Education 【 display / non-display 】

Education 【 display / non-display 】

• 2007

  -

  2011

  Wakayama Medical University   Wakayama Medical University   Rehabilitation medicine  

• 1999

  -

  2005

  Wakayama Medical University   医学部  

Research Experience 【 display / non-display 】

Research Experience 【 display / non-display 】

• 2023.04

  -

  Now

  Yokohama City University School of Medicine   Rehabilitation Medicine   Associate Professor

  MD, PhD

• 2017.12

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  2022.03

  Wakayama Medical University   Rehabilitation medicine   Lecturer

  MD, PhD

Professional Memberships 【 display / non-display 】

Professional Memberships 【 display / non-display 】

• 2017.10

  -

  Now

  日本急性期リハビリテーション医学会

• 2009

  　

  　

  日本脊髄障害医学会

• 2007.06

  -

  Now

  日本リハビリテーション医学会

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Life sciences   Rehabilitation science  

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

• heat stress

• myokine

• stroke

• リハビリテーション医学

• exercise therapy

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Papers 【 display / non-display 】

Papers 【 display / non-display 】

• Observations of cold-induced vasodilation in persons with spinal cord injuries.

  Yasuhisa Fujita, Yoshi-Ichiro Kamijo, Tokio Kinoshita, Takamasa Hashizaki, Kouta Murai, Tatsuya Yoshikawa, Yasunori Umemoto, Chikako Kaminaka, Manabu Shibasaki, Fumihiro Tajima, Yukihide Nishimura

  Spinal cord    2024.02  [International journal]

  　View Summary

  STUDY DESIGN: Acute experimental study. OBJECTIVES: Cold-induced vasodilation is a local mechanism of protection against frostbite in non-injured persons. We assessed whether an increase in skin blood flow (SkBF) during local cooling (LC) was observed in individuals with spinal cord injuries (SCIs) and if the response patterns differed between region levels or sites. SETTING: Laboratory of Wakayama Medical University and the affiliated clinics, Japan. METHODS: A local cooler device (diameter 4 cm) was placed on the chest (sensate) and right thigh (non-sensate) in persons with cervical (SCIC; n = 9) and thoracolumbar SCIs (SCITL; n = 9). After the surface temperature under the device was controlled at 33 °C for 10 min (baseline), LC (-0.045 °C/s) was applied and the skin temperature was maintained at 15 and 8 °C for 15 min of each stage. SkBF (laser Doppler flowmetry) was monitored using a 1-mm needle-type probe inserted into its center. RESULTS: The percent change in SkBF (%ΔSkBF) on the chest remained unchanged until the end of 15 °C stage; thereafter, it increased to a level at least 70% greater than the baseline during the 8 °C stage in both groups. The %ΔSkBF on the thigh in both SCIC and SCITL notably increased from 8 and 6 min respectively, during the 8°C stage, compared to 1 min before the stage; however, it did not exceed the baseline level. CONCLUSIONS: An increase in SkBF during LC was observed both in the sensate and non-sensate areas in SCIs, although the magnitude was larger in the sensate area.

  DOI PubMed

• Increase in Serum Interleukin-1 Receptor Antagonist (IL-1ra) Levels after Wheelchair Half Marathon Race in Male Athletes with Spinal Cord Injury.

  Masumi Nakahama-Matsushima, Yoshi-Ichiro Kamijyo, Yasunori Umemoto, Takamasa Hashizaki, Yukihide Nishimura, Kazunari Furusawa, Yohei Furotani, Fumihiro Tajima, Ken Kouda

  Journal of clinical medicine   12 ( 22 )  2023.11  [International journal]

  　View Summary

  Exercise increases the serum level of interleukin-6 (IL-6), which in turn stimulates the production of various inflammatory cytokine antagonists, such as interleukin-1 receptor antagonist (IL-1ra). Individuals with cervical spinal cord injury (CSCI) are at high risk of inflammatory conditions. This study compared the effects of wheelchair half marathon on the immune system of male athletes with CSCI and those with thoracic/lumber spinal cord injury (SCI). Neutrophil count, IL-1ra, IL-6, and various endocrine parameters were measured before, immediately and 1 h after the race in five CSCI and six SCI who completed the wheelchair marathon race. The percentage of neutrophils was significantly higher in CSCI immediately and 1 h after the race, compared with the baseline, and significantly higher in SCI at 1 h after the race. IL-6 was significantly higher immediately and 1 h after the race in SCI, whereas no such changes were noted in IL-6 in CSCI. IL-1ra was significantly higher at 1 h after the race in both SCI and CSCI. The race was associated with an increase in IL-1ra in both CSCI and SCI. These findings suggest wheelchair half marathon race increases IL-1ra even under stable IL-6 status in male CSCI individuals, and that such post-race increase in IL-1ra is probably mediated through circulatory neutrophils.

