2026/05/22 更新

写真a

タカハシ ユウキ
髙橋 有毅
所属
医学部 外科学講座呼吸器外科学分野 助教
職名
助教
ORCID ID
0000-0002-3724-7248
外部リンク

学位

  • 博士 ( 2021年3月   札幌医科大学 )

研究分野

  • ライフサイエンス / 呼吸器外科学

経歴

  • 札幌医科大学   外科学講座 呼吸器外科学分野   助教

    2024年7月 - 現在

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論文

  • Hydroxyapatite microspheres induce durable pleurodesis and are rapidly cleared by pleural osteoclasts

    Yusuke Tanaka, Yuki Takahashi, Yuma Shindo, Lori B. Pitstick, Steven L. Teitelbaum, Wei Zou, Xiangning Wang, Jason C. Woods, Kathryn A. Wikenheiser-Brokamp, Francis X. McCormack

    JCI Insight   2025年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1172/jci.insight.192981

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  • Histological evaluation of human pulmonary artery intimal damage caused by various clamp techniques

    Yoshiki Chiba, Masahiro Miyajima, Yuki Takahashi, Kodai Tsuruta, Ryunosuke Maki, Hirofumi Adachi, Atsushi Watanabe

    European Journal of Cardio-Thoracic Surgery   2025年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    Abstract

    OBJECTIVES

    We evaluated intimal damage at the histological level resulting from various clamp techniques in human pulmonary artery specimens obtained after lobectomy.

    METHODS

    We prospectively analysed patients who underwent anatomical lung resection at two centres between April 2021 and March 2025. The double-loop technique (DLT), DeBakey vascular clamp (3rd and 4th notches), Fogarty vascular clamp (2nd notch), endovascular clips (gold and silver), and vessel loop technique (VLT) were evaluated. Pulmonary artery specimens with an external diameter ≥10 mm were included. We measured the burst pressure and evaluated the intimal damage in the human pulmonary artery by using the modified Zhang’s score (MZS; 0 − 5).

    RESULTS

    Thirty-six patients were enrolled, and 70 pulmonary artery samples were obtained. DeBakey 3rd exerted a significantly higher burst pressure than did DLT (P = 0.022). No significant difference was found between DLT and VLT (P = 0.453). A burst pressure ≥30 mmHg was achieved in all DLT cases. None of the samples clamped with DLT and VLT exhibited MZS 3 − 5. The rate of MZS ≥2 with DeBakey 3rd, Fogarty 2nd, gold and silver clips, and VLT was statistically comparable to that for DLT, whereas DeBakey 4th resulted in significantly higher MZS values than did DLT (P = 0.029).

    CONCLUSIONS

    The DLT is a feasible and safe for thoracoscopic clamping. Additionally, DLT, VLT, and gold clip are appropriate for clamping the peripheral pulmonary artery. For DeBakey vascular clamp, notch selection should be carefully tailored to the vessel diameter.

    DOI: 10.1093/ejcts/ezaf232

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  • Suture-based rib approximation for the repair of minimally invasive surgery-related lung hernia: a case series

    Yuki Takahashi, Masahiro Miyajima, Ryunosuke Maki, Yoshiki Chiba, Takeshi Ohyu, Kazuki Sato, Kazuya Honda, Atsushi Watanabe

    Journal of Surgical Case Reports   2025 ( 7 )   2025年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    Abstract

    Lung hernia is a rare complication of minimally invasive surgery (MIS). Suture-based rib approximation to restore costal margin continuity during MIS-related lung hernia repair has not been reported. We present three cases of repair using suture-based rib approximation for MIS-related lung hernias. Between 2016 and 2025, our department performed four MIS-related lung hernia repairs. Three followed minimally invasive cardiac surgery (MICS), and one followed video-assisted thoracoscopic surgery (VATS). We excluded the MICS case requiring third-rib resection during MICS and Gore-Tex patch for repair. All MICS-related hernias occurred at the right fourth intercostal space; the VATS-related hernia occurred at the left fourth intercostal space. In all three cases, hernial defects were repaired with sutures placed across the intercostal space between the upper and lower ribs. No perioperative mortality, morbidity, or recurrence occurred. Suture-based rib approximation demonstrated favorable outcomes. Further case accumulation is necessary to identify risk factors and establish optimal techniques.

