研究者詳細 - 小池　和茂

写真a

コイケ　カズシゲ

小池　和茂

所属

医学部口腔外科学講座助教

ORCID ID

0000-0001-6880-2454

外部リンク

学位

医学博士（ 2020年札幌医科大学）

研究キーワード

免疫染色
口腔癌

学歴

National Institute of Health

2022年 - 2025年

　詳細を見る

国名：アメリカ合衆国

researchmap
札幌医科大学大学院医学研究科

2016年 - 2020年

　詳細を見る

researchmap
北海道大学歯学部

2009年 - 2015年

　詳細を見る

researchmap

論文

Suspected Thyroid Storm in a Patient Undergoing Internal Fixation for a Left Mandibular Fracture Under General Anesthesia: A Case Report. 国際誌

Mako Domi, Kazushige Koike, Tomohiro Chaki, Takashi Sasaya, Akihiro Miyazaki

Cureus 17 ( 7 ) e88917 2025年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Thyroid storm is a life-threatening condition in which patients with untreated or poorly controlled thyroid disease experience excessive thyroid hormone action triggered by severe stress, resulting in multiple organ dysfunction. We present a case of suspected thyroid storm during surgery for a left mandibular fracture under general anesthesia. The patient was a 23-year-old male, and a preoperative interview revealed no notable medical history. During open reduction and internal fixation under general anesthesia, the patient developed sinus tachycardia, hypertension, elevated end-tidal carbon dioxide, and persistent hyperthermia. Based on these clinical findings, malignant hyperthermia was initially suspected. However, the absence of myoglobinuria led to the exclusion of this diagnosis, and the surgery was continued. After emerging from general anesthesia, the persistent tachycardia, hypertension, and hyperthermia did not improve; therefore, a physical examination was performed, revealing an enlarged thyroid gland. Furthermore, blood tests showed an abnormally high free triiodothyronine level and an abnormally low thyroid-stimulating hormone level. After referral to the endocrinology department, the patient was diagnosed with hyperthyroidism and a suspected thyroid storm triggered by trauma and surgical stress. In conclusion, thyroid storm should be considered as a differential diagnosis in cases of unexplained refractory tachycardia, hyperthermia, or hypercapnia during anesthesia management.

DOI： 10.7759/cureus.88917

PubMed

researchmap
A rare case report of diverticulum of the buccal mucosa

Kazushige Koike, Hinako Mori, Kazuhiro Ogi, Makiya Jin, Satoshi Ohwada, Takahiro Iwamoto, Shintaro Sugita, Tadashi Hasegawa, Akihiro Miyazaki

Clinical Case Reports 11 ( 7 ) 2023年7月

　詳細を見る

掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

DOI： 10.1002/ccr3.7566

researchmap
Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy. 国際誌

Sho Miyamoto, Yoshihiko Hirohashi, Rena Morita, Akihiro Miyazaki, Kazuhiro Ogi, Takayuki Kanaseki, Kentaro Ide, Jumpei Shirakawa, Tomohide Tsukahara, Aiko Murai, Takashi Sasaya, Kazushige Koike, Shinichiro Kina, Toshihiro Kawano, Takahiro Goto, Edward Hosea Ntege, Yusuke Shimizu, Toshihiko Torigoe

Cancer science 114 ( 9 ) 3496 - 3508 2023年6月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

The mortality rate of oral cancer has not improved over the past three decades despite remarkable advances in cancer therapies. Oral cancers contain a subpopulation of cancer stem cells (CSCs) that share characteristics associated with normal stem cells, including self-renewal and multi-differentiation potential. CSCs are tumorigenic, play a critical role in cancer infiltration, recurrence, and distant metastasis, and significantly contribute to drug resistance to current therapeutic strategies, including immunotherapy. Cytotoxic CD8+ T lymphocytes (CTLs) are key immune cells that effectively recognize peptide antigens presented by the major histocompatibility complex class I molecules. Increasing evidence suggests that cancer antigen-specific targeting by CTLs effectively regulates CSCs that drive cancer progression. In this study, we utilized data from public domains and performed various bioassays on human oral squamous cell carcinoma clinical samples and cell lines, including HSC-2 and HSC-3, to investigate the potential role of olfactory receptor family 7 subfamily C member 1 (OR7C1), a seven transmembrane G-protein-coupled olfactory receptor that is also expressed in nonolfactory tissues and was previously reported as a novel marker and target of colon cancer initiating cell-targeted immunotherapy, in CSC-targeted treatment against oral cancer. We found that the OR7C1 gene was expressed only in oral CSCs, and that CTLs reacted with human leukocyte antigen-A24-restricted OR7C1 oral CSC-specific peptides. Taken together, our findings suggest that OR7C1 represents a novel target for potent CSC-targeted immunotherapy in oral cancer.

