masayoshi Kobune, Rishu Takimoto, Hidetoshi Ohta, Michiaki Hirayama, Shinichi Katsuki, Junji Kato
GASTROINTESTINAL ENDOSCOPY 75 ( 4 ) 252 - 252 2012.4
Research Projects
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骨髄微細環境における神経－白血病系の解析
Grant number：24K11546 2024.4 - 2027.3
日本学術振興会 科学研究費助成事業 基盤研究(C)
堀口 拓人, 後藤 亜香利, 小船 雅義
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
髄内神経システムが正常造血及び造血障害に関与することが見出されつつあり、シナプス小胞内の神経ペプチドが造血幹細胞維持に関与することが報告された。しかしながら、神経－造血幹細胞系に関して報告されているものの、神経－白血病系については未だ報告はない。
神経ペプチドであるTuberoinfundibular peptide of 39 residues (TIP39)の受容体であるParathyroid hormone（PTH）2受容体 (PTH2R) の高発現が急性骨髄性白血病（AML）の予後不良であることを見出したが、その機能は不明であった。申請者は、TIP39を添加してAML細胞株を培養したところ、オートファジーが誘導されることを見出した。このため本研究では、神経ペプチドであるTIP39によりAML細胞株で誘導されたオートファジーの細胞内シグナル伝達などの詳細な解析、造血器腫瘍であるAMLにおけるTIP39誘導オートファジーの役割、骨髄微細環境内のTIP39産生細胞を同定、そして正常骨髄微細環境との比較により、AMLの新たな治療標的としての可能性を模索することを目指すものである。 -
Development of new therapy for AML by targeting of neuropeptide-PTH2R system
Grant number：22K08509 2022.4 - 2025.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Kobune Masayoshi
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
Analysis of public GEO datasets (GSE58831, GSE24395) demonstrated that PTH2R is markedly up-regulated in the CD34+CD38-leukemia stem-cell compartment of acute myeloid leukemia (AML) patients. High PTH2R expression correlated with inferior overall survival and retained prognostic significance independently of cytogenetic risk and gene-mutation status. In hematopoietic tumor cell lines, stimulation of the TIP39-PTH2R axis induced autophagy, evidenced by LC3-II accumulation, while concomitantly suppressing caspase-3-dependent apoptosis. Autophagic activation was accompanied by reduced phosphorylation of mTOR, and knock-down of PTH2R by siRNA abrogated this survival advantage, confirming receptor dependence. Collectively, these data identify the TIP39-PTH2R pathway as a critical regulator of AML stem-cell survival and highlight it as a promising molecular target for therapeutic intervention.
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Function of neuropeptide, TIP39, in bone marrow microenvironment with hematopoietic neoplasm
Grant number：21K16273 2021.4 - 2023.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
HORIGUCHI HIROTO
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
First, we analyzed proliferation of AML cell lines under TIP39 stimulation. The difference has not observed between culture with TIP39 and without TIP39.
Next, we conducted AML cell culture without serum, in starved condition, to research the effect to survival of AML cell. Surprisingly, TIP39-stimulated AML cells were significantly survival under starved condition. Moreover, increased LC3-II expression in TIP39-stimulated AML cell at one to two hours after the stimulation was observed compared to unstimulated AML cell by western blot analysis. In addition, under normal culture the increased LC3-II was also revealed in the stimulated cells. Furthermore, the proportion of apoptosis in TIP39-stimulated AML cell was decreased compared to unstimulated AML cell. These results suggest that TIP39-induced autophagy could affect survival advantage over normal cell. -
Role of KAISO and P120 complex in lymphoid leukemia
Grant number：19K23921 2019.8 - 2021.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up
Horiguchi Hiroto
Grant amount：\2860000 （ Direct Cost: \2200000 、 Indirect Cost：\660000 ）
We purchased acute leukemia cell lines (BALL-1, HAL-01, NALM-6, TALL, MOLT-4, and Jurkat). They were cultured and their RNAs were extracted by using TRIzol.
Reverse transcription quantitative polymerase chain reaction (RT-qPCR) revealed that KAISO mRNAs of BALL-1 and HAL-01 were significantly decreased than normal B cell and KAISO mRNAs of TALL, MOLT-4, and Jurkat were significantly decreased than normal T cell. Moreover, Catenin delta-1 mRNAs of all B cell leukemia lines and T cell leukemia cell lines were significantly decreased than normal B cell and T cell, respectively. -
The effect of exosomal miRNA on AML/MDS stromal cells
Grant number：15K09482 2015.4 - 2018.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Kobune Masayoshi
Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）
The failure of normal hematopoiesis is observed in myeloid neoplasms. However, the precise mechanisms governing replacement of normal hematopoietic stem cells in their niche by myeloid neoplasm stem cells have not been clarified yet. Primary acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) cells induced aberrant expression of multiple hematopoietic factors including JAG1, SCF and ANGPT1 in mesenchymal stem cells. Importantly, transfer of myeloid neoplasm-derived extracellular vesicles reduced the hematopoietic-supportive capacity of mesenchymal stem cells. Analysis of exosomal microRNA indicated that several species including miR-7977 from acute myeloid leukemia cells were higher than those from normal CD34+ cells. Remarkably, the copy number of miR-7977 in BM interstitial fluid was elevated in not only AML, but also MDS, as compared with control bone marrow. Thus, miR-7977 in extracellular vesicles may be a critical factor that induces failure of normal hematopoiesis.