    DOI: 10.1093/jscr/rjaf518

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  • Comparison of imaging changes in pulmonary artery diameter at the occlusion site using silk or metal clamps for pulmonary artery troubles

    Yoshiki Chiba, Masahiro Miyajima, Yuki Takahashi, Yuma Shindo, Kodai Tsuruta, Ryunosuke Maki, Atsushi Watanabe

    European Journal of Cardio-Thoracic Surgery   65 ( 3 )   2024年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    Abstract

    <p></p> OBJECTIVES

    We analysed our clinical experience using silk sutures [the double-loop technique (DLT)] or DeBakey type vascular clamp (DeBakey clamp) for pulmonary artery (PA) troubles during anatomical lung resection to validate its practicality and safety.

    METHODS

    We retrospectively reviewed the records of patients who underwent either of the above clamping techniques during anatomical lung resection at our hospital between April 2007 and August 2022. We measured the PA diameter at the occlusion site on computed tomography images acquired within 1 year pre- and postoperatively. The difference between pre- and postoperative diameters of the occlusion sites was calculated as the change in the PA diameter. We zoned the occlusion site of the PA to adjust for variation. PA deformation was evaluated as an adverse event caused by clamping.

    RESULTS

    Ultimately, 27 and 26 patients who underwent the DLT and DeBakey clamp, respectively, were included. No additional injury due to the clamp procedure was found in either group. For zone R1/L1, defined as the main PA, the median changes in the PA diameter were 0.02 (–0.7 to 0.27) mm for the DLT and 0.36 (–0.28 to 0.89) mm for the DeBakey clamp. No significant differences were observed between the 2 groups (P = 0.106). Furthermore, no aneurysms, dissections, or stenoses were found in either group.

    CONCLUSIONS

    The DLT and DeBakey clamp had only minimal effects on the occlusion site of the PA. The DLT is a practical thoracoscopic technique for PA bleeding when primary haemostasis has been achieved.

    その他リンク: https://academic.oup.com/ejcts/article-pdf/65/3/ezae034/56886996/ezae034.pdf

    DOI: 10.1093/ejcts/ezae034

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  • Experimental and histological evaluation of different clamp technique for pulmonary artery

    Yoshiki Chiba, Yuki Takahashi, Yoshiaki Takase, Kodai Tsuruta, Ryunosuke Maki, Masahiro Miyajima, Hirofumi Ohnishi, Atsushi Watanabe

    Interdisciplinary CardioVascular and Thoracic Surgery   37 ( 3 )   2023年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    Abstract

    <p></p> OBJECTIVES

    The double-loop technique has been used in our clinical settings for pulmonary arterioplasty and/or injured artery repair during thoracoscopic anatomical lung resection. We evaluated the pressure resistance capacity and intimal load to determine the effectiveness and safety of the double-loop technique.

    METHODS

    The double-loop technique, DeBakey clamp, Fogarty clamp, endovascular clips and vessel loop technique were evaluated. During an experimental study, a polyvinyl alcohol main pulmonary artery model, manometer and in-deflation device were used to measure the burst pressure. The maximum clamp pressure was measured using a pressure-measuring film. Each measurement was performed 10 times. During the histological study, we measured the burst pressure and evaluated the intimal damage of the human pulmonary artery associated with the double-loop technique and DeBakey clamp.

    RESULTS

    The experimental burst pressure (mmHg) and maximum clamp pressure (MPa) between the double-loop technique and DeBakey at the third notch were not significantly different (24.6 ± 2.8 and 21.8 ± 2.8, P = 0.094; 1.54 ± 0.12 and 1.49 ± 0.12, P = 0.954). During the histological study, the burst pressures of the double-loop technique and DeBakey at the third notch were also not significantly different (P = 0.754). Furthermore, the double-loop technique resulted in only intimal deformation in each five samples.

    CONCLUSIONS

    The double-loop technique is feasible for thoracoscopic anatomical lung resection because it has similar pressure resistance capacity and intimal load as DeBakey at the 3rd notch.