DOI： 10.1111/cas.15873

PubMed

researchmap
ARH Family of ADP-Ribose-Acceptor Hydrolases. 国際誌

Hiroko Ishiwata-Endo, Jiro Kato, Sachiko Yamashita, Chanbora Chea, Kazushige Koike, Duck-Yeon Lee, Joel Moss

Cells 11 ( 23 ) 2022年11月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

The ARH family of ADP-ribose-acceptor hydrolases consists of three 39-kDa members (ARH1-3), with similarities in amino acid sequence. ARH1 was identified based on its ability to cleave ADP-ribosyl-arginine synthesized by cholera toxin. Mammalian ADP-ribosyltransferases (ARTCs) mimicked the toxin reaction, with ARTC1 catalyzing the synthesis of ADP-ribosyl-arginine. ADP-ribosylation of arginine was stereospecific, with β-NAD+ as substrate and, α-anomeric ADP-ribose-arginine the reaction product. ARH1 hydrolyzed α-ADP-ribose-arginine, in addition to α-NAD+ and O-acetyl-ADP-ribose. Thus, ADP-ribose attached to oxygen-containing or nitrogen-containing functional groups was a substrate. Arh1 heterozygous and knockout (KO) mice developed tumors. Arh1-KO mice showed decreased cardiac contractility and developed myocardial fibrosis. In addition to Arh1-KO mice showed increased ADP-ribosylation of tripartite motif-containing protein 72 (TRIM72), a membrane-repair protein. ARH3 cleaved ADP-ribose from ends of the poly(ADP-ribose) (PAR) chain and released the terminal ADP-ribose attached to (serine)protein. ARH3 also hydrolyzed α-NAD+ and O-acetyl-ADP-ribose. Incubation of Arh3-KO cells with H2O2 resulted in activation of poly-ADP-ribose polymerase (PARP)-1, followed by increased nuclear PAR, increased cytoplasmic PAR, leading to release of Apoptosis Inducing Factor (AIF) from mitochondria. AIF, following nuclear translocation, stimulated endonucleases, resulting in cell death by Parthanatos. Human ARH3-deficiency is autosomal recessive, rare, and characterized by neurodegeneration and early death. Arh3-KO mice developed increased brain infarction following ischemia-reperfusion injury, which was reduced by PARP inhibitors. Similarly, PARP inhibitors improved survival of Arh3-KO cells treated with H2O2. ARH2 protein did not show activity in the in vitro assays described above for ARH1 and ARH3. ARH2 has a restricted tissue distribution, with primary involvement of cardiac and skeletal muscle. Overall, the ARH family has unique functions in biological processes and different enzymatic activities.

DOI： 10.3390/cells11233853

PubMed

researchmap
Accurate estimation of skeletal muscle mass by comparison of computed tomographic images of the third lumbar and third cervical vertebrae in Japanese patients with oral squamous cell carcinoma.

Nobuhide Ohashi, Kazushige Koike, Kurumi Sakai, Koyo Nishiyama, Takanori Sasaki, Kazuhiro Ogi, Hironari Dehari, Nobumichi Kobayashi, Akihiro Miyazaki

Oral radiology 39 ( 2 ) 408 - 417 2022年9月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: We evaluated the accuracy of estimating the cross-sectional area (CSA) at the third lumbar vertebra (L3) based on the CSA at the third cervical vertebra (C3) using computed tomographic images, and we identified the sources of error and bias using the evaluation of absolute reliability in 89 Japanese patients with oral squamous cell carcinoma. METHODS: Skeletal muscle CSA was measured at the C3 and L3 on pretreatment computed tomographic images. We used the CSA at the C3 to estimate CSA at the L3 in an existing prediction formula. Correlation coefficients were used to evaluate the relative reliability of the estimate, and Bland-Altman analysis and minimum detectable change (MDC) were used to evaluate its absolute reliability. RESULTS: Estimated and actual CSAs at L3 were strongly correlated (r = 0.885, p < 0.001). The mean difference between the estimated and actual CSAs was - 1.0887 cm2, the 95% confidence interval was - 4.09 to 1.91 cm2 (p = 0.472), and the 95% limits of agreement were - 29.0 and 26.8 cm2. The MDC at the 95% level of confidence in estimated and actual CSAs was 27.9 cm2. CONCLUSIONS: The estimation of CSA at the L3 from the existing prediction formula with the CSA at the C3 had no systematic biases, but it did have random errors. Random errors resulted from measurement errors and biological variation. Usefulness of the existing formula is limited by physical differences in populations.

