Misc - YAMAKAGE Michiaki

The relationship between respiratory patterns and work of breathing during halothane anesthesia with spontaneous ventilation

M Yamakage, S Kohro, Y Honma, M Edanaga, M Okanuma, A Namiki

ANESTHESIA AND ANALGESIA ( WILLIAMS & WILKINS )  84   S599 - S599  1997.02

Research paper, summary (international conference)  

Onset of vecuronium and pancuronium neuromuscular block with and without severe cardiac valvular disease

H Iwasaki, M Yamauchi, H Tsuchida, M Yamakage, H Ohmori, A Namiki

ANESTHESIA AND ANALGESIA ( WILLIAMS & WILKINS )  84   S503 - S503  1997.02

Research paper, summary (international conference)  

Thromboelastogram showing an undesirable effect of platelet transfusion on blood coagulability and fibrinolysis in a patient with aplastic anemia

S. Kohro, M. Yamakage, T. Takeda, A. Namiki

Journal of Anesthesia   11 ( 4 ) 303 - 306  1997

DOI

Role of intracellular Ca2+ stores in the inhibitory effect of halothane on airway smooth muscle contraction

M Yamakage, S Kohro, A Namiki

ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS )  85 ( 3A ) A1128 - A1128  1996.09

Research paper, summary (international conference)  

EFFECTS OF HALOTHANE ON INTRACELLULAR CA2+ REGULATORY SYSTEMS IN HUMAN PLATELET

S KOHRO, M YAMAKAGE, A NAMIKI

ANESTHESIOLOGY ( LIPPINCOTT-RAVEN PUBL )  83 ( 3A ) A309 - A309  1995.09

Research paper, summary (international conference)  

INHIBITION OF VOLTAGE-DEPENDENT CA2+ CHANNELS IN PORCINE TRACHEAL SMOOTH-MUSCLE BY KETAMINE, PROPOFOL, AND THIOPENTAL

M YAMAKAGE, TL CROXTON, CA HIRSHMAN

ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS )  83 ( 3A ) A1203 - A1203  1995.09

Research paper, summary (international conference)  

Patch clamp techniques to study effects of anesthetics on airway smooth muscle cells

YAMAKAGE Michiaki, CROXTON Thomas, HIRSHMAN Carol A

J Anesth   9 ( 1 ) 111 - 112  1995.02

CiNii

THE EFFECTS OF EXTRACELLULAR PH ON INTRACELLULAR PH, CA2+ AND TENSION OF CANINE TRACHEAL SMOOTH-MUSCLE STRIPS

M YAMAKAGE, S KOHRO, M YAMAUCHI, A NAMIKI

LIFE SCIENCES ( PERGAMON-ELSEVIER SCIENCE LTD )  56 ( 8 ) PL175 - PL180  1995.01

Rapid communication, short report, research note, etc. (scientific journal)  

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The effects of changes in extracellular pH (pH(o)) on intracellular Ca2+ concentration ([Ca2+](i)) or intracellular pH (pH(i)) were measured simultaneously with muscle tension in canine tracheal smooth muscle strips. [Ca2+](i) and pH(i) were measured using the fluorescent dyes fura-2 and BCECF, respectively. During high K+-induced contractions (24.2, 36.4 or 72.7 mM) at pH 7.4, pH(o) was changed to 7.8 or 7.0 with NaOH or HCl, respectively. Induced changes in pH(i) were equal to similar to 50% of the changes in pH(o). Alkalinization significantly increased [Ca2+](i) and enhanced muscle contraction at all concentrations of K+ but did not alter the relationship between muscle tension and [Ca2+](i). Acidification significantly decreased [Ca2+](i) without changing muscle tone; hence, the muscle tension - [Ca2+](i) relationship was shifted to the left. These results suggest that changes in pH(o), can alter airway smooth muscle tone by changing [Ca2+](i) and pH(i).

腹部大動脈瘤および閉塞性動脈硬化症の人工血管置換術における足底深部温の変化

山内 正憲, 山蔭 道明, 其田 一

臨床体温 ( 「臨床体温」編集委員会 )  14 ( 2 ) 51 - 55  1994.12

INHIBITION BY HALOTHANE OF VOLTAGE-DEPENDENT CA2+ CURRENTS IN PORCINE TRACHEAL SMOOTH-MUSCLE CELLS

M YAMAKAGE, TL CROXTON, CA HIRSHMAN

ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS )  81 ( 3A ) A1445 - A1445  1994.09

Research paper, summary (international conference)  

