Updated on 2026/04/24

写真a

 
OTSUKA Noriyuki
 
Organization
School of Medicine Department of Clinical Pathology Associate Professor
Title
Associate Professor
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Degree

  • PhD ( 北海道大学 )

  • MD ( 北海道大学 )

Research Interests

  • POF

  • CGG repeat

  • 三塩基リピート病

  • Fragile X症候群

  • 卵巣

  • 活性化リガンド

  • NKG2D

  • ナチュラルキラー細胞

  • MHC

  • がん

  • 皮膚免疫

  • 免疫監視

Research Areas

  • Life Science / Experimental pathology

  • Life Science / Human pathology

Research History

  • Hokkaido University Hospital   Department of surgical pathology

    2022.4

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  • 北海道大学 医学(系)研究科(研究院)   助教

    2012

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Papers

  • NKG2D Ligand Expression Induced by Oxidative Stress Mitigates Cutaneous Ischemia-Reperfusion Injury. International journal

    Keishi Makita, Noriyuki Otsuka, Utano Tomaru, Koji Taniguchi, Masanori Kasahara

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society   71 ( 2 )   61 - 72   2023.2

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    Pressure ulcers represent a crucial clinical problem, especially in hospitalized patients. Ischemia-reperfusion (I-R) is an important cause of these lesions. Natural killer (NK), invariant NK T (iNKT), and dendritic epidermal T-cells, which express the natural killer group 2, member D (NKG2D) receptor, have been reported to have physiological roles in skin tissue repair and wound healing. However, a role for NKG2D-NKG2D ligand interactions in I-R-induced skin injury has not been determined. Using a murine pressure ulcer model, we demonstrated that I-R-induced ulcers in NKG2D-deficient mice were larger than those in wild-type or T-cell receptor δ knockout mice. Histopathological evaluation revealed that accumulation of macrophages and neutrophils at the peripheral deep dermis and subcutaneous tissue of the ulcers was enhanced in NKG2D-deficient mice. Rae-1 mRNA, which encodes an NKG2D ligand, was induced, and RAE-1 protein was detected immunohistochemically in fibroblasts and inflammatory cells in the dermis after reperfusion. RAE-1 expression was also increased in primary mouse fibroblasts treated with sodium arsenite. These results suggested that NKG2D ligand expression was induced by oxidative stress after I-R injury and support a putative role for this ligand in wound repair. Furthermore, the influx of NKG2D-positive cells at I-R sites may mitigate pressure ulcers via NKG2D-NKG2D ligand interactions.

    DOI： 10.1369/00221554221147582

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  • P450 Side-Chain Cleavage Enzyme (P450-SCC) Is an Ovarian Autoantigen in a Mouse Model for Autoimmune Oophoritis. International journal

    Zhi-Bin Tong, Noriyuki Otsuka, Wei Tu, Qingxiang Wei, Alan H DeCherney

    Reproductive sciences (Thousand Oaks, Calif.)   29 ( 8 )   2391 - 2400   2022.8

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    Steroid-producing cells contain key cytochrome P450 enzymes, such as side-chain cleavage (P450-SCC) and 17α-hydroxylase (17α-OH). They are required for steroid hormone synthesis and considered antigens associated with Addison's disease and autoimmune primary ovarian insufficiency (POI). We studied an animal model for human autoimmune POI in mice with autoimmune oophoritis induced by neonatal thymectomy performed at day 3 (TX3). We previously identified an oocyte-specific protein as a major antigen inciting autoimmune oophoritis in mice. In this study, we characterized ovarian steroid-producing cell antigens. Using indirect immunofluorescence staining, we tested immune reactions in mouse ovarian and adrenal tissue sections with sera from TX3 female mice. More than half of the TX3 mice (8 of 15) produced antibodies reacting with both ovarian and adrenal steroid-producing cells, including some that reacted to oocytes as well. We produced recombinant proteins for the three key steroidogenic enzymes 17α-OH, P450-SSC, and 3β-hydroxysteroid dehydrogenase (3β-HSD) and tested their immune reactions with individual mouse sera. By immunoblotting, all mouse sera that reacted with the steroid-producing cells (n = 8) were shown to react with the P450-SCC, but not with the 17α-OH or 3β-HSD recombinant proteins. The sham-operated mouse sera and TX3 mouse sera negative for steroid-producing cells did not react with the P450-SCC recombinant protein. Our findings indicate that the P450-SCC is a specific and unique major antigen within the ovarian steroid-producing cells. Given their similarity of predicted antigenicity, we assume that P450-SCC acts in human autoimmune POI as it does in mouse autoimmune oophoritis.

    DOI： 10.1007/s43032-022-00970-7

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  • Case Report: Hereditary Fibrosing Poikiloderma With Tendon Contractures, Myopathy, and Pulmonary Fibrosis (POIKTMP) Presenting With Liver Cirrhosis and Steroid-Responsive Interstitial Pneumonia

    Michiko Takimoto-Sato, Toshinari Miyauchi, Masaru Suzuki, Hideyuki Ujiie, Toshifumi Nomura, Tomoo Ikari, Tomohiko Nakamura, Kei Takahashi, Machiko Matsumoto-Sasaki, Hirokazu Kimura, Hiroki Kimura, Yuichiro Matsui, Takashi Kitagataya, Ren Yamada, Kazuharu Suzuki, Akihisa Nakamura, Masato Nakai, Takuya Sho, Koji Ogawa, Naoya Sakamoto, Naoko Yamaguchi, Noriyuki Otsuka, Utano Tomaru, Satoshi Konno

    Frontiers in Genetics   13   2022.5

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    Background: Hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis (POIKTMP) is an extremely rare disease caused by mutations in FAM111B, and only approximately 30 cases have been reported worldwide. Some patients develop interstitial pneumonia, which may lead to progressive pulmonary fibrosis and poor prognosis. However, no effective treatment for interstitial pneumonia associated with POIKTMP has been reported. Here, we report an autopsy case of POIKTMP, wherein interstitial pneumonia was improved by corticosteroids.

    Case Presentation: A 44-year-old Japanese man was referred to our hospital due to poikiloderma, hypotrichosis, and interstitial pneumonia. He developed progressive poikiloderma and muscle weakness since infancy. He also had tendon contractures, short stature, liver cirrhosis, and interstitial pneumonia. Mutation analysis of FAM111B revealed a novel and de novo heterozygous missense mutation, c.1886T > G (p(Phe629Cys)), through which we were able to diagnose the patient with POIKTMP. 3 years after the POIKTMP diagnosis, interstitial pneumonia had worsened. After 2 weeks of administrating 40 mg/day of prednisolone, his symptoms and lung shadows improved. However, he subsequently developed severe hepatic encephalopathy and eventually died of respiratory failure due to bacterial pneumonia and pulmonary edema. Autopsy revealed an unclassifiable pattern of interstitial pneumonia, as well as the presence of fibrosis and fatty degeneration in several organs, including the liver, kidney, skeletal muscle, heart, pancreas, and thyroid.

    Conclusions: We report a case of POIKTMP in which interstitial pneumonia was improved by corticosteroids, suggesting that corticosteroids could be an option for the treatment of interstitial pneumonia associated with this disease.

    DOI： 10.3389/fgene.2022.870192

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  • A rare case of cavernous hemangioma accompanied with diffuse hepatic hemangiomatosis. International journal

    Takuji Ota, Toshiya Kamiyama, Takuya Kato, Takayuki Hanamoto, Kunihiro Hirose, Noriyuki Otsuka, Shinichi Matsuoka, Akinobu Taketomi

    Surgical case reports   6 ( 1 )   251 - 251   2020.10

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    BACKGROUND: Hepatic cavernous hemangioma (CH) is the most common hepatic benign tumor. Most cases are solitary, asymptomatic, and found incidentally. In symptomatic cases with rapidly growing tumors and coagulopathy, surgical treatment is considered. In rare cases, diffuse hepatic hemangiomatosis (DHH) is reported as a comorbidity. The etiology of DHH is unknown. CASE PRESENTATION: A 29-year-old female patient had a history of endometriosis treated with oral contraceptives. Hepatic CH was incidentally detected in the segment IVa of the liver according to the Couinaud classification. Follow-up computed tomography (CT) and ultrasound sonography showed the growth of the lesion and formation of multiple new lesions near the first. Enhanced CT and magnetic resonance imaging (MRI) revealed that the new lesions were different from CH. Although oral contraceptives were stopped, all lesions grew in size. Malignancy and possibility of rupture of these tumors were considered due to the clinical course, and we opted for surgical removal of the tumors. Left liver lobectomy and cholecystectomy were performed. Surgical findings were small red spot spreading and a mass in segment IV of the liver. Pathological examination revealed a circumscribed sponge-like tumor with diffuse irregular extension to the adjacent area. Both of the lesions consisted of blood-filled dilated vascular spaces lined by flat endothelium without atypia. The diagnosis was hepatic CH with DHH. The patient was discharged on postoperative day 12 uneventfully. CONCLUSION: We report the successful resection of CH with DHH. The case findings suggest a relationship between oral contraceptive use and enlargement of CH and DHH. Although DHH has been poorly understood, a few previously published cases reported DHH occurrence in patients using oral contraceptives. In such cases, the decision to perform surgical resection should be made after careful examination.

