Papers - YOKOTA Shinichi

High prevalence of erythromycin resistance and macrolide-resistance genes, mefA and ermB, in Streptococcus pneumoniae isolates from the upper respiratory tracts of children in the Sapporo district, Japan

Atsushi Harimaya, Shin-Ichi Yokota, Kiyoshi Sato, Norikazu Yamazaki, Tetsuo Himi, Nobuhiro Fujii

Journal of Infection and Chemotherapy ( Springer Japan )  13 ( 4 ) 219 - 223  2007  [Refereed]

DOI PubMed

Colonization and turnover of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in otitis-prone children

Shin-ichi Yokota, Atsushi Harimaya, Kiyoshi Sato, Yukihiro Somekawa, Tetsuo Himi, Nobuhiro Fujii

MICROBIOLOGY AND IMMUNOLOGY   51 ( 2 ) 223 - 230  2007  [Refereed]

Single nucleotide polymorphisms and functional analysis of MxA promoter region in multiple sclerosis

Hiroyasu Furuyama, Susumu Chiba, Tamaki Okabayashi, Shin-ichi Yokota, Michio Nonaka, Tomihiro Imai, Nobuhiro Fujii, Hiroyuki Matsumoto

JOURNAL OF THE NEUROLOGICAL SCIENCES   249 ( 2 ) 153 - 157  2006.11  [Refereed]

DOI

Anti-HSP auto-antibodies enhance HSP-induced pro-inflammatory cytokine production in human monocytic cells via Toll-like receptors

S Yokota, S Minota, N Fujii

INTERNATIONAL IMMUNOLOGY ( OXFORD UNIV PRESS )  18 ( 4 ) 573 - 580  2006.04  [Refereed]

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Auto-antibodies against heat shock proteins (HSPs) are frequently found in the sera of patients with rheumatic and other autoimmune diseases. However, it is unclear whether these auto-antibodies play a role in the pathophysiology and etiology of these diseases. We found that a murine anti-HSP60 mAb enhanced the production of IL-8 and tumor necrosis factor-alpha induced by human HSP60 in the human monocytic cell lines THP-1 and U937, and human peripheral blood monocytes. Similar enhancement was observed with the combination of human HSP70 protein and a murine anti-HSP70 mAb. The enhancing effects were also observed for F(ab')(2) fragment, but not for monovalent Fab fragment. This suggests that the enhancement is due to cross-linking of HSP by the anti-HSP antibodies. The induction of IL-8 was dramatically suppressed by the transfection of a dominant-negative mutant of Toll-like receptor 4. We also found that sera from patients with rheumatic autoimmune diseases, which contained higher anti-HSP60 auto-antibody titers than sera from healthy donors, significantly enhanced the IL-8 production induced by human HSP60 in THP-1 cells. We propose that auto-antibodies against HSPs have the potential to play a pathogenic role in rheumatic autoimmune diseases by enhancing inflammatory reactions.

DOI

Cytokine regulation in SARS coronavirus infection compared to other respiratory virus infections

T Okabayashi, H Kariwa, S Yokota, S Iki, T Indoh, N Yokosawa, Takashima, I, H Tsutsumi, N Fujii

JOURNAL OF MEDICAL VIROLOGY   78 ( 4 ) 417 - 424  2006.04  [Refereed]

DOI

Autoantibodies against HSP70 family proteins were detected in the cerebrospinal fluid from patients with multiple sclerosis

S Chiba, S Yokota, K Yonekura, S Tanaka, H Furuyama, H Kubota, N Fujii, H Matsumoto

JOURNAL OF THE NEUROLOGICAL SCIENCES   241 ( 1-2 ) 39 - 43  2006.02  [Refereed]

DOI

Alterations of pbp1a, pbp2b, and pbp2x in Streptococcus pneumoniae isolates from children with otolaryngological infectious disease in the Sapporo district of Japan

Atsushi Harimaya, Shin-Ichi Yokota, Kiyoshi Sato, Jun-Ichi Koizumi, Norikazu Yamazaki, Tetsuo Himi, Nobuhiro Fujii

Journal of Infection and Chemotherapy ( Springer Japan )  12 ( 6 ) 366 - 371  2006  [Refereed]

DOI PubMed

Serum-dependent expression of promyelocytic leukemia protein suppresses propagation of influenza virus

S Iki, S Yokota, T Okabayashi, N Yokosawa, K Nagata, N Fujii

VIROLOGY   343 ( 1 ) 106 - 115  2005.12  [Refereed]

DOI PubMed CiNii

Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication

S Yokota, N Yokosawa, T Okabayashi, T Suzutani, N Fujii

VIROLOGY   338 ( 1 ) 173 - 181  2005.07  [Refereed]

DOI PubMed CiNii

Five-year follow-up study of mother-to-child transmission of Helicobacter pylori infection detected by a random amplified polymorphic DNA fingerprinting method

M Konno, N Fujii, S Yokota, K Sato, M Takahashi, K Sato, E Mino, T Sugiyama

JOURNAL OF CLINICAL MICROBIOLOGY   43 ( 5 ) 2246 - 2250  2005.05  [Refereed]