DOI： 10.1007/s11282-022-00653-8

PubMed

researchmap
Clinical and histopathological effects of neoadjuvant intra-arterial chemoradiotherapy with cisplatin in combination with oral S-1 on stage III and IV oral cancer 国際誌

Kazushige Koike, Nobuhide Ohashi, Koyo Nishiyama, Junya Okamoto, Takanori Sasaki, Kazuhiro Ogi, Hironari Dehari, Naoki Hirokawa, Masanori Someya, Masato Saito, Hiroki Okuda, Akemi Otani, Tomoko Sonoda, Taro Sugawara, Tadashi Hasegawa, Hiroyoshi Hiratsuka, Koh-Ichi Sakata, Akihiro Miyazaki

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 134 ( 3 ) 347 - 353 2022年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: The aim of this study was to examine the clinical and histopathologic effects of neoadjuvant intra-arterial chemoradiotherapy (IACRT) using cisplatin in combination with oral S-1 (tegafur/gimeracil/oteracil potassium) on stage III and IV oral squamous cell carcinoma. STUDY DESIGN: Thirty patients received infusions of superselective intra-arterial cisplatin 60 mg/m2 by the Seldinger method and conventional external beam radiotherapy (total 40 Gy) combined with oral S-1 on the day of irradiation. Curative surgery and neck dissection were performed 4 to 6 weeks after IACRT. The clinical response of the primary lesion was evaluated approximately 4 weeks after IACRT. The surgically resected specimens were examined for histologic features according to the grading system for histologic evaluation and for residual tumor grade (RGrades). RESULTS: Histopathologic evaluation of the therapeutic effect was grade 2 in 10 patients and grade 3 in 16 patients. According to the distribution of RGrades, the remaining tumor cells were mostly in the central area of the primary lesion, as seen in 24 patients. CONCLUSIONS: These findings indicate that neoadjuvant IACRT with cisplatin and oral S-1 was an effective treatment, suggesting the possibility of reducing the extent of curative surgery based on RGrades.

DOI： 10.1016/j.oooo.2022.04.042

PubMed

researchmap
口腔扁平上皮癌におけるHLA class Ⅰの発現に関する予後因子としての有用性の検討

札幌医学雑誌 90 ( 1-6 ) 66 - 67 2022年3月

　詳細を見る

researchmap
Prognostic Value of CD45Ro+ T-Cell Expression in Patients With Oral Squamous Cell Carcinoma. 国際誌

Kazushige Koike, Koyo Nishiyama, Hironari Dehari, Kazuhiro Ogi, Takanori Sasaki, Shota Shimizu, Takashi Sasaya, Kei Tsuchihashi, Tomoko Sonoda, Tadashi Hasegawa, Hiroyoshi Hiratsuka, Akihiro Miyazaki

Anticancer research 41 ( 9 ) 4515 - 4522 2021年9月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: The role of tumour-infiltrating CD45Ro+ T-cells in oral squamous cell carcinoma (OSCC) is unclear. This study aimed to evaluate prognostic biomarkers for OSCC. PATIENTS AND METHODS: We determined the density of tumour-infiltrating CD45Ro+ T cells in the parenchyma and stroma at the tumour centre (TCe) and invasive front (IF) and examined the association between the density of these cells and histopathological status in 142 patients. RESULTS: Five-year overall survival (OS) and recurrence-free survival were favourable in patients with high CD45Ro+ T-cell density in the TCe stroma. OS was favourable in patients with high CD45Ro+ T-cell density in the IF stroma. Stepwise Cox regression model analysis indicated that CD45Ro+ T-cells in the stroma of the IF and TCe were an independent prognostic factor for OS. CONCLUSION: CD45Ro+ T-cells in the stroma of the IF and TCe play a role in cancer immune surveillance and may be a useful prognostic factor.

DOI： 10.21873/anticanres.15262

PubMed

researchmap
口腔扁平上皮癌におけるHLA class Iの発現に関する予後因子としての有用性の検討

小池和茂, 出張裕也, 荻和弘, 西山廣陽, 井嶋翔吾, 宮崎晃亘

日本口腔科学会雑誌 70 ( 2 ) 114 - 114 2021年7月

　詳細を見る

記述言語：日本語出版者・発行元：(NPO)日本口腔科学会

医中誌

researchmap
A case of repeated recurrence of intravascular papillary endothelial hyperplasia arising in the lower lip: Reconstruction using a local flap for a partial defect

Kazushige Koike, Koyo Nishiyama, Kazuhiro Ogi, Hironari Dehari, Kei Tsuchihashi, Takashi Sasaya, Hirotaka Kato, Taro Sugawara, Tsukasa Tsuji, Tadashi Hasegawa, Akihiro Miyazaki

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 33 ( 3 ) 322 - 329 2021年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.ajoms.2020.12.012