    DOI： 10.1186/s40792-020-01023-4

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  • Expression of the immunoproteasome subunit β5i in non-small cell lung carcinomas. International journal

    Takayuki Kiuchi, Utano Tomaru, Akihiro Ishizu, Makoto Imagawa, Sari Iwasaki, Akira Suzuki, Noriyuki Otsuka, Yoshihito Ohhara, Ichiro Kinoshita, Yoshihiro Matsuno, Hirotoshi Dosaka-Akita, Masanori Kasahara

    Journal of clinical pathology   74 ( 5 )   300 - 306   2020.9

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    AIM: The immunoproteasome is a specific proteasome isoform whose proteolytic activity enhances the generation of antigenic peptides to be presented by major histocompatibility complex class I molecules to CD8+ T cells. Physiologically, it is expressed abundantly in immune cells and is induced in somatic cells by cytokines, especially interferon-γ. Recently, variable expression of immunoproteasomes has been demonstrated in different types of cancers. However, the clinical significance of immunoproteasome expression in malignant tumours is poorly understood. In this study, we performed clinicopathological evaluation of immunoproteasome subunit β5i in non-small cell lung carcinomas (NSCLCs). METHODS: Tumour tissues were collected from 155 patients with NSCLCs, and immunohistochemical analysis for β5i was performed in relation to the prognosis of patients. RESULTS: High expression of β5i was found in about 20% of all NSCLCs and was found significantly more frequently (40%) in the adenocarcinoma subset. High expression of β5i was associated with a better 5-year relative survival rate in patients with pStage I to II adenocarcinoma and was also a significant and independent favourable prognostic factor in adenocarcinoma patients. In addition, when we performed in vitro analysis using NSCLC cell lines, combined treatment with the immunoproteasome-specific inhibitor ONX0914 and the proteasome inhibitor MG132 enhanced cell death in β5i-expressing NSCLC cell lines. CONCLUSION: The expression of immunoproteasome can be explored as both a prognostic factor and a potential therapeutic target in NSCLCs. Since immunoproteasomes have crucial role in the antigen presentation, further studies may help to provide essential knowledge for therapeutic strategies in anticancer immunotherapy.

    DOI： 10.1136/jclinpath-2020-206618

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  • Expression of cathepsins B, D and K in thymic epithelial tumours. International journal

    Naoko Yamaguchi, Utano Tomaru, Takayuki Kiuchi, Akihiro Ishizu, Takahiro Deguchi, Noriyuki Otsuka, Satoshi Tanaka, Katsuji Marukawa, Yoshihiro Matsuno, Masanobu Kitagawa, Masanori Kasahara

    Journal of clinical pathology   74 ( 2 )   84 - 90   2020.5

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    AIM: Cathepsins are proteases that regulate a wide range of physiological processes, including protein turnover, cell signalling and antigen presentation. Recent studies have shown that cathepsins are highly upregulated in many types of tumours. Of the 15 cathepsins in humans, cathepsins V and S are abundantly expressed in the thymus, and we previously showed that the immunostaining of these cathepsins could serve as diagnostic markers for thymic epithelial tumours. However, little is known about the expression of other cathepsins in thymic epithelial tumours. To determine the diagnostic implications of cathepsins, we performed immunohistochemical analysis of cathepsin B (CTB), cathepsin D (CTD) and cathepsin K (CTK), all of which have been reported to correlate with the progression of squamous cell carcinoma. METHODS: The association between cathepsin expression and clinicopathological features was evaluated in 122 cases of thymoma and thymic carcinoma. RESULTS: CTB and CTD were frequently expressed in type A and type AB thymomas. In contrast, CTB and CTD were significantly less common in type B thymomas than in type A or AB thymomas. In type AB thymomas, the expression of CTB correlated with histological features, and was found predominantly in the type A component. Notably, CTK was expressed most commonly in thymic carcinomas, and patients who died of the disease showed increased expression of CTK. CONCLUSIONS: The expression of CTB and CTD correlated with the histological subtype of thymoma. In addition, the expression of CTK appears to be useful for the diagnosis of thymic carcinomas and as a prognostic marker.

    DOI： 10.1136/jclinpath-2020-206551

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  • Pulmonary capillary hemangiomatosis-predominant vasculopathy in a patient with rheumatoid arthritis-associated interstitial lung disease: An autopsy report. International journal

    Junichi Nakamura, Ichizo Tsujino, Gaku Yamamoto, Toshitaka Nakaya, Kei Takahashi, Hirokazu Kimura, Takahiro Sato, Taku Watanabe, Shimpei Nakagawa, Noriyuki Otsuka, Hiroshi Ohira, Satoshi Konno

    Respiratory medicine case reports   31   101215 - 101215   2020

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    Pulmonary capillary hemangiomatosis (PCH) is a rare cause of pulmonary hypertension (PH) associated with poor prognosis. Clinically, it is characterized by severe hypoxemia, centrilobular ground-glass opacities on computed tomography, and pulmonary congestion triggered by pulmonary vasodilating therapy. In some cases, PCH has been reported to develop with other disorders including connective tissue disease; however, to date, no reports have described PCH in a patient with rheumatoid arthritis. We report a case of a 59-year-old male PCH patient with rheumatoid arthritis and associated pulmonary fibrosis. He was initially diagnosed with severe group 3 PH and received sildenafil, which generated a favorable hemodynamic response. However, 5 years later, his pulmonary hemodynamics deteriorated, and he died at the age of 67. An autopsy was performed, and thickening of alveolar septa and capillary proliferation, pathological features of PCH, were extensively observed in both lungs. We discuss when PCH developed, how sildenafil improved his hemodynamics, and how PCH could be clinically detected by noninvasive evaluations.

    DOI： 10.1016/j.rmcr.2020.101215

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  • Laparoscopic posterior pelvic exenteration for primary adenocarcinoma of the rectovaginal septum without associated endometriosis: A case report. International journal

    Toshio Fujimoto, Fumie Tanuma, Noriyuki Otsuka, Soromon Kataoka

    Molecular and clinical oncology   10 ( 1 )   92 - 96   2019.1

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    The present report describes a case of laparoscopic posterior pelvic exenteration of a primary adenocarcinoma of the rectovaginal septum (PARS) without associated endometriosis. A 49-year-old woman was admitted to hospital for rectal bleeding. Imaging studies showed a 7-cm solid tumor located in the rectovaginal septum, presenting with invasion to the posterior aspect of the uterine cervix and the anterior rectal wall. The patient received laparoscopic posterior exenteration and rectosigmoid anastomosis followed by chemotherapy. There were no intra- or post-operative complications. Histopathological examination of the neoplastic tissue revealed moderate to severe cytological atypia with bizarre multinucleated cells and prominent mitotic figures. Histopathologically, R0 resection was achieved. No endometriotic lesions were confirmed in the primary tumor or other removed tissues. Immunohistochemistry showed positive staining for cytokeratin (CK)7, cancer antigen 125, vimentin, estrogen receptor and p53, but negative staining for CK20, progesterone receptor, p40 and thyroid transcription factor 1. Based on these findings and on the location of the tumor, the neoplasm was diagnosed as PARS without associated endometriosis, which may have arisen from metaplasia of the embryological Müllerian-duct remnants.

