Updated on 2026/07/10

写真a

 
YOKOTA Harumasa
 
Organization
School of Medicine Department of Ophthalmology Professor
Title
Professor
External link

Research Interests

  • Diabetic retinopathy

  • Peptide vaccine

  • Prorenin

Research Areas

  • Life Science / Ophthalmology  / Diabetic retinopathy, Prorenin, Peptide vaccine

Papers

  • Fenofibrate Nano-Eyedrops Ameliorate Retinal Blood Flow Dysregulation and Neurovascular Coupling in Type 2 Diabetic Mice Reviewed

    Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Masahisa Watanabe, Satoru Yamagami, Taiji Nagaoka

    Pharmaceutics   2022.2

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  • Evaluation of OCT image quality in gas-filled eyes using four OCT devices. International journal

    Mitsuru Otsubo, Tomoko Ro-Mase, Shun Konno, Ami Konno, Harumasa Yokota, Taiji Nagaoka

    International journal of retina and vitreous   2026.6

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    PURPOSE: To compare optical coherence tomography (OCT) image quality obtained on postoperative day 1 under intraocular gas tamponade using four OCT devices, including two swept-source OCT (SS-OCT) and two spectral-domain OCT (SD-OCT) systems. METHODS: This retrospective study included 30 consecutive eyes of 30 patients who underwent pars plana vitrectomy with gas tamponade between June 2025 and February 2026. On postoperative day 1, OCT imaging was performed using four devices: two SS-OCT systems (DRI OCT Triton and PLEX Elite 9000) and two SD-OCT systems (RTVue XR Avanti and SPECTRALIS OCT). OCT image quality was graded using a 5-point scale by two masked graders, and the mean score was used for analysis. The primary analysis compared image quality scores among devices in 25 eyes with macular hole using the Friedman test with Bonferroni correction. RESULTS: The mean patient age was 70.0 ± 8.7 years, and 13 patients (43.3%) were male. The median (interquartile range) image quality scores in macular hole cases (n = 25) were 5.0 (4.0-5.0) for Triton, 5.0 (4.0-5.0) for Plex Elite, 4.0 (4.0-5.0) for Avanti, and 2.0 (1.0-3.0) for Spectralis. Image quality scores differed significantly among the four devices (Friedman test, p < 0.001). CONCLUSIONS: Under intraocular gas tamponade, the SD-OCT device Avanti demonstrated relatively preserved image quality. These findings suggest that device-specific acquisition characteristics, beyond wavelength differences, substantially influence OCT image quality in gas-filled eyes. These findings may assist clinicians in selecting appropriate OCT devices for reliable postoperative assessment under gas tamponade.

    DOI： 10.1186/s40942-026-00879-2

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  • Endoscope-Assisted Vitrectomy for Bleb-Related Endophthalmitis: A Case Series. International journal

    Mitsuru Otsubo, Shun Konno, Ami Konno, Harumasa Yokota, Taiji Nagaoka

    Retinal cases & brief reports   2026.1

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    PURPOSE: To report three cases of bleb-related endophthalmitis (BRE) treated with endoscope-assisted vitrectomy and to describe the surgical approach and clinical outcomes. METHODS: We retrospectively reviewed three patients who developed BRE after glaucoma filtering surgery. All patients underwent pars plana vitrectomy (PPV) combined with endoscopic guidance using a 25-gauge endoscope, removal of avascular filtering blebs. Intraoperative findings, postoperative courses, and visual outcomes were evaluated. RESULTS: Endoscope-assisted vitrectomy enabled visualization of the peripheral vitreous despite corneal edema. In all cases, the infection resolved without recurrence. Postoperative visual acuity improved and exceeded previously reported averages. In one case, endoscopy revealed peripheral retinal degeneration, which was treated intraoperatively with laser photocoagulation, thereby preventing retinal detachment. CONCLUSIONS: Endoscope-assisted vitrectomy may be a useful surgical approach for treating BRE, particularly in cases complicated by corneal edema. The technique allows precise peripheral vitreous removal and facilitates early identification of retinal pathology.

