Education 【 display / non-display 】

Education 【 display / non-display 】

• 2016

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  2019

  Sapporo Medical University Graduate School of Medicine  

• 2009

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  2015

  Sapporo Medical University   医学部   医学科  

Degree 【 display / non-display 】

Degree 【 display / non-display 】

• 2019.09   Sapporo Medical University Graduate School of Medicine   MD, PhD

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2022.04

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  Now

  函館五稜郭病院   呼吸器外科   医長

• 2020.04

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  2022.03

  函館五稜郭病院   呼吸器外科   医員

• 2019.10

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  2020.03

  独立行政法人国立病院機構 北海道がんセンター   呼吸器外科   医師

• 2017.04

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  2019.09

  札幌医科大学付属病院   呼吸器外科   医師

• 2016.04

  -

  2017.03

  函館五稜郭病院   初期臨床研修医

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Affiliation 【 display / non-display 】

Affiliation 【 display / non-display 】

• Sapporo Medical University School of Medicine   Department of thoracic surgery  

Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Anatomy of the left subsuperior segment for segmentectomy.

  Ryunosuke Maki, Masahiro Miyajima, Keishi Ogura, Makoto Tada, Yuki Takahashi, Hirofumi Adachi, Atsushi Watanabe

  Surgery today   52 ( 7 ) 1054 - 1062  2022.07  [Domestic journal]

  　View Summary

  PURPOSE: The subsuperior segmental bronchi (B*) forms the subsuperior segment (S*) between the superior (S6) and basal segment (S7, S8, S9, S10) of the lung. However, the anatomical planes of S* remains undefined. The present study clarified the anatomical features of S*. METHODS: We reviewed the anatomical patterns of pulmonary vessels and the left lung bronchus in 539 patients using three-dimensional computed tomography. We report the anatomic structure in S*. RESULTS: A total of 537 patients were analyzed. B* was observed in 129 (24.0%) patients. The intersegmental vein between S6 and S* was complete in all cases. The absence of intersegmental veins of S* was observed in 77 (14.3%) patients, reaching 59.7% of B* cases. Twenty-two (4.1%) cases of B* diverged from the trunk of the basal bronchus, and about half of the B* branched to the dorsolateral (n = 77, 14.3%) or dorsal (n = 2, 0.37%) direction. CONCLUSION: Our study revealed the branching patterns of B* and anatomical intersegmental veins of S*. Our results provide useful information regarding anatomical segmentectomy including or adjusting to the left S*.

  DOI PubMed

• Pulmonary vessels and bronchus anatomy of the left upper lobe.

  Ryunosuke Maki, Masahiro Miyajima, Keishi Ogura, Makoto Tada, Yuki Takahashi, Hirofumi Adachi, Atsushi Watanabe

  Surgery today   52 ( 4 ) 550 - 558  2022.04  [Domestic journal]

  　View Summary

  PURPOSES: The bronchopulmonary vascular bifurcation patterns in the upper lobe of the left lung are diverse. Therefore, it is important for general thoracic surgeons to understand the detailed anatomy of the pulmonary segments when performing thoracoscopic anatomical pulmonary resection. This study aimed to analyze the bronchovascular patterns of the left upper lobe and summarize the anatomical information associated with pulmonary anatomical pulmonary resection. METHODS: We reviewed the anatomical patterns of pulmonary vessels and the left lung bronchus of 539 patients using computed tomography imaging data including those obtained using three-dimensional computed tomography. We herein report the anatomic structure in the left upper lobe. RESULTS: Regarding the superior division bronchi, a pattern of trifurcation into B1+2, B3, lingular division bronchus was observed in nine patients (1.7%). A pattern of proximal bifurcation of B4 was found in eight patients (1.5%). Regarding the lingular veins (LV), patterns of LV drainage into the left lower pulmonary vein were observed in 22 patients (4.1%). Regarding the pulmonary artery, mediastinal lingular arteries (MLA) were found in 161 patients (29.9%). CONCLUSION: The bifurcation patterns of the bronchovascular region in the upper lobe of the left lung were clarified. These results should be carefully noted when performing anatomical pulmonary resection.

  DOI PubMed

• Salvage Surgery for Bronchopleural Fistula Due to Durvalumab and Chemoradiation.