DOI

Mumps virus V protein antagonizes degradation interferon without the complete of STAT1

T Kubota, N Yokosawa, S Yokota, N Fujii, M Tashiro, A Kato

JOURNAL OF VIROLOGY   79 ( 7 ) 4451 - 4459  2005.04  [Refereed]

DOI PubMed

An antibody to VacA of Helicobacter pylori in the CSF of patients with Miller-Fisher syndrome

S Chiba, T Sugiyama, K Yonekura, S Tanaka, H Matsumoto, N Fujii, S Yokota, T Hirayama

NEUROLOGY   63 ( 11 ) 2184 - 2186  2004.12  [Refereed]

Prevalence of anti-heat shock protein antibodies in cerebrospinal fluids of patients with Guillain-Barre syndrome

K Yonekura, S Yokota, S Tanaka, H Kubota, N Fujii, H Matsumoto, S Chiba

JOURNAL OF NEUROIMMUNOLOGY   156 ( 1-2 ) 204 - 209  2004.11  [Refereed]

DOI

Membrane-anchored CD14 is important for induction of interleukin-8 by lipopolysaccharide and peptidoglycan in uroepithelial cells

T Shimizu, S Yokota, S Takahashi, Y Kunishima, K Takeyama, N Masumori, A Takahashi, M Matsukawa, N Itoh, T Tsukamoto, N Fujii

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY   11 ( 5 ) 969 - 976  2004.09  [Refereed]

DOI

Pulmonary collectins enhance phagocytosis of mycobacterium avium through increased activity of mannose receptor

K Kudo, H Sano, H Takahashi, K Kuronuma, SI Yokota, N Fujii, KI Shimada, Yano, I, Y Kumazawa, DR Voelker, S Abe, Y Kuroki

JOURNAL OF IMMUNOLOGY   172 ( 12 ) 7592 - 7602  2004.06  [Refereed]

Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway

S Yokota, N Yokosawa, T Okabayashi, T Suzutani, S Miura, K Jimbow, N Fujii

JOURNAL OF VIROLOGY   78 ( 12 ) 6282 - 6286  2004.06  [Refereed]

DOI PubMed CiNii

Pulmonary surfactant protein A augments the phagocytosis of streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A

K Kuronuma, H Sano, K Kato, K Kudo, N Hyakushima, S Yokota, H Takahashi, N Fujii, H Suzuki, T Kodama, S Abe, Y Kuroki

JOURNAL OF BIOLOGICAL CHEMISTRY   279 ( 20 ) 21421 - 21430  2004.05  [Refereed]

DOI PubMed CiNii

Growth arrest of epithelial cells during measles virus infection is caused by upregulation of interferon regulatory factor 1

S Yokota, T Okabayashi, N Yokosawa, N Fujii

JOURNAL OF VIROLOGY ( AMER SOC MICROBIOLOGY )  78 ( 9 ) 4591 - 4598  2004.05  [Refereed]

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Natural infection with measles virus (MeV) is initiated when the virus reaches epithelial cells in the respiratory tract, oropharynx, or conjunctivae. Human epithelial cells infected with MeV frequently show growth suppression. In this study, we investigated the possible mechanisms for this suppression. The bronchiolar epithelial cell A549 showed growth arrest in G(0)/G(1) following MeV infection or treatment with gamma interferon (IFN-gamma). IFN regulatory factor-1 (IRF-1) was upregulated during MeV infection, although A549 did not produce IFN-gamma. Cells of the cervical squamous cell line SiHa persistently infected with various strains of MeV displayed slower growth than uninfected SiHa cells, although the growth rates varied depending on the MeV strain. Transfection of antisense-oriented IRF-1 cDNA released the MeV-infected SiHa cells from growth suppression. Although these infected cells did not produce IFN-gamma and suppressed IFN-alpha/beta-induced Jak1 phosphorylation, Jak1 was constitutively phosphorylated. The growth rates negatively correlated with levels of both IRF-1 expression and constitutively phosphoryllated Jak1. These results indicate that MeV upregullates IRF-1 in a manner that is independent of IFN but dependent on the JAK/STAT pathway. This induction of IRF-1 appears to suppress cell growth, although the extent seems to vary among MeV strains.

DOI PubMed CiNii

Macrolide-resistant Streptococcus pneumoniae clinical isolates that occur in Hokkaido prefecture, Japan

Shin-Ichi Yokota, Kiyoshi Sato, Shigeru Yoshida, Tasuku Hayashi, Keiko Matsuda, Osamu Kuwahara, Satoshi Habadera, Kazuhiko Kobayashi, Ryo Ueno, Hirotsugu Akizawa, Nobuhiro Fujii

Journal of Infection and Chemotherapy ( Springer Japan )  10 ( 5 ) 284 - 287  2004  [Refereed]

DOI PubMed CiNii

The throat flora and its mitogenic activity in patients with Kawasaki disease

N Horita, S Yokota, S Fuse, M Takamuro, H Tomita, K Sato, N Fujii, H Tsutsumi

MICROBIOLOGY AND IMMUNOLOGY   48 ( 11 ) 899 - 903  2004  [Refereed]