    その他リンク: https://academic.oup.com/icvts/article-pdf/37/3/ivad119/51548260/ivad119.pdf

    DOI: 10.1093/icvts/ivad119

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  • Recognition of subsuperior segmental vein for thoracoscopic subsuperior segmentectomy

    Daichi Ishii, Yoshiaki Takase, Ryunosuke Maki, Yoshiki Chiba, Yuki Takahashi, Kodai Tsuruta, Masahiro Miyajima, Atsushi Watanabe

    JTCVS Techniques   19   135 - 139   2023年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.xjtc.2023.03.016

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  • Clinical effect of soft coagulation for air leak treatment during pulmonary lobectomy

    Yuki Takahashi, Ryunosuke Maki, Kodai Tsuruta, Makoto Tada, Wataru Arai, Yuma Shindo, Yasuyuki Nakamura, Masahiro Miyajima, Atsushi Watanabe

    Journal of Cardiothoracic Surgery   17 ( 1 )   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media {LLC}  

    <jats:title>Abstract</jats:title><jats:sec>
    <jats:title>Background</jats:title>
    <jats:p>Soft coagulation using the VIO soft coagulation system is used to treat minor lung air leaks during pulmonary resection in Japan. We previously reported that it has a similar effect as the air leak treatment with fibrin glue. We evaluated the efficacy of soft coagulation using the VIO soft coagulation system for lung air leakage during pulmonary resection.</jats:p>
    </jats:sec><jats:sec>
    <jats:title>Methods</jats:title>
    <jats:p>Intraoperative air leaks from the interlobar lung parenchyma were observed in 42 of the 283 patients who underwent video-assisted thoracoscopic surgery lobectomy between 2016 and 2018. We retrospectively reviewed these 42 patients who were treated using the VIO soft coagulation system for air leaks. We classified the air leaks in to grades using the Macchiarini scale score and evaluated the surgical outcomes of air leak treatment.</jats:p>
    </jats:sec><jats:sec>
    <jats:title>Results</jats:title>
    <jats:p>Air leaks from the interlobar lung parenchyma having Macchiarini scale scores 1, 2, and 3 occurred in 8, 17, and 17 patients, respectively. In all the 8 patients with score 1 air leaks (100%), the air leaks could be controlled using the VIO soft coagulation system alone, and none had delayed pneumothorax requiring intervention. Of the score 2 and 3 air leaks, 52.9% and 35.3% were controlled using the VIO soft coagulation system alone, respectively.</jats:p>
    </jats:sec><jats:sec>
    <jats:title>Conclusions</jats:title>
    <jats:p>Macchiarini scale score 1 air leaks from the interlobar lung parenchyma could be well controlled using the VIO soft coagulation system. Therefore, soft coagulation with this system may be an alternative method for treating minor air leaks during pulmonary resection surgery.</jats:p>
    </jats:sec>

    DOI: 10.1186/s13019-022-01948-x

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  • Number of lymph nodes dissected and upstaging rate of the N factor in robot-assisted thoracic surgery versus video-assisted thoracic surgery for patients with cN0 primary lung cancer

    Yuma Shindo, Masahiro Miyajima, Yasuyuki Nakamura, Yoshiki Chiba, Wataru Arai, Miho Aoyagi, Ryunosuke Maki, Kodai Tsuruta, Yuki Takahashi, Makoto Tada, Yoshiaki Takase, Atsushi Watanabe

    Surgery Today   53 ( 4 )   428 - 434   2022年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    その他リンク: https://link.springer.com/article/10.1007/s00595-022-02578-5/fulltext.html

    DOI: 10.1007/s00595-022-02578-5

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  • Pulmonary vessels and bronchus anatomy of the left upper lobe

    Maki, R., Miyajima, M., Ogura, K., Tada, M., Takahashi, Y., Adachi, H., Watanabe, A.

    Surgery Today   52 ( 4 )   2022年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00595-022-02471-1

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  • Treatment of air leakage using the VIO soft coagulation system: a mouse pulmonary air leak model

    Takahashi, Y., Saito, A., Sakuma, Y., Tada, M., Maki, R., Takahashi, M., Watanabe, A.

    Surgery Today   51 ( 9 )   2021年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00595-021-02251-3

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  • Risk factors for atelectasis of the middle lobe after right upper lobectomy: Preoperative bronchial diameter and stapling of the fissure

    Mizukami, Y., Takahashi, Y., Maki, R., Adachi, H.