    DOI： 10.3892/mco.2018.1751

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  • Clinicopathological significance of PSF3 expression in uterine endometrial carcinomas. Reviewed International journal

    Jong Kun Park, Noriyuki Otsuka, Utano Tomaru, Hiroaki Suzuki, Manabu Azuma, Kazuhira Okamoto, Katsushige Yamashiro, Masanori Kasahara

    Human pathology   80   104 - 112   2018.10

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    PSF3 (Partner of SLD Five 3) is a member of the heterotetrameric complex termed GINS. Previous studies have shown that PSF3 is up-regulated in several cancers and is associated with tumor malignancy. However, the clinicopathological significance of PSF3 expression in endometrial lesions is still poorly understood. To investigate whether PSF3 could serve as a useful biomarker for endometrial carcinomas, we performed immunohistochemical analysis of PSF3 expression. In 155 cases of endometrial carcinomas (ECs), the mean tumor proportion score of PSF3 expression was 30.7% in G1 endometrioid carcinoma, 55.0% in G2 endometrioid carcinoma, 59.0% in G3 endometrioid carcinoma, and 58.9% in nonendometrioid carcinomas. In 25 cases of atypical hyperplasia, the mean tumor proportion score of PSF3 expression was significantly lower (10.4%). High expression of PSF3 was associated with more advanced pathologic T stage (P = .000), lymphatic invasion (P = .001), and poor clinical outcomes such as shorter relapse-free survival (P = .000) and overall survival (P = .001). When we compared the immunostaining of PSF3 and Ki-67, the proportions of PSF3-positive cells in tumor epithelial cells were comparable to those of Ki-67-positive cells. However, PSF3-positive cells were selectively found in tumor cells, whereas Ki-67-positive cells were also found in tumor stromal cells. These results demonstrated that PSF3 immunostaining was valuable as a histopathologic marker for differential diagnosis between atypical hyperplasia and ECs, for tumor histologic grading, and for determining a patient's prognosis. PSF3 may play a crucial role in tumor progression in EC.

    DOI： 10.1016/j.humpath.2018.06.010

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  • Expression of cathepsins V and S in thymic epithelial tumors. Reviewed International journal

    Shizuka Kiuchi, Utano Tomaru, Akihiro Ishizu, Makoto Imagawa, Takayuki Kiuchi, Sari Iwasaki, Akira Suzuki, Noriyuki Otsuka, Takahiro Deguchi, Tomohiro Shimizu, Katsuji Marukawa, Yoshihiro Matsuno, Masanori Kasahara

    Human pathology   60   66 - 74   2017.2

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    DOI： 10.1016/j.humpath.2016.09.027

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  • Decreased expression of thymus-specific proteasome subunit β5t in Down syndrome patients. Reviewed International journal

    Utano Tomaru, Takahiro Tsuji, Shizuka Kiuchi, Akihiro Ishizu, Akira Suzuki, Noriyuki Otsuka, Tomoki Ito, Hitoshi Ikeda, Yuichiro Fukasawa, Masanori Kasahara

    Histopathology   67 ( 2 )   235 - 44   2015.8

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    DOI： 10.1111/his.12642

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  • Fatal cardiac small-vessel involvement in ANCA-associated vasculitis: an autopsy case report Reviewed

    Sari Iwasaki, Akira Suzuki, Takashi Fujisawa, Taiju Sato, Shinya Shirai, Mitsunori Kamigaki, Noriyuki Otsuka, Utano Tomaru, Akihiro Ishizu

    CARDIOVASCULAR PATHOLOGY   24 ( 6 )   408 - 410   2015.7

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    DOI： 10.1016/j.carpath.2015.07.005

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  • Immunohistochemical validation and expression profiling of NKG2D ligands in a wide spectrum of human epithelial neoplasms. Reviewed International journal

    Hiromi Fujita, Yutaka Hatanaka, Yoichi Sutoh, Yuta Suzuki, Koji Oba, Kanako C Hatanaka, Tomoko Mitsuhashi, Noriyuki Otsuka, Kazunori Fugo, Masanori Kasahara, Yoshihiro Matsuno

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society   63 ( 3 )   217 - 27   2015.3

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    The MHC class I-chain-related proteins (MICs) and the UL16-binding proteins (ULBPs) are inducible stress response molecules that work as activators of a specific receptor, NKG2D, which is expressed on effector cells, such as NK cells and subsets of T cells. In this study, we sought to explore the biological significance of NKG2D ligands in human neoplasms by comprehensively examining the immunohistochemical expression profile of NKG2D ligands in a variety of human epithelial neoplasms. Following careful validation of the immunohistochemical specificity and availability of anti-human ULBP antibodies for formalin-fixed paraffin-embedded (FFPE) materials, the expression of NKG2D ligands was analyzed in FFPE tissue microarrays comprising 22 types of epithelial neoplastic tissue with their non-neoplastic counterpart from various organs. Hierarchical cluster analysis demonstrated a positive relationship among ULBP2/6, ULBP3, ULBP1, and ULBP5, whose expression patterns were similar across all of the neoplastic tissues examined. In contrast, MICA/B, as well as ULBP4, did not appear to be related to any other ligand. These expression profiles of NKG2D ligands in human neoplasms based on well-validated specific antibodies, followed by hierarchical cluster analysis, should help to clarify some functional aspects of these molecules in cancer biology, and also provide a path to the development of novel tumor-type-specific treatment strategies.

    DOI： 10.1369/0022155414563800

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  • The SKINT1-like gene is inactivated in hominoids but not in all primate species: implications for the origin of dendritic epidermal T cells. Reviewed International journal

    Rania Hassan Mohamed, Yoichi Sutoh, Yasushi Itoh, Noriyuki Otsuka, Yukiko Miyatake, Kazumasa Ogasawara, Masanori Kasahara

    PloS one   10 ( 4 )   e0123258   2015

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    DOI： 10.1371/journal.pone.0123258

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  • MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques. Reviewed International journal

    Shunji Ikeshita, Yukiko Miyatake, Noriyuki Otsuka, Masanori Kasahara

    Experimental and molecular pathology   97 ( 1 )   171 - 5   2014.8

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    DOI： 10.1016/j.yexmp.2014.07.002

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  • Possible linkage between microscopic polyangiitis and thrombosis via neutrophil extracellular traps Reviewed

    T. Imamoto, D. Nakazawa, H. Shida, A. Suzuki, N. Otsuka, U. Tomaru, A. Ishizu

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY   32 ( 1 )   149 - 150   2014.1

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  • Hepatosplenic gamma-delta T-cell lymphoma associated with Epstein-Barr virus. Reviewed

    Seiji Tsunematsu, Mitsuteru Natsuizaka, Hiromi Fujita, Noriyuki Otsuka, Katsumi Terashita, Fumiyuki Sato, Tomoe Kobayashi, Masato Nakai, Yoko Tsukuda, Hiromasa Horimoto, Takuya Sho, Goki Suda, Mitsuru Nakanishi, Satoshi Hashino, Makoto Chuma, Naoya Sakamoto

    Internal medicine (Tokyo, Japan)   53 ( 18 )   2079 - 82   2014

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    DOI： 10.2169/internalmedicine.53.2236

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  • Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency. Reviewed International journal

    Gloria E Hoffman, Wei Wei Le, Ali Entezam, Noriyuki Otsuka, Zhi-Bin Tong, Lawrence Nelson, Jodi A Flaws, John H McDonald, Sanjeeda Jafar, Karen Usdin

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society   60 ( 6 )   439 - 56   2012.6

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    DOI： 10.1369/0022155412441002

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  • Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair. Reviewed International journal

    Shigeru Yoshida, Rania Hassan Mohamed, Mizuho Kajikawa, Jun Koizumi, Minami Tanaka, Kazunori Fugo, Noriyuki Otsuka, Katsumi Maenaka, Hideo Yagita, Hitoshi Chiba, Masanori Kasahara

    Journal of immunology (Baltimore, Md. : 1950)   188 ( 8 )   3972 - 9   2012.4

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    DOI： 10.4049/jimmunol.1102886

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  • Blockade of interaction between NKG2D and an NKG2D ligand H60c delays wound repair Reviewed