Web of Science

researchmap
Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma. 国際誌

Kazushige Koike, Hironari Dehari, Shota Shimizu, Koyo Nishiyama, Tomoko Sonoda, Kazuhiro Ogi, Junichi Kobayashi, Takanori Sasaki, Takashi Sasaya, Kei Tsuchihashi, Tomohide Tsukahara, Tadashi Hasegawa, Toshihiko Torigoe, Hiroyoshi Hiratsuka, Akihiro Miyazaki

Cancer science 111 ( 5 ) 1491 - 1499 2020年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Human leukocyte antigen (HLA) class Ⅰ molecules play a central role in anticancer immunity, but their prognostic value in oral squamous cell carcinoma (OSCC) remains unclear. We examined HLA class I expression in 2 distinct tumor compartments, namely, the tumor center and invasive front, and evaluated the association between its expression pattern and histopathological status in 137 cases with OSCC. Human leukocyte antigen class Ⅰ expression was graded semiquantitatively as high, low, and negative. At the invasive front of the tumor, HLA class I expression was high in 72 cases (52.6%), low in 44 cases (32.1%), and negative in 21 cases (15.3%). The HLA class I expression in the tumor center was high in 48 cases (35.0%), low in 58 cases (42.4%), and negative in 31 cases (22.6%). The 5-year overall survival and disease-specific survival rates were good in cases with high HLA class I expression at the invasive front; however, there was no significant difference in survival based on HLA class I expression in the tumor center. In addition, high HLA class I expression was correlated with high CD8+ T cell density, whereas negative HLA class I expression was correlated with low CD8+ T cell density at the invasive front. These results suggest that it is easier for CD8+ T cells to recognize presented peptides in the case of high HLA class Ⅰ expression at the tumor invasive front and could be a prognostic factor for OSCC.

DOI： 10.1111/cas.14388

PubMed

researchmap
Chemotherapy after progression on nivolumab is essential for responders with genetic alterations of driver gene: Review of two recurrent/metastatic oral squamous cell carcinoma patients. 国際誌

Kazuhiro Ogi, Junichi Kobayashi, Takafumi Nakagaki, Junya Okamoto, Kazushige Koike, Naoki Hirokawa, Masanori Someya, Hiroki Sakamoto, Kohichi Takada, Takashi Tokino, Yasushi Sasaki, Hiroyoshi Hiratsuka, Akihiro Miyazaki

Oral oncology 102 104509 - 104509 2020年3月

　詳細を見る

記述言語：英語

DOI： 10.1016/j.oraloncology.2019.104509

PubMed

researchmap
Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma. 国際誌

Kazushige Koike, Hironari Dehari, Kazuhiro Ogi, Shota Shimizu, Koyo Nishiyama, Tomoko Sonoda, Takanori Sasaki, Takashi Sasaya, Kei Tsuchihashi, Tadashi Hasegawa, Toshihiko Torigoe, Hiroyoshi Hiratsuka, Akihiro Miyazaki

PloS one 15 ( 8 ) e0237465 2020年

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Tumor-infiltrating lymphocytes include tumor-reactive lymphocytes and regulatory T-cells. However, the prognostic value of tumor-infiltrating lymphocytes in oral squamous cell carcinoma (OSCC) remains unclear. METHODS: We used immunohistochemistry to evaluate the presence of tumor-infiltrating FoxP3⁺ T-cells and CTLA-4⁺ cells in four distinct histological compartments (tumor parenchyma and stroma at the tumor center, and parenchyma and stroma at the invasive front) and assessed the association between the prevalence of these cells and the histopathological status of 137 patients with OSCC. RESULTS: Five-year overall survival, disease-specific survival, and recurrence-free survival were favorable in patients with high numbers of FoxP3⁺ T-cells in the parenchyma of the invasive front. Recurrence-free survival and metastasis-free survival were decreased in patients with high numbers of CTLA-4⁺ cells in the parenchyma of the invasive front. CONCLUSIONS: The presence of FoxP3⁺ T-cells in the parenchyma of the invasive front may be a useful prognostic factor. Our results indicate that FoxP3⁺ T-cells may exert site-specific anti-tumor effects but may not play an immunosuppressive role in OSCC. In addition, our results suggest that CTLA-4+ cells suppress the function of FoxP3+ T-cells and promote anti-tumor immunity in OSCC.