DIRECT INHIBITORY MECHANISMS OF HALOTHANE ON HUMAN PLATELET-AGGREGATION

S KOHRO, M YAMAKAGE, A NAMIKI

ANESTHESIOLOGY ( LIPPINCOTT-RAVEN PUBL )  81 ( 3A ) A442 - A442  1994.09

Research paper, summary (international conference)  

平滑筋に対する吸入麻酔薬の直接作用機序

山蔭 道明, 土田 英昭, 並木 昭義

麻酔 ( 克誠堂出版 )  42 ( 11 ) p1578 - 1586  1993.11

CiNii

EFFECTS OF ACIDOSIS AND HYPOXIA ON THE CONTRACTILITY OF CANINE TRACHEAL SMOOTH-MUSCLE - ROLE OF INTRACELLULAR CA2+ AND PH

M YAMAKAGE, T KAWAMATA, S KOHRO, A NAMIKI

ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS )  79 ( 3A ) A1208 - A1208  1993.09

Research paper, summary (international conference)  

INHIBITORY EFFECTS OF HALOTHANE ON HIGH K+-INDUCED CANINE TRACHEAL SMOOTH-MUSCLE CONTRACTION AND INTRACELLULAR CA2+

M YAMAKAGE, T KAWAMATA, S KOHRO, A NAMIKI

ANESTHESIOLOGY ( LIPPINCOTT WILLIAMS & WILKINS )  79 ( 3A ) A1207 - A1207  1993.09

Research paper, summary (international conference)  

Prospective Study of Factors Leading to Fall in Body Temperature During Operation in Extensively Burned Patients.

YAMAKAGE Michiaki, YOSHIDA Izumi, KAWAMATA Tomoyuki, YAMAUCHI Masanori, NAMIKI Akiyoshi

J.J.S.C.A ( THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA )  13 ( 6 ) 548 - 554  1993

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We investigated factors leading to fall in body temperature during surgery in five extensively burned patients (burn index>30), prospectively. The difference in the temperatures at the beginning and the end of the operation was regarded as the "temperature gradient". There was no significant correlation between the temperature gradient and burn index, duration of anesthesia or operation, amount of blood loss or transfusion, or operating area. The temperature gradient of the GOI (nitrous oxide+oxygen+isoflurane) group (-1.48&plusmn;0.58(mean&plusmn;SD)&deg;C, n=10) was significantly lower than that of the GO+KM (GO+ketamine+midazolam) group (-0.80&plusmn;0.30&deg;C, n=16) (P<0.01). The temperature gradient of the group in prone position (-1.91&plusmn;0.31&deg;C, n=14) was significantly lower than that of the group in supine position (-0.08&plusmn;0.34&deg;, n=12) (P=0.001). For the intraoperative management of body temperature in exten-sively burned patients, we recommend Ketamine rather than inhalational anesthetics, and that the duration of skin sterilization, especially in patients in prone position, be shortened.

DOI CiNii

Mechanisms of action of volatile anesthetics on smooth muscle

M. Yamakage, H. Tsuchida, A. Namiki

Japanese Journal of Anesthesiology   42 ( 11 ) 1578 - 1586  1993

Book review, literature introduction, etc.  

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The development of intracellular Ca2+ fluorescent indicators and specific enzymatic substances as well as the application of the patch-clamp method have made it possible to clarify the mechanisms of action of volatile anesthetics on various smooth muscles. Volatile anesthetics inhibit smooth muscle contraction in part by decreasing intracellular Ca2+ concentration ([Ca2+]i) this effect is mediated by blocking calcium channels, especially the L-type voltage-operated channel, and by raising the intracellular cyclic AMP and cyclic GMP levels. Volatile anesthetic-induced suppression of smooth muscle contraction is also attributable to mechanisms independent of [Ca2+]i, which involve the depression of Ca2+ sensitization mediated by C kinase.

PubMed

三尖弁閉鎖不全を合併した拘束型心筋症の開心術麻酔経験

山内 正憲, 山蔭 道明, 土田 英昭

臨床麻酔 ( 真興交易(株)医書出版部 )  16 ( 7 ) 919 - 920  1992.07

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拘束型心筋症に重度のTR(三尖弁閉鎖不全)を合併した17歳男で,ミダゾラムとフェンタニールで導入し,ベクロニウムで筋弛緩を得た.肺動脈カテーテルと共にTEE(経食道内心エコー)を使用して心機能を評価し,カテコラミンの投与量などを決定した.TEEにより心房の大きさや,TRやMR(僧帽弁閉鎖不全)の程度も確認出来る為,三尖弁弁輪形成術を連続的に評価しながら補液管理を行う一方,MRの悪化に対し細心の注意を払う事が出来た