OGAWA Toshihumi

写真a

Affiliation

School of Medicine, Department of Physiology

Job title

Assistant Professor
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Education 【 display / non-display 】

  • 2018
    -
    2023

    Sapporo Medical University   Graduate School of Medicine   地域医療人間総合医学専攻 発生分化・加齢制御医学領域 心血管細胞代謝病態学  

  • 2008
    -
    2014

    Sapporo Medical University   医学部   医学科  

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Research Experience 【 display / non-display 】

  • 2023.04
    -
    Now

    Sapporo Medical University   School of Medicine Medical Sciences   助教

  • 2020.04
    -
    2023.03

    JR札幌病院   循環器内科／腎臓内科／糖尿病内科   医長

  • 2019.04
    -
    2020.03

    札幌循環器病院   内科・循環器内科  

  • 2018.12
    -
    2019.03

    Sapporo Medical University   循環器・腎臓・代謝内分泌内科学講座  

  • 2018.08
    -
    2018.11

    北海道立江差病院   循環器内科  

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Professional Memberships 【 display / non-display 】

  • 2024.02
    -
    Now

    日本肥満学会

  • 2024.01
    -
    Now

    日本生理学会

  • 2022.04
    -
    Now

    日本内分泌学会

  • 2021.05
    -
    Now

    日本心不全学会

  • 2019.12
    -
    Now

    日本糖尿病学会

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Research Areas 【 display / non-display 】

  • Life sciences   Cardiology  

  • Life sciences   Physiology  

  • Life sciences   Metabolism and endocrinology  

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Affiliation 【 display / non-display 】

  • Sapporo Medical University   医学部細胞生理学講座   助教  

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Research Interests 【 display / non-display 】

  • 糖尿病性心筋症

  • サルコペニア

  • 糖尿病

  • 代謝

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Papers 【 display / non-display 】

  • Machine learning-based analyses of contributing factors for the development of hypertension: a comparative study.

    Marenao Tanaka, Yukinori Akiyama, Kazuma Mori, Itaru Hosaka, Keisuke Endo, Toshifumi Ogawa, Tatsuya Sato, Toru Suzuki, Toshiyuki Yano, Hirofumi Ohnishi, Nagisa Hanawa, Masato Furuhashi

    Clinical and experimental hypertension (New York, N.Y. : 1993)   47 ( 1 ) 2449613 - 2449613  2025.12  [International journal]

    　View Summary

    OBJECTIVES: Sufficient attention has not been given to machine learning (ML) models using longitudinal data for investigating important predictors of new onset of hypertension. We investigated the predictive ability of several ML models for the development of hypertension. METHODS: A total of 15 965 Japanese participants (men/women: 9,466/6,499, mean age: 45 years) who received annual health examinations were randomly divided into a training group (70%, n = 11,175) and a test group (30%, n = 4,790). The predictive abilities of 58 candidates including fatty liver index (FLI), which is calculated by using body mass index, waist circumference and levels of γ-glutamyl transferase and triglycerides, were investigated by statistics analogous to the area under the curve (AUC) in receiver operating characteristic curve analyses using ML models including logistic regression, random forest, naïve Bayes, extreme gradient boosting and artificial neural network. RESULTS: During a 10-year period (mean period: 6.1 years), 2,132 subjects (19.1%) in the training group and 917 subjects (19.1%) in the test group had new onset of hypertension. Among the 58 parameters, systolic blood pressure, age and FLI were identified as important candidates by random forest feature selection with 10-fold cross-validation. The AUCs of ML models were 0.765-0.825, and discriminatory capacity was significantly improved in the artificial neural network model compared to that in the logistic regression model. CONCLUSIONS: The development of hypertension can be simply and accurately predicted by each ML model using systolic blood pressure, age and FLI as selected features. By building multiple ML models, more practical prediction might be possible.

    DOI PubMed

  • Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Is an Independent Risk Factor for the Development of Ischemic Heart Disease ― A 10-Year Cohort Study ―

    Toshifumi Ogawa, Tatsuya Sato, Marenao Tanaka, Yukinori Akiyama, Kei Nakata, Hidemichi Kouzu, Kazuma Mori, Hiroki Aida, Wataru Kawaharata, Itaru Hosaka, Toru Suzuki, Nagisa Hanawa, Masato Furuhashi

    Circulation Reports ( Japanese Circulation Society )   2025.04

    DOI

  • Unraveling Novel Subsets of Lymphocytes Involved in Sac Expansion in the Tertiary Lymphoid Structure Within an Abdominal Aortic Aneurysm.