    Yoshida S, Mohamed RH, Kajikawa M, Koizumi J, Tanaka M, Fugo K, Otsuka N, Maenaka K, Yagita H, Chiba H, Kasahara M

    Journal of Immunology   188 ( 8 )   3972 - 3979   2012.4

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    DOI： 10.4049/jimmunol.1102886

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  • Right atrial late gadolinium enhancement on cardiac magnetic resonance imaging in pulmonary hypertension. Reviewed

    Takahiro Sato, Ichizo Tsujino, Hiroshi Ohira, Noriko Oyama-Manabe, Yosuke Yamada, Noriyuki Otsuka, Masaharu Nishimura

    Circulation journal : official journal of the Japanese Circulation Society   76 ( 1 )   238 - 9   2012

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    DOI： 10.1253/circj.CJ-11-0585

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  • Autoimmune oophoritis with multiple molecular targets mitigated by transgenic expression of mater. Reviewed International journal

    Noriyuki Otsuka, Zhi-Bin Tong, Konstantina Vanevski, Wei Tu, Mickie H Cheng, Lawrence M Nelson

    Endocrinology   152 ( 6 )   2465 - 73   2011.6

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    DOI： 10.1210/en.2011-0022

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  • Complexity of tumor vasculature and molecular targeting therapies. Reviewed International journal

    Mitsuko Furuya, Kiyotaka Nagahama, Akihiro Ishizu, Noriyuki Otsuka, Yoji Nagashima, Ichiro Aoki

    Frontiers in bioscience (Elite edition)   3 ( 2 )   549 - 61   2011.1

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  • The incidence and mechanism of sunitinib-induced thyroid atrophy in patients with metastatic renal cell carcinoma Reviewed

    N. Shinohara, M. Takahashi, T. Kamishima, H. Ikushima, N. Otsuka, A. Ishizu, C. Shimizu, H. Kanayama, K. Nonomura

    BRITISH JOURNAL OF CANCER   104 ( 2 )   241 - 247   2011.1

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    DOI： 10.1038/sj.bjc.6606029

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  • Identification of a third variable lymphocyte receptor in the lamprey. Reviewed International journal

    Jun Kasamatsu, Yoichi Sutoh, Kazunori Fugo, Noriyuki Otsuka, Kazuya Iwabuchi, Masanori Kasahara

    Proceedings of the National Academy of Sciences of the United States of America   107 ( 32 )   14304 - 8   2010.8

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    DOI： 10.1073/pnas.1001910107

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  • Images in cardiovascular medicine: Imaging of cardiac sarcoid lesions using fasting cardiac 18F-fluorodeoxyglucose positron emission tomography: an autopsy case. Reviewed International journal

    Hiroaki Koiwa, Ichizo Tsujino, Hiroshi Ohira, Keiichiro Yoshinaga, Noriyuki Otsuka, Masaharu Nishimura

    Circulation   122 ( 5 )   535 - 6   2010.8

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    DOI： 10.1161/CIRCULATIONAHA.110.952184

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  • Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution. Reviewed International journal

    Mizuho Kondo, Takako Maruoka, Noriyuki Otsuka, Jun Kasamatsu, Kazunori Fugo, Naoto Hanzawa, Masanori Kasahara

    Immunogenetics   62 ( 7 )   441 - 50   2010.7

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    DOI： 10.1007/s00251-010-0438-z

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  • Human endogenous retrovirus-R Env glycoprotein as possible autoantigen in autoimmune disease. Reviewed International journal

    Naomi Sasaki, Yayoi Ogawa, Chihiro Iinuma, Utano Tomaru, Kazuaki Katsumata, Noriyuki Otsuka, Masanori Kasahara, Takashi Yoshiki, Akihiro Ishizu

    AIDS research and human retroviruses   25 ( 9 )   889 - 96   2009.9

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    DOI： 10.1089/aid.2009.0048

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  • Exclusive expression of proteasome subunit {beta}5t in the human thymic cortex. Reviewed International journal

    Utano Tomaru, Akihiro Ishizu, Shigeo Murata, Yukiko Miyatake, Sayuri Suzuki, Satomi Takahashi, Taku Kazamaki, Jiro Ohara, Tomohisa Baba, Sari Iwasaki, Kazunori Fugo, Noriyuki Otsuka, Keiji Tanaka, Masanori Kasahara

    Blood   113 ( 21 )   5186 - 91   2009.5

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    DOI： 10.1182/blood-2008-11-187633

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  • Expression of human endogenous retrovirus-R gene links to differentiation of squamous cells Reviewed

    N. Otsuka, Y. Miyatake, A. Ishizu, S. Tanaka, Y. Yamamoto, H. Ikeda, T. Yoshiki

    AIDS RESEARCH AND HUMAN RETROVIRUSES   22 ( 11 )   1148 - 1151   2006.11

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    DOI： 10.1089/aid.2006.22.1148

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  • Dexamethasone increased plasminogen activator inhibitor-1 expression on human umbilical vein endothelial cells: an additive effect to tumor necrosis factor-alpha. Reviewed International journal

    Yukiyo Yamamoto, Akihiro Ishizu, Hitoshi Ikeda, Noriyuki Otsuka, Takashi Yoshiki

    Pathobiology : journal of immunopathology, molecular and cellular biology   71 ( 6 )   295 - 301   2004

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    DOI： 10.1159/000081724

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  • Tissue specific high level expression of a full length human endogenous retrovirus genome transgene, HERV-R, under control of its own promoter in rats. Reviewed International journal

    Satoshi Tanaka, Hitoshi Ikeda, Noriyuki Otsuka, Yukiyo Yamamoto, Toshiaki Sugaya, Takashi Yoshiki

    Transgenic research   12 ( 3 )   319 - 28   2003.6

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    DOI： 10.1023/A:1023381819572

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  • Pathological features of pulmonary vasculopathy in interstitial lung disease-associated pulmonary hypertension. International journal

    Ayako Igarashi-Sugimoto, Ichizo Tsujino, Hideki Shima, Junichi Nakamura, Toshitaka Nakaya, Takahiro Sato, Taku Watanabe, Hiroshi Ohira, Kei Takamura, Noriyuki Otsuka, Akihiro Ishizu, Sari Iwasaki, Zenichi Tanei, Mishie Tanino, Koji Taniguchi, Shinya Tanaka, Isao Yokota, Satoshi Konno

    Respiratory medicine   248   108395 - 108395   2025.11

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    BACKGROUND: The prognosis of interstitial lung disease-associated pulmonary hypertension remains poor, and the characteristics of the vasculopathy and its underlying pathogenesis are unclear. OBJECTIVE: To investigate the pathological characteristics of pulmonary vasculopathy in interstitial lung disease-associated pulmonary hypertension. METHODS: Autopsy specimens were collected from four groups: control (n = 2), pulmonary arterial hypertension (n = 3), interstitial lung disease-associated pulmonary hypertension (n = 6), and interstitial lung disease without pulmonary hypertension (n = 3). The morphology from the arteries to the veins was quantitively compared, along with the expression of pathogenetic factors and target proteins of pulmonary vasodilators. RESULTS: The percent area stenosis of the muscular arteries and veins were 83 % (71 %-92 %) and 54 % (41 %-70 %), respectively, in the interstitial lung disease-associated pulmonary hypertension group, which were not significantly different compared with other groups except controls. In contrast, for microvessels, the percent area stenosis and muscularization rate in moderate fibrotic areas were significantly higher, and capillary multilayering was also more prominent, in the interstitial lung disease-associated pulmonary hypertension group compared with the interstitial lung disease without pulmonary hypertension group. The expression of pathogenetic factors was not different between interstitial lung disease groups with and without pulmonary hypertension; however, prostaglandin I2 receptors were more strongly expressed in the microvessel wall of interstitial lung disease-associated pulmonary hypertension group than in pulmonary arterial hypertension group. CONCLUSIONS: Interstitial lung disease-associated pulmonary hypertension is pathologically characterized by microvessel remodeling and capillary multilayering. Increased expression of prostaglandin I2 receptor in the microvessels suggests different responses to stimulators of the pathway.