    Journal of Thoracic Disease   13 ( 10 )   2021年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.21037/jtd-21-1081

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  • Vessel sealing system for video-assisted lung resection for cancer reduces chylothorax and bleeding

    Miyajima, M., Maki, R., Tada, M., Tsuruta, K., Takahashi, Y., Arai, W., Watanabe, A.

    Journal of Thoracic Disease   13 ( 6 )   2021年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.21037/jtd-21-169

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  • Efficacy of Automatic Retention Pressure of a Double-Lumen Tube Cuff: An Artificial Intubation Model

    Takahashi, Y., Tokinaga, Y., Edanaga, M., Kikuchi, K., Tada, M., Maki, R., Yamakage, M., Watanabe, A.

    Journal of Surgical Research   257   2021年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jss.2020.08.017

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  • Primary capicua transcriptional repressor-rearranged sarcoma of the lung

    Mizukami, Y., Takahashi, Y., Sugita, S., Wakabayashi, K., Suzuki, H., Hasegawa, T., Noguchi, H., Adachi, H.

    Japanese Journal of Clinical Oncology   51 ( 4 )   2021年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jjco/hyaa240

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  • Single-port vs conventional three-port video-assisted thoracoscopic pulmonary wedge resection: Comparison of postoperative pain and surgical costs

    Mizukami, Y., Takahashi, Y., Adachi, H.

    Annals of Thoracic and Cardiovascular Surgery   27 ( 2 )   2021年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.5761/atcs.oa.20-00142

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  • Anatomy of the left subsuperior segment for segmentectomy

    Maki, R., Miyajima, M., Ogura, K., Tada, M., Takahashi, Y., Adachi, H., Watanabe, A.

    Surgery Today   2021年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00595-021-02417-z

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  • Pulmonary vessels and bronchial anatomy of the left lower lobe

    Maki, R., Miyajima, M., Ogura, K., Tada, M., Takahashi, Y., Arai, W., Adachi, H., Watanabe, A.

    Surgery Today   50 ( 9 )   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00595-020-01991-y

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  • Quality assessment using EQ-5D-5L after lung surgery for non-small cell lung cancer (NSCLC) patients

    Koide, R., Kikuchi, A., Miyajima, M., Mishina, T., Takahashi, Y., Okawa, M., Sawada, I., Nakajima, J., Watanabe, A., Mizuguchi, T.

    General Thoracic and Cardiovascular Surgery   67 ( 12 )   2019年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11748-019-01136-0

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  • Pulmonary staple-stump granuloma after segmentectomy: Two case reports and comparison with cases of stump recurrence

    Mizukami, Y., Takahashi, Y., Adachi, H.

    American Journal of Case Reports   20   2019年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.12659/AJCR.916906

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  • Surgical Treatment for Pneumopyothorax Secondary to Pancreatic Fistula

    Ohkawa, M., Arai, W., Takahashi, Y., Maki, R., Tada, M., Mishina, T., Miyajima, M., Watanabe, A.

    Kyobu geka. The Japanese journal of thoracic surgery   72 ( 3 )   2019年

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    掲載種別:研究論文(学術雑誌)  

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  • Paraffinoma with Spinal Paralysis 40 Years After Pleural Plombage for Tuberculosis

    Arai, W., Ohkawa, M., Takahashi, Y., Tada, M., Maki, R., Mishina, T., Miyajima, M., Watanabe, A.

    Kyobu geka. The Japanese journal of thoracic surgery   72 ( 5 )   2019年

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    掲載種別:研究論文(学術雑誌)  

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  • Outcomes of completion lobectomy long after segmentectomy

    Takahashi, Y., Miyajima, M., Tada, M., Maki, R., Mishina, T., Watanabe, A.

    Journal of Cardiothoracic Surgery   14 ( 1 )   2019年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s13019-019-0941-8

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  • Thoracoscopic Right Basilar Segmentectomy After Right Upper Lobectomy

    Tada, M., Miyajima, M., Mishina, T., Takahashi, Y., Maki, R., Watanabe, A.

    Annals of Thoracic Surgery   107 ( 2 )   2019年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.athoracsur.2018.06.041

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  • Patient outcomes post-pulmonary resection for synchronous bone-metastatic non-small cell lung cancer

    Takahashi, Y., Adachi, H., Mizukami, Y., Yokouchi, H., Oizumi, S., Watanabe, A.