DOI： 10.1371/journal.pone.0237465

PubMed

researchmap
Tumor-infiltrating CD8+ T-cell density is an independent prognostic marker for oral squamous cell carcinoma. 国際誌

Shota Shimizu, Hiroyoshi Hiratsuka, Kazushige Koike, Kei Tsuchihashi, Tomoko Sonoda, Kazuhiro Ogi, Akira Miyakawa, Junichi Kobayashi, Takeshi Kaneko, Tomohiro Igarashi, Tadashi Hasegawa, Akihiro Miyazaki

Cancer medicine 8 ( 1 ) 80 - 93 2019年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The presence of tumor-infiltrating lymphocytes (TILs) is associated with improved survival in head and neck squamous cell carcinoma. However, the prognostic value of TILs remains unclear in oral squamous cell carcinoma (OSCC). METHODS: We evaluated the associations between tumor-infiltrating CD8+ T-cell density and survival in five distinct compartments in 139 OSCC cases. RESULTS: There was a significant association between increased tumor-infiltrating CD8+ T cells and their distribution. High parenchymal CD8+ T-cell density at the invading tumor edge was associated with improved overall survival (OS) and disease-specific survival (DSS; P < 0.01 and P < 0.01, respectively). High stromal CD8+ T-cell density at the tumor periphery was also associated with improved recurrence-free survival (RFS; P < 0.01). Cox regression analysis revealed that high stromal CD8+ T-cell density at the tumor periphery and high parenchymal CD8+ T-cell density at the invading edge were independent prognostic makers (hazard ratio: 0.38 and 0.19, 95% confidence interval, 0.18-0.80 and 0.05-0.72, P = 0.01 and 0.01, respectively) for RFS and OS, respectively. CONCLUSIONS: Assessment of CD8+ T cells at the parenchyma of the invading edge and peripheral stroma provides an indicator of tumor recurrence and prognosis.

DOI： 10.1002/cam4.1889

PubMed

researchmap
Tumor budding is an independent prognostic marker in early stage oral squamous cell carcinoma: With special reference to the mode of invasion and worst pattern of invasion. 国際誌

Shota Shimizu, Akihiro Miyazaki, Tomoko Sonoda, Kazushige Koike, Kazuhiro Ogi, Jun-Ichi Kobayashi, Takeshi Kaneko, Tomohiro Igarashi, Megumi Ueda, Hironari Dehari, Akira Miyakawa, Tadashi Hasegawa, Hiroyoshi Hiratsuka

PloS one 13 ( 4 ) e0195451 2018年

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Pathologically proven regional lymph node metastasis affects the prognosis in early stage oral cancer. Therefore we investigated invasive tumor patterns predicting nodal involvement and survival in patients with clinically node-negative T1 and T2 oral squamous cell carcinoma (cT1,2N0M0 OSCC). Ninety-one cases of cT1,2N0M0 OSCC treated with transoral resection of the primary tumor were assessed based on 3 types of invasive tumor patterns on histopathologic and pancytokeratin-stained immunohistological sections: the mode of invasion, worst pattern of invasion (WPOI), and tumor budding. The correlations among invasive tumor patterns, regional metastasis, and disease-free survival were analyzed. Of the 91 cases, 22 (24%) had pathologically proven regional metastasis. The mode of invasion (p<0.01) and tumor budding (p<0.01) were associated with regional metastasis as well as lymphovascular invasion (p = 0.04) in univariate analysis. In logistic regression analysis, however, tumor budding was the only independent predictor of regional metastasis (hazard ratio (HR) = 3.05, 95% confidence interval (CI) = 0.29-5.30, p<0.01). All three invasive patterns, the mode of invasion, WPOI, and tumor budding, were found to be significant predictors of 5-year disease-free survival (p<0.01, p = 0.03, and p<0.01, respectively) as well as lymphovascular invasion (p = 0.02) and perineural invasion (p = 0.02). A final model for Cox multivariate analysis identified the prognostic advantage of the intensity of tumor budding (HR = 2.19, 95% CI = 1.51-3.18, p<0.01) compared with the mode of invasion and WPOI in disease-free survival. Our results indicate that the intensity of tumor budding may be a novel diagnostic biomarker, as well as a therapeutic tool, for regional metastasis in patients with cT1,2N0M0 OSCC. If the pancytokeratin-based immunohistochemical features of more than five buds, and a grade 4C or 4D mode of invasion are identified, careful wait-and-see follow-up in a short period with the use of imaging modalities is desirable. If there are more than ten buds, a grade 4D mode of invasion, or WPOI-5 in the same section, wide resection of the primary tumor with elective neck dissection should be recommended.