    DOI： 10.1097/ICB.0000000000001867

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  • Author Correction: Effects of switching from intravitreal injection of aflibercept to faricimab on ocular blood flow in patients with diabetic macular edema. International journal

    Yoshinari Saima, Harumasa Yokota, Akifumi Kushiyama, Junya Hanaguri, Akira Ohno, Koyo Takase, Ruri Sugiyama, Kimimasa Muranaka, Satoru Yamagami, Taiji Nagaoka

    Scientific reports   15 ( 1 )   19313 - 19313   2025.6

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  • Effects of switching from intravitreal injection of aflibercept to faricimab on ocular blood flow in patients with diabetic macular edema. International journal

    Yoshinari Saima, Harumasa Yokota, Akifumi Kushiyama, Junya Hanaguri, Akira Ohno, Koyo Takase, Ruri Sugiyama, Kimimasa Muranaka, Satoru Yamagami, Taiji Nagaoka

    Scientific reports   14 ( 1 )   13798 - 13798   2024.6

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    We assessed the short-term effects of switching from intravitreal aflibercept (IVA) to intravitreal faricimab (IVF) on ocular blood flow in patients with treatment-resistant diabetic macular edema (DME). The medical records of 15 patients with DME who had received IVA injection ≥ 3 months before were retrospectively reviewed. The best-corrected visual acuity, central macular thickness (CMT) on optical coherence tomography, and mean blur rate (MBR) of all disc areas on laser speckle flowgraphy were measured before, 1 week after, and 4 weeks after IVA and IVF, respectively. The changes in visual acuity showed no significant difference after switching from IVA to IVF (P = 0.732). The mean CMT decreased significantly during the follow-up period (both P < 0.001). MBR showed no significant difference during the follow-up period (P = 0.26). However, it decreased significantly 4 weeks after IVF (P = 0.01) compared with the baseline value, but not 4 weeks after IVA (P = 0.074). A significant association was observed between decreased MBR and decreased CMT in patients who received IVF (correlation coefficient: 0.501, P = 0.005) but not in those who received IVA (P = 0.735). Thus, IVF maintained ocular blood flow reduction, although no significant differences in visual acuity and CMT changes were observed compared to IVA.

    DOI： 10.1038/s41598-024-63435-8

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  • 両眼に発症した研究用YAGレーザーによる外傷性黄斑円孔の1例

    高瀬 公陽, 横田 陽匡, 佐伯 忠賜朗, 岩崎 将典, 花栗 潤哉, 秋山 彩香, 山本 瑠璃, 山上 聡, 長岡 泰司

    眼科臨床紀要   16 ( 11 )   807 - 808   2023.11

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  • 日大板橋病院における裂孔原性網膜剥離の治療成績

    横田 陽匡, 佐伯 忠賜朗, 岩崎 将典, 花栗 潤哉, 秋山 彩香, 大野 皓, 高瀬 公陽, 山本 瑠璃, 山上 聡, 長岡 泰司

    眼科臨床紀要   16 ( 11 )   804 - 805   2023.11

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  • 裂孔原性網膜剥離に対する硝子体術後の黄斑円孔

    岩崎 将典, 秋山 彩香, 花崎 浩継, 朝生 浩, 佐伯 忠賜朗, 横田 陽匡, 山上 聡, 長岡 泰司

    眼科臨床紀要   16 ( 11 )   809 - 809   2023.11

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  • 両眼に発症した研究用YAGレーザーによる外傷性黄斑円孔の1例

    高瀬 公陽, 横田 陽匡, 佐伯 忠賜朗, 岩崎 将典, 花栗 潤哉, 秋山 彩香, 山本 瑠璃, 山上 聡, 長岡 泰司

    眼科臨床紀要   16 ( 4 )   318 - 319   2023.4

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  • 糖尿病黄斑浮腫に対するアフリベルセプトおよびファリシマブ投与の眼循環への影響

    齊間 至成, 横田 陽匡, 櫛山 暁史, 花栗 潤哉, 大野 皓, 高瀬 公陽, 杉山 瑠璃, 村中 公正, 山上 聡, 長岡 泰司

    日本眼科学会雑誌   127 ( 臨増 )   279 - 279   2023.3

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  • Rapamycinによるブタ摘出網膜動脈血管拡張作用の検討

    大野 皓, 横田 陽匡, 櫛山 暁史, 花栗 潤哉, 渡部 昌久, 高瀬 公陽, 山上 聡, 長岡 泰司

    日本眼科学会雑誌   127 ( 臨増 )   251 - 251   2023.3

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  • 2型糖尿病マウスにおける新規治療薬の蛍光免疫染色による酸化ストレス評価

    花栗 潤哉, 杉山 瑠璃, 櫛山 暁史, 横田 陽匡, 高瀬 公陽, 櫛山 櫻, 山上 聡, 長岡 泰司

    日本眼科学会雑誌   127 ( 臨増 )   252 - 252   2023.3

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  • 2型糖尿病マウスでは、網膜血流調節不全が神経網膜機能障害に先行する(Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice)

    花栗 潤哉, 横田 陽匡, 渡部 昌久, 山上 聡, 櫛山 暁史, KouLih, 長岡 泰司

    糖尿病合併症   36 ( Suppl.1 )   107 - 107   2022.9

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  • Comprehensive assessment of systemic arteriosclerosis in relation to the ocular resistive index in acute coronary syndrome patients Reviewed

    Yasunari Ebuchi, Taiji Nagaoka, Daisuke Fukamachi, Keisuke Kojima, Naotaka Akutsu, Nobuhiro Murata, Yuki Saito, Daisuke Kitano, Harumasa Yokota, Satoru Yamagami, Yasuo Okumura

    Sci Rep   2022.2

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  • Beneficial Effect of Long-Term Administration of Supplement With Trapa Bispinosa Roxb. and Lutein on Retinal Neurovascular Coupling in Type 2 Diabetic Mice Reviewed

    Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Masahisa Watanabe, Satoru Yamagami, Taiji Nagaoka

    Front Physiol   2022.2

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  • The Effect of Sodium-Dependent Glucose Cotransporter 2 Inhibitor Tofogliflozin on Neurovascular Coupling in the Retina in Type 2 Diabetic Mice Reviewed

    Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Masahisa Watanabe, Satoru Yamagami, Taiji Nagaoka

    Int J Mol Sci   2022.1

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  • Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes

    Harumasa Yokota, Hiroki Hayashi, Junya Hanaguri, Satoru Yamagami, Akifumi Kushiyama, Hironori Nakagami, Taiji Nagaoka

    PLoS One   2022.1

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  • Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice Reviewed

    Junya Hanaguri, Harumasa Yokota, Masahisa Watanabe, Satoru Yamagami, Akifumi Kushiyama, Lih Kuo, Taiji Nagaoka

    Sci Rep   2021.9

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  • Development of Stage 4 Macular Hole after Spontaneous Closure in a Patient with Stage 2 Macular Hole and a Lamellar Macular Hole-Associated Epiretinal Proliferation

    Masahisa Watanabe, Harumasa Yokota, Hiroshi Aso, Hirotsugu Hanazaki, Junya Hanaguri, Satoru Yamagami, Taiji Nagaoka

    Case Rep Ophthalmol   2021.7

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  • Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment Reviewed

    Harumasa Yokota, Taiji Nagaoka, Hidetaka Noma, Akemi Ofusa, Tomoe Kanemaki, Hiroshi Aso, Hirotsugu Hanazaki, Satoru Yamagami, Masahiko Shimura

    Sci Rep   2021.7

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  • The kebab technique uses a bipolar pencil to retrieve a dropped nucleus of the lens via a small incision Reviewed International journal

    Hiroshi Aso, Harumasa Yokota, Hirotsugu Hanazaki, Satoru Yamagami, Taiji Nagaoka

    Sci Rep   11 ( 1 )   7897 - 7897   2021.4

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    We developed a new method to retrieve a dropped nucleus of the lens via a small incision using bipolar pencils, the kebab technique, to solve the lack of small-gauge fragmatomes, and the expense and toxicity of perfluorocarbon liquids (PFCL). A total of 8 eyes in 6 patients underwent this technique and were reviewed. After vitrectomy, the dropped nucleus of the lens was lifted from the retina by adhesion with a bipolar pencil, and phacoemulsification was performed while rotating the lens. The outcome measures were best-corrected visual acuity (BCVA), intraocular pressure (IOP), and corneal endothelial cell density before and after surgery. Surgical indications included zonular weakness, trauma, acute angle closure attack, and phacolytic glaucoma. At 1 month, BCVA improved from a mean (standard deviation, SD) 1.67 logMAR (0.90) to 1.14 logMAR (1.01). The mean preoperative IOP was 24.5 (16.8) mmHg and postoperative IOP was 11.0 (2.8) mmHg. The mean preoperative corneal endothelial cell count was 2600 (322) cells/mm2 (one eye was unmeasurable) and postoperative corneal endothelial cell count was 2387 (431) cells/mm2. There were no postoperative complications. The retrieval of a dropped nucleus of the lens using a bipolar pencil enables small incisions without using PFCL.

    DOI： 10.1038/s41598-021-87022-3

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  • Evaluation of ocular blood flow over time in a treated retinal arterial macroaneurysm using laser speckle flowgraphy International journal

    Hirotsugu Hanazaki, Harumasa Yokota, Hiroshi Aso, Satoru Yamagami, Taiji Nagaoka

    Am J Ophthalmol Case Rep   21   101022 - 101022   2021.2

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    Purpose: To report the changes over time in ocular blood flow quantified by laser speckle flowgraphy (LSFG) in a treated large retinal arterial macroaneurysm (RAM). Observations: A 72-year old female presented with sudden decreased vision in the left eye. Fundus examination revealed a RAM and vitreous hemorrhage (VH), which worsened over one month. A vitrectomy was performed to remove the VH, with 20% sulfur hexafluoride injected into the vitreous cavity. The VH recurred two weeks later and the RAM was found to have enlarged from one-quarter disc diameter (DD) to three DDs during a second vitrectomy. The RAM subsequently shrunk spontaneously to one DD without recurrent VH during the following 2 weeks. Beginning 4 weeks after the second vitrectomy we performed serial LSFG examinations of the RAM and found that the mean blur rate (MBR) of the RAM and retinal flow volume (RFV) in both the feeding arteriole and draining venule decreased as the RAM continued to involute. Conclusions and importance: MBR and arteriolar and venular RFV measured by LSFG decreased with RAM involution. Longitudinal followup of blood flow by LSFG may be useful for noninvasive evaluation of the stability of RAMs.

    DOI： 10.1016/j.ajoc.2021.101022

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  • Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes Reviewed

    Masaki Nagaya, Koki Hasegawa, Masahito Watanabe, Kazuaki Nakano, Kazutoshi Okamoto, Takeshi Yamada, Ayuko Uchikura, Kenji Osafune, Harumasa Yokota, Taiji Nagaoka, Hitomi Matsunari, Kazuhiro Umeyama, Eiji Kobayashi, Hiromitsu Nakauchi, Hiroshi Nagashima

    BMJ Open Diabetes Res Care   2020.11

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  • Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy Reviewed

    Junya Hanaguri, Harumasa Yokota, Masahisa Watanabe, Lih Kuo, Satoru Yamagami, Taiji Nagaoka

    Sci Rep   10 ( 1 )   2020.11

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    <title>Abstract</title>This study aimed to evaluate longitudinal changes in retinal blood flow in response to flicker stimulation and systemic hyperoxia in mice using a laser speckle flowgraphy (LSFG-Micro). The retinal blood flow in vascular area surrounding the optic nerve head was measured in 8-week-old male mice every 2 weeks until age 20-week. The coefficient of variation of retinal blood flow under resting condition was analyzed every 2 weeks to validate the consistency of the measurement. On day 1 of the experiment, retinal blood flow was assessed every 20 s for 6 min during and after 3 min flicker light (12 Hz) stimulation; on day 2, retinal blood flow was measured every minute for 20 min during and after 10 min systemic hyperoxia; and on day 3, electroretinography (ERG) was performed. Body weight, systemic blood pressure, and ocular perfusion pressure increased significantly with age, but the resting retinal blood flow and ERG parameters remained unchanged. Retinal blood flow significantly increased with flicker stimulation and decreased with systemic hyperoxia, independent of age. The LSFG-Micro provides consistent and reproducible retinal blood flow measurement in adult mice. Longitudinal assessments of retinal blood flow in response to flicker stimulation and systemic hyperoxia may be useful indexes for noninvasive monitoring of vascular function in retinas.

    Other Link： http://www.nature.com/articles/s41598-020-75296-y

    DOI： 10.1038/s41598-020-75296-y

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  • Transforming Growth Factor-β Signaling Cascade Induced by Mechanical Stimulation of Fluid Shear Stress in Cultured Corneal Epithelial Cells Reviewed

    Tsugiaki Utsunomiya, Akihiro Ishibazawa, Taiji Nagaoka, Kazuomi Hanada, Harumasa Yokota, Nobuhito Ishii, Akitoshi Yoshida

    Invest Ophthalmol Vis Sci   2016.11

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  • Characteristics of Retinal Neovascularization in Proliferative Diabetic Retinopathy Imaged by Optical Coherence Tomography Angiography Reviewed

    Akihiro Ishibazawa, Taiji Nagaoka, Harumasa Yokota, Atsushi Takahashi, Tsuneaki Omae, Young-Seok Song, Tatsuhisa Takahashi, Akitoshi Yoshida

    Invest Ophthalmol Vis Sci   2016.11

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  • Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury Reviewed

    Esraa Shosha, Zhimin Xu, Harumasa Yokota, Alan Saul, Modesto Rojas, R William Caldwell, Ruth B Caldwell, S Priya Narayanan

    Cell Death Dis   2016.11

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  • SYSTEMIC RISK FACTORS IN BILATERAL PROLIFERATIVE DIABETIC RETINOPATHY REQUIRING VITRECTOMY Reviewed

    Young-Seok Song, Taiji Nagaoka, Tsuneaki Omae, Harumasa Yokota, Atsushi Takahashi, Akitoshi Yoshida

    Retina   2016.7

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  • Radial Peripapillary Capillary Network Visualized Using Wide-Field Montage Optical Coherence Tomography Angiography Reviewed

    Tomoko Mase, Akihiro Ishibazawa, Taiji Nagaoka, Harumasa Yokota, Akitoshi Yoshida

    Invest Ophthalmol Vis Sci   57 ( 9 )   2016.7

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    DOI： 10.1167/iovs.15-18877.

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  • Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury Reviewed

    Akito Shimouchi, Harumasa Yokota, Shinji Ono, Chiemi Matsumoto, Toshihiro Tamai, Hiroko Takumi, Subbadra P. Narayanan, Shoji Kimura, Hiroya Kobayashi, Ruth B. Caldwell, Taiji Nagaoka, Akitoshi Yoshida

    JAPANESE JOURNAL OF OPHTHALMOLOGY   60 ( 1 )   51 - 61   2016.1

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    DOI： 10.1007/s10384-015-0415-z

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  • Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma Reviewed

    Y Ha, H Liu, Z Xu, H Yokota, S P Narayanan, T Lemtalsi, S B Smith, R W Caldwell, R B Caldwell, W Zhang

    Cell Death Dis   2015.10

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  • Imaging of the Corneal Subbasal Whorl-like Nerve Plexus: More Accurate Depiction of the Extent of Corneal Nerve Damage in Patients With Diabetes Reviewed

    Tsugiaki Utsunomiya, Taiji Nagaoka, Kazuomi Hanada, Tsuneaki Omae, Harumasa Yokota, Atsuko Abiko, Masakazu Haneda, Akitoshi Yoshida

    Invest Ophthalmol Vis Sci   2015.8

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  • Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study Reviewed

    Akihiro Ishibazawa, Taiji Nagaoka, Atsushi Takahashi, Tsuneaki Omae, Tomofumi Tani, Kenji Sogawa, Harumasa Yokota, Akitoshi Yoshida

    Am J Ophthalmol   2015.7

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  • Role of neuronal nitric oxide synthase in regulating retinal blood flow during flicker-induced hyperemia in cats Reviewed

    Takafumi Yoshioka, Taiji Nagaoka, Youngseok Song, Harumasa Yokota, Tomofumi Tani, Akitoshi Yoshida

    Invest Ophthalmol Vis Sci   2015.5

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  • Temporal posttraumatic limited ocular movement with suspected trapdoor fracture Reviewed

    Young-Seok Song, Harumasa Yokota, Haruna Ito, Akitoshi Yoshida

    Clin Ophthalmol   2014.8

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  • Low shear stress up-regulation of proinflammatory gene expression in human retinal microvascular endothelial cells Reviewed

    Akihiro Ishibazawa, Taiji Nagaoka, Harumasa Yokota, Shinji Ono, Akitoshi Yoshida

    Exp Eye Res   2013.11

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  • Correlation between plasma pentosidine concentrations and retinal hemodynamics in patients with type 2 diabetes Reviewed

    Eiichi Sato, Taiji Nagaoka, Harumasa Yokota, Atsushi Takahashi, Akitoshi Yoshida

    Am J Ophthalmol   2012.3

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  • Neuroprotection from Retinal Ischemia/Reperfusion Injury by NOX2 NADPH Oxidase Deletion Reviewed

    Harumasa Yokota, Subhadra P. Narayanan, Wenbo Zhang, Hua Liu, Modesto Rojas, Zhimin Xu, Tahira Lemtalsi, Taiji Nagaoka, Akitoshi Yoshida, Steven E. Brooks, Robert W. Caldwell, Ruth B. Caldwell

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   52 ( 11 )   8123 - 8131   2011.10

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    DOI： 10.1167/iovs.11-8318

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  • Higher levels of prorenin predict development of diabetic retinopathy in patients with type 2 diabetes Reviewed

    Harumasa Yokota, Taiji Nagaoka, Tomofumi Tani, Atsushi Takahashi, Eiichi Sato, Yuji Kato, Akitoshi Yoshida

    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM   12 ( 3 )   290 - 294   2011.9

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    DOI： 10.1177/1470320310391327

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  • Hyperoxia Therapy of Pre-Proliferative Ischemic Retinopathy in a Mouse Model Reviewed

    Wenbo Zhang, Harumasa Yokota, Zhimin Xu, Subhadra P. Narayanan, Lauren Yancey, Akitoshi Yoshida, Dennis M. Marcus, Robert W. Caldwell, Ruth B. Caldwell, Steven E. Brooks

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   52 ( 9 )   6384 - 6395   2011.8

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    DOI： 10.1167/iovs.11-7666

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  • Macular hole formation in fellow eyes with a perifoveal posterior vitreous detachment of patients with a unilateral macular hole Reviewed

    Atsushi Takahashi, Akitoshi Yoshida, Taiji Nagaoka, Hiroyuki Kagokawa, Yuji Kato, Akira Takamiya, Eiichi Sato, Harumasa Yokota, Satoshi Ishiko, Hiroyuki Hirokawa

    Am J Ophthalmol   2011.6

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  • Impaired retinal circulation in patients with type 2 diabetes mellitus: retinal laser Doppler velocimetry study Reviewed

    Taiji Nagaoka, Eiichi Sato, Atsushi Takahashi, Harumasa Yokota, Kenji Sogawa, Akitoshi Yoshida

    Invest Ophthalmol Vis Sci   2010.12

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  • Effect of aging on retinal circulation in normotensive healthy subjects Reviewed

    Taiji Nagaoka, Eiichi Sato, Atsushi Takahashi, Kenji Sogawa, Harumasa Yokota, Akitoshi Yoshida

    Exp Eye Res   2009.12

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  • Prorenin levels in retinopathy of prematurity Reviewed International journal

    HARUMASA Yokota, TAIJI Nagaoka, FUMIHIKO Mori, TAIICHI Hikichi, HIROMICHI Hosokawa, HIROSHI Tanaka, YUICHI Ishida, FUMIAKI Suzuki, AKITOSHI Yoshida

    American Journal of Ophthalmology   143 ( 3 )   531 - 533   2007

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  • Serum prorenin levels and diabetic retinopathy in type 2 diabetes: new method to measure serum level of prorenin using antibody activating direct kinetic assay Reviewed

    H Yokota, F Mori, K Kai, T Nagaoka, N Izumi, A Takahashi, T Hikichi, A Yoshida, F Suzuki, Y Ishida

    BRITISH JOURNAL OF OPHTHALMOLOGY   89 ( 7 )   871 - 873   2005.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1136/bjo.2004.056580

    Web of Science

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  • Pulsatile ocular blood flow: changes associated with scleral buckling International journal

    HARUMASA Yokota, FUMIHIKO Mori, TAIJIi Nagaoka, RYOICHI Sugawara, AKITOSHI Yoshida.

    Japan Journal of Ophthalmology   49 ( 2 )   162 - 165   2005

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10384-004-0161-0

    Web of Science

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  • Pulsatile ocular blood flow is unaffected in type 2 diabetes mellitus Reviewed

    Fumihiko Mori, Harumasa Yokota, Taiji Nagaoka, Suguru Konno, Hiroyuki Kagokawa, Taiichi Hikichi, Akitoshi Yoshida

    Jpn J Ophthalmol   2003.11

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    Language：English  

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Books

  • 角膜混濁眼の硝子体手術に用いる人工角膜を用いた手術について教えてください

    （ Role： Sole author）

    金原出版 

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    Language：Japanese  

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MISC

  • Serum prorenin levels are not associated with ocular diseases in non-diabetic subjects

    Harumasa Yokota, Taiji Nagaoka, Eiichi Sato, Atsushi Takahashi, Akito Shimouchi, Akitoshi Yoshida

    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM   16 ( 1 )   153 - 158   2015.3

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Presentations

  • プロレニンを標的とした治療ワクチンの２型糖尿病モデルでの基礎的検討

    日本眼科学会総会  2018.4 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 中心窩を含む裂孔原性網膜剥離に対する硝子体手術後の眼循環動態

    2019 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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Research Projects

  • The role of inflammatory Cell Death (Pyroptosis) in the Pathogenesis of Diabetic Retinopathy and Novel Nanoparticle Eye Drop Therapy

    Grant number：25K12867  2025.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • Overcoming Diabetic Retinopathy through Local Control of Oxidative Stress

    Grant number：24K12772  2024.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • Elucidation of regulatory mechanism of neurovascular coupling interaction in retinal circulation and clinical application for early diagnosis of diabetic retinopathy

    Grant number：25293352  2013.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    NAGAOKA Taiji

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    Grant amount：\15340000 （ Direct Cost: \11800000 、 Indirect Cost：\3540000 ）

    We have revealed that 1) retinal glial cells may be involved with the retinal neurovascular coupling during systemic hyperoxia 2) EDHF may be involved with histamine-induced vasodilation in retinal porcine arterioles 3) habitual smoking may have some influences on retinal circulation in patients with diabetic retinopathy.

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  • 糖尿病網膜症の発症予防のためのワクチン治療の開発

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    Authorship：Principal investigator  Grant type：Competitive

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  • 糖転移ヘスペリジンによる糖尿病網膜症新規治療薬の開発

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    Authorship：Principal investigator  Grant type：Competitive

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  • プロレニンを標的とした糖尿病網膜症の新規治療薬の開発

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    Authorship：Principal investigator  Grant type：Competitive

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