    DOI： 10.1016/j.rmed.2025.108395

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  • Hepatocellular carcinoma with recurrent pancreatic metastasis 17 years after radical resection

    Soichiro Oda, Kazumichi Kawakubo, Shoya Shiratori, Hiroki Yonemura, Shunichiro Nozawa, Ryo Sugiura, Masaki Kuwatani, Noriyuki Otsuka, Shinichi Nakazato, Utano Tomaru, Naoya Sakamoto

    Clinical Journal of Gastroenterology   2025.7

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    Other Link： https://link.springer.com/article/10.1007/s12328-025-02162-7/fulltext.html

    DOI： 10.1007/s12328-025-02162-7

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  • 胸膜播種をきたしたエクリン汗孔癌の一例(A case of eccrine porocarcinoma with pleural dissemination)

    森次 由衣, 種井 善一, 大塚 紀幸, 岡田 宏美, 清水 愛, 酒井 碧, 瀬尾 拓志, 外丸 詩野, 田中 伸哉

    日本病理学会会誌   114 ( 1 )   373 - 373   2025.3

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  • 右耳介後部の結節

    中里 信一, 外丸 詩野, 清水 亜衣, 高桑 恵美, 大塚 紀幸, 前田 拓哉, 今福 恵輔, 阿南 隆, 氏家 英之, 松野 吉宏

    日本皮膚病理組織学会抄録集   39回   40,22 - 40,22   2023.4

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  • Congenital melanocytic nevus syndrome(CMNS)疑い患者に発生し、肺原発性と推定された悪性黒色腫の一例

    大川 紘弥, 中里 信一, 若林 健人, 清水 亜衣, 高桑 恵美, 大塚 紀幸, 外丸 詩野, 藤原 晶, 松野 吉宏

    日本病理学会会誌   112 ( 1 )   326 - 326   2023.3

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  • 肺病変にステロイドが奏功したPOIKTMPの1例(アンコール演題)

    佐藤 理子, 鈴木 雅, 猪狩 智生, 中村 友彦, 高橋 桂, 佐々木 真知子, 木村 孔一, 木村 裕樹, 宮内 俊成, 乃村 俊史, 氏家 英之, 山口 直子, 大塚 紀幸, 外丸 詩野, 今野 哲

    日本呼吸器学会誌   11 ( 増刊 )   272 - 272   2022.4

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  • 肺硬化性肺胞上皮腫および腺癌が同一結節内に併存した一例

    木内 隆之, 木内 静香, 大塚 紀幸, 外丸 詩野, 渡邊 幹夫, 松野 吉宏

    日本病理学会会誌   111 ( 1 )   327 - 327   2022.3

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  • プロテアソーム阻害剤使用後の薬剤性心筋症の一剖検例

    飯田 圭祐, 土橋 大樹, 木内 隆之, 大塚 紀幸, 石立 尚路, 辻 隆裕, 山口 圭介, 外丸 詩野, 深澤 雄一郎, 笠原 正典

    日本病理学会会誌   108 ( 1 )   454 - 454   2019.4

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  • 末梢性T細胞リンパ腫関連血球貪食症候群による劇症肝炎の一例

    村山 千咲, 松田 真奈, 大塚 紀幸, 山口 直子, 木内 隆之, 紺野 潤, 田中 敏, 外丸 詩野, 笠原 正典

    日本病理学会会誌   108 ( 1 )   456 - 456   2019.4

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  • 致死的な腹腔内出血を来した顕微鏡的多発血管炎の一剖検例

    伊丹 久実, 木内 隆之, 外丸 詩野, 大塚 紀幸, 田中 敏, 石津 明洋, 笠原 正典

    日本病理学会会誌   107 ( 1 )   535 - 535   2018.4

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  • Pleuloparenchymal fibroelastosisの病理解剖5症例

    土橋 大樹, 木内 隆之, 桑原 健, 牧田 啓史, 仲川 心平, 鈴木 雅, 大塚 紀幸, 田中 敏, 外丸 詩野, 笠原 正典

    日本病理学会会誌   107 ( 1 )   528 - 528   2018.4

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  • 比較的急速に進行した脱髄疾患の1剖検例

    松林 里佳, 小林 珠代, 木内 隆之, 外丸 詩野, 柳内 充, 大塚 紀幸, 田中 敏, 辻 隆裕, 深澤 雄一郎, 笠原 正典

    日本病理学会会誌   106 ( 1 )   508 - 508   2017.3

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  • 術前に腸間膜由来の腫瘍が疑われた膵神経内分泌腫瘍の1切除例

    松本 嶺, 松井 あや, 野村 俊介, 真木 健裕, 鯉沼 潤吉, 狭間 一明, 渡邊 幹夫, 岩井 和浩, 大塚 紀幸

    日本臨床外科学会雑誌   77 ( 11 )   2812 - 2812   2016.11

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  • 胆嚢悪性腫瘍が疑われたIgG4関連胆嚢炎の一例

    庄子 尚子, 竹元 小乃美, 渡邉 洋章, 木内 隆之, 大塚 紀幸, 和田 雅孝, 外丸 詩野, 笠原 正典

    日本病理学会会誌   105 ( 1 )   579 - 579   2016.4

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  • 術前診断しえた下部胆管原発腺内分泌細胞癌の1例

    京極 典憲, 岩井 和浩, 河合 典子, 細井 勇人, 松井 あや, 狭間 一明, 渡邉 幹夫, 大塚 紀幸

    日本臨床外科学会雑誌   75 ( 9 )   2641 - 2641   2014.9

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  • Pulmonary veno-occlusive disease(PVOD)の一剖検例 Reviewed

    山田 洋介, 大塚 紀幸, 大平 洋, 辻野 一三, 深谷 進司, 外丸 詩野, 石津 明洋

    脈管学   53 ( December )   242 - 243   2013.12

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  • 下部胆管原発腺内分泌細胞癌の1例

    京極 典憲, 岩井 和浩, 河合 典子, 細井 勇人, 松井 あや, 狭間 一明, 渡邉 幹夫, 大塚 紀幸

    日本臨床外科学会雑誌   74 ( 増刊 )   618 - 618   2013.10

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  • 肉芽腫性乳腺炎の1例

    飯村 泰昭, 岩井 和浩, 狭間 一明, 浅野 賢道, 佐藤 暢人, 京極 典憲, 大塚 紀幸, 外丸 詩野

    北海道外科雑誌   57 ( 2 )   195 - 195   2012.12

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  • 肺腺癌に伴うトルソー症候群により肺高血圧症を合併した一剖検例 Reviewed

    今本 鉄平, 大塚 紀幸, 山田 洋介, 外丸 詩野, 高階 太一, 石津 明洋, 笠原 正典

    日本病理学会会誌   101 ( 1 )   439 - 439   2012.3

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  • Erratum: Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution (Immunogenetics DOI: 10.1007/s00251-010-0438-z) Reviewed

    Mizuho Kondo, Takako Maruoka, Noriyuki Otsuka, Jun Kasamatsu, Kazunori Fugo, Naoto Hanzawa, Masanori Kasahara

    Immunogenetics   62 ( 7 )   489 - 490   2010.7

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    DOI： 10.1007/s00251-010-0454-z

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  • Long-term survival after curative left hepatectomy for mucin-producing cholangiocarcinoma: report of a case. Reviewed

    Takahiro Tsuchikawa, Satoshi Kondo, Satoshi Hirano, Eiichi Tanaka, Yoshiyasu Anbo, Toshiaki Morikawa, Shunichi Okushiba, Noriyuki Otsuka, Tomoo Itoh, Hiroyuki Katoh

    Surgery today   35 ( 3 )   256 - 8   2005

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    DOI： 10.1007/s00595-004-2908-0

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  • 肺病変にステロイドが奏功したPOIKTMPの1例(アンコール演題)

    佐藤 理子, 鈴木 雅, 猪狩 智生, 中村 友彦, 高橋 桂, 佐々木 真知子, 木村 孔一, 木村 裕樹, 宮内 俊成, 乃村 俊史, 氏家 英之, 山口 直子, 大塚 紀幸, 外丸 詩野, 今野 哲

    日本呼吸器学会誌   11 ( 増刊 )   272 - 272   2022.4

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  • 肺高血圧合併間質性肺疾患における肺血管病変の病理学的解析