  DOI PubMed

• Effects of continuous bicycle ergometer and step exercises from admission to discharge in a patient with myelodysplastic syndrome undergoing myeloablative conditioning and hematopoietic stem cell transplantation: A case report.

  Makoto Kawanishi, Yukihide Nishimura, Tokio Kinoshita, Takamasa Hashizaki, Yasunori Umemoto, Kazunari Nishiyama, Fumihiro Tajima

  Medicine   102 ( 24 ) e34001  2023.06  [International journal]

  　View Summary

  BACKGROUND: In myelodysplastic syndromes (MDS), in addition to disease-related symptoms, many adverse events are associated with anticancer agents, myeloablative conditioning (MAC), and allogeneic hematopoietic stem cell transplantation (allo-HSCT). Isolation and bed rest in a clean room severely limit physical activity, resulting in cardiopulmonary and muscle weakness. In addition, post-transplant patients may experience general fatigue, gastrointestinal symptoms, and infections associated with a weakened immune system, as well as graft-versus-host disease, which causes further decline in physical function and activities of daily living (ADL). Most reports on the rehabilitation of patients with hematopoietic tumors involve interventions before and after chemotherapy or transplantation. However, an important issue is to establish effective and feasible exercise programs in a clean room setting, where activity is severely limited and physical function is most likely to decline. CASE REPORT: This case report describes the treatment progress of a 60-year-old man with MDS and thrombocytopenia scheduled to receive MAC and allo-HSCT, who continued bicycle ergometer and step exercises from admission to discharge. The patient was admitted for allo-HSCT, and on day 4, he started bicycle ergometer and step exercise in a clean room and continued until discharge. As a result, exercise tolerance and lower-extremity muscle strength were maintained at the time of hospital discharge. Furthermore, the patient was able to continue rehabilitation in a restricted environment without adverse events. CONCLUSIONS: The rehabilitation and treatment course of this case may provide valuable information for patients with MDS and thrombocytopenia.

  DOI PubMed

• Feasibility of Seated Stepping and Handshaking as a Cardiopulmonary Exercise Testing: A Pilot Study.

  Kyosuke Imashiro, Yasuko Nishioka, Kenzo Teramura, Hiromi Hashimoto, Hiroki Kimura, Naoya Tanabe, Yasuhiro Taniguchi, Koya Nakai, Yasunori Umemoto, Tomoyuki Ito, Fumihiro Tajima, Yasuo Mikami

  Journal of clinical medicine   12 ( 6 )  2023.03  [International journal]

  　View Summary

  Cardiopulmonary function is usually assessed by cardiopulmonary exercise testing (CPX) using a cycle ergometer (CE-CPX) or a treadmill, which is difficult in patients with lower extremity motor dysfunction. A stepping and handshaking (SHS) exercise has been developed that can be performed safely and easily while sitting on a chair. This study compared peak oxygen uptake (peak V.O2) between CE-CPX and SHS-CPX in healthy adults and investigated the safety and validity of SHS-CPX. Twenty young adults (mean age 27.8 ± 4.4 years) were randomly assigned to perform CE-CPX or SHS-CPX, with the other test to follow 1-2 weeks later. The peak V.O2, respiratory exchange ratio (RER), peak heart rate, blood pressure, and test completion time were compared between CE-CPX and SHS-CPX. All subjects completed the examination and met the criteria for peak V.O2. SHS-CPX and CE-CPX showed a strong correlation with peak V.O2 (r = 0.85, p < 0.0001). The peak V.O2 (40.4 ± 11.3 mL/min/kg vs. 28.9 ± 8.0 mL/min/kg), peak heart rate (190.6 ± 8.9 bpm vs. 172.1 ± 12.6 bpm), and test completion time (1052.8 ± 143.7 s vs. 609.1 ± 96.2 s) were significantly lower in the SHS-CPX (p < 0.0001). There were no adverse events. The peak V.O2 with SHS-CPX was equivalent to about 70% of that with CE-CPX despite the exercise being performed in a sitting position, suggesting its suitability as a submaximal exercise test.

  DOI PubMed

• Quantification of catecholamine neurotransmitters released from cutaneous vasoconstrictor nerve endings in men with cervical spinal cord injury.

