研究者詳細 - 浜田　亮

写真a

ハマダ　リョウ

浜田　亮

所属

医学部小児科学講座助教

外部リンク

論文

Successful treatment of pediatric mature B-cell lymphoma with MYC and BCL6 rearrangements. 国際誌

Ryo Hamada, Masaki Yamamoto, Yusuke Akane, Keita Igarashi, Takeshi Tsugawa

Pediatrics international : official journal of the Japan Pediatric Society 67 ( 1 ) e70037 2025年

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/ped.70037

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Crizotinib therapy for congenital embryonal rhabdomyosarcoma associated with an ATIC-ALK gene fusion. 国際誌

Yusuke Akane, Masaki Yamamoto, Akira Takebayashi, Ryo Hamada, Keita Igarashi, Makoto Emori, Shintaro Sugita, Kohichi Takada, Tadashi Hasegawa, Takeshi Tsugawa

Pediatric blood & cancer 71 ( 9 ) e31148 2024年9月

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記述言語：英語

DOI： 10.1002/pbc.31148

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Molecular evolutionary analysis of novel NSP4 mono-reassortant G1P[8]-E2 rotavirus strains that caused a discontinuous epidemic in Japan in 2015 and 2018. 国際誌

Yoshiki Fujii, Takeshi Tsugawa, Yuya Fukuda, Shuhei Adachi, Saho Honjo, Yusuke Akane, Kenji Kondo, Yoshiyuki Sakai, Toju Tanaka, Toshiya Sato, Yoshihito Higasidate, Noriaki Kubo, Toshihiko Mori, Shinsuke Kato, Ryo Hamada, Masayoshi Kikuchi, Yasuo Tahara, Kazushige Nagai, Toshio Ohara, Masaki Yoshida, Shuji Nakata, Atsuko Noguchi, Wakako Kikuchi, Hiromichi Hamada, Shoko Tokutake-Hirose, Makoto Fujimori, Masamichi Muramatsu

Frontiers in microbiology 15 1430557 - 1430557 2024年

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記述言語：英語掲載種別：研究論文（学術雑誌）

In the 2010s, several unusual rotavirus strains emerged, causing epidemics worldwide. This study reports a comprehensive molecular epidemiological study of rotaviruses in Japan based on full-genome analysis. From 2014 to 2019, a total of 489 rotavirus-positive stool specimens were identified, and the associated viral genomes were analyzed by next-generation sequencing. The genotype constellations of those strains were classified into nine patterns (G1P[8] (Wa), G1P[8]-E2, G1P[8] (DS-1), G2P[4] (DS-1), G3P[8] (Wa), G3P[8] (DS-1), G8P[8] (DS-1), G9P[8] (Wa), and G9P[8]-E2). The major prevalent genotype differed by year, comprising G8P[8] (DS-1) (37% of that year's isolates) in 2014, G1P[8] (DS-1) (65%) in 2015, G9P[8] (Wa) (72%) in 2016, G3P[8] (DS-1) (66%) in 2017, G1P[8]-E2 (53%) in 2018, and G9P[8] (Wa) (26%) in 2019. The G1P[8]-E2 strains (G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1) isolated from a total of 42 specimens in discontinuous years (2015 and 2018), which were the newly-emerged NSP4 mono-reassortant strains. Based on the results of the Bayesian evolutionary analyses, G1P[8]-E2 and G9P[8]-E2 were hypothesized to have been generated from distinct independent inter-genogroup reassortment events. The G1 strains detected in this study were classified into multiple clusters, depending on the year of detection. A comparison of the predicted amino acid sequences of the VP7 epitopes revealed that the G1 strains detected in different years encoded VP7 epitopes harboring distinct mutations. These mutations may be responsible for immune escape and annual changes in the prevalent strains.

DOI： 10.3389/fmicb.2024.1430557

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Rivaroxaban for severe superior sagittal sinus thrombosis in a child with ALL.

Masaki Yamamoto, Yusuke Akane, Ryo Hamada, Hiroyuki Kabutoya, Keita Igarashi, Sangnyon Kim, Takeshi Tsugawa

International journal of hematology 118 ( 3 ) 309 - 310 2023年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s12185-023-03640-9

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Impact of BRAF/MEK inhibitor on BRAF V600E-mutated pilocytic astrocytoma. 国際誌

Ryo Hamada, Yusuke Akane, Yukinori Akiyama, Kohichi Takada, Masaki Yamamoto

Pediatrics international : official journal of the Japan Pediatric Society 65 ( 1 ) e15653 2023年

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/ped.15653

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Surveillance in hospitalized children with infectious diseases in Japan: Pre- and post-coronavirus disease 2019. 国際誌

Yuya Fukuda, Takeshi Tsugawa, Yoshinobu Nagaoka, Akira Ishii, Tomohiro Nawa, Atsuo Togashi, Jun Kunizaki, Satoshi Hirakawa, Junya Iida, Toju Tanaka, Toshitaka Kizawa, Dai Yamamoto, Ryoh Takeuchi, Yoshiyuki Sakai, Masayoshi Kikuchi, Kazushige Nagai, Hirofumi Asakura, Rina Tanaka, Masaki Yoshida, Ryo Hamada, Yukihiko Kawasaki

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 27 ( 11 ) 1639 - 1647 2021年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: The epidemic of coronavirus disease 2019 (COVID-19) rapidly spread worldwide, and the various infection control measures have a significant influence on the spread of many infectious diseases. However, there have been no multicenter studies on how the number of hospitalized children with various infectious diseases changed before and after the outbreak of COVID-19 in Japan. METHODS: We conducted a multicenter, prospective survey for hospitalized pediatric patients in 18 hospitals in Hokkaido Prefecture, Japan, from July 2019 to February 2021. We defined July 2019 to February 2020 as pre-COVID-19, and July 2020 to February 2021 as post-COVID-19. We surveyed various infectious diseases by sex and age. RESULTS: In total, 5300 patients were hospitalized during the study period. The number of patients decreased from 4266 in the pre-COVID-19 period to 701 (16.4%) post-COVID-19. Patients with influenza and RSV decreased from 308 to 795 pre-COVID-19 to zero and three (0.4%) post-COVID-19. However, patients with adenovirus (respiratory infection) only decreased to 60.9% (46-28) of pre-COVID levels. Patients with rotavirus, norovirus, and adenovirus gastroenteritis decreased markedly post-COVID-19 to 2.6% (38-1), 27.8% (97-27) and 13.5% (37-5). The number of patients with UTIs was similar across the two periods (109 and 90). KD patients decreased to 31.7% (161-51) post-COVID-19. CONCLUSIONS: We suggest that current infection control measures for COVID-19 such as wearing masks, washing hands, and disinfecting hands with alcohol are effective against various infectious diseases. However, these effects vary by disease.

DOI： 10.1016/j.jiac.2021.07.024

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