    杉本絢子, 辻野一三, 辻野一三, 大塚紀幸, 中村順一, 佐藤隆博, 大平洋, 鈴木雅, 高村圭, 石田雄介, 田中伸哉, 今野哲

    日本肺高血圧・肺循環学会学術集会抄録集(Web)   7th   2022

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  • Contribution of microvessel-remodeling to the complication of pulmonary hypertension in interstitial lung disease

    杉本絢子, 辻野一三, 大塚紀幸, 石田雄介, 中村順一, 中谷資隆, 佐藤隆博, 大平洋, 鈴木雅, 高村圭, 田中伸哉, 今野哲

    日本呼吸器学会誌(Web)   11   2022

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  • 間質性肺疾患合併肺高血圧症の肺血管形態に関する病理学的検討

    杉本絢子, 辻野一三, 大塚紀幸, 中村順一, 中谷資隆, 佐藤隆博, 渡部拓, 大平洋, 今野哲

    日本肺高血圧・肺循環学会学術集会抄録集(Web)   6th   2021

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  • 肺炎を繰り返した後、頻回の喀血を呈した高度肺気腫の1例

    合田 大樹, 池澤 靖元, 有里 仁希, 嘉島 相裕, 河井 康孝, 木内 隆之, 大塚 紀幸

    王子総合病院医学雑誌   ( 10 )   73 - 76   2020.7

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  • 診断困難な貧血と肝腫瘍を併発した一例

    石塚 理恵, 山田 尚太, 木内 隆之, 大塚 紀幸

    王子総合病院医学雑誌   ( 8 )   77 - 81   2018.7

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  • 致死的な腹腔内出血を来した顕微鏡的多発血管炎の一剖検例

    伊丹 久実, 木内 隆之, 外丸 詩野, 大塚 紀幸, 田中 敏, 石津 明洋, 笠原 正典

    日本病理学会会誌   107 ( 1 )   535 - 535   2018.4

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  • 胆管原発large cell neuroendocrine carcinomaの1例と文献報告例の検討

    京極 典憲, 岩井 和浩, 吉見 泰典, 細井 勇人, 松井 あや, 佐藤 暢人, 狭間 一明, 渡邊 幹夫, 大塚 紀幸, 平野 聡

    日本消化器外科学会雑誌   50 ( 1 )   33 - 42   2017.1

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  • Alteration of placental structure in NKG2D-deficient mice

    Noriyuki Otsuka, Misa Tokunaga, Youka Aoki, Masanori Kasahara

    JOURNAL OF REPRODUCTIVE IMMUNOLOGY   118   110 - 110   2016.11

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    DOI： 10.1016/j.jri.2016.10.005

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  • 特発性肺線維症に慢性進行性アスペルギルス症を併発し急速に悪化した一例

    羽生 佳弘, 阿部 結希, 國崎 守, 河井 康孝, 木内 隆之, 大塚 紀幸

    王子総合病院医学雑誌   ( 6 )   97 - 98   2016.6

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  • 腹壁に発症した巨大平滑筋肉腫の1例

    高橋 紀久子, 本田 進, 北條 正洋, 木村 中, 木内 隆之, 大塚 紀幸

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   32回   125 - 125   2016.5

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  • 胸腺上皮性腫瘍におけるカテプシンV及びカテプシンSの発現

    木内 静香, 外丸 詩野, 石津 明洋, 大塚 紀幸, 今川 誠, 岩崎 沙理, 鈴木 昭, 丸川 活司, 松野 吉宏, 笠原 正典

    日本病理学会会誌   105 ( 1 )   471 - 471   2016.4

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  • 肺移植施行後に日和見感染症により死亡に至った肺ランゲルハンス細胞組織球症の一例

    四宮 万里絵, 松林 里佳, 外丸 詩野, 木内 隆之, 大塚 紀幸, 石津 明洋, 笠原 正典

    日本病理学会会誌   105 ( 1 )   585 - 585   2016.4

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  • 悪性腹膜中皮腫との鑑別に苦慮したatypical mesothelial proliferationの1例

    石川 麻美, 堀井 恒哉, 小山内 翔祐, 勘野 真紀, 大塚 紀幸, 外丸 詩野, 石津 明洋, 高木 芳武

    日本臨床細胞学会雑誌   54 ( Suppl.1 )   279 - 279   2015.4

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  • ダウン症患者の胸腺におけるプロテアソームサブユニットβ5tの発現低下

    木内 静香, 外丸 詩野, 辻 隆裕, 石津 明洋, 鈴木 昭, 大塚 紀幸, 伊藤 智樹, 池田 仁, 深澤 雄一郎, 笠原 正典

    日本病理学会会誌   104 ( 1 )   460 - 460   2015.3

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  • TypeB胸腺腫、胸腺癌におけるカテプシンの発現

    安部 樹太朗, 有賀 茜, 外丸 詩野, 木内 静香, 石津 明洋, 大塚 紀幸, 清水 知浩, 丸川 活司, 松野 吉宏, 笠原 正典

    日本病理学会会誌   104 ( 1 )   528 - 528   2015.3

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  • 壁在結節を伴う卵巣粘液産生腺癌の3例

    河内 麻里亜, 横山 達也, 大塚 紀幸, 藤本 俊郎, 池田 仁, 高木 芳武, 石津 明洋, 外丸 詩野, 笠原 正典

    日本病理学会会誌   104 ( 1 )   522 - 522   2015.3

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  • 顕微鏡的多発血管炎と血栓症はMPO-ANCAと好中球細胞外トラップを介して関連する

    今本 鉄平, 中沢 大悟, 志田 玄貴, 鈴木 昭, 大塚 紀幸, 外丸 詩野, 石津 明洋

    北海道医学雑誌   89 ( 1 )   91 - 91   2014.5

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  • 高齢男性でみられたEBV陽性肝脾γδT細胞リンパ腫の一例

    竹中 淳規, 大塚 紀幸, 藤田 裕美, 中馬 誠, 外丸 詩野, 石津 明洋, 笠原 正典

    日本病理学会会誌   103 ( 1 )   407 - 407   2014.3

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  • リツキシマブ投与後に日和見感染症を併発した顕微鏡的多発血管炎の一剖検例

    味藤 静, 外丸 詩野, 大塚 紀幸, 石津 明洋, 笠原 正典

    日本病理学会会誌   102 ( 1 )   503 - 503   2013.4

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  • HELLP症候群に合併したhepatic ruptureの一剖検例

    山本 岳, 藤井 真理子, 大塚 紀幸, 光部 兼六郎, 櫻井 宏治, 外丸 詩野, 石津 明洋, 笠原 正典

    日本病理学会会誌   102 ( 1 )   502 - 502   2013.4

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  • 顕微鏡的多発血管炎と血栓症はMPO-ANCAと好中球細胞外トラップを介して関連する

    今本 鉄平, 中沢 大悟, 大塚 紀幸, 外丸 詩野, 笠原 正典, 石津 明洋

    日本病理学会会誌   102 ( 1 )   502 - 502   2013.4

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  • 胎盤形成期におけるNKG2Dリガンド発現意義の検討

    大塚紀幸, 山本菜見子, 須藤洋一, 宮武由甲子, 笠原正典

    日本病理学会会誌   102 ( 1 )   2013

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  • Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair

    MOHAMED Rania Hassan

    北海道醫學雜誌 = Acta medica Hokkaidonensia   87 ( 6 )   279 - 279   2012.11

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  • 胸腺の系統発生:無顎類における新規T細胞様細胞の解析

    須藤洋一, 笠松純, 大塚紀幸, 富居一範, 笠原正典

    日本胸腺研究会プログラム・抄録集   31st   2012

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  • NKG2Dリガンドの創傷治癒における役割の解析

    笠原 正典, Mohamed Rania, 小泉 潤, 富居 一範, 大塚 紀幸, 吉田 繁

    MHC: Major Histocompatibility Complex   18 ( 2 )   153 - 153   2011.8

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  • [An autopsy case of asbestos-related pleomorphic carcinoma of the lung].