  Makoto Tada, Hirofumi Uehara, Takeshi Ohyu, Atsushi Watanabe

  The Annals of thoracic surgery    2021.12  [International journal]

  　View Summary

  Herein we describe a case of salvage lobectomy for a bronchopleural fistula secondary to durvalumab after chemoradiotherapy in initially unresectable non-small cell lung cancer. A 75-year-old man with adenocarcinoma, c-stage IIIB (T4N2M0) in the upper lobe of the right lung, received durvalumab after chemoradiotherapy. Fourteen months after durvalumab was discontinued, pneumonitis developed followed by peripheral bronchopleural fistula, and he unavoidably underwent salvage right upper lobectomy. The postoperative course was uneventful, and air leakage ceased. After chemoradiotherapy and durvalumab, refractory air leakage may develop that may require salvage surgery.

  DOI PubMed

• Unexpected haemorrhage from lateral thoracic artery following the removal of a pleural drainage tube.

  Keigo Matsuura, Makoto Tada, Toshiyuki Sumi, Koichi Osuda, Hisashi Nakata, Hirofumi Chiba

  Respirology case reports   9 ( 12 ) e0882  2021.12  [International journal]

  　View Summary

  Pulmonologists must be aware of the possible arterial bleeding even during the removal of a safely inserted drain.

  DOI PubMed

• MCL1 inhibition enhances the efficacy of docetaxel against airway-derived squamous cell carcinoma cells.

  Yuji Sakuma, Sachie Hirai, Toshiyuki Sumi, Makoto Tada, Takashi Kojima, Toshiro Niki, Miki Yamaguchi

  Experimental cell research   406 ( 2 ) 112763 - 112763  2021.09  [International journal]

  　View Summary

  MCL1 is an anti-apoptotic BCL2 family member that is often overexpressed in various malignant tumors. However, few reports have described the role of MCL1 in squamous cell carcinoma (SqCC) derived from airways including the lung. In this study, we examined whether MCL1 could be a novel druggable target for airway-derived SqCC, for which effective molecular targeted drugs are unavailable. We searched the Kaplan-Meier Plotter database and found that high MCL1 mRNA expression was significantly associated with shorter survival in patients with lower airway (lung) or upper airway (head and neck) derived SqCC. We also explored the Expression Atlas database and learned that authentic lung SqCC cell lines expressing both TP63 and KRT5 mRNA were extremely sparse among the publicly available "lung SqCC cell lines", with an exception being HARA cells. HARA cells were highly dependent on MCL1 for survival, and MCL1-depleted cells were not able to grow, and even declined in number, upon docetaxel (DTX) exposure in vitro and in vivo. Similar in vitro experimental findings, including those in a 3D culture model, were also obtained using Detroit 562 pharyngeal SqCC cells. These findings suggested that combined treatment with MCL1 silencing plus DTX appears highly effective against airway-derived SqCC.

  DOI PubMed

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• 難治性気胸の治療戦略 VIO soft-coagulation systemによる肺瘻コントロールの有効性についての検討

  高橋 有毅, 槙 龍之輔, 鶴田 航大, 多田 周, 新井 航, 進藤 悠真, 中村 泰幸, 宮島 正博, 渡辺 敦

  日本胸部外科学会定期学術集会 ( (一社)日本胸部外科学会 )  74回   LWS5 - 4  2021.10

• VIO soft-coagulation systemによる肺瘻修復メカニズムについての検討

  高橋 有毅, 多田 周, 槙 龍之輔, 宮島 正博, 渡辺 敦, 佐久間 裕司, 齋藤 充史

  日本呼吸器外科学会雑誌 ( (NPO)日本呼吸器外科学会 )  35 ( 3 ) RO23 - 6  2021.05

• 区域切除のための左肺下葉における気管支肺血管の解剖—Pulmonary vessels and bronchial anatomy of the left lower lobe

  槙 龍之輔, 宮島 正博, 小倉 圭史, 多田 周, 高橋 有毅, 安達 大史, 渡辺 敦, Wataru Arai

  北海道外科雑誌 = The Hokkaido journal of surgery / 北海道外科雑誌編集委員会 編 ( 北海道外科学会 )  65 ( 2 ) 186 - 188  2020.12