  Tomonori Nakata, Manabu Shibasaki, Yukihide Nishimura, Tokio Kinoshita, Takamasa Hashizaki, Yoshi-Ichiro Kamijo, Ken Kouda, Yasunori Umemoto, Fumihiro Tajima

  American journal of physiology. Regulatory, integrative and comparative physiology   324 ( 3 ) R345-R352  2023.03  [International journal]

  　View Summary

  Control of cutaneous circulation is critically important to maintain thermoregulation, especially in individuals with cervical spinal cord injury (CSCI) who have no or less central thermoregulatory drive. However, the peripheral vasoconstrictor mechanism and capability have not been fully investigated after CSCI. Post- and presynaptic sensitivities of the cutaneous vasoconstrictor system were investigated in 8 CSCI and 7 sedentary able-bodied (AB) men using an intradermal microdialysis technique. Eight doses of norepinephrine (NE, 10-8 to 10-1 M) and five doses of tyramine (TY, 10-8, 10-5 to 10-2 M) were administered into the anterior right and left thigh, respectively. Endogenous catecholamines, noradrenaline, and dopamine, collected at the TY site, were determined by high-performance liquid chromatography with electrochemical detection. Regardless of vasoconstrictor agents, cutaneous vascular conductance decreased dose-dependently and responsiveness was similar between the groups (NE: Group P = 0.255, Dose P = 0.014; TY: Group P = 0.468, Dose P < 0.001), whereas the highest dose of each drug induced cutaneous vasodilation. Administration of TY promoted the release of noradrenaline and dopamine in both groups. Notably, the amount of noradrenaline released was similar between the groups (P = 0.819), although the concentration of dopamine was significantly greater in individuals with CSCI than in AB individuals (P = 0.004). These results suggest that both vasoconstrictor responsiveness and neural functions are maintained after CSCI, and dopamine in the skin is likely to induce cutaneous vasodilation.

  DOI PubMed

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Books and Other Publications 【 display / non-display 】

Books and Other Publications 【 display / non-display 】

• 耳鼻咽喉科頭頸部外科領域のリハビリテーション医学・医療テキスト

  久保, 俊一, 村上, 信五, 日本リハビリテーション医学教育推進機構, 日本耳鼻咽喉科頭頸部外科学会, 日本言語聴覚士協会, 日本理学療法士協会, 日本リハビリテーション医学会, 土井, 勝美, 徳永, 大作

  日本リハビリテーション医学教育推進機構  2022.06 ISBN: 9784991177613

• リハビリテーション医学・医療における栄養管理テキスト

  久保, 俊一, 吉村, 芳弘, 角田, 亘, 百崎, 良, 徳永, 大作, 日本リハビリテーション医学教育推進機構, 日本リハビリテーション医学会

  医学書院  2022.04 ISBN: 9784260047395

• リハビリテーション医学・医療コアテキスト

  久保, 俊一, 角田, 亘, 佐浦, 隆一, 三上, 靖夫, 徳永, 大作, 日本リハビリテーション医学教育推進機構, 日本リハビリテーション医学会

  医学書院  2022.03 ISBN: 9784260049597

• 内部障害のリハビリテーション医学・医療テキスト

  久保, 俊一, 海老原, 覚, 上月, 正博, 牧田, 茂, 伊藤, 修 (循環器病学), 角田, 亘, 徳永, 大作, 日本リハビリテーション医学教育推進機構, 日本リハビリテーション医学会

  医学書院  2022.03 ISBN: 9784260045919

• 総合力がつくリハビリテーション医学・医療テキスト

  久保, 俊一, 田島, 文博, 日本リハビリテーション医学教育推進機構, 日本リハビリテーション病院・施設協会, 日本慢性期医療協会, 日本理学療法士協会, 日本作業療法士協会, 日本言語聴覚士協会, 日本義肢装具士協会, 日本リハビリテーション医学会, 安保, 雅博, 徳永, 大作

  日本リハビリテーション医学教育推進機構  2021.02 ISBN: 9784991177606

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Misc 【 display / non-display 】

Misc 【 display / non-display 】

• 慢性期脳卒中患者へのステップ運動とFESの併用即時効果の検討

  梅本 安則, 上田 幸輝, 持田 賢志, 上條 義一郎, 田島 文博

  日本生体電気・物理刺激研究会誌 ( 日本生体電気・物理刺激研究会 )  36   32 - 32  2023.11

• ハイケアユニットにおける早期離床・リハビリテーション加算の導入効果

  佐伯 拓也, 山内 裕子, 原木 望, 立花 佳枝, 梅本 安則, 中村 健

  The Japanese Journal of Rehabilitation Medicine ( (公社)日本リハビリテーション医学会 )  60 ( 秋季特別号 ) S366 - S366  2023.10