DOI： 10.1371/journal.pone.0195451

PubMed

researchmap

▼全件表示

MISC

急性骨髄性白血病に随伴して上顎骨骨髄炎をきたしたムーコル症の1例

杉原真依, 南田秀之, 岡庭楓, 小池和茂, 宮崎晃亘

函館医学誌 49 ( 1 ) 72 - 77 2025年10月

　詳細を見る

記述言語：日本語出版者・発行元：市立函館病院

その他リンク:： https://search.jamas.or.jp/default/link?pub_year=2025&ichushi_jid=J01247&link_issn=&doc_id=20251226280012&doc_link_id=https%3A%2F%2Fsapmed.repo.nii.ac.jp%2Frecords%2F2000945&url=https%3A%2F%2Fsapmed.repo.nii.ac.jp%2Frecords%2F2000945&type=%E6%9C%AD%E5%B9%8C%E5%8C%BB%E7%A7%91%E5%A4%A7%E5%AD%A6%EF%BC%9A%E6%9C%AD%E5%B9%8C%E5%8C%BB%E7%A7%91%E5%A4%A7%E5%AD%A6%E5%AD%A6%E8%A1%93%E6%A9%9F%E9%96%A2%E3%83%AA%E3%83%9D%E3%82%B8%E3%83%88%E3%83%AA_ikor&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80183_3.gif

医中誌

researchmap
腎摘除術後15年目に上顎歯肉に孤立性転移をきたした腎細胞癌の1例

林恵[土橋], 宮崎晃亘, 佐々木敬則, 杉原真依, 杉田真太朗, 小池和茂

日本口腔外科学会雑誌 71 ( 10 ) 477 - 483 2025年10月

　詳細を見る

記述言語：日本語出版者・発行元：(公社)日本口腔外科学会

医中誌

researchmap
口腔扁平上皮癌におけるHLA class Iの発現に関する予後因子としての有用性の検討

小池和茂, 出張裕也, 荻和弘, 西山廣陽, 井嶋翔吾, 宮崎晃亘

日本口腔科学会雑誌 70 ( 2 ) 114 - 114 2021年7月

　詳細を見る

記述言語：日本語出版者・発行元：(NPO)日本口腔科学会

医中誌

researchmap
パーキンソン病を合併した習慣性顎関節脱臼の1例

島西真琴, 出張裕也, 小池和茂

王子総合病院医学雑誌 ( 11 ) 27 - 29 2021年7月

　詳細を見る

記述言語：日本語出版者・発行元：(医)王子総合病院

医中誌

researchmap
頬部に発生した孤立性神経線維腫の1例

宮城了三, 土橋恵, 畠中柚衣, 小池和茂, 宮崎晃亘

日本口腔診断学会雑誌 34 ( 2 ) 117 - 122 2021年6月

　詳細を見る

記述言語：日本語出版者・発行元：(一社)日本口腔診断学会

医中誌

researchmap
Stage III・IVの口腔扁平上皮癌に対する動注化学療法併用放射線治療の治療効果に関する検討

小池和茂, 岡本準也, 西山廣陽, 佐々木敬則, 荻和弘, 出張裕也, 宮崎晃亘

頭頸部癌 47 ( 2 ) 2021年

　詳細を見る

J-GLOBAL

researchmap
口腔癌患者における免疫担当細胞の発現と予後との関連性についての検討

小池和茂, 西山廣陽, 出張裕也, 荻和弘

日本癌学会学術総会抄録集(Web) 80th 2021年

　詳細を見る

J-GLOBAL

researchmap
頭頸部扁平上皮がんの腫瘍微小環境におけるAEBP1の解析

関口翔平, 関口翔平, 萬顕, 山本英一郎, 山本英一郎, 新沼猛, 高澤啓, 高澤啓, 須藤豪太, 須藤豪太, 小池和茂, 畠中柚衣, 畠中柚衣, 吉戸文乃, 北嶋洋志, 甲斐正広, 小山内誠, 小山内誠, 高野賢一, 宮崎晃亘, 鈴木拓

日本癌学会学術総会抄録集(Web) 80th 2021年

　詳細を見る

J-GLOBAL

researchmap
新人看護師に対する口腔ケア研修の効果について

千本木瑶子, 島西真琴, 出張裕也, 宮崎晃亘, 小池和茂, 吉田友和

日本口腔ケア学会雑誌 14 ( 3 ) 167 - 167 2020年9月

　詳細を見る

記述言語：日本語出版者・発行元：(一社)日本口腔ケア学会

医中誌

researchmap
当院における周術期等口腔機能管理の臨床統計的検討

上野智史, 小池和茂, 土橋恵, 笹谷聖, 西山廣陽, 大西みちよ, 中井裕美, 上田愛, 佐々木敬則, 三木善樹, 高橋ゆかり, 水野愛理, 種村理絵子, 荻和弘, 出張裕也, 宮崎晃亘