  CiNii

• 【ロボット支援下肺葉切除術】

  宮島 正博, 槙 龍之輔, 高橋 有毅, 多田 周, 鶴田 航大, 新井 航, 進藤 悠真, 渡辺 敦

  北海道外科雑誌 ( 北海道外科学会 )  65 ( 1 ) 14 - 17  2020.06

  　View Summary

  2018年4月からロボット支援下手術の保険適用が広がり、呼吸器外科領域においても適用され、ロボット支援下手術件数が急速に増加している。肺癌に対するロボット支援下手術は死亡率、合併症率、在院日数において開胸手術よりも良好で、VATSとほぼ同等であったとの報告が認められるがロボット手術ならではの問題点も報告されている。論文ではロボット支援下肺葉切除術の最近の話題を提供する。(著者抄録)

• 教室における呼吸器外科ロボット支援手術の取り組み

  渡辺 敦, 宮島 正博, 槙 龍之輔, 高橋 有毅, 多田 周, 鶴田 航大, 新井 航

  気管支学 ( (NPO)日本呼吸器内視鏡学会 )  42 ( Suppl. ) S193 - S193  2020.06

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• Development of a selective culture method for pulmonary epithelial stem cells using high-performance immunotoxin

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2018.04

  -

  2021.03

   

  Yamaguchi Miki

  　View Summary

  In the respiratory field, idiopathic pulmonary fibrosis or chronic obstructive pulmonary disease is a chronic progressive disease with a poor prognosis for which no cure has been established. We thought that if the lung epithelial stem cells that make up the lung could be transplanted, it could be a new therapeutic method, and devised a selective culture using immunotoxin. By adding CD90-DT3C (immunotoxin), lung epithelial precursors / stem cells could be selectively cultured. In addition, the culture efficiency was further improved by culturing with the addition of A83-01 and Y27632. From the above, selective culture using immunotoxin was completed. We will proceed with the development of a treatment method for chronic obstructive pulmonary disease using this culture system.

• Characterization of distal airway stem-like cells expressing N-terminally truncated p63 and thyroid transcription factor-1 in the human lung

  Grant-in-Aid for Young Scientists (B)

  Project Year :

  2017.04

  -

  2019.03

   

  Tanaka Yusuke, HIRAI sachie, YAMAGUCHI miki, SUMI toshiyuki, TADA makoto, SAITO atsushi, CHIBA hirofumi, KOJIMA takashi, WATANABE atsushi, TAKAHASHI hiroki, SAKUMA yuji

  　View Summary

  We found that human lung epithelial (HuL) cells, derived from normal, peripheral lung tissue, in monolayer, mostly express both the N-terminally truncated isoform of p63 (delta Np63), a marker for airway basal cells, and thyroid transcription factor-1 (TTF-1), a marker for alveolar epithelial cells, even though these two molecules are usually expressed in a mutually ex- clusive way. Three-dimensionally cultured HuL cells differentiated to form bronchiole-like and alveolus-like organoids. We also uncovered a few bronchiolar epithelial cells expressing both delta Np63 and TTF-1 in the human lung, suggesting that these cells are the cells of origin for HuL cells. Taken together, delta Np63+ TTF-1+ peripheral airway epithelial cells are possibly the human counterpart of mouse DASCs and may offer potential for future regenerative medicine.

• Basic examination of survivin as therapeutic targets in KRAS-mutant lung adenocarcinoma

  Grant-in-Aid for Young Scientists (B)

  Project Year :

  2016.04

  -

  2018.03

   

  SUMI Toshiyuki, HIRAI sachie, YAMAGUCHI miki, TANAKA yusuke, TADA makoto, YAMADA gen, HASEGAWA tadashi, MIYAGI yohei, NIKI toshiro, WATANABE atsushi, TAKAHASHI hiroki, SAKUMA yuji

  　View Summary

  Survivin is highly expressed in the majority of malignant tumors. However, little is known about the roles of survivin in KRAS-mutant lung adenocarcinomas. In the present study, we examined 28 KRAS-mutant lung adenocarcinoma tissues and two KRAS-mutant lung adenocarcinoma cell lines, H358 and H441, in order to elucidate the potential of survivin as a therapeutic target. Patients with tumors immunohistochemically positive for survivin (n=18) had poorer outcomes than those with survivin-negative tumors (n=10). In the H358 and H441 cells, survivin knockdown alone induced senescence, not apoptosis. However, the H358 cells and H441 cells in which survivin was silenced, underwent significant apoptosis following combined treatment with ABT-263, a Bcl-2 inhibitor, and trametinib, a MEK inhibitor. Importantly, the triple combination of survivin knockdown with ABT-263 and trametinib treatment, clearly induced cell deathin an in vivo tumor xenograft model.