    Journal of Thoracic Disease   11 ( 9 )   2019年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.21037/jtd.2019.09.17

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  • Video-assisted thoracoscopic segmentectomy of right lung cancer with extracorporeal lung assist after left completion pneumonectomy

    Tada, M., Takahashi, Y., Maki, R., Mishina, T., Miyajima, M., Watanabe, A.

    Japanese Journal of Lung Cancer   58 ( 4 )   2018年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2482/haigan.58.298

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  • p40 Negative Basaloid Squamous Cell Carcinoma of the Lung;Report of a Case

    Maki, R., Sugita, S., Ono, Y., Miyajima, M., Tada, M., Takahashi, Y., Mishina, T., Watanabe, A.

    Kyobu geka. The Japanese journal of thoracic surgery   71 ( 7 )   2018年

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    掲載種別:研究論文(学術雑誌)  

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  • Thoracoscopic one-stage lobectomy and diaphragmatic plication for T3 lung cancer

    Takahashi, Y., Miyajima, M., Mishina, T., Maki, R., Tada, M., Tsuruta, K., Watanabe, A.

    Journal of Cardiothoracic Surgery   13 ( 1 )   2018年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s13019-018-0766-x

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  • Feasibility of Pulmonary Resection for Lung Cancer in Patients With Coronary Artery Disease or Atrial Fibrillation

    Kitamura, Y., Suzuki, K., Teramukai, S., Sonobe, M., Toyooka, S., Nakagawa, Y., Yokomise, H., Date, H., Arikura, J., Miyajima, M., Tsunooka, N., Ueda, S., Shiono, S., Ichimura, H., Ohtaki, Y., Kawashima, O., Takahashi, N., Iwata, T., Murakawa, T., Shimada, Y., Horio, H., Ishibashi, H., Kawachi, R., Omori, T., Naito, M., Hashimoto, T., Waseda, R., Tsunezuka, Y., Tanaka, N., Eguchi, T., Agatsuma, H., Mizuno, Y., Nishikawa, S., Isaka, M., Haneda, H., Narita, K., Okuda, K., Kobayashi, Y., Terada, Y., Takemoto, T., Nakajima, R., Kanzaki, R., Okami, J., Kadota, Y., Hanaoka, N., Hayashi, A., Nishio, W., Takahashi, Y., Nakamura, H., Taniguchi, Y., Yamashina, A., Yamamoto, H., Miyata, Y., Matsuura, M., Tanaka, T., Matsuura, N., Suehisa, H., Chang, S.S., So, T., Osaki, T., Takeo, S., Takenoyama, M., Miyazaki, T., Marutsuka, T., Yoshimoto, K., Kariatsumari, K., Yanagi, M.

    Annals of Thoracic Surgery   103 ( 2 )   2017年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.athoracsur.2016.08.077

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  • Tracheal sleeve resection and reconstruction for a senile patient with adenoid cystic carcinoma

    Tada, M., Takahashi, Y., Maki, R., Mishina, T., Miyajima, M., Watanabe, A.

    Japanese Journal of Lung Cancer   57 ( 7 )   2017年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2482/haigan.57.870

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  • Video-assisted thoracoscopic surgery node dissection for lung cancer treatment

    Watanabe, A., Miyajima, M., Mishina, T., Tsuruta, K., Takahashi, Y., Maki, R., Tada, M.

    Surgery Today   47 ( 12 )   2017年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00595-017-1494-x

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▼全件表示

講演・口頭発表等

  • 肺癌区域切除後のVATS Completion lobectomy(CL)の経験~CLを見据えた初回手術の工夫~

    第42回日本呼吸器外科学会学術集会  2025年5月 

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    開催年月日: 2025年5月

    記述言語:日本語   会議種別:シンポジウム・ワークショップ パネル(公募)  

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  • 肺癌区域切除後のVATS Completion lobectomy

    第32回日本内視鏡外科学会総会 

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    会議種別:シンポジウム・ワークショップ パネル(公募)  

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  • VIO soft-coagulation systemによる肺瘻コントロールの有効性についての検討

    第74回日本胸部外科学会定期学術集会 

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    会議種別:シンポジウム・ワークショップ パネル(公募)  

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