日本口腔ケア学会雑誌 14 ( 3 ) 199 - 199 2020年9月

　詳細を見る

記述言語：日本語出版者・発行元：(一社)日本口腔ケア学会

医中誌

researchmap
口腔扁平上皮癌におけるCD8+ T細胞,FoxP3+ T細胞,CTLA-4+細胞の発現に関する免疫組織化学的検討

小池和茂, 出張裕也, 西山廣陽, 都倉尭明, 荻和弘, 宮崎晃亘

日本口腔科学会学術集会プログラム・抄録集 74th 2020年

　詳細を見る

J-GLOBAL

researchmap
口腔癌に対する免疫療法:個別化・複合免疫療法の臨床応用に向けての研究

宮崎晃亘, 荻和弘, 小池和茂, 岡本準也, 出張裕也, 中井裕美

月刊Precision Medicine 3 ( 14 ) 2020年

　詳細を見る

J-GLOBAL

researchmap
再発または遠隔転移を有する口腔癌に対しニボルマブ投与は遺伝子変異が指標となるか

荻和弘, 小林淳一, 小林淳一, 西山廣陽, 小池和茂, 高田弘一, 染谷正則, 宮崎晃亘

日本癌治療学会学術集会(Web) 58th 2020年

　詳細を見る

J-GLOBAL

researchmap
口腔扁平上皮癌におけるHLA class Ι発現の予後に与える影響とCD8+T細胞密度との関連性

小池和茂, 出張裕也, 西山廣陽, 荻和弘, 笹谷聖, 土橋恵, 畠中柚衣, 畠中柚衣, 塚原智英, 鳥越俊彦, 宮崎晃亘

日本癌学会学術総会抄録集(Web) 79th 863 - 863 2020年

　詳細を見る

記述言語：英語掲載種別：研究発表ペーパー・要旨（国際会議）

Web of Science

J-GLOBAL

researchmap
舌癌の術前または根治的な動注化学放射線療法の成績-少動注量・少放射線量の局所治療効果を含めて-

廣川直樹, 齋藤正人, 奥田洋輝, 池内佑太朗, 大谷緋美, 坂田耕一, 小池和茂, 小林淳一, 五十嵐友彦, 宮崎晃亘

日本医学放射線学会秋季臨床大会抄録集 55th 2019年

　詳細を見る

J-GLOBAL

researchmap
口腔扁平上皮癌における制御性T細胞の発現に関する免疫組織化学的検討

小池和茂, 出張裕也, 荻和弘, 清水翔太, 小林淳一, 西山廣陽, 土橋恵, 畠中柚衣, 宮崎晃亘

日本癌学会学術総会抄録集(Web) 78th 2019年

　詳細を見る

J-GLOBAL

researchmap
口腔扁平上皮癌における制御性T細胞の発現に関する免疫組織化学的検討

小池和茂, 清水翔太, 荻和弘, 都倉尭明, 西山廣陽, 宮崎晃亘

日本口腔科学会学術集会プログラム・抄録集 73rd 2019年

　詳細を見る

J-GLOBAL

researchmap
CDDPを用いた動注化学放射線療法により腫瘍が消失した口腔扁平上皮癌の検討

金子剛, 小林淳一, 宮崎晃亘, 小池和茂, 清水翔太, 平塚博義

日本口腔腫瘍学会総会・学術大会プログラム・抄録集 36th 2018年

　詳細を見る

J-GLOBAL

researchmap
FDG-PET/CTで集積亢進を示した口底神経鞘腫の1例

金子剛, 宮崎晃亘, 小林淳一, 清水翔太, 小池和茂, 平塚博義

日本口腔外科学会雑誌 64 ( 5 ) 2018年

　詳細を見る

J-GLOBAL

researchmap
当科における下顎骨骨折の臨床的検討

小池和茂, 宮崎晃亘, 平塚博義

口腔顎顔面外傷 16 ( 2 ) 2017年

　詳細を見る

J-GLOBAL

researchmap
当科における過去5年間の小児口腔顎顔面外傷200例の臨床的検討

岡本準也, 宮崎晃亘, 小池和茂, 出張裕也, 小林淳一, 平塚博義

口腔顎顔面外傷 16 ( 2 ) 2017年

　詳細を見る

J-GLOBAL

researchmap
Hemifacial microsomia患者における顎顔面形態の定量的分析

都倉尭明, 宮崎晃亘, 荻和弘, 西山廣陽, 小池和茂, 坂本結生, 中垣貴文, 五十嵐友彦, 出張裕也, 平塚博義

日本口腔科学会学術集会プログラム・抄録集 71st 2017年

　詳細を見る

J-GLOBAL

researchmap
下顎関節突起骨折96例の臨床的検討

小池和茂, 宮崎晃亘, 佐々木敬則, 都倉尭明, 西山廣陽, 島西真琴, 荻和弘, 平塚博義

日本口腔科学会学術集会プログラム・抄録集 70th 2016年

　詳細を見る

J-GLOBAL

researchmap

▼全件表示

受賞

若手口腔外科医優秀論文賞

2021年11月日本口腔外科学会 Prognostic value of HLA class I in patients with oral squamous cell carcinoma