    Itaru Hosaka, Ippei Ikegami, Takuma Mikami, Tatsuya Sato, Toshifumi Ogawa, Kei Mukawa, Marenao Tanaka, Keisuke Endo, Yukinori Akiyama, Akihito Ohkawa, Junji Nakazawa, Tsuyoshi Shibata, Tomohiro Nakajima, Yutaka Iba, Chikara Shiiku, Satoshi Sumino, Ryuji Koshima, Kenichi Takano, Shingo Ichimiya, Nobuyoshi Kawaharada, Masato Furuhashi

    Journal of the American Heart Association   14 ( 6 ) e040279  2025.03  [International journal]

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    BACKGROUND: Chronic inflammation is involved in the development of abdominal aortic aneurysm (AAA). A tertiary lymphoid structure (TLS) within vascular lesions has recently been focused on for its role in modulation of inflammation in local tissues. We aimed to elucidate the relationships between TLS and pathophysiology of AAA. METHODS: Abdominal aortic samples obtained from 37 patients with AAA (men/women: 34/3, age: 72.8±9.9 years) and 15 autopsied patients who died from non-aortic events (men/women: 11/4, age: 65.5±9.8 years) were investigated. RESULTS: TLSs in AAA lesions were confirmed by focal infiltration of CD3-positive cells surrounding germinal center-like structures containing CD20-positive cells between the tunica adventitia and tunica media layers. The formation of a TLS was significantly more prevalent in AAA patients than in autopsied patients. The number of TLSs in AAA lesions was positively correlated with sac diameter (r=0.357, P=0.035) and the amount of intraluminal thrombosis (r=0.466, P=0.005). T cells and B cells were predominant cellular populations among CD45+ cells in AAA lesions. There was a significantly positive correlation between the proportions of interfollicular T follicular helper (CD3+CD4+CD45RA-CXCR5+PD-1+) cells and double negative B (CD3-CD19+IgD-CD27-) cells, and they were positively correlated with sac diameter, intraluminal thrombosis, and serum lipids. Deposited single-cell RNA-sequencing data for AAA showed that T follicular helper cells and double negative B cells were associated with lipid metabolism, T cell activation/proliferation and inflammation. CONCLUSIONS: The formation of a TLS in AAA lesions is associated with sac diameter and intraluminal thrombosis in connection with interfollicular T follicular helper cells and double negative B cells, which may contribute to the pathophysiology of AAA and might be novel therapeutic targets for the development of AAA.

    DOI PubMed

  • The Combination of PPARα Agonist GW7647 and Imeglimin Has Potent Effects on High-Glucose-Induced Cellular Biological Responses in Human Retinal Pigment Epithelium Cells.

    Nami Nishikiori, Megumi Watanabe, Megumi Higashide, Araya Umetsu, Toshifumi Ogawa, Masato Furuhashi, Hiroshi Ohguro, Tatsuya Sato

    Bioengineering (Basel, Switzerland)   12 ( 3 )  2025.03  [International journal]

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    BACKGROUND: Hyperglycemic changes in the cellular biological properties of retinal pigment epithelium cells are involved in the pathophysiology of diabetic retinopathy (DR). To assess the effects of the new anti-diabetic agent imeglimin (Ime) on DR, the pharmacological effects of Ime and those of metformin (Met) in combination with the PPARα agonist GW7646 (GW) on adult retinal pigment epithelium (ARPE19) cells cultured in high-glucose conditions were compared. METHODS: Cell viability, levels of reactive oxygen species (ROS), monolayer barrier function measured by transepit very much helial electrical resistance (TEER), and metabolic functions determined by an extracellular flux analyzer were evaluated. RESULTS: While glucose concentrations did not alter cell viability regardless of the presence of Met or Ime, levels of ROS were significantly increased by the high-glucose conditions, and increased levels of ROS were significantly alleviated by the combination of Ime and GW but not by Met alone. Similarly, TEER values were increased by high-glucose conditions, but the effects of high-glucose conditions were dramatically enhanced by the combination of Ime and GW. Furthermore, a metabolic assay showed that an energetic shift was induced by the combination of Ime and GW, whereas energy status became quiescent with Met or Ime alone. CONCLUSIONS: The collective results suggest that Ime in combination with GW has synergetic effects on high-glucose-induced cellular biological changes in ARPE19 cells.

    DOI PubMed

  • LINC02154 promotes cell cycle and mitochondrial function in oral squamous cell carcinoma.