    Yoshihiro Ohata, Tsuyoshi Nakano, Yukiko Maeda, Kozo Kubo, Noriyuki Otsuka, Kenzo Okamoto

    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society   49 ( 4 )   277 - 81   2011.4

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    A 50-year-old man with a history of asbestos inhalation developed symptoms related to a metastatic brain tumor was admitted. Chest X-ray images showed an opacity in the left lower lung field. We were unable to differentiate between lung cancer and malignant pleural tumor using either transbronchial lung biopsy or computed tomography (CT)-guided needle biopsy. After 3 months the patient died from rapid disease progression despite radiation therapy, drainage of large quantities of the pleural effusion and chemotherapy. A diagnosis of asbestos-related pleomorphic carcinoma of the lung was made after autopsy and immunohistochemical examination of the tumor.

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  • 肺静脈閉塞症における細胞増殖因子の関与

    谷野美智枝, 中村紘子, 木村太一, 大塚紀幸, 深澤雄一郎, 西川祐司, 池田健, 西原広史, 田中伸哉, 田中伸哉

    日本病理学会会誌   100 ( 1 )   376   2011.3

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  • BCG接種後に判明した慢性肉芽腫症の一剖検例

    定本 圭弘, 大塚 紀幸, 藤田 裕美, 菊地 慶介, 外丸 詩野, 石津 明洋, 笠原 正典

    日本病理学会会誌   100 ( 1 )   494 - 494   2011.3

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  • ヒトNKG2Dリガンドの組織発現に関する免疫組織化学検討

    藤田 裕美, 須藤 洋一, 畑中 豊, 富居 一範, 大塚 紀幸, 松野 吉宏, 笠原 正典

    日本病理学会会誌   100 ( 1 )   367 - 367   2011.3

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  • 体表組織におけるナチュラルキラー細胞活性化リガンドH60cの役割

    吉田 繁, 小泉 潤, 富居 一範, 近藤 瑞穂, 大塚 紀幸, 笠原 正典

    日本病理学会会誌   100 ( 1 )   366 - 366   2011.3

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  • 新規の可変性リンパ球受容体VLRCを発現するリンパ球様細胞集団の同定

    須藤洋一, 笠松純, 富居一範, 大塚紀幸, 岩渕和也, 笠原正典

    日本比較免疫学会学術集会講演要旨   23rd   2011

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  • Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution (vol 62, pg 441, 2010)

    Mizuho Kondo, Takako Maruoka, Noriyuki Otsuka, Jun Kasamatsu, Kazunori Fugo, Naoto Hanzawa, Masanori Kasahara

    IMMUNOGENETICS   62 ( 10 )   709 - 710   2010.10

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  • The incidence and the mechanism of sunitinib-induced thyroid atrophy in patients with metastatic renal cell carcinoma

    N. Shinohara, M. Takahashi, T. Kamishima, H. Ikushima, N. Otsuka, A. Ishizu, A. Sazawa, H. Kanayama, K. Nonomura

    JOURNAL OF CLINICAL ONCOLOGY   28 ( 15 )   2010.5

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  • 粘膜免疫におけるナチュラルキラー細胞活性化リガンドH60cの役割

    吉田 繁, 富居 一範, 近藤 瑞穂, 大塚 紀幸, 笠原 正典

    日本病理学会会誌   99 ( 1 )   272 - 272   2010.3

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  • 近交系マウスにおけるNKG2Dリガンド遺伝子のコピー数多型

    富居 一範, 皿田 雄二, 笠松 純, 近藤 瑞穂, 吉田 繁, 須藤 洋一, 大塚 紀幸, 笠原 正典

    日本病理学会会誌   99 ( 1 )   274 - 274   2010.3

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  • NKT細胞とその他の自然リンパ球 基礎的解析 第3のvariable lymphocyte receptorの同定(Identification of a novel variable lymphocyte receptor)

    須藤 洋一, 大塚 紀幸, 富居 一範, 笠原 正典

    日本免疫学会総会・学術集会記録   39   59 - 59   2009.11

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  • 腎癌患者へのSunitinib投与が引き起こす甲状腺機能障害の発症機序

    篠原 信雄, 高橋 正幸, 神島 保, 生島 仁史, 大塚 紀幸, 石津 明洋, 丸山 覚, 安部 崇重, 佐澤 陽, 金山 博臣, 野々村 克也

    日本癌治療学会誌   44 ( 2 )   456 - 456   2009.9

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  • 弛張熱で発症した原発性胆汁性肝硬変、自己免疫性肝炎合併シェーグレン症候群の1例

    河野 通仁, 佐藤 力, 野本 博司, 谷口 聡, 田村 元男, 山根 康昭, 浄土 智, 藤咲 淳, 石津 明洋, 大塚 紀幸, 富居 一範

    北海道医学雑誌   84 ( 5 )   403 - 404   2009.9

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  • MPO-ANCA陽性であったが糸球体腎炎や血管炎は確認されず、間質性肺炎に感染症を合併して死亡した症例

    石津 明洋, 岩崎 沙理, 外丸 詩野, 武田 広子, 大塚 紀幸, 富居 一範, 笠原 正典, 清水 健一, 南須原 康行, 西村 正治

    北海道医学雑誌   84 ( 5 )   403 - 403   2009.9

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  • 皮膚免疫に重要な役割を果たすと推定される新しいMHCクラスI様分子の解析

    吉田繁, 富居一範, 梶川瑞穂, 近藤瑞穂, 大塚紀幸, 前仲勝実, 笠原正典

    MHC   16 ( 2 )   178 - 178   2009.8

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  • 皮膚免疫におけるマウスNKG2DリガンドH60cの役割

    吉田繁, 富居一範, 梶川瑞穂, 笠松純, 皿田雄二, 大塚紀幸, 笠原正典

    日本病理学会会誌   98 ( 1 )   366 - 366   2009.3

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  • 新規分子Variable lymphocyte receptor(VLR)の抗体代替試薬としての可能性

    須藤 洋一, 大塚 紀幸, 富居 一範, 笠原 正典

    日本病理学会会誌   98 ( 1 )   346 - 346   2009.3

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  • 分子標的薬sunitinib投与症例における甲状腺萎縮の病理学的解析

    中村 静香, 大塚 紀幸, 鈴木 昭, 富居 一範, 外丸 詩野, 笠原 正典, 石津 明洋

    日本病理学会会誌   98 ( 1 )   400 - 400   2009.3

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  • 特殊なリンパ球 NK細胞や他のリンパ球 マウスNKG2DリガンドH60cの皮膚免疫における役割

    吉田 繁, 富居 一範, 笠松 純, 皿田 雄二, 大塚 紀幸, 笠原 正典

    日本免疫学会総会・学術集会記録   38   72 - 72   2008.11

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  • 肺限局型MPO-ANCA関連血管炎と考えられた一剖検例

    外丸 詩野, 武田 広子, 岩崎 沙理, 大塚 紀幸, 富居 一範, 笠原 正典, 清水 健一, 南須原 康行, 西村 正治, 石津 明洋

    日本病理学会会誌   97 ( 2 )   33 - 33   2008.9

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  • 新規NKG2DリガンドH60b、H60cの機能解析(Functional analysis of novel members of NKG2D ligand, H60b and H60c)

    富居 一範, 吉田 繁, 大塚 紀幸, 外丸 詩野, 笠原 正典

    日本癌学会総会記事   67回   443 - 444   2008.9

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  • O05-04 術前悪性胸膜中皮腫が疑われた,壁側胸膜原発腺癌の1例(胸膜中皮腫,第25回日本呼吸器外科学会総会)

    妻鹿 成治, 川崎 亮輔, 浅野 賢道, 狭間 一明, 岩井 和浩, 大塚 紀幸, 石津 明洋

    日本呼吸器外科学会雑誌   22 ( 3 )   419 - 419   2008.4

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    DOI： 10.2995/jacsurg.22.419_4

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  • NKG2DリガンドH60b、H60cの機能解析

    吉田 繁, 富居 一範, 大塚 紀幸, 外丸 詩野, 笠原 正典

    日本病理学会会誌   97 ( 1 )   203 - 203   2008.3

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  • 術前悪性胸膜中皮腫が疑われた、壁側胸膜原発腺癌の1例

    妻鹿 成治, 川崎 亮輔, 浅野 賢道, 狭間 一明, 岩井 和浩, 大塚 紀幸, 石津 明洋

    日本臨床外科学会雑誌   68 ( 9 )   2422 - 2422   2007.9

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  • 自己免疫状態におけるヒト内在性レトロウイルスHERV-Rの抗原性について

    石津 明洋, 佐々木 直美, 田中 敏, 大塚 紀幸, 鈴木 昭, 外丸 詩野, 池田 仁, 笠原 正典, 吉木 敬

    日本免疫学会総会・学術集会記録   35   35 - 35   2005.11

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  • [Expression of retroviral env protein and its antigenisity in the transgenic rat carrying human endogenous retrovirus gene, HERV-R].