　詳細を見る

researchmap
Rising Scientist賞

2021年5月第75回日本口腔科学会学術集会口腔扁平上皮癌におけるHLA classIの発現に関する予後因子としての有用性の検討

　詳細を見る

researchmap

共同研究・競争的資金等の研究課題

口腔癌における腫瘍微小環境の解明と治療への応用

研究課題/領域番号：26K20341 2026年4月 - 2029年3月

日本学術振興会科学研究費助成事業若手研究

小池和茂

　詳細を見る

配分額：4160000円（直接経費：3200000円、間接経費：960000円）

researchmap
口腔癌における予後因子の同定および癌増殖局所の機能分子を標的とした治療法の開発

研究課題/領域番号：20K18675 2025年1月 - 2026年3月

日本学術振興会科学研究費助成事業若手研究

小池和茂

　詳細を見る

配分額：3250000円（直接経費：2500000円、間接経費：750000円）

本研究は、口腔扁平上皮癌(OSCC)増殖局所の微小環境における腫瘍浸潤リンパ球(TIL)の実態、発育先進部の簇出、上皮-間葉移行(EMT)の発現、分子生物学的解析を行うことで、臨床病理学的因子との相互関係を解明し治療への応用を目的とする基礎的研究である。
これまでの主な研究の成果として、口腔扁平上皮癌において腫瘍浸潤先端部(IF)のHLA class Ⅰの発現レベルは実臨床で使用できる有用な予後予測因子となり得ることを明らかにした。(Cancer Sci. 2020)
またその他にもIFの実質におけるFoxP3陽性T細胞の発現が有用な予後因子であることが示され、また、OSCCにおいてはFoxP3陽性T細胞は制御性T細胞としての機能を有していない可能性があり、CTLA-4陽性細胞がFoxP3陽性T細胞の機能を抑制していることを明らかにした。(PLoS ONE. 2020)
本年度も引き続きTILの発現に着目し、IFと腫瘍中心部(TCe)の間質に存在するCD45Ro+T細胞が、癌免疫監視機構において重要な役割を担っており、予後予測因子として有用である可能性を示した。(Anticancer Res. 2021)
上記のように予後因子を明らかにすることで、今後確度の高い術後フォローアップ体制を確立することが可能になるものと考えている。また免疫逃避機構の解明だけではなく、化学療法に癌ペプチドワクチンや免疫チェックポイント阻害薬を組み合わせた複合免疫療法の開発に応用できると考えている。
2022年2月より海外留学のため研究を中断することとなったため、帰国後に本研究を完遂させる予定である。

researchmap
口腔癌における予後因子の同定および癌増殖局所の機能分子を標的とした治療法の開発

研究課題/領域番号：20K18675 2020年4月 - 2022年3月

日本学術振興会科学研究費助成事業若手研究若手研究

小池和茂

　詳細を見る

配分額：3250000円（直接経費：2500000円、間接経費：750000円）

本研究は、口腔扁平上皮癌(OSCC)増殖局所の微小環境における腫瘍浸潤リンパ球(TIL)の実態、発育先進部の簇出、上皮-間葉移行(EMT)の発現、分子生物学的解析を行うことで、臨床病理学的因子との相互関係を解明し治療への応用を目的とする基礎的研究である。
これまでの主な研究の成果として、口腔扁平上皮癌において腫瘍浸潤先端部(IF)のHLA class Ⅰの発現レベルは実臨床で使用できる有用な予後予測因子となり得ることを明らかにした。(Cancer Sci. 2020)
またその他にもIFの実質におけるFoxP3陽性T細胞の発現が有用な予後因子であることが示され、また、OSCCにおいてはFoxP3陽性T細胞は制御性T細胞としての機能を有していない可能性があり、CTLA-4陽性細胞がFoxP3陽性T細胞の機能を抑制していることを明らかにした。(PLoS ONE. 2020)
本年度も引き続きTILの発現に着目し、IFと腫瘍中心部(TCe)の間質に存在するCD45Ro+T細胞が、癌免疫監視機構において重要な役割を担っており、予後予測因子として有用である可能性を示した。(Anticancer Res. 2021)
上記のように予後因子を明らかにすることで、今後確度の高い術後フォローアップ体制を確立することが可能になるものと考えている。また免疫逃避機構の解明だけではなく、化学療法に癌ペプチドワクチンや免疫チェックポイント阻害薬を組み合わせた複合免疫療法の開発に応用できると考えている。
2022年2月より海外留学のため研究を中断することとなったため、帰国後に本研究を完遂させる予定である。

researchmap

その他

口腔外科学会認定医

　詳細を見る

researchmap
臨床研修指導歯科医

　詳細を見る

researchmap