    Takeshi Niinuma, Hiroshi Kitajima, Tatsuya Sato, Toshifumi Ogawa, Kazuya Ishiguro, Masahiro Kai, Eiichiro Yamamoto, Yui Hatanaka, Iyori Nojima, Mutsumi Toyota, Akira Yorozu, Shohei Sekiguchi, Noritsugu Tohse, Masato Furuhashi, Hiroshi Ohguro, Akihiro Miyazaki, Hiromu Suzuki

    Cancer science   116 ( 2 ) 393 - 405  2025.02  [International journal]

    　View Summary

    Long noncoding RNAs (lncRNAs) play pivotal roles in the development of human malignancies, though their involvement in oral squamous cell carcinoma (OSCC) remains incompletely understood. Using The Cancer Genome Atlas (TCGA) dataset, we analyzed expression of 7840 lncRNAs in primary head and neck squamous cell carcinoma (HNSCC) and found that upregulation of LINC02154 is associated with a poorer prognosis. LINC02154 knockdown in OSCC cell lines induced cell cycle arrest and apoptosis, and significantly attenuated tumor growth in vitro and in vivo. Notably, depletion of LINC02154 downregulated FOXM1, a master regulator of cell cycle-related genes. RNA pulldown and mass spectrometry analyses identified a series of proteins that could potentially interact with LINC02154, including HNRNPK and LRPPRC. HNRNPK stabilizes FOXM1 expression by interacting with the 3'-UTR of FOXM1 mRNA, which suggests LINC02154 and HNRNPK promote cell cycling by regulating FOXM1 expression. Additionally, LINC02154 positively regulates HNRNPK expression by inhibiting microRNAs targeting HNRPNK. Moreover, LINC02154 affects mitochondrial function by interacting with LRPPRC. Depletion of LINC02154 suppressed expression of mitochondrial genes, including MTCO1 and MTCO2, and inhibited mitochondrial respiratory function in OSCC cells. These results suggest that LINC02154 exerts its oncogenic effects by modulating the cell cycle and oxidative phosphorylation in OSCC, highlighting LINC02154 as a potential therapeutic target.

    DOI PubMed

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Misc 【 display / non-display 】

  • セマグルチド注射薬により20年間のインスリン強化療法から離脱できた2型糖尿病の1例

    寺沢 誠, 中田 圭, 大久保 武志, 小川 俊史, 隅田 健太郎, 佐藤 達也, 神津 英至, 矢野 俊之, 古橋 眞人

    糖尿病 ( (一社)日本糖尿病学会 )  67 ( 12 ) 511 - 511  2024.12

  • 腹腔鏡下胃スリーブ状切除術によりインスリン抵抗性-インスリン必要量増加-体重増加の悪循環を脱し、肥満関連合併症の改善が得られた1例

    小川 俊史, 佐藤 達也, 大久保 武志, 寺沢 誠, 中田 圭, 隅田 健太郎, 神津 英至, 矢野 俊之, 矢島 諒人, 伊東 竜哉, 竹政 伊知朗, 古橋 眞人

    日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  100 ( 4 ) 805 - 805  2024.12

  • Contribution of MLKL to the Development of Doxorubicin-induced Cardiomyopathy(タイトル和訳中)

    清水 将輝, 大和田 渉, 矢野 俊之, 神津 英至, 佐藤 達也, 長南 新太, 小川 俊史, 戸田 悠貴, 久野 篤史, 丹野 雅也, 古橋 眞人

    日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  88回   PJ073 - 1  2024.03

  • Impact of Mitochondrial Dynamics on Necroptosis in Cardiomyocytes(タイトル和訳中)

    戸田 悠貴, 矢野 俊之, 久野 篤史, 丹野 雅也, 神津 英至, 佐藤 達也, 大和田 渉, 舘越 勇輝, 小川 俊史, 清水 将輝, 古橋 眞人

    日本循環器学会学術集会抄録集 ( (一社)日本循環器学会 )  88回   PJ080 - 3  2024.03

  • 肥満減量術後慢性期の血糖コントロール悪化にセマグルチドが著効した2型糖尿病の症例

    赤澤 史子, 小川 俊史, 中田 圭, 佐藤 達也, 伊東 竜哉, 竹政 伊知朗, 古橋 眞人

    糖尿病 ( (一社)日本糖尿病学会 )  67 ( 1 ) 37 - 37  2024.01

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Research Projects 【 display / non-display 】

  • Roles of Ferroptosis in Steatotic Liver Disease as a Pathophysiology of Cardiovascular, Kidney, and Metabolic (CKM) Syndrome

    Grant-in-Aid for Scientific Research (C)

    Project Year :

    2025.04
    -
    2028.03
     

    Tatsuya Sato, Megumi Watanabe, Nobutoshi Ichise, Toshifumi Ogawa

  • AMPデアミナーゼを介する代謝の再配線に着目したサルコペニアの病態の解明

    若手研究

    Project Year :

    2024.04
    -
    2027.03
     

    小川 俊史

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