• 脊髄損傷者のリハビリテーション医療

  梅本 安則

  The Japanese Journal of Rehabilitation Medicine ( (公社)日本リハビリテーション医学会 )  60 ( 秋季特別号 ) S162 - S162  2023.10

• β遮断薬を使用している開胸術後患者における酸素飽和度閾値(ST)と嫌気性代謝閾値(AT)との一致性の検討

  折津 英幸, 梅本 安則, 佐伯 拓也, 原木 望, 織間 良介, 古井 心子, 稗田 保奈美, 立花 佳枝, 山内 裕子, 中村 健

  The Japanese Journal of Rehabilitation Medicine ( (公社)日本リハビリテーション医学会 )  60 ( 秋季特別号 ) S460 - S460  2023.10

• 手術適応のある消化器癌患者の術前Phase angleと身体機能・筋力・筋量の関連

  織間 良介, 原木 望, 梅本 安則, 山内 裕子, 立花 佳枝, 稗田 保奈美, 古井 心子, 佐伯 拓也, 野々垣 学, 中村 健

  The Japanese Journal of Rehabilitation Medicine ( (公社)日本リハビリテーション医学会 )  60 ( 秋季特別号 ) S355 - S355  2023.10

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Research Projects 【 display / non-display 】

Research Projects 【 display / non-display 】

• Sports injury in upper limbs of wheelchair athletes

  Grant-in-Aid for Scientific Research (C)

  Project Year :

  2015.04

  -

  2018.03

   

  MITSUI Toshihito

  　View Summary

  In this study, we investigated the actual condition of shoulder joint sports injury by physiological findings and image diagnosis, etc., for the athlete of handicapped persons with spinal cord injury under wheelchair athletics. In addition, we examined the content and amount of practice and analyzed the form of each player. We examined the results comprehensively, examined the mechanism of the occurrence of shoulder joint sports injury, and examined the preventive method. . As a survey item, we extracted all factors that could affect the shoulder joints of wheelchair players. Specifically, 1. Practice content, 2. Practice amount, 3. Wheelchair drive form, 4. Physical findings, 5. Image findings (echo and MRI) were investigated.

• 大腿骨頚部骨折術後患者のリハビリテーションにおける至適栄養量に関する研究

  若手研究(B)

  Project Year :

  2015.04

  -

  2017.03

   

  梅本 安則

  　View Summary

  高齢大腿骨頚部骨折患者の術後の安静時代謝量を検討する為に、高齢大腿骨頸部骨折術後患者９名の関西電力病院回復期リハビリ病棟入院時の呼気ガス分析装置による安静時代謝量測定、Harris-benedictの計算式による推定エネルギー量を測定し比較分析した。また、窒素出納を検討する為、24時間蓄尿検査による蛋白排泄量を測定した。 入院時の安静時代謝量測定による体重当たりの実際必要エネルギー量は23.9±2.7kcal/kgであった。また、計算式による推定エネルギー量は16.7±1.0kcal/kgであった。安静時代謝量は計算式より算出した推定エネルギー量である基礎代謝量に1.2を乗したものであるため、今回計算した推定エネルギー量を補正し、実際に測定した安静時代謝量と比較した。統計学的な比較上、今回測定した安静時代謝量は計算された推定エネルギー量の補正値より有意に高い値であった。 また、入院時の尿からの１日蛋白排泄量は0.6±0.3g/kg/dayであった。これは、尿以外の窒素喪失を考慮に入れれば、窒素平衡に必要と考えられている0.68g/kg/dayの蛋白摂取量では、窒素平衡が負になると考えられる。これらの入院時安静時代謝量と窒素排泄量から、元来推定される基礎代謝量と蛋白摂取量から計算された栄養摂取では、低栄養・骨格筋量が進行する可能性がある事が示唆された。 主研究者が海外留学のため、上記の安静時代謝量と蛋白排泄量を基にした栄養設定群における運動療法経過中の２週間毎の骨格筋量、安静時代謝量、血清栄養指標、窒素排泄量、運動機能の経時的変化を測定する事ができなかった為、今後行なっていく必要がある。

Committee Memberships 【 display / non-display 】

Committee Memberships 【 display / non-display 】

• 2019

  -

  Now

    代議員

• 2019

  -

  Now

    代議員