    Noriyuki Otsuka

    [Hokkaido igaku zasshi] The Hokkaido journal of medical science   78 ( 6 )   549 - 56   2003.11

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  • HERV-RトランスジェニックラットにおけるEnv蛋白発現と抗原性の解析

    大塚 紀幸, 田中 敏, 山本 友希代, 石津 明洋, 池田 仁, 吉木 敬

    日本病理学会会誌   92 ( 1 )   256 - 256   2003.4

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  • Tissue specific expression of the Env protein in fetus rats carrying a full length HERV-R gene.

    N Otsuka, H Ikeda, S Tanaka, A Ishizu, T Yoshiki

    AIDS RESEARCH AND HUMAN RETROVIRUSES   19   S67 - S67   2003

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  • ERV3トランスジェニックラットにおけるヒトレトロウイルス外被蛋白発現と免疫機能の解析

    大塚 紀幸, 田中 敏, 山本 友希代, 石津 明洋, 池田 仁, 吉木 敬

    日本病理学会会誌   91 ( 1 )   201 - 201   2002.3

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  • ERV3トランスジェニックラットにおけるヒトレトロウイルス外被蛋白発現の解析

    大塚 紀幸, 田中 敏, 山本 友希代, 石津 明洋, 池田 仁, 吉木 敬

    日本免疫学会総会・学術集会記録   31   116 - 116   2001.12

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  • 4.腎癌Endobronchial Metastasisの気道狭窄に対しArgon Plasma Coagulation(APC)が有効であった1症例(第22回日本気管支学会北海道支部会)

    白間 信行, 若林 修, 福元 伸一, 横内 浩, 原田 敏之, 小島 哲弥, 大泉 聡史, 本村 文宏, 山崎 浩一, 小倉 滋明, 秋田 弘俊, 西村 正治, 大塚 紀幸, 村上 貴久, 清水 道生

    気管支学 : 日本気管支研究会雑誌   23 ( 5 )   494 - 494   2001.7

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    DOI： 10.18907/jjsre.23.5_494_4

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  • A case of inflammatory fibrosarcoma of the retroperitoneum

    Atsumori Ueno, Itaru Ozeki, Shigeru Sasaki, Sumio Yamaguchi, Norikazu Iwata, Hiroyuki Kaneto, Fumio Itoh, Takao Endo, Shingo Ichimiya, Masaaki Satoh, Noriyuki Otsuka, Michio Shimizu, Michiaki Matsushita, Satoru Todo, Kohzoh Imai

    Japanese Journal of Gastroenterology   98 ( 4 )   436 - 441   2001.4

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    DOI： 10.11405/nisshoshi1964.98.436

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  • ERV3トランスジェニックラットにおけるヒトレトロウイルス外被蛋白発現の解析

    大塚 紀幸, 田中 敏, 山本 友希代, 石津 明洋, 柴田 雅彦, 池田 仁, 吉木 敬

    日本病理学会会誌   90 ( 1 )   156 - 156   2001.3

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  • Expression of the env protein in transgenic rats carrying the full length HERV-R gene

    N Otsuka, H Ikeda, S Tanaka, A Ishizu, T Yoshiki

    AIDS RESEARCH AND HUMAN RETROVIRUSES   17   S17 - S17   2001

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  • トランスジェニックラットを用いたヒト内在性レトロウイルスERV3の病原性の解析

    大塚 紀幸, 田中 敏, 山本 友希代, 石津 明洋, 柴田 雅彦, 池田 仁, 吉木 敬

    日本免疫学会総会・学術集会記録   30   65 - 65   2000.11

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  • ERV3遺伝子導入ラットを用いたヒト内在性レトロウイルスの病因論的解析

    石津 明洋, 田中 敏, 山本 友希代, 大塚 紀幸, 柴田 雅彦, 池田 仁, 吉木 敬

    リウマチ   40 ( 2 )   526 - 526   2000.4

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  • ヒト内在性レトロウイルスERV3トランスジェニックラットにおける導入遺伝子の発現と抗原性の解析

    大塚 紀幸, 田中 敏, 山本 友希代, 石津 明洋, 柴田 雅彦, 池田 仁, 吉木 敬

    日本病理学会会誌   89 ( 1 )   192 - 192   2000.3

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Awards

  • 学会賞（JRI賞）

    第31回日本生殖免疫学会総会・学術集会  

    大塚 紀幸

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Research Projects

  • Analysis for placental development via uNK cells and NKG2D system

    Grant number：16K11076  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    OTSUKA Noriyuki

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    Variety of immune cells are involved in placental development. Uterine NK cells play the key role in the process. In this project, we analyzed the role and the mechanism of NKG2D receptor and its ligands interaction using murine models. Mild hypoxic condition in placenta aids the tissue remodeling in the placenta. We employed a murine skin ischemia-reperfusion ulcer model to prove that NKG2D receptor-ligands interaction contributes to the immune control and the tissue remodeling. These results suggest that NKG2D system induced by hypoxia promote the placental development.

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  • Role of NKG2D ligands in pathologic conditions

    Grant number：15H04716  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kasahara Masanori

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    Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）

    NKG2D ligands are a group of major histocompatibility complex class I-like molecules whose expression is induced by cellular stresses such as transformation and viral infections. They act as a danger signal alerting the immune system to the presence of abnormal cells. In this project, we analyzed the role of NKG2D ligands in pressure ulcers and placental development using mouse models. We also conducted molecular evolutionary analysis of the NKG2D ligand gene family in mammals.

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  • Role of NKG2D ligands in immunological surveillance and disease pathogenesis

    Grant number：24390091  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KASAHARA Masanori, OTSUKA Noriyuki, MIYATAKE Yukiko

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    Grant amount：\18720000 （ Direct Cost: \14400000 、 Indirect Cost：\4320000 ）

    NKG2D ligands are a group of major histocompatibility complex class I-like molecules whose expression is induced by cellular stresses such as transformation and viral infections. They act as a danger signal alerting the immune system to the presence of abnormal cells. In this project, we analyzed the function of H60c, a mouse NKG2D ligand assumed to be involved in the immune surveillance and maintenance of homeostasis at body surfaces. We also analyzed the expression of NKG2D ligands in human cancer.

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  • NKG2D ligand expression in the murine placenta

    Grant number：24790373  2012.4 - 2014.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    OTSUKA Noriyuki

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    Uterine NK (uNK) cells reside in the fetomaternal interface in early gestation. Although the activity of uNK cells is known to be controlled via the interaction of the NKG2D receptor and its ligands, little is known as to whether NKG2D ligand-receptor interactions contribute to placental development. To elucidate the role of the NKG2D system at the fetomaternal interface in vivo, we treated pregnant mice with anti-NKG2D antibodies and analyzed the morphology of implantation sites and placenta. NKG2D blockade led to the alteration of placental structure and its size, though the number and the weight of fetus were not influenced. The mechanism underlying NKG2D-associated placental development remains unresolved.

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  • Abnormal NKG2D ligand expression and disease

    Grant number：21390112  2009 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KASAHARA Masanori, FUGO Kazunori, OTSUKA Noriyuki

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    Grant amount：\18590000 （ Direct Cost: \14300000 、 Indirect Cost：\4290000 ）

    NKG2D ligands are major histocompatibility complex class I-like molecules whose expression is induced by cellular stresses such as transformation and viral infections. They function as danger signals alerting the immune system to the presence of unhealthy, stressed cells. In the present study, we analyzed the structure and function of NKG2D ligands, and their role in pathologic processes, with emphasis on the analysis of H60c, a mouse NKG2D ligand identified in our laboratory.

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  • Analysis of premature ovarian failure in fragile X syndrome

    Grant number：19790279  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    OTUSKA Noriyuki

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    Grant amount：\3840000 （ Direct Cost: \3300000 、 Indirect Cost：\540000 ）

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