Misc - KOJIMA Takashi

3細胞間タイト結合蛋白LSRはHippo pathwayを介して子宮内膜癌の悪性化に関与している

嶋田 浩志, 郷久 晴朗, 金野 匠, 高橋 駿太, 畠山 翔翼, 幸野 貴之, 田中 綾一, 寺本 瑞絵, 岩崎 雅宏, 小島 隆, 齋藤 豪

日本婦人科腫瘍学会雑誌 ( (公社)日本婦人科腫瘍学会 )  34 ( 3 ) 416 - 416  2016.06

ヒト鼻粘膜上皮バリアにおけるp63の役割

小島 隆, 角木 拓也, 金子 躍人, 高野 賢一, 小笠原 徳子, 横田 伸一, 氷見 徹夫, 幸野 貴之

日本細胞生物学会大会講演要旨集 ( (一社)日本細胞生物学会 )  68回   63 - 63  2016.05

温度感受性マウス内耳有毛前駆細胞におけるMetforminおよびHDAC阻害剤による3細胞間タイト結合蛋白の誘導

角木 拓也, 金子 躍人, 高野 賢一, 氷見 徹夫, 幸野 貴之, 小島 隆

日本細胞生物学会大会講演要旨集 ( (一社)日本細胞生物学会 )  68回   99 - 99  2016.05

頭頸部扁平上皮癌におけるp63/GATA-3経路を介したタイト結合分子JAM-Aの発現調節機構

角木 拓也, 黒瀬 誠, 高野 賢一, 近藤 敦, 小幡 和史, 野村 一顕, 宮田 遼, 金野 匠, 高橋 駿太, 畠山 翔翼, 幸野 貴之, 氷見 徹夫, 小島 隆

日本細胞生物学会大会講演要旨集 ( (一社)日本細胞生物学会 )  67回   134 - 134  2015.06

頭頸部扁平上皮癌細胞株におけるp63を介したタイト結合分子JAM-Aの発現調節機構

高橋 駿太, 角木 拓也, 宮田 遼, 野村 一顕, 黒瀬 誠, 近藤 敦, 高野 賢一, 幸野 貴之, 氷見 徹夫, 小島 隆

日本細胞生物学会大会講演要旨集 ( (一社)日本細胞生物学会 )  66回   140 - 140  2014.05

ROLE OF TIGHT JUNCTIONS IN SIGNAL TRANSDUCTION: AN UPDATE

Kenichi Takano, Takashi Kojima, Norimasa Sawada, Tetsuo Himi

EXCLI JOURNAL ( EXCLI JOURNAL MANAGING OFFICE )  13   1145 - 1162  2014

Book review, literature introduction, etc.  

　View Summary

Tight junctions (TJs), which are the most apically located of the intercellular junctional complexes, have a barrier function and a fence function. Recent studies show that they also participate in signal transduction mechanisms. TJs are modulated by intracellular signaling pathways including protein kinase C, mitogen-activated protein kinase, and NF-kappa B, to affect the epithelial barrier function in response to diverse stimuli. TJs are also regulated by various cytokines, growth factors, and hormones via signaling pathways. To investigate the regulation of TJ molecules via signaling pathways in human epithelial cells under normal and pathological conditions, we established a novel model of human telomerase reverse transcriptase-transfected human epithelial cells. In this review, we describe the recent progress in our understanding of the role of TJs for signal transduction under normal conditions in upper airway epithelium, pancreatic duct epithelial cells, hepatocytes, and endometrial epithelial cells, and in pathological conditions including cancer and infection.

膵癌の上皮間葉移行におけるタイト結合分子claudin‐1に対するPKCα阻害剤の効果

及能大輔, 小島隆, 河野剛, 山口洋志, 伊東竜哉, 今村将史, 木村康利, 澤田典均, 平田公一

日本消化器癌発生学会総会プログラム・抄録集   25th   86  2014

J-GLOBAL

Expression of tricellulin in epithelial cells and non-epithelial cells

Takashi Kojima, Takafumi Ninomiya, Takumi Konno, Takayuki Kohno, Masahiko Taniguchi, Norimasa Sawada

HISTOLOGY AND HISTOPATHOLOGY ( F HERNANDEZ )  28 ( 11 ) 1383 - 1392  2013.11

Book review, literature introduction, etc.  

　View Summary

Tricellulin is the first molecular component of tricellular tight junctions at tricellular contacts where three epithelial cells meet, and it is required for the their formation and maintenance of the epithelial barrier. Tricellulin binds other tight junction proteins, and its expression and distribution are affected by the bicellular tight junction protein occludin and lipolysis-stimulated lipoprotein receptor (LSR) which is expressed at tricellular contacts. Tricellulin is also detected in endothelial cells, neurons, microglia and astrocytes. Here, we focused tricellulin expression in various types of epithelial cells, nasal epithelial cells, pancreatic duct epithelial cells cells and hepatocytes, and non-epithelial cells, dendritic cells and Schwann cells, compared to expression of the bicellular tight junction protein occludin and LSR, and discuss the regulation and the role of tricellulin in cellular specificity.

膵癌組織および膵癌細胞株におけるタイト結合分子tricellulinの核への局在

村田 雅樹, 高澤 啓, 田中 敏, 小島 隆, 澤田 典均

日本病理学会会誌 ( (一社)日本病理学会 )  102 ( 1 ) 473 - 473  2013.04

胆道癌におけるclaudin18、maspin、p53の免疫組織化学的検討

計良 淑子, 高澤 啓, 村田 雅樹, 荻野 次郎, 及能 大輔, 中西 勝也, 田中 敏, 小島 隆, 長谷川 匡, 澤田 典均

日本病理学会会誌 ( (一社)日本病理学会 )  102 ( 1 ) 471 - 471  2013.04

PKCα阻害剤は膵癌細胞のEMTにおけるタイト結合分子claudin‐1の低下を抑制する

及能大輔, 小島隆, 山口洋志, 伊東竜哉, 信岡隆幸, 今村将史, 木村康利, 澤田典均, 平田公一

日本外科学会雑誌   114   683  2013.03

J-GLOBAL

Regulation of Tight Junctions in Upper Airway Epithelium

Takashi Kojima, Mitsuru Go, Ken-ichi Takano, Makoto Kurose, Tsuyoshi Ohkuni, Jun-ichi Koizumi, Ryuta Kamekura, Noriko Ogasawara, Tomoyuki Masaki, Jun Fuchimoto, Kazufumi Obata, Satoshi Hirakawa, Kazuaki Nomura, Takashi Keira, Ryou Miyata, Nobuhiro Fujii, Hiroyuki Tsutsumi, Tetsuo Himi, Norimasa Sawada

BIOMED RESEARCH INTERNATIONAL ( HINDAWI PUBLISHING CORPORATION )   2013

Book review, literature introduction, etc.  

　View Summary

The mucosal barrier of the upper respiratory tract including the nasal cavity, which is the first site of exposure to inhaled antigens, plays an important role in host defense in terms of innate immunity and is regulated in large part by tight junctions of epithelial cells. Tight junction molecules are expressed in both M cells and dendritic cells as well as epithelial cells of upper airway. Various antigens are sampled, transported, and released to lymphocytes through the cells in nasal mucosa while they maintain the integrity of the barrier. Expression of tight junction molecules and the barrier function in normal human nasal epithelial cells (HNECs) are affected by various stimuli including growth factor, TLR ligand, and cytokine. In addition, epithelial-derived thymic stromal lymphopoietin (TSLP), which is a master switch for allergic inflammatory diseases including allergic rhinitis, enhances the barrier function together with an increase of tight junction molecules in HNECs. Furthermore, respiratory syncytial virus infection in HNECs in vitro induces expression of tight junction molecules and the barrier function together with proinflammatory cytokine release.. is paper summarizes the recent progress in our understanding of the regulation of tight junctions in the upper airway epithelium under normal, allergic, and RSV-infected conditions.

DOI

扁桃・アデノイドはなぜあるのか？鼻はなにをしているのか？―小児の粘膜免疫・粘膜防御最前線―

氷見徹夫, 高野賢一, 山下恵司, 小笠原徳子, 正木智之, 小幡和史, 堤裕幸, 小島隆, 一宮慎吾, 澤田典均, 横田伸一

小児耳鼻咽喉科   34   239 - 244  2013

DOI

ウイルス性上気道感染での免疫応答と鼻粘膜上皮の役割

氷見徹夫, 高野賢一, 大國毅, 小笠原徳子, 正木智之, 小幡和史, 堤裕幸, 小島隆, 澤田典均, 横田伸一

耳鼻咽喉科展望   56   162 - 177  2013  [Invited]

Article, review, commentary, editorial, etc. (other)  

DOI

Regulation of Claudin-4 via Protein Kinase C Signal Pathway in Normal Human Pancreatic Duct Epithelial Cells and Cancer Cells

H. Yamaguchi, T. Kojima, D. Kyuno, T. Ito, M. Imamura, Y. Kimura, N. Sawada, K. Hirata

PANCREAS ( LIPPINCOTT WILLIAMS & WILKINS )  41 ( 7 ) 1149 - 1149  2012.10

Research paper, summary (international conference)  

Protein Kinase C-alpha Regulates Claudin-1 via Snail-dependent and -independent Pathways in Pancreatic Cancer

D. Kyuno, T. Kojima, H. Yamaguchi, T. Ito, M. Imamura, Y. Kimura, A. Takasawa, M. Murata, M. Murata, K. Hirata

PANCREAS ( LIPPINCOTT WILLIAMS & WILKINS )  41 ( 7 ) 1150 - 1150  2012.10

Research paper, summary (international conference)  

PKCαによるSnailを介した膵癌のタイト結合分子への影響(PKC-alpha regulates claudin-1 via Snail gene in pancreatic cancer)

及能 大輔, 小島 隆, 山口 洋志, 伊東 竜哉, 今村 将史, 木村 康利, 高澤 啓, 村田 雅樹, 平田 公一, 澤田 典均

日本癌学会総会記事 ( 日本癌学会 )  71回   295 - 295  2012.08

胆道癌におけるclaudin-18、Maspinの免疫組織化学的検討(Immunohistochemical investigation of claudin-18 and Maspin in biliary tract cancer)

計良 淑子, 高澤 啓, 村田 雅樹, 小島 隆, 長谷川 匡, 澤田 典均

日本癌学会総会記事 ( (一社)日本癌学会 )  71回   351 - 351  2012.08

タイト結合分子tricellulinの核における発現はヒト膵癌細胞において細胞増殖に関与している(Expression of tricellulin in the nuclei is associated with cell proliferation in human pancreatic cancer cells)

村田 雅樹, 高澤 啓, 小島 隆, 澤田 典均

日本癌学会総会記事 ( (一社)日本癌学会 )  71回   525 - 525  2012.08

ヒト膵管上皮細胞株におけるJun N-terminal kinase阻害剤によるバリア機能の亢進

金野 匠, 小島 隆, 及能 大輔, 村田 雅樹, 高澤 啓, 田中 敏, 澤田 典均

日本病理学会会誌 ( (一社)日本病理学会 )  101 ( 1 ) 438 - 438  2012.03