Updated on 2026/08/08

写真a

 
SHIMADA Hiroshi
 
Organization
School of Medicine Department of Obstetrics and Gynecology Assistant Professor
Title
Assistant Professor
ORCID ID
0000-0002-4049-6376
External link

Degree

  • Doctor of Philosophy ( 2016.3   Sapporo Medical University )

Research Interests

  • トロホブラスト、胎児発育、胎盤栄養輸送

Research Areas

  • Life Science / Cell biology  / cellular tight junction, endometrioid adenocarcinoma

  • Life Science / Obstetrics and gynecology  / 胎児超音波診断学

  • Life Science / Obstetrics and gynecology  / fetal grwoth, maternal-fetal exchange, syncytiotrophoblast, fetal development

Education

  • 札幌医科大学大学院

    2012.4 - 2016.3

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    Country： Japan

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  • Sapporo Medical University

    2004.4 - 2010.3

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    Country： Japan

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Research History

  • Sapporo Medical University   Department of Obstetrics and Gynecology   Assistant Professor

    2025.8

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    Country：Japan

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  • University of Colorado, Anschutz Medical Campus, Aurora, CO, US   Department of Obstetrics and Gynecology   Volunteer post doctoral fellow

    2023.9 - 2025.7

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  • Nikko Memorial Hospital

    2019.4 - 2023.8

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Papers

  • Regulation of placental amino acid transport in health and disease International journal

    Hiroshi Shimada, Theresa L. Powell, Thomas Jansson

    Acta Physiologica   240 ( 7 )   e14157   2024.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    Abnormal fetal growth, i.e., intrauterine growth restriction (IUGR) or fetal growth restriction (FGR) and fetal overgrowth, is associated with increased perinatal morbidity and mortality and is strongly linked to the development of metabolic and cardiovascular disease in childhood and later in life. Emerging evidence suggests that changes in placental amino acid transport may contribute to abnormal fetal growth. This review is focused on amino acid transport in the human placenta, however, relevant animal models will be discussed to add mechanistic insights. At least 25 distinct amino acid transporters with different characteristics and substrate preferences have been identified in the human placenta. Of these, System A, transporting neutral nonessential amino acids, and System L, mediating the transport of essential amino acids, have been studied in some detail. Importantly, decreased placental Systems A and L transporter activity is strongly associated with IUGR and increased placental activity of these two amino acid transporters has been linked to fetal overgrowth in human pregnancy. An array of factors in the maternal circulation, including insulin, IGF-1, and adiponectin, and placental signaling pathways such as mTOR, have been identified as key regulators of placental Systems A and L. Studies using trophoblast-specific gene targeting in mice have provided compelling evidence that changes in placental Systems A and L are mechanistically linked to altered fetal growth. It is possible that targeting specific placental amino acid transporters or their upstream regulators represents a novel intervention to alleviate the short- and long-term consequences of abnormal fetal growth in the future.

    DOI： 10.1111/apha.14157

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  • The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma

    Hiroshi Shimada, Takayuki Kohno, Takumi Konno, Tadahi Okada, Kimihito Saito, Yuma Shindo, Shin Kikuchi, Mitsuhiro Tsujiwaki, Marie Ogawa, Motoki Matsuura, Tsuyoshi Saito, Takashi Kojima

    Cancers   2021

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/cancers13246341

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  • Sexual Dimorphism in Placental mTORC1 Signaling, Amino Acid Transport, and Mitochondrial Respiration at Term

    Hiroshi Shimada, Toshihide Sakuragi, Vincent Zaegel, Anita Kramer, Kristen E. Boyle, Theresa L. Powell, Thomas Jansson, Fredrick J. Rosario

    Antioxidants   2026.8

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/antiox15080977

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  • Trophoblast-specific overexpression of Slc7a5 increases fetal amino acid availability and hepatic mTOR signalling and causes increased fetal growth. International journal

    Fredrick J Rosario, Hiroshi Shimada, Sam Blessen J Fredrick, Kenneth Barentsen, Theresa L Powell, Johann Urschitz, Thomas L Brown, Laura Brown, Thomas Jansson

    The Journal of physiology   2026.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Abnormal fetal growth is linked to perinatal complications and increased risk of metabolic and cardiovascular diseases, yet the underlying mechanisms remain unclear. Placental System L amino acid transport is decreased in human pregnancies complicated by fetal growth restriction and increased in fetal overgrowth. We previously demonstrated that trophoblast-specific overexpression (OX) of Slc7a5/LAT1 enhances transplacental leucine transport and fetal growth. However, the mechanistic link between increased placental transfer of leucine and stimulation of fetal growth remains unclear. We hypothesized that trophoblast-specific Slc7a5 OX in mice increases fetal plasma levels of essential amino acids, which are associated with elevated fetal circulating levels of insulin and IGF-1 and activation of fetal liver insulin/IGF-1 and mTOR signalling. Trophoblast-specific Slc7a5 OX in mice was generated by lentiviral transduction of embryonic day (E) 3.5 mouse blastocysts followed by embryo transfer. Maternal and pooled fetal plasma samples and fetal livers were collected at E18.5. Slc7a5 OX significantly increased fetal weight and fetal plasma levels of essential amino acids, including leucine, phenylalanine, tryptophan, lysine, histidine, valine, methionine and isoleucine. Insulin and IGF-1 concentrations were elevated in fetal plasma, and fetal liver showed an increased phosphorylation of p70S6K1-Threonine-389, S6-Serine-235/236 and Akt-Serine-473, indicating activation of insulin/IGF-1 and mTORC1 and mTORC2 pathways. These results support the hypothesis that placental LAT1 overexpression enhances fetal amino acid supply, driving endocrine responses and anabolic signalling that promote accelerated fetal growth. We speculate that targeting placental LAT1 may represent a novel intervention in cases of pathological fetal growth. KEY POINTS: Placental amino acid transport is critical for fetal growth and serves as a link between maternal nutrition, placental function and fetal development. Trophoblast-specific overexpression of Slc7a5 (LAT1) in mice increases placental transport of essential amino acids, including leucine and lysine. Fetal plasma amino acids, insulin and IGF-1 concentrations were elevated following LAT1 overexpression. Fetal hepatic signalling was activated, with increased mTORC1 (p-S6 Ser235/236) and mTORC2 (p-Akt Ser473) phosphorylation, while Akt Thr308 phosphorylation was unaffected. Fetuses exposed to LAT1 overexpression were larger, with increased fetal and placental weights, consistent with a fetal overgrowth phenotype. These findings demonstrate that placental LAT1 functions as a nutrient-sensing regulator of fetal growth via endocrine and metabolic signalling pathways.

    DOI： 10.1113/JP289970

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  • Placental mitochondrial respiration is inhibited in mice with trophoblast specific AdipoR2 overexpression. International journal

    Hiroshi Shimada, Toshihide Sakuragi, Kenneth Barentsen, Kathryn Erickson, Johann Urschitz, Theresa L Powell, Thomas Jansson, Fredrick J Rosario

    Free radical biology & medicine   2025.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    Maternal circulating levels of adiponectin are inversely correlated with fetal growth mediated by its effect on placental function. The cellular effects of adiponectin on trophoblast are mainly mediated by adiponectin receptor isoform 2 (AdipoR2,) resulting in the activation of PPARα and synthesis of ceramides, which inhibit insulin and mTOR signaling. We have recently demonstrated that trophoblast-specific overexpression of AdipoR2 in pregnant mice inhibits placental mTORC1 signaling and nutrient transport, resulting in fetal growth restriction. Trophoblast mTORC1 signaling is a positive regulator of mitochondrial respiration. However, it is unknown if placental adiponectin signaling is mechanistically linked to mitochondrial function. We hypothesized that trophoblast-specific overexpression of AdipoR2 in pregnant mice decreases placental oxidative phosphorylation. At Embryonic day (E) 3.5, blastocysts from super-ovulated, time-mated B6D2F1 female mice were collected and transduced with lentivirus constructs for AdipoR2-overexpression (AdipoR2-OX) or scramble (SCR) sequences. The blastocysts were surgically transferred to pseudo-pregnant CD-1 recipient dams. Following euthanasia at E18.5, we separated the labyrinth and the junctional zone. In the labyrinth, AdipoR2 overexpression significantly inhibited placental mitochondrial GMPP respiration as determined by high-resolution respirometry. Moreover, placental AdiopoR2-OX decreased GLUD1, TOM22 and PGC1α protein expression. In the junctional zone, we found no significant differences between control (SCR) and AdipoR2-OX groups. In conclusion, our data suggests that maternal adiponectin signaling in the trophoblast decreases placental mitochondrial respiration, specifically in the labyrinth zone. This effect is possibly mediated by inhibition of mTORC1 and decreased expression of PGC1α.

    DOI： 10.1016/j.freeradbiomed.2025.11.025

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  • Inducible Trophoblast-Specific Knockdown of Mechanistic Target of Rapamycin Impairs Placental Folate Transport in Mice. International journal

    Hiroshi Shimada, Johann Urschitz, Theresa L Powell, Thomas Jansson, Fredrick J Rosario

    The Journal of nutritional biochemistry   110189 - 110189   2025.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    Folate deficiency in pregnancy is strongly associated with fetal growth restriction (FGR). Fetal folate availability is determined by maternal folate intake and the capacity of the placenta to transport folate. However, the mechanisms regulating placental folate transport remain poorly understood. The mechanistic target of rapamycin (mTOR) regulates placental function and fetal growth, but it is unknown if mTOR regulates folate transport in vivo. We hypothesized that trophoblast-specific mTOR knockdown inhibits placental folate transport in mice. We generated transgenic mice with a doxycycline-inducible, trophoblast-specific Mtor knockdown using PiggyBac transposase-enhanced pronuclear injection. Doxycycline administration on embryonic day (E) 14.5 induced placental-specific Mtor knockdown, resulting in reduced fetal weight, placental weight, and fetal-to-placental weight ratio. Functionally, mTOR knockdown reduced folate uptake in isolated trophoblast plasma membranes (TPM), decreased the TPM protein expression of the three main placental folate transporters (FRα, RFC, and PCFT) without affecting protein expression of theses transporters in placental homogenates, and lowered fetal plasma folate concentration. In conclusion, mTOR signaling is a positive regulator of the three main placental folate transporters in vivo mediated by posttranslational mechanisms, likely involving effects of plasma membrane trafficking. Trophoblast mTOR signaling is essential for maintaining adequate fetal folate supply and we propose that the inhibition of placental mTOR signaling reported in FGR contributes to fetal folate deficiency and decreased fetal growth in this pregnancy complication. Our data supports the potential to target placental mTOR signaling as a novel intervention in pregnancies affected by abnormal fetal growth.

    DOI： 10.1016/j.jnutbio.2025.110189

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  • Normalization of trophoblast mTOR signaling rescues impaired function in primary human trophoblast cells isolated from pregnancies complicated by fetal growth restriction. International journal

    Ellen C Francis, Hiroshi Shimada, Theresa L Powell, Kristen E Boyle, Dana Dabelea, Thomas Jansson, Fredrick J Rosario

    Cell death discovery   11 ( 1 )   513 - 513   2025.11

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    Fetal growth restriction (FGR) is associated with inhibition of placental mTOR signaling and amino acid transport. mTOR is a positive regulator of amino acid transport mediated by controlling the plasma membrane trafficking of SNAT2, a System A amino acid transporter isoform, and LAT1 an isoform involved in System L amino acid transport. Inhibition of mTOR complex 1 decreases SNAT2 and LAT1 plasma membrane trafficking by activating of Nedd4-2, an E3 ubiquitin ligase, and inhibition of mTOR Complex 2 decreases the protein expression of Cdc42 which limits transporter trafficking to the plasma membrane. We isolated human primary trophoblast (PHT) cells from FGR placentas and demonstrate that they maintain the in vivo FGR phenotype with increased expression of DEPTOR, an endogenous inhibitor of mTOR, reduced mTOR signaling, increased Nedd4-2 expression, lower expression of Cdc42, and decreased SNAT2 and LAT 1 protein expression in the plasma membrane, and decreased System A and L activity. We silenced DEPTOR in FGR PHT cells using siRNA and found normalized mTOR signaling, Nedd4-2 and Cdc42 protein expression, SNAT2 and LAT1 plasma membrane trafficking and System A and L amino acid transport activity. We also show that hypoxia induces DEPTOR upregulation in PHT cells. In the Healthy Start Study, a longitudinal pre-birth cohort, placental DEPTOR expression was correlated with lower birth weight percentile and with higher systolic and diastolic blood pressure in children at 4-6 years of age. Together, our studies provide mechanistic and translational insight into how placental DEPTOR may serve as potential mediator of fetal growth and long-term health risk. We identify a mechanistic link between increased trophoblast DEPTOR expression in FGR and decreased placental mTOR signaling and amino acid transport. Intervention strategies aimed at normalizing trophoblast mTOR signaling may be effective to improve trophoblast nutrient transport and fetal growth in FGR.

    DOI： 10.1038/s41420-025-02801-5

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  • The roles of tight junction protein cingulin in human endometrioid endometrial cancer. International journal

    Arisa Kura, Kimihito Saito, Takumi Konno, Takayuki Kohno, Hiroshi Shimada, Tadahi Okada, Soshi Nishida, Daichi Ishii, Motoki Matsuura, Tsuyoshi Saito, Takashi Kojima

    Tissue barriers   13 ( 2 )   2361976 - 2361976   2024.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    The bicellular tight junction molecule cingulin (CGN) binds to microtubules in centrosomes. Furthermore, CGN contributes to the tricellular tight junction (tTJ) proteins lipolysis-stimulated lipoprotein receptor (LSR) and tricellulin (TRIC). CGN as well as LSR decreased during the malignancy of endometrioid endometrial cancer (EEC). Although tTJ protein LSR is involved in the malignancy of some cancers, including EEC, the role of CGN is unknown. In this study, we investigated the roles of CGN with tTJ proteins in human EEC cells by using the CGN-overexpressing EEC cell line Sawano. In 2D cultures, CGN was colocalized with LSR and TRIC at tTJ or at γ-tubulin-positive centrosomes. In immunoprecipitation with CGN antibodies, CGN directly bound to LSR, TRIC, and β-tubulin. Knockdown of CGN by the siRNA decreased the epithelial barrier and enhanced cell proliferation, migration and invasion, as well as knockdown of LSR. In the Sawano cells cocultured with normal human endometrial stromal cells, knockdown of CGN decreased expression of LSR and TRIC via MAPK and AMPK pathways. In 2.5D cultures, knockdown of CGN induced the formation of abnormal cysts and increased the permeability of FD-4 to the lumen. In 2D and 2.5D cultures, treatment with β-estradiol with or without EGF or TGF-β decreased CGN expression and the epithelial permeability barrier and enhanced cell migration, and pretreatment with EW7197+AG1478, U0126 or an anti-IL-6 antibody prevented this. In conclusion, CGN, with tTJ proteins might suppress the malignancy of human EEC and its complex proteins are sensitive to estrogen and growth factors derived from stromal cells.

    DOI： 10.1080/21688370.2024.2361976

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  • The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line. International journal

    Takumi Konno, Takayuki Kohno, Shin Kikuchi, Arisa Kura, Kimihito Saito, Tadahi Okada, Hiroshi Shimada, Yuya Yamazaki, Tomoki Sugiyama, Motoki Matsuura, Yuki Ohsaki, Tsuyoshi Saito, Takashi Kojima

    Tissue barriers   2304443 - 2304443   2024.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    It is known that there are abnormalities of tight junction functions, cell migration and mitochondrial metabolism in human endometriosis and endometrial carcinoma. In this study, we investigated the effects of growth factors and their inhibitors on the epithelial permeability barrier, cell migration and mitochondrial metabolism in 2D and 2.5D cultures of human endometrioid endometrial carcinoma Sawano cells. We also investigated the changes of bicellular and tricellular tight junction molecules and ciliogenesis induced by these inhibitors. The growth factors TGF-β and EGF affected the epithelial permeability barrier, cell migration and expression of bicellular and tricellular tight junction molecules in 2D and 2.5D cultures of Sawano cells. EW-7197 (a TGF-β receptor inhibitor), AG1478 (an EGFR inhibitor) and SP600125 (a JNK inhibitor) affected the epithelial permeability barrier, cell migration and mitochondrial metabolism and prevented the changes induced by TGF-β and EGF in 2D and 2.5D cultures. EW-7197 and AG1478 induced ciliogenesis in 2.5D cultures. In conclusion, TGF-β and EGF promoted the malignancy of endometrial cancer via interplay among the epithelial permeability barrier, cell migration and mitochondrial metabolism. EW-7197 and AG1478 may be useful as novel therapeutic treatments options for endometrial cancer.

    DOI： 10.1080/21688370.2024.2304443

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  • Mailing human papillomavirus self-sampling kits to women under-screened for cervical cancer improved detection in cervical cancer screening in a general population study in Japan. International journal

    Yoko Nishimura, Motoki Matsuura, Noriko Terada, Sachiko Nagao, Hiroshi Shimada, Kyoko Isoyama, Masato Tamate, Masahiro Iwasaki, Tsuyoshi Saito

    BMC public health   23 ( 1 )   473 - 473   2023.3

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    BACKGROUND: One cause of the increase in cervical cancer rates in Japan is the long-term stagnation in the cervical cancer screening consultation rate. Therefore, improving the screening consultation rate is of urgent concern to reduce cervical cancer incidence. Self-collected human papilloma virus (HPV) tests have been successfully adopted in several countries, such as the Netherlands and Australia, as a measure of individuals who have not undergone cervical cancer screening in national programs. This study aimed to verify whether self-collected HPV tests presented an effective countermeasure for individuals who had not undergone the recommended cervical cancer screenings. METHODS: This study was conducted from December 2020 to September 2022 in Muroran City, Japan. The primary evaluated endpoint was the percentage of citizens who underwent cervical cancer screening at a hospital with positive self-collected HPV test results. The secondary endpoint was the percentage of included participants who were diagnosed with cervical intraepithelial neoplasia (CIN) or higher among those who visited a hospital and underwent cervical cancer screening. RESULTS: The included study participants were 7,653 individuals aged 20-50 years with no record of previous cervical cancer examination in the past 5 years. We mailed these participants information on self-administered HPV tests as an alternative screening procedure and sent the kit to 1,674 women who requested the test. Among them, 953 returned the kit. Among the 89 HPV-positive individuals (positive rate, 9.3%), 71 (79.8%) visited the designated hospital for an examination. A closer examination revealed that 13 women (18.3% of hospital visits) had a CIN finding of CIN2 or higher, among whom one each had cervical cancer and vulvar cancer, eight presented with CIN3, and three presented with CIN2; two cases of invasive gynecologic cancer were also identified. CONCLUSIONS: We conclude that the self-collected HPV tests showed a certain efficacy as a measure of individuals who had not undergone the recommended cervical cancer screening. We devised ways to have the unexamined patients undergo HPV testing and ensure that HPV-positive individuals visited the hospital. Despite a few limitations, our findings suggest the effectiveness of this public health intervention.

    DOI： 10.1186/s12889-023-15402-7

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  • Human papillomavirus testing and cytology using physician-collected uterine cervical samples vs. self-collected vaginal samples and urine samples.

    Noriko Terada, Motoki Matsuura, Shoko Kurokawa, Yoko Nishimura, Masato Tamate, Kyoko Isoyama, Satoko Yamazaki, Hiroshi Shimada, Masahiro Suzuki, Yuta Tabuchi, Mizue Teramoto, Tsuyoshi Saito

    International journal of clinical oncology   27 ( 11 )   1742 - 1749   2022.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Human papillomavirus (HPV) testing using self-collected vaginal samples and urine samples is convenient and effective for improving the screening rate. But, to serve as an alternative cervical cancer screening technique, such tests must offer sensitivity equivalent to the HPV testing of physician-collected cervical samples. To examine the effectiveness of HPV testing using self-collected samples and urine samples, we compared the results of HPV testing using these samples with those of HPV testing using physician-collected samples and cytological examinations. METHODS: The study population included 300 women (age: 20-50 years) with abnormal cervical cytology. The results of HPV testing using self-collected samples and urine samples and physician-collected samples and cervical cytology were compared. RESULTS: For all HPV types, the κ-value was 0.773 for physician- and self-collected samples and 0.575 for physician-collected and urine samples. The κ-value for HPV type 16-positive samples was 0.988 for physician- and self-collected samples and 0.896 for physician-collected and urine samples. The κ-value for HPV type 18-positive samples was 0.856 for physician- and self-collected samples and 0.831 for physician-collected and urine samples. For other HPV types, the value was 0.809 for physician- and self-collected samples and 0.617 for physician-collected and urine samples. CONCLUSIONS: The obtained results were consistent between physician- and self-collected samples as well as between physician-collected and urine samples. Considering that the agreement rate was particularly high for the high-risk HPV types 16 and 18, HPV testing using physician-collected samples, self-collected samples, and urine samples was equally effective for the types with high carcinogenicity.

    DOI： 10.1007/s10147-022-02238-1

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  • 巨大嚢胞化し、子宮留膿腫を繰り返した帝王切開瘢痕部症候群の1例

    仁木 舜一, 嶋田 浩志, 玉手 雅人, 杉山 芽, 今 沙織, 鈴木 美紀, 松浦 基樹, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   69回   112 - 112   2022.10

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    Language：Japanese   Publisher：東北連合産科婦人科学会・北日本産科婦人科学会  

    Ichushi

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  • LSR antibody promotes apoptosis and disrupts epithelial barriers via signal pathways in endometrial cancer

    Kimihito Saito, Takumi Konno, Takayuki Kohno, Hiroshi Shimada, Motoki Matsuura, Tadahi Okada, Arisa Kura, Daichi Ishii, Masuo Kondoh, Tsuyoshi Saito, Takashi Kojima

    Tissue Barriers   2022.7

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    Publishing type：Research paper (scientific journal)   Publisher：Informa {UK} Limited  

    DOI： 10.1080/21688370.2022.2106113

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  • Next-generation sequencing of 16S rRNA for identification of invasive bacterial pathogens in a formalin-fixed paraffin-embedded placental specimen: a case report of perinatal fulminant Streptococcus pyogenes infection.

    Tasuku Mariya, Toyotaka Sato, Yuya Fujibe, Manami Ishido, Hiroshi Shimada, Terufumi Kubo, Yoko Nagai, Wataru Arai, Suguru E Tanaka, Kyota Ashikawa, Yoshiyuki Sakuraba, Shinichi Ishioka, Shin-Ichi Yokota, Tsuyoshi Saito

    Medical molecular morphology   54 ( 4 )   374 - 379   2021.12

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    Intrauterine infection is one of the most important causes of maternal death. In perinatal emergency, we often miss an opportunity to obtain culture specimens. In this study, we tried to examine whether we investigated whether bacteria causing infection can be detected from a formalin-fixed paraffin-embedded (FFPE) placental specimen. We examined the placenta from a maternal invasive infection that resulted in infectious abortion at 18 weeks of gestation. The case was diagnosed by acute fever and abdominal pain, and the patient was cured after 3 weeks of intensive antimicrobial treatment. Four Streptococcus pyogenes strains were isolated from vaginal fluid and blood cultures of the patient. All of the strain types were emm1/ST28. We amplified the V1-V2 region of 16S rRNA from an FFPE placental specimen and sequencing was performed using a next-generation sequencer (NGS). Taxonomic analysis was then performed for sequenced data. We succeeded in detecting causative pathogens from the FFPE placenta: 69.1% of the predominantly identified bacteria were S. pyogenes and other small populations of bacteria were detected. Our results revealed the utility of NGS for 16S rRNA analysis of an FFPE placenta. This method may reveal previous perinatal invasive infections of unknown origin retrospectively.

    DOI： 10.1007/s00795-021-00298-2

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  • Possibility of Targeting Claudin-2 in Therapy for Human Endometrioid Endometrial Carcinoma

    Tadahi Okada, Takumi Konno, Takayuki Kohno, Hiroshi Shimada, Kimihito Saito, Seiro Satohisa, Tsuyoshi Saito, Takashi Kojima

    Reproductive Sciences   2020.6

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s43032-020-00230-6

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  • ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer

    Takumi Konno, Takayuki Kohno, Tadahi Okada, Hiroshi Shimada, Seiro Satohisa, Shin Kikuchi, Tsuyoshi Saito, Takashi Kojima

    Histochemistry and Cell Biology   2020.4

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00418-020-01876-8

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  • Epithelial barrier dysfunction and cell migration induction via JNK/cofilin/actin by angubindin-1. Reviewed International journal

    Takumi Konno, Takayuki Kohno, Shin Kikuchi, Hiroshi Shimada, Seiro Satohisa, Tsuyoshi Saito, Masuo Kondoh, Takashi Kojima

    Tissue barriers   8 ( 1 )   1695475 - 1695475   2020.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    Angulin-1/LSR is a tricellular tight junction molecule, that plays an important role in maintaining the epithelial and endothelial barriers. The actin cytoskeleton at tricellular contacts also contributes to the maintenance of the epithelial barrier. Loss of angulin-1/LSR enhances the migration of various cancer cells. Angubindin-1 is a novel binder to angulin-1/LSR and angulin-3. It is a peptide generated from the angulin-1 binding site of Clostridium perfringens iota toxin, which affects the actin cytoskeleton and decreases the epithelial and endothelial barrier functions. However, its regulatory mechanisms are not well understood. To investigate the regulatory mechanisms of the epithelial barrier dysfunction and cell migration induction by angubindin-1, we used human endometrial cancer cell line Sawano, which has high LSR expression and the epithelial barrier function. Angubindin-1 decreased LSR expression and the epithelial barrier function and increased cell migration. It inhibited the recovery of the epithelial barrier function in a Ca-switch model. At tricellular contacts, sinking of the membrane and an increase of actin fibers near the junctions were caused by angubindin-1. It dynamically changed F-actin from lines to dot-like structures at tricellular contacts. Angubindin-1 transiently increased the phosphorylation of cofilin and JNK, which are involved in the regulation of the intracellular actin cytoskeleton. Furthermore, knockdown of JNK and the JNK inhibitor SP600125 prevented the decrease of the epithelial barrier function and the increase of cell migration induced by angubindin-1. These findings suggest that angubindin-1 might reversibly regulate the epithelial barrier and cell migration at tricellular contacts via JNK/cofilin/actin cytoskeleton dynamics.

    DOI： 10.1080/21688370.2019.1695475

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  • Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells

    Takumi Konno, Takayuki Kohno, Shin Kikuchi, Hiroshi Shimada, Seiro Satohisa, Kenichi Takano, Tsuyoshi Saito, Takashi Kojima

    Journal of Histochemistry & Cytochemistry   68 ( 1 )   59 - 72   2019.10

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    Publishing type：Research paper (scientific journal)   Publisher：{SAGE} Publications  

    DOI： 10.1369/0022155419886263

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  • The role of claudin-2 on the malignancy of human endometrioid carcinoma tissues Reviewed

    Satohisa Seiro, Shimada Hiroshi, Kohno Takayuki, Konno Takumi, Tamate Masato, Matsuura Motoki, Teramoto Mizue, Akimoto Taishi, Iwasaki Masahiro, Kojima Takashi, Saito Tsuyoshi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   28   109   2018.10

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  • Downregulation of lipolysis‑stimulated lipoprotein receptor promotes cell invasion via claudin‑1‑mediated matrix metalloproteinases in human endometrial cancer

    Hiroshi Shimada, Seiro Satohisa, Takayuki Kohno, Takumi Konno, Ken‑Ichi Takano, Syunta Takahashi, Tsubasa Hatakeyama, Chihiro Arimoto, Tsuyoshi Saito, Takashi Kojima

    Oncology Letters   2017.9

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    Publishing type：Research paper (scientific journal)   Publisher：Spandidos Publications  

    DOI： 10.3892/ol.2017.7038

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  • Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer

    Hiroshi Shimada, Shyuetsu Abe, Takayuki Kohno, Seiro Satohisa, Takumi Konno, Syunta Takahashi, Tsubasa Hatakeyama, Chihiro Arimoto, Takuya Kakuki, Yakuto Kaneko, Ken-ichi Takano, Tsuyoshi Saito, Takashi Kojima

    Scientific Reports   2017.1

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep37049

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  • Downregulation of LSR promotes cell invasion via claudin-1-mediated MMPs in human endometrial cancer. Reviewed

    Shimada H, Satohisa S, Kohno T, Konno T, Takano K, Takahashi S, Hatakeyama T, Arimoto C, Saito T, Kojima T

    Oncology Letters   14(6):6776-6782.   2017

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  • The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells

    Hiroshi Shimada, Seiro Satohisa, Takayuki Kohno, Syunta Takahashi, Tsubasa Hatakeyama, Takumi Konno, Mitsuhiro Tsujiwaki, Tsuyoshi Saito, Takashi Kojima

    Oncotarget   7 ( 19 )   27735 - 27752   2016.3

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    Publishing type：Research paper (scientific journal)   Publisher：Impact Journals, {LLC}  

    DOI： 10.18632/oncotarget.8408

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  • Trophoblast-specific overexpression of Adiponectin Receptor 2 inhibits placental mitochondrial respiration in mice.

    Hiroshi Shimada, Barentsen K, Erickson K, Urschitz J, Powell TL, Jansson T, Rosario FJ

    2024.9

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  • 前置血管の1例

    杉山 芽, 嶋田 浩志, 西森 貢隆, 藤部 佑哉, 鈴木 美紀, 石岡 伸一, 齋藤 豪

    北海道産科婦人科学会会誌   67 ( 1 )   79 - 79   2023.12

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  • 婦人科内視鏡技術認定医が不在である当院でのTLHの取り組み

    西森 貢隆, 嶋田 浩志, 藤部 佑哉, 鈴木 美紀, 玉手 雅人, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

    北海道産科婦人科学会会誌   67 ( 1 )   91 - 91   2023.12

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  • 子宮原発骨肉腫の1例

    南 香穂, 嶋田 浩志, 今 沙織, 鈴木 美紀, 玉手 雅人, 幅田 周太朗, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   70回   65 - 65   2023.9

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    Language：Japanese   Publisher：東北連合産科婦人科学会・北日本産科婦人科学会  

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  • ヒト子宮内膜症のin vitroモデルを用いた新規病態メカニズムの解明

    長尾来夢, 長尾来夢, 幸野貴之, 金野匠, 倉ありさ, 倉ありさ, 斉藤公仁, 嶋田浩志, 齋藤豪, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   55th   2023

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  • 帝王切開創のケロイド予防とその修復の取り組み

    杉山 芽, 嶋田 浩志, 玉手 雅人, 仁木 舜一, 今 沙織, 鈴木 美紀, 石岡 伸一, 斎藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   69回   66 - 66   2022.10

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  • 巨大嚢胞化し、子宮留膿腫を繰り返した帝王切開瘢痕部症候群の1例

    仁木 舜一, 嶋田 浩志, 玉手 雅人, 杉山 芽, 今 沙織, 鈴木 美紀, 松浦 基樹, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   69回   112 - 112   2022.10

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  • 卵巣悪性腫瘍の術前に偶発的に指摘された膵内副脾の1症例

    宿田 耕之介, 横山 和典, 小山 一也, 椎名 脩, 代田 充, 高橋 秀徳, 嶋田 浩志, 山城 勝重

    日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集   130回・124回   77 - 77   2022.3

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    Language：Japanese   Publisher：日本消化器病学会-北海道支部  

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  • 巨大絨毛膜下嚢胞の1例

    嶋田浩志, 嶋田浩志, 杉山芽, 今沙織, 石岡伸一, 齋藤豪

    日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集   40th-30th (CD-ROM)   2022

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  • 子宮内膜症,子宮内膜癌細胞におけるAngulin-1/Lipolysis Stimulated Lipoprotein Receptor(LSR)の役割

    斉藤公仁, 斉藤公仁, 嶋田浩志, 金野匠, 倉ありさ, 倉ありさ, 岡田匡氷, 郷久晴朗, 幸野貴之, 松浦基樹, 齋藤豪, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   54th   2022

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  • 子宮内膜癌におけるタイト結合分子cingulin(CGN)の役割

    倉ありさ, 倉ありさ, 斉藤公仁, 斉藤公仁, 岡田匡氷, 嶋田浩志, 金野匠, 幸野貴之, 松浦基樹, 齋藤豪, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   54th   2022

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  • 最終摘出から16年後に再発した卵巣癌ポート部位転移の1例

    杉山 芽, 嶋田 浩志, 西森 貢隆, 藤部 佑哉, 鈴木 美紀, 玉手 雅人, 松浦 基樹, 岩崎 雅宏, 斎藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   68回   65 - 65   2021.8

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  • Bevacizumab併用PTX療法が奏功したBevacizumab併用化学療法既往のある再発子宮頸部腺癌の1例

    西森 貢隆, 嶋田 浩志, 杉山 芽, 藤部 佑哉, 鈴木 美紀, 玉手 雅人, 松浦 基樹, 岩崎 雅宏, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   68回   59 - 59   2021.8

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  • 帝王切開瘢痕症候群に対して腹腔鏡下修復術および子宮鏡下内膜ポリープ切除術を行った1例

    倉 ありさ, 藤部 佑哉, 石堂 茉泉, 鈴木 美紀, 玉手 雅人, 嶋田 浩志, 齋藤 豪

    産婦人科手術   ( 32 )   146 - 146   2021.6

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    Language：Japanese   Publisher：(株)メジカルビュー社  

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  • 妊娠糖尿病患者における妊娠中の適切な体重増加の検討

    藤部 佑哉, 嶋田 浩志, 真里谷 奨, 倉 ありさ, 西森 貢隆, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   57 ( Suppl. )   P221 - P221   2021.6

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  • 妊娠時に繰り返す脱落膜ポリープを保存的に管理し第1子で死産となるも第2子で生児を得た1例

    倉 ありさ, 藤部 佑哉, 石堂 茉泉, 鹿内 智史, 野藤 五沙, 新開 翔太, 嶋田 浩志, 鈴木 美紀, 石岡 伸一, 齋藤 豪

    北海道産科婦人科学会会誌   65 ( 1 )   32 - 37   2021.3

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  • タイト結合分子Cluadin-2をターゲットにした子宮内膜癌治療のin vitroにおける検討

    嶋田 浩志, 岡田 匡氷, 金野 匠, 幸野 貴之, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 小島 隆, 齋藤 豪

    日本婦人科腫瘍学会雑誌   39 ( 1 )   285 - 285   2021.1

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  • Possibility of tricelluler tight junction LSR/Angulin-1 antibody in therapy for human endometrioid endometrial carcinoma

    斉藤公仁, 幸野貴之, 金野匠, 岡田匡氷, 嶋田浩志, 郷久晴朗, 近藤昌夫, 齋藤豪, 小島隆

    日本分子生物学会年会プログラム・要旨集(Web)   44th   2021

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  • 妊娠糖尿病患者における妊娠中の適切な体重増加の検討

    藤部佑哉, 嶋田浩志, 真里谷奨, 倉ありさ, 西森貢隆, 石岡伸一, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   57 ( Suppl )   2021

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  • 開腹子宮頸部縫縮術(TAC)後妊娠初期流産症例に対するmethotrexate(MTX)療法の一例

    石堂 茉泉, 石岡 伸一, 藤部 佑哉, 鈴木 美紀, 嶋田 浩志, 真里谷 奨, 馬場 剛, 齋藤 豪

    日本周産期・新生児医学会雑誌   56 ( 1 )   198 - 202   2020.5

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    Language：Japanese   Publisher：(一社)日本周産期・新生児医学会  

    34歳。子宮頸癌のため腟式広汎子宮頸部摘出術+骨盤リンパ節郭清術の既往で有った。その2年後に体外受精により妊娠し、妊娠19週で帝王切開による分娩となった。この分娩から3年後にテフロンテープを用いた開腹子宮頸部縫縮術(TAC)を施行し、TAC後6ヵ月で体外受精にて妊娠したが、妊娠8週で稽留流産となった。流産後3ヵ月経過しても子宮内容物が排出されず絨毛組織の筋層内浸潤が疑われ、流産後12週よりMTX投与1日20mg・5日間を2週間毎に開始し、3コース終了後に血清ヒト絨毛性ゴナドトロピン値がほぼ正常化した。治療終了後3ヵ月で月経が再開し、その後に再度妊娠8週相当で流産となったが、子宮内容物は流産判明から1ヵ月以内に自然排出された。さらに6ヵ月後に体外受精で妊娠し、妊娠33週6日に帝王切開にて男児1912g、アプガースコア8/9点を出産し、術後経過順調で8日目に退院した。

    Other Link:： https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J04116&link_issn=&doc_id=20200817330032&doc_link_id=%2Fdy1jspnm%2F2020%2F005601%2F032%2F0198-0202%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdy1jspnm%2F2020%2F005601%2F032%2F0198-0202%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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  • 当科で分娩後に絨毛膜外性胎盤と診断された2例

    山下 真祐子, 高田 さくら, 水柿 祐子, 山崎 智子, 嶋田 浩志, 恐神 博行, 齋藤 豪

    北海道産科婦人科学会会誌   64 ( 1 )   113 - 113   2020.3

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  • 家族性に発生した処女膜閉鎖症例

    梅本 美菜, 鈴木 将裕, 鹿内 智史, 伊野 善彦, 杉田 菜穂子, 嶋田 浩志, 真里谷 奨, 遠藤 俊明, 齋藤 豪

    北海道産科婦人科学会会誌   64 ( 1 )   100 - 101   2020.3

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  • Administration of methotrexate (MTX) for a patient with missed abortion after transabdominal cerclage (TAC)

    石堂茉泉, 石岡伸一, 藤部佑哉, 鈴木美紀, 嶋田浩志, 真里谷奨, 馬場剛, 齋藤豪

    日本周産期・新生児医学会雑誌(Web)   56 ( 1 )   2020

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  • 子宮内膜症のin vitroモデルを用いた病態メカニズムの解明

    嶋田浩志, 岡田匡氷, 金野匠, 郷久晴朗, 幸野貴之, 小島隆, 齋藤豪

    日本エンドメトリオーシス学会プログラム・抄録集   41st   2020

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  • 繰り返す脱落膜ポリープの管理に苦慮するも生児を得た1例

    倉 ありさ, 藤部 佑哉, 石堂 茉泉, 鹿内 智史, 野藤 五沙, 嶋田 浩志, 石岡 伸一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   67回   51 - 51   2019.9

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  • タイト結合による子宮内膜の悪性化制御機序

    郷久 晴朗, 嶋田 浩志, 岩崎 雅宏, 染谷 真行, 金野 匠, 菊池 真, 幸野 貴之, 玉手 雅人, 松浦 基樹, 小島 隆, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   67回   36 - 36   2019.9

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  • 発症後早期の抗生剤治療が救命につながった激症分娩型A群連鎖球菌感染症

    石堂 茉泉, 嶋田 浩志, 倉 ありさ, 藤部 佑哉, 鈴木 美紀, 長尾 沙智子, 新開 翔太, 真里谷 奨, 染谷 真行, 森下 美幸, 馬場 剛, 石岡 伸一, 横田 伸一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   67回   61 - 61   2019.9

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  • 子宮内膜悪性化におけるタイト結合分子claudin-2の関与

    郷久 晴朗, 嶋田 浩志, 岩崎 雅宏, 秋元 太志, 西村 庸子, 玉手 雅人, 寺田 倫子, 松浦 基樹, 金野 匠, 幸野 貴之, 小島 隆, 齋藤 豪

    日本婦人科腫瘍学会雑誌   37 ( 3 )   497 - 497   2019.6

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  • リステリア菌血症により流産に至った1例

    藤部 佑哉, 真里谷 奨, 嶋田 浩志, 山中 郁仁, 水内 将人, 寺本 瑞絵, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   55 ( 2 )   530 - 530   2019.6

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  • 子宮内膜癌細胞におけるタイト結合分子claudin-2の関与

    郷久 晴朗, 嶋田 浩志, 玉手 雅人, 秋元 太志, 西村 庸子, 寺田 倫子, 松浦 基樹, 岩崎 雅宏, 小島 隆, 齋藤 豪

    日本臨床細胞学会雑誌   58 ( Suppl.1 )   320 - 320   2019.5

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  • 自然消失した子宮動脈仮性動脈瘤の超音波パワードップラー法所見の変化

    嶋田 浩志, 野藤 五沙, 鈴木 美紀, 幅田 周太朗, 藤部 佑哉, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    超音波医学   46 ( Suppl. )   S719 - S719   2019.4

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  • 異なる転機をたどったchorionic bumpの2例

    藤部 佑哉, 水内 将人, 嶋田 浩志, 真里谷 奨, 野呂 薫, 山中 郁仁, 寺本 瑞絵, 馬場 剛, 石岡 伸一, 齋藤 豪

    超音波医学   46 ( Suppl. )   S726 - S726   2019.4

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  • 子宮内膜癌の悪性化におけるASPP2の役割

    嶋田 浩志, 郷久 晴朗, 野藤 五沙, 幅田 周太朗, 松浦 基樹, 寺本 瑞絵, 岩崎 雅宏, 齋藤 豪

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 504   2019.2

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  • 同胞の治療が契機となり判明した姉妹発症の処女膜閉鎖症

    鈴木 将裕, 真里谷 奨, 梅本 美菜, 鹿内 智史, 杉田 奈穂子, 嶋田 浩志, 玉手 雅人, 遠藤 俊明, 斎藤 豪

    産科と婦人科   86 ( 2 )   271 - 275   2019.2

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  • 子宮内膜癌細胞におけるタイト結合分子claudin-2の関与

    郷久晴朗, 嶋田浩志, 玉手雅人, 秋元太志, 西村庸子, 寺田倫子, 松浦基樹, 岩崎雅宏, 小島隆, 齋藤豪

    日本臨床細胞学会雑誌(Web)   58   2019

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  • Angubindin-1による癌細胞の集団運動能の亢進

    幸野貴之, 金野匠, 近藤昌夫, 嶋田浩志, 齋藤豪, 小島隆

    日本分子生物学会年会プログラム・要旨集(Web)   42nd   2019

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  • ASPP2欠損はLSRおよびYAPを介して子宮内膜癌の悪性化を誘導する

    金野匠, 幸野貴之, 嶋田浩志, 郷久晴朗, 菊池真, 齋藤豪, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   51st   2019

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  • 子宮内膜癌(endometrioid)の悪性化におけるタイト結合分子claudin-2の役割

    岡田匡氷, 岡田匡氷, 金野匠, 嶋田浩志, 郷久晴朗, 幸野貴之, 齋藤豪, 小島隆

    日本分子生物学会年会プログラム・要旨集(Web)   42nd   2019

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  • ASPP2欠損はLSRおよびYAPを介して子宮内膜癌の悪性化を誘導する

    金野匠, 幸野貴之, 嶋田浩志, 郷久晴朗, 菊池真, 齋藤豪, 小島隆

    日本細胞生物学会大会(Web)   71st   2019

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  • 胎児期の急激な肝腫大で発見された一過性骨髄異常増殖症の1例

    山下 真祐子, 高田 さくら, 山崎 智子, 嶋田 浩志, 恐神 博行, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   66回   0127 - 0127   2018.9

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  • 術後卵巣癌として治療中に大腸癌と判明した1症例

    幅田 周太朗, 野藤 五沙, 嶋田 浩志, 横山 和典, 松浦 基樹, 郷久 晴朗, 寺本 瑞絵, 岩崎 雅宏, 斎藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   66回   0067 - 0067   2018.9

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  • Loss of ASPP2 promote cell invasion and migration via YAP in human endometrial cancer

    Hiroshi Shimada, Seiro Satohisa, Takumi Konno, Motoki Matsuura, Mizue Teramoto, Masahiro Iwasaki, Takayuki Kohno, Takashi Kojima, Tsuyoshi Saito

    2018.9

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  • 重症子宮内膜症で安全に直腸の癒着を剥離するために、逆行性子宮全摘が有効と考えられた症例

    恐神 博行, 山下 真祐子, 嶋田 浩志

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   329 - 329   2018.8

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  • A retrospective examination of antenatal treatment for Streptococcus agalactiae infection at the birth canal using oral antibiotics

    真里谷奨, 鹿内智史, 嶋田浩志, 杉田奈穗子, 鈴木将裕, 野手健司, 鷲見亮太, 齋藤豪

    帯広協会病院医誌   3 ( 3 )   17 - 27   2018.7

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  • 2009年IOM指針に基づいた推奨妊娠中体重増加における出生児体重の検討

    嶋田 浩志, 高田 さくら, 恐神 博行, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   54 ( 2 )   717 - 717   2018.6

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  • 慎重な管理により正期産児を得た胎児腹腔内臍静脈瘤の2例

    高田 さくら, 水内 将人, 嶋田 浩志, 恐神 博行, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   54 ( 2 )   694 - 694   2018.6

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  • 多機能な細胞接着分子が関わるがんの理解 診断・治療への応用をめざして 3細胞間タイト結合分子LSRの発現低下によるがん細胞の悪性化機序

    金野 匠, 嶋田 浩志, 郷久 晴朗, 齋藤 豪, 幸野 貴之, 小島 隆

    日本病理学会会誌   107 ( 1 )   242 - 242   2018.4

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  • 子宮頸部細胞診ASC-US症例における従来法と液状検体法による比較検討

    鹿内 智史, 真里谷 奨, 嶋田 浩志, 玉手 雅人, 黒田 敬史, 齋藤 豪

    北海道産科婦人科学会会誌   62 ( 1 )   172 - 172   2018.3

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  • 卵巣腫瘍および腸管型GISTとの鑑別に苦慮した非医原性腸管parasitic leiomyoma

    鈴木 麻由, 嶋田 浩志, 阿部 秀悦, 鹿内 智史, 真里谷 奨, 橋本 卓, 阿部 厚憲, 齋藤 豪

    北海道産科婦人科学会会誌   62 ( 1 )   193 - 193   2018.3

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  • 非医原性parasitic leiomyomaの一例

    嶋田 浩志, 阿部 秀悦, 鹿内 智史, 真里谷 奨, 橋本 卓, 阿部 厚憲, 郷久 晴朗, 齋藤 豪

    北海道産科婦人科学会会誌   62 ( 1 )   21 - 24   2018.3

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  • 3細胞間タイト結合分子Angulin-1/LSRリガンドAngubindin-1による上皮バリア調節機構

    金野匠, 幸野貴之, 菊地真, 嶋田浩志, 郷久晴朗, 齋藤豪, 近藤昌夫, 小島隆

    日本分子生物学会年会プログラム・要旨集(Web)   41st   2018

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  • 3細胞間タイト結合分子Angulin-1/LSRリガンドAngubindin-1によるアクチン骨格を介した上皮バリア調節機構

    金野匠, 幸野貴之, 菊池真, 嶋田浩志, 郷久晴朗, 齋藤豪, 近藤昌夫, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   50th   2018

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  • 3細胞間タイト結合分子LSRリガンドAngubindin-1によるJNK/cofilin/actinを介した上皮バリア調節機構

    金野匠, 幸野貴之, 菊池真, 嶋田浩志, 郷久晴朗, 齋藤豪, 近藤昌夫, 小島隆

    臨床ストレス応答学会大会抄録集   13th   2018

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  • 細胞質分裂における3細胞間タイト結合分子の局在と役割

    金野 匠, 幸野 貴之, 菊池 真, 嶋田 浩志, 郷久 晴朗, 齋藤 豪, 小島 隆

    生命科学系学会合同年次大会   2017年度   [2P - 0351]   2017.12

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  • 急性虫垂炎との鑑別に難渋し診断的腹腔鏡にて卵管留血腫の茎捻転と判明した女児の1例

    鹿内 智史, 真里谷 奨, 嶋田 浩志, 郷久 晴朗, 高橋 徹, 齋藤 豪

    産科と婦人科   84 ( 12 )   1513 - 1517   2017.12

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  • 腰背部皮下組織に発生した転移性平滑筋腫の1例

    水柿 祐子, 嶋田 浩志, 高田 さくら, 恐神 博行

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   65回   99 - 99   2017.9

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  • 腹腔鏡下子宮全摘術時のリスク低減卵管切除に関する検討

    真里谷 奨, 鹿内 智史, 嶋田 浩志, 杉田 奈穂子, 鈴木 将裕, 三浦 一郎, 三浦 千砂子, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   1219 - 1219   2017.8

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  • TLHにおいて安全かつスムーズに子宮を摘出するための後腹膜腔展開

    恐神 博行, 嶋田 浩志, 水柿 祐子

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   746 - 746   2017.8

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  • 3細胞間タイト結合分子LSRはAMOTに活性化されたHippo pathwayを介し子宮内膜癌の悪性化に関与する

    郷久 晴朗, 嶋田 浩志, 阿部 秀悦, 玉手 雅人, 寺田 倫子, 鈴木 美和, 寺本 瑞絵, 秋元 太志, 野藤 五沙, 小川 万梨絵, 田中 綾一, 松浦 基樹, 岩崎 雅宏, 小島 隆, 齋藤 豪

    日本婦人科腫瘍学会雑誌   35 ( 3 )   527 - 527   2017.6

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  • 異なる転帰をたどった周郭胎盤の2例

    嶋田 浩志, 真里谷 奨, 高田 さくら, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    日本周産期・新生児医学会雑誌   53 ( 2 )   693 - 693   2017.6

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  • 当院における死戦期帝王切開を念頭においた産科救急システムの構築

    水内 将人, 藤部 佑哉, 嶋田 浩志, 馬場 剛, 石岡 伸一, 斎藤 豪

    日本周産期・新生児医学会雑誌   53 ( 2 )   727 - 727   2017.6

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  • 3細胞間タイト結合蛋白LSRはYAP/AMOT/merlinを介して子宮内膜癌の悪性化へ関与する

    阿部 秀悦, 嶋田 浩志, 郷久 晴朗, 金野 匠, 齋藤 豪, 幸野 貴之, 小島 隆

    日本細胞生物学会大会講演要旨集   69回   95 - 95   2017.5

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  • がん細胞の上皮バリアおよび悪性化における糖代謝の役割

    金野 匠, 幸野 貴之, 及能 大輔, 嶋田 浩志, 郷久 晴朗, 角木 拓也, 金子 躍人, 高野 賢一, 齋藤 豪, 小島 隆

    日本細胞生物学会大会講演要旨集   69回   95 - 95   2017.5

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  • 不妊症精査を契機に診断された子宮結核および結核性ぶどう膜炎の一例

    真里谷 奨, 阿部 秀悦, 鹿内 智史, 嶋田 浩志, 白枝 友子, 田邊 章浩, 本間 寛之, 齋藤 豪

    日本産婦人科感染症学会学術講演会プログラム・抄録集   34回   51 - 51   2017.5

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  • 子宮内膜細胞の悪性化におけるASPP2の役割

    郷久 晴朗, 嶋田 浩志, 岩崎 雅宏, 寺田 倫子, 鈴木 美和, 秋元 太志, 寺本 瑞絵, 田中 綾一, 阿部 秀祝, 齋藤 豪

    日本臨床細胞学会雑誌   56 ( Suppl.1 )   353 - 353   2017.4

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  • 超音波検査により内膜症性嚢胞と誤認していたOHVIRA症候群に伴う腟留血腫の1例

    嶋田 浩志, 鹿内 智史, 真里谷 奨, 水内 将人, 馬場 剛, 石岡 伸一, 齋藤 豪

    超音波医学   44 ( Suppl. )   S680 - S680   2017.4

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  • 全妊婦を対象とした前置血管の出生前スクリーニング体制の構築

    水内 将人, 嶋田 浩志, 高田 さくら, 石岡 伸一, 齋藤 豪

    超音波医学   44 ( Suppl. )   S560 - S560   2017.4

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  • 細胞密度に依存的なLSRの膜での局在変化はミオシン活性と相関する

    幸野 貴之, 嶋田 浩志, 金野 匠, 小島 隆

    日本病理学会会誌   106 ( 1 )   356 - 356   2017.3

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  • 経口抗生剤を用いた予防的産道Group B Streptococcus除菌の試みと腟内細菌叢との関連について

    真里谷 奨, 中田 富子, 鹿内 智史, 嶋田 浩志, 齋藤 豪

    日本化学療法学会雑誌   65 ( Suppl.A )   262 - 262   2017.3

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  • 子宮内膜癌(endometrioid adenocarcinoma)におけるタイト結合分子claudin-2の役割

    嶋田浩志, 金野匠, 郷久晴朗, 阿部秀悦, 幸野貴之, 齋藤豪, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   49th   2017

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  • 細胞分裂における3細胞間タイト結合分子の局在変化と役割

    金野匠, 幸野貴之, 菊池真, 嶋田浩志, 郷久晴朗, 齋藤豪, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   49th   2017

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  • 子宮内膜細胞の悪性化におけるASPP2の役割

    郷久晴朗, 嶋田浩志, 岩崎雅宏, 寺田倫子, 鈴木美和, 秋元太志, 寺本瑞絵, 田中綾一, 阿部秀悦, 齋藤豪

    日本臨床細胞学会雑誌(Web)   56   2017

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  • 卵巣腫瘍および腸管型GISTとの鑑別に苦慮した非医原性腸管parasitic leiomyoma

    鈴木 麻由, 嶋田 浩志, 阿部 秀悦, 鹿内 智史, 真里谷 奨, 橋本 卓, 阿部 厚憲, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   64回   116 - 116   2016.9

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  • 子宮頸部細胞診ASC-US症例における従来法と液状検体法による比較検討

    鹿内 智史, 真里谷 奨, 嶋田 浩志, 玉手 雅人, 黒田 敬史, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   64回   89 - 89   2016.9

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  • 腹腔鏡下に診断し得た女児の左卵管留血腫

    鹿内 智史, 嶋田 浩志, 真里谷 奨, 郷久 晴朗, 高橋 徹, 齋藤 豪

    日本産科婦人科内視鏡学会雑誌   32 ( Suppl.I )   246 - 246   2016.8

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  • 3細胞間タイト結合蛋白LSRはHippo pathwayを介して子宮内膜癌の悪性化に関与している

    嶋田 浩志, 郷久 晴朗, 金野 匠, 高橋 駿太, 畠山 翔翼, 幸野 貴之, 田中 綾一, 寺本 瑞絵, 岩崎 雅宏, 小島 隆, 齋藤 豪

    日本婦人科腫瘍学会雑誌   34 ( 3 )   416 - 416   2016.6

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  • BMI66.5kg/m2の高度肥満妊婦における帝王切開の経験

    森下 美幸, 嶋田 浩志, 馬場 剛, 石岡 伸一, 遠藤 俊明, 齋藤 豪

    産科と婦人科   83 ( 2 )   226 - 231   2016.2

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  • 肥満による子宮内膜癌の悪性化におけるLSR(lipolysis-stimulated lipoprotein receptor)の役割

    嶋田 浩志, 郷久 晴朗, 寺本 瑞絵, 田中 綾一, 岩崎 雅宏, 小島 隆, 齋藤 豪

    日本産科婦人科学会雑誌   68 ( 2 )   631 - 631   2016.2

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  • 再発を来した悪性卵巣胚細胞腫瘍の検討

    嶋田 浩志, 田中 綾一, 鈴木 美和, 高橋 円, 郷久 晴朗, 寺本 瑞絵, 岩崎 雅宏, 齋藤 豪

    日本婦人科腫瘍学会雑誌   34 ( 1 )   26 - 36   2016.1

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  • LSR/YAP/AMOT/merlinによる子宮内膜癌の悪性化への関与

    嶋田浩志, 郷久晴朗, 金野匠, 有元千紘, 高橋駿太, 畠山翔翼, 幸野貴之, 齋藤豪, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   48th   2016

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  • 子宮内膜腺癌細胞株Sawanoにおける3細胞間タイト結合タンパク質LSRの局在を規定する細胞形態変化

    幸野貴之, 菊池真, 二宮孝文, 嶋田浩志, 金子躍人, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   48th   2016

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  • 肥満によるヒト子宮内膜癌の悪性化におけるlipolysis-stimulated lipoprotein receptorの役割

    小島 隆, 嶋田 浩志, 郷久 晴朗, 金野 匠, 高橋 俊太, 畠山 翔翼, 有元 千尋, 野島 伊世里, 齋藤 豪, 幸野 貴之

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回   [3T18p - 01(3P1048)]   2015.12

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  • 卵巣原発膠芽腫に対し手術・化学放射線療法を施行後、再々発しCBDCA/VP-16療法が奏効した一例

    伊坂 五沙, 郷久 晴朗, 岩崎 雅宏, 竹浪 奈穂子, 嶋田 浩志, 寺本 瑞絵, 田中 綾一, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   63回   93 - 93   2015.9

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  • 手術・化学放射線療法を施行後再々発し、CBDCA/VP-16療法が奏効した卵巣原発膠芽腫の一例

    郷久 晴朗, 岩崎 雅宏, 竹浪 奈穂子, 阿部 秀悦, 嶋田 浩志, 玉手 雅人, 幅田 周太朗, 鈴木 美和, 寺本 瑞絵, 田中 綾一, 斎藤 豪

    日本婦人科腫瘍学会雑誌   33 ( 3 )   609 - 609   2015.6

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  • ヒト子宮内膜癌細胞の悪性化におけるlipolysis-stimulated lipoprotein receptorの役割

    嶋田 浩志, 郷久 晴朗, 金野 匠, 高橋 俊太, 畠山 翔翼, 齋藤 豪, 幸野 貴之, 小島 隆

    日本細胞生物学会大会講演要旨集   67回   167 - 167   2015.6

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  • LSRの細胞膜局在に対する細胞間相互作用の影響

    幸野 貴之, 金子 躍人, 角木 拓也, 嶋田 浩志, 小島 隆

    日本細胞生物学会大会講演要旨集   67回   196 - 196   2015.6

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  • 子宮体がん基礎 肥満による子宮内膜癌の悪性化におけるLSR(lipolysis-stimulated lipoprotein receptor)の役割

    嶋田 浩志, 小島 隆, 郷久 晴朗, 金野 匠, 高橋 俊太, 畠山 翔翼, 幸野 貴之, 寺本 瑞絵, 田中 綾一, 岩崎 雅宏, 斎藤 豪

    日本婦人科腫瘍学会雑誌   33 ( 3 )   535 - 535   2015.6

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  • 胎児診断したisolated TAPVRの一例

    浅野 拓也, 嶋田 浩志, 寺田 倫子, 齋藤 雅恵, 岡村 直樹, 横澤 正人, 遠藤 俊明, 齋藤 豪

    北海道産科婦人科学会会誌   59 ( 1 )   198 - 198   2015.3

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  • 当院で経験した18トリソミー症候群の胎児超音波所見の検討

    嶋田 浩志, 浅野 拓也, 沼田 佳苗, 染谷 真行, 竹田 倫子, 岡村 直樹, 遠藤 俊明, 齋藤 豪

    北海道産科婦人科学会会誌   59 ( 1 )   201 - 201   2015.3

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  • 治療方針に苦慮した急性Stanford A型大動脈解離合併妊娠

    嶋田 浩志, 遠藤 俊明, 山本 雅恵, 杉尾 明香, 清水 亜由美, 森下 美幸, 明石 祐史, 馬場 剛, 石岡 伸一, 齋藤 豪

    北海道産科婦人科学会会誌   59 ( 1 )   22 - 26   2015.3

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  • Lipolysis-stimulated lipoprotein receptor(LSR)はタイト結合分子claudin-1を制御し子宮内膜癌細胞浸潤に関与する

    郷久 晴朗, 小島 隆, 嶋田 浩志, 竹浪 奈穂子, 玉手 雅人, 西澤 庸子, 秋元 太志, 寺本 瑞絵, 田中 綾一, 岩崎 雅宏, 齋藤 豪

    日本産科婦人科学会雑誌   67 ( 2 )   547 - 547   2015.2

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  • 子宮内膜癌の悪性化における新規3細胞間タイト結合分子LSRの関与

    嶋田浩志, 郷久晴朗, 金野匠, 有元千紘, 高橋駿太, 畠山翔翼, 幸野貴之, 齋藤豪, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   47th   2015

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  • 肥満による子宮内膜癌の悪性化におけるLSR(lipolysis-stimulated lipoprotein receptor)の役割

    嶋田浩志, 小島隆, 郷久晴朗, 金野匠, 高橋俊太, 畠山翔翼, 幸野貴之, 寺本瑞絵, 田中綾一, 岩崎雅宏, 斎藤豪

    日本婦人科腫瘍学会雑誌   33 ( 3 )   2015

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  • 膵癌における3細胞間タイト結合分子LSRの役割

    有元千絋, 河野剛, 嶋田浩志, 金野匠, 畠山翔翼, 高橋駿太, 及能大輔, 幸野貴之, 小島隆

    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集   47th   2015

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  • 当院における予防的・治療的頸管縫縮術の後方視的検討

    沼田 佳苗, 染谷 真行, 嶋田 浩志, 竹田 倫子, 岡村 直樹

    日本周産期・新生児医学会雑誌   50 ( 2 )   839 - 839   2014.6

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  • 双胎妊娠中に診断された異所性PTH産生腫瘍による高カルシウム血症の一例

    染谷 真行, 嶋田 浩志, 沼田 佳苗, 竹田 倫子, 岡村 直樹

    日本周産期・新生児医学会雑誌   50 ( 2 )   721 - 721   2014.6

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  • 予後不良であった卵巣悪性胚細胞腫瘍2例の検討

    新開 翔太, 田中 綾一, 山中 郁仁, 嶋田 浩志, 鈴木 美和, 高橋 円, 長澤 邦彦, 伊東 英樹, 齋藤 豪

    北海道産科婦人科学会会誌   58 ( 1 )   112 - 113   2014.3

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  • A case of malignant giant ovarian tumor weighing 26 kg

    嶋田浩志, 沼田佳苗, 齋藤雅恵, 浅野拓也, 染谷真行, 竹田倫子, 岡村直樹

    市立釧路総合病院医学雑誌   26 ( 1 )   13 - 17   2014.3

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  • 腫瘍摘出により経腟分娩し得た腟粘膜下Angiomyofibroblastoma合併妊娠の1例

    嶋田 浩志, 浅野 拓也, 齋藤 雅恵, 寺田 倫子, 岡村 直樹, 斎藤 豪

    日本産科婦人科学会雑誌   66 ( 2 )   863 - 863   2014.2

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  • 妊孕性温存希望子宮内膜癌症例に対しHolmstrom療法で経過観察している1例

    竹田 倫子, 嶋田 浩志, 沼田 佳苗, 染谷 真行, 岡村 直樹, 齋藤 豪

    日本臨床細胞学会雑誌   52 ( Suppl.2 )   535 - 535   2013.10

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  • 当院で経験した18トリソミー症候群の胎児超音波所見の検討

    嶋田 浩志, 浅野 拓也, 沼田 佳苗, 染谷 真行, 竹田 倫子, 岡村 直樹, 遠藤 俊明, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   61回   94 - 94   2013.9

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  • 胎児診断したisolated TAPVRの一例

    浅野 拓也, 嶋田 浩志, 寺田 倫子, 齋藤 雅恵, 岡村 直樹, 横澤 正人, 遠藤 俊明, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   61回   91 - 91   2013.9

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  • 最近経験した鼠径部腫瘍5症例の検討

    寺本 瑞絵, 岩崎 雅宏, 嶋田 浩志, 鈴木 利理, 竹浪 奈穂子, 染谷 真行, 田渕 雄大, 池田 桂子, 鈴木 美和, 高橋 円, 長澤 邦彦, 田中 綾一, 伊東 英樹, 斉藤 豪

    産婦人科手術   ( 24 )   159 - 159   2013.5

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  • A case of Takotsubo cardiomyopathy with severe infection

    北飛鳥, 其田一, 嶋田浩志, 松本純一, 村上真一, 寺田拡文, 長谷川宙希, 立花俊祐, 清水惠子, 若杉佳子

    市立釧路総合病院医学雑誌   25 ( 1 )   105 - 110   2013.3

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  • 診断に苦慮した卵巣悪性胚細胞腫瘍の1例

    嶋田 浩志, 田中 綾一, 岩見 菜々子, 長澤 邦彦, 伊東 英樹, 齋藤 豪

    北海道産科婦人科学会会誌   57 ( 1 )   111 - 112   2013.3

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  • Reciprocal translocation diagnosed as normal karyotype by amniotic fluid analysis: A case report

    浅野拓也, 嶋田浩志, 齋藤雅恵, 竹田倫子, 岡村直樹, 足立憲昭, 山田崇弘, 蒔田芳男, 寺本瑞絵, 遠藤俊明, 齋藤豪

    市立釧路総合病院医学雑誌   25 ( 1 )   85 - 88   2013.3

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  • 160kg高度肥満妊婦に対する帝王切開の経験

    中嶋 千紗, 馬場 剛, 森下 美幸, 金 美善, 足立 英文, 明石 祐史, 浅野 拓也, 嶋田 浩志, 杉尾 明香, 石岡 伸一, 遠藤 俊明, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   60回   87 - 87   2012.9

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  • 腹腔鏡下に診断、摘出し得た異所性卵巣成熟嚢胞性奇形腫の一例

    齋藤 雅恵, 明石 祐史, 嶋田 浩志, 浅野 拓也, 竹田 倫子, 岡村 直樹

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   60回   131 - 131   2012.9

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  • 母児ともに救命し得た大動脈解離合併妊娠の3例

    嶋田 浩志, 岡村 直樹, 染谷 真行, 齋藤 雅恵, 竹田 倫子, 浅野 拓也, 明石 祐史, 馬場 剛, 石岡 伸一, 遠藤 俊明, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   60回   90 - 90   2012.9

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  • 羊水検査で正常核型と診断された不均衡型転座の児の1例

    浅野 拓也, 嶋田 浩志, 齋藤 雅恵, 竹田 倫子, 岡村 直樹, 足立 憲昭, 山田 崇弘, 蒔田 芳男, 寺本 瑞絵, 遠藤 俊明, 齋藤 豪

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   60回   102 - 102   2012.9

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  • 直腸原発GISTが疑われた小骨盤腔内巨大腫瘍の1例

    宮尾 則臣, 石坂 篤, 嶋田 浩志, 畠山 陽介, 川上 賢太郎, 今 信一郎

    市立室蘭総合病院医誌   36 ( 1 )   68 - 69   2011.10

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  • 胸膜病変を有し局所麻酔下胸腔鏡検査が診断の契機となったマントル細胞リンパ腫の1例

    一色 裕之, 佐藤 修司, 川上 賢太郎, 内藤 崇史, 久保 俊之, 中垣 卓, 清水 晴夫, 金戸 宏行, 近藤 哲夫, 吉川 匠, 小林 智史, 澤田 格, 今 信一郎, 嶋田 浩志, 柾木 喜晴

    市立室蘭総合病院医誌   36 ( 1 )   5 - 9   2011.10

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Awards

  • Excellent Paper Award for Young Researchers

    2018.10   Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer.

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  • 北海道産科婦人科学会学術奨励賞

    2017.10   北海道産科婦人科学会  

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  • 第48回日本分子形態学会学術集会優秀演題賞

    2016.9   日本分子形態学会   LSR/YAP/AMOT/merlinによる子宮内膜癌の悪性化への関与

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Research Projects

  • Investigation for pathogenesis of endometriosis with a novel onset model

    Grant number：19K18674  2019.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Shimada Hiroshi

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    We investigated for pathogenesis of endometriosis focusing on tight junction protein, LSR/angulin-1 and cellular signal transduction related to progression of endometriosis. In results, we reported that LSR/angulin-1 was responsible for cellular barrier, migration and division in normal endometrial epithelial cells. Moreover, we found that one of tight junction protein, Cingulin was responsible for cellular division in normal endometrial